Diabetes Research Institute Foundation Fall 2006 / Volume 35, Issue 1 focus www.diabetesresearch.org DRIMiami • New York • Long Island • California • , D.C.

An Evening Under the Stars Research Institute Foundation (Article on page 14) Receives $23 Million Gift from Donor Estate Gift is the largest in its 35-year history

After watching her two desire to fund research brothers suffer the devastating to find cures for diabetes complications of diabetes, and cancer.” Eugenia J. Dodson of Coral The gift is now the largest Gables, FL, was determined for the Diabetes Research to help cure what she called Institute Foundation in its Patti LaBelle wrapped up the Hamptons “a most pernicious disease.” 35-year history. The extra- summer season with a private concert. She had inherited a modest ordinary donation comes legacy from her late husband, on the heels of a stream but the quiet and unassuming of multi-million dollar D.R.E.a.M.S. Come True woman preferred to live a gifts the Foundation has (Article on page 11) frugal life, invest her money, received in just the last year and grow a fortune that she alone, further underscoring would one day give away. the DRI’s distinction as When she died in Eugenia “Gene” Dodson a recognized world leader December of 2005, just in cure-focused diabetes 24 days short of her 101st birthday, Mrs. research. The tremendous contribution Dodson had amassed an estate in excess of will play a pivotal role in enabling the $35 million. Despite her affluence, the former DRI to bring the most promising new beautician lived her life without any of the discoveries to patients more quickly trappings of wealth because she had a much than ever before. Mayor Michael R. Bloomberg commended higher purpose for her money. She designated Robert A. Pearlman, president and CEO the DRI's research progress. the funds be used for cure-focused research of the DRI Foundation, said, “We are in diabetes and also in cancer, since she deeply grateful to Eugenia Dodson for herself was a lung cancer survivor. Two-thirds creating such a meaningful legacy. This Morrison's Parents Speak Up of the gift will come to the DRI Foundation, landmark gift will transform the lives of (Article on page 7) and one-third will go to the University of Miami millions with diabetes. The funds will Sylvester Comprehensive Cancer Center. support new scientific initiatives and “Gene lived a truly selfless life so she create the J. Enloe and Eugenia J. Dodson could fulfill her philanthropic goals. After Diabetes Center for Translational Research, her beloved Enloe’s death, she husbanded where DRI scientists can harness the power her wealth and made astute investments in of many emerging technologies to cure this blue chip stocks. Her fortune grew over a devastating disease. The significance of this period of more than 50 years,” said Donald gift cannot be overstated in terms of what it E. Kubit of Fowler White Burnett P.A., Mrs. will mean for people living with diabetes Dodson’s attorney and co-trustee of her who look to the DRI with hope.” revocable trust. “Eugenia Dodson’s final Foundation National Chairman Marc S. Despite diabetes, Adam Morrison was estate plan was consistent with her profound Goodman said that a donation of this the third overall NBA pick. (continues on page 3) A Message from the Chairman

Dear Friends, This tremendous gift affords the DRI with great money, as many dedicated people are responsible opportunities to build upon its current research for creating and producing the successful fundraising programs and apply cutting-edge technologies that events throughout our regions. Please take the time As you read in our cover are first becoming available to the scientific community. to read about the tireless efforts of these committed story, the Diabetes Research The DRI is pursuing new directions for restoring volunteers. We extend our gratitude to all of them Institute Foundation has production and assembling new research for giving their time and resources to help fulfill our received the largest gift in teams to investigate promising pathways in tissue goal of a cure. its 35-year history from the late Eugenia J. Dodson, engineering, cell regeneration, protein therapy, I also want to thank each of you for your continued a woman who, literally, wanted nothing more than to nanotechnology, and many other emerging technologies. see a cure for diabetes, a disease that took the lives support. While we have received some extraordinary of both of her brothers. Having survived lung cancer We are witnessing a very exciting time for our gifts, this only raises the bar for what we must herself, she designated that her entire estate, valued organization. This recent gift, while by far the largest, continue to do. We are committed to giving Dr. Ricordi at more than $35 million at the time of her death, be is the latest in a stream of multi-million dollar gifts and the whole DRI team the resources they need to used for cure-focused research in these two diseases. the DRI Foundation has received over the last several expand even further and pursue every single direction months alone. As more and more people learn possible to cure all of our loved ones. Her story is truly remarkable and her selfless about the DRI’s cure-focused research programs generosity is certainly unparalleled. We don’t often and see the results from their charitable investment, hear stories about people who give up life’s luxuries the DRI Foundation has become the organization of Sincerely, in order to help mankind. Eugenia “Gene” Dodson’s choice for their contributions. legacy will live on through the millions of people who will ultimately benefit from her kindness. And Many of these generous individuals were honored her and her family’s names will live on through the at our Cycle of Discovery Donor Appreciation events, Marc S. Goodman permanent funding vehicles that will help speed held in Florida and New York City last spring. But progress toward a cure. generosity does not only come in the form of

Jill Viner Joins DRIF National Board

The Diabetes Research Institute Foundation This past August, she and Cliff hosted more than 300 people in their is pleased to announce the appointment of Jill Hamptons home to raise awareness and funds for the DRI. The philanthropic Viner to its national board of directors. Jill's couple engaged top Miami event planner Barton G. to produce a spectacular personal connection to the Diabetes Research evening of food and drink, complete with a concert by Patti LaBelle. Again, Institute dates back several decades. She is a Jill Viner and her good friend, Barton G., underwrote the entire cost so that graduate of the University of Miami, and during all of the money raised would benefit the DRI. her years in college, she attended the Love and In addition to supporting the DRI, Jill has enriched her community in Hope Ball with her parents. The family's interest many other ways through her concern for humanity, particularly children. in supporting research was One of the programs she established, The Viner Compassionate Care sparked when Jill's brother, Craig Silver, was Program, created in 1995, provides financial assistance to families dealing diagnosed with the disease as a child. with a temporary crisis, such as a medical emergency, helping with mortgage Jill has continued to champion the cause and says that finding a cure for payments or providing for children during the holidays. diabetes has become her top priority. She and her husband, Cliff Viner, have Through Camp Breakaway, another component of the Viner become major supporters of the DRI Foundation, and recently made a six-figure gift. Compassionate Care Program, more than 50 children are able to attend “So much progress is being made at the DRI, and I think we’re so close to a cure. camp every summer. The program provides children with a safe, nurturing Now that my children are older, I have the time, the energy, the drive and the desire to environment while exposing them to new experiences and enhancing do whatever I can to make this dream a reality. This is where I belong now,” said Jill. their self-esteem. Not only is Jill a contributor, she has helped steer other donations to the DRI. In Jill has also used her many talents to chair numerous fundraising events January of 2005, she was honored by Chanel and Saks Fifth Avenue/Boca Raton at throughout Palm Beach County. She is an executive board member of the an elegant luncheon and fashion show held at the Boca Raton Resort & Club. Jill Ruth Rales Jewish Family Service, and is also vice president of special was instrumental in having the Diabetes Research Institute named as the beneficiary events and fundraising. of this successful event. She also underwrote all of the expenses in order to channel Jill, her husband, Cliff, and their two daughters live in Boca Raton, FL. the maximum proceeds to the organization.

2

Gift is the largest in its 35-year history (continued from page 1)

• The J. Enloe and Eugenia J. Dodson Chair plantation into patients. The DRI is using in Diabetes Research at the Diabetes an advanced laser scanning technology to Research Institute at the University of determine the health and number of cells Miami Miller School of Medicine within each islet. New avenues of investi- gation also measure the level of calcium • The J. Enloe and Eugenia J. Dodson that enters islet cells in response to glucose, Diabetes Center for Translational Research allowing them to release insulin. The level of calcium corresponds to the amount of • The Raymond and Russell Johnson insulin released, which is a measure of Fellowship in Type 1 Diabetes Research islet viability.

