University of Michigan hemistry C N E W S L E T T E R

Letter from the Chair

Greetings from Ann Arbor! I write to machines responsible for a wide array of Contents provide an update on Chemistry Depart- important cellular functions. We also ment activities over the past year, and to successfully recruited Julie Biteen (Ph.D.: Letter from the Chair...... 1 thank you all for your continued support Caltech; Post-doc: Stanford) as an assis- New Faculty...... 2 of our program. As most of you know, I tant professor in physical chemistry. Julie am pinch-hitting for Carol Fierke, our cur- will join us in January, 2010, and her re- Faculty News...... 4 rent chair, who is taking a well-deserved search interests are in single molecule and Faculty Profile...... 5 sabbatical break until July 1, 2010. superresolution microscopy, especially as Graduate Program News applied to studying biomolecule motion Despite the severe economic downturn, within live cells. Julie brings with her a Degrees...... 6 especially in the state of Michigan, the prestigious Burroughs Wellcome Fund Ca- Awards...... 7 Department and University continue to reer Award to help facilitate her transition weather the storm reasonable well. While Fajans Award & from post-doc to an independent academic many universities/departments around the Vaughan Symposium...... 8 career. Please read more about these two country have had to implement substantial new faculty within this newsletter. Undergraduate Program News budget cuts (5-10%), the cuts here at U of Degrees...... 9 M have been relatively modest thus far (2% We also had a strong year in promoting for coming year). U of M’s conservative some of our most talented junior faculty. Awards...... 9 financial investment strategy appears to Congratulations are extended to Kristina Summer Programs ...... 9 be paying dividends during these difficult Hakannson (analytical) who was pro- Gifts...... 10 economic times, and this has allowed moted from assistant to associate profes- the Department to continue hiring new sor with tenure, based on her outstanding Alumni News ...... 11 faculty and renovate space to expand our research accomplishments in the field of In Memoriam ...... 13 research and educational missions during high resolution mass spectrometry, and the past year. her excellent record in teaching analyti- Faculty Listing...... 14 cal chemistry. A quartet of outstanding Alumni Reply I am very pleased to tell you that the tenured associate professors, Zhan Chen Form ...... inside back cover Department had a very successful year in (analytical/physical), Adam Matzger (ma- faculty and graduate student recruiting. terials), Hashim Al-Hashimi (biophysical) We just recently welcomed one of larg- and Nils Walter (biophysical) were all est incoming graduate classes ever, with promoted to full professor. Each received 63 talented students entering our Ph.D. glowing praise by outside evaluators for program. With respect to new faculty, 2009 their exceptional research scholarship Brandon Ruotolo (Ph.D.: Texas A&M; and commitment to teaching. As acting Post-doc: Cambridge) joined us in late chair, it was a delight to read the letters The Regents of the University of Michigan: August as assistant professor in the area Julia Donovan Darlow, Laurence B. Deitch, Denise Ilitch, Olivia from external reviewers in all of these of analytical chemistry. His research focus P. Maynard, Andrea Fischer Newman, Andrew C. Richner, S. promotion cases. Many of these letters Martin Taylor, Katherine E. White, Mary Sue Coleman, ex officio. is on biological ion mobility-mass spec- Mary Sue Coleman, president. not only highlighted the outstanding work trometry, especially studying how proteins The University of Michigan is an equal opportunity/affirmative of the individual faculty, but also talked action employer. interact/assemble to form macromolecular

2009 U-M DEPARTMENT OF CHEMISTRY glowingly about the enhanced external NSF REU Site that we administer. As a ment. Our faculty are competing effective- reputation of our Department as a whole true exchange, there were also 12 under- ly for increased funding for research and within the chemistry community. graduate students in chemistry from those infrastructure equipment available from same two schools in China who joined federal agencies as part of the stimulus The Department’s commitment to research groups here in Ann Arbor for initiative (e.g., we recently received word high quality undergraduate education the summer. that NIH will fund ($1.3 M) the purchase continues. Beyond excellent classroom of a new 700 MHz NMR instrument). We instruction, we have been able to provide Some of you may have already heard are continuing to hire the best young chem- more summer research opportunities than that the University recently purchased istry faculty available. Our enrollments ever for our most talented undergraduate the entire former Pfizer research and in chemistry courses remain at an all-time Chemistry and Biochemistry majors. This development site (some 30 buildings high, and we are committed to provide the is in large part due to generous financial and 173 acres of land), and plans are best chemical education possible to both contributions from you, our loyal alums, being formulated to utilize this facility our undergraduate and graduate students. as well as industry. Indeed, this past sum- to greatly enhance the interdisciplinary As always, I hope that we can count on mer more than 27 undergraduates were and translational research activities on your continued generosity to help fund supported by the Department to conduct campus. With > 1,000 fume hoods on various departmental programs in the com- research for 10 weeks within faculty labo- that site, hopefully some of the synthetic ing year (including awards/scholarships/ ratories, along with another 13 students elements of our own chemistry research fellowships for graduate and undergradu- from around the U.S. who took part in our program can ultimately benefit from the ate students, named lectureships, etc..; see Department’s 21st year of an NSF funded acquisition of these facilities. Indeed, it remainder of newsletter for examples!). On REU program (Research Experience for is likely the some chemistry faculty/stu- behalf of all our students and faculty who Undergraduates). In addition, thanks to dents/post-docs will surely be part of new benefit from your kind support, I wish to Prof. Brian Coppola’s efforts, a unique collaborative university research teams in express my sincere thanks, and hope that undergraduate student exchange program the areas of drug discovery, new energy you will stop by to say hello whenever has been initiated between our Department production/storage materials, and other you are back in Ann Arbor. and the chemistry programs at Peking and evolving research areas that are targeted Tsinghua Universities in China. Three of for emphasis at this new North Campus our department’s undergraduate students Research Complex. With all the best, conducted research in China, joining 13 In summary, these are challenging but other chemistry students from around the Mark E. Meyerhoff, Acting Chair also very exciting times for the Depart- US who were supported by an International Philip J. Elving Professor of Chemistry

Department of Chemistry Spotlight: Profiles of New Faculty Newsletter is published once a year by the Department We highlight faculty members who have joined the Department since the last newsletter. of Chemistry at the University of Michigan, Their appointment speaks well for our future. Ann Arbor, MI 48109-1055 Brandon Ruotolo Assistant Professor PhD: Texas A&M University PostDoc: University of Cambridge Printed on Recycled Paper Analytical, Bioanalytical, Biophysical Chemistry, Chemical Biology

Acting Chair: Mark E. Meyerhoff Editor: Arthur J. Ashe, III; Tim Wade Research and Teaching Interests Publication: Agnes Soderbeck Alumni News: Arthur J. Ashe, III, Proteins act as the molecular machinery Robert Kuczkowski of cellular biology, executing numer- ous critical functions in the life cycle of every known organism. To perform their biological function, individual proteins Web Address: associate, often in a transient manner, to form complexes. In some cases, proteins Understanding the function of such protein http://www.umich.edu/~michchem form vast interaction networks capable assemblies is an important scientific goal E-mail: [email protected] of performing intricate cellular tasks. for disciplines ranging from molecular

2 2009 medicine to physical chemistry. However, one of the chief bottle- the composition, size, and topological organization of protein necks in such scientific endeavors is the available technology assemblies from a small amount of sample, in the presence of for determining the structure and architecture of large protein impurities and structural heterogeneity, as a tool for structural complexes. While high-detail structural information can be ob- biology. This focus necessitates research projects that span a wide tained by X-ray diffraction analysis, this experiment requires the range of topics. Some of these projects are focused on classical availability of a sufficient quantity of homogenous material and analytical chemistry, including IM-MS instrument development definition of suitable crystallization parameters. Both conditions (in collaboration with Waters Corporation) and the development are often difficult to meet and the number of atomic structures of computational tools for IM-MS data analysis and 3D model for multi-subunit complexes deposited in structural databases generation (in collaboration with researchers at Lawrence Liv- remains relatively low. Alternative methodologies such as elec- ermore National Laboratory and the University of Cambridge). tron microscopy (EM) and small angle X-ray scattering (SAXS) Other projects focus on the study of protein quaternary structure allow the determination of the surface envelope of complexes stability in the gas-phase, including elucidating the role of small of sufficient dimensions, but interpretation of these data is aided molecules in stabilizing protein structure in the absence of bulk by detailed knowledge of complex composition and is limited to solvent. Still others involve the study of protein self-assembly, homogeneous complexes. Consequently, there is a need to develop aggregation and amyloid formation. Our long-term aim is utilize new approaches capable of defining the subunit stoichiometry, IM-MS data alongside other protein structure determination ap- composition, and shape of heterogeneous macromolecular com- proaches to support the emerging field of integrative structural plexes of biological importance. biology – where many pieces of data derived from disparate techniques are combined to generate a more-complete picture of Our group is primarily focused on developing ion mobility-mass the assembly than was possible with any one tool. spectrometry (IM-MS), an emerging technology that can determine

