JOURNAL OF VIROLOGY

Volume 68 March 1994 No. 3

ANIMAL VIRUSES Nucleocapsid-Glycoprotein Interactions Required for Susana Lopez, Jian-sheng Yao, 1316-1323 Assembly of Alphaviruses Richard J. Kuhn, Ellen G. Strauss, and James H. Strauss The Presence of Tat Protein or Tumor Necrosis Factor Waldemar Popik and Paula M. 1324-1333 Alpha Is Critical for Virus Type 1-Induced Pitha Expression of Human Immunodeficiency Virus Type 1 Phosphorylation of Varicella-Zoster Virus Open Reading Teresa I. Ng, Lawrence Keenan, 1350-1359 Frame (ORF) 62 Regulatory Product by Viral ORF Paul R. Kinchington, and Charles 47-Associated Protein Kinase Grose Targeting of a Multicomponent Transcription Apparatus Yifan Zhang, Byung-Yoon Ahn, 1360-1370 into Assembling Virus Particles Requires RAP94, and Bernard Moss an RNA Polymerase-Associated Protein Borna Disease Virus (BDV), a Nonsegmented RNA Virus, Beatrice Cubitt and Juan C. de la 1371-1381 Replicates in the Nuclei of Infected Cells Where Infectious Torre BDV Ribonucleoproteins Are Present Sequence and Genome Organization of Borna Disease Virus Beatrice Cubitt, Christopher 1382-1396 Oldstone, and Juan Carlos de la Torre Use of an Autonomous Parvovirus Vector for Selective Francis Dupont, Liliane 1397-1406 Transfer of a Foreign Gene into Transformed Human Cells Tenenbaum, Lan-Ping Guo, Pierre of Different Tissue Origins and Its Expression Therein Spegelaere, Marc Zeicher, and Jean Rommelaere Virus NS1 Protein Stimulates Translation of the Kazue Enami, Takeshi A. Sato, 1432-1437 Ml Protein Susumu Nakada, and Masayoshi Enami Inhibition of Murine AIDS (MAIDS) Development by the Yoshiaki Nakagawa, Kazuhiro 1438-1441 Transplantation of Bone Marrow Cells Carrying the Fv-4 Kakimi, Wang Ling, Yoshinao Resistance Gene to MAIDS Virus-Infected Mice Kubo, Kyoko Higo, Toru Masuda, Kagemasa Kuribayashi, Michihiro Iwashiro, Yosuke Komatz, Toshiyasu Hirama, Akio Adachi, and Akinori Ishimoto Activities of the Feline Immunodeficiency Virus Comelis Vink, Karin H. van der 1468-1474 Protein Produced in Escherichia coli Linden, and Ronald H. A. Plasterk Subcellular Distribution of Human Immunodeficiency Virus Karl-H. Kalland, Anne Marie 1475-1485 Type 1 Rev and Colocalization of Rev with RNA Splicing Szilvay, Erik Langhoff, and Factors in a Speckled Pattern in the Nucleoplasm Gunnar Haukenes Recombinant Influenza Virus Polymerase: Requirement of Moira Hagen, Thomas D. Y. 1509-1515 both 5' and 3' Viral Ends for Endonuclease Activity Chung, J. Alan Butcher, and Mark Krystal Functional Analysis of N-Linked Glycosylation Mutants Ghalib Alkhatib, Shi-Hsiang Shen, 1522-1531 of the Virus Fusion Protein Synthesized by Dalius Briedis, Christopher Recombinant Vaccinia Virus Vectors Richardson, Bernard Massie, Randall Weinberg, Darlene Smith, Jill Taylor, Enzo Paoletti, and John Roder Influenza A Virus M2 Ion Channel Protein: a Leslie J. Holsinger, Deepali 1551-1563 Structure-Function Analysis Nichani, Lawrence H. Pinto, and Robert A. Lamb