• Purchase highly-specialized and tech- Islet Cell Regeneration. New evidence Gene’s brothers, Russell and Raymond Johnson, nologically advanced research equipment suggests that islet cells have the potential both died from complications of diabetes. to regenerate in the human pancreas. DRI • Fund new scientific initiatives in cutting- researchers are testing several methods to magnitude affords a unique opportunity to edge areas of diabetes research: stimulate islet regeneration using hormones, move the DRI’s research forward. “This is an growth factors and new drugs. They are also extraordinary gift from a remarkable woman. Drug Discovery Program for Tolerance working to identify the factors that regulate We are very fortunate to be the beneficiary of Induction. Currently, DRI scientists are the formation of insulin producing cells that such self-sacrificing generosity, and look only able to choose among those drugs that have been observed in the pancreatic ducts. forward to stewarding Mrs. Dodson’s gift to pharmaceutical companies make available. fulfill her dream of a cure for diabetes,” he said. The DRI is working to overcome these For more information on these and other The tremendous funding also comes at a barriers by assembling a special Drug new DRI research programs, please see the time when the Diabetes Research Institute is Discovery Research Team to develop the Emerging Technologies section of our website expanding its research programs and applying necessary immune intervention agents that at www.diabetesresearch.org the newest technologies in biomedical research will be owned by the DRI and used without To learn more about the ways you can to restore insulin production. New scientific constraints. Production and use of its own create a legacy by supporting the DRI teams at the DRI are delving into such areas agents will also speed the discovery Foundation, and take advantage of tax as cell regeneration, tissue engineering, cell process of bringing new drugs to patients savings through estate planning techniques, transdifferentiation, and nanotechnology, with diabetes. visit the new and more comprehensive among other cutting-edge areas that are planned giving section of our website. just beginning to show promise in early Tissue Engineering Program. The DRI’s Visit www.DRI.plannedgifts.org or contact research studies. Tissue Engineering team will be expanding Jill Shapiro Miller at 1-800-321-3437. “This couldn’t come at a better time. its programs beginning with the recruitment Mrs. Dodson's generous gift will allow us to of Dr. Cherie Stabler from Emory University create new programs and expand existing ones (see related article on page 8). DRI scientists in several critically important areas of diabetes will be developing new biocompatible research where progress needs to be made. materials and other technologies to “actively Not only will we be able to jump start research protect” islets and promote long-term immediately in these areas, but we will also be survival and function after transplantation. able to bring in additional top tier scientists and their teams to Miami to work with us in Drug Delivery of Bioactive Molecules these important initiatives," explains Camillo within the Transplant Microenvironment. Ricordi, M.D., scientific director and chief DRI scientists, in collaboration with the academic officer of the Diabetes Research University of Miami Bioengineering Institute. “I’m very optimistic that we can department, are working to develop ways to 1. create final strategies that work.” supply islet cell grafts with better nutrients 2. and oxygen, as well as protect the cells How the Gift Will Be Used in the transplant microenvironment. This 1) Gene was a remarkably selfless woman whose ultimate goal was to fund research for diabetes and To perpetuate Eugenia Dodson’s legacy integrated approach may help create more and pay tribute to her remarkable generosity, cancer. 2) J. Enloe Dodson, “the love of her life,” left favorable conditions for long term islet Gene a modest legacy 50 years ago. the DRI will establish several permanent survival and function after transplantation. funding vehicles that bear her and her family’s name. The incredible gift allows the Beta Cell Biology Program Expansion. DRI to expand current research activities, DRI scientists are improving upon methods explore promising scientific areas, and develop to reliably and accurately assess the quality new treatments: of insulin-producing islets prior to trans-

3 Foundation Donors Recognized

Awards from the DRI Foundation's Cycle of Discovery series were recently presented to donors who made major gifts during 2005-2006. The award program corresponds with the Foundation's cumulative giving designations below.

1. 2. 3. 4.

5. 6. 7. 8.

9. 10. 11. 12.

13. 14. 15. 16.

17. 18. 19. 20.

DONOR LEVEL AWARD Benefactors $25,000+ Query Founders $50,000+ Hypothesis Grand Founders $100,000+ Exploration Distinguished Humanitarians $250,000+ Realization Governors’ Society $500,000+ Translation Leadership Council $1,000,000+ Perpetuation Chairman’s Council $5,000,000+ Validation 21. 22. Visionaries $10,000,000+ Innovation

4 23. 24. 25. 26.

27. 28. 29. 30.

31. 32. 33. 34.

35. 36. 37. 38.

1) Michele Bowman and Colonel Joseph Underwood, Perpetuation; 2) Ricardo Puente and his fiancée, Misty Flanders, Perpetuation; 3) Michael Davis, Nurit Gans, and David Kay of the Foundation for Diabetes Research, Translation; 4) Milton J. Walters of Million Dollar Hole-in-One Marketing, Translation; 5) Ivette and Juan Elias Calles, Realization; 6) Bill and Joan Fishlinger, Realization; 7) Piero Gandini, accepting for himself and his wife, Paola, Realization; 8) Martin Granowitz, Realization; 9) Larry and Bonnie Inserrra receive Realization from Northeast Director Sandy Cahn; 10) Risa and Jeff Pulver, Realization; 11) Jill Viner, Realization; 12) Barry and Carole Kaye, Exploration; 13) Mac and Pat Levitt, Exploration; 14) Jacci and Dr. Floyd Seskin, Exploration; 15) Nancy Smith of the Marion A. Roletti Foundation, Exploration; 16) Leonard and Anna Thun, Exploration; 17) Irving and Phyllis Bernstein and Myron and Barbara Bloom, accepting on behalf of the Family of Dr. Adam H. Bloom, Hypothesis; 18) Martin and Gladys Gelb, Hypothesis; 19) Elaine and Herbert Gimelstob, Hypothesis; 20) Shari Gantman of The Health Foundation of South Florida, Hypothesis; 21) Arthur Hertz, Hypothesis; 22) Richard C. Hsia of the Future Leadership Foundation, Hypothesis; 23) Martin and Joan Maddaloni, Hypothesis; 24) “Spa Maven” Sondra Rose, Hypothesis; 25) Sonia Gibson and Deborah Slack of Saks Fifth Avenue Bal Harbour, Hypothesis; 26) Olga and Carlos Saladrigas, Hypothesis; 27) Doug Tannehill of C.H. Robinson Worldwide, Hypothesis; 28) Sari and Michael Addicott, Query; 29) Deidre Costa Major, accepting on behalf of Rita and Frank Castagna of the Americana Manhasset, Query; 30) Joe Cerniglia (right) of Florida Mushroom accepts Query from Florida regional board member Bruce Fishbein; 31) Jane and Lawrence H. David, Query; 32) Peter L. DiCapua of Atco Properties and Management, Inc., Query; 33) Camilo Lopez of Florida Association of Furniture Manufacturers, Query; 34) James Kenyon of Steelcase, Query; 35) Bill and Laurie Landau, with their daughter and son-in-law, Nancy and Josh Gillon, Query; 36) Laura Marinello and Marcy Jurkowitz of City National Bank, Query; 37) Allan Pashcow, accepting for himself and his wife, Louise, Query; 38) Norman and Myrna Ricken, Query;

5 Foundation Donors Recognized (continued)

39. 40. 41 42.

39) Patty and Leonard Schupak, Query; 40) Barbara and Norman Shapiro, Query; 41) June Zanvardine and McKenzie Richards of Abbott Diabetes Care, Query; 42) Shirley Hotto, Heritage Society. Paula Wilson: Passion Personified

Paula Wilson's resume reads like an event development. Through writing grants and rallying planner's date book. Driven and dedicated, she has support from numerous individuals and organizations, spent the last two decades volunteering and Paula helped propel the camp from foreclosure to a fundraising for a number of organizations while financially stable, smooth-running organization. juggling home and family. Their support of diabetes-related causes fanned Years back, she took on the requisite roles of out into other areas. They participated in annual Girl Scout troop leader and PTA president, and was a bike-a-thons, and Paula even chaired a comedy Paula Wilson serves as Chairman of regular fixture at her two daughters' school events, benefit for DYS. the California board of directors. often acting as book fair chair, hospitality chair or And today, she finds herself in another serving on numerous committees and councils. She leadership role as chairman of the DRI Foundation's has also led Sunday school classes and organized California regional board of directors. After joining various fundraising and youth events at her church. the board in 2003 and chairing several of the Paula devoted whatever free time remained to Foundation's fundraising events, Paula was selected they're getting a little bit closer.” On that day, Paula her love of the arts, where she tested her creativity to head this dedicated group to help make an impact witnessed her anecdote brought to life. in different acting roles. in the vast California market. Having gotten her feet wet as chair of the Her tireless dedication to these many worthy “Our passion has always been for the camp,” Foundation's Finding Nemo and The Incredibles activities, however, pales in comparison to the said Paula. “But when we heard the DRI's Dr. Luca benefit screenings and last year's Laugh for a Cure, passion she and her husband, Tom, have brought Inverardi speak there, we learned that there was Paula is now taking on the fourth annual Stand Up to their most important cause of all — finding a great hope for a cure. Now our daughter, Nicole, is a for a Cure comedy event, scheduled for November cure for type 1 diabetes, the disease that struck counselor at the camp, teaching kids to live with their 12 at The Improv in Los Angeles. their eldest daughter 17 years ago when she was diabetes, so we can focus our energy on the cure.” But in her larger responsibility as chairman of just 3 years old. “There are two things about the DRI that the board, her focus is to broaden sources of Together, Paula and Tom immersed themselves really excite me,” she explained, “the fact that the funding, differentiate the DRI Foundation from in Diabetic Youth Services, Inc. (DYS), a nonprofit work is cure-focused, and that DRI scientists share other local diabetes organizations, and build upon organization they founded with three other couples their results.” previous successes. in 1996. The organization was formed for one Recently, Tom and Paula visited the DRI. During “We want to move in the direction of adding purpose — to support and maintain Camp Conrad- their tour of the Institute, Paula was vividly reminded more fundraising elements. I want Southern Chinnock, a Los Angeles summer camp for kids of the words she would often repeat to her daughter. Californians to know that their dollar will go a little with diabetes that had lost its funding. “Since she was in kindergarten, I would tell Nicole further at the DRI,” she said. “Finding the cure In addition to fundraising and volunteering for that every day people are going to work, and their must be a collaborative effort, and I think that's the camp, Paula was employed as its director of job is solely to find a cure for diabetes. Every day what makes the DRI very, very special.”