Julie Biteen superresolution imaging. One Assistant Professor interest in our group is explor- PhD: California Institute of Technology ing the role of protein-nucleic PostDoc: Stanford University acid hyperstructures in a host Biophysical, Materials, and Physical Chemistry, Chemical Biology, Energy of cellular processes, which Science, Optics and Imaging can include chromosome and plasmid segregation, DNA rep- Single-Molecule Fluorescence, Live-Cell Biomedical Imaging, Plasmonics, lication, cell division, motility, Nanophotonics chemo-sensing and signaling, metabolism, cytoskeletal sta- Research and Teaching Interests bilization, and DNA repair. In Superresolution Biomedical Imaging in Live Cells order to treat these and other problems, we seek to adapt The extension of sophisticated nanoscale optoelectronic tools, current methodologies to live techniques and materials to biological systems will enable funda- cell imaging of proteins and nucleic acids, to combine single- mental discoveries, broaden our understanding of key biological molecule fluorescence imaging with plasmon-enhanced emission processes, and assist in the development of novel therapeutics. and quantum dot photophysics, and to improve existing techniques Undertaking such an endeavor at the crossroads of chemistry, to address limitations of spatial and temporal resolution. biology and engineering requires the development of sensitive experimental methods and careful, quantitative analysis proce- Nanophotonics for Solar Energy and Device Physics dures. Research in our group seeks to maximize the impact of The tools of nanophotonics are not limited in their utility to bio- single-molecule fluorescence and nanophotonics by applying logical imaging. In particular, when materials are decreased to a them to investigations of live cells. small size scale, their fundamental optical properties are altered. Superresolution techniques based on single-molecule optical mi- Our group is very interested in the photophysics of small metal croscopy can reach nanometer-scale accuracy. These non-invasive, particles and semiconductor nanocrystals (quantum dots). The non-perturbative methods are ideal for investigating biological fundamental photophysics of such materials can be explored with specimens, and our research is focused on improving these a combination of computational, analytical, and experimental methods and applying them to physiologically relevant problems. tools, and these properties can be applied to solar energy and Because of their small size and lack of subcellular compartments, device physics. the cell biology of bacteria is a particularly difficult challenge for

U-M DEPARTMENT OF CHEMISTRY 3 Faculty News for chemical sensing. His extensive research William R. Roush Junior Faculty Career work has been summarized in over 180 Development Award in 2008. In 2009 she scientific publications. He trained more than received the Theime Chemical Journal Hashim Al-Hashimi received the 2009 20 doctoral and postdoctoral students and Award. She also received a 2009 Office of LSA Excellence in Education Award for his numerous undergraduates in research. Naval Research Young Investigator Award (and grant) and a 3M Non-tenured Faculty outstanding teaching efforts in Chemistry Theodore Goodson III became a Grant. Finally she has been selected to 130, 463 and 480 and a very successful Council for Institutional Cooperation Fel- receive a 2009 Beckman Young Investiga- Freshman Seminar course he developed in low in 2008. Biophysics. In September Hashim and his tor Award. Marc Johnson left the University and is wife Alli celebrated the birth of their first William Pearson, UM faculty member now at Argonne National Laboratory. child Basel. 1984-2003, left his position as Director of Arthur Ashe has written an invited cover Katrin Karbstein and Nicolai Lehnert Research at Berry and Associates in Dexter, review article on aromatic boron hetero- have each been awarded a 2009 NSF Career MI and is now consulting in Chicago. Award. cycles in Organometallics 2009, 28, 4236. James Penner-Hahn has been named He is a consultant for Universal Display Nancy Kerner is a member of the UM the George A. Lindsay Collegiate Professor Corporation. team receiving the 2009 Innovative Use of of Chemistry and Biophysics in LSA. He Mark Banaszak Holl was elected a MERLOT Award. MERLOT is the Multi- became Associate Dean for Budget in LSA Fellow of the American Association for media Educational Resource for Learning in September 2009. and Online Teaching. She received the 2009 the Advancement of Science (AAAS) in Ayyalulusamy (Rams) Ramamoorthy’s Chemistry Distinguished Faculty Teaching 2009. He was honored for his distinguished studies of islet amyloid polypeptides related Award. She was a keynote speaker at the contributions bridging disciplinary boundar- to type-2 diabetes have been receiving wide MACTLAC meeting at Hope College. ies in studies of chemical and biochemical publicity. Rams was a Distinguished Visit- processes at the nanoscale. In September he Robert Kennedy received a NIBB ing Professor at the Max Planck Institute at began a three year term as Associate Vice MERIT award from NIH in 2008. This Mainz, Germany in summer, 2009. He is President for Research in natural science year he is the recipient of a Rackham Distin- also the recipient of a 2009 JSPS (Japanese and engineering at UM. guished Faculty Achievement Award (UM). Society for the Promotion of Science) Fel- Brian Coppola has been appointed Asso- In 2010 he will become the Associate Editor lowship. He coauthored an invited review ciate Director of the UM-Peking University of Analytical Chemistry. article with Neil Marsh, “Fluorine–a new element in the design of membrane-active Joint Institute. Raoul Kopelman delivered the Iddles peptides,” in Molecular Biosystems 2009, Chemistry Lecture at the University of Kate Carol received a 2008 American 5, 1143. Heart Association Scientist Development New Hampshire, a lecture at the Fos- ter Chemistry Colloquium at SUNY Melanie Sanford was featured in the Award. She recently published a notable th paper in ACS Chem. Biol. 2009, 4, 783. The Buffalo and the 29 Pittcom Lectures at November 2008 issue of Popular Science paper describes a technique for mapping of the University of Pittsburgh all in 2009. In as one of the “Brilliant Ten.” Each year where reactive oxygen species interact with March he appeared before a Congressional the magazine picks the ten most innovative cell proteins. subcommittee at a briefing on “Break- young US-based scientists and features them throughs in Medicine through Medical and in a special issue. In 2009 Melanie received James Coward, who retired last year, Biological Engineering.” His testimony the BASF Catalysis Award. She recently has moved to the Albany, NY area. He was was a part of the successful effort to add joined the Editorial Advisory Board for honored this year as a 50 year member of stimulus funds to the NIH budget. JACS. This year she was a plenary speaker the American Chemical Society. at the 41st National Organic Symposium held Robert L. Kuczkowski returned to NSF Boulder, CO and a featured speaker at the Anthony (Rick) Francis has become for a year as Program Director for Chemical 2009 Welch Conference on “Advances in Associate Dean for Special Projects in LSA Research Instrumentation and Facilities. He Synthetic Chemistry” in Houston, TX. (2009-2011). was honored this year as a 50 year member John L. Gland retired from active status of the American Chemical Society. David Sherman was elected a Fellow of the American Association for the Advance- in May and was appointed Professor Emeri- Daniel Longone served as curator of an ment of Science (AAAS) for 2009. tus. John came to the University in 1988 from exhibit at the William Clemens Library in General Motors Research Laboratory and May 2009. It was entitled, “500 Years of Nils G. Walter is an Associate Editor of Exxon Research and Engineering Company American Grapes and Wines: A Remark- the Wiley journal Biopolymers. He is also Corporate Research laboratory. His research able Journey.” co-editing a book on Non-protein coding interests included molecular mechanisms of RNAs for the Springer series in Biophys- Adam Matzger’s research on hydrogen hydrogenation reactions on metal surfaces, ics. He is a guest editor for two volumes on storage techniques was featured on an April in-situ X-ray methods for characterizing the single molecule techniques and an issue RNA 2009 program on the Discovery Channel. bonding and reactivity of adsorbed species, dynamics for Methods in Enzymology. mechanisms of olefin partial oxidation on Anne McNeil received the Elizabeth silver based catalysts, and tin film materials Caroline Crosby Research Award and the