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pet, a Small Sequence Distal to the Pregenome Cap Site, Mingjun Huang and Jesse 1564-1572 Is Required for Expression of the Duck Summers Pregenome A New Subtype of Human Immunodeficiency Virus Type 1 Lutz G. Gurtler, Peter H. Hauser, 1581-1585 (MVP-5180) from Cameroon Josef Eberle, Albrecht von Brunn, Stefan Knapp, Leopold Zekeng, Jean M. Tsague, and Lazare Kaptue Genomic Cloning and Complete Sequence Analysis of a Marleen Vanden Haesevelde, 1586-1596 Highly Divergent African Human Immunodeficiency Virus Jean-Luc Decourt, Robert J. De Isolate Leys, Bart Vanderborght, Guido van der Groen, Hugo van Heuverswijn, and Eric Saman Minimal Sequence Requirements of a Functional Human John K. Wakefield, Hyangshuk 1605-1614 Immunodeficiency Virus Type 1 Primer Binding Site Rhim, and Casey D. Morrow Hormonal Regulation of the Gene for the Type C Ecotropic Jin Yun Wu, Dan Robinson, 1615-1623 Receptor in Rat Liver Cells Hsing-Jien Kung, and Maria Hatzoglou Genetic Analysis of the Human Immunodeficiency Virus Cha-Gyun Shin, Brunella Taddeo, 1633-1642 Type 1 Integrase Protein William A. Haseltine, and Chris M. Farnet Mapping a Region of the Large Envelope Protein Required Volker Bruss and Reiner 1643-1650 for Hepatitis B Virion Maturation Thomssen Proteolytic Cleavage of Bovine Herpesvirus 1 (BHV-1) Annegret Kopp, Earl Blewett, 1667-1674 Glycoprotein gB Is Not Necessary for Its Function in BHV-1 Vikram Misra, and Thomas C. or Pseudorabies Virus Mettenleiter Rearrangement of the VP6 Gene of a Group A in Shuo Shen, Bernard Burke, and 1682-1688 Combination with a Point Mutation Affecting Trimer Ulrich Desselberger Stability Role of the Matrix Protein in the Virion Association of the Tatyana Dorfman, Fabrizio 1689-1696 Human Immunodeficiency Virus Type 1 Envelope Mammano, William A. Haseltine, Glycoprotein and Heinrich G. Gottlinger Identification and Characterization of a Human Herpesvirus Jinhai Wang, Clinton Jones, 1706-1713 6 Gene Segment Capable of Transactivating the Human Michael Norcross, Ernst Bohnlein, Immunodeficiency Virus Type 1 Long Terminal Repeat in and Abdur Razzaque an Spl Binding Site-Dependent Manner Cysteine Residues in the Vif Protein of Human Xiao-Yue Ma, Pavel Sova, Wei 1714-1720 Immunodeficiency Virus Type 1 Are Essential for Chao, and David J. Volsky Viral Infectivity Identification and Characterization of a Protein Kinase Gene David S. Bischoff and James M. 1728-1736 in the Lymantria dispar Multinucleocapsid Nuclear Slavicek Polyhedrosis Virus An 85-Kilodalton Herpes Simplex Virus Type 1 a J. L. C. McKnight, M. Doerr, and 1750-1757 trans-Induction Factor (VP16)-VP13/14 Fusion Protein Y. Zhang Retains the Transactivation and Structural Properties of the Wild-Type Molecule during Virus Infection Repression of Enhancer H Activity by a Negative Regulatory Wei-Yu Lo and Ling-Pai Ting 1758-1764 Element in the Hepatitis B Virus Genome Function of-the Cytoplasmic Domain of a Retroviral Alan Rein, Jane Mirro, Jacqueline 1773-1781 Transmembrane Protein: pl5E-p2E Cleavage Activates the Gordon Haynes, Sandra M. Ernst, Membrane Fusion Capability of the and Kunio Nagashima Protein Viral Multiplicity of Attachment and Its Implications for John L. Spouge 1782-1789 Human Immunodeficiency Virus Therapies