66 STANDING BEHIND “THE STACHE” Wanda and John Morrison speak up about their star athlete son

Wanda and John Morrison have mastered the Wanda explained, “He just didn't want to leave art of teamwork. It's apparent in conversation as each the game. It took a while for him to get used to it.” finishes the other's last sentence. Maybe it stems His devoted mom would sit directly behind the from a solid foundation and 32 years of married life. bench, assisting in glucose checks during time-outs Perhaps it ripened over time as they raised three and carrying an arsenal of insulin and snacks. children together, or sprung from necessity when Wanda remembered one heart-wrenching experience their youngest was diagnosed with type 1 diabetes. when as a high school junior Adam suffered a Wherever it originated, this warm and loving couple severe insulin reaction during a game. Moments after the Charlotte Bobcats drafted him, has passed the asset along to their kids, and “He said to me, 'Mom, there's only one thing Morrison proudly displays his new team jersery. especially to their youngest child, Adam Morrison, that can stop me, and that's diabetes.' My heart 22. Selected by the Charlotte Bobcats as the third ached,” said Wanda, but that moment was the overall pick in the 2006 NBA draft, Adam has taken impetus that led the family to a nutritionist, who Adam's style of play has drawn comparisons this team mentality to a whole new level, while provided them with a better understanding of how to , and not so coincidentally, the Hall of overcoming the challenges of this disease. to control the disease and got Adam on the right Famer is Adam's favorite baller to have ever played “There are several professional athletes that track to an enormously successful career. “Tough the game. But it's comparisons to former NBA center play a variety of sports, and they have diabetes,” as it was, that was the trigger for getting Adam Chris Dudley, who played with type 1 diabetes for said John of his son. “I think being into athletics what he needed to excel.” 16 seasons, that has reminded many that diabetes has actually helped Adam stay in control of this A prolific scorer, Adam averaged more than does not equate to disability. disease — the discipline, the practice, his work 25 points per game at , located Never allowing diabetes to determine his ethic, and tenacity. He refuses to lose.” in his hometown of Spokane, WA. The 6-foot-8, future, and simply by following his dreams, Adam “He's a warrior, on the court and off,” Adam's 205-pound forward led the NCAA's Division-1 in has set a strong example for his younger fans. mother, Wanda, added. “He'll do whatever it takes scoring last season and was hailed West Coast “Adam never set out to be a role model, but I to win. That aspect of his personality comes out Conference player of the year before announcing think he's become a good one,” Wanda proudly with his diabetes, too. He won't let anything interfere that he would forgo his senior year for the NBA. An stated of her son, who happens to sign countless with his dreams.” aggressive competitor with a killer instinct and a autographs but always takes extra time for kids However, that wasn't always the case. wicked jump shot, Adam is adored by fans for his with diabetes. “When he was first diagnosed, Adam Diagnosed at 14, Adam avoided the dreaded charismatic personality, trash-talking tongue, and didn't really have a mentor with diabetes to look up label of being “different” by heading to the bathroom that trademark, patchy mustache that earned him to. That's why it's so important to him now — to when he needed a shot of insulin at school. On the the nickname, “The Stache.” be that person for others.” court, this new life-necessity turned into a nuisance. In college, he perfected his pre-game ritual to If Wanda and John can offer any advice to a science in order to keep his glucose levels under other families like theirs, it is to always encourage control. On game day, he eats the same meal two your children to chase their hopes and dreams, hours and 15 minutes before tip-off, using a pump regardless of diabetes. through warm-up, disconnecting and taking insulin “We worry just like any other parents,” said manually if necessary during the game. Then, he Wanda of the intense NBA schedule and the hooks back up to the pump after the buzzer. possibility of injury that all athletes face. “That's Despite the myriad accolades Adam received our little boy out there. Having this disease might throughout college — plus the fact that he's a make a child's dreams harder to reach, but you can clutch performer who can get a shot off from never give up hope,” Wanda said, holding back tears. anywhere, some teams might have considered his The payoff? diabetes to be an insurmountable obstacle. However, “Adam's dream has come true, and we are after selecting Adam, it's clear that , unbelievably proud of him,” said Wanda. the new operations chief and part owner The future? of the Charlotte Bobcats, believes he has what it “A cure for diabetes is on the horizon, and we At the John R. Wooden Award Ceremony, Wanda and John Morrison stand proudly with their son, takes to outrival opposing defenses during the 82- believe it will happen in his lifetime,” she concluded. who was one of the top ten Wooden All-Americans game pro schedule. and one of five finalists for this prestigious award.

Want to know more? • Learn about Adam's initial diagnosis and how the Morrisons dealt with it together. • Read about the family's history of type 1 diabetes and Adam's introduction to basketball at the age of 13 months! • View additional photos and more. For the extended article, please visit our website, www.diabetesresearch.org.

7 Dr. Camillo Ricordi Receives DRIAround the DRI Transplant Award In July, DRI Scientific Director Camillo Ricordi, M.D., received The Cherie Stabler, Ph.D., Transplantation Society Roche Award for Outstanding Achievement in to Head DRI Tissue Engineering Lab Transplantation Science (Clinical). The award was presented during The Diabetes Research Institute is pleased to welcome Cherie Stabler, Ph.D., as the World Transplant Congress, the Director of the Tissue Engineering Lab. Dr. Stabler comes to Miami from Emory largest biennial international trans- University School of Medicine in Atlanta, where her research focused on the design and plant event that took place this year development of islet encapsulation techniques and the study of how biomaterial barriers in Boston. can protect the fragile implanted cells from the strong immunological and inflammatory responses of the recipient. The Transplantation Society's Tissue engineering holds great promise for enhancing islet survival. At the DRI, Dr. Stabler's research will build recognition awards are given to a on existing methods to construct new biocompatible barriers, such as complex “scaffolding,” that may offer more recipient who has made outstanding immuno-protection to the transplanted islets. contributions in transplantation. She will also investigate ways to attach specific proteins within or on the surface of the protective barriers, such as anti-inflammatory agents. By combining biomaterials with active proteins, it may be feasible to generate materials capable of “actively” enhancing the islet environment, thereby resulting in increased survival and function of the insulin producing cells. Another area of Dr. Stabler's research involves the use of noninvasive imaging techniques, specifically MRI and MRS (Magnetic Resonance Imaging and Spectroscopy), to assess tissue engineered implants. By applying MRI/MRS techniques to islets, researchers hope to monitor the structure and viability of transplanted islets without disturbing their environment. The ability to observe islets post-transplant is critical for understanding their function over time. Dr. Stabler's work complements the DRI's current efforts to assess the health and quality of islets prior to transplantation into patients. “I am very excited to have the opportunity to work at the DRI where there is a team that combines every aspect of diabetes research, as well as a strong focus on tissue engineering. It's really unique,” says Dr. Stabler. “I'm also very Dr. Kathryn J. Wood, president of impressed with the willingness of Dr. Ricordi and the whole Institute to openly share their work with the research community. The Transplantation Society, and The DRI is regarded worldwide as a top-notch research facility. Joining their team for the research reputation is wonderful, Zuzana Lindberg of Roche present but going there for the research collaboration makes it even more meaningful.” the award to Dr. Ricordi. DRI Federation Gains New Members

Four additional research centers have joined the Diabetes Research Institute Federation, bringing the total number of members to 12, and representing 10 countries around the world. The recently-launched DRI Federation is the only global collaboration of its kind that unites leading research centers to concentrate solely on curing diabetes through tolerance induction, transplantation of islets and other insulin producing cells, stem cell therapies and regenerative medicine strategies. The newest members to join this research alliance are: • DRI-Geneva at the Cell Isolation and Transplantation Center at the University of Geneva, Switzerland • DRI-Oxford at Oxford University, England, U.K. • DRI-São Paulo at the Universidad de São Paulo, Brazil • DRI-Ümea at the Centre for Molecular Medicine, Ümea University, Sweden Each partnering center contributes a specific research expertise to the goal of curing the disease as illustrated in the integrated research approach or “roadmap to the cure” that was developed by the DRI and published in 2005 in the journal Transplantation (see diagram). By entering into this formal alliance, the researchers have agreed to put their individual interests aside and share all knowledge and information in what is typically a very competitive environment. The achievement of the overall goal — a cure for diabetes — is the driving force behind this worldwide collaboration. For more information on the DRI Federation, please visit our website at www.diabetesresearch.org