4 2009 Faculty Profile Vince has also developed a research program using de novo protein design to explore heavy metal toxicity, metal ion homeo- stasis and metalloenzymology. His work has been important for Vincent L. Pecoraro presented his inaugural lecture as the John understanding the biological chemistry of Hg(II), Pb(II), Cd(II) T. Groves Collegiate Professor of Chemistry on April 14, 2009. and As(III). Furthermore, his group recently prepared the first Collegiate Chairs honor the recipient and a former distinguished designed metalloenzyme containing both Hg(II) and Zn(II). These faculty member of LSA for whom the chair is named. Professor studies directly evolved from his early work that was honored in John T. Groves was a member of our Department form 1969 to 1986 by the first G.D. Searle Biomedical Scholar prize awarded 1985 and now holds the Hugh Stott Chair of Chemistry at Princ- in the College of Literature, Science and Arts at the University eton. Jay returned to Michigan to help Vince celebrate and also of Michigan. Over the past 25 years, Vince’s over 200 publica- presented a delightful lecture on his current research. tions have been cited nearly 9,000 times. In addition to being a leading research scientist, Vince has served in various roles on The Department congratulates Professor Pecoraro for his numerous committees and boards from the chemistry department prestigious accomplishments and has chosen to highlight him to international organizations. He presently is the Director of the in this newsletter. Vince Pecoraro, although born just outside of Michigan Chemistry Biology Interface Training Program, has Manhattan, was raised as a “Valley Boy” in Southern California. served on the Advisory Board of The American Chemical Society’s He received a B.S. in chemistry in just 3 years from UCLA and Petroleum Research Fund, has been a member of numerous study then moved to the University of California, Berkeley where sections and review panels for NIH and NSF and has served as a he completed Ph.D. studies on the chemistry of bacterial and reviewer of scientific programs throughout Europe. Vince is also human iron metabolism with Professor Kenneth N. Raymond. a dedicated educator. He has chaired over 20 Ph.D. committees Subsequently, Vince returned to the biochemical arena by joining and has sponsored nearly 100 undergraduate researchers during Professor W.W. Cleland’s enzymology group at the University his career. He has taught effectively across the full range of di- of Wisconsin, Madison as an NIH Postdoctoral Fellow. In an ef- dactic and laboratory courses ranging from general chemistry to fort to nucleate a more biologically oriented group at Michigan, advanced graduate topics. We know that Vince feels particularly Vince was hired as an Assistant Professor in 1984 with the intent blessed to have worked with such a wonderful cohort of postdocs, of exploring the role of metals in biology. Since this time, Vince graduate and undergraduate students during his career. has rocketed through the professorial ranks while establishing himself as one of the world’s leading bioinorganic chemists. His With all of these accomplishments, it seems hard to believe achievements have been recognized by numerous awards, plenary that Vince manages a rewarding personal life. He has been happily lectureships and his appointment as Associate Editor for Inorganic married to Professor Peggy Carver (UM College of Pharmacy) Chemistry over fifteen years ago. for 17 years, whom he met on a blind date arranged by former UM Professor Will Pearson. Both Vince and Peggy love traveling Vince’s early work focused on unraveling the structure and (Vince is in such demand as a speaker that years ago, some of clarifying the chemical mechanism of the reactive center of the his Michigan colleagues annointed him the Northwest Airlines Oxygen Evolving Complex found in algal and plant Photosystem Professor of Chemistry) and the many great friendships they II. His work has been highly collaborative, often publishing with have developed around the world as a result of their scientific Michigan colleagues Jim Penner-Hahn and Charlie Yocum as well pursuits. Both are foodies, enjoying good food, wine and con- as the top research groups in this field around the world. These versation wherever it may be found. Vince also claims to have a studies initially were focused on one of the great questions in deep affection for art (his father is a superb painter), history and biology: how plants, using manganese and calcium, split water languages. In an ideal world, they would split their time between to produce dioxygen, protons and electrons. The work has gar- Ann Arbor, Paris and Kauai. nered even more attention as our nation focuses on alternative energy sources which may require advanced catalysts for these transformations. In addition to these studies, Vince has used synthetic coordination complexes to elucidate the mechanism of non-heme containing Vanadium Haloperoxidases, a unique enzyme class which uses high valent vanadium and hydrogen peroxide to halogenate or alternative oxidize organic substrates. In 1989, Vince ventured into supramolecular chemistry when his group identified a new class of molecules now called metal- lacrowns. These structures, which were among the very first metallamacrocycles described, have amazingly lovely structures and interesting physical properties. Metallacrowns have now been made into molecular magnets, soft solid hosts for non-linear opti- cal materials and sensors. His group is now hoping to combine and exploit these properties, allowing them to make exciting, new complex molecular systems. Dean T. McDonald, Vincent Pecoraro, John Groves at the lecture on April 14, 2009

U-M DEPARTMENT OF CHEMISTRY 5 Graduate Program News

Graduate Degrees - Masters & Ph.D August 2008, December 2008, May 2009 & August 2009

Doctorates Matthew Schulmerich Dr. Michael Morris Subsurface and Transcutaneous Raman Spectroscopy, Imaging, and Sara Buhrlage Dr. Anna Mapp Tomography Small Molecule Transcriptional Activation Domains Kristin Smith-Koutmous Dr. Carol Fierke Jinhui Chen Dr. Arthur Ashe, III Investigation of the RNA-Protein Interactions in Bacterial Ribonu- Boron Heterocycles: from Aromaticity to Electronic Materials clease P (RNase P) John Dishinger Dr. Robert Kennedy Xiaoyan Sun Dr. Hashim Al-Hashimi Parallel Separations on Microfluidic Chips for High Throughput Investigating Kissing to Duplex Dimer Transition Mechanism of Monitoring of Insulin Secretion from Single Islets of Langerhans HIV-1 SL1 by NMR Trisha Duffey Dr. Edwin Vedejs Thomas Sundberg Dr. Gary Glick Chiral Nucleophilic Catalysts: Applications in the Synthesis of 3, Elucidation of Anti-Proliferative and Pro-Apoptotic Signaling Induced 3-Disubstituted Oxindoles and Parallel Kinetic Resolution by the Immunomodulatory Benzodiazepine Bz-423 Cory Fix Dr. Mark Meyerhoff Rebecca Veeneman Dr. Edward Zellers Comprehensive Multidimensional Gas Chromatography and Modula- Design and Characterization of a Multi-Vapor Preconcentrator for a tor Development for Portable Instrumentation Micro-Scale Gas Chromatograph Andrea Geyer Dr. Marc Johnson Salena Whitfield Dr. Melanie Sanford Development and Investigation of NW(OR)3, NMo(OR)3, and New Oxidation Reactions of Palladium and Platinum: Synthetic and Mo2(OR)6 Complexes for Triple-Bond Metathesis Mechanistic Investigations Alexandar Hansen Dr. Hashim Al-Hashimi Li Yi Dr. Ronald Woodard Development of 13C Nuclear Magnetic Resonance Methods for Studies of 3-Deoxy-D-manno-Octulosonate 8-Phosphate Phosphatase: Studying the Structural Dynamics of Nucleic Acids in Solution Mechanistic Insights and a Gene Fusion Example Ananda Herath Mudiyansela Dr. John Montgomery Development of Nickel-Catalyzed Cycloaddition and Coupling Reac- tions Masters Gwendolyn Anderson Jonas Locke Kami Hull Dr. Melanie Sanford Jameson Bothe Matthew Lorenz Palladium-Catalyzed Oxidative Functionalization of C-H Bonds Marchello Cavitt Kaysia Ludford Tse-An Chen Anastasia Kalli Dr. Kristina Hakansson Eric Majchrzak Travis Clark Anna Merkle Protein and Lantibiotic Sequencing by Gas-Phase Dissociation Involv- Billy Clifford Nunn Lang Ming ing Vibrational Excitation and Ion-Electron Reactions Noah Gardner Cheryl Moy Deidra Gerlach Dipannita Kalyani Dr. Melanie Sanford Sharon Neufeldt Lauren Goodrich Joshua Neukom Site Selectivity in Palladium-Catalyzed Oxidative Functionalization Xiamou Guan Corrine Sulok Reactions Amanda Hickman Benjamin Thompson Charalampos Kalyvas Charalampos Kalyvas Dr. Dimitri Coucouvanis Meng Wang Austin Kizzie Amanda Ward Synthesis of M/Fe/S Clusters Relevant to Biological Systems and Asako Kubota Jenna Welby Minerals Erica Lanni Crystal Young Stephanie Le Clair Evelyn Kim Dr. David Lubman Development and Application of Proteomics in Ovarian Adenocar- cinomas Using Multi-Dimension Separation, Microarray and Mass Spectrometry Chinmay Majmudar Dr. Anna Mapp Mechanistic Investigations of Transcriptional Activator Function for the Design of Synthetic Replacements Jingjie Mo Dr. Kristina Hakansson Characterization of Nucleic Acid Non-Covalent Interactions by Fou- rier Transform Ion Cyclotron Resonance Tandem Mass Spectrometry and Gas-Phase Hydrogen/Deuterium Exchange Shaelah Reidy Drs. Mark Meyerhoff & Franklin Dorman High-Performance Micro-Fabricated Gas Chromatography Columns for Complex Mixture Analysis Curtis Schneider Dr. Vincent Pecoraro Development of Asymmetric Sulfoxidation Catalysts Based on Fun- tional Models for Vanadium Dependent Haloperoxidases Annual Graduate Awards Icecream Social on June 25, 2009

