EDITORIAL Teaching Physiology in Africa

A Capitol Idea Heinz Valtin Treasurer, International Union of Physiological Sciences; Unlike my predecessors, my President- Chair, Renal Commission of IUPS Elect tour did not take place until after I had been installed as the Society’s Presi- dent. In the past such tours traditionally This conference,which wasinitiated by mouth Medical School, Hanover, NH. By involved visits to undergraduate campuses, the Renal Commissionof IUPS approxi- and large, academic positions in Africa foreign institutions, or other professional mately three yearsago, was held under the (certainly EasternAfrica) pay so poorly that schools. For my tour, however, I chose to joint sponsorshipof IUPS (its RenalCom- virtually every teacher is also in private visit the marbled halls of Congress accom- mission and its Committee on Interna- clinical practice. That is true also of many panied by Marty Frank and Bill Samuels tional Projects)and the International So- or most who teach the basic sciences; from the APS office. ciety of Nephrology (ISN) . The conference therein liesthe explanationthat the 20-30 The tour was conducted last September was hosted by the Kenya Kidney Founda- “physiologists” at the workshop partici- with specific objectives in mind. The first tion and the Kenya PhysiologicalSociety pated actively in the entire conference, was to thank those members of the Con- and organizedand directed under the able including its clinical aspects. gress who have supported the American leadershipof Dr. MohammedS. Abdullah. The meetingwas held at the KenyaMed- Physiological Society’s views in issues con- Dr. Abdullah is the Secretary-Generalof ical ResearchInstitute (KEMRI), a mod- cerning biomedical research and educa- the Kenya Kidney Foundation as well as ern, large, beautiful, well-equipped re- tion. Second, I wanted to urge my own Chairof the KenyaMedical ResearchInsti- searchand conferencefacility in Nairobi. Minnesota delegation to support a joint tute ( KEMRI). The meeting was conducted in the true Congressional resolution that would des- There were approximately 125 partici- spirit of a workshop, with a lively and ignate March 29-April 3, 1987, as “Ameri- pants representingeight African nations: constructiveexchange of information from can PhysiologistsWeek.” Kenya,Tanzania, Uganda,Zambia, Sudan, which all benefited greatly. The introduc- On the whole, the tour proved to be an Egypt, Ethiopia, and Nigeria. Most of the tory exhortation by Dr. Abdullah for the enlightening experience, but not without participantsteach various phasesof medi- EasternAfricans to “not only learn from some misgivings,as I soon learned that cine-physiology and other basicsciences, our colleaguesfrom outside but [also to] most membersof the Congressknow less medicine, surgery, pediatrics, pathology, impart our own experience to them” was aboutphysiology and scientific issuesthan and others-in the medicalschools of their echoed by H. Valtin in his introductory Bill Samuelsand Marty Frank know about respectivecountries. Residents and nurses, lecture, “Someof us from the West know the operationsof the Congress. mostlyfrom Nairobi,also participated. The relatively little about many of the major Scientists,by and large,seldom interact internationalfaculty from outsideof Africa diseasesthat afflict the majority of the with elected officials in the Conress.Al- were R. W. Schrier, Treasurerof ISN and world’s population. We have come here though some scientists correspond with Chairof Medicine at the University of Col- not only to take but also to listen and to his or her elected officials, few scientists orado; Anthony R. Clarkson, Director of learn.” Nephrology, RoyalAdelaide Hospital,Aus- have actually met with the membersof his All topicswere discussedfrom the point or her Congressionaldelegation. Yet, in tralia; KlausThurau, President-Electof ISN of view of physiology, pathophysiology, and Treasurerof the International Council every sessionof the Congressthe senators and clinical aspects.They included water of Scientific Unions(ICSU), Chairof Phys- and electrolyte derangementsin the var- and representativesvote on scientific is- iology, University of Munich, FRG; and sues,most often without a clear under- iousinfectious diarrheas, malnutrition, and Heinz Valtin, Chair of Physiology, Dart- sickle cell disease; edema of various standingof the issues. The scientific community is selling it- causes,especially kwashiorkor and protein Report of ;1workshop on Renal Diseases alzd Elec- energy malnutrition ( PEM); acute renal self short by not keeping elected officials tro&te Disordws i?z the Third World held in Nairobi, ( Colt timed on p. 2) Kenya, June 2-6, 1986. ( Cozz timed on p. 4)

Vol. 30, No. 1, 1987 1 .- ..--- EDITORIAL (Comltedfronrp I)

CONTENTS informed of the issuesraised by legislative EDITORIAL initiatives, especially as to the cffccts of such initiatives in the home district. A Capitol Idea. F. G. Knox 1 Although the staffsof organizationssuch Teaching Physiology of Africa. as the American PhvsiologicalSociety are H. Valtin 1 effective in presenting national concerns to the Congressregarding scientific issues, APS NEW’S the factor determining how an elected of- Centennial Update 5 ficial voteson theseissues is decidedmost ACDP/APS Panel on the Future of often by what he or she hasheard from the Physiology 6 voters back home. The evidence shows that we live in a truly participatory democ- Second Century Founders 6 racy. 136th APS Business Meeting I3 Tm~orhv J Pcnne\. Congre%m.m from m! dr\lrlcl m This is a significant year in our nation’s Mmnc*\orJ Membership Status 10 history. It marks the 200th anniversaryof the Constitution and the convening of the mmd that elected offtclals have full sched News From Senior Physiologists 10 100th Congress.By coincidence, 1987 is ules that allow for only brief vlslts Try to Edward F. Adolph 13 the Society’s Centennial Year. It also make your scheduleaccommodate that of should be the year that physiologists in I)eceased Members 14 the senator or representative While it IS particular and researchersand educatorsin importantthat you arrive promptly for your Edward W. Hawthorne 15 general get to know their Congressional meetmg,It must also be rememberedthat Call for Symposia Nominations 15 delegations. elected offictals frequently have hastily Therefore, I am encouraging ever) called meetingsor are summonedto the 1987 APS Fall Meeting 16 memberof the American PhysiologicalSo. floor to vote on pendmg legislatmn Ke Pl!BLIC AFFAIRS cicty to begin building a communications member,patience is its own reward. channelwith hisor her Congressionaldel- Pleasewrite to your senatorsand to each Congressional Agenda Appears Set for Animal Welfare Legislation 11 egation.I also urge the memberswho will representativefrom your state asking for bc attending the APS Centennial Meeting thetr cosponsorshipof the Jomt Resolution Animals Taken in Break-in; Raid in Washington,DC, to write for appoint- designatingMarch 29-April3 as “American Brings Press Criticism. ments with their senatorsand representa. PhysiologtstsWeek” (HJR 84 in the House, N’. M. Samucls 12 tivc sometime during that week for the SJR28 in the Senate) As you undoubtedly ANNOUNCEMENTS 12 purpose of discussinglegislative needs are aware, our efforts to secure such a and concernsthat affect you and your in- resolution in the 99th Congresswere only OPINION stitution. partly successful.The Senateunanimously On Teaching Physiology to Medical The APSstaff will be happyto work with approved the resohmon, but it failed to Students: A Reply. J. A. Michael 13 you to assurea successfulmeeting. Bill receive the 218 cosponsorsrequired for Samuelsor Marty Frank can provide you passageby the Ilouse. BOOK REVltW 14 with background and viewpoints of your Durmg this APS Centennialyear I urge elected officials and information on the every biomedical scientist to loin in our BOOKS RECEIVED 14 issuesyou wish to discuss. participatory democracy by writing to and PEOPLE AND PLACES 15 In making your appointments,bear in meeting with their elected officials. Your participation can help assurecontinued Congressionalsupport for both the Na-

Publications Commirree: Chairman. P. C. Johnson; tional Institutes of Health and the National The Phpiologrst Members, John S. Cook, William F. Ganong. Leonard SctenceFoundation, provide insightsas to Puhhshed bimonthly and R. Johnson, and Jean McF.. Marshall. Publicafions the imponanceof ammals in research, and Manager and Executive Editor, Stephen R. Geiger; dlstrlbuted b) enccJurage support of the Joint Resolutton Production Manager, Brenda B. Rauner; Editorial designatingMarch 29-April3 as “Amencan The AmtWan Physmloglcal Societ) Stag Laura North and Lorraine Tucker. 9650Rockvllle Pike Subscriptions: Distributed to members as pan of PhysiologistsWeek.” Bethesda.Maryland 2081-1 their membership; nonmembers and institutions, The mteracttonof physiologistswtth the $25.00 per year in the United States; elsewhere $35.00. membersof Congresscan be viewed truly MN0031 9376 Single copies and back issues when available, $5.00 as“A Capitol Idea II each; single copies and hack issues of Fall Abstracts issue when available, $20.00. In I987 subscribers to Martin Frank, Edifor The Physiologist will receive it and the abstracts of the Franklyn G. Knox and Fall Meeting of the American Physiological Society. President Executive Secretary-Treasurer The American Physiological Society assumes no re. sponsibility for the statements and opinions advanced Franklyn G. Knox, President by contrihurors to The Pbysiotogis?. Deadline for submission of material for publica- Past President Howard E. Morgan, tion: Dec. 5. February issue; Feb. 5. April issue; April Harvey V Sparks, Jr., Presrdent-Elect 5, June issue; June 5. August issue, Aug. 5. October Shu Chien. Jay A. Nadel, Nonnan C. issue; Oct. 5, December issue. If you change your Staub, and Aubrey E. Taylor, Councrllors a&es or telephone number, please notify the central offliceas soon as possible.