8 Under the Microscope with Alberto Pugliese, M.D.

type 1 diabetes. How could the results of backed up by studies in rodents. If we at your study impact those suffering from the DRI can discover the necessary elements this disease? that cause this transdifferentiation, we may be able to learn how to promote these A. In the article, we showed that changes and the formation of new beta dendritic cells may be a key in the cells in people with long-term diabetes. development and sustenance of 'self- There are many different mechanisms tolerance' in the human immune system. involved here and the situation may be (Self-tolerance is the immune system's difficult to mimic. But by studying the ability to recognize insulin as a good ductal cells that express insulin in these hormone, for example, and therefore not patients and investigating their genetic attack it.) Our group was the first to show profile, we may discover genes that play a that human dendritic cells in the thymus key role in this phenomenon. Novel tech- can express insulin and that these cells nologies available to the scientists at the For the past 12 years, Dr. Alberto can also be found circulating in the body. DRI, such as laser capture technology and Pugliese, a Research Associate Professor This discovery may be a key to why some gene chips, should allow us to study of Medicine, Immunology and people develop diabetes or other these key pathways on a molecular level. Microbiology at the Diabetes Research autoimmune diseases. We suspect the Institute (DRI), has focused his work amounts of insulin expressed in the Q: Islet transplants at the DRI continue on how genetic resistance impacts thymus and by the dendritic cells control to show promise. What studies are you insulin-dependent diabetes. His research the risk of developing autoimmunity that currently involved in? has allowed him to uncover novel ideas targets insulin and, in turn, pancreatic that may better help him and his co-inves- beta cells. If this source of insulin is A. One of the projects we are involved tigators understand the complex nature reduced, the body may see insulin as in through the Immunogenetics Program of this disease. foreign. If this happens, the immune is the monitoring of islet transplant system will see insulin-producing cells patients for several types of immune As part of his current NIH grant as foreign, as well, and attack, destroying responses associated with the development supporting his research on autoimmunity, beta cells and creating a diabetic state. of type 1 diabetes. We can test these Dr. Pugliese is looking into the idea that Our goal is to discover the molecular responses to see if they are factors in the insulin-producing cells may regenerate. mechanisms that allow the dendritic cells long-term survival of a transplant. We He is also investigating the possibility to express insulin so that they could be also are establishing assays to monitor the that certain cells may “transdifferentiate,” used to treat people with diabetes by number of autoimmune cells circulating in that is to say a cell may be able to change reining in unwanted autoimmune blood. These are not the T-cells that its function when necessary for survival. responses against the islets. This also cause rejection of the islets but immune may be relevant for the long-term success cells that specifically target insulin- By taking this multi-prong investigative of islet transplants. producing cells - the same kind of approach, Dr. Pugliese, who is also the head immune cells that cause diabetes in the of the Immunogenetics Program at the Q: You say that ductal cells could become first place. We need to find out if the DRI, suspects these two phenomena may insulin producers. Why is this important? immunosuppressive drugs that prevent provide further insight into the problem of rejection can also keep these immune autoimmunity as it relates to the rejection A. We noted in several patients who cells from coming back. If we obtain of pancreatic and islet transplants. received pancreas transplants that the evidence that these cells return and ductal cells, cells that make up the negatively affect the transplanted islets, Furthermore, if the theories about cell structure of the pancreatic duct, in the then we need to find ways to them. regeneration and transdifferentiation can transplanted organs expressed insulin. There are several ongoing studies that be proven and replicated, doctors could This is not a normal finding, as insulin are evaluating therapeutic regimens that provide treatments for their patients not is only expressed in beta cells. This may have efficacy, and those studies will only to ameliorate the disease, but per- phenomenon may be a way of compensat- provide information that is relevant to haps to reverse the onset of type 1 dia- ing for the loss of insulin-producing islet transplant patients, too. In the end, betes altogether. cells, whereby cells that do not normally we need to make sure that the immune produce insulin change their role in the system is properly controlled to ensure that Q: In your August 2005 article published body and in fact start producing insulin. it does not harm the transplanted islets. in the Journal of Immunology, you We are putting much time into this discussed your study of dendritic cells and “survival technique” theory, which is also

9 An unforgettable weekend retreat

Thirteen families from South Florida's tri-county area, with kids of varying ages, backgrounds and ethnicities, gathered for the Deliver the Dream Retreat Weekend at the Westgate River Ranch in Lake Wales, Florida. Their many differences were minimal in comparison to the one thing they did share — a connection to diabetes. For the long weekend of April 6-9, the Diabetes Research Institute partnered with Deliver the Dream, a not-for-profit organization that provides a respite for families facing serious illness or crisis by helping them to enhance coping skills, reduce stress and cultivate relationships. Many of the kids with diabetes at the retreat had never even met another child with the disease and were happy to experience an environment where carb-counting and glucose testing was the norm. On the first evening, the families sat around the campfire, singing songs, roasting marshmallows and eating s'mores. Though their blood sugars skyrocketed, the pump-users couldn't wait to compare correction bolus counts the next morning. Additional weekend activities included horseback riding and pony rides, fishing, miniature golf, airboat rides, archery and swimming, plus a costume party, a petting farm, teen movie nights, a rodeo, and so much more. The DRI's Ana Maria Avila, Allison Wick, MSN, ARNP-C, CDE and Jane Sparrow- Bodenmiller, RN, CDE, C.P.T. were on site to ensure a safe, healthy atmosphere, and Wendy Rappaport, Psy.D., L.C.S.W. led separate discussion groups for moms, dads, and kids. Then, she brought everyone together for some surprising realizations. Parents explained their constant concern regarding their kids with diabetes; siblings revealed their true emotions; and those with diabetes were able to see life from a fresh perspective. At the retreat's end, all the participants exchanged phone numbers, email addresses and promises to keep in touch. Though they arrived as strangers, each individual left with a shared sense of belonging and a network of new friends who live close by.

1) Alexander Smith, Shane Wilson and Lucas Wilson scale the rock- climbing wall. 2) With the help of a Deliver the Dream volunteer, Alexander Alonso assists 2 1/2 - year-old Giancarlo Alfonso as he pets a calf at the petting farm. 3) Todd and Samantha Green peer over the shoulder of Hope the Bear at Charlotte Yedo, Jake Miller, and Giancarlo 1 2. Alfonso, during welcoming activities. 4) Many of the families met at the DRI and traveled together by bus. Pictured: (back row) Stephanie Yedo, Alexander Alonso, Gabriela Sullivan, Madeline Yedo, Karen Ripoll, Charlotte Yedo; (aisle) Patrick Sullivan, Brooke Miller; (seated) Emma Dorante, Emmanuela Diaz, Giancarlo Alfonso, and Maria Rodriguez.

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Rodkin Jewels and Mayfair Jewelers, a Gucci Bouvier handbag, and an array of D.R.E.a.M.S. in the City sports memorabilia generously donated by Northeast board member Peter DiCapua. Funds also were raised via naming opportunities, whereby big-hearted donors pledged to underwrite much-needed equipment for the Institute. ...a dream come true The event chairpersons, along with Junior Chairperson Hayley Friedman Morrison and the committee, extended their heartfelt appreciation to the many generous people The inaugural D.R.E.a.M.S. (Diabetes Research, Elegance and Modern who made the event a success. Diamond D.R.E.a.M.S. Sponsors included: Bear Sophistication) in the City event impressed more than 200 guests at New York's Stearns, The Stacy Joy Goodman Memorial Foundation, Katten Muchin Rosenman West Side Loft on May 18. Co-chaired by Northeast regional board members LLP,The Kenmar Group, Risa and Jeff Pulver, Adrienne and Arnold Rubin, and Hazel Risa Pulver and Samantha Shanken Baker, the event raised nearly $240,000. and Marvin Shanken. Golden D.R.E.a.M.S Sponsors “The idea of the event was to have fun, get together for a good cause were: Judy and Jason Chudnofsky, DPM Mellon, and raise funds to find a cure, and we achieved all three,” said Samantha. Hirshleifer's, Lehman Brothers, Vikki and Michael Price, “D.R.E.a.M.S. in the City truly showed how New Yorkers love to step forward and UBS Securities, LLC. Silver D.R.E.a.M.S Sponsors for a good cause in order to make a difference.” included: Citigroup, Doug Davis, Kelly and David Halpert, Honorary Committee Member Joseph R. Gannascoli, better known to fans of Edith and Norman Weisfeld, and Diane and Howard Wohl. "The Sopranos" as Vito Spatafore, mingled with the crowd as they enjoyed fabu- In-kind sponsors were: Candid Litho Printing Ltd., Col lous food and drink, plus music by DJ Tom Finn, formerly of Studio 54. The Solare, Gloria Ferrer, Fiji Natural Artesian Water, Emeril evening was highlighted by an appearance by Mayor Michael R. Bloomberg who Lagasse, pulver.com, Wine Spectator, and Yamazaki. was introduced by DRI Northeast Board Chairperson Tom Stern. Mayor 1. Bloomberg spoke eloquently about New York City's commitment to support diabetes 1) DRIF President and CEO Robert A. research, and he commended the high quality of research underway at the DRI. Pearlman enjoyed speaking with Honorary “We were all moved that Mayor Bloomberg took time from his hectic Committee Member Joseph R. Gannascoli schedule to join us for a good cause," said Risa. "His words of support in the (A.K.A. Vito Spatafore of “The Sopranos”). 2) Co-Chairs Risa Pulver and Samantha drive to find a cure were deeply felt by everyone in the room.” Shanken Baker and Junior Chair Hayley The evening featured a stellar silent auction, with such spectacular Friedman Morrison enjoyed the success items as a weekend at Twin Farms in Vermont, exquisite jewelry from Loree of the event. 2.