6 2009 Graduate Awards Rackham International Student Fellowship Kaysia Ludford - K. Carroll Rackham Merit Fellowships and Science Awards Departmental Awards Maximillian Bailor - Al-Hashimi Tanya Breault - Bartlett American Chemical Society Outstanding Graduate Student Alana Canfield - Brooks Award for Research and Teaching Anette Casiano - Al-Hashimi Marchello Cavitt - Ramamoorthy Anne Vázquez - Chen Deidra Gerlach - Coucouvanis Robert & Carolyn Buzzard Graduate Chemistry Student Shana Santos - Soellner Leadership Award Thu Truong - K. Carroll Kara Stowers - Sanford Rackham One-Term Dissertation Fellowship Alumni Fund for Outstanding Graduate Student Research Anastasia Kalli - Hakansson Meng Guo - Goodson Rackham Predoctoral Fellowship Florence Fenwick Outstanding Graduate Student Instructor Alexander Hansen - Al-Hashimi Award Biyun Wu - Meyerhoff Laura Zimmerman - Meyerhoff Sandia National Laboratories Fellowship Milton Tamres Outstanding Teaching Award Cory Fix - Meyerhoff Lauren Goodrich - Lehnert University of Michigan Substance Abuse Research Center Interdisciplinary Program Departmental Fellowships Maura Perry - Kennedy Vaughan Symposium Awards George Ashworth Analytical Chemistry Fellowship Oral Presentation Awards: Wen Zhou - Hakansson Dow Chemical Foundation Spring Fellowship - Matt Remy - Sanford Robert W. Parry Award Travel Awards - Jing Chen - McNeil & Anne Vasquez - Chen Timothy Berto - Lehnert Poster Session Travel Awards: Devayani Bhave - Carroll Peter A.S. Smith Fellowship Zachary Buchan - Montgomery Ajdin Kavara - Banaszak Holl Daniel Flynn - Goodson Margaret & Herman Sokol Graduate Summer Research Amanda Hickman - Sanford Fellowship Sun Kyu Kim - Zellers Tom Lyons - Sanford Jing Chen - McNeil Anna Merkle - Lehnert Chemistry Excellence in Research Fellowship Cheryl Moy - McNeil Carlos Baiz - Kubarych Ravi Nanga - Ramamoorthy Jing Chen - McNeil Candice Paulsen - Carroll Jiyoung (Annie) Hong - K. Carroll Joy M. Racowski - Sanford Christopher Taylor - Mapp Jennifer Schnobrich - Matzger Meng Wang - Kennedy Gustavo Serrano - Zellers Kazutoshi Yamamoto - Ramamoorthy Ronald Soong - Ramamoorthy Crystal Young - Karbstein Grant Sormunen - Montgomery Meng Wang - Kennedy Chemistry Research Achievement Fellowship Sung-Hei Yau - Goodson Ryan Baxter - Montgomery Crystal Young - Karbstein Katie Cychosz - Matzger Thomas Lyons - Sanford Training Grants Chemistry Research Excellence Travel Award Alexander Johnson-Buck - Walter Cellular Biotechnology Training Program (CBTP) Kara Stowers - Sanford Kathryn Dooley - Morris Chemistry-Biology Interface Training Program (CBI) Non-Departmental Awards Matthew Leathen - Wolfe Eli Lilly Fellowship Graduate Assistance in the Area of National Need (GAANN) Neil Hershey - Kennedy Ryan Baxter - Montgomery Jameson Bothe - Al-Hashimi Graham Environmental Sustainability Institute Fellowship Joseph Jankolovits - Pecoraro Katie Cychosz - Matzger Alan Kiste - Coppola National Science Foundation Fellowship Allison Knauff - Montgomery Anne Labut - Karbstein Marchello Cavitt - Ramamoorthy Rebecca Lahti - Banaszak Holl Brannon Gary - Sanford Daniel Miller - Vedejs Amanda Hickman - Sanford Cheryl Moy - McNeil Erica Lanni - McNeil Anne Vázquez - Chen Novartis Graduate Fellowship in Organic Chemistry Amberlyn Wands - Mapp Kara Stowers - Sanford Microfluidics in Biomedical Sciences Training Program Pfizer Graduate Fellowship (MBSTP) Meng Wang - Kennedy Colin Jennings - Kennedy Rackham Distinguished Dissertation Award Molecular Biophysics Training Program (MBTP) Matthew Schulmerich - Morris Alexander Johnson-Buck - Walter Stephanie Le Clair - Ramamoorthy/Chen

U-M DEPARTMENT OF CHEMISTRY 7 Pharmacological Sciences & Biorelated Chemistry Training The Victor C. Vaughan Symposium Program (PSTP) Grant Sormunen - Montgomery The Vaughan Symposium (http://umich.edu/vvaughan/) was held Regenerative Sciences Training Grant in Chemistry Department on August 7, 2009. The symposium is Kathryn Dooley - Morris named in honor of Victor C. Vaughan (1851-1921) who was one John-David McElderry - Morris of the first students to graduate from the University with a PhD Training Program in Reproductive Endocrinology (RSP) in Chemistry (1876). Dr. Vaughan subsequently earned an MD Gwendolyn Anderson - Kennedy from Michigan in 1878 and went on to a distinguished career in medicine. He served as Dean of the Medical School 1891-1921 and president of the AMA (1914-5). The Vaughan Symposium was designed by and is run by Michigan Chemistry graduate students. It serves as a venue in which to share exciting research taking place within the Depart- ment. Originally named PECRUM, the first symposium was held in 2003. Through participants presenting their work to the Department as a whole, students foster collaborations, inspire new avenues of research, and nurture a growing sense of community within the Department. The symposium has become an annual tradition within the Department of Chemistry. Kasimir Fajans Dissertation Award This year’s symposium was organized and run by a committee The Kasimir Fajans Award for the most outstanding doctoral dis- of eight senior graduate students and chaired by Nicholas Ball. sertation in Chemistry is the Department’s most venerable award. It started and finished with two excellent plenary lectures on The award was established in 1956 by friends and colleagues of polymer chemistry by Dr. James C. Stevens of Dow Chemical Professor Kasimir Fajans (1887-1975) on the occasion of his Company and Professor Geoffrey Coates of Cornell University. retirement as an active faculty member and in recognition of his In between there were six 25 minute talks by graduate students. distinguished contributions to science. The Kasimir Fajans Award Student research posters (92) were presented in morning and consists of an honorarium and an invitation to deliver a scientific afternoon sessions. All registrants (>200) received a free lunch lecture to the Department. The Awardees’ names are on perma- and a symposium t-shirt. nent display on a bronze plaque in the main conference room of The organizing committee selected the oral presentation, the Department. These awards are selected by a special faculty “Developing Palladium-Catalyzed Oxidative Oligomerization of committee. There have been a total of 26 prior awards. Methane: How Mechanistic Study Lead to New Proposed Cata- For the years 2006-7 there were 79 eligible candidates, a record lytic Cycle,” by Matthew Remy (a Sanford student) to receive the number! Because of this large number and the high quality of award for the outstanding oral presentation. The award consists the dissertations, the committee chose to make two awards. The of a fellowship for the spring term 2010. There were two other co-awardees are Dr. Xiaoyun Chen and Dr. Katherine Plass. awards for oral presentations and 18 for excellent posters. The awardees are listed in Graduate Student Award Section of this Dr. Chen’s thesis is titled, “Investigating Biointerfaces using newsletter. These awards of $500 each are to be used to attend a Sum Frequency Generation Vibrational Spectroscopy.” His scientific meeting. We are grateful to the Dow Chemical Company thesis advisor was Professor Zhan Chen (no relation) and he is for their generous support of these awards. presently employed by the Dow Chemical Company in Midland, MI. On September 10 he delivered his lecture, titled, “Industrial Applications of Vibrational Spectroscopy.” Dr. Plass’ thesis is en- titled, “Structure, Symme- try, and Stability of Two- Dimensional Crystals.” Her thesis advisor was Professor Adam Matzger. She is currently an Assis- tant Professor of Chemistry at Franklin and Marshall College in Lancaster, PA. Her lecture is scheduled for March 17, 2010.

