November 3, 2020 u vol. 117 u no. 44

From the Cover

27141 Using nanodecoys to treat COVID-19 27245 Coexisting magnetism in quantum crystal 27516 Gut microbiome and multiple sclerosis 27549 Famine and tuberculosis risk 27731 Neural responses to political information

Contents

THIS WEEK IN PNAS—This week’s research highlights Cover image: Pictured are decoy 27063 In This Issue nanoparticles designed to combat COVID-19. Using a murine model, Lang Rao et al. demonstrated that biomimetic INNER WORKINGS—An over-the-shoulder look at scientists at work nanodecoys protect host cells from COVID-19 by neutralizing SARS-CoV-2 27066 Crop researchers harness artificial intelligence to breed crops for the and inflammatory cytokines, while also changing climate suppressing lung injury tied to acute Carolyn Beans . The results suggest that antiviral nanotechnology may enhance future therapies for COVID-19 and other COMMENTARIES infectious diseases. See the article by 27070 Another step toward demystifying deep neural networks – Rao et al. on pages 27141 27147. Michael Elad, Dror Simon, and Aviad Aberdam Image credit: Lang Rao. See companion article on page 24652 in issue 40 of volume 117 27073 The human quest for discovering mathematical beauty in the arts Stefano Balietti See companion article on page 26580 in issue 43 of volume 117

LETTERS 27076 Protective effect of mandatory face masks in the public—relevant variables with likely impact on outcome were not considered Gu¨nter Kampf 27078 Do face masks help? is not the question Qin Xiang Ng, Michelle Lee Zhi Qing De Deyn, and Wee Song Yeo

27080 The Kinsey scale is ill-suited to most sexuality research because it does not measure a single construct Brendan P. Zietsch and Morgan J. Sidari 27081 Reply to Zietsch and Sidari: Male sexual arousal patterns (and sexual orientation) are partly unidimensional J. Michael Bailey and J. Jabbour 27082 β-Arrestin2 is increased in liver fibrosis in humans and rodents Robert Schierwagen, Peter Dietrich, Sabine Klein, Frank Erhard Uschner, Cristina Ortiz, Olaf Tyc, Sandra Torres, Claus Hellerbrand, Tilman Sauerbruch, and Jonel Trebicka 27085 Reply to Schierwagen et al.: β-Arrestins in liver disease Songling Liu, Louis M. Luttrell, Richard T. Premont, and Don C. Rockey

Free online through the PNAS open access option. PNAS u November 3, 2020 u vol. 117 u no. 44 u iii–vii Downloaded by guest on September 28, 2021 27346 Unexpected specificity within dynamic transcriptional BRIEF REPORT protein–protein complexes 27087 Mobile device data reveal the dynamics in a positive Matthew J. Henley, Brian M. Linhares, Brittany S. Morgan, relationship between human mobility and Tomasz Cierpicki, Carol A. Fierke, and Anna K. Mapp COVID-19 infections Chenfeng Xiong, Songhua Hu, Mofeng Yang, Weiyu Luo, COMPUTER SCIENCES and Lei Zhang 27162 Overparameterized neural networks implement associative memory PHYSICAL SCIENCES Adityanarayanan Radhakrishnan, Mikhail Belkin, and Caroline Uhler APPLIED PHYSICAL SCIENCES 27090 Prediction and prevention of disproportionally dominant agents in complex networks EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Sandro Claudio Lera, Alex Pentland, and Didier Sornette 27171 Annually resolved Atlantic sea surface temperature 27096 Behavior