diabetes-related complications. The passion and endless efforts of these young men were evident in the success of this very hip party. HIP HIP HOORAY! Revelers returned again and again to Café Sambal's station, where Chef Gerdy Rodriguez offered smooth, green mojito shots and braised beef short ribs with potato foam and candied onions. Perricone's Marketplace gave pasta lovers a healthy The “Hippest Happy Hour in Town” played out its moniker Saturday, alternative, whole wheat fusilli reggiano, and Tropical Chinese Restaurant offered a June 3, at the 15th annual Feast Among the Grapes, South Florida's premier delectable Peking duck. Kefi presented an extravagant Mediterranean antipasti wine tasting and culinary event, held in cooperation with Wine Spectator. spread as well as mouth-watering chocolate mousse. Guests with a sweet tooth also More than 1,000 guests glided from booth to booth at the Radisson Hotel enjoyed Schakolad Chocolate Factory's cascading chocolate fountain and Miami, sampling savory snacks and tantalizing treats from Miami's finest marshmallow lollipops, CrepeMaker's dessert crepes, The Melting Pot's chocolate restaurants, plus a rainbow's spectrum of beverages and spirits. The trendy fondue with strawberries, Key lime crème brulee from North One 10, and much more. soiree raised more than $161,000 for the DRI. Other restaurants making scrumptious contributions were: 3030 Ocean Standing in the center of the room, a large, handsome, oak bar, courtesy Restaurant, Bizcaya Grill at the Ritz Carlton in Coconut Grove, Cacao Restaurant, of ME Production, became a gathering of the evening as many guests, Café Ragazzi, Carltons Restaurant & Lounge, Joanna's Marketplace, including Honoree Joey Krutel, enjoyed chilled martinis. Oohs and ahs LaEstanciaArgentina, Mario the Baker, Neomi's Grill at the Trump International escaped the mouths of attendees who tasted the shrimp and jasmine rice Sonesta, PAUL Bakery & Café, Shulas Steak House at the Alexander Hotel, Sushi dumplings with green apple curry created especially for the event and served House, Sushi Republic, The Forge, Timo, and Touch. up by Chef Chair Michael Bloise of Wish. Both Krutel and Bloise committed New friends cozied up together on white love seats in the posh VIP lounge, themselves to the Diabetes Research Institute after losing their fathers to sponsored by Rand Eye Institute, where hors d'oeuvres were passed and champagne flutes bubbled over. VIPs were also treated to: a special silent auction, containing ultra-fabulous prizes; a huge, martini-shaped, icy luge dispensing espresso-flavored Van Gogh vodka; Daquiri Dog's frozen margarita machines; The Boutique Kitchen's West Indian style fish cakes with roasted pepper sambal; and more. Live music by The Fit seduced movers and shakers onto the dance floor, and more than 200 exciting silent auction prizes, including several luxurious vacation and local entertainment packages, plus the best of fashion, sports, art and more, spurred exhilarating bidding wars. Chairpersons Barbara Amoils, David Walker, Andy and Judy Waks, and Randy 1. 2. 3. Furshman offered special thanks to top sponsors including: Wine Spectator, Rand 1) (l-r) Co-chairpersons David Walker, Barbara Amoils, and Andy Waks Eye Institute, Southern Wine & Spirits of South Florida, Premier Beverage Company, celebrated another year of success. 2) Chef Chair Michael Bloise of Wish, shown National Distributing Company, Dr. Floyd and Jacci Seskin, FlosUSA, Comcast, with his son, Christopher, passionately pledged his dedication to the cause. Love 94, The Miami Herald, Crown Wine & Spirits, Van Gogh Vodka, Carnival 3) Joey Krutel was the center of attention as the 2006 honoree. Cruise Lines, Biorep Technologies and Franz Franc Design Group.

11 New Vitazest® Partners with the DRI

VitaZest offers nine delicious flavors.

The Diabetes Research Institute Foundation other sugary soft drinks over the last four decades has www.drinkvitazest.com, which offers an added and VitaZest® Vitamin & Fruit Enriched Water®, a greatly contributed to excessive weight gain. The benefit. Internet shoppers can get $10 off their product of Triple A Products, LLC, have teamed up researchers contend that an extra can of soda a day initial purchase of a single case of VitaZest by to help consumers quickly identify a healthful and can add up to 15 pounds in a single year. entering discount code DRIF10 at checkout. The great tasting source of hydration. VitaZest contains "With the recent news that beverages with 24-bottle assortment usually retails for $41.99 10 vitamins and minerals, no carbohydrates, no high sugar content, especially sodas, are contributing per case so the initial case price for DIRF customers calories, no sugar, no caffeine, and no preservatives. to the obesity problem in America, VitaZest Vitamin is $31.99. Customers' future purchases of VitaZest Even better, a portion of the proceeds of all VitaZest & Fruit Enriched Water offers a healthier alternative will also be discounted by $2 per case when used sales will support the Diabetes Research Institute. for hydration. Because it contains no carbohydrates with the special Diabetes Research Institute The DRI logo will be printed on all VitaZest and no sugar, this flavored beverage is a better Foundation code, DRIF. When customers place an product packaging in the Vitamin & Fruit Enriched option for those that need to be careful about their online order by the case using the special discount line of waters and other materials to indicate the carbohydrate and caloric intake," said Luigi code, the organization will receive an additional company's commitment to supporting the Meneghini, M.D., Associate Professor of Clinical contribution. Shoppers can find the discount cure-focused work being conducted at the DRI. Medicine, and Director, Eleanor and Joseph Kosow code on the Diabetes Research Institute's website, The appearance of the DRI logo will immediately Diabetes Treatment Center at the DRI. www.diabetesresearch.org. alert consumers, such as those who have diabetes “We are grateful to VitaZest for their support “We couldn't be more proud of an affiliation or who are at risk of developing diabetes, that of our mission to cure this disease and for their with a leader like the Diabetes Research Institute VitaZest is a healthy and enjoyable option. concern for all people affected by diabetes,” said and its Foundation, and we'll do all we can to The partnership between VitaZest and the DRI Robert A. Pearlman, president and CEO of the support their efforts to find a cure,” said Ziv Alcalay, Foundation has been formed at a time when the Diabetes Research Institute Foundation. “This VitaZest Vice President of Operations. “We look incidence of diabetes and obesity continues to rise partnership is a natural fit for our organization, and we forward to attending and working with the DRIF at exponentially in this country. According to a study are looking forward to a very successful relationship.” their events, with their donors and through whatever published in August by the Harvard School of Public Consumers can purchase VitaZest at various channels we can to make sure awareness is Health in the American Journal of Clinical Nutrition, retail outlets across the country, or they can order raised about the fact that VitaZest is a good choice Americans' increased consumption of soda and directly from the company's website at for consumers, especially those with diabetes.”

