"Inseticidas de uso doméstico, suas formulações e segurança ao consumidor" Grupo Sumitomo
September 16th, 2011
Shin Iti Fujimori
Marketing Department – International Environmental Health Division Sumitomo Chemical Co., Ltd.
As Empresas do Grupo Sumitomo por Setores As Empresas do Grupo Sumitomo por Setores
Finanças Metais não Ferrosos Química Construções Residenciais The Sumitomo Mitsui Bank, Ltd. Sumitomo Light Metal Industries, Ltd. Sumitomo Chemical Co., Ltd. Sumitomo Forestry Co., Ltd. Sumitomo Bakelite Co., Ltd. The Sumitomo Trust & Banking Co., Ltd. Sumitomo Sitix Corporation Shinto Paint Co., Ltd. Navios e Infraestrutura Portuária Sumitomo Seika Chemicals Co., Ltd. The Sumitomo Warehouse Co., Ltd. Seguros Maquinária Sumitomo Pharmaceuticals Co., Ltd. Sumitomo Life Insurance Company Sumitomo Heavy Industries, Ltd. Sumitomo 3M Limited Imobiliária The Sumitomo Mitsui Marine & Fire Insurance Sumitomo Precision Products Co., Ltd. Sumitomo Realty & Development Co., Ltd. Co.,Ltd. Daikin Industries, Ltd. Borracha Sumitomo Rubber Industries, Ltd. Transporte Marítimo Leasing Alimentação Tokai Rubber Industries, Ltd. Daiichi Chuo Kisen Kaisha Sumisho Lease Co., Ltd. Asahi Breweries Mitsui O. S. K., Lines, Ltd. Vidro e Cerámica Nippon Sheet Glass Co., Ltd. Comércio e Servicos Integrados Eletrónica e Produtos Elétricos Construção e Engenharia Sumitomo Osaka Cement Co., Ltd. Sumitomo Construction Co., Ltd. Sumitomo Corporation Sumitomo Electric Industries, Ltd. Narumi China Corporation Sumitomo Chemical Engineering Co., Ltd. Sumisho Computer Systems Corporation NEC Corporation Nippon Electric Glass Co., Ltd. Sumitomo Denresetsu Co., Ltd. Summit Inc. Sumitomo Special Metals Co., Ltd. Otto-Sumisho Inc. Nissin Electric Co., Ltd. Exploração Petrolífera e Mineradora Meidensha Corporation Sumitomo Metal Mining Co., Ltd. Ferro e Aço Sumitomo Wiring Systems, Ltd. Sumitomo Coal Mining Co., Ltd. Sumitomo Metal Inustries, Ltd. Anritsu Corporation Sumitomo Petroleum Development Co., Ltd
History of Sumitomo Chemical Co. and the beginning of Agricultural Chemicals Business
“Namban-buki” Introduction of copper smelting Innovative copper technology (1590) smelting technology
Production of fertilizer from SO2 recovered in copper smelting operation in order to resolve an environmental pollution problem (1913)
Evolution to crop protection and environmental health businesses
Compatibility between development and environment conservation
6
1 Sumitomo Chemical Corporate Profile Locations of Office, Works and Research Stations
Founded : 1913 OSAKA Net Sales（Consolidated) : US$ 25 billion (2011/3) OSAKA Head Office Number of employees（Consolidated) : 29,382 Osaka Works IT-related Chemicals Research Laboratory Organic Synthesis Research Laboratory Basic Chemicals IT-related Environmental Health Science Process & Product Technology Center Sector Chemicals Sector MISAWA Misawa Works
TAKARAZUKA TSUKUBA Petro Chemicals Health & Crop (Tsukuba Research Laboratory) Health & Crop Sciences Research & Plastics Sector Sciences Sector Laboratory TOKYO Head office CHIBA ¾Crop Protection (Chiba Works, Petrochemicals Research Laboratory, ¾Environmental Health Plastics Technology Center) ¾Vector Control EHIME ¾Animal Nutrition (Ehime Works,Basic Chemicals Research Laboratory, ¾Pharmaceutical Chemicals Process & Production Technology Center, Electronic Devices Development Center) 7 OITA 8 Ohita Works
Global Network of Environmental Health Division
Environmental Health Division Sumitomo Chemical America (NY) Divisão de Saúde Ambiental
Sumitomo Chemical UK Sumitomo Chemical Agro Seoul Valent BioSciences Sumitomo Chemical (ESD) Sumitomo Chemical Shanghai Sumitomo Chemical Taiwan Sumitomo Chemical Valent de Mexico India Sumitomo Chemical Singapore
Sumitomo Chemical Sumitomo Chemical do Brazil Enviro-Agro Asia Pacific
Philagro South Africa Sumitomo Chemical Australia 10
New Molecule Research Center
Sumitomo Chemical Co., Ltd. Agricultural Chemicals Research Lab.