Xiaoyun Chen and Zhan Chen A Graduate Student poster presentation at the Vaughan Symposium

8 2009 Samuel Eaton Undergraduate Program News Katherine Gibney Tyler Greer Undergraduate Degrees Alica Guzman Zhe Han August 2008, December 2008, May 2009 & August 2009 Qiyang Jin Adam Justusson Hugh Klavon Biochemistry Mallory Johnson Pradeep Poonnen Nicola Kuhlmann Baccalaureates Jesse Jun Andrew Rasmussen Corey Lager Ali Artail Daniel Kechele Jason Riley Thomas Lauzon II Jared Babcock Jeeyong Kim Kolby Roberts Tracy Lent Thomas Bander James Kornacki Lindsay Saunders Alex Martin Kyle Beckwith Sora Lee Mallory Sherwood Emily Mirkin Jacob Begres Schuyler Lee Candice Smith Yuki Murata Kristy Bojazi Brian Lin Jeri Spriet Andrew Parth Nicholas Boswell Thomas Lin Alexis Steinmetz Cherilyn Pascoe Ashley Budd Brian Magnuson Patricia Szmal Katie Preston Jennifer Buehler Stacy Malaker Carmen Tugulan Andrew Rasmussen Gina Buiocchi Katherine Manno Kevin Vlach Lahdan Refahiyat Maxim Burgman Kalev Maricq Anmin Wang Max Reichwage Jason Chen Colleen Mayhew Jeffrey Yackley Michael Roberto Paul Cipriani Admir Mesanovic Daina Zeng Rebecca Siegel Garrett Coyan Zachary Miller Jeffrey Simon Esmaeel Dadashzadeh Roshan Najafi Joel Skaistis Anthony Emanuele Kari Neier Chemistry Baccalaureates Bryan Tebeau Ikenna Nwamba Nicholas Urban Charles Fehl Thomas Bratton Jeffrey Osborne Jason Witek Kevin Frank Sarah Breed Kiriaki Panagopoulos Miguel Wong Robert Gildersleeve Lyndsey Brown Joseph Pawlowski Jason Wu Charles Gray Maxim Burgman Hai Pham David Yancey Ye Hu Brandon Chan

Undergraduate Awards

CRC Outstanding Freshman Achievement Award Honors College Vanko Award Justin Priest Esmaeel Dadashzadeh Alpha Chi Sigma Outstanding 1st Year Student Award Huron Valley Section-Outstanding Student Leadership Apurba Chakrabarti Award Alumni 1st year Achievement Awards Matthew Stier Juan Andino• Melissa Gildenberg • Aaron Goodman • Rachna Goswami • Seyhan N. Ege—WISE Award Nikhil Iyer • David Springstead • Matthew Stier Tracy Lent Alumni Outstanding Awards American Chemical Society Analytical Chemistry Award 2nd year Student Jonathan Mahlow, Kaitlin McLouglin Azhar Carim 3rd year Student Esmaeel Dadashzadeh, Jesse Jun Merck Index Award to Outstanding Seniors Senior Student Paul Baciu, Jennifer Raymond Samuel Eaton • Charles Fehl • Alica Guzman • James Kornacki • Andrew Summer Research Awards Rasmussen American Institute of Chemists Award 2009 Seyhan Ege Undergraduate Research Fellowship Anthony Emanuele • Jeffrey Simon Award Azhar Carim • Melissa Hoffman • Michael Holland • Jesse Song • Benjamin Throesch 2009 James E. Harris Scholarship Award Vivek Behera • Umair Daimee • Hang (Helen) Shi • Brittany Worley 2009 Novartis Undergraduate Research Fellowship Award: Undergraduate Programs Rebecca Chota • Tamar Shrikian 2009 PPG Undergraduate Award Research Experience for Undergraduates (REU) Ryan Bradstreet • Kaitlin McLoughlin • Saman Mirkazemi 2009 William G. Smeaton Memorial Award The department once again hosted a successful NSF-funded REU Kenneth Chen • Jennifer Cui program, as it has continuously since 1989. A group of students 2009 Margaret and Herman Sokol Endowment Award with exceptionally diverse backgrounds spent 10 weeks on campus Christina Galloway • Melanie Sabbagh • Chen Wang • Yefim Zaltsman doing full time research in one of our groups. The program also provides for weekly sessions on understanding different research Alumni Outstanding Awards: Second Year —Michael Kheir • Christina Suh • Grace Zhu options in the department, an introduction to the graduate school Third Year —Sarah Garnai • Christina Galloway • Christine Morrison application and funding process, in addition to field trips to local Senior —Lindsay Saunders industrial settings. This list includes students from the REU Site

U-M DEPARTMENT OF CHEMISTRY 9 and those on REU Supplements. Professors Coppola and Sanford Evolutionary Biology, and Molecular, Cellular & Development as the co-directors of the domestic REU Site. Biology. Pfizer has increased its commitment to include students from the biological sciences. At the end of the summer, all of our students participate in a regional presentation and poster session that rotates between the Because the other world-class university in Beijing, Tsinghua REU programs at U-M, Notre Dame, and Hope College. This University, is located right across the street from Peking Univer- year’s symposium, which had over 175 student posters, was held sity, we pursued a successful expansion of the summer program at Notre Dame. to include both schools. The students, regardless of which direction they travel, return PKU home with a strong sense of confidence and comfort about their potential to participate and collaborate in an international set- International REU and exchange program with China ting, and with having formed a strong network of professors and http://umich.edu/~michchem/UMPKU students in their host country. In 2007, the department piloted a summer undergraduate research One important feature of our international REU program is the exchange in chemistry between U-M and Peking University. existence of the UM/PKU Joint Institute, which provides us with Three UM students went to PKU for a 10-week program (2 complete staffing and communications support for getting work weeks orientation, 8 weeks of full time research) and four PKU done in Beijing, whether we are present or not. Professor Brian students spent 8 weeks in the labs in Ann Arbor. Coppola, who is the Associate Director of the Joint Institute, and In 2008, we received 10 positions per year, for 3 years, from Professor Jim Penner-Hahn, are the co-directors of the Interna- the National Science Foundation for the US-to-China direction tional REU Site. (recruitment from around the US required, although up to 3 of these 10 could be used for UM students). A critical feature of our proposal was putting up an additional 3 positions per year of our own, exclusively for U-M students. Also in 2008, we assisted our colleagues in China to help en- sure a true exchange program. Currently, there are no structured sources of funds for supporting Chinese undergraduates to do work abroad. Based on the successful proposal to NSF, Pfizer Global R&D in Shanghai supported six 50% positions, with the matching funds coming mainly for Peking University along with a smaller contribution from U-M faculty mentors. In 2009, we expanded the exchange program to include the Bio- logical and Life Sciences. U-M students (and faculty hosts for the PKU students) were be drawn from Chemistry, Ecology & PKU students in a light moment

Jen-Jen Liu Mao Gifts Timothy F. Merkel P & G Fund* Contributions from private and corporate donors received Rosemarie M. Potts James and Tonia Thirtle from July 1, 2008 – June 30, 2009 (* Indicates corporate matching funds.) Chemistry Dept Library Dr. and Mrs. Richard J. Bard John M. Costantino, D.O. Chemistry Alumni Fund George B. Lowrie III Deloitte Foundation* Intel Charitable Trust* BASF Corporation* Dawn A. Merritt Stephen L. Gaudioso Dr. and Mrs. Antone L. Lott Mrs. Diane H. Burley Annabel and John Muenter Janet C. Haartz, Ph.D. Edwin and Roberta Przybylowicz Cargill Foundation* Randolph K. Otto, M.D. Xerox Corporation U.S.A.* Gary and Sally L. Chipman William A. Pavelich Edward B. Sanders, Ph.D. Steven A. Clarke Pfizer Foundation* Schering-Plough Foundation, Inc.* Chemistry Graduate Fellowships American Chemical Society Dominion Foundation* Wayne and Carol Pletcher Chemistry Dept Fund Klaus and Joel L. Schmiegel Amgen Foundation David and Jacqueline Duchane Dr. and Mrs. David W. Badger Suzanne and Erich Schulz Bristol-Myers Squibb Company David and Priscilla A. Ebdon Dr. and Mrs. Thomas P. Caughey Elfreda and Joseph Shepard Dow Chemical Company Foundation Gerald Fong and Day-Lih Tung Dan G. Chapel Hilary E. and Kristi D. Snell Steven R. Jordan David J. Hart CIBA Specialty Chemicals Foundation Gregg S. Spitler Lisa A. Lanning Gordon Parrington and Mary Ellen Inc.* Graham D. Stewart Eli Lilly & Company Foundation Heyde Renee I. Cribbins 3M Foundation* Agnes Kim-Meade and Eric Meade Kurt and Kathy Hillig Colleen and Lee DeKay Paul F. Zittel Mark and Marsha Meyerhoff Roland F. Hirsch J.M. Goldberg & B.J. Burroughs Novartis Institute for BioMedical Walter M. Holloway, Jr. Mr. and Mrs. Thomas W. Gougeon Bachmann Memorial Lecture Research, Inc. James and Patricia Huntzicker Jeffrey Hsi and Amy Wagenfeld Robert A. Gregg Pfizer International Inc. Dominick and Carol Ann Labianca Thomas M. Jackson Schering-Plough Foundation, Inc*. Eli Lilly & Company Foundation* Chairman’s Discretionary Fund Harold L. Kohn, Ph.D. Dr. and Mrs. William D. Wright

