The United Mitochondrial Disease Foundation is proud to present... Mitochondrial Medicine 2018: Nashville MITOCHONDRIAL MEDICINE 2018 Mitochondrial Chemical Biology Sheraton Music City Nashville, TN Scientific Meetings: June 27 - 30, 2018 2018 Course Chair: Vamsi K. Mootha, MD 2018 CME Chair: Bruce H. Cohen, MD A special thanks to those organizations serving on the Planning Commitee: Akron Children’s Hospital, the Mitochondrial Medicine Society, and the Mitochondria Research Society Mitochondrial Medicine 2018: Nashville Scientific Program June 27 - 30, 2018 Mitochondrial Medicine 2018: Nashville 2018 Course Description The United Mitochondrial Disease Foundation and Children’s Hospital Medical Center of Akron (CHMCA) have joined efforts to sponsor and organize a CME-accredited national symposium. Mitochondrial diseases are more common than previously recognized and mitochondrial pathophysiology is now a recognized part of many disease processes, including heart disease, cancer, AIDS and diabetes. There have been significant advances in the molecular genetics, proteomics, epidemiology and clinical aspects of mitochondrial pathophysiology. This conference is directed toward the scientist and clinician interested in all aspects of mitochondrial science. The content of this educational program was determined by rigorous assessment of educational needs and includes surveys, program feedback, expert faculty assessment, literature review, medical practice, chart review and new medical knowledge. The format will include didactic lectures from invited experts intermixed with peer-reviewed platform presentations. There will be ample time for professional discussion both in and out of the meeting room, and peer-reviewed poster presentations will be given throughout the meeting. This will be a four-day scientific meeting aimed at those with scientific and clinical interests. Learning Objectives At the end of the scientific program, attendees will: • Learn about newly characterized mitochondrial enzymes. • Become familiar with new insights into mitochondrial redox biochemistry and how this may be applied to developing new therapies for mitochondrial diseases. • Learn how mitochondrial dysfunction affects the metabolic profile. • Discover how imagining mass spectrometry can be used to understand mitochondrial function. • Summarize how drugs can be developed that target them to the mitochondria. • Describe the efforts of drug repurposing and how old medications may result in mitochondrial therapeutics. • List the new developments in clinical trials in mitochondrial disease and distinguish the differences in their mechanisms of action. • Demonstrate how the mitochondria can serve as an undesired target of pharmaceuticals and environmental exposures. Mitochondrial Medicine 2018: Nashville Credits The Children’s Hospital Medical Center of Akron designates this live activity for a maximum of 19.75 AMA PRA Category I CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Accreditation Statement This activity has been planned and implemented in accordance with the accreditation requirements and poli- cies of the Ohio State Medical Association (OSMA) through the joint providership of Children’s Hospital Medical Center of Akron and The United Mitochondrial Disease Foundation. The Children’s Hospital Medical Center of Akron is accredited by the OSMA to provide continuing medical education for physicians. Special Announcements Name Badges All attendees must wear a name badge to all course functions. Scientific Sessions All scientific sessions will be held in Hermitage ABC. Refreshment Breaks Exhibits will be open in the Hermitage Lobby during all breaks and lunches. Posters will be in Two Rivers/ Kingsley Rooms. All posters are assigned numbers in the back of this syllabus. Presenters will station themselves at their poster to field questions according to those numbers as follows: even numbers on Wednesday from 5:30 pm to 7:30 pm and odd numbers on Thursday from 5:45 pm to 7:45 pm. Meals Continental Breakfasts and Lunches will be held in Hermitage DE. Friday Night Banquet and Awards Ceremony Scientific and family program attendees are invited to attend the Friday Night Banquet and Award Ceremony in the Heritage Ballroom. CME Verification Form Physicians: All physicians were given a 3-part CME Verification Form at Registration. Fully complete, sign, and turn in the carbon copy of the form to the registration desk at the end of the meeting (or upon your departure if you will not be staying for the duration of the meeting). Keep the WHITE copy for your records. Non-Physicians: All non-physicians were given a 3-part Verification Form at registration. Fully complete, sign, and turn in the carbon copies of