and mechanics of dense microgel suspensions variability over the past 2,900 y Svetoslav V. Nikolov, Alberto Fernandez-Nieves, Francois Lapointe, Raymond S. Bradley, Pierre Francus, and Alexander Alexeev Nicholas L. Balascio, Mark B. Abbott, Joseph S. Stoner, Guillaume St-Onge, Arnaud De Coninck, 27104 Optical signatures of multifold fermions in the chiral and Thibault Labarre topological semimetal CoSi ´ 27179 Chaos in a simple model of a delta network Bing Xu, Zhenyao Fang, Miguel-Angel Sa´nchez-Martı´nez, Gerard Salter, Vaughan R. Voller, and Chris Paola Jorn W. F. Venderbos, Zhuoliang Ni, Tian Qiu, Kaustuv Manna, Kefeng Wang, Johnpierre Paglione, Christian Bernhard, Claudia Felser, Eugene J. Mele, Adolfo G. ENGINEERING Grushin, Andrew M. Rappe, and Liang Wu 27188 Superhydrophobic surfaces for extreme 27111 Entropy-controlled cross-linking in environmental conditions linker-mediated vitrimers Henry Lambley, Thomas M. Schutzius, and Dimos Poulikakos Qun-Li Lei, Xiuyang Xia, Juan Yang, Massimo Pica Ciamarra, and Ran Ni 27195 Design principles for self-forming interfaces enabling stable lithium-metal anodes BIOPHYSICS AND COMPUTATIONAL BIOLOGY Yingying Zhu, Vikram Pande, Linsen Li, Bohua Wen, 27116 Broad distributions of transition-path times are Menghsuan Sam Pan, David Wang, Zi-Feng Ma, Venkatasubramanian Viswanathan, fingerprints of multidimensionality of the and Yet-Ming Chiang underlying free energy landscapes Rohit Satija, Alexander M. Berezhkovskii, 27204 A 3D-printed molecular ferroelectric metamaterial and Dmitrii E. Makarov Yong Hu, Zipeng Guo, Andrew Ragonese, Taishan Zhu, Saurabh Khuje, Changning Li, Jeffrey C. Grossman, Chi Zhou, 27124 Phase separation at the nanoscale quantified Mostafa Nouh, and Shenqiang Ren by dcFCCS Sijia Peng, Weiping Li, Yirong Yao, Wenjing Xing, Pilong Li, and Chunlai Chen ENVIRONMENTAL SCIENCES ’ 27132 Desmosome architecture derived from molecular 27211 Changing nutrient cycling in Lake Baikal, the world s dynamics simulations and cryo-electron tomography oldest lake Mateusz Sikora, Utz H. Ermel, Anna Seybold, Michael Kunz, George E. A. Swann, Virginia N. Panizzo, Sebastiano Giulia Calloni, Julian Reitz, R. Martin Vabulas, Gerhard Piccolroaz, Vanessa Pashley, Matthew S. A. Horstwood, Hummer, and Achilleas S. Frangakis Sarah Roberts, Elena Vologina, Natalia Piotrowska, Michael Sturm, Andre Zhdanov, Nikolay Granin, CHEMISTRY Charlotte Norman, Suzanne McGowan, and Anson W. Mackay 27141 Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines PHYSICS Lang Rao, Shuai Xia, Wei Xu, Rui Tian, Guocan Yu, Chenjian Gu, 27218 Funneled energy landscape unifies principles of Pan Pan, Qian-Fang Meng, Xia Cai, Di Qu, Lu Lu, Youhua Xie, protein binding and evolution Shibo Jiang, and Xiaoyuan Chen Zhiqiang Yan and Jin Wang 27148 Plasmonic probing of the adhesion strength of single 27224 Magnetized topological insulator multilayers microbial cells Chao Lei, Shu Chen, and Allan H. MacDonald Yi-Nan Liu, Zhen-Ting Lv, Wen-Li Lv, and Xian-Wei Liu 27231 Tuning the quantumness of simple Bose systems: A 27154 Strong sequentially bridged MXene sheets universal phase diagram Sijie Wan, Xiang Li, Yanlei Wang, Ying Chen, Xi Xie, Rui Yang, Youssef Kora, Massimo Boninsegni, Dam Thanh Son, Antoni P. Tomsia, Lei Jiang, and Qunfeng Cheng and Shiwei Zhang 27329 Mapping glycan-mediated galectin-3 interactions by 27238 Extremely small twist elastic constants in lyotropic live cell proximity labeling nematic liquid crystals Eugene Joeh, Timothy O’Leary, Weichao Li, Richard Hawkins, Clarissa F. Dietrich, Peter J. Collings, Thomas Sottmann, Per Jonathan R. Hung, Christopher G. Parker, and Mia L. Huang Rudquist, and Frank Giesselmann