Research and Development
11
2 R&D Process for New Product Research and Development Network for New Compounds -screening-
Environmental Health Science Lab. Organic Synthesis Res. Lab. QSAR/QSPR analysis molecular design evaluation of the possible impact of our Computer simulation products on human health and the developing innovative synthesis environment. (GLP) methods, analysis methods
Health & Crop Sciences Res. Lab. Health & Crop Sciences Res. Lab. Misawa Works synthesis preliminary efficacy test ¾ Discovery of new molecules manufacturing products ¾ Efficacy Evaluation with advanced and ¾ Development of new formulations stable organic synthesis technology high through put screening ¾ Development of new efficacy quality assurance evaluation technology (ISO 9001) behavior observation of insect mode of action analysis
preliminary safety Environmental Health test Process & Production Technology Technology Center (Malaysia） Center development of new industrial Technical service to customers processes through Environmental Health Science engineering safety analysis formulation evaluation and Lab. New Compound efficacy 13 14 evaluation with high quality. (GLP ISO17025)
R&D Process for New Product R&D Process for New Product -practicality assessment- -development- New Compound New Compound
field efficacy test efficacy test toxicological test formulation study marketing feasibility study Environmental Health Health & Crop Sciences Res. Lab. Science Lab. Head Office preliminary formulation long term safety test Environmental Health Division study long term stability test engineering safety test basic manufacturing environmental test process study risk assessment analytical method development Health & Crop Sciences Res. Lab. Environmental Health Science Process & Production Technology Center Lab. Organic Synthesis Res. Lab.
15 16
R&D Process for New Product R&D Process for New Product -registration & launching- -further development- New Compound New Product
manufacturing process manufacturing process new formulation study Submission improvement study
Pilot manufacturing 5 batch analysis
Health & Crop Sciences Res. Lab. Registered Misawa Works Organic Synthesis Res. Lab.
Commercial production customer support
New Product Environmental Health Technology Centre (Malaysia） Misawa Works Launching 17 18
3 Risk Assessment Process for HHI Active Ingredients Data Requirements for Registration Toxicology・Pharmacology・Metabolism Environmental Study Melting points/boiling point Acute oral, dermal or inhalation Single dose tox study Specific gravity/density Skin and eye irritation Repeated dose toxicity Vapor pressure Skin sensitization Reproduction toxicity AI concentration in air Sensitization study Water solubility, fat solubility Repeated dose toxicity Residual AI content on the floor Irritation study AI content on human skin Hydrolysis as function of pH Mutagenicity studies Geno tox study Simulation/experimental Partition coefficient Carcinogenicity ADME study evaluation Adsorppption/desorption Reproduction toxicity Evaluate tox profile Estimate exposure amount Dissociation constant and NOAEL dose in house and worker Particle size distribution Acute fish toxicity Flash point, flammability Daphnia acute toxicity Hazard Assessment Exposure Assessment Auto-ignition temperature Daphnia reproduction Risk Assessment Algae growth inhibition Oxidizing properties Safety Factor（MOS, Margin of Safety） Explosive properties Ready biodegradability ↓ UV-visible, IR, NMR Biodegradation Internal Authorization to launch new product Bioaccumulation Collect New Regulation Information, Globally (ex. VOC regulation, ED)