2 THE PlIYSIOLOGIS’I Dr. Knox Goes to Washington

II vp /efi Roben Dole. Kansas Senalor. and Martm Frank Top nghl Doug Walgren, Pennsylvama Represenrlrlvr .M rddk lcf/ Da\ld Durenbcrger. Mmnesota Senator Center James Wyngaarden, DIrector of NIH Middle rrghl G eorge E 13rown. Jr , Cahforma Reprewnratlve Hottom 1ej/ Rudy Boschwnz, Mmnesola Senator Holrom rrght M anm Frank, Donald Newman, Undersecretary of the Depanment of Health and Human Services. and Wllham M Samuels

Vol. 30. No. 1, 1987 3 Among other outcomes, the IUPS now has TEACHING PHYSIOLOGY myself, so that I invited him to give me a ( Cou titwed from p. 1) a major and highly competent anchor in brief, written resume and an estimate of Africa with whom further efforts in the how much money he might need to com- Third World can be continued. failure (ARF), especially during preg- plete the study in Uganda. The very next nancy, which accounts for approximately day, he handed me a four-page, typewritten 50% of ARF in Eastern Africa; the immune Physiology account; the sum required would be ap- nephritides, due to various causes, espe- On Friday, June 6, I met with approxi- proximately $27,000, almost certainly a cially schistosomiasis; hypertension; ob- mately 30 physiologists who had partici- very worthwhile investment. structive uropathy; drugs and the kidney; pated in the earlier sessions. The purpose A third problem for African physiolo- and renal function during pregnancy, of this meeting was for me to be apprised gists (and physicians) is that they have expecially the toxemias of pregnancy. of some of the problems involved in the difficulty getting their manuscripts ac- A major point that emerged repeatedly teaching of physiology in the Third World, cepted by good, widely read Western jour- as the workshop proceeded is the wealth and in turn to inform the participants about nals. Often, the reason is that the methods of largely untapped epidemiological infor- how physiology is taught in the West. This and the written presentation are not suffi- mation that exists in the Third World. This meeting was held on the main campus of ciently sophisticated. Much of the work point applies not only to endemic diseases the University of Nairobi at Chiromo. that was presented at the workshop im- (e.g., malaria, schistosomiasis, rnalnutri- It was immediately apparent that the pressed me very favorably, and there is no tion) but also to some that are prevalent in main problem for the physiologists (as, in doubt that our African colleagues have developed nations. It is said, for example, much to offer in the way of epidemiologi- fact, for all basic and clinical scientist in cal studies. It is likely that many editors of that renal stones are very rare in Africa and Eastern Africa) is the lack of ready access western journals are unaware of this re- that hypertension wasvirtually nonexistent to current journals and textbooks. The par- on this continent as recently as 1940, search. A start on alleviating the situation ticipants were therefore very glad to hear might be made by having carefully se- whereas now this disease is on the in- about Neuls in Physiological Sciences, crease. The international faculty were star- which wasstarted in part to meet this need lected regional representation on editorial boards, so that manuscripts might be tled to see slides showing a mean systolic in the Third World. None of them had judged, at least in part, by persons conver- blood pressure of 100 mmHg in African heard about NIPS, which clearly illustrates adults. If the observations are correct, that we need to establish channels through sant with the Third World. A final problem listed by the physiolo- there exists a marvelous opportunity to which physiologists everywhere can be in- gists was the need for travel grants and study the natural history of two disorders formed of major developments in our dis- that account for much morbidity and mor- cipline. stipends to permit young African scientists tality in the developed part of the world. to work in laboratories outside of Africa. A second need, not surprisingly, is for The ISN has established such grants for Furthermore, such largelv untapped re- research funds. It will be some time before clinical training. I think it would be good sources suggest one important form of re- such funds become available because one search that might be conducted in Africa can hardly expect that a continent where if IUPS began a similar program for train- at relatively low cost, as well as the impor- starvation is on the increase will support ing in physiological research and teaching. tance of publishing the information in basic research to any great extent. It may During the remainder of the session in widely read and prestigious journals. well be possible, however, that African physiology, I described how the subject is On the final day of the workshop, a physiologists could accomplish some good taught (I distributed the course schedule session devoted entirely to physiology (de- research in collaboration with colleagues from Dartmouth Medical School), and in scribed in greater detail below) was held in the West, wherein the Africans draw on particular how we teach renal physiology. concurrently with the more clinically ori- their wealth of clinical material (malaria, For the latter, I showed a videotape with ented meeting. schistosomiasis, *malnutrition, and so which we open our course at Dartmouth From the very first day, the African par- forth) and the Western associate(s) con- (I left the copy in Nairobi), and I reviewed ticipants indicated that the workshop was tributes analyses using sophisticated in detail two experiments in physiology a landmark in that Eastern African scientists equipment. (analysis of a 24-hour urine sample and who shared an interest in the kidney had Another, limited possibility might be variation in the secretion of vasopressin), never before met to discuss problems that grants to particularly gifted and promising which illustrate water and solute homeo- they face in common. Appreciation was scientists or projects. One example be- stasis, These are simple experiments, per- also expressed that this was “one of those came apparent on the first day of the work- formed on medical students, which can be rare occasions when the international com- shop when Dr. Jehu Iputo from the De- easily performed in African medical munity has decided to team up with the partment of Physiology, Makerere Univer- schools. less privileged continent of Africa in a joint sity, Kampala, Uganda substituted for an- This special session on physiology was educational programme.” So great was the other speaker and presented his studies on very well received by the Africans and in- enthusiasm that on the final day of the disturbances of thermoregulation in mal- structive for the visitors from outside Af- conference, the participants founded the nutrition. He performed the work during a rica. It might. serve as a prototype for fur- Eastern Africa Kidney Association (EAKA). six-month leave at Cambridge, England. As ther activity of IUPS in the Third World. This bodv will encompass all disciplines, he described so graphically, in Cambridge Recommendations from the basic sciences to the clinical, and he had the equipment but lacked the mal- it will concern itself with matters of edu- nourished patients, whereas in Kampala it As a result of discussions with the Afri- cation, research, and patient care. It is was the reverse. Nevertheless, he tackled can participants and organizers, as well as planned that EAKA will sponsor at least the problem with imagination in Cam- with the faculty from outside of Africa, we one meeting per year, similar to the one bridge by studying patients with Crohn’s would make the following points about in Nairobi. The workshop thus served as a disease, with and without malabsorption. future meetings and activities in the Third catalyst so that its impact will reach far This young and enthusiastic scientist World, and specifically in Africa. beyond the single week when it was held. greatly impressed many people, including ( Continued onp. 7)

4 -WE PHYSIOLOGIST Monday, March 30 Pleuary Lecturer: Philip Leder !%a~~~ Lecturers: David Baltimore and APS Business Meeting APS NEWS Floyd E. Bloom A.M. Symposia A.M. 5” !mposia Steroid Hormone Receptors and Their Sleep-Dependent Changes in Homeosta- Mechanism (SEBM) Centennial Update sis: A Systems View (Session 1) Dynamic Behavior of Neurons and Neural The Basis of Micromechanical Behavior of Networks (SMB) With the receipt of 2,367 abstracts and the Lung Microcirculation in Acute Ischemia and the their programming into slide and poster The Five Founders of APS No-Reflow Phenomenon (BMES) Skeletal Muscle Physiology: An Update and sessions,the fabric of the Centennial Meet- P.M. S’Jmposia ing has been completed. As Al Fishman New Directions Regulation of Renal Transport Systems Molecular Biology in Physiology (Session indicated in his Centennial Updates in the 2) APS journals, “The Centennial Celebration P.M. Symposia Cardiovascular Responses to Chronic Por- . . . should be regarded as a woven fabric Vasopressin and Fluid Balance tal Hypertension in which concept and technology consti- Approaches to the Teaching of Problem- Endogenous Antipyretics tute the warp and the weft. In this light, Solving in Physiology Oxygen Transport: Environmental and physiologv is the loom, and the past and Role of Oxygen-Free Radicals in Mycocar- Comparative Aspects the present can be used to predict an al- dial Ischemia and Infarction most endless variety of effects depending Models of the Renal Proximal Tubule Thursday, April 2 on the biological material under investi- (BMES) Plenar-) Lecturers: Solomon H. Snyder and gation, the conceptual framework within Panel Discussion: The New Golden Age of Sir John Vane which it is processed, and the technologi- Physiology: Perspectives on the Future A.M. Symposia cal instruments that can be brought to bear 0f Physiology (ACDP/APS) Body Fluid and Electrolyte Distribution on the raw ingredients from which the During Thermal and Exercise Stress threads are fashioned.” Tuesday, March 3 1 Control Strategies in Physiological Systems The various components of the tapestry Plenary Lecturers: Hector F. DeLuca and Control of Pulmonary Circulation have now been woven together, enabling Roger Guillemin Smooth Muscle: From Membranes to the Centennial Meeting to “disclose the A.M. Symposia Crossbridges (Session 1) full fabric of physiology and point the way Sleep-Dependent Changes in Homeosta- Space Physiology (Session 1) (NASA) toward the future.” The meeting begins on Frontiers of Neuroscience Sunday, March 29, 1987, at the Washington sis: A Systems View (Session 2) New Roles for Oxytocin Cellular Transport of Free Fatty Acids Hilton Hotel with an opening welcome (BALES) and lecture followed by a reception. From Frontiers of Technology for Physiologists Lung Growth and Development Neuromechanisms of Baro- and Chemore- 11:30 A.M. to 1:15 P.M. on each day, there ceptor Reflexes will be two plenary lecturers speaking to Central Mechanisms Controlling Body the “Century of Progress.” Additionally, the Fluid Balance PM. Symposia 25 Centennial guests from abroad will be P.M. SJJmposia Smooth Muscle: From Membranes to active participants in the sessions and sym- Molecular Biology in Physiology (Session Crossbridges (Session 2) posia organized for the meeting. The 35 1) Cardiopulmonary-Neuroendocrine Inter- symposia scheduled for the meeting cover From Conduction of the Nerve Impulse to actions a wide variety of topics ranging from or- Ionic Channels Via Sodium Conduct- Space Physiology (Session 2) (NASA) gans to molecules and from cells to inte- ance The Capillary Function: Historical Perspec- grative physiology. Autonomic Control of the Peripheral Cir- tives and Future Directions On Tuesday, March 31, NIH and APS are culation in Humans Cellular Mechanisms of Mesangial Cell co-sponsoring a session featuring an ex- Role of the Stomach in Regulation of Sa- Contraction traordinary group of scientists to discuss tiety Macromolecular Uptake and Transport in the Centennial of the organization and the Panel Discussion: The Second Century of Epithelia future for biomedical research. Experimental Biology (NIH/APS) 600 P.M. On Thursday, April 2, at the National Closing Lecturer: Sir Andrew Huxley Academy of Sciences, Sir Andrew Huxley, Wednesday, April 1 Reception at the National Academy of Sci- Cambridge University, will deliver the Cannon Lecturer: Karl J. Ullrich ences @ closing address on “Progress and Its Re- verse in Muscle Research,” to be followed by a reception. Because it may not be possible to accommodate all members of the APS at the closing presentation and Reception at The National Academy of Sciences reception at the NAS, we urge you to reg- Thursday, April 2, 1987 ister early for the event, Listed below are the elements that I would like to attend the closing lecture and reception at the NAS on Thursday, should make this a truly outstanding and April 2. memorable meeting. Please print: Name Sunday, March 29 Address 430 Opening Welcome, Lecture, and Re- City State Zip ception; Washington Hilton Hotel Return to APS Membership Services, 9650 Rockville Pike, Bethesda, MD 20814.