27339 Experimentally determined strengths of favorable 27245 Multiphase magnetism in Yb2Ti2O7 and unfavorable interactions of amide atoms Allen Scheie, Jonas Kindervater, Shu Zhang, Hitesh J. involved in protein self-assembly in water Changlani, Gabriele Sala, Georg Ehlers, Andre Xian Cheng, Irina A. Shkel, Kevin O’Connor, Heinemann, Gregory S. Tucker, Seyed M. Koohpayeh, and M. Thomas Record Jr and Collin Broholm

iv u www.pnas.org Contents Downloaded by guest on September 28, 2021 BIOCHEMISTRY SOCIAL SCIENCES 27329 Mapping glycan-mediated galectin-3 interactions by ECONOMIC SCIENCES live cell proximity labeling 27255 Life cycle patterns of cognitive performance over the Eugene Joeh, Timothy O’Leary, Weichao Li, Richard Hawkins, long run Jonathan R. Hung, Christopher G. Parker, and Mia L. Huang Anthony Strittmatter, Uwe Sunde, and Dainis Zegners 27339 Experimentally determined strengths of favorable and unfavorable interactions of amide atoms ENVIRONMENTAL SCIENCES involved in protein self-assembly in water Xian Cheng, Irina A. Shkel, Kevin O’Connor, 27549 Prenatal and early-life exposure to the Great Chinese and M. Thomas Record Jr Famine increased the risk of tuberculosis in 27346 Unexpected specificity within dynamic transcriptional adulthood across two generations – Qu Cheng, Robert Trangucci, Kristin N. Nelson, Wenjiang Fu, protein protein complexes Philip A. Collender, Jennifer R. Head, Christopher M. Hoover, Matthew J. Henley, Brian M. Linhares, Brittany S. Morgan, Nicholas K. Skaff, Ting Li, Xintong Li, Yue You, Liqun Fang, Tomasz Cierpicki, Carol A. Fierke, and Anna K. Mapp Song Liang, Changhong Yang, Jin’ge He, Jonathan L. Zelner, 27354 Histone H3.3 G34 mutations promote aberrant PRC2 and Justin V. Remais activity and drive tumor progression Siddhant U. Jain, Sima Khazaei, Dylan M. Marchione, POLITICAL SCIENCES Stefan M. Lundgren, Xiaoshi Wang, Daniel N. Weinberg, Shriya Deshmukh, Nikoleta Juretic, Chao Lu, C. 27262 Sanctuary policies reduce deportations without David Allis, Benjamin A. Garcia, Nada Jabado, increasing crime and Peter W. Lewis David K. Hausman 27365 DOT1L-controlled cell-fate determination and transcription elongation are independent of PSYCHOLOGICAL AND COGNITIVE SCIENCES H3K79 methylation 27268 Formation of global self-beliefs in the human brain Kaixiang Cao, Michal Ugarenko, Patrick A. Ozark, Juan Marion Rouault and Stephen M. Fleming Wang, Stacy A. Marshall, Emily J. Rendleman, Kaiwei Liang, Lu Wang, Lihua Zou, Edwin R. Smith, Feng Yue, and Ali Shilatifard SOCIAL SCIENCES 27277 Economic hardship and mental health complaints during COVID-19 BIOPHYSICS AND COMPUTATIONAL BIOLOGY Dirk Witteveen and Eva Velthorst 27116 Broad distributions of transition-path times are 27285 Gender differences in COVID-19 attitudes and fingerprints of multidimensionality of the behavior: Panel evidence from eight