Support our Work While Doing Yours Honor a Loved One Through the DRIF

One of the easiest ways you can Looking for a unique way to show that you care? the DRI in continuing its important work is When you make an honor/memory gift in support of to become a Workplace Ambassador. Simply the DRI, you will conveniently: encourage your co-workers to contribute via • Honor the accomplishments of friends, family, your workplace giving campaign! These gifts and loved ones. are tax deductible and can be made through • Celebrate birthdays, anniversaries, milestones, a payroll deduction program. or holidays. For participants in the Combined Federal • Demonstrate your philanthropic support to business Campaign (CFC), please note that the DRI's associates and clients. number is 9505. We are also listed under the • Keep the memory of your loved ones alive. Health 1st America's Charities Federation. When the DRI Foundation receives an honor or To learn more about how you can help, memory gift, the individuals or family members in call 1-800-321-3437 or send an email to whose name the contribution was made are [email protected]. immediately notified, and in addition, you will receive a #9505 confirmation from the DRI Foundation acknowledging your thoughtful and generous donation.

12 In Memory of Robert T. Held, Sr.

Many of those connected to the Diabetes Research Institute and Foundation have come to think of each other as members of an extended family. In times of sorrow, it's family that pulls us through, comforting our grief, refreshing fond memories and reminding us of happier days to come. It is with great sadness that the entire DRI family mourns the loss of Robert T. Held, Sr., who passed away peacefully this past May at the age of 88. Though words cannot aptly honor him, we celebrate his life, his generosity, and his commitment to family. Bob was one of the DRI's longtime champions and was involved with the organization since its earliest days in the 1970s. In addition to bringing a number of opportunities to the organization and being involved with several fundraising events, Bob helped establish the first chair in the history of the University of Miami's Department of Medicine. In 1981, he endowed the Mary Lou Held Chair for Diabetes Research, named for his daughter-in-law who has diabetes. He also served the DRI Foundation as Chairman of the Board of Governors, was a member of the Foundation’s Governors’ Society, and later, the Honorary Board of Directors. Bob's philanthropic spirit seemed to know no bounds, and the DRI was only one of his many charitable interests. The Held Family requested that contributions in Bob Held's memory help perpetuate his hope and efforts to find a cure for diabetes. To do so, please call 1-800-321-3437 or visit www.diabetesresearch.org. Robert T. Held, Sr.

The Tax Free IRA Rollover Jeffrey Young to Chair is Finally Here! CPA Conference

On August 17, 2006, President Bush DRI Foundation Chief Financial Officer Jeffrey signed in to law, the highly anticipated Pension Young has been selected to chair the 2007 Florida Protection Act of 2006. This legislation permits CPA Not-for-Profit Organization Conference, an annual individuals over the age of 70 1/2 to make symposium that takes place in Ft. Lauderdale and charitable gifts through their IRAs without Tampa in June, and is attended by more than 250 including the amount of the gift as part of their certified public accountants from around the state. He gross income. It doesn’t, however, provide a and his committee are charged with planning, directing charitable income-tax deduction. and administering the conference in accordance with Florida Institute of Certified Public Accountants (FICPA) To qualify: policies and to comment on accounting, auditing and • The donor must be past 70 1/2 years regulatory reporting requirements in the not-for-profit arena. of age and own a traditional or Roth IRA. Adept in this particular realm of financial oversight, • The gift must be transferred directly from Jeff has also been appointed to the FICPA Executive the IRA trustee to a qualified charity. If the Jeffrey Young Committee's Not-for-Proft task force, whose objective funds are withdrawn by the IRA owner and is to enhance the effectiveness of CPAs who serve then contributed to the charity, the amount as employees or volunteers for non-profit organizations. The committee seeks to encourage and train withdrawn will be included as part of the certified public accountants to serve on organizations' boards and create vehicles for non-profits to donors gross income. find CPAs willing to serve and volunteer. • IRA gifts cannot exceed $100,000 per Since joining the Foundation in 1994, Jeff and his department have helped the Foundation's year and can be made in 2006 and 2007. financial operations run smoothly, particularly in light of the organization's tremendous growth. This • Gifts cannot be made to charitable past year, he and Oneida Osuna, accounting assistant, have processed almost 18,000 transactions, up remainder trusts or other life income gift from just over 6,000 in 1995. Nicole Washington has just joined his staff as data entry clerk, and arrangements. Nor can they be made to will be assisting with the growing responsibilities. private foundations, donor advised funds, Before coming to the DRI, Jeff previously served as controller for an ophthalmic diagnostics or supporting organizations. company in Boca Raton. He is a certified public accountant in the State of Florida and a member of the To learn more about making a gift with American Institute of CPAs. He recently published an article titled, “CA$H FLOW - Why Having GAAP your IRA, please contact Jill Shapiro Miller, DRIF Income Doesn't Necessarily Mean You Can Pay Your Bills If You Are An NPO," in the March/April 2006 Director of Gift Planning at 1-800-321-3437. issue of Florida CPA Today.

13 REVELING IN THE RED CARPET TREATMENT Craig and Sharon Silver, DRIF's Robert A. Pearlman, and Jill Viner posed with Patti LaBelle after her performance.

On the eve of the Emmy Awards, another red carpet was rolled Robert A. Pearlman of the DRI Foundation took the stage, out for An Evening Under the Stars with Patti LaBelle, a lavish affair as well, to recognize the Viners and address the audience. held at the beachside home of Jill Viner and Cliff Viner to raise “Diabetes is growing at an epidemic proportion, but what we support and awareness for the DRI. Three hundred residents and have discovered through our research is that the disease can be guests of the Hamptons enjoyed the exclusive soiree in Quogue on reversed. In fact, two people with us today have undergone islet cell Saturday, August 26. Miami-based event virtuoso Barton G. Weiss transplants and are now living insulin-free,” he said. of Barton G. transformed the magnificent private residence into the While eagerly awaiting LaBelle's arrival, guests received the ultimate social scene and concert venue. ultimate red carpet treatment. Welcoming doors swept open to greet “We are all bestowed blessings,” the lovely LaBelle began, guests with silver platters of wine. Intimate and flower bedecked explaining her connection to the event's cause. “I have diabetes; tables offered a cozy place to sit and talk, while savory food beckoned it does not have me.” from every side of the exquisite back deck, all of which was surrounded LaBelle has lived with diabetes for more than a decade, and by a breathtaking ocean view. she also lost her mother to complications of the disease. With passion Specially formulated by Barton G. for a diabetes-conscious in her voice, this performance was awe-inspiring. While standing on a audience, the menu was distinctly delicious. Protein-based “im-pasta” stage constructed atop the swimming pool, she sang favorites such as was made from chicken, shrimp and lobster. Seafood cocktails were Lady Marmalade, New Attitude, If Only You Knew, Over the Rainbow, made to order with giant shrimp, lobster tails, king crab, blue crab and On My Own, among others. Although LaBelle's tearful ballads and a choice of sauces. Lamb chops, steak and chicken were and upbeat dance tunes were one of the evening's highlights, it was grilled to perfection upon request, and tuna, salmon and scallops the powerful words of the event’s hostess that truly took center stage. were dished out generously. The Nitro-tini Bar was busy all night, “Three words led me here: My Brother as peach, grapefruit and dirty martinis were served up with floaters Craig,” said hostess Jill Viner, referring to of vodka frozen into cubes using liquid nitrogen. As the cubes Craig Silver, who has had type 1 diabetes melted, the cocktails strengthened with each sip. since he was a child. She continued, “The Not only was this event the debut for “nitrogen-fueled martinis,” advances at the Diabetes Research Institute but it also served as the unveiling of Barton G.'s new line of sugar-free have been great, but we still need to help desserts. Including everything from double fudge brownies and DRI scientists find a cure.” cheesecake lollipops to an array of ice cream and sorbet, the desserts Jill then presented an award of appreci- were so seductively sweet that guests refused to believe they were ation to Barton G. “You are not only a life- all sugar-free. time friend of mine, but also that of the After pleasing their palates, lounging in the lap of luxury and DRI,” she said. experiencing the intense performance of Patti LaBelle, guests departed via the red carpet, feeling as ultra-fabulous as an Emmy Award winner. Barton G. Weiss of Barton G. provided fabulous décor and a creative menu designed to be diabetes-friendly.

Hosts of the extravagant affair, Cliff and Jill Viner, paused for a family moment LaBelle performed on a specially constructed stage over the pool. with their daughters, Elyse (left center) and Amanda (right center).

