2015 Banff/CST Meeting Organizing Corporation (“2015 MOC”) – Co-Directors: Dr. John Gill, Dr. Michael Mengel Members: Anthony Jevnikar, David Rush, Denis Glotz, Kim Solez, Marcelo Cantarovich, Mark Haas, Steven Paraskevas

Joint Banff/CST Joint Banff/CST Program Committee Finance Committee Co-chairs: Dr. Alexandre Loupy and Dr. Prosanto Chaudhury The Banff Schema was first developed at a meeting of pathologists, clinicians and surgeons in Banff, , Canada, August 2-4, 1991 and has become the worldwide standard for the interpretation of transplant biopsies.

• 1991 First Conference • 1993 First Kidney International publication • 1995 Integration with CADI • 1997 Integration with CCTT classification • 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies. • 2001 Classification of antibody-mediated rejection: Regulatory agencies participating • 2003 Genomics focus, ptc cell accumulation scoring • 2005 Gene chip analysis. Elimination of CAN, identification of chronic antibody- mediated rejection. • 2007 First meeting far from a town called “Banff” – La Coruna, Spain. • 2009 Working groups. Meeting in Banff, Alberta, Canada • 2013 Establishment of Banff Foundation for Allograft Pathology The Banff Process Consensus communication in renal transplantation

moderated Banff meetings thesis-antithesis-synthesis

participate Banff Working refinement Groups The Banff community The Banff lesions established by tentative The Banff Pathologists g, i, t, v - score classification Nephrologists consensus in 1991 thresholds Current consensus for Tx-Surgeons diagnostics Lab-Medicine

New members Biostaticians aFeedback concerning weaknesses and strengths by results from Off-springs independent research Molecular Biologists Liver “Omics”-specialists Pancreas Lung, Heart CTA Organizational structure of the Banff Foundation For Allograft Pathology Board of Trustees: K. Solez (Chair), L. Racusen, D. Glotz, J. Demetris, M. Mengel, M. Mihatsch, D. Seron, N. Schmidt

reports to funding reports to reports to Secretary/Treasurer: support Michael Mengel

2015 Scientific program committee: Alex Loupy (Chair) Organ Steering committee Chairs: Mark Haas, Banu Sis, Kathryn Tinkham, Candice Rofousse, Composite tissues: Linda Cendales Chris Bellamy, Lynn Cornell, Carmen LeFaucheur Heart : Rene Rodriguez collaboration Composite tissues: Linda Cendales Kidney: Mark Haas Heart : Rene Rodriguez Liver: Jake Demetris Liver: Jake Demetris Lung: William Wallace and Carol Farver Lung: William Wallace and Carol Farver Pancreas: Cinthia Drachenberg Pancreas/Islets: Cinthia Drachenberg and John Papadimitriou

progress collaboration reports to collaboration Budged proposal collaboration and accountability for meeting costs Banff Working Group (BWG) Leads: Molecular transplantation pathology: Michael Mengel, Banu Sis Isolated v-lesions: Banu Sis, Ed Kraus 2015 Local Conference chair: Quality assurance in transplantation diagnostics: Michael Michael Mengel Mengel and Parmjeet Randhawa C4d-negative ABMR: Mark Haas, Banu Sis, Alexandre Loupy Fibrosis scoring: Robert Colvin, Brad Farris, Michael Mengel Digital Pathology in Transplantation: Jake Demetris Significance of ‘Banff papers’

• 4244 citations of the 9 Banff meeting reports • 790 Banff / Transplantation papers in PubMed • Banff 2003 meeting report (ABMR criteria) = most cited AJT paper • 3 Banff meeting reports are among the top 4 cited AJT articles The Banff Conferences on Allograft Pathology:

I. 1991 The Centre For Conferences - Banff, AB Canada

II. 1993 The Centre For Conferences - Banff, AB Canada

III. 1995 The Centre For Conferences - Banff, AB Canada

IV. 1997 The Banff Springs Hotel - Banff, AB Canada

V. 1999 The Banff Springs Hotel - Banff, AB Canada

VI. 2001 The Rimrock Resort Hotel - Banff, AB Canada

VII. 2003 The University of Aberdeen - Aberdeen, Scotland

VIII. 2005 The Fairmont - Edmonton, AB Canada

IX. 2007 La Coruña, Spain

X. 2009 The Rimrock Resort Hotel - Banff, AB Canada

XI. 2011 Enghien-les-Bains,

XII. 2013 Comandatuba-Bahia, Brazil

XIII. 2015 Vancouver, Canada Target Audience for the 2015 joint CST/Banff meeting: total ~600 expected delegates • Basic Scientists • Pathologists • Immunogeneticists and HLA experts • Transplant Physicians: Internal Medicine, Surgery, Infectious Diseases, Critical Care • Allied Health Care • Students, Trainees, Fellows Joint Program Structure

Banff activies Joint activities CST activities

2015 CST / Banff meeting program Day 1: Monday Day 2: Tuesday Day 3: Wednesday Day 4: Thursday Day 5: Friday Day 6: Saturday Session Potential Banff-premeeting Plenary Session: Progress Report Joint Pleanary session I: Joint Pleanary session II: Concurrent sessions: Banff Banff Working groups meeting summary and CST symposia

08:00 - 08:30 08:30 - 09:00 09:00 - 09:30 09:30 - 10:00 10:00 - 10:30 Coffee break Coffee break Coffee break Coffee break Coffee break Coffee break 10:30 - 11:00 11:00 - 11:30 11:30 - 12:00 12:00 - 01:00 Working Lunch: Banff registration Working Lunch: Working Lunch: CST registration Working Lunch: Lunch: Banff adjourns Lunch: open open

Session Potential Banff-premeeting Concurrent Organ Sessions Concurrent sessions: Banff Concurrent sessions: Banff Organ sessions and CST Organ sessions and CST Working groups symposia

01:00 - 01:30 01:30 - 02:00 02:00 - 02:30 02:30 - 03:00 03:00 - 03:30 Coffee break Coffee break Coffee break Coffee break Coffee break Coffee break 03:30 - 04:00

04:00 - 04:30 04:30 - 05:00 05:00 - 05:30 05:30 - 06:00 Events 6:30 Welcome Reception - Cocktails and Case presentations from varioous Joint Poster Session with reception CST Awards and Joint CST/Banff CST President's dinner snacks. Open bar organs with Wine Beer and Food Gala Dinner