countries underlying free energy landscapes Vincenzo Galasso, Vincent Pons, Paola Profeta, Michael Rohit Satija, Alexander M. Berezhkovskii, Becher, Sylvain Brouard, and Martial Foucault and Dmitrii E. Makarov 27124 Phase separation at the nanoscale quantified SUSTAINABILITY SCIENCE by dcFCCS Sijia Peng, Weiping Li, Yirong Yao, Wenjing Xing, Pilong Li, 27292 Voluntary leadership and the emergence of and Chunlai Chen institutions for self-governance Krister P. Andersson, Kimberlee Chang, 27218 Funneled energy landscape unifies principles of and Adriana Molina-Garzo´n protein binding and evolution Zhiqiang Yan and Jin Wang 27374 Three-dimensional deconvolution processing for BIOLOGICAL SCIENCES STEM cryotomography Barnali Waugh, Sharon G. Wolf, Deborah Fass, Eric Branlund, APPLIED BIOLOGICAL SCIENCES Zvi Kam, John W. Sedat, and Michael Elbaum 27300 Liquid drop of DNA libraries reveals total genome information 27381 Identify potent SARS-CoV-2 main protease inhibitors Stanislav S. Terekhov, Igor E. Eliseev, Leyla A. Ovchinnikova, via accelerated free energy perturbation-based Marsel R. Kabilov, Andrey D. Prjibelski, Alexey E. Tupikin, virtual screening of existing drugs Ivan V. Smirnov, Alexey A. Belogurov Jr, Konstantin V. Zhe Li, Xin Li, Yi-You Huang, Yaoxing Wu, Runduo Liu, Lingli Severinov, Yakov A. Lomakin, Sidney Altman, Zhou, Yuxi Lin, Deyan Wu, Lei Zhang, Hao Liu, Ximing Xu, and Alexander G. Gabibov Kunqian Yu, Yuxia Zhang, Jun Cui, Chang-Guo Zhan, Xin Wang, and Hai-Bin Luo 27307 In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region CELL BIOLOGY Kalliopi Skamaki, Stephane Emond, Matthieu Chodorge, 27388 Computationally enhanced quantitative phase John Andrews, D. Gareth Rees, Daniel Cannon, Bojana Popovic, Andrew Buchanan, Ralph R. Minter, microscopy reveals autonomous oscillations and Florian Hollfelder in mammalian cell growth Xili Liu, Seungeun Oh, Leonid Peshkin, and Marc W. Kirschner 27319 PLA2G6 guards placental trophoblasts against ferroptotic injury 27400 Macropinocytosis-mediated membrane recycling Ofer Beharier, Vladimir A. Tyurin, Julie P. Goff, Jennifer drives neural crest migration by delivering Guerrero-Santoro, Kazuhiro Kajiwara, Tianjiao Chu, F-actin to the lamellipodium Yulia Y. Tyurina, Claudette M. St Croix, Callen T. Yuwei Li, Walter G. Gonzalez, Andrey Andreev, Weiyi Tang, Wallace, Samuel Parry, W. Tony Parks, Valerian E. Shashank Gandhi, Alexandre Cunha, David Prober, Carlos Lois, Kagan, and Yoel Sadovsky and Marianne E. Bronner

Contents PNAS u November 3, 2020 u vol. 117 u no. 44 u v Downloaded by guest on September 28, 2021 27412 Blocking PPARγ interaction facilitates Nur77 interdiction 27516 Interactions between host genetics and gut of fatty acid uptake and suppresses breast microbiota determine susceptibility to cancer progression CNS autoimmunity Peng-bo Yang, Pei-pei Hou, Fu-yuan Liu, Wen-bin Hong, Theresa L. Montgomery, Axel Ku¨nstner, Josephine J. Hang-zi Chen, Xiao-yu Sun, Peng Li, Yi Zhang, Cui-yu Ju, Li-juan Kennedy, Qian Fang, Lori Asarian, Rachel Culp-Hill, Angelo Luo, Sheng-fu Wu, Jia-xin Zhou, Zhi-jing Wang, Jian-ping He, Li D’Alessandro, Cory Teuscher, Hauke Busch, Li, Tong-Jin Zhao, Xianming Deng, Tianwei Lin, and Qiao Wu and Dimitry N. Krementsov 27423 Collective cancer cell