14 BUILDING MILESTONES

Celebrating a milestone anniversary, more than 30,000 members of the Building and Construction Trades Department put down their sheet metal, set aside their hammers, and held out their hard hats for a good cause. In hundreds of cities across all 50 states, they spent a day building bridges of a different sort, spanning the gap between those suffering with diabetes and the cure. Since 1986, labor union workers, along with their families and friends, have been collecting donations for the DRI with their Dollars Against Diabetes (DAD's Day) campaign. Officially recognized on the day before Father's Day, this longstanding tradition commemorated its 20th anniversary this year with collective proceeds surpassing the $19 million mark on June 17. DAD's Day is the largest single-day fundraising campaign for diabetes research. Governors, senators and even US presidents have recognized the program as one of the top private sector initiatives in the United States. Aside from the traditional street corner collections, the campaign has grown to include events featuring a wide variety of popular hobbies. International Union of Bricklayers and Allied Craftworkers This year, more than 50 golf tournaments took place nationwide. Held by Executive Vice President Gerald O'Malley, right, presented Joe Linehan of Union Labor Life Insurance Company with the 2006 IBEW Local 26 and led by Business Manager Chuck Graham, the largest golf Championship Trophy at the 6th Annual Building Trades Softball tournament hosted 600 participants on five courses. Motorcycle enthusiasts led Slam, held Saturday, August 26 at the National Labor College in by Jay Mummy of IBEW Local 153 and Steve Hardy of Ironworkers Local 5 achieved Silver Spring, Maryland. success again with their Poker Runs. Thanks to the leadership of General President John Flynn, the Bricklayers International 6th Annual Softball Slam raised more than $100,000. And Sam Davis and the Parkersburg-Marietta Building Trades held their 3rd Annual DAD's Day Fun Shoot. Along with an annual gin rummy and golf tournament called the Labor of Love, DAD's Day is a cornerstone of Blueprint for Cure, an umbrella program of annual events spear- headed by the Building and Construction Trades Department and endorsed by the American Federation of Labor-Congress of Industrial Organizations, commonly known as AFL-CIO. This unique program began in 1984 when representatives from building trades met with the DRI Foundation and learned from parents there about the need for a research and treatment facility to lead the way toward a cure for diabetes. It reached a major milestone when the men and women of the unions funded and built the Diabetes Research Institute facility in Miami, the most comprehensive diabetes research facility in the world. The building Motorcyclists prepared to depart at the Ironworkers opened in 1994. Union workers have now raised more than $35 million to support the DRI Local 5 Poker Run in Maryland. and its research projects.

In recognition of the union's unparalleled support, a permanent plaque erected at the DRI's entrance bears the following statement: “Built by the hearts and hands of America's workers, whose generosity and craftsmanship knows no bounds.” To the thousands of people involved with DAD's Day and Blueprint for Cure today and throughout the past 20 years, the DRI extends its genuine appreciation. The milestones we have reached together over the years are invaluable.

Members of the Parkersburg Marietta Building and Construction Trades Council AFL-CIO had a blast at their annual skeet shoot.

15 EVENTS Northeast

COCKTAILS IN CONNECTICUT

The fourth Northeast outreach cocktail reception was not only held for new friends of the DRI, but also by one. Betsy Sorrel (center), whose 16-year-old son, Robbie, has type 1 diabetes, hosted the intimate affair at her home in Greenwich on April 6. Many of the 60 guests were cur- rent members of Betsy's support group for parents of children with dia- betes. Hors d'oeuvres and cocktails were passed while the DRI's Dr. Norma S. Kenyon (left) discussed the latest scientific advancements in diabetes research. Then, Betsy, along with Erica Newman, spoke about their experiences as mothers of children with diabetes. (Also pictured: DRIF's Robert A. Pearlman.)

FOUR HANDS, ONE CAUSE

On August 4, 19-year-old pianists and composers Jason Kram Yeager (2nd from right) and Ben Stepner presented Four Hands for a Cure, a unique and original jazz performance followed by a wine and cheese reception, sponsored by M. Steinert & Sons. The duo performed 12 songs for a full-house at downtown Boston's Steinert Hall, adding nearly $5,000 to The Jason Fund, which Jason's grandparents, Elly (center) and Harvey Kram (far right), started after his diagnosis with type 1 diabetes seven years ago. The extraordinary 90-minute ensemble, including the works of leading musicians, as well as that of Jason and Ben themselves, drew a standing ovation. (Also pictured: Jason's parents Peter Yeager, Kathy Kram.)

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Florida UNCORKING THE CURE On October 14, the Key Biscayne Rotary Club sponsored the 2nd Annual Key Biscayne Wine Tasting at the Sonesta Beach Resort. Guests sampled tastes from the world's finest wineries and nibbled on gourmet delicacies while mingling with the DRIF’s Robert A. Pearlman, Elina Linetsky of the DRI, islet transplant recipient Jon Hedrich, and Raul de Molina (AKA “El Gordo” of Spanish TV's “El Gordo y La Flaca”), among others. Pictured: Key Biscayne rotary club members (l-r) Angela O’Campo, Maggie and Ruben Weisson, President Bonnie Cooper, and Norm Roberts (far right) with the DRIF's Natasha Norris.

TAKING HOME A HARLEY During the 34th annual Phil Peterson’s Key West Poker Run, sponsored by Peterson’s Harley- Davidson of Miami and Harley-Davidson South, motorcycle enthusiasts enjoyed a scenic trek from Miami to Key West along US 1. Key West’s famous Duval Street was closed to outside traffic for weekend revelers, who enjoyed the carnival-like atmosphere, live music, food and drinks. Several activities kept visitors busy throughout the weekend of September 15-17, including a custom bike show, a hog roast, a bikini bike wash, plus contests judging wing- eating, beer guts and tattoos, and much, much more! Riders stopped at five designated locations along the way to draw what they hoped would be a winning poker hand. The players with the best five hands won cash, and they, along with the players with the next five best hands, competed in a game of Texas Hold ‘Em. The winner, Butch Knapp of Marathon, took home a brand new Harley Davidson Sportster! Pictured: Phil Peterson (dressed in white) celebrated another successful Poker Run with his sons, Drew (left) and Dirk (far right), plus DRIF’s Brian Huether, who was happy to accept nearly $45,000 for the DRI.

PAR FOR 23

Former Miami Dolphin quarterback and current head coach of the F.I.U. Golden Panthers Don Strock joined forces with the local produce industry for the 23rd annual Don Strock Diabetes Classic held at Miccosukee Golf & Country Club on May 18. Presented by the Miami Seaquarium, the tournament is one of South Florida's longest run- ning celebrity/amateur charity golf tournaments. Past and present NFL players who joined Strock on the course this year included Bruce Hardy, Don McNeal, Nat Moore, Kerry Glenn, Uwe Von Schamann, Madre Hill, and Bob Brudzinski. After cocktails and dinner, an awards ceremony fol- Standing (l-r): Bruce Fishbein, The Produce Connection; Bruce Schumin, M & R Produce Distributors; Arthur lowed, during which 12-year-old Karen Ripoll and Hertz, Miami Seaquarium; Gary James, Southern Specialties; Don Strock; Jerry Share and Robert Piper, Sheds Plus; Chris Fries, The Produce Connection; and John Marini, Heineken USA. Sitting (l-r): Felix Hernandex, her mother, Teresa, spoke of a day in the life of Coca-Cola; Rey Martinez, Crystal Springs; Doug Tannehill, C.H. Robinson Worldwide, Inc.; Terry Willie, the Ripoll family. Karen was diagnosed with type Miccosukee Tribe of Indians of Florida; Joe Kettinger, Outback Steakhouse; and Sean White, Minuteman 1 at age 7. The event raised an estimated Press of Boca Raton. Not pictured: A-One-A Produce and Dairy, Six L's Packing Company, American Fruit & $175,000, thanks to the committee's dedication Produce Corp., Top Tomato Company, The Oppenheimer Group, Florida Mushroom, Freedom Fresh, Sunkist Growers, Sierra Produce, Dole, Riverside Fruit & Vegetables, Fresh Quest, Warren Henry Automobiles, Inc., and the generosity of the sponsors (pictured). Bluestar Jets and Von Kantor Photography & Design.

17 EVENTS Long Island

LANIE LIVES ON

The family of Helaine Shari White continues to celebrate her incredible love of life and powerful spirit with fundraising efforts that focus on laughter, fun and family. Her parents, Rhoda (third from left) and Donald White (far right), and her two sisters and brothers-in-law, Peter and Hillari Boritz (left with newborn daughter, Rebecca) and Renee and Ron Spiegel (middle back), organized the sixth annual Lanie's Lanes at the East Meadow Bowling Lanes on March 5. More than 100 people turned out, raising nearly $30,000 for the DRI. Also pictured are Sami, Brittney and Marc Spiegel and Harrison Boritz. On May 7, Lanie's family participated in the 29th annual Five Boro Bike Tour, the largest recreational cycling event in the U.S. The 42-mile, traffic-free ride through the streets, highways and bridges of New York City attracted 30,000 participants, but the White family organized its own group of 40 cyclists, who garnered pledges from friends and family and rode in loving memory of Lanie. After the ride, the group enjoyed a celebratory picnic. The White, Boritz and Spiegel families would like to offer special thanks to all the generous individuals and companies that supported their efforts, including AM SKIER, Elmwood Day Camp, Real Data Management, and Custom Concentrates, among others. THANKS A MILLION

Held on May 4 at Jericho Terrace in Mineola, NY, Children's Best Hope for a Cure featured silent and live auctions, cocktails, dinner, and a delightful program highlighted by 13-year-old Lauren Bongiorno's rendition of “God Bless America.” Lauren's diagnosis with type 1 diabetes at age 7 gave her parents the motivation to start this fundraiser five years ago. This year, her father, Peter Bongiorno (far right), served as Honoree, while her mother, Michele Bongiorno, emceed. The affair's cumulative proceeds reached nearly $1.5 million thanks to the dedication of several Long Island philanthropists, such as Co-chairs Maggie and Michael F. Greco (2nd from right), 2003 Honoree Steven J. Eisman (far left), 2002 Honoree James Ciocia (2nd from left), 2005 Honoree Carole Enisman (center), and 400 generous attendees.