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Antigenicity of the N8 Influenza A Virus Neuraminidase: T. Saito, G. Taylor, W. G. Laver, 1790-1796 Existence of an Epitope at the Subunit Interface of the Y. Kawaoka, and R. G. Webster Neuraminidase Splice Site Selection in Polyomavirus Late Pre-mRNA David B. Batt, Lisa M. Rapp, and 1797-1804 Processing Gordon G. Carmichael Mutational Analysis of the Conserved Motifs of Influenza A Siddhartha K. Biswas and Debi P. 1819-1826 Virus Polymerase Basic Protein 1 Nayak Regulation of Sindbis Virus RNA Replication: Uncleaved Yukio Shirako and James H. 1874-1885 P123 and nsP4 Function in Minus-Strand RNA Synthesis, Strauss whereas Cleaved Products from P123 Are Required for Efficient Plus-Strand RNA Synthesis Molecular Evolution of Herpesviruses: Genomic and Protein Samuel Karlin, Edward S. 1886-1902 Sequence Comparisons Mocarski, and Gabriel A. Schachtel Sequence Requirements of the Epstein-Barr Virus Latent Sarah Harrison, Kimberly Fisenne, 1913-1925 Origin of DNA Replication and Janet Hearing Requirement of the Pr559'a Precursor for Incorporation of Claude Lavallee, Xiao Jian Yao, 1926-1934 the Product into Human Immunodeficiency Virus Azim Ladha, Heinrich Gottlinger, Type 1 Viral Particles William A. Haseltine, and Eric A. Cohen Structure of Intracellular Mature Vaccinia Virus Observed Jacques Dubochet, Marc Adrian, 1935-1941 by Cryoelectron Microscopy Karsten Richter, Javier Garces, and Riccardo Wittek Enhanced In Vitro Human Immunodeficiency Virus Type 1 Yoshihiko Tani, Eileen Donoghue, 1942-1950 Replication in B Cells Expressing Surface Antibody to the Sandra Sharpe, Elizabeth Boone, TM Env Protein H. Clifford Lane, Susan Zolla-Pazner, and David I. Cohen Photoinactivation and Kinetics of Membrane Fusion D. S. Dimitrov and R. Blumenthal 1956-1961 Mediated by the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein The Phorbol Ester Phorbol Myristate Acetate Inhibits Hana Golding, Jody Manischewitz, 1962-1969 Human Immunodeficiency Virus Type 1 Envelope-Mediated Luba Vujcic, Robert Blumenthal, Fusion by Modulating an Accessory Component(s) in and Dimiter S. Dimitrov CD4-Expressing Cells Redesignation of the RNase D Activity Associated with Zdenek Hostomsky, Stephen H. 1970-1971 Retroviral as RNase H* Hughes, Stephen P. Goff, and Stuart F. J. Le Grice The Activity of the Pseudorabies Virus Latency-Associated C. J. Huang, M. K. Rice, G. B. 1972-1976 Transcript Promoter Is Dependent on Its Genomic Location Devi-Rao, and Edward K. Wagner in Herpes Simplex Virus Recombinants as well as on the Type of Cell Infected gp120-Independent Fusion Mediated by the Human Luisa Marcon and Joseph Sodroski 1977-1982 Immunodeficiency Virus Type 1 gp4l Envelope Glycoprotein: a Reassessment Varicella-Zoster Virus Open Reading Frame 4 Protein Is Hiroyuki Moriuchi, Masako 1987-1992 Functionally Distinct from and Does Not Complement Its Moriuchi, Holly A. Smith, and Herpes Simplex Virus Type 1 Homolog, ICP27 Jeffrey I. Cohen Analysis of Tat Function in Human Immunodeficiency Virus Paula Cannon, Seon-Hee Kim, 1993-1997 Type 1-Infected Low-Level-Expression Cell Lines Ul and Catherine Ulich, and Sunyoung ACH-2 Kim Posttranscriptional Effector Domains in the Rev Proteins of Victoria A. Mancuso, Thomas J. 1998-2001 Feline Immunodeficiency Virus and Equine Infectious Hope, Li Zhu, David Derse, Tom Anemia Virus Phillips, and Tristram G. Parslow Functional Role of the Zipper Motif Region of Human Steve S.-L. Chen 2002-2010 Immunodeficiency Virus Type 1 Transmembrane Protein gp4l

