Product Name: C1ORF74 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated Catalog No. : TAP01-90208R-A350 Intended Use: For Research Use Only. Not for used in diagnostic procedures.

Size 100ul Concentration 1ug/ul ID 148304 ISO Type Rabbit IgG Clone N/A Immunogen Range Conjugation ALEXA FLUOR® 350 Subcellular Locations

Applications IF(IHC-P) Cross Reactive Species Human, Mouse, Rat Source KLH conjugated synthetic peptide derived from human C1ORF74 Applications with IF(IHC-P)(1:50-200) Dilutions Purification Purified by A. Background 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the . There are about 3,000 on , and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to . Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanomaand multiple myeloma. The C1orf74 gene product has been provisionally designated C1orf74 pending further characterization.

Synonyms chromosome1 open reading frame74; C1orf74; CA074_HUMAN; Chromosome 1 open reading frame 74; FLJ25078; Hypothetical protein LOC148304; UPF0739 protein C1orf74. Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

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