vol. 30, No. 1, 1987 5 ACDP/APS Panel on the Future of Physiology

A special session organized by the As- twenty-first century. What can we expect supporting cellular and molecular ap sociation of Chairmen of Departments of departments of physiology to contribute in proaches? These are some of the major Physiology and APS has been scheduled terms of research and education (of grad- issues that will be discussed by the mem- for Monday, March 30, 1987, at 445 P.M. in uate students and medical students)? How bers of the panel: Mordecai Blaustein, the Washington Hilton Hotel. The panel can we reconcile a future in cellular and Floyd Bloom, Isidore Edelman, Claude discussion, entitled “The New Golden Age molecular research with the need to retain Lenfant, Howard Morgan, Walter Randall, of Physiology: Perspectives on the Future a strong toehold in the organ systems ap- Stanley Schultz, and Steven White. The of Physiology,” is designed to air diverse proach? Are we in danger of losing our participation of the APS membership in views and to try to get some consensus on identity (as the discipline of physiology) what surely will be a lively and emotional the direction in which the discipline of because more and more NIH funding is discussion’is strongly encouraged. physiology is headed as we approach the

Second Century Founders

Thomas H. Adair Leon Chesley David B. Gordon c. Y. Kao W. RossAdey S. T. Chiang D. Neil Granger Frederick W. Kasch Edward F. Adolph Shyan-Yih Chou Brydon J. B. Grant Adrian I. Katz Willard M. Allen John A. Clements Harold D. Green Susan R. Kayar Paul D. Altland Hazel Coleridge Paul H. Guth Geoffrey L. Keighley Murray D. Ahose John Coleridge Francis J. Haddy Ralph H. Kellogg Rajen S. Anand Ruth E. Conklin Charles A. Hales Mushtaq Ahmad Khan N. R. Anthonisen Andre F. Cournand Clara Eddy Hamilton Rolf Kinne Henry S. Badeer David L. Crandall Lyle H. Hamilton F. M. Knapp Silvio Baez Julio C. Cruz Chester W. Hampel Ernst Knobil Praphulla K. Bajpai Horace W. Davenport Esther Hardenbergh Leon K. Knoebel Carleton H. Baker Hallowell Davis Alan R. Hargens Franklyn Knox Bruno Balke Domenic A. De Bias Patrick D. Harris Raymond C. Koehler A. Clifford Barger Pierre Dejours Jayne Thompson Hart Kenneth G. Kohlstaedt Bayer AG/Miles Lewis Dexter Katherine B. Hartman Samuel N. Kolmen Leslie L. Bennett Bruce Dill Richard J. Have1 Diana L. Kunze Carl J. Bentzel James G. Dobson, Jr. George A. Hedge Phyllis Kutsky Robert W. Berliner Peter Dodek Ruth M. Henderson Eugene M. Landis Robert M. Berne Robert W. Doty Joseph F. Hoffman Ivan M. Lang Anwar B. Bikhazi Willa H. Drummond Frederic G. Hoppin, Jr. Henry D. Lauson Oscar H. L. Bing James E. Eckenhoff T. Hoshiko James E. Lawler Edward H. Blaine Richard W. E&stein Ernst G. Huf John K. Leach David F. Bohr Ludwig W. Eichna Michael H. Humphreys L. Don Lehmkuhl Judith S. Bond Gilbert M. Eisner Richard W. Hyde Jacob Lemann, Jr. Robert F. Bond Saul J. Farber Eleanor L. Ison-Franklin S. Leonard Stuart Bondurant Eric 0. Feigl Howard N. Jacobson Michael G. Levitzky John H. Boucher Benjamin G. Ferris, Jr. Louis B. Jaques Matthew N. Levy Robert A. Brace Giles F. Filley J. Raymond Johnson Ira J. Lichton John R. Brobeck Alfred P. Fishman Frederic T. Jung Melvyn Lieberman David Brodie G. Edgar Folk, Jr. Jiro Jerry Kaneko Meyer D. Lifschitz Alfred W. Brody George D. Ford John M. Brookhart Robert D. Foreman Chandler McC. Brooks Robert E. Forster David P. Brooks Martin Frank APS Plenary Session Arthur M. Brown William Freas Physiology in Perspective Manfred Brust Charles A. Fuller Walter B. Cannon Memorial Lecture Nancy Buckley Robert H. Furman Wednesday, April 1, 1987 A. Pharo Gagge Theodore H. Bullock 9:00 A.M, Analysis of the Transport Processes in the Howard B. Burchell Morton Galdston Proximal Renal Tubule: Contraluminal Se- Leo K. Bustad Carl Gans cretory Mechanisms Michel Cabanac Kenneth D. Gardner, Jr. Karl Ullrich, Professor Stephen M. Cain John F. Gaugl Max-Planck-Institut fur Biophysik Leon Cander Elizabeth Carlsen Gerst Frankfurt, West Germany Cohn G. Caro Daniel L. Gilbert IO:00 A.M. APS Business Meeting H. Mead Cavert Anna Goldfeder Franklyn G. Knox, President ’ Pa010 Cerretelli Roberta M. Goldring American Physiological Society K. K. Chen Jean R. Gontier --- - __l__l~-~ ----_ 6 THE PHYSIOLOGIST - W. Gregory Lot2 Eliot A. Phillipson F. 0. Schmitt Daniel C. Tosteson Ulrich C. Luft Richard N. Pierson, Jr. William WI. Scott Janett Trubatsch Roy H. Maffly Irwin J. Pincus Gordon W. Searle Karl J. Ullrich Virendra B. Mahesh Ernest A. Pinson Ewald E. Selkurt Max E. Valentinuzzi Elizabeth Painter Marcus Bertram Pitt John W. Severinghaus Glen R. Van Loon Norman B. Marshall Chi-Sang Poon John T. Sharp Herman Villarreal Alexander Mauro Robert L. Post David P. Simpson Margaret M. Von Dreele Jane D. McCarrell Hershel Raff Arthur H. Smith Karlman Wasserman Ernest P. McCutcheon Hermann Rahn Curtis A. Smith Enoch P. Wei Donald E. McMillan J. Usha Raj Falconer Smith E. G. Weir Robert B. Mellins Nathan Rakieten Gerard P. Smith A. Kurt Weiss George R. Meneely Carlos Enrique Rapela James J. Smith Robert M. Weiss Ulrich F. Michael Paul H. Ratz Thomas W. Smith Bernice M. Wenzel Florence K. Millar Walter Redisch Joseph E. Sokal Stanford Wessler David Minard Emerson A. Reed R. John Solar0 John B. West Vu Dinh Minh James B. Rhodes Sidney Solomon Ira Wexler Howard E. Morgan Erik L. Ritman Harvey V. Sparks, Jr. W. J. Whalen Peter R. Morrison Jane C. Roberts Nicholas Sperelakis G. Donald Whedon E. Eric Muirhead James S. Robertson Isaac Starr John I. White Robert M. Nerem Sol Roy Rosenthal Norman C. Staub Herman S. Wigodsky Gunnar Nicolaysen James N. Ross,Jr. N. L. Stephens Walter S. Wilde Nancv Lee Noble Gerald I. Roth John L. Stephenson William D. Willis Eleanore A. Ohr A. Yvonne Russell Daniel J. Stone Charles A. Winter Dennis D. O’Keefe L. T. Rutledge Douglas G. Stuart Andrew L. Wit George A. Ordway Kiichi Sagawa Kenneth Sugioka R. Stewart Wolf, Jr. L. c. ou G. Sant’Ambrogio Lawrence P. Sullivan Lester F, Wolterink Charles R. Park Francis J. Saunders George A. Tanner Clinton N. Woolsev William J. Pearce Wilbur H. Sawyer Aubrey E. Taylor Michael R. Yelich ’ Louis J. Pecora John J. Sayen Michael 0. Thorner Douglas P. Zipes J. C. Penhos James A. Schafer Klaus Thurau Benjamin W. Zweifach Kenneth E. Penrod Harold P. Schedl Robert E. Thurber