Technical Journal of Sumitomo Chemical Environmental Health Division Support for Product Safety and Regulation “SP WORLD” Vol.1 (1983) ～ vol.39 (2010)
Life Cycle of Chemical
R&D Registration Manufacturing Distribution Consumption Disposal Introduction of our new products New formulation technology topics ETOC™, SUMITHIRIN™, GOKILAHT™ ¾ Microcapsule technology SUMILARV™, VAPORTHRIN™ ¾ Micro emulsion technology PRALLE™, SumiOne™ ¾ Droplet analysis of WBA PESGUARD™ series, SUMILARV™0.5G ¾ Formulation factor of aerosol in Data and Reports etc. efficacy ¾ Resin emanator etc. Safety & Regulatory topics Risk Assessment Bioefficacy study topics Process hazard analysis, evaluation of environmental effects, ¾ Toxicological studies and safety ¾ Review of various test methods and evaluation of health effects assessment ¾ Quality assessment methods ¾ Mechanism of resistance ¾ Regulatory up-date ¾ Repellency of Pyrethroids etc. ¾ Electric measurement Risk Reduction and Control Scientific review of harmful pests of the Mosquito bite Emission reduction, exposure reduction, ¾ Insect Symptomology and Nerve Responses to Pyrethroid "SP" : Sumitomo Pyrethroid MSDS, packing, and labeling etc. 21 22
® Development of Pynamin from Evolution of Sumitomo's Novel Pyrethroids
Natural-Pyrethrins Natural-Pyrethrins
PYNAMIN™ PYNAMIN™ was firstly 1909 Discovery of Natural-Pyrethrins launched by Sumitomo PYNAMIN™ FORTE Chemical in 1953 1924 Research of Pyrethrin derivatives
NEO- 1947 Structure elucidation of VAPORTHRIN™ SUMITHRIN™ ETOC™ PYNAMIN™ Natural-Pyrethrins GOKILAHT™ NEO-PYNAMIN™ SumiOne™ 1949 Invention of Allethrin FORTE ® 1953 Launch of Pynamin by Sumitomo GOKILAHT™-S PRALLE™ Chemical SUMILARV™, PESGUARD™ Series, SUMITHRIN™ 10SEC, Premixtures for mat/VL etc.
24
4 History of R&D of Household Insecticides Produtos e suas aplicações F F Agentes de volteio(Knockdown agents) Relative potency against Culex quinquefasciatus O H CH2OCH3 Nome comercial Toxicidade aguda (Coil KD test) C O CH3 F F
Insecticide Acti CH3 CH3 Neo-Pynamin LD 40 50 (Tetramethrin) oral (rat) >5,000 mg/kg(IT-0224) ・High Insecticidal Activity Metofluthrin dermal (rabbit) >2,000 mg/kg (IT-0207) 2004 ・Good safety profile Neo-Pynamin Forte LD50 (d-Tetramethrin) oral (rat) >5,000 mg/kg(IT-0086) 5 dermal (rat) >2,000 mg/kg (IT-0086) v CH3 ity (Relative Potency) O CH3 C O LD CH O Pynamin Forte 50 3 oral (rat) 2,150 mg/kg(KT-0079) CH3 CH3 (d-Allethrin) prallethrin 900 mg/kg dermal (rabbit) 2,660 mg/kg (KT-0080) 1 CH3 1988 CH3 O 4,390 mg/kg 0.5 C O CH3 O CH3 O R Etoc LD50 C O CH3 CH3 d-allethrin oral (rat) 640 mg/kg(FFT-0032) CH3 O (Prallethrin) CH CH 1974 460 mg/kg 3 3 R = -CH3, -CO2CH3 pyrethrins dermal (rat) >5,000 mg/kg (FFT-0033) LD ～ Launching Year in Japan 2000 50 1900 Pralle oral (rat) >4,500 mg/kg (Imiprothrin 50%) dermal (rat) >2,000 mg/kg
Produtos e suas aplicações Produtos e suas aplicações
Agentes de volteio(Knockdown agents) Agente matador(Killing Agents) Nome comercial Toxicidade aguda Nome comercial Toxicidade aguda
Bioallethrin LD50 Sumithrin LD50 (BAL) oral (rat) 709 – 1,042 mg/kg (d-Phenothrin) oral (rat) >5,000 mg/kg(ET-0104) dermal (rabbit) >3,000 mg/kg dermal (rat) >2,000 mg/kg (ET-0174)