SERVING UP 30 YEARS OF SUCCESS

The 30th annual South Shore Sweethearts Tennis Tournament attracted more than 300 tennis fans to Sportime at Atlantic Beach Tennis Club, during the week of July 8-16. Led by Co-chairpersons Bob Zuckerman and Susan Miller, the event featured 14 divisions, including men's pro/am, women's round robin, and mixed doubles. Jerry (far left) and David Miller (left), winners of the first ever parent-child doubles contest, are pictured with the competition, Brett Votano (right) and Steve Goldberg (far right). Raising more than $136,000, this anniversary event was as successful as ever.

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DEDICATED TO A FRIEND OF THE DRI

On August 7, Muttontown Country Club and Pine Hollow Country Club were sold out for the annual Rod Gilbert DRI Golf Classic in East Norwich, NY. With many New York Rangers' fans in attendance, Rod Gilbert's presence was aptly appreciated, but a very special dedication gave the event even more meaning. The tournament was held in memory of Anthony John Vitale, a friend of the DRI who had diabetes for 25 years, and its proceeds were used to establish a grant in his name at the DRI. Members of the Vitale family, including Anthony J. Vitale, Jr. (right, shown with Gilbert), have been actively participating in this event for 10 years. Their extra involvement this year garnered not only profits surpassing that of last year, but also the participation and support of family friend Senator Alfonso D'Amato. The event wrapped up with dinner and an awards presentation, plus silent and live auctions, raising approximately $300,000.

What Not to Wear at Fall Into Fashion

Unsure of what not to wear? Find out at the ninth annual Fall Into Fashion luncheon, slated for 10:30 a.m. on Thursday, December 7 at the Pine Hollow Country Club in East Norwich, NY, where attendees might get an earful from one of TV's most prominent fashion mavens. Clinton Kelly, the always fashionably correct host of TLC's “What Not to Wear,” will appear at the event, where sweepstake participants will have an exclusive opportunity to win a shopping experience with Kelly's expert styling advice and honest observations. The luncheon will also feature a sumptuous brunch, an exclusive shopping environment, and unique demonstrations - from cake decorating and coffee sampling to make-up application and massage. Don't miss a chance to shop To join Co-chairs Miriam Shiff and Addy Fritzhand and Honorary Chairman Fran Helfant at the 2006 with Clinton Kelly at Lonny's event, purchase tickets online at www.diabetesresearch.org or call the DRI Foundation's Long Island and Steven Dann of Great Neck. office at 516.621.8804 or email [email protected].

California COMING UP : STAND UP!

Boasting a hilarious line-up, including host Jim Turner and headliner Dana Gould, with additional laughs supplied by Greg Behrendt and Andy Kindler, Stand Up for a Cure will be held at The Improv in Los Angeles on Sunday, November 12 at 5:30 p.m. Presented by Turner Construction Company, the fourth annual 1. 2. 3. event will feature sidesplitting comedic performances, plus a cocktail reception, dinner, a live auction, and fantastic prize drawings - from spa packages to awesome getaways. For tickets and sponsorship opportunities, call the DRI Foundation’s Los Angeles office, 323-857-0080. For more information about the event, visit www.standupforacure.org.

1) Jim Turner; 2) Dana Gould; 3) Greg Behrendt;

4) Andy Kindler 4.

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For information on the events or to make reservations, Calendar please call one of the DRI Foundation offices listed below. DRIfocus Stand Up For A Cure California Palm Beach Auxiliary Luncheon Florida is a publication of the November 12, 2006 February 12, 2007 Diabetes Research Institute Foundation. It will be another hilarious Night at the Improv when This delightful luncheon, to be held at the Polo Club Fall 2006 / Volume 35, Issue 1 a host of colorful comedians take the stage for this in Boca Raton, will feature boutique shopping and a newly renamed annual event. card party. Editor Lori Weintraub, APR Circle of Champions Charity Brunch Florida Love and Hope Ball Florida Contributors November 12, 2006 February 17, 2007 Laurie Cummings Olympian Gary Hall, Jr. will host a Sunday brunch to be To be held at the Westin Diplomat Resort & Spa in Cathryn Greene-Zavertnik held at South Beach's world famous Joe's Stone Crab, Hollywood, this extraordinary affair is certain to Natasha Norris where the afternoon's honoree, former NBA center Chris delight and surprise its guests while commemorating Lauren Schreier Dudley, will be inducted into the Circle of Champions. 33 years of success. Mitra Zehtab, M.D.

DRI Harold Kart Golf Classic Florida Diabetes Research Institute Week Florida Design November 13, 2006 February, 2007 Franz Franc Design Group Inc. An afternoon of golf followed by a cocktail reception and Volunteers will take to the streets during this weeklong Photography awards dinner will take place at Boca West Country Club. event to solicit contributions for the DRI. Students Francisco Gonzalez will conduct walkathons at Broward-area parks, and Marc S. Levine Photography Empire Ball New York other fundraising projects are encouraged, such as Von Kantor Photography & Design December 6, 2006 dress down days, letter writing campaigns, and car Claude Zick New York's Real Estate Division will gather at the washes, among others. Foundation Staff & Volunteers Grand Hyatt Hotel for this elegant, black-tie affair. Carnival for a Cure New York The Diabetes Research Institute Foundation supports the Love and Hope Preview Party Florida March 11, 2007 Diabetes Research Institute at the University of Miami Leonard December 7, 2006 Enjoy games, fun foods, great activities and more at M. Miller School of Medicine, whose mission is to develop and rapidly apply the most promising research to treat and cure Often referred to as “the heart of Love and Hope,” this family-oriented afternoon event at the this fabulous dinner reception will officially kick off those now living with diabetes. To obtain additional information Metropolitan Pavilion. or request copies of DRIfocus, please call (800) 321-3437 or the group's fundraising season at the Diplomat e-mail [email protected], or visit www.diabetesresearch.org. Country Club in Hallandale. DRI Golf Classic California April 23, 2007 Diabetes Research Institute Foundation Fall Into Fashion Long Island To be held at El Caballero Country Club, the third National Office December 7, 2006 annual tournament will feature an afternoon of golf, 3440 Hollywood Boulevard, Suite 100. Hollywood, FL 33021 Set to the theme of “Friends Celebrating Friends,” this followed by a dinner and awards ceremony. Phone: (954) 964-4040 Fax: (954) 964-7036 fashionable brunch will be held at the Pine Hollow [email protected] Country Club in East Norwich and feature a unique Crystal Ball Long Island shopping experience, auctions, an appearance by May 7, 2007 Northeast Regional Office 381 Park Avenue South, Suite 1118, New York, NY 10016 TLC's Clinton Kelly, and more. This black-tie gala at the Garden City Hotel will Phone: (212) 888-2217 Fax: (212) 888-2219 feature cocktails, dinner, dancing, auctions and [email protected] Pleasures of the Palate Florida live entertainment. January 22, 2007 Long Island Regional Office To be held at NORMAN'S in Coral Gables, guests will Shell Key West Challenge Florida 45 Glen Cove Road. Greenvale, NY 11548 enjoy a sumptuous five-course meal paired with wines May 17-21, 2007 Phone: (516) 621-8804 Fax: (516) 621-8501 from around the world, plus live and silent auctions. For more than two decades, this five-day fishing [email protected] tournament, sponsored by Shell Oil, has been a Key DRI Golf and Tennis Classic Florida California Regional Office West tradition. For the first time, the 2007 event 6624 Melrose Avenue. Los Angeles, CA 90038 January 29, 2007 will benefit the DRI. An afternoon of golf and tennis tournaments at Phone: (323) 857-0080 Fax: (323) 857-1856 [email protected] La Gorce Country Club in Miami Beach will be followed by a cocktail reception and awards dinner.

Non-Profit DRIfocus US Postage Diabetes Research Institute PAID National Foundation Office Diabetes Research 3440 Hollywood Blvd. Institute Foundation Suite 100 Hollywood, FL 33021 www.diabetesresearch.org address service requested