TEACHINGPHYSIOLOGY and the local organizer have been identi- 9. Solicit syllabi from major speakers, (Continued from p. 4) fied, have a representative of the sponsor- to be distributed at the conference. 1. Devote major efforts toward distrib- ing international organization make a brief 10. Use the conference as a forum to uting published material to Third World visit to the country in question to establish publicize the various activities of IUPS and countries. As a result of the Kenya work- personal contact. The resulting familiarity other international organizations with spe- ship, the ISN and the Renal Commission with the “scene” and “personae” will help cial interests in the Third World. of IUPS will explore the possibility of es- immeasurably in coordinating the subse- 11. Plan on some form of published tablishing a Medline computer network for quent planning. summary of the conference. Such material Eastern and Northern Africa, and possibly 4. Urge the local organizers to establish will be helpful for review by the partici- for all of Africa. a program of topics and specific speakers pants, and it may aid the local organizers 2. As an alternative to a workship on the as quickly as possible. Such a roster is and organizations in their relations with model for Kenya, send one or two physiol- usually required to solicit support from their governments. ogists from a developed country(ies) to a major organizations, such as ICSU, 12. When appropriate, utilize the con- central location in the Third World for a UNESCO, the International Bioscience ference as an impetus to found local orga- meeting with physiologists from develop- Network (IBN), and others. The impor- nizations that will promote further inter- ing nations on the same continent. Such a tance of starting early with vigorous effects actions among themselves and with IUPS meeting, which might last approximately to raise funds cannot be overemphasized. and other international organizations. one week, should center on problems of 5. In setting a program, allow ample 13. Try to solicit co-sponsorship from physiology in the Third World, the teach- time for discussions, e.g., 15 minutes per other international bodies in order to pool ing of a single subdivision of physiology 30-minute presentation. supporting funds and solicit advice and (e.g., respiratory, endocrine, neuro, etc.), 6. Include a poster session, so that all ideas. In the base of the Kenya Workshop, and review of the latest developments in who wish may present their work. Some the coordination with Prof. Schrier and the that particular subdivision. A meeting of countries will not allow or support attend- ISN was invaluable. this type would have several advantages ance unless the person gives a presenta- 14. Earmark a large share of appropri- over a more extensive conference: it would tion. ated funds specifically for support of travel be less expensive, be much easier to or- 7. Assign the majority of presentations grants to as many participants from Third ganize because less people would be in- to speakers from developing countries; World nations ,&is possible. volved, meet a major need in the Third however, participation by several interna- 15. Require a formal report, including World, and could be easily arranged be- tional faculty is also important. detailed financial accounting, from the lo- cause it would require only a couple of 8. Emphasize the quality and tech- cal organizers at the completion of the weeks’ commitment from the international niques of presentations. If possible, have meeting. For the Kenya Workship, such a visitor(s). the local organizers offer help with design report is being prepared by Dr. Abdul- 3. As soon as the venue for a conference and production of good slides. lah .

Vol. 30, No. 1, 1987 7 American Physiological Society eration of American Societies for Experi- mental Biology, will be outstanding due to 136th Business Meeting the efforts of many members of the Society and under the Chairmanship of Alfred P. Time: 4:15 P.M., Wednesday, October 8, Fishman and Orr E. Reynolds; the Centen- 1986 nial Committee; and the APS staff, Martin Place: Clarion Hotel, New Orleans, LA Frank, William Samuels, and Toby Appel. Everyone is looking forward to an out- I. Call to Order standing program. President Franklyn G. Knox called the An opening ceremony will feature in- meeting to order and welcomed the mem- vited guests representing the origin of APS. bers to the 136th Business Meeting of the This will be followed by a full and exciting Society. program throughout the week leading up The agenda and ballot for the Election to a closing reception at the National Acad- of New Members were distributed to the emy of Sciences. There will be special members along with the Proposed Amend- publications and memorabilia that are on ment to the Bylaws to Extend APS Mem- display at this meeting. This will be a HarveyV. Sparks,Jr., and Franklyn G. Knox bership to Physiologists in All the Ameri- “must” meeting for ALL physiologists and a time to showcaseyour work. cas,and an Operational Guide Proposal for all the Americas was published in the June Restructuring APS Governance. The week of our Spring Meeting will be 1986 issue of The Physiologist.This pro- designated “American Physiologists Week” posal was contingent upon the agreement if a resolution sponsored by Representative I I. Report on Membership of the Latin American physiologists, who Douglas Walgren and Senator Robert Dole A report on the current status of the were very enthusiastic and encouraging receive sufficient cosponsors. membership and deaths since the last about amending the Bylaws. Dr. Knox solicited the help of the mem- meeting were reported by the President- A motion was seconded and passed bership indicating that 218 votes are Elect, Harvey V. Sparks,Jr. unanimously that Article III, Section 2. needed in the House and 25 in the Senate. Regular Members,Section 3. Correspond- Our cup is half full, and time is running A. Summary of Membership Status ing Members, Section 5. AssociateMem- out. Members are urged to contact their The APS membership reached 6,400, of bers, Section 7. Student Members, be congressmen concerning endorsement of which 4,632 are Regular, 16 Honorary, 159 amended by removing “North America” HJ 677 and their senators about SJ 408 Corresponding, 773 Associate, 634 Emeri- inserting ‘the Americas.” proclaiming the Week of March 29-April tus, and 186 Student members (see p. 10). 3, 1987 “American Physiologists Week.” This is an increase of approximately 100 V. State of the Society The publications of the Society continue members since the Spring meeting, thanks Restructuring Society Governance to thrive under the leadership of Paul C. to the efforts of the Executive Secretary, Johnson, Chairman of the Publications Martin Frank. Dr. Knox announced that this meeting is the first step in revitalizing the Fall Meet- Committee, and Stephen Geiger of the APS B. Deaths Reported Since the Spring ing through a thematic approach. A total staff, who was acknowledged for the major Meeting of 615 scientific papers were programmed, role he has had in the successof the jour- The names of those members whose of which 20% were first authored by fe- nals. Record scientific strength and out- deaths have been reported since the pre- male scientists. Carl Gisolfi and the Pro- standing performance resulted from sec- vious meeting were read by Dr. Sparks, gram Advisory Committee welcome first tionalization of the American Journal of who asked the membership to observe a suggestions of the membership for pro- Physiologyand the efforts of the authors moment of silence in tribute to them (see gramming the Society meetings. This Com- and editors. A new publication, News in p. 14). mittee was commended for its efforts in PhysiologicalSciences (NIPS), has been organizing an excellent meeting program. very enthusiastically received. III. Membership The American Physiological Society’s At this point in the Society’s history, an Founders Week Program, March 29-April attempt is being made to strengthen the A. Appointment of Tellers 3,1987, will be the keystone of celebrating sections’ voice in the Society. Council President Knox instructed the member- the 100th birthday of the Society. The looks to strong sections with a greater ship to strike those names from the ballot meeting in Washington, DC, with the Fed- voice in the governance to move the Soci- for whom they did not wish to vote. Tellers ety forward in its next century of progress. M. Anderson, N. Granger, X. J. Musacchia, All members received a letter from the and P. Kober were asked to collect the President concerning Society governance, ballots for the Election of New Members. which was distributed with the agenda as B. Election of New Members well. The proposal was initiated by the Dr. Sparks announced that all candidates Long-Range Planning Committee with in- were elected to membership in the Society put from the membership, sections, and (see p. 10). the Section Advisory Committee. In brief, it recommends providing greater input IV. Amendment to the Bylaws from sections, an expanded Council, a Nominating Committee, and a simplified In compliance with the Bylaws, the pro- voting procedure. It was emphasized that posed Bylaws amendment to extend mem- Martin Frank, HarveyV. Sparks,Jr., and Franklyn G. Council encourages the development in bership in the Society to physiologists in Knox. special interest groups. Dr. Knox asked for 8 THE PHYSIOLOGIST discussion of the proposal in preparation for a retreat of Council following this meet- ing. There has been strong support from those members who were unable to attend the Business Meeting. Responding to a member, who asked if there would be only six sections, Dr. Knox said that the number of sections will not change initially, but some may decide to merge. The number will also depend on the criteria of 100 regular members adher- ing to a section. Members will be asked to check their section preference on the dues notice. A section not meeting the require- ment will not automatically be terminated but it will be given an opportunity to re- cruit members. Dr. Knox announced that the proposed shows to present a paper at the following Another member asked why the Section amendments to the Bylaws will be brought meeting, and another recommendation Advisory Committee chairperson was to be to the membership for vote at the Society’s was to publish the name of the individual an ex officio rather than a voting member Centennial Celebration Meeting. with his/her institution in The Physiologist of Council. This is an appointed and not With no other business, the meeting was an elected office as are the chairpersons of VI. New Business adjourned at 5:00 P.M., October 8, 1986, the Finance, Program, Publications, and “No Shows” New Orleans, LA. Education Committees, who are ex officio Having had three no shows in his ses- Harvey V. Sparks,Jr. members without vote. The Society offi- sion, Dr. Charles Tipton of Arizona ex- President-Elect cers and Councilors are elected by the pressed extreme agitation with the number membership. of “no shows” at a Fall meeting. Following 1986 Fall Meeting Statistics Regarding the election of Officers and the Fall meeting in Hawaii, he also ex- Councilors, it was pointed out that the pressed grave concern about this problem The following figures are from the APS Fall “Thematic” Meeting, October 5-9, 1986, in New present procedure of the membership and asked the Society to take some type of Orleans, LA. nominating candidates for the President- action. However, no definitive action has Elect and Councilor will be continued. been taken. Scientifr’c Registration Members 371’ A list of all nominees advanced by the Therefore, he moved that the problem Nonmembers 229 members for each office will be made of no shows for free communications, both Students 145 available to a nominating committee. The oral and poster, be referred to the Program Retired Members 2 committee, to be composed of members Committee, and that a recommendation for Others 74 of the Section Advisory Committee, will be definitive action be made to Council. The Total 821 restricted to selecting a slate of candidates motion was seconded and passed. * Membership breakdown:APS 355; Society from the membership’s list of nominees. One suggestion was not to allow the no for Experimental Biology and Medicine, 16.