Esbiothrin LD50 Gokilaht-S LD50 (EBT) oral (rat) 378 - 432 mg/kg (Cyphenothrin-S) oral (rat) 318 mg/kg(EET-0011) dermal (rat) >2,000 mg/kg 419 mg/kg dermal (rat) >5,000 mg/kg (EET-0012)
Sbiol LD50 oral (rat) 413 – 574 mg/kg Vaporthrin LD50 dermal (rabbit) >2,000 mg/kg (Empenthrin) oral (rat) >5,000 mg/kg(BBT-0039) >3,500 mg/kg dermal (rat) >2,000 mg/kg (BBT-0040)
Piretrina LD50 oral (rat) 700 – 2,140 mg/kg (Extrato de Piretro) Premium Sumithion LD50 dermal(rat) >2,000 mg/kg (Fenitrothion) oral (rat) 330 mg/kg (HT-0187) 800 mg/kg dermal (rat) 890 mg/kg (HT-0187) 1,200 mg/kg
Produtos e suas aplicações Produtos e suas aplicações
Agente matador(Killing agents) Regulador de crescimento(Insect Growth Regulators) Nome comercial Toxicidade Aguda Nome comercial Toxicidade aguda
Permethrin LD50 Sumilarv LD50 oral (rat) >20,090 mg/kg(neat) (Pyriproxyfen) oral (rat) >5,000 mg/kg(NNT-0005) dermal (rat) >2,000 mg/kg dermal (rat) >2,000 mg/kg (NNT-0006)
Bioresmethrin LD50 oral (rat) 4,636 – 6,091 mg/kg dermal (rat) >2,000 mg/kg
Deltamethrin LD50 oral (rat) 66.7 to >5,000 mg/kg dermal (rat) >2,000 mg/kg
Cypermethrin LD50 oral (rat) dermal (rat)
5 Inseto Alvo Formulação Produto Inseto Alvo Formulação Produto
Pynamin Forte Aerossol OBA Mosquito Espiral Barata ETOC ETOC WBA Neo-Pynamin Forte Pernilongo Líquido Pralle Muriçoca Pastilha Pynamin Forte Gokilaht-S Pynamin Forte 40 Cypermethrin Etoc Etoc 10 Microcápsula Sumithion MC Vaporizador líquido Etoc Gokilaht MC Etoc 6 Pynamin Forte Bait & Gel Sumithion MC Mosquito Aerosol OBA Neo-Pynamin Forte Mosca WBA Pynamin Forte doméstica Líquido ETOC Fumigador Gokilaht-S Gokilaht-S Permethrin Sumithrin
MEC Pesguard PS 102 EG092 SUM10SEC
Inseto Alvo Formulação Produto Inseto Alvo Formulação Produto
Piolho Shampoo Sumithrin PCO CE Pesguard NS series Tal co Líquido Pesguard NSB series Lendia Permethrin Ácaro Pesguard FG series Loçao Deltamethrin SEC Barata Granulado Sumithion NP series Sumithion MC & MC Gel Mosca WDG Pulga Aerossol Sumilarv/ Gokilaht-S Sumithrin 10 SEC Mosquito Pó Gokilaht MC Spray Sumilarv/Sumithrin Pulga Gel Gokilaht 0,5D Spot-on Sumithrin Aerossol Sumilarv 0,5G & WDG etc. Etc. Ácaro Shampoo Sumithrin Aerossol Trigger Cupim Microcapsula Sumithion 20MC Aerossol Wazary (Sumicidin 10 FL) Wazary α(Sumialpha 5FL) Traça Sache Vaporthrin Cartela impregnado Aerossol Pragas de Museu Liquefied CO2 Vaporthrin Gel Aerossol Gokilaht-S Cartela impregnada Sumithrin Vespa & abelha Aerossol ETOC/Gokilaht-S Escorpiões Aerossol OBA Imiprothrin/Gokilaht-S
FORT MULTI-INSETICIDA FORT MULTI-PLUS COM CITRONELA
Formula Base Água Formula Base Água Ativos Ativos - Pynamin Forte - Pynamin Forte - Neo Pynamin Forte - Neo Pynamin Forte -Permethrin -Permethrin
6 FORT AÇÃO TOTAL FORT MATA VOADORES
Formula Base Solvente Formula Base Água Ativos Ativos -Pynamin Forte -ETOC - Neo Pynamin Forte - Pralle -Permethrin -Permethrin
FORT PULGAS e ÁCAROS FORT MATA BARATAS e FORMIGAS
Formula Hidro-alcoólica Formula Base Solvente Ativos Ativos - Sumilarv - Pralle - Sumithrin -Cipermethrin
FORT MATA CUPIM FORT CASA & JARDIM
Formula Base Solvente Formula Hidro-alcoólica Ativo Ativos - Sumicidin - Neo-Pynamin Forte -EBT - Sumithrin
7 FORT VAPORIZADOR LIQUIDO 60N FORT PASTILHA REPELENTE
Ativo Ativo -ETOC -ETOC
Muito obrigado Arigatou gozaimasu
8