ATAGENIX LABORATORIES
Catalog Number:ATP123 Anti PON3 polyclonal antibody
Product overview product name Anti PON3 polyclonal antibody catalog No. ATP123
Category Primary antibody
Host Rabbit
Species specificity Human,other species was not test
Tested applications ICC:1:50~200,IHC:1:50~100
Clonality Polyclonal
Conjugation Unconjugated
Immunogen Recombinant protein of human PON3(Leu22-Leu354).
Alternative Names Serum paraoxonase/lactonase 3,PON3
Uniprot ID Q15166
Product performance
Form Liquid
Buffer PBS,pH7.4,containing 0.05% proclin300,50% glycerol.
Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4°C
for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.
Concentration 0.79mg/ml
Isotype IgG
MW 40kDa
Purity Antigen affinity purification
Dilution range
ICC,IHC
Product experiment picture
Web:www.atagenix.com E-mail: [email protected] Tel: 027-87433958 ATAGENIX LABORATORIES
Catalog Number:ATP123 Anti PON3 polyclonal antibody
Reference
PMID: 15772423;PMID: 16335952;PMID: 32092131
Product background
Paroxon is an organophosphorus anticholinesterase compound, used topically in the treatment of glaucoma. It is produced in vivo in mammals by microsomal oxidation of the insecticide parathion. Parathion is inert until transformed to paroxon.
Paroxonase or PON is an arylesterase that is capable of hydrolyzing paroxon to produce p-nitrophenol. PONs are nonspecific and their classification is based not only on substrate specificity but also on tissue distribution, inhibition properties and physicochemical characteristics such as electrophoretic mobility and molecular weight. In contrast to PON1, which is expressed mainly in the liver, PON2 is expressed in a variety of mouse tissues, including the pancreas. PON3 is a associated with the high density lipoprotein fraction of serum. The genes which encode PON1-3 are physically linked and map to human chromosome
7q21.3.
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