10 2009 Chemistry Special Scholarships J.R. Hopkins John and Christine Wright David W. Stewart Memorial Irving and Frances Adler Dr. and Mrs. Norman P. Jensen Dorothy T. Wu Fund John F. Mahaney Trust Air Products & Chemicals, Inc. Chemistry, Presidential Chal- David W. Stewart Estate Nancy and Roger Jestel Robert and Sylvia Jones lenge for Grad Support Seyhan N. Ege Junior Faculty Lubrizol Foundation James M. Julian II Amgen Foundation* Novartis Institute for BioMedical Karl J. Kossen Award BASF Corporation* Research, Inc. Amanda R. Kupstas Marjorie L. and Donald J. Carter William F. Bradford Pfizer, Incorporated Dr. and Mrs. Robert A. Landowne Seyhan N. Ege Estate John and Rosemary Callahan PPG Industries Foundation John and Mary Larsen Michael Chaykovsky James E. Harris Scholarship Jack Sweet Ginny Shen Lin Fund in Chemistry Gordon Lockyer Dow Corning Corporation* Susan and Joel Wolfe Marian E. Harris Timothy E. Machonkin Richard and Judith Doyle Chemistry Strategic Fund Edward D. North Vincent P. and Roxanne M. Drnevich Milton Tamres Teaching Award August J. Altese Paul J. Nowak Ronald Rex Dueltgen Marjorie L. and Donald J. Carter Steven and Jacqueline Boskovich George M. Olds David and Shirley Emerson Robert Parry Scholarship Fund Dr. and Mrs. James L. Brewbaker Randolph K. Otto, M.D. Helen and P.L. Fan Earl R. Alton, Jr. William A. Bush, D.O. Irene C. Piscopo Carol A. Fierke Marvin and Kathryn Andersen Campbell Soup Foundation* Kimberly and Daniel Pittel Thomas and Denise Gallagher Dr. and Mrs. Thomas J. Giordano Elna M. Clevenger John and Susan Powers Howard L. Garrett Charles and Leona Heitsch Renee I. Cribbins Christina and Mark Rearnick Shirley M. Hoenigman Karen and Joseph Morse Colleen and Lee DeKay Joanne and Jerry Robertson Dr. and Mrs. Jerome P. Horwitz Robert T. & Bonnie P. Paine Edward L. DeMeritt Samuel W. Root, M.D. Thomas and Carol Houser Nancy Schary Dr. and Mrs. Russell R. Dickerson Dr. and Mrs. Thomas Rosseel Kathleen and William Jackson Charles S. Weinert Christopher Espinosa Charles A. Roth Phyllis E. Karseboom Dean F. Fleury Walter E. F. Rupprecht Richard Paul Kosinski Peter A.S. Smith Fellowship Kathryn and Kevin Fox Dr. Richard N. Loeppky Helen S. Schaefer Roy and Judith Pointer Susan E. Forest Richard M. Scribner Dr. and Mrs. Bernard Manning Bernam and Shirley S. Fraley Mary Ellen Sheridan Jen-Jen Liu Mao Robert & Carolyn Buzzard Grad Dr. and Mrs. Stewart E. Gloyer David L. Siroky Dr. and Mrs. John J. McBride Chem Stud Leadership Juliana Boerio-Goates and Steven Michael P. Skinner Merck Company Foundation* Robert and Carolyn Buzzard Goates Berj K. Parseghian Kristi D. and Hilary E. Snell Robert Kuczkowski Faculty Bruce and Laura Goethe Robert M. Stewart Trust Pfizer Foundation* Joung and Mark Goulet James Pivnichny and Joan D. Vanpelt Award Susan Holbrook Taylor Robert and Ann Kuczkowski Philip L. Gravel Harlene J. Turner Donna L. Prince Tony and Celeste Greco Henry A. Tuttle Morley and Maureen Russell Willard Memorial Lecture Fund and Mrs. David Greenblatt Edwin Vedejs Terene M. and John Scibelli Graham D. Stewart Bruce M. Greenfield, M.D. Paul Denzle Walker 3M Foundation* David J. Hart Edward and Leigh Washabaugh Robert C. Tripp * Indicates corporate matching fund Milton and Dorothy Heller Barbara J. Widman Howard H. Un Douglas A. Whittington

Alumni News Research at the Metropolitan Museum of Art (NY), since 2006. She works closely E-Mail your news: [email protected] with the paintings and Paper Conserva- Update your contact information: http://www.umich.edu/~michchem/alumni/ tion Departments and has expertise in the analysis of paint and coating composition, If errors or misstatements are noted in any of the following items, the Editors of the stratigraphy and technology. She is accom- Newsletter would appreciate such being called to their attention. Mistakes can and do, plished in the analysis of both traditional inadvertently, creep in. Corrections can easily be inserted in the next edition. and non-traditional artist’s materials as well as polymeric materials. Her fields she moved to New Jersey where she is a Sultan T. Abu-Orabi (PhD 1982, Arthur of interest include the application of mass Senior Research Biochemist with Merck Ashe) became the President of Yarmouk spectrometric and immunological tech- Research Laboratories in Rahway. University (Irbid, Jordan) in March 2009. niques to the study of organic polymers. Yarmouk is the oldest university in Jordan. Matthew Alexander (PhD 2003, James Her prior training included a Fellowship Dr. Abu-Orabi had previously served as the Coward) was a postdoctoral with Professor at Smithsonian Museum Conservation Presidents of Tafila Technical University Michael D. Burkart at University of Cali- Institute, a Diploma in Conservation of (2005-9) and Irbid National University fornia at San Diego. Since 2007 has been Easel Painting from the Courtauld Institute (2001-5). a Senior Research Scientist in Medicial of Art (London) and a Mellon Fellowship Jessica Pankuck Alexander (PhD 2003, Chemistry at TetraLogic Pharmaceuticals at the Balboa Art Conservation Center, San James Coward) was a postdoctoral with in Malvern, PA. He and Jessica live in Diego (CA). Cream Ridge, NJ. Professor Benjamin Cravatt of the Scripps Eric Baker (Postdoctoral 1994, Raoul Ko- Research Institute in La Jolla, CA follow- Julie Arslanoglu (BS 1987, MS Penn. pelman) has become a Chaired Professor at ing graduation from Michigan. In 2004 State U.) has been an Associate Research the University of Western Australia. she married Matthew Alexander. In 2007 Scientist in the Department of Scientific