Poster sessionsat 1986APS Fall Meeting, New Orleans, LA. Vol. 30, No. 1, 1987 9 David W. Ploth Franz Von Bruch hausen Aleksander S. Pope1 Walter A. Zin Membership Status James P. Porter Associate Members Keith R. Porter Stephen L. Archer Regular 4,632 Robert F. Rakowski Emeritus 634 Steven M. Reppert Daniel N. Darlington Honorary 16 Jeremy D. Road Claude Deschamps Corresponding 159 Audrey J. Robinson-White Thomas J. Eddinger Associate 773 Charles E. Rose, Jr. Debra L. Forman Student 186 William Rouslin David D. Gutterman Total 6,400 Paul T. Schumacker George Hajduczok Victor L. Schuster Bruce M. Halprvn Karen R. Segal Richard L. Hebert Julian L. Seifter G,ary L. Klinger Newly Elected Members Lois M. Sheldahl Sally A. Lang Arthur William Siebens Mable H. Ornodorff The following, nominated by Council, were elected to member- Judith T. Parmelee ship in the Society at the Fall Meeting, 1986. Pomila Singh David J. Skorton Gordon K. Prisk Regular Members Dan R. Halm William G. Squires Mark Riedv Janice M. Bahr Glenn I. Hatton Bruce A. Stanton Jeffrey Y. Schnader John T. Barron Jane L. Hoover-Plow Arlene A. Stecenko Francis Schwiep Francois Bellemare Patricia B. Hoyer Gordon L. Telford Laurence J. Segil Walter G. Bottje Reed W. Hoyt Mark Toraason Jacques Van Dam Donald G. Buerk Frank E. Johnson James G. Townsel Michael J. Buono Freja Kamel Student Members Patrick P. W. Tso Donald E. Bebout Avinash Chander Kristine E. Kamm Antonios H. Tzamaloukas C. I. Cheeseman Gordon L. Kauffman Marilyn A. Brandt Richard C. Vari Jamie D. Campbell Victor Chen Ingegerd M. Keith Dorothy E. Vatner Yiu-Fai Chen Michael C-K. Khoo Eun J. Cha Steven R. Vigna Edna Chow Curtis E. Chubb William R. Kimball Stephen M. Vogel Philip S. Clifford Cheryl E. King Donald W. Davis James G. Walmsley Karen A. Foster John H. Collins Michael I. Kotlikoff David B. West David J. Combs Yasha J. Kresh Edward E. George David M. Wheeler Marie H. Gleason Melvin Wayne Cooper Fredi Kronenberg Kyra R. Whitmer Ronald H. Cox David D. Ku Christopher D. Hardin Mark L. Zeidel Erik J. Henriksen Daniel J. Crittenden George D. Leikauf David W. Zeigler James C. Delehunt Daniel E. Lemons Richard W. Hicks Casey M. Donovan Bruce Lobaugh Corresponding Members Barbara A. Hutchings Janice G. Douglas William McM. Long Jesper Brahm Randi B. Silver Donald D. Doyle Dennis N. Marple Daniel H. Casellas J. Kevin Smith Calvin Eng Michael A. Matthay Orlando J. Castejon Samuel M. Smith Sharon A. Esau Angele V. McGrady Ching-Ping Chih Mark G. Stewart Robert J. Etches Wayland N. McKenzie Leonardo M. Fabbri Roger L. Stork James E. Foley Michael M. Merzenich Yukisato Ishida John D. Strauss Robert J. Full Lee D. Mitchell Miyuki Kuno Wen Tan Barbara E. Goodman Vahid Mohsenin Giuseppe A. Miserocchi Shirley Whitescarver Mark W. Gorman James L. O’Conner Daniela Negrini William A. Womack Gary J. Grover Gibbe H. Parsons Basim S. Toma News from Senior Bethesda-Baltimore area. His chief hobby family visited, and she expected a visit is trout fishing the Ozarks in southern Mis- from her son and his wife, now living in Physiologists souri. Saudi Arabia, in December. Jane Sands Johnson thanks the Commit- Letters to Roy Greep: tee for its greeting on her 93rd birthday. Letter to Arthur B. Otis: James 0. Davis writes that since his re- After an operation for a fractured hip last Alfred H. Law-ton, who resides at the tirement from his position as Chairman of August, she learned that by the “rules” she Advent Christian Village in Dowling Park, the Department of Physiology at the U ni- would have to leave the Home at Coopers- Florida, writes: ‘I still teach our nursing versitv of Missouri School of Medicine in town. She recently moved to a new place care staff and our community care person- 1982 he has been serving as a consultant twenty minutes away where the room is nel about aging, physiology, and some to Dr. Ronald Freeman and his group, who small but clean, the food good, and no medical conditions. They get Continuing have taken over his former research pro- rules and tension. She reports that she gets Education credit for this. Also I do the gram on heart failure and hypertension. around well with a walker and can balance Utilization and Review for our Nursing He and his wife travel considerably in the a pen, though the muscles are atrophied. Home [and] use my photographic hobby to States and abroad. They attend each year “Thanks be-1 can still read and that along keep the Village in slides for presentations the annual meeting of the National Acad- with exercises keeps me busy and happy.” and to help keep our closed circuit TV emy of Sciences and visit old friends in the On Thanksgiving, her step-daughter and station regularly on the air.”

10 THE PHYSIOLOGIST PUBLIC AFFAIRS

Congressional Agenda Appears Set for Animal Welfare Legislation

Early soundings from the 100th Con- monkeys are the property of the Institute bill introduced in the Senate. gress indicate that the primary agenda for Behavioral Resources but have been The bill has not received any major op- items of animal rights advocates are the maintained since the police raid by NIH. position by the scientific community, and enactment of a law that would give individ- The move toward a legislative confir- elimination of LD50 testing has the support uals judicial standing so that they could mation of standing is believed to be sought of the Pharmaceutical Manufacturers As- sue the federal government for alleged by the animal rights activists as an effort to sociation. Thus passage of the bill in the violations of the Animal Welfare Act and a establish new grounds for possible recon- 100th Congress is probable. law that would prohibit the use of un- sideration by the lower courts inasmuch as Information Dissemination and Research claimed pound animals for research sup- the time has elapsed for filing an appeal of Accountability-This legislative initiative ported by federal funds. the lower courts decisions to the US Su- was introduced by Rep. Robert G. Torri- The Congress also is expected to give preme Court. celli (D-NJ) two Congresses ago but with- serious consideration to a bill that would Congressional Joint Resolution-In a re- out much successbecause of its estimated encourage federal agencies to promote lated action, a renewed effort by the House cost: approximately $4 billion to establish nonanimal alternatives to the LD50 test, a and Senate is anticipated in the reintrod- and $200,000 million in annual operating bill that has been promoted in the last two uction of a joint resolution urging NIH to costs. Torricelli has announced that he Congressesby Rep. Barbara Boxer (D-CA) release the 14 monkeys to Primarily Pri- plans to reintroduce a modified version of and has received virtually no opposition mates, a Texas sanctuary operated by ani- the bill that will be less costly. from the scientific community. mal protectionists. The original version would have estab- Two other legislative initiatives ex- The resolution, cosponsored in the last lished a National Center for Research Ac- pected to receive consideration during the Congress by 209 House members and 19 countability at the National Library of Med- 100th Congress are the proposed Infor- senators, conveys the sense of the Con- icine that would be staffed by 20 biomed- mation Dissemination and Research Ac- gress that the monkeys should be released ical research specialists appointed by the countability Act and a Congressional Joint because they are a burden to the taxpayers President. The Center would conduct full Resolution urging the National Institutes and should be permitted to live out their text literature searches of all animal re- of Health (NIH) to release to a primate normal lives without further invasive re- search done or is in progress in this coun- sanctuary in Texas the 14 Silver Spring search. The monkeys were part of a re- try and throughout the world. monkeys now housed at the Delta Re- search program sponsored by NIH. The staff would review all animal re- gional Primate Center in Louisiana. Pet Protection Act-In a move to reduce search approved for funding by federal All five of these legislative items died in the use of unclaimed animals in research, agencies, and if the project was deter- committee when the 99th Congress ad- legislation is being sought that would pro- mined to have been done or be in progress, journed last October and will have to be hibit the spending of any federal funds for the Center could veto the funding. reintroduced. A capsule view of these leg- the purchase of such animals from pounds A sixth legislative proposal that mav be islative initiatives follows. and animal shelters. The proposal was in- carried over from the 99th Congress would Animal Welfare Act Amendment-As a troduced in the second session of the last be the enactment of federal penalties for result of the failure by animal rights activ- Congress by Rep. Robert J. Mrazek (D-NY) break-ins, vandalism, and theft of animals, ists to gain standing in federal court, an and was supported by 60 cosponsors. data, or equipment from laboratories con- effort is expected to be made to win judi- In essence the bill is a companion to ducting research with federal funds. cial recognition through legislative means. the efforts of The Humane Society of the The proposal was recommended by APS Rep. Charlie Rose (D-NC) is expected to United States (HSUS), which is seeking in the 98th Congress and was introduced propose an amendment to the Animal Wel- state and local prohibitions against the re- in the 99th Congress by Rep. George E. fare Act that would permit individuals to lease of unclaimed pound animals for any Brown, Jr. (D-CA). Although the bill re- file civil suits against agencies of the fed- purpose other than pet adoption. The ceived little support from House members, eral government for alleged failures in en- HSUS has set a goal of total prohibition by it was noted that break-ins of laboratories forcing provisions of the Animal Welfare the year 2000 with the objective of 40% stopped after the bill was introduced and Act. Under current law only the US De- attainment by 1990. A dozen states have resumed immediately after the Congress partment of Agriculture can enforce com- enacted such laws. adjourned. Its reintroduction hinges, by pliance. Humane Products Testing-The Con- and large, on whether the research com- Animal rights activists and organizations gress is expected to give serious consid- munity wants to push for such penalties. have been denied standing by both a fed- eration to this bill, which encourages the The original bill called for fines up to eral district court and a federal court of elimination of LD50 testing. The bill was $250,000 and prison terms up to 20 years appeals. Standing is the recognition by a first introduced in the 98th Congress but for persons convicted of putting an individ- court that a plaintiff has a legal stake in a gained little support. It was reintroduced ual life in jeopardy, and fines of the same civil suit. Three animal rights organizations early in the 99th Congress but did not gain amount and five year prison terms for de- and seven activists have been attempting much support until the second session, struction and theft of property. to sue for custody of the 14 monkeys con- when animal welfare groups started a ma- fiscated in 1981 by police in a raid on a jor effort that resulted in 105 cosponsors Silver Spring, MD, research facility. The in the House. There was no companion ( Con timed on p. 12)