invasion requires RNA 27528 Selective tumor antigen vaccine delivery to human + accumulation at the invasive front CD169 antigen-presenting cells using George Chrisafis, Tianhong Wang, Konstadinos Moissoglu, ganglioside-liposomes Alexander N. Gasparski, Yeap Ng, Roberto Weigert, Alsya J. Affandi, Joanna Grabowska, Katarzyna Olesek, Miguel Stephen J. Lockett, and Stavroula Mili Lopez Venegas, Arnaud Barbaria, Ernesto Rodrı´guez, Patrick P. G. Mulder, Helen J. Pijffers, Martino Ambrosini, Hakan Kalay, Tom O’Toole, Eline S. Zwart, Geert Kazemier, DEVELOPMENTAL BIOLOGY Kamran Nazmi, Floris J. Bikker, Johannes Sto¨ckl, Alfons J. M. 27435 B3GALT5 knockout alters gycosphingolipid profile van den Eertwegh, Tanja D. de Gruijl, Gert Storm, Yvette van and facilitates transition to human naïve pluripotency Kooyk, and Joke M. M. den Haan Ruey-Jen Lin, Ming-Wei Kuo, Bei-Chia Yang, Hsiu-Hui Tsai, 27540 IL-36R signaling integrates innate and adaptive Kowa Chen, Jing-Rong Huang, Yun-Shien Lee, Alice L. Yu, immune-mediated protection against and John Yu enteropathogenic bacteria Vu L. Ngo, Hirohito Abo, Michal Kuczma, Edyta Szurek, Nora ECOLOGY Moore, Oscar Medina-Contreras, Asma Nusrat, Didier Merlin, 27445 Diatom modulation of select bacteria through use of Andrew T. Gewirtz, Leszek Ignatowicz, and Timothy L. Denning two unique secondary metabolites Ahmed A. Shibl, Ashley Isaac, Michael A. Ochsenkuhn,̈ Anny MEDICAL SCIENCES Ca´rdenas, Cong Fei, Gregory Behringer, Marc Arnoux, Nizar 27141 Decoy nanoparticles protect against COVID-19 by Drou, Miraflor P. Santos, Kristin C. Gunsalus, Christian R. concurrently adsorbing viruses and Voolstra, and Shady A. Amin inflammatory cytokines 27456 Seasonality and uncertainty in global COVID-19 Lang Rao, Shuai Xia, Wei Xu, Rui Tian, Guocan Yu, Chenjian Gu, growth rates Pan Pan, Qian-Fang Meng, Xia Cai, Di Qu, Lu Lu, Youhua Xie, Cory Merow and Mark C. Urban Shibo Jiang, and Xiaoyuan Chen 27549 Prenatal and early-life exposure to the Great Chinese EVOLUTION Famine increased the risk of tuberculosis in 27465 Revealing mechanisms of mating plug function under adulthood across two generations sexual selection Qu Cheng, Robert Trangucci, Kristin N. Nelson, Wenjiang Fu, Paula Stockley, Catarina Franco, Amy J. Claydon, Amanda Philip A. Collender, Jennifer R. Head, Christopher M. Hoover, Davidson, Dean E. Hammond, Philip J. Brownridge, Jane L. Nicholas K. Skaff, Ting Li, Xintong Li, Yue You, Liqun Fang, Hurst, and Robert J. Beynon Song Liang, Changhong Yang, Jin’ge He, Jonathan L. Zelner, and Justin V. Remais 27474 A release from developmental bias accelerates 27556 MNK2 governs the macrophage morphological diversification in butterfly eyespots antiinflammatory phenotype Oskar Brattstro¨m, Kwaku Aduse-Poku, Erik van Bergen, Vernon French, and Paul M. Brakefield Margarita Bartish, Dongmei Tong, Yangxun Pan, Majken Wallerius, Hui Liu, Johannes Ristau, Sabrina de Souza Ferreira, 27481 Toxin-like neuropeptides in the sea anemone Tatjana Wallmann, Vincent van Hoef, Laia Masvidal, Thomas Nematostella unravel recruitment from the Kerzel, Anne-Laure Joly, Christophe Goncalves, Samuel E. J. nervous system to venom Preston, Talin Ebrahimian, Christina Seitz, Jonas Bergh, Kristian Maria Y. Sachkova, Morani Landau, Joachim