U-M DEPARTMENT OF CHEMISTRY 11 Susan Barker (PhD 1999, Raoul Kopel- Tara Conser Hagena (PhD 2008, James years. He worked in the areas of monomer man) now works for System Planning Coward) is an Instructor in the Depart- and polymer synthesis for applications in Corporation. She lives in Charlottesville, ment of Chemistry at Western Washington engineering plastics. He retired in 2001 VA and works part time so she has enough University in Bellingham. and is pursuing another passion of his: time for her children Rachel (6) and Caleb Matthew C. T. Hartman (PhD 2002, baseball research. In 2006 his first book was (4). James Coward) is an Assistant Professor published by McFarland, “ Leadoff Batters of Major League Baseball – Complete Heather (Crocker) Clark (BS 1994, PhD of Chemistry at Virginia Commonwealth Statistics 1900-2005.” He also published 1999, Raoul Kopelman) now at Draper University in Richmond. several articles in the Baseball Research Labs (associated with MIT) exhibited a new Todd Houston (PhD 1993, Masato Ko- Journal, The National Pastime ,and Base- medical nano-tool, called “Nano-Tatoo.” reeda) is a Senior Lecturer in the School ball Digest. Currently he is working on When Nano-Tatoo is embedded into the of Biomolecular and Physical Sciences at his next two books: “ The Uniform Num- skin of diabetic patients, its color changes Griffith University in Nathan, Australia. bers of the Detroit Tigers, 1931-Present,” from blue to yellow to red according to the and “Consecutive Games Runs Produced patient’s sugar level. Kami Hull (PhD 2008, Melanie Sanford) was awarded an NIH post doctoral fellow- Streaks, 1920-Present.” Jacqueline Cole (presently a postdoctoral ship. She is working with Professor Barry Jennifer Kwichak (PhD 2007, Nils with Michael Morris) won the ASBMR/ Trost at Stanford University. Walter) has recently become an Assistant Harold Frost Young Investigator Award Professor of Chemistry at Albion College, to attend and present a paper at a meeting George W. Kabalka (BS 1965, PhD 1970 Albion, MI of the International Bone and Mineral Purdue) is a Professor of Chemistry at Research Society. the University of Tennessee. In 2009 he Robert B. Marcus (PhD 1962, Lawrence was elected a Fellow of the American As- Brockway) is retired on Cape Cod after a Douglas Daniels (BS 1995, PhD Scripps, sociation for the Advancement of Science career of research at Bell Labs, teaching La Jolla) has been with Novartis in Boston (AAAS). and research in the Physics and Electri- since 2006. William C. Kaska (PhD 1963, John Eisch) cal Engineering Departments of the New Xinggao Fang (PhD 1999, Arthur Ashe) is a Professor of Chemistry Emeritus after Jersey Institute of Technology and com- has moved to Afton Chemical in Richmond, serving over 40 years in the Department of mercialization of some inventions. He VA. He and his wife have just celebrated Chemistry in the University of California at is still involved in his long-time love of the birth of their daughter Abigail, born on Santa Barbara. His research spanned the ar- creating sculpture and has published a book September 15, 2009. eas of organophosphorus and heterocyclic of jokes and humor, “A Priest, a Minister, Jon P. DeGnore (BS 1991, PhD 1997 U. nitrogen pincer ligands with applications and a Rabbi” (Lulu press). Florida) is an Assistant Professor in the for C-H activation of saturated hydrocar- Liz McDowell (PhD (Biophysics) 2008, Department of Physiology of the Tufts bons; organometallic superbase complexes Nils Walter) is now a Visiting Assistant Medical School. He is the Director of of platinum, rhenium and ruthenium; the Professor of Physics at Carleton College, Proteomics and Mass Spectrometry. synthesis of juxtaposed metal complexes Northfield, MN. of substituted naphthyridine complexes; John Gladysz (BS 1971, PhD 1974 Stan- Marcia Moss electrochemistry of cobalt cyanide com- (BS 1993, PhD 1989 U. ford) was named Distinguished Professor plexes and transition metal carbonyl anions Wisconsin) cofounded BioZyme Inc. of Chemistry at Texas A & M University in of chromium, molybdenum and tungsten. She has developed a urine assay to detect September 2008. He also holds the Dow breast cancer and is developing a protein Chair in Chemical Invention. He has re- Charles M. Kausch (PhD 1989, Arthur therapeutic for the treatment of cancer and cently been named an American Chemical Ashe) works on Polyfluorooxatanes with inflammatory diseases. Society Fellow. Omnova( formerly GenCorp) in Akron, Brandon McNaughton OH. He is the secretary of the Akron ACS (PhD 2007, Raoul Val Goodfellow (PhD 1986, Richard section. His wife Meridith is an internist Kopelman) is an Assistant Research Sci- Lawton) has founded a new company in and they have two children, Emily (12) entist in the UM Biomedical Engineering San Diego, CA and serves as its CEO. and Ian (9). Department. Califia Bio Inc. is involved in collab- Shahid Murtuza (BS 1994, PhD 1999 orative research projects with NIH funded David Konas (PhD 2002, James Coward) Penn. State) has enrolled in the MBA academic research groups and biotech is an Assistant Professor of Chemistry and program in the Kenan-Flagler Business companies. Their interests are in medici- Biochemistry at Montclair State University School at the University of North Carolina nal chemistry drug discovery in the areas in Montclair, NJ. at Chapel Hill. of neurodegenerative diseases, stoke, and James Kornacki (BS 2009) won a poster th Matthew Neu inflammation. award at the 57 ASMS Conference on (postdoctoral 2006-9, Kevin Kubarych) is now an Assistant Profes- Adam Gresiak (PhD 2008, Adam Matzger) Mass Spectrometry in June. sor of Chemistry at Western Kentucky and Lidaris San Miguel Rivera (PhD Herman Krabbenhoft (PhD 1974, John University 2008, Adam Matzger) are both at Dow Wisemean) was a Research Chemist at Sam Pazicni Chemical Company in Midland, MI. GE’s Corporate Research and Development (postdoctoral 2006-9, James They recently celebrated the birth of their Center in Schenectady, NY for over 25 Penner-Hahn, Brian Coppola) is an Assis- daughter.

12 2009 tant Professor of Chemistry at the Univer- Professor McAlpine observed that for BS Ian Steward (BS 2002, PhD 2006 sity of New Hampshire. the starting salary is about $100/ month U.C.,Berkeley) has just started work with Gorka Peris (PhD 2006, Edwin Ve- and for a MS or PhD about $150/ month, Exxon Mobil in Houston. dejs) is currently a Laboratory Leader but afterwards advancement depends on Weilhong Tan (PhD 1993, Raoul Kopel- in Chemistry-Fungicide Department of ability, initiative and personality. A de- man) is a Professor of Chemistry at the Bayer CropScience located in Monheim lightful letter! University of Florida (Gainesville). He am Rhein, near Cologne, Germany. Amethyst Smith (BS 1999) has received also has an appointment in the Brain Insti- Katherine Plass (PhD 2007, Adam a JD degree and is employed by the law tute at Florida and is a Research Professor Matzger) is an Assistant Professor of Chem- firm of Schiff Hardin LLP. She works in at the State Key Laboratory of Chemo/ istry at Franklin and Marshall College, pharmaceutical patent litigation and has Biosensing and Chemometrics at Hunan Lancaster, PA. She won several awards ample opportunity to use her chemistry University, China. including a Dreyfus Faculty Start-up background. Renato Zenobi (Postdoctoral 1991, Raoul Award, Cottrell College Science Award and Zeev Rosenweig ( Postdoctoral 1995, Kopelamn) has become Professor of Petroleum Research Fund Undergraduate Raoul Kopelamn) is a Program Direc- Chemistry at the Swiss Federal Institute New Investigator Award. tor at NSF in the Analytical Chemistry of Technology (ETH) in Zurich. Kendra Reid (PhD 2009, Robert Ken- Division. Liming Zhang (PhD 2004, Masato Ko- nedy) has accepted an offer as an Assistant Harold F. Sanford (PhD 1979, Arthur reeda) moved his research group from Professor at U. Detroit Mercy. Ashe) is a Research Chemist at Fresenius the University of Nevada, Reno to the Melissa (Batchelor) Reynolds, (PhD Medical Care, Lexington, MA. University of California, Santa Barbara 2004, Meyerhoff) has been appointed as- Thomas W. Smith (PhD 1973, Charles in July 2009. He is currently Assistant sistant professor of analytical chemistry at Overberger) retired from Xerox in 2002 Professor of Chemistry. Colorado State University and is now a Professor of Chemistry at the Xinnan Zhang (PhD 2007, Adam Matzger) Samuel W. Root (BS 1940, MD 1943) Rochester Institute of Technology. He was has moved from National Starch and Chem- of Jacksonville, FL sent a copy of a hand recently named an ACS Fellow. ical Company to become a Staff Scientist at written letter which he had received in Kurt H. Stern (MS 1950, PhD 1953 Clark Symyx Technologies in Sunnyville, CA. 1936 from Professor R. K. McAlpine of U.) has written three books on the chemis- James Zimmerman (PhD 2000, Henry the UM Chemistry Department. Dr. Root try of molten inorganic salts. He is also a Griffin) is Associate Professor of Chemistry had inquired what he might expect to do composer and has had several compositions and Associate Director of the Research and earn as chemistry graduate. In reply performed in the Washington, DC area. Academy for University Learning at Mont- clair State University in New Jersey.

In Memoriam We are saddened to announce the deaths of the following faculty, alumni, alumnae and friends of the Department.

David W. Holmes (PhD 1940, Werner Hymin Shapiro (MS 1936) died at the Frey of, “The Organic Compounds of Bachmann) died on January 2, 2009 at the age of 93 on November 1, 2008 in Kirkland, Lead,” published by Wiley/Interscience. age of 94 in Hockessin, DE. Dr. Holmes WA. He was born in Detroit and received John T. Yoke, III (PhD 1954, Robert graduated from Amherst College in 1937 a BS from Wayne State U. in 1934. After Parry) died at the age of 80 on February with a BA in Chemistry. After obtaining his graduation from UM Shapiro obtained a 12, 2009. He was born in New York City PhD in Organic Chemistry with Bachmann, position as a chemist with Ethyl Corpora- and received a BS from Yale in 1948. he did a one year post-doctoral before join- tion (now a part of NewMarket), where Following graduation from UM, he ing the DuPont Company. After 36 years at he would spend the rest of his career. He served in the US Army Chemical Corps DuPont, he retired a Director of Sales for became Assistant Director of Chemistry and was a research chemist at Proctor and the Elastomers Department. In his retire- Research. In 1957 he was transferred to the Gamble. He later held faculty positions at ment Dr. Holes was very active in com- company’s major facility in Baton Rouge, the University of North Carolina and the munity services. In particular he served for LA, where he served as Senior Research University of Arizona. In 1964 he joined more than 25 years with the Service Corps Advisor. He retired in 1985. Among his the Chemistry Department of Oregon State of Retired Executives (SCORE). With his many accomplishments he generated 110 University, where he retired as a Professor wife Barbara (Zechiel) he helped found the patents, mostly in the field of organome- of Chemistry in 1990. Professor Yoke’s Mary Campbell Center of Wilmington, DE. tallic compounds. Notable among these research involved inorganic synthesis and The Mary Campbell Center is dedicated to was a patent on new organomanganese the reactions of phosphorus and nitrogen serving the needs of multi-handicapped, compounds, which became the basis for a ligands in metal complexes. allowing its participants to play an active commercial anti-knock agent in gasoline. role in the community. In 1968 he was the coauthor with Fredrick

