ii Contents of Volume 83, 2019

CONTENTS OF VOLUME 83, 2019

Message From the Editor-in-Chief

1. Message From the Editor-in-Chief Toyoaki Murohara ········· 1 2. Editorial Statistics and Best Reviewers Award for 2018 Toyoaki Murohara ········· 249 3. Circulation Journal Awards for the Year 2018 Toyoaki Murohara ········· 495 4. Rapid Publication and Announcement of the 2019 JCS Meeting Activities Toyoaki Murohara ········· 695 5. Announcement of the 2019 JCS Meeting Activities (2) Toyoaki Murohara ········· 949 6. Message From the Editor-in-Chief Toyoaki Murohara ········· 1421 7. Message From the Editor-in-Chief Toyoaki Murohara ········· 1621 8. Message From the Editor-in-Chief Toyoaki Murohara ········· 1811

In Memoriam

1. Tribute to Dr. John Ross Jr Shigetake Sasayama ········· 1817 2. Kazuo Yamada, MD, PhD ― 1924–2019 ― Junji Toyama ········· 2189 3. Tribute to Paul M. Vanhoutte, MD, PhD ― 1940–2019 ― Hiroaki Shimokawa, Tetsuhiko Nagao, Kimihiro Komori ········· 2391

JCS Statement

1. Standard Cardiac Rehabilitation Program for Heart Failure Hideo Izawa, Toshiko Yoshida, Toshimi Ikegame, Kazuhiro P. Izawa, Yoshihiro Ito, Hideo Okamura, Naohiko Osada, Shintaro Kinugawa, Takuro Kubozono, Yuji Kono, Kiyonori Kobayashi, Kazuhiko Nishigaki, Taiki Higo, Akihiro Hirashiki, Yasushi Miyazawa, Yuji Morio, Masanobu Yanase, Sumio Yamada, Hisao Ikeda, Shin-ichi Momomura, Yasuki Kihara, Kazuhiro Yamamoto, Yoichi Goto, Shigeru Makita, the Japanese Association of Cardiac Rehabilitation Standard Cardiac Rehabilitation Program Planning Committee ········· 2394

Reviews

1. Clonal Hematopoiesis and Its Impact on Cardiovascular Disease Soichi Sano, Ying Wang, Kenneth Walsh ········· 2 2. Discovery of a Vascular Endothelial Stem Cell (VESC) Population Required for Vascular Regeneration and Tissue Maintenance Nobuyuki Takakura ········· 12 3. Ivabradine for the Treatment of Cardiovascular Diseases Tomomi Ide, Kisho Ohtani, Taiki Higo, Makoto Tanaka, Yasushi Kawasaki, Hiroyuki Tsutsui ········· 252 4. Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System Mikito Takefuji, Toyoaki Murohara ········· 261 5. ANGPTL3 Inhibitors ― Their Role in Cardiovascular Disease Through Regulation of Lipid Metabolism ― Eleni Geladari, Panagiota Tsamadia, Natalia G. Vallianou ········· 267 6. Controversies in the 2017 ACC/AHA Hypertension Guidelines: Who Can Be Eligible for Treatments Under the New Guidelines? ― An Asian Perspective ― Sang-Hyun Ihm, George Bakris, Ichiro Sakuma, Il Suk Sohn, Kwang Kon Koh ········· 504 7. Autophagy in the Heart Osamu Yamaguchi ········· 697

