Cell adhesion molecules (CAMs) all genes sink node genes ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●●●●●● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●●● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ●●● ● ● ●● ●●● ● ● ● ● maximum = 10 maximum = 4 2 1 s>

10 0

0 10 log −1 −2

group 1 group 2 group 3 group 4 group 5 group 6 group 7 group 8 Cell_adhesion_molecules_CAMs genes with data

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs sink nodes

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs group 1

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs group 2

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs group 3

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs group 4

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs group 5

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs group 6

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs group 7

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN Cell_adhesion_molecules_CAMs group 8

NECTIN1 NECTIN3 CLDN24 CLDN24 CLDN24 CLDN24 NRCAM F11R F11R NECTIN3 NECTIN1 SDC1 OCLN OCLN OCLN OCLN CD58 CD2 CD2 CD58 NFASC ICAM3 CDH2 CDH2 CD28 CD80 F11R F11R VSIR IGSF11 F11R F11R NCAM1 NCAM1 NFASC CNTN1 CD274 CD86 ITGAL ICAM1 NECTIN1 NECTIN1 CD274 CNTNAP1 JAM2 JAM2 ITGB2 L1CAM L1CAM HLA−A CDH1 CDH1 CD80 CD28 JAM3 JAM3 ITGAM CD8A ICAM2 CADM1 CADM1 CADM1 CADM1 CD86 CTLA4 ITGB2 CNTN2 CNTN2 ESAM ESAM CNTNAP2 ITGAL NEGR1 NEGR1 102723996 ICOS ICAM1 ITGB2 JAM3 JAM3 CDH5 CDH5 NTNG1 LRRC4C CD40LG CD40 HLA−DMA ITGA4 PECAM1 PECAM1 JAM2 ITGB1 NTNG2 LRRC4 CD226 PVR CD4 CD99 CD99 PTPRF LRRC4B TIGIT NECTIN2 ITGA9 VCAM1 MPZ MPZ HLA−A NECTIN3 ITGB1 SDC1 SDC1 MAG MAG CD8A ITGA4 ITGAV CDH1 CDH1 ITGB7 ITGB8 CDH1 CDH1 CD274 CDH2 CDH2 ITGA8 PDCD1LG2 PDCD1 CD2 CD58 MADCAM1 NECTIN3 NECTIN2 ITGB1

CD276 CD28 CD80 SELL ITGA6 NRXN3 NLGN4Y ITGB1 CD34 VTCN1 CD274 CD86 ITGAM NRCAM JAM3 ITGB2 CD40 CD40LG VCAN NFASC SELPLG SELP HLA−DMA SELPLG SELP ALCAM CD6 CNTN1 CD4 CADM3 CADM3 CD40 CD40LG GLG1 SELE NECTIN1 NECTIN3 PVR CD226 NFASC CNTN1 CD40LG CD40 ITGAL NRCAM CNTN1 CNTNAP1 NECTIN3 NECTIN1 NECTIN2 TIGIT ICAM2 PECAM1 PECAM1 ITGB2 CNTN1 CD274 PTPRM PTPRM CDH3 CDH3 CD226 CD99 CD99 PDCD1 PDCD1LG2 CNTN2 CNTN2 ITGAL NCAM1 NCAM1 ICAM1 CNTNAP2 ITGB2 ITGAL ICAM1 PVR ITGB2 CD226 CNTN2 CNTN2 CDH2 CDH2 ITGAL ICAM1 F11R F11R NECTIN2 ITGB2 ITGAL CDH4 CDH4 ICAM1 L1CAM L1CAM ITGB2 CD40LG CD40 CDH15 CDH15 CD22 PTPRC CD2 CD58 CLDN11 CLDN11 PTPRC CD22 PECAM1 PECAM1 CDH2 CDH2 NEO1

SIGLEC1 SPN