Vol. 30, No. 1, 1987 11 PUBLIC AFFAIRS researchers have to use anesthesia when ( Confhrrred from p. I I) they perform a procedure on an animal. Hawks don’t.” ANNOUNCEMENTS Animals Taken in In Maryland a group identified as True Friends broke into SEMA, Inc., laboratory Break-in; Raid Brings and stole four baby chimpanzees that were James D. Hardy Press Criticism being used for AIDS and hepatitis research Memorial Lecture funded by NIH. Unlike other animal rights Animal rights vandals resumed break-ins activities in the Washington, DC, area, this The inaugural JamesD. Hardy Memorial Lec- of research laboratories within days of the break-in received negative or no publicity ture, “The Parietal Lobe Systemand the World adjournment of the 99th Congress. The from publications that previously sup- Around Us,” will be delivered on Friday,March first break-in was at the University of Ore- ported such activities, including The Wash- 27, 1987,at 4:00 P M by Vernon B. Mountcastle, gon in Eugene. The second took place in ington Post. Johns Hopkms University School of Medicine. The lecturewill be given in the Mary Ellen Hope early December at a commercial research The Montgomery Journal, which in the Medical Education Building, Yale University facility in Rockville, MD. past lauded actions of the People for the Schoolof Medicine and is sponsoredby the John In Oregon the Animal Liberation Front Ethical Treatment of Animals (PETA) and B. Pierce FoundationLaboratory. broke into two laboratories and an office its underground components for incidents and stole 100 rats, 24 rabbits, 18 cats, and at the University of Pennsylvania, the Na- 12 hamsters and caused more than $50,000 tional Naval Medical Research Center in Revised Policy on Humane in damages including the destruction of a Bethesda, MD, and the Uniformed Services Care and Use of $10,000 microscope. The laboratories from University of the Health Sciences, spoke Laboratory Animals which the animals were stolen were used out against this break-in because it dis- for breeding and caring for research ani- rupted AIDS research. The Public Health ServicePolicy on Humane mals and not for research purposes. Refering to the break-in and theft of the Care and Use of Laboratory Animals (PHS Pol- In a statement to the Associated Press chimpanzees as “misguided fanaticism,” icy) has been amended to incorporate changes the Animal Liberation Front said, “This is the Rockville-based newspaper said: mandatedby the Health Research Extension Act just the beginning of our efforts to liberate “Animal rights groups such as True of 1985,Public Law 99-158. The most significant those oppressed in research concentration Friends and PETA have long claimed to changesare members of the Institutional Animal camps in Oregon. We will not allow the inhabit a higher moral plane than those of Care and Use Committee (IACUC) must now be us who do not share their zeal. But they appointed by the Chief Executive Officer slaughter to continue without resistance. (CEO); animalwelfare assurance must now con- You will hear from us again soon.” have not shown it in this case. tain an explanation of training or instruction Of the animals stolen 10 of the rabbits “To those people who took the animals available to all personnel involved in the use, were recovered. “They were dumped on a from the lab, and those who aided and care, and treatment of animals; IACUC evalua- county road about 50 miles away, just hud- abetted them, we offer this observation: If tions must be conducted once every six months; dled together next to the road,” said Greg your moral courage forces you to break the and minority viewsof IACUC members must be Stickrod, director of Laboratory Animal law in order to remain true to your beliefs, included in the reports of the semi-annual re- Services at the university. “Fortunately, you should have the moral courage to ac- views. some nearby residents found them and cept the consequences of your actions with Institutions that have an approvedor provi- returned them to the university.” out hiding behind some dummy corpora- sionally acceptable Animal Welfare Assurance on file with OPRR must submit by July 1, 1987, In noting that the rabbits had been bred tion or underground splinter group label.” an amendment to their assurancethat reflects for research purposes and not capable of the changes that the institution has made to outdoor survival, it was said that “animal William M. Samuels conformto the amended PHS Policy. Copiesof the Public Health ServicePolicy on Humane Care and Use of Laboratory Animals Revised as of September1986 may be obtained from Carol Young Wigglesworth,Office for Pro- tection from ResearchRisks, National Institutes of Health, Building 31, Room 4B09, Bethesda, MD 20892. Phone: (301) 496-7163.

Symposium on Extension of Oxygen Tolerance

The Institute For Environmental Medicine will sponsora one-daysymposium on May 26, 1987, in honor of Dr. C. J. Lambertsenand to celebrate the 20th Anniversaryof the Institute. The symposiumwill featurestate-of-the-art pres- entations oriented toward extension of oxygen tolerance in animal and human models. For further information contact B. Hanley, Institute for Environmental Medicine, 14 Med. Labs Bldg., Univ. of Penna., Philadelphia, PA 19104- 6068. Phone: (215) 898-9100.

Reprinted with permissionfrom The Mo~@omery Journal (Continued on p 25)

THE PHYSIOLOGIST (Michael and Rovick, The Physiologist 26: 225-228, 1983) .and as the basis for entire OPINION medical curricula that are now in place, in one form or another, at nearly a dozen On Teaching Physiology to Medical Students: medical schools around the world. Workable solutions to the general mal- A Reply aise affecting the teaching of medical phys- iology will not be easy to develop. Strong Dr. Edith Rosenberg (The Physioogist at micro-levels of function. constraints on the time available for teach- 29: 45,1986) has described what can only This is not to say that integrative, organ ing an ever growing body of basic medical be called a crisis in the current teaching of system physiology, Dr. Rosenberg’s “core”, science and limitations on the resources medical physiology which has resulted ought to be replaced by cell physiology. available to support such teaching must from 1) replacing the full, “classic physi- On the contrary, students need to under- affect the approaches that we take. Perhaps ology” with a “core” curriculum, and stand the functions of the human body at before attempting to define a core curric- 2) simultaneously abandoning “old-fash- both levels of organization if they are to ulum we ought to ask ourselves why we ioned student laboratories” in which stu- eventually function effectively as physi- teach physiology to medical students, how dents “acquired a thorough understanding cians. we expect them to use the information we of the application of basic physical-chem- However, integrative or regulative phys- impart, and what role this will play in their ical processes to the functioning of the iology is not nearly as easy to teach as Dr. ultimate functioning as physicians. intact awake human being.” Rosenberg implies. The concepts of feed- I would like to close with this observa- As a solution to this crisis Dr. Rosenberg back, system dynamics, etc., are amongst tion. Physiology has created innumerable offers three prescriptions. 1) If only a the most difficult ideas for students to mas- forums through which we can communi- “core” of physiology can be taught, include ter, and success here requires the use of cate the latest, and not so latest, research only integrative, organ system physiology. learning resources such as laboratories, findings from the laboratory, to the point 2) In the place of the now absent labora- and perhaps computers, that can give stu- where it is virtually impossible to keep up tories, use discussions of “hypothetical ex- dents direct experience with the complex with the literature in even a fairly narrow periments” in small group settings to foster functioning of such systems. domain. However, there are few forums in the all important integration and applica- Thus, Dr. Rosenberg’s rejection of the which we can communicate develop- tion of knowledge. 3) Avoid the use of computer seems particularly wrong ments, recent or not so recent, in the teach- computers and computer models in teach- headed in this connection. Whatever she ing of physiology. And more importantly, ing physiology. means by the claim that “computer pro- there seems to be little incentive for those I would like to comment on Dr. Rosen- grams are hardwired”, she is incorrect in of us seriously involved in teaching to even berg’s basic premise as well as each of her claiming that “they cannot incorporate the attempt to communicate with one another, three prescriptions. complexity and variability of the living or- Until that changes I am afraid that most of Dr. Rosenberg’s statement of the prob- ganism.” The program “HUMAN” (Cole- us will continue to “re-inventing the lems confronting the current teaching of man and Randall, The Physiologist 26: 15- wheel” every few years in our classrooms. physiology is basically correct, and if any 21, 1983) simulates more integrative, or- thing, too “kind.” Joel Michael Students are being gan system physiology, in all its complex- Rush Medical College swamped with a flood of facts that they are ity, than we can reasonably expect students Chicago, Illinois expected to memorize and retrieve on to master in their first exposure to human command (during course exams and, of physiology. And there is now a large num- course, the National Board exams). At the ber of simulations of different systems at Edward F. Adolph same time, laboratories and small group varying levels of organization that are discussions are decreasing in number. The being used in teaching physiology at many (1895-1986) result is a full data bank” and little ability different levels (Michael and Rovick, Med- Edward F. Adolph, one of the So. to use or apply that stored information in ical Teacher 8: 19-25, 1986). This is not ciety’s most active members, died any useful way. That is to say, our students to suggest that the computer is a substitute on December 15, 1986. Educated at can’t “put it all together” and they are poor for all laboratories, or that it is the cure-all Harvard, he was associated with the problem-solvers because we are no longer for what ails physiology teaching. It is, Department of Physiology at the asking them to develop those skills. however, a tool that can provide our stu- University of Rochester School of However, Dr. Rosenberg’s proposals for dents with useful experiences that can as- Medicine and Dentistry since the de- curing this malaise are, I think, incorrect sist them in integrating the facts they have partment wasfirst organized in 1925. or at least short-sighted. memorized and can help them to develop He has gained much recognition for First, her rejection of cellular and sub- their problem-solving ability. his work on physiological regulation cellular mechanisms as an important part Finally, I would point out that Dr. Ro- and integration and on adaptation to of “core” physiology, whatever her moti- senberg’s proposed discussions of “hypo- hot and cold environments. Elected vation for doing so, will do our students a thetical experiments”, while probably of to APS in 1921, Adolph was a mem- distinct disservice. One need only reflect great value, are not new, and are merely ber of APS for 65 years. He served as on the rapid development, and medical one example of an approach to teaching President of APS in 1953-1954, was therapeutic applications, of our under- called problem-based learning (Barrows the founder and first Chairman of standing of the roles played by intracellu- and Tamblyn, Problem-Based Learning: the Society’s Education Committee, lar calcium in the regulation of function in An Approach to Medical Education, New and was continuing to serve the So- the cardiovascular system to see how short York, Springer Publishing, 1980). A similar ciety as a member of the Senior sighted this approach is. Students do need kind of discussion has been used in oth- Physiologists Committee. o understand some aspects of physiology erwise conventional physiology courses v'd30,No. 1,1987 13 BOOK REVIEW BOOKS RECEIVED