the form at the end of the meeting (or upon your departure if you will not be staying for the duration of the meeting). Keep the WHITE copy for your records. Mitochondrial Medicine 2018: Nashville 2018 Scientific Planning Committee • Vamsi K. Mootha, MD, 2018 Course Chair • Giovanni Manfredi, MD, PhD Harvard Medical School, Boston, MA Weill Cornell Medicine, New York, NY • Bruce H. Cohen, MD, 2018 CME Chair • Robert K. Naviaux, MD, PhD Akron Children’s Hospital, Akron, OH University of California San Diego, LaJolla, CA • William Copeland, PhD • Sumit Parikh, MD NIEHS, Research Triangle Park, NC The Cleveland Clinic, Cleveland, OH • Marni Falk, MD • Russell Saneto, DO, PhD Children’s Hospital of Philadelphia, Philadelphia, PA Seattle Children’s Research Institute, Seattle, WA • Amy Goldstein, MD • Peter Stacpoole, PhD, MD Children’s Hospital of Pittsburgh, Pittsburgh, PA University of Florida, Gainesville, FL • Larry Grossman, PhD • Keshav Singh, PhD Wayne State University School of Medicine, Detroit, MI University of Alabama at Birmingham, AL • Adam Hartman, MD • Philip E. Yeske, PhD NINDS/NIH, Rockville, MD UMDF Science & Alliance Officer, Pittsburgh, PA • Amel Karaa, MD • Kara Strittmatter, CMM, MA Massachusetts General Hospital, Boston, MA UMDF Meeting Event Director, Columbus, OH • Carla Koehler, PhD University of California Los Angeles, Los Angeles, CA 2018 Abstract Presenters • Rachael Baker, PhD • Tomas Mracek, PhD Calvin College, Grand Rapids, MI Institute of Physiology CAS, Prague, Czech Republic • Emanuele Barca, MD, PhD • Derek Narendra, MD, PhD Columbia University Medical Center, New York, NY NINDS/NIH, Bethesda, MD • William Copeland, PhD • Martin Picard, PhD 2017 Course Co-Chair, NIEHS, Research Triangle Park, NC Columbia University Medical Center, New York, NY • Marilena D’Aurelio, PhD • Rocio Rius, MD, MPH, MCRI Weill Cornell Medicine, New York, NY Melbourne, Australia • Larry Grossman, PhD • Hongying Shen, PhD Wayne State University School of Medicine, Detroit, MI Massachusetts General Hospital, Boston, MA • Sujay Guha, PhD • Keshav Singh, PhD Children’s Hospital of Philadelphia, Philadelphia, PA University of Alabama at Birmingham, AL • Nahid Khan, PhD • Marketa Tesarova, PhD University of Helsinki, Helsinki, Finland Department of Pediatrics and Adolescent Medicine, Charles University, • Shannon Kruk RN, BS First Faculty of Medicine, and General University Hospital in Prague, NIH Bethesda, MD Prague, Czech Republic • Giovanni Manfredi, MD, PhD • Atif Towheed, PhD Weill Cornell Medicine, New York, NY Children’s Hospital of Philadelphia, Philadelphia, PA • Edward McKee, PhD • Jesse Wilson, PhD College of Medicine, Central Michigan University, Mt Pleasant, MI Colorado State University, Fort Collins, CO • Meagan McManus • Linlin Zhao Children’s Hospital of Philadelphia, Philadelphia, PA Central Michigan University, Mount Pleasant, MI • Bryce Mendelsohn MD, PhD • Zarazuela Zolkipli-Cunningham UCSF, San Francisco, CA Children’s Hospital of Philadelphia, PA • Carlos Moraes, PhD • Olga Zurita Rendon, PhD University of Miami, Miami, FL University of Utah, Salt Lake City, UT • Raphael Morscher, MD, PhD University Children’s Hospital Zürich, Zürich, Switzerland Mitochondrial Medicine 2018: Nashville 2018 Scientific Meeting Faculty • Vamsi K. Mootha, MD, 2018 Course Chair • Ethan Perlstein, PhD Harvard Medical School, Boston, MA CEO, Perlara, San Francisco, CA • Richard Caprioli, PhD • Pere Puigserver, PhD Vanderbilt University, Nashville, TN Dana-Farber Cancer Institute, Boston, MA • Christopher J. Chang, PhD • Jared Rutter, PhD UC Berkeley, CA University of Utah, Salt Lake City, UT • Sarah Elsea, PhD • Rohit Sharma, MD, PhD Baylor College of Medicine, Houston, TX Massachusetts General Hospital, Boston, MA • Marni Falk, MD • Gerald I. Shulman, MD, PhD Children’s Hospital of Philadelphia, PA Yale University School of Medicine, New Haven, CT • Grainne Gorman, PhD • Jan Smeitink, MD, PhD Wellcome Trust Centre for Mitochondrial Research, UK Radboud Center for Mitochondrial Medicine, Radbou- dumc, Nijmegen, The Netherlands • Michio Hirano, MD Columbia University, New York, NY • Anu Suomalainen, MD, PhD University of Helsinki, Finland • Dean P. Jones, PhD Emory University, Atlanta, GA • Tanja Taivassalo, PhD University of Florida College of Medicine, Gainesville, FL • Shana Kelley, PhD University of Toronto, Canada • Mark Tarnopolsky, MD, PhD FRCP(C) McMaster University Medical Center, Ontario, • Kiyoshi Kita, PhD Canada Nagasaki University, Japan • Alice Ting, PhD • Carla Koehler, PhD Stanford University, Stanford, CA University of California, Los Angeles, CA • Kendall B. Wallace, PhD • Daria Mochly-Rosen, PhD University of Minnesota, Duluth, MN Stanford University, Stanford, CA