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Intermediates of Adeno-Associated Virus DNA Replication G. Hong, P. Ward, and K. I. 2011-2015 In Vitro Bems Characterization of Human Immunodeficiency Virus Type 1 David D. Ho, Takuo Toyoshima, 2016-2020 Variants with Increased Resistance to a C2-Symmetric Hongmei Mo, Dale J. Kempf, Protease Inhibitor Daniel Norbeck, Chih-ming Chen, Norman E. Wideburg, Stan K. Burt, John W. Erickson, and Mandaleshwar K. Singh Woodchuck Hepatitis Virus X Protein Is Required for Viral Fabien Zoulim, Jeffrey Saputelli, 2026-2030 Infection In Vivo and Christoph Seeger Upstream U3 Sequences in Simian Immunodeficiency Virus Frank Kirchhoff, Harry W. Kestler 2031-2037 Are Selectively Deleted In Vivo in the Absence of an Intact III, and Ronald C. Desrosiers Gene

VIRUS-CELL INTERACTIONS Interleukin-2 and Alpha/Beta Interferon Down-Regulate Luca G. Guidotti, Stephane 1265-1270 Hepatitis B Virus Gene Expression In Vivo by Tumor Guilhot, and Francis V. Chisari Necrosis Factor-Dependent and -Independent Pathways A Monoclonal Antibody That Blocks Poliovirus Attachment Michael P. Shepley and Vincent R. 1301-1308 Recognizes the Lymphocyte Homing Receptor CD44 Racaniello Neutralization Sensitivity of Human Immunodeficiency Virus Lynette S. W. Sawyer, M. Terri 1342-1349 Type 1 Is Determined in Part by the Cell in Which the Wrin, Leta Crawford-Miksza, Virus Is Propagated Barbara Potts, Yaming Wu, Patricia A. Weber, Ryan D. Alfonso, and Carl V. Hanson Giardiavirus-Resistant Giardia lamblia Lacks a Virus T. Sepp, A. L. Wang, and C. C. 1426-1431 Receptor on the Cell Membrane Surface Wang Down-Regulation of HLA Antigens by the Adenovirus Type Heinrich K6rner and 1442-1448 2 E3/19K Protein in a T-Lymphoma Cell Line Hans-Gerhard Burgert An Epstein-Barr Virus with a 58-Kilobase-Pair Deletion Erle S. Robertson, Blake 1449-1458 That Includes BARFO Transforms B Lymphocytes In Vitro Tomkinson, and Elliott Kieff Translational Frameshifting at the gag- Junction of Michel Cassan, Nathalie Delaunay, 1501-1508 Human Immunodeficiency Virus Type 1 Is Not Increased Catherine Vaquero, and in Infected T-Lymphoid Cells Jean-Pierre Rousset Internal Translation Initiation on Poliovirus RNA: Further Yuri V. Svitkin, Karen 1544-1550 Characterization of La Function in Poliovirus Translation In Meerovitch, Han S. Lee, Jaydev Vitro N. Dholakia, Daniel J. Kenan, Vadim I. Agol, and Nahum Sonenberg Induction of Endogenous Human Cytomegalovirus Gene Jean Taylor-Wiedeman, Patrick 1597-1604 Expression after Differentiation of Monocytes from Healthy Sissons, and John Sinclair Carriers Comparison of the Effects of Sindbis Virus and Sindbis Ilya Frolov and Sondra Schlesinger 1721-1727 Virus Replicons on Host Cell Protein Synthesis and Cytopathogenicity in BHK Cells Analysis of the Signals for Polarized Transport of Influenza Amitabha Kundu and Debi P. 1812-1818 Virus (A/WSN/33) Neuraminidase and Human Transferrin Nayak Receptor, Type II Transmembrane Proteins Reduced Nuclear Import of Human Immunodeficiency Virus J. Gulizia, M. P. Dempsey, N. 2021-2025 Type 1 Preintegration Complexes in the Presence of a Sharova, M. I. Bukrinsky, L. Prototypic Nuclear Targeting Signal Spitz, D. Goldfarb, and M. Stevenson