M. Surm, Jason Pietras, Stephanie Lehoux, Luigi Naldini, John Andersson, Macrander, Shir A. Singer, Adam M. Reitzel, and Yehu Moran Mario Leonardo Squadrito, Sonia V. del Rinco´n, Ola Larsson, and Charlotte Rolny δ GENETICS 27566 Polymerase promotes chromosomal rearrangements and imprecise double- 27493 Nucleosome Positioning Regulates the Establishment, strand break repair Stability, and Inheritance of Heterochromatin in Saccharomyces cerevisiae Jacob V. Layer, Lydie Debaize, Alexandria Van Scoyk, Nealia C. House, Alexander J. Brown, Yunpeng Liu, Kristen E. Stevenson, Daniel S. Saxton and Jasper Rine Michael Hemann, Steven A. Roberts, Brendan D. Price, David M. Weinstock, and Tovah A. Day IMMUNOLOGY AND INFLAMMATION 27502 Extracellular cyclic dinucleotides induce polarized MICROBIOLOGY responses in barrier epithelial cells by 27578 The cytokine MIF controls daily rhythms of symbiont adenosine signaling nutrition in an animal–bacterial association Denis Chang, Aaron T. Whiteley, Katlynn Bugda Gwilt, Eric J. Koch, Clotilde Bongrand, Brittany D. Bennett, Susannah Wayne I. Lencer, John J. Mekalanos, and Jay R. Thiagarajah Lawhorn, Silvia Moriano-Gutierrez, Marko Pende, Karim 27509 Bifidobacterium alters the gut microbiota and modulates Vadiwala, Hans-Ulrich Dodt, Florian Raible, William Goldman, the functional metabolism of T regulatory cells in the Edward G. Ruby, and Margaret McFall-Ngai context of immune checkpoint blockade 27587 Global diversity of microbial communities in Shan Sun, Lingjie Luo, Wenhua Liang, Qian Yin, Jing Guo, marine sediment Anthony M. Rush, Zhibao Lv, Qiming Liang, Michael A. Tatsuhiko Hoshino, Hideyuki Doi, Go-Ichiro Uramoto, Lars Fischbach, Justin L. Sonnenburg, Dylan Dodd, Mark M. Davis, Wo¨rmer, Rishi R. Adhikari, Nan Xiao, Yuki Morono, Steven and Feng Wang D’Hondt, Kai-Uwe Hinrichs, and Fumio Inagaki

vi u www.pnas.org Contents Downloaded by guest on September 28, 2021 27598 Stimulator of interferon genes (STING) is an essential 27694 The UBC27–AIRP3 ubiquitination complex proviral host factor for human rhinovirus species modulates ABA signaling by promoting A and C the degradation of ABI1 in Arabidopsis Kevin L. McKnight, Karen V. Swanson, Kathryn Austgen, Cindy Wenbo Pan, Baoying Lin, Xiaoyuan Yang, Lijing Liu, Ran Xia, Richards, Jonathan K. Mitchell, David R. McGivern, Ethan Jigang Li, Yaorong Wu, and Qi Xie Fritch, John Johnson, Katja Remlinger, Michal Magid-Slav, Maryna Kapustina, Shihyun You, and Stanley M. Lemon POPULATION BIOLOGY 27608 Synthetic gene-regulatory networks in the opportunistic human pathogen 27703 Acceleration of plague outbreaks in the Streptococcus pneumoniae second pandemic Robin A. Sorg, Clement Gallay, Laurye Van Maele, David J. D. Earn, Junling Ma, Hendrik Poinar, Jonathan Jean-Claude Sirard, and Jan-Willem Veening Dushoff, and Benjamin M. Bolker 27620 Defining principles that influence antimicrobial peptide activity against capsulated PSYCHOLOGICAL AND COGNITIVE SCIENCES Klebsiella pneumoniae 27277 Economic hardship and mental health complaints Renee M. Fleeman, Luis A. Macias, Jennifer S. Brodbelt, during COVID-19 and Bryan W. Davies Dirk Witteveen and Eva Velthorst 27627 Mosquito metabolomics reveal that dengue virus 27712 Neurotypical individuals fail to understand action