VIRTUAL MEETING AGENDA

Monday, March 1, 2021 (Morning)

SESSION I: Eric Green, Director, National Human Genome Research Institute (NHGRI), Session Chair

10:00 a.m. –10:20 a.m. Bert Vogelstein, Co-Director of the Ludwig Center at the Johns Hopkins Kimmel Cancer Center and an Investigator, Howard Hughes Medical Institute

10:20 a.m. –10:25 a.m. Live Q&A

10:30 a.m. –10:50 a.m. Catherine Brownstein, Harvard Medical School and Boston Children’s Hospital

10:50 a.m. –10:55 a.m Live Q&A

11:00 a.m. –11:20 a.m. Josh Denny, Chief Executive Officer of the National Institutes of ​ Health’s All of Us Research Program ​ ​ “Status of All of US”

11:20 a.m. –11:25 a.m. Live Q&A

11:30 p.m. –11:45 p.m. *Alex Swarbrick, Garvan Institute of Medical Research “A Multi-omic single cell and spatial atlas of breast cancer reveals stromal suppression of anti-cancer immunity”

11:45 p.m.–12:00 p.m. *Dylan Swarbrick, Massachusetts Institute of Technology “Robust decomposition of cell type mixtures in spatial transcriptomics”

12:00 p.m. – 12:30 p.m Lunch and Exhibits/Virtual Lab

Monday, March 1, 2021 (Afternoon)

SESSION II: Beth Shapiro, University of California, Santa Cruz, Session Chair

12:30 p.m. – 12:50 p.m. Eddie Holmes, University of Sydney and Sydney Medical School “Zoonoses, and the emergence of SARS-CoV-2”

12:50 p.m. –12:55 p.m Live Q&A

1:00 p.m. – 1:20 p.m. Cheryl Hayashi, Curator, Professor and Director of Comparative Biology Research, American Museum of Natural History

1:20 p.m. –1:25 p.m Live Q&A

Major Sponsor Workshops

1:30 p.m. – 2:15 p.m. NanoString Gold Workshop

Christopher E. Mason, Associate Professor, Department of Physiology and Biophysics, Joseph M. Beechem, Chief Science Officer and Senior Vice President of Research and Development, NanoString Technologies “Progressing spatial biology from tissue architecture to sub cellular functions”

2:15 p.m. – 2:40 p.m. New England Biolabs Silver Workshop

Dr James Hadfield, Director, Epigenomics, AstraZeneca, Oncology Translational Medicine “Benchmarking EM-seq across WGMS, targeted sequencing and EPIC arrays.”

2:45 p.m. – 3:10 p.m. Twist Bioscience Silver Workshop ​ ​

"Success never settles."

3:15 p.m. –4:40 p.m. Beckman Coulter Silver Workshop

Bhagya Wijayawardena, Commercial Product Manager "Discover the next generation of automated NGS library prep—so simple it’s ingenious."

4:40 p.m. –6:00 p.m. Posters

Tuesday, March 2, 2021 (Morning)

SESSION III: Kim Doheny, Johns Hopkins University School of Medicine, Session Chair

10:00 a.m. – 10:20 a.m. Gregg Semenza, Johns Hopkins School of Medicine

“The genetics of oxygen homeostasis”

10:20 a.m. – 10:25 a.m Live Q&A

10:30 a.m. – 10:50 a.m. Eimear Kenny, Icahn School of Medicine at Mount Sinai

10:50 a.m. – 10:55 a.m Live Q&A ​ 11:00 a.m. –11:20 a.m. Mark Daly, Massachusetts General Hospital and Harvard Medical School

11:20 a.m. –11:25 a.m. Live Q&A

11:30 a.m. – 11:45 a.m. *Jason Klein, University of Washington “A systematic evaluation of the design and context dependencies of massively parallel reporter assays”

11:45 a.m. – 12:00 p.m. *Andrew Yang, Department of Neurology, Stanford University “A Spatial Transcriptome Atlas of the Human Brain Vasculature in Alzheimer’s Disease”

12:00 p.m. – 12:30 p.m. Lunch and Exhibits/Virtual Lab

Tuesday, March 2, 2021 (Afternoon)

SESSION IV: John McPherson, University of California, Davis, Session Chair

12:30 p.m. – 12:50 p.m. Jef Boeke, Founding Director of the Institute for Systems Genetics at Langone Medical Center

12:50 p.m. – 12:55 p.m Live Q&A

1:00 p.m. – 1:20 p.m Neville Sanjana, New York Genome Center and New York University ​

“New frontiers in pooled CRISPR screens”

1:20 p.m. – 1:25 p.m Live Q&A

Bronze Sponsor Talks

1:30 p.m. – 1:50 p.m. PacBio

Dr. Jonas Korlach, Chief Scientific Officer, PacBio "Increasing the solve rate of rare and undiagnosed genetic diseases with HiFi sequencing"

1:5O p.m. – 2:10 p.m. Qiagen

Jörg Tost, Director, Laboratory for Epigenetics and Environment (LEE), Centre National de Recherche en Génomique Humaine, CEA - Institut de biologie François Jacob, Université Paris-Saclay "Highly multiplexed targeted DNA methylation analysis"

2:10 p.m. – 2:30 p.m. 10X

2:30 p.m. – 2:45 p.m. Vizgen

Terry Lo, President & CEO, Vizgen "Mapping the Future with Spatial Genomics"

2:45 p.m. – 3:00 p.m. DNA Script

Thomas Ybert, CEO and cofounder, DNA Script "Benchtop enzymatic DNA synthesis delivers on demand oligos to enable confidential research, same-day discovery"