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VIRAL AND CELLULAR ONCOGENES Identification of Evi-3, a Novel Common Site of Retroviral Monica J. Justice, Herbert C. 1293-1300 Integration in Mouse AKXD B-Cell Lymphomas Morse III, Nancy A. Jenkins, and Neal G. Copeland Alterations of the p53 Gene in Epstein-Barr Rachel Hood Edwards and Nancy 1309-1315 Virus-Associated Immunodeficiency-Related Lymphomas Raab-Traub The Amino-Terminal Functions of the Simian Virus 40 Robin S. Quartin, Charles N. Cole, 1334-1341 Large T Antigen Are Required To Overcome Wild-Type James M. Pipas, and Arnold J. p53-Mediated Growth Arrest of Cells Levine Mutations Which Affect the Inhibition of Protein Shubhangee Mungre, Kristine 1675-1681 Phosphatase 2A by Simian Virus 40 Small-t Antigen In Enderle, Ben Turk, Analia Porra's, Vitro Decrease Viral Transformation Yun-Qi Wu, Marc C. Mumby, and Kathleen Rundell A Ca2+/Calmodulin-Dependent Protein Kinase, CaM George Mosialos, Silva H. 1697-1705 Kinase-Gr, Expressed after Transformation of Primary Hanissian, Satya Jawahar, Lisa Human B Lymphocytes by Epstein-Barr Virus (EBV) Is Vara, Elliott Kieff, and Talal A. Induced by the EBV Oncogene LMP1 Chatila Role of Oligomerization of the S13 Env-Sea Oncoprotein Alyssa M. Morimoto and Michael 1837-1842 in Cell Transformation J. Hayman

PROTOZOAN AND FUNGAL VIRUSES Killer Toxin-Secreting Double-Stranded RNA Mycoviruses Manfred J. Schmitt and Frank 1765-1772 in the Yeasts Hanseniaspora uvarum and Zygosaccharomyces Neuhausen bailii

VIRAL PATHOGENESIS AND IMMUNITY Herpes Simplex Virus Type 1 DNA Replication and Gene G. B. Devi-Rao, D. C. Bloom, 1271-1282 Expression during Explant-Induced Reactivation of Latently J. G. Stevens, and E. K. Wagner Infected Murine Sensory Ganglia Molecular Analysis of Herpes Simplex Virus Type 1 during D. C. Bloom, G. B. Devi-Rao, 1283-1292 Epinephrine-Induced Reactivation of Latently Infected J. M. Hill, J. G. Stevens, and Rabbits In Vivo E. K. Wagner Antigenic Heterogeneity of a Foot-and-Mouth Disease Virus M. G. Mateu, J. Hernaindez, M. A. 1407-1417 Serotype in the Field Is Mediated by Very Limited Sequence Martinez, D. Feigelstock, S. Lea, Variation at Several Antigenic Sites J. J. Perez, E. Giralt, D. Stuart, E. L. Palma, and E. Domingo Antibody and Cytotoxic T-Cell Responses to Soluble Reinhold Schirmbeck, Karl 1418-1425 Hepatitis B Virus (HBV) S Antigen in Mice: Implication Melber, Thomas Mertens, and for the Pathogenesis of HBV-Induced Hepatitis Jorg Reimann Major Histocompatibility Complex-Restricted CD8+ Travis C. McGuire, Daniel B. 1459-1467 Cytotoxic T Lymphocytes from Horses with Equine Tumas, Katherine M. Byrne, Infectious Anemia Virus Recognize Env and Gag/PR Melissa T. Hines, Steven R. Leib, Proteins Alberta L. Brassfield, Katherine I. O'Rourke, and Lance E. Perryman Antigenic Determinants of Measles Virus Hemagglutinin Uwe G. Liebert, S. G. Flanagan, 1486-1493 Associated with Neurovirulence S. L6ffler, K. Baczko, V. ter Meulen, and B. K. Rima Neutralizing Antibodies against Virus and the Yohko K. Shimizu, Minako 1494-1500 Emergence of Neutralization Escape Mutant Viruses Hijikata, Aikichi Iwamoto, Harvey J. Alter, Robert H. Purcell, and Hiroshi Yoshikura