Anabolic Action of Steroids terone to active and inactive metabolites in dif- Biotechnology.The Renewable Frontier. D. E. and Remembrances ferent sites. This body of work extends over Koshland,Jr. (Editor). New York: AmericanAs Charles D. Kochakian almost the entire history of endocrinology from sociation for the Advancementof Science, 1986, School of Medicine, University of Alabama the days of poorly characterizedurine extracts 400 pp., illus., index, $29.95. at Birmingham, 116 pp., $10.95 to modem molecular biology, and the develop Computers in Medicine. M. Anbar (Editor). ment of androgen physiology is explained as a Rockville, MD: Computer Science Press, 1986, While a graduatestudent Charles D. Kochakian logical, evolving body of thought in a waythat 336 pp., illus., index, $29.95. had the good fortune (genius) of making a dis- makes a significant contribution to the historical Developmental Neurobiology of tbe Auto- covery that provided a breakthrough in endocri- literature in the field. nomic Nervous System.P. M. Gootman(Editor). nology and the further good judgment to utilize The memoir is equally interesting as a reflec- Clifton, NJ: Humana, 1986,440pp., illus., index, this observation as the beginning of a lifetime tion of its time and of ours. Many pioneers in $64.50. career that changed our conceptsof how her. endocrinologywere trained as organic chemists; A Dtficult Balance. Editorial Peer Review in mones modulate biological processes.At least indeed, it is difficult to believethat the advances Medicine. S. Lock. Philadelphia,PA: IS1 Press, since the time of Aristotle it had been general in the field could have been made in one life. 1986, 172 pp., illus., index, $24.95. time by anyone other than a chemist, and the Human Immunogenetics. Principles and knowledge that in many species muscle devel- opment is greater in males than in females and present emphasis on other types of training for Clinical AppIications.J. E. Bernal. London: Tay- that this dimorphism can be prevented if males biomedical research may be a detriment to its lor & Francis, 1986,217pp., illus., index, $18.00. future course of development. The memoir also Neurometbods5. Neurotransmitter Enzymes. are castratedearly in life. Kochakian showed that this promotion of tissuegrowth (anabolism) explains how ideas were exchangedin the early A. A. Boulton, G. B. Baker, and P. H. Yu (Edi- by male hormonescan be monitored quantita- days of endocrinology and describes the seminal tors). Clifton, NJ: Humana, 1986,640 pp., ilius., tively by measuring nitrogen balancein the ur- role played by a few dynamic personalities in index, $69.50. the field such as Ernst Oppenheimer and Fuller Projessor Dirk Durrer. 35 Years of Cardiology ine. This seminal observation was then ex- Albright. As the Laurentian Hormone Confer- in Amsterdam. F. L. Meijier and H. B. Burchell ploited in an imaginativeseries of studies that ences were to Dwight Ingle, the Macy Confer (Editors). Amsterdam: North.Holiand, 1986,676 establishedultimately that the anabolic effectof ences were to Kochakian, providing intellectual pp., illus., $75.00. androgensdoes not require the participation of other endocrine systems,that it is the result of stimulation, criticism, and emotional support. Respiratory Physiology.Second Edition. A. H. Suchinstitutional and organizationalforums that Mines (Editor). New York: Raven, 1986,175pp., an enhancement in protein synthesis of target constitute the framework for science are even illus., index, $19.50. tissues rather than a decreased rate of protein more important for the preservation and pro- Cbaos.A. V. Holden (Editor). Princeton, NJ: breakdown, that protein synthesis is enhanced motion of investigativefunction when economic as the result of primary effects of the hormone Princeton Univ. Press, 1986, 324 pp., illus., in- on nucleic acid metabolism, and that various resources become rate-limiting, as during the dex, 619.95. Depression of the 1930s. In our era, when the Neural Function. M. Wang and A. Freeman individual effects of the hormone are mediated support for biomedical researchappears to be (Authors). Boston, MA: Little, Brown, 1986,210 by the induction of specific enzymes in target waning, such organizations deserve our loyal pp., iilus., index, $18.50. tissues, the exact nature of which varies from Tbe Oculomotor and Skeletomotor System. cell to cell and from species to species. He support. Furthermore, this memoir provides a brief Di$erences and Similarities. H.-J. Freund, U. pioneered the concept that the same hormone glimpse into the dynamics of institutions, partic- Buttner, B. Cohen, and J. Noth (Editors). Am- can have different effects in different tissues and ularly in regard to development of centers of sterdam: Elsevier, 1986, 400 pp., illus., index, recognized that one factor that influences these scientific excellence at many provincial univer- $118.50. differential actions is the metabolism of testos- sities during the educationalexpansion after the Au htroductiotl to Fetal Pbj*siology.F. C. Second World War; that burgeoning was not Battagfia and G. Meschia. Orhmdo: Academic, (and is not) an easy accomplishment. Finally 1 1986,257 pp., illus., index, $45.00. would add that in these pages is described the Cardiovascular Pb)‘siologl: 5th Edition. R. M. best of ail possible worlds-the happycommun- Berne and M. N. Levy. St. Louis: Mosby, 1986, Deaths Reported Since ion of scholars in the pursuit of truth that tran- 261 pp., illus., index, $19.95. scends national boundaries and is the true es- Tbe Heart aad Cardiolpascular @tenI: Sci- the 1986 Spring Meeting sence of science. et@% Foutulatious (A Two-Volume Set). H. A. b-t short, Dr. Kochakian’s autobiography is a Fozztrd, E. Haher, R. B. Jennings, A. M. Katz, Reginald I,. Boyd, San Antonio, TX (s-11-86) paradigm for scientistsyoung and old. and H. E. Morgan (Editors). New York: Raven, T. E. Boyd, Ashland City, TN (2-10-86) Jean D. Wilson 1986, 1,797 pp., illus., index, $225.00. Emmett 8. Carmichael, BirminRham, AL (11-14-85) Dante J. Chiarandini, New York, NY (Feb. 1986) George Clark, Charleston, SC (3-21-86) David Bruce Dill. Santa Barbara, CA (6-18-86) Nicholas R. DiLuzio, New Orleans, LA (7-02-86) Claude Fortier, Ste-Foy, Quebec (4-22-86) Irwin J. Fox, Minneapolis, MN (6-15-86) Request for Historic Photographs Edward W. Hawthorne, WdshinRton, DC (10-7-86) Wayland E. Hull, Seabrook, TX (8-19-U) As part of the APS Centennial Celebration, the Centennial Task Force Jack N. Hunt, Houston, TX (d-14-86) is planning to display a photo exhibit, “A Century of Physiologists,” at William J. Rashkind, Philadelphia, PA (6-06-86) the Washington I-Iilton HoteI, the APS headquarters for the Spring Lewis Schiffer, Lakewood, CO &I. 1985) meeting, March 29-April 1987. We would welcome any donations Ralph W. Stacy, Middleton, OH (3-06-86) 3, Henry E. Swarm, Downey, CA (7-28-85) of photographs of physiologists, old or recent, especially of physiolo- Rudolf Thaner, FreiburR, FRG (3-20-86) gists at work or at APS events, for the APS photo collection and for Clara Torda, Brookline, MA (6-17-86) possible display in the Centennial exhibit. Please send contributions John W. Winken, Bowie, MD (7-22-86) of photographs to Toby Appel, Historian/Archivist, APS.