3:00 p.m. – 3:15 p.m. ROSALIND

3:15 p.m. – 3:30 p.m. Codexis

Justin Dassie, Associate Director, Business Development "Next generation enzymes for next generation life science tools"

3:30 p.m. – 5:30 p.m. Posters

Wednesday, March 3, 2021 (Morning)

SESSION V: Martin Hirst, University of British Columbia, Session Chair

10:00 a.m. –10:20 a.m. Samantha Morris, Washington University School of Medicine

“New single-cell technologies to dissect reprogramming and development”

10:20 a.m. –10:25 a.m. Live Q&A

10:30 a.m. –10:50 a.m. John Greally, Albert Einstein College of Medicine and New York Genome Center

“Thinking outside the creode: epigenomics and human disease”

10:50 a.m. –10:55 a.m. Live Q&A

11:00 a.m. –11:20 a.m. Detlev Arendt, European Molecular Biology Laboratory (EMBL)

11:20 a.m. –11:25 a.m. Live Q&A

11:30 p.m. –12:00 p.m. Flash Talks-Highlighted abstract selected by our Scientific Organizing Committee

Domenic Abbondanza, of MIT and Harvard Spatial insights of lung pathology in COVID-19 autopsies

Olga Amosova, Armonica Technologies Novel Enhancement Structures for Surface-Enhanced Raman Scattering from DNA: A Chemically Specific Approach to Single Base Resolution for Long-Read Sequencing

Andrey Bzikadze, UC San Diego Human centromeres: from first automated assemblies to structural characterization and evolutionary analysis

Carlos Cruchaga, Washington University School of Medicine Genomic and Multi-Tissue Proteomic Integration for Understanding the Biology of Disease and other Complex Traits

Joanna Kelley, Washington State University Multi-omics approach to identifying selection on regulatory regions

Joakim Lundeberg, SciLifeLab, KTH Royal Institute of Technology Spatial Isoform Transcriptomics – exploring the isoform landscape in situ

Neil Miller, Center for Pediatric Genomic Medicine- Children’s Mercy Hospital

Accurate long-read whole-genome sequencing of 80 pediatric rare disease cases identifies diagnostic variants missed with short reads

Jessica Nordlund, Uppsala University Multi-omics classification for subtype decision in B-other pediatric acute lymphoblastic leukemia

Kathryn Phillips, University of California San Francisco Building the Evidence Base for Appropriate and Efficient Implementation of Emerging Genomic Tests for Disease Management and Screening

Kalie Wang, MD Anderson Cancer Center Single Nucleus Sequencing Identifies Spatial Reprogramming of the Microenvironment in Premalignant Breast Cancer

12:00 p.m.–12:30 p.m. Lunch and Exhibits/Virtual Lab

Wednesday, March 3, 2021 (Afternoon)

SESSION VI: Stacey Gabriel, Broad Institute of MIT and Harvard, Session Chair

12:30 p.m. – 12:50 p.m. Jin Billy Li, Stanford “RNA editing plays a primary role in common autoimmune and immune-related diseases”

12:50 p.m. – 12:55 p.m. Live Q&A

1:00 p.m. – 1:15 p.m. *Christopher E. Mason, Weill Cornell Medicine “High-plex spatial profiling of COVID-19 lung tissue reveals alterations in interferon signaling associated with high COVID infection distinct from Influenza infection”

1:15 p.m. – 1:30 p.m. *Jinyue Liu, Genome Institute of Singapore “Integrative analysis of single-cell transcriptomics with multiplexed RNA imaging for mapping autism pathophysiology”

Bronze Sponsor Talks

1:45 p.m. – 2:00 p.m. Perkin Elmer

Todd Gierahn, PhD, Honeycomb Chief Scientific Officer "Integrating sample storage & single cell profiling"

2:00 p.m. – 2:15 p.m. Rebus

Brett Cook, Senior Product Manager, Rebus Biosystems "An integrated, automated platform for single-cell spatial omics across full tissues"

2:15 p.m. – 2:30 p.m. Illumina

Jeremy Preston, PhD, Vice President, Regional Marketing, Illumina "The era of genomics accessibility"

2:30 p.m. – 2:45 p.m. IDT

Oliver A. Hampton, Vice President of and Biostatistics, M2GEN "M2GEN’s ORIEN Avatar® program accelerates the discovery, development, and delivery of comprehensive oncology research with a custom xGen™ Exome Research Panel"

2:45 p.m. – 3:00 p.m. Twinstrand

Jesse Salk MD, PhD, Chief Executive Officer, Chief Scientific Officer, Board Member "Ultra-sensitive suplex sequencing for tracking of allogeneic cell therapies"

SESSION VII: Beth Shapiro, University of California, Santa Cruz, Session Chair

3:15 p.m. – 3:40 p.m. Jeffrey Barrett, Director of the COVID-19 Genomics Initiative at the Wellcome Sanger Institute

3:40 p.m. – 3:45 p.m. Live Q&A

3:45 p.m. – 4:10 p.m. Natalie Prystajeck, British Columbia Centre for Disease Control Public Health Laboratory

4:10 p.m. – 4:15 p.m. Live Q&A

4:15 p.m . – 4:40 p.m. Trevor Bedford, Vaccine and Infectious Disease Division, Fred Hutch

4:40 p.m. – 4:45 p.m. Live Q&A

4:45 p.m. – 5:10 p.m. Eddie Holmes, University of Sydney and Sydney Medical School

5:10 p.m. – 5:15 p.m. Live Q&A