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8. Current Key Issues in Transcatheter Aortic Valve Replacement Undergoing a Paradigm Shift In-Chang Hwang, Kentaro Hayashida, Hyo-Soo Kim ········· 952 9. Autologous CD34+ Cell Therapy for Ischemic Tissue Repair William K. Sietsema, Atsuhiko Kawamoto, Hiroshi Takagi, Douglas W. Losordo ········· 1422 10. Immune Disorder in Atherosclerotic Cardiovascular Disease ― Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers ― Rajib Neupane, Xiongjie Jin, Takeshi Sasaki, Xiang Li, Toyoaki Murohara, Xian Wu Cheng ········· 1431 11. Utilization of Artificial Intelligence in Echocardiography Kenya Kusunose, Akihiro Haga, Takashi Abe, Masataka Sata ········· 1623 12. Nationwide Actions Against Heart Failure Pandemic in Japan ― What Should We Do From Academia? ― Issei Komuro, Hidehiro Kaneko, Hiroyuki Morita, Mitsuaki Isobe, Hirofumi Nakayama, Kazuo Minematsu, Takenori Yamaguchi, Yoshio Yazaki ········· 1819 13. Role of Advanced Glycation Endproduct (AGE)-Receptor for Advanced Glycation Endproduct (RAGE) Axis in Cardiovascular Disease and Its Therapeutic Intervention Sho-ichi Yamagishi ········· 1822 14. Strategies to Overcome Residual Risk During Statins Era Kyoung Im Cho, Jongwook Yu, Toshio Hayashi, Seung Hwan Han, Kwang Kon Koh ········· 1973 15. Effects of Tobacco Smoking on Cardiovascular Disease Takahisa Kondo, Yoshihisa Nakano, Shiro Adachi, Toyoaki Murohara ········· 1980 16. The Impending Epidemic of Cardiovascular Diseases in Patients With Cancer in Japan Yuji Okura, Kazuyuki Ozaki, Hiroshi Tanaka, Tatsuya Takenouchi, Nobuaki Sato, Tohru Minamino ········· 2191 17. Function Follows Form ― A Review of Cardiac Cell Therapy ― Kenta Nakamura, Charles E. Murry ········· 2399

Congress Reports

2018 ESC Report 1. European Society of Cardiology (ESC) Annual Congress Report From Munich 2018 Yasutsugu Shiono, Takashi Akasaka ········· 18 2019 JCS Report 2. Overview of the 83rd Annual Scientific Meeting of the Japanese Circulation Society ― Renaissance of Cardiology for the Creation of Future Medicine ― Hiroshi Akazawa, Haruhiro Toko, Mutsuo Harada, Kazutaka Ueda, Satoshi Kodera, Arihiro Kiyosue, Katsuhito Fujiu, Masaru Hatano, Masao Daimon, Jiro Ando, Eiki Takimoto, Hiroyuki Morita, Issei Komuro ········· 1829

Editorials

1. Does the Cardiac Surgeon Accept Coronary Artery Bypass Grafting With Incomplete Revascularization for Patients With Low Ventricular Function and Complex Multivessel Coronary Disease? Shinya Takase ········· 25 2. Gender Difference in the Association Between Uric Acid and Atrial Fibrillation Masanari Kuwabara, Ichiro Hisatome ········· 27 3. Altered Gut Flora and Gut Microbiome-Derived Metabolites in Heart Failure Patients in the Compensated and Decompensated Phases Akiomi Yoshihisa ········· 30 4. Heart Failure Mid-Range Ejection Fraction ― Heart Failure With Multiple Personalities ― Shin-ichi Momomura, Miyuki Ito ········· 274 5. Beneficial Prognostic Effects of Statins in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients ― HFpEF as a Manifestation of Systemic Disease ― Tatsuo Aoki ········· 277 6. Novel Echocardiographic Parameter in Heart Failure Is Born Naoyuki Yokoyama ········· 279 7. Oral β-Blocker Therapy in Acute Myocardial Infarction Neiko Ozasa, Takeshi Kimura ········· 281 8. Unexpected, But Reasonable Association Between Anderson-Fabry Disease and Coronary Vasospasm Tetsuya Matoba, Yasuhiro Nakano, Hiroyuki Tsutsui ········· 283 9. Crosstalk Between the Heart and Blood in Heart Failure Naoki Sato ········· 511

