Table S2: Detailed information pertaining to pathways on which the identified to be somatically mutated in UM lie.

Sl. name Pathway Identified from KEGG Database Pathway Identified from Reactome No. Database Entry Name Species UniProt Species Pathway names ID 1 CDK11B - - - P21127 Homo "Cell Cycle; sapiens Developmental Biology; Mitotic G2- G2/M phases; Transcriptional Regulation of White Adipocyte Differentiation" 2 CLSTN1 ------3 ANGPTL7 ------4 DNALI1 hsa05016 Huntington's disease Homo - - - sapiens (human) 5 AMPD1 hsa00230 Purine metabolism Homo P23109 Homo Metabolism of sapiens sapiens nucleotides. hsa01100 Metabolic pathways Homo sapiens 6 SF3B1 hsa03040 Spliceosome Homo O75533 Homo ; sapiens sapiens Processing of Capped Intron-Containing Pre- mRNA. 7 SPATA3 ------8 DHX30 ------9 C1QTNF2 ------10 PCLO ------11 TNFRSF10C hsa04060 Cytokine-cytokine Homo - - - receptor interaction sapiens hsa04210 Homo sapiens hsa04650 Natural killer cell Homo mediated cytotoxicity sapiens hsa05162 Measles Homo sapiens hsa05164 Influenza A Homo sapiens

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Sl. Gene Pathway Identified from KEGG Database Pathway Identified from Reactome No. name Database Entry Name Species UniProt Species Pathway names ID 12 GNAQ hsa04726 Serotonergic synapse Homo P21279 Mus Multiple pathways hsa04730 Long-term depression sapiens musculus hsa04020 Calcium signaling pathway hsa04270 Vascular smooth muscle contraction hsa04540 Gap junction hsa04713 Circadian entrainment hsa04720 Long-term potentiation hsa04723 Retrograde endocannabinoid signaling hsa04724 Glutamatergic synapse hsa04725 Cholinergic synapse hsa04728 Dopaminergic synapse hsa04912 GnRH signaling pathway hsa04916 Melanogenesis hsa04961 Endocrine and other factor-regulated calcium reabsorption hsa04970 Salivary secretion hsa04971 Gastric acid secretion hsa04972 Pancreatic secretion hsa05010 Alzheimer's disease hsa05016 Huntington's disease hsa05142 Chagas disease (American trypanosomiasis) hsa05143 African trypanosomiasis hsa05146 Amoebiasis 13 MUC2 hsa05146 Amoebiasis Homo Q02817 Homo Metabolism of sapiens sapiens ; O-linked glycosylation of mucins; Post- hsa05110 Vibrio cholerae infection translational modification

14 CLEC16A ------15 AMFR hsa04141 Protein processing in Homo - - - endoplasmic reticulum sapiens 16 KIAA0513 ------17 C17orf97 ------18 KRTAP4------5 19 LEPREL4 ------20 FBN3 - - - Q75N90 Homo Elastic fibre sapiens formation; Extracellular matrix organization

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Sl. Gene Pathway Identified from KEGG Database Pathway Identified from Reactome No. name Database Entry Name Species UniProt Species Pathway names ID 21 CIC hsa04260 Cardiac muscle Homo - - - contraction sapiens hsa04976 Bile secretion hsa01040 Biosynthesis of unsaturated fatty acids hsa04725 Cholinergic synapse hsa04966 Collecting duct acid secretion 22 NEFH hsa05014 Amyotrophic lateral Homo - - - sclerosis (ALS) sapiens 23 SOX10 ------24 MAGEH1 ------25 ZFY hsa04144 Endocytosis Homo - - - hsa04350 TGF-beta signaling sapiens pathway