14 THE PHYSIOLOGIST Edward William Hawthorne (1920-1986) PEOPLE AND PLACES

Paul M. Gross, Ph.D., and Joseph D. Fen- Purpura,a memberof APSsince 1957,IS at stermacher, Ph.D.. received the Heinz Kar- the Albert EinsteinCollege of Medicine of gcr Prize 1986 for outstandingwork. 1% YeshivaUniversit! Grossand Fcllstermacher,of the StateI:ni- APS member Donald A. McAfee, Ph.D , versity of New York at Stony Brook. \vere hasmoved to the Nelson ResearchCenter, elcctcd to AI’S membershipin 19~6 and Irvine. from the City of Ilope Research 1982,rcspcctivcly. Institute. in Duart, CA LouisDiamond, Ph.D., Director of the Roben L. Perlman, M D , Ph D , has Pharmacologyand Toxicology Division in ~noved to the RetardationResearch Center, the College of Pharmacy, University of IJmverstty of ChIcago, and Professorof Kentucky, hasbeen appointed Deanof the Pediatricsand Pharmacoh)gicaland Physi. School of Pharmacyat the University of olog~ca~ SciencesFormerly from the Uni- Colorado. Dr. Diamondhas been a mem- versity of Illinois, College of Medicine, EdwardW. Hawthorne,a memberof the bcr since 1970. Chicago,Dr. PertmanWJS elected to APS American PhysiologicalSocietysincc 1955, R. Paul Robertson,Ph.D., Professorof membershIpm 1973 died on October 6, 1986. Ilc WJS the for- Medicine at the l:niversity of Colorado,has Donald C. Harrison, M D., formerly at mer co.chairmanof the Porter Physiolog) been named Director of the DiabetesCcn- Stanford I!niversny, School of Medicine, Development Committee and past mem- tcr ;II the University of Minnesota.Dr. Rob- has become Senior Vice President and ber of the editorial board of the America?r crtson has lxen 311 APS member since Provostfor Health Affairs at the Umverstt) ~o~rn~aloft’h~siololl)~.On IIau-thorne’srec. 19-6. of CmctnnatiMedical Center Dr Harrison ommendationand persuasion,the Porter ‘l’hc Council for International Eschangc WJS elected to membershipIII 1968 Fellowship Program adopted the mission of Scholarshas announced that JamesE. George S. Malindzak,Jr., Ph D , has ac for increasing the numbers of minorit) Heath,Ph.I)., Professorof Physiology.Uni- ccpted the positionof Professorand Head physiologiststhrough its Physiology De- vcrsitv of llinois, Urbana,was awarded the of the Department of Biomedical Engi. velopment Program. I le also participated Fulbright Scholarship to travel, lecture, neermg, LouisianaTech Ilniversity, Rus in the organization of the Circulation consuh, and conduct adva~lced researchin ton Dr. Malindzak hasbeen an APSmem Group (which later becamethe Cardiovas- Argentinaduring the 1986-87 year. bcr since 1966. cular Section). Victor Hutchison, Ph.D., has been AI’S member Elliott Albers, Ph D , has Howard Ilniversitv is establishingan en. n;r~ncd Prcsident.Electof the AmericanSo- moved to the Laboratoryof Neurocndocri- doived EdwardWilliam HawthorneProfes- cicty of Ichthologists. An APS member nology, George State Universit) sorshipin CardiovascularPhysiology. Gifts siiic~c 1970. Dr. Hutchison is Professorof William A. Dole, M D , AssociateProfcs should be made payable to Howard Uni- %oologvat the University of Oklahoma. sor of Medicine at the I:ntversity of Iowa. versity/Hawthorne Professorship. Attn: Dominick Purpura, M.D.. has been has been appointed Director of Medical EleanorI. Franklin, College of Medicine. clcctcd President of the International Research, Cardiovascularat Berlcx Labo- Howard IJnivcrsity. Washingtqn, DC Brain ResearchOrganization (IBRO). Dr. ratoncs. Inc 20059. - ANNOUNCEMENTS Call for Symposia Nominations (Cot~~iturrdfiom p. 12) Dautrebande Prize For IUPS Congress at Helsinki 1988 APS Spring Meeting Physiopathology The scientific program committee for The APS Program Commntee sollclt\ III ;Iccordancc’ with wishes of its founder.the the Centennial XXX1 International Con. sugpwons from the mcmbershlpfor the “t+dation dc Physiopathologic Professeur 1.u. 1988Annual Mcctmg symposiato bc pre CIUI I)autrchande” will award ;1prize eve? three gressof PhysiologicalSciences meeting in WITS,. This IS an inrernatoxd prize whose aim Helsinki. July 9-15, 1989. solicits sugges- sentediii Las \‘C&IS Because the Commit ;A IO re\vxd an author, or several authors who tions for lecturers, intracongress symposia, tee nill select the scss1o11s In April 198’. have been associated for a long time. for 3 hu. and satellite symposia. The scientific pro- your proposals should be submitted to man or ;mimal clinical physiopathology proicct, gram committee is looking for “thematic your section’sProgram Advisor)’ Commit preferably involving therapeutic implications. If topics” and svmposia that represent the tee (PAC) rt~prt’scntatw by March 15, ntd hc, ;IIKI 31 the decision of the Foundation, most stimulating and productive in con. 1987, or earllcr to rccctve proper consid this prize could he shared by two awardccs or temporary physiological sciences. Sug. eration l‘hr namesof the PAC represen groups. If they are deemed to be equally descrv gested svmposiashould be muhidiscipli- tativcs CJIl bc found on pJ@ xiv of the ing of the prize, the ymgesr will hc fxored. narvand’internationalin scope.Names and FASEB Directory X6/8' Additional infor II> purpose is IO dlow the winners IO continue mattonfor prcpanng proposalscan be ob invcstig;rtlons that are sufficiently advanced as topicsfor considerationshould be submit- ted by March 15, 1987, to the IISNC/IUPS, tainedfrom your PACreprcscntatlve or the IO &WW substantial help or reward. The prize’ will next be awarded in 1988. This prize will c/o Dr. Martin Frank, APS, 9650 Rockville, APSMembership Senx’cs Office (30 I-530 amount to approxlmatclv 3.000.000 HF. Further MD 2081-1or sent to Dr. Kaarlo Hartiala, ‘171) information CJII he oh&ned from the Founda- l)epxtment of Physiology. University of tion hy ivriting to Dr. J. Stdport. Avenue hlla 3. KuoPio, PO Box 6, SF-‘0211 Kuopio, Fin- 5200 Ill’Y I3elgium Applications should hc land by; May, 1* 198-‘. sm hvfore Deccmher 15, 19X’.

15 The Society gratefully acknowledges the contributions received from Sustaining Associate Members in support of the Society’s goals and objectives.

Abbott Laboratories Hoe&t-Roussel Pharmaceuticals, Inc. Pennwalt Pharmaceuticafs American College of Surgeons * Hoffman-La Roche, Inc. Pfizer, Inc. American Critical Care Janssen Pharmaceutics Pillsbury Corporation American Medical Association Lederle Laboratories Revlon Health Care Group Baxter Travenol Laboratories Lily Research Laboratories A. H. Robins Company Berlex Laboratories, Inc. Marion Laboratories, Inc. * Sandoz, Inc. Boehringer IngeIheim McNeil Laboratories * Schering Corporation Burroughs Wellcome Company Medtronics, Inc. G. D. Searie and Company Ciba-Geigy Corporation * Merck & Co., Inc. * Squibb Corporation Coulboum Instruments, Inc. Merrell Dow Research Institute Stuart Pharmaceuticals Dagan Corporation Miles Institute for Preclinical * The Upjohn Company E. I. du Pont de Nemours Pharmacology Warner-Iambert/Parke- & Company NARCO Bio-Systems Davis Ortho Pharmaceutical Waverly Press, Inc. Grass Instrument Company Corporation Wyeth Laboratories Harvard Apparatus * Second Century Corporate Founders

Thematic Approach for 1987 APS Fall Meeting

The 1987 Fall Meeting, scheduled for Invertebrates,” which will deal with as- Mini-theme II, ‘Epithelial Transport in October 11-15, 1987, at the Town and pects of teaching and methodology. the Lung,” will consist of two symposia Couny Hotel, San Diego, CA provides THEME II: Neural Principles of Pattern dealing with “Bronchial Circulation and another opportunity to reflect on our past Epithelial Function” and “Solute and Water Generation. Organizer: R. Lydic. Transport Across the Pulmonary Epithelial and prepare for the future during this, the Theme II is sponsored by the Nervous .Centennial Year for the Society. The meet- Membrane.” ing should be scientifically rewarding and System, Comparative, and Respiratory Sec- As part of the meeting, the ALACF will tions. The theme also includes four tutorial be contributing symposia in the areas of will provide an opportunity to meet with lectures and a workshop examining cur- members of the Latin American Associa- hypertension and neurophysiology. Spe- rent neurophysiological techniques such cific information concerning these ses- tion of Physiological Sciences (AIACF). as the tissue slice preparation and intracel. This year’s meeting will build on the sions will be annnounced later. experience in New Orleans during which jular/extracellular recording in vivo. As is traditional, the Fall Meeting will the thematic approach for the Fall Meeting THEME III: Mokculac Transpnrt & Ex- include the presentation of the Bowditch was implemented. The scientific program change in the Cardiovascular System. Or Lecture. The Bowditch Awardee for 1987 for the 1987 Fall Meeting will consist of ganizer: J. M. Downey. will be D. Neil Granger, who will present three major themes that include work- Theme III, sponsored by the Cardiovas- a lecture entitled “Role of Xanthine Oxi- shops, tutorial lectures, and symposia. The cular Section with assistance from mem. dase and Neutrophils in Ischemia-Induced meeting also includes two mini-themes, a bers of the Biomedical Engineering Soci- Microvascular Injury.” teaching symposium, an afternoon session ety, will include tutorial lectures and two The local arrangements committee, on Career Opportunities in Industry, and workshops dealing with modeling and chaired by John B. West, has graciously a continuation of the series initiated in electrophysiological recording tech- agreed to assist the Society in planning New Orleans dealing with Integrative As- niques. activities in the San Diego area. Through their diligence and assistance, the meeting pects of Physiology. There are three major In addition to the three major themes themes. should become a scientific and social suc- that will run throughout the four-day meet- cess. THEME I: Hypoxia & Hypomerabolism. Or- ing, the program committee approved two All APS members are urged to partici- ganizer: W. Milsom. mini-themes. Mini-theme 1, “Molecular Bi- pate in the 1987 Fall Meeting and thereby Theme I is sponsored by the Cardiovas- ology and Physiology,” will consist of a contribute significantly to the enrichment cular; Comparative; Environmental, Ther- tutorial session entitled “Introduction of of the meeting. The San Diego meeting mal, and Exercise; History; and Respiratory Molecular Biology to Physiologists” and a will be the culmination of the Society’s Sections and is designed to deal with hy symposium entitled “Hormonal Regula- celebration of “A Century of Progress in poxia and hypometabolism in vertebrates tion of Gene Expression.” Plans are being made for several companies to present in- Physiology” and jay the groundwork for and invertebrates. In addition to several the Society’s second century. Q tutorials, plans call for a workshop on strumentation workshops to demonstrate “Limits of Gas Exchange & Transport in molecular biological techniques.

1987 AP!S Fall Meeting ‘Call for Papers” to be Mailed March 13 16 THE PHYSIOLOGIST