replication requires phospholipid reconfiguration vitality form in children with autism via the remodeling cycle spectrum disorder Thomas Vial, Wei-Lian Tan, Eric Deharo, Dorothe´e Misse´, Luca Casartelli, Alessandra Federici, Lucia Fumagalli, Guillaume Marti, and Julien Pompon Ambra Cesareo, Monica Nicoli, Luca Ronconi, Andrea 27637 Structural basis of Chikungunya virus inhibition by Vitale, Massimo Molteni, Giacomo Rizzolatti, monoclonal antibodies and Corrado Sinigaglia Qun Fei Zhou, Julie M. Fox, James T. Earnest, Thiam-Seng 27719 Model-free decision making is prioritized when Ng, Arthur S. Kim, Guntur Fibriansah, Victor A. Kostyuchenko, learning to avoid harming others Jian Shi, Bo Shu, Michael S. Diamond, and Shee-Mei Lok Patricia L. Lockwood, Miriam C. Klein-Flu¨gge, Ayat Abdurahman, and Molly J. Crockett NEUROSCIENCE 27731 Conservative and liberal attitudes drive polarized 27268 Formation of global self-beliefs in the human brain neural responses to political content Marion Rouault and Stephen M. Fleming Yuan Chang Leong, Janice Chen, Robb Willer, and Jamil Zaki 27646 Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, CORRECTIONS Penelope J. Hallett, and Ole Isacson 27655 Forelimb force direction and magnitude PHYSICS independently controlled by spinal 27740 Novel electronic nematicity in heavily hole-doped modules in the macaque iron pnictide superconductors Amit Yaron, David Kowalski, Hiroaki Yaguchi, Kousuke Ishida, Masaya Tsujii, Suguru Hosoi, Yuta Mizukami, Tomohiko Takei, and Kazuhiko Seki Shigeyuki Ishida, Akira Iyo, Hiroshi Eisaki, Thomas Wolf, Kai Grube, Hilbert v. Lo¨hneysen, Rafael M. Fernandes, 27667 P7C3-A20 treatment one year after TBI in mice and Takasada Shibauchi repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition APPLIED BIOLOGICAL SCIENCES Edwin Va´zquez-Rosa, Min-Kyoo Shin, Matasha Dhar, Kalyani Chaubey, Coral J. Cintro´n-Pe´rez, Xinmiao Tang, Xudong Liao, 27741 BCG vaccine protection from severe Emiko Miller, Yeojung Koh, Sarah Barker, Kathryn Franke, disease 2019 (COVID-19) Danyel R. Crosby, Rachel Schroeder, Josie Emery, Terry C. Luis E. Escobar, Alvaro Molina-Cruz, Yin, Hisashi Fujioka, James D. Reynolds, Matthew M. Harper, and Carolina Barillas-Mury Mukesh K. Jain, and Andrew A. Pieper BIOPHYSICS AND COMPUTATIONAL BIOLOGY PHYSIOLOGY 27743 High-affinity oligoclonal TCRs define effective 27676 Liquid-liquid phase separation promotes animal adoptive T cell therapy targeting desiccation tolerance mutant KRAS-G12D Clinton Belott, Brett Janis, and Michael A. Menze Malcolm J. W. Sim, Jinghua Lu, Matthew Spencer, Francis Hopkins, Eric Tran, Steven A. Rosenberg, Eric O. Long, PLANT BIOLOGY and Peter D. Sun 27685 N-glycosylation shields Phytophthora sojae apoplastic effector PsXEG1 from a specific host aspartic protease MEDICAL SCIENCES Yeqiang Xia, Zhenchuan Ma, Min Qiu, Baodian Guo, Qi Zhang, 27745 PIWIL1 promotes gastric cancer via a Haibin Jiang, Baiyu Zhang, Yachun Lin, Mingrun Xuan, Liang piRNA-independent mechanism Sun, Haidong Shu, Junhua Xiao, Wenwu Ye, Yan Wang, Yiming Shuo Shi, Zhen-Zhen Yang, Sanhong Liu, Fan Yang, Wang, Suomeng Dong, Brett M. Tyler, and Yuanchao Wang and Haifan Lin

Contents PNAS u November 3, 2020 u vol. 117 u no. 44 u vii Downloaded by guest on September 28, 2021