U-M DEPARTMENT OF CHEMISTRY 13 Faculty Theodore Goodson, III, Richard Barry Bernstein John Montgomery, Professor. Organic and Orga- Collegiate Professor of Chemistry; Professor, nometallic Chemistry Macromolecular Science & Engineering. Physi- Michael D. Morris, Professor. Analytical Laser cal Chemistry Spectroscopy and Imaging; Electrophoretic Hashim M. Al-Hashimi, Professor of Chemistry; Amy Gottfried, Lecturer III. Separations. Associate Professor, Biophysics. Chemical Kristina Hakansson, Dow Corning Associate Pro- Kathleen V. Nolta, Lecturer IV. Organic Bio- Biology. fessor of Chemistry. Analytical Chemistry. chemistry. Philip Andrews, Professor of Biological Chemistry, Katrin Karbstein, Assistant Professor. Chemical Vincent L. Pecoraro, John T. Groves Collegiate Chemistry, Comp Med & Biology, Medical Biology, Biochemistry Professor of Chemistry. Synthetic Inorganic and School and Director MLSC-Core Tech Alliance Robert T. Kennedy, Hobart H. Willard Collegiate Bioinorganic Chemistry. Proteomics Center. Bioanalytical Chemistry Professor of Chemistry; Professor, Pharmacology. James E. Penner-Hahn, Professor of Chemistry; Mark M. Banaszak Holl, Professor of Chemistry; Analytical Chemistry. Professor, Biophysics. Associate Dean, LSA. Professor, Macromolecular Science & Engineer- Nancy K. Kerner, Lecturer IV. Chemical Education, Biophysical Chemistry and Inorganic Spec- ing. Synthetic and Mechanistic Solution, Surface, Learning and Instructional Methods. troscopy. and Solid State Chemistry. Raoul Kopelman, Richard Smalley University A. Ramamoorthy, Professor of Chemistry; Associ- Bart M. Bartlett, Assistant Professor of Chemistry Professor of Chemistry; Professor, Biomedical ate Professor, Biophysics. Structural Studies of Inorganic, Materials Chemistry. Engineering; Professor, Physics. Analytical/ Biological Molecules. Charles L. Brooks III, Warner-Lambert/Parke-Davis Physical/Biophysical Chemistry. Brandon Routolo, Assistant Professor, Analytical Professor of Chemistry and Biophysics, Physical Masato Koreeda, Professor of Chemistry; Profes- Chemistry. Chemistry/Biophysical Chemistry/Theoretical sor, Medicinal Chemistry. Synthesis of Natural Melanie Sanford, Associate Professsor, Organome- and Computational Chemistry and Biophysics. Products, Small Molecule-DNA Interaction, tallic Chemistry. Heather A. Carlson, Associate Professor of Medici- Chemical Carcinogenesis, Glycobiology. Roseanne J. Sension, Professor of Chemistry; Pro- nal Chemistry; Associate Professor, Chemistry, Kevin Kubarych, Assistant Professor. Physical and fessor, Physics. Physical Chemistry, Ultrafast Computational Chemistry, Drug Design, Theo- Biophysical Chemistry Laser Spectroscopy. retical Biophysics Kenichi Kuroda, Assistant Professor of Dentistry, David H. Sherman, Hans W. Vahlteich Professor Kate S. Carroll, Assistant Professor of Chemistry; Biologic & Materials Sciences, Biomedical Engr., of Medicinal Chemistry; Professor, Microbiol- Research Assistant Professor, Life Sciences and Chemistry. Physical Chemistry ogy and Immunology; Professor, Chemistry; Institute. Chemical Biology, Bioinorganic and Nicolai Lehnert, Dow Corning Assistant Professor. Research Professor, Life Sciences Institute. Biochemistry. Bioinorganic Chemistry, Physical Inorganic Medicinal Chemistry Mary Anne Carroll, Professor of Atmospheric, Oce- Chemistry Jadwiga Sipowska, Lecturer IV. General Chem- anic and Space Sciences; Professor, Chemistry. Mi Hee Lim, Assistant Professor of Chemistry; istry Atmospheric Chemistry. Research Assistant Professor, Life Sciences Edwin Vedejs, Moses Gomberg Collegiate Professor Zhan Chen, Professor of Chemistry; Associate Institute. Bioinorganic, Medicinal Chemistry, of Chemistry. Organic Chemistry. Professor, Macromolecular Science & Engi- Chemical Biology. Nils G. Walter, Associate Professor of Chemistry; As- neering. Biomaterial and Polymer Surface, David M. Lubman, Maude T Lane Professor of sociate Research Scientist, Biophysics Research Biocompatibility. Surgical Immunology; Professor, Surgery; Pathol- Division. Chemical Biology. Mary Sue Coleman, UM President and Professor ogy; Professor, Chemistry. Biological Mass Spec- John P. Wolfe, Associate Professor. Organometal- of Chemistry trometry, Spectroscopy and Instrumentation. lic Chemistry. Brian P. Coppola, Arthur F. Thurnau Professor of Stephen Maldonado, Assistant Professor of Chem- Ronald W. Woodard, Professor and Chair of Chemistry; Associate Chair for Undergraduate istry Electrochemistry, Materials Chemistry. Medicinal Chemistry; Professor, Chemistry. Chemistry. Organic Chemistry. Science Learning Anna K. Mapp, Associate Professor of Chemis- Medicinal Chemistry. and Instructional Methods. try; Professor, Medicinal Chemistry. Organic Charles F. Yocum, Alfred S. Sussman University Dimitri Coucouvanis, Lawrence S. Bartell Col- Chemistry, Chemical Biology, New Synthetic Professor of Molecular, Cellular and Develop- legiate Professor of Chemistry. Synthesis, Methods. mental Biology; Professor, Chemistry, Biological Structures and Reactivities of Metal Clusters and E. Neil G. Marsh, Professor of Chemistry; Associ- Chemistry of Photo Synthesis. Metallobiochemis- Supramolecules. ate Professor, Biological Chemistry. Chemical try, Protein Biochemistry, Electron Transfer Barry Dunietz, Assistant Professor. Theoretical and Biology, Enzymes, Structure, Mechanism and Edward T. Zellers, Professor of Environmental Computational Chemistry Specificity; Protein Engineering and Molecular and Industrial Health; Professor, Chemistry Carol A. Fierke, Chair. Jerome and Isabella Karle Recognition. Environmental-Analytical Chemistry. Collegiate Professor of Chemistry; Professor, Rowena G. Matthews, G. Robert Greenberg Uni- Biological Chemistry. Chemical Biology, Bio- versity Professor of Biological Chemistry; Senior Professors Emeriti: Arthur J. Ashe III, Lawrence inorganic Chemistry. Research Scientist, Life Sciences Institute; Profes- S. Bartell, S.M. Blinder, James K. Coward, M. Anthony H. Francis, Arthur F. Thurnau Professor sor, Chemistry. Biological Chemistry. David Curtis, Thomas M. Dunn, B.J. Evans, of Chemistry; Associate Dean, LS&A. Magnetic Adam J. Matzger, Professor of Chemistry; Associate John L. Gland, Adon A. Gordus, Henry C. Resonance, Vibrational and Electronic Spectros- Professor, Macromolecular Science & Engineer- Griffin, Robert L. Kuczkowski, Richard G. copy of Materials. ing. Organic, Polymers/Organic Materials. Lawton, Lawrence L. Lohr, Daniel T. Longone, Eitan Geva, Associate Professor. Theoretical and Anne J. McNeil, Assistant Professor of Chemistry. Joseph P. Marino, Christer E. Nordman, Paul Computational Chemistry. Polymer and Organic/Materials Chemistry, G. Rasmussen, Robert R. Sharp, Peter A.S. Gary D. Glick, Werner E. Bachmann Collegiate Mark E. Meyerhoff, Philip J. Elving Collegiate Pro- Smith, Leroy B. Townsend, Edgar F. Westrum, Professor of Chemistry; Professor, Biological fessor. Bioanalytical Chemistry, Electrochemical Jr., John R. Wiseman Chemistry. Chemical Biology, Bioorganic and Optical Sensors. Chemistry, Molecular Recognition.

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