Sudden Death in Epilepsy: Insights from the Last 25 Years

Accepted Manuscript

Title: Sudden Death in Epilepsy: Insights from the last 25 years

Author: Lliwen A. Jones Rhys H. Thomas

PII: S1059-1311(16)30170-4 DOI: http://dx.doi.org/doi:10.1016/j.seizure.2016.10.002 Reference: YSEIZ 2803

To appear in: Seizure

Received date: 30-8-2016 Accepted date: 3-10-2016

Please cite this article as: Jones Lliwen A, Thomas Rhys H.Sudden Death in Epilepsy: Insights from the last 25 years.SEIZURE: European Journal of Epilepsy http://dx.doi.org/10.1016/j.seizure.2016.10.002

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Sudden Death in Epilepsy: Insights from the last 25 years

Lliwen A Jones,1 Rhys H Thomas1,2 1. Department of Neurology, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, United Kingdom 2. Institute of Psychological Medicine and Clinical Neurosciences, Hadyn Ellis Building, Maindy Road, Cardiff University, CF24 4HQ, United Kingdom

Corresponding author: Dr Rhys H Thomas Clinical Lecturer in Neurology Institute of Psychological Medicine and Clinical Neurosciences Hadyn Ellis Building Maindy Road Cardiff University CF24 4HQ, United Kingdom [email protected]

Highlights

 SUDEP is the leading cause of mortality in chronic refractory epilepsy  Pathophysiology remains poorly understood but risk factors identified  No proven intervention for its prevention  Increasing awareness and research in the last 25 years  Several promising future research avenues to minimise SUDEP impact