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Spontaneous Development of Anti-Hepatitis B Virus Kurt Hertogs, Erik Depla, T. 1516-1521 Envelope (Anti-Idiotypic) Antibodies in Animals Immunized Crabbe, Wieke De Bruin, William with Human Liver Endonexin II or with the F(ab')2 Leenders, Han Moshage, and Sing Fragment of Anti-Human Liver Endonexin H Hiem Yap Immunoglobulin G: Evidence for a Receptor-Ligand-Like Relationship between Small Hepatitis B Surface Antigen and Endonexin II Transcription Inhibition and Other Properties of Matrix Kalachar Suryanarayana, Knut 1532-1543 Proteins Expressed by M Genes Cloned from Measles Baczko, Volker ter Meulen, and Viruses and Diseased Human Brain Tissue Robert R. Wagner Characterization of T-Helper Epitopes of the Glycoprotein Christoph Burkhart, Giulia Freer, 1573-1580 of Vesicular Stomatitis Virus Rodrigo Castro, Luciano Adorini, Karl-Heinz Wiesmuller, Rolf M. Zinkemagel, and Hans Hengartner Mucosal Model of Genital Immunization in Male Rhesus Thomas Lehner, Louisa Tao, 1624-1632 Macaques with a Recombinant Simian Immunodeficiency Christina Panagiotidi, Linda S. Virus p27 Antigen Klavinskis, Roger Brookes, Luma Hussain, Nicola Meyers, Sally E. Adams, Andy J. H. Gearing, and Lesley A. Bergmeier Enhanced Replication of a Hepatitis B Virus Mutant Kiyoshi Hasegawa, Jiakang Huang, 1651-1659 Associated with an Epidemic of Fulminant Hepatitis Steven A. Rogers, Hubert E. Blum, and T. Jake Liang Nevirapine Resistance Mutations of Human Douglas D. Richman, Diane 1660-1666 Immunodeficiency Virus Type 1 Selected during Therapy Havlir, Jacques Corbeil, David Looney, Caroline Ignacio, Stephen A. Spector, John Sullivan, Sarah Cheeseman, Kevin Barringer, Dan Pauletti, Cheng-Kon Shih, Maureen Myers, and Johanna Griffin Multigenic Evasion of Inflammation by Poxviruses Gregory J. Palumbo, R. Mark 1737-1749 Buller, and Wayne C. Glasgow Down-Regulation of Major Histocompatibility Complex Ann E. Campbell and Jacquelyn S. 1805-1811 Class I Synthesis by Murine Cytomegalovirus Early Gene Slater Expression RAZ, an Epstein-Barr Virus Transdominant Repressor That Frank B. Fumari, Valerie Zacny, 1827-1836 Modulates the Viral Reactivation Mechanism E. Byrd Quinlivan, Shannon Kenney, and Joseph S. Pagano Incomplete Protection, but Suppression of Virus Burden, Zimra R. Israel, Paul F. 1843-1853 Elicited by Subunit Simian Immunodeficiency Virus Edmonson, Donald H. Maul, Vaccines Shawn P. O'Neil, Sally P. Mossman, Clotilde Thiriart, Luc Fabry, Omer Van Opstal, Claudine Bruck, Francoise Bex, Arsene Burny, Patricia N. Fultz, James I. Mullins, and Edward A. Hoover Induction of HLA Class I and Class II Expression in Human Tanya J. Lehky, Elliot P. Cowan, 1854-1863 T-Lymphotropic Virus Type I-Infected Neuroblastoma Cells Lois A. Lampson, Steven Jacobson Competitive Quantitative PCR Analysis of Herpes Simplex Ramesh Ramakrishnan, David J. 1864-1873 V'irus Type 1 DNA and Latency-Associated Transcript RNA Fink, Guihua Jiang, Prashant in Latently Infected Cells of the Rat Brain Desai, Joseph C. Glorioso, and Myron Levine Murine AIDS Is Initiated in the Lymph Nodes Draining the Carole Simard, Ming Huang, and 1903-1912 Site of Inoculation, and the Infected B Cells Influence T Paul Jolicoeur Cells Located at Distance, in Noninfected Organs

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Resistance of Lymphocytic Choriomeningitis Virus to Demetrius Moskophidis, Manuel 1951-1955 Alpha/Beta Interferon and to Gamma Interferon Battegay, Marie-Anne Bruendler, Elisabeth Laine, Ion Gresser, and Rolf M. Zinkernagel Induction of Beta Interferon by Human Immunodeficiency Sandra Gessani, Patrizia Puddu, 1983-1986 Virus Type 1 and Its gpl2O Protein in Human Barbara Varano, Paola Borghi, Monocytes-Macrophages: Role of Beta Interferon in Lucia Conti, Laura Fantuzzi, Restriction of Virus Replication and Filippo Belardelli