Circulation Journal Vol.83, December 2019 iv Contents of Volume 83, 2019

10. C-Reactive Protein and Chronic Inflammation ― Is It a Novel Therapeutic Target for Subsequent Cancer Death in Patients With Coronary Artery Disease? ― Hidehiro Kaneko, Issei Komuro ········· 513 11. How Is Uric Acid Related to Atrial Fibrillation? Katsushige Ono ········· 705 12. Underdosing of Direct Oral Anticoagulants ― Pros or Cons? ― Moritake Iguchi, Masaharu Akao ········· 707 13. Genetic Prediction of Atherosclerosis ― Significance of Polymorphisms in Bone Morphogenetic Protein Signaling Molecule Genes ― Mari Ishida ········· 709 14. Coffee Drinking and Risk of All-Cause Mortality and Cardiovascular Diseases Yoichiro Hirakawa ········· 711 15. Importance of Risk Stratification After Myocardial Infarction and the Need for Its Clinical Application Seung Hwan Han, Kwang Kon Koh ········· 713 16. Self-Efficacy and Physical Activity Level Holds Important Implications for Transfer of Adult Congenital Heart Disease Takashi Miyamoto ········· 715 17. A Main Performer May Come for Percutaneous Coronary Intervention With Atrial Fibrillation in Japanese Patients Ken Kozuma ········· 963 18. Years of Life Lost Analysis May Promote Governmental Policy to Prevent Atherosclerotic Cardiovascular Disease Yoshiyuki Ikeda, Mitsuru Ohishi ········· 965 19. Clinical Impact and Significance of Serum Lipoprotein (a) Levels on Cardiovascular Risk in Patients With Coronary Artery Disease Hiroshi Yoshida ········· 967 20. Triglycerides as Residual Risk for Atherosclerotic Cardiovascular Disease Hirotoshi Ohmura ········· 969 21. Low Endothelial Sheer Stress ― A Silent Killer ― Shichiro Abe, Setsu Nishino, Masashi Sakuma, Teruo Inoue ········· 1197 22. First Hospitalization Tells Us Everything About Heart Failure Shintaro Kinugawa, Arata Fukushima ········· 1200 23. Atrial Fibrillation Does Not Matter in Japanese Ventricular Assist Device Patients? ― Half-Way Up the Hill ― Toshiyuki Nagai, Toshihisa Anzai ········· 1202 24. Renin Activity as a Key Predictor of Major Adverse Cardiac Events Takahisa Kondo, Yoshihisa Nakano, Shiro Adachi, Toyoaki Murohara ········· 1204 25. Vascular Senescense and Endothelial Function ― Can We Apply It to Atrial Fibrillation? ― Toshio Hayashi ········· 1439 26. Is Working at a Small Company a Component of “The Status Syndrome” in Japan? Isao Saito ········· 1441 27. Activin A ― A Potentially Useful Biomarker of Diastolic Dysfunction ― Satoshi Masutani ········· 1443 28. Insights From 10-Year Outcomes of Mesenchymal Stem Cell Transplantation in Heart Failure Patients Oto Inoue, Masayuki Takamura ········· 1446 29. Newer Specific Risk Scores for Outcome After Transcatheter Aortic Valve Replacement Noriaki Tabata, Kenichi Tsujita ········· 1630 30. Kidney Measures to Improve Risk Discrimination of Cardiovascular Events Hideki Ishii, Toyoaki Murohara ········· 1836 31. Worsening of Left Ventricular Diastolic Function Is Associated With Adverse Outcomes in Patients With Coronary Artery Disease Satoshi Yuda ········· 1838 32. Risk Factors for Major Amputation in the Japanese Population ― How Can We Predict and Prevent Lower Limb Loss in Patients With Peripheral Arterial Disease? ― Toshifumi Kudo ········· 1840 33. You Want to See a Female Doctor ― But Unluckily There's a Lack in Japan ― Yuko Inoue, Chisato Izumi ········· 1842 34. How Do We Improve the Utility of Fractional Flow Reserve? ― For Precise Diagnosis of Myocardial Ischemia ― Hideki Ishii, Toyoaki Murohara ········· 1986 35. Exploratory “Odyssey” During Pursuit of Plaque Control Hirohiko Ando, Hiroaki Takashima, Tetsuya Amano ········· 1988 36. Effects of Heart Rate Reduction by Ivabradine for Heart Failure Beyond β-Blockers Yoshihiro Seo, Nobuyuki Ohte ········· 1991

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37. Prognostic Relevance of Discordant Results Between Fractional Flow Reserve and Resting Indices Takashi Kubo, Yasutsugu Shiono ········· 2203 38. What We Know and What We Don’t Know About the Adaptation to Pregnancy and Left Ventricular Diastolic Dysfunction Naoto Kawamatsu, Tomoko Ishizu, Yasushi Kawakami ········· 2205 39. Possible Biomarker for an Important Yet Neglected Symptom After Stroke ― Metalloproteinase-9 and Post-Stroke Depression ― Yoshinobu Wakisaka ········· 2208 40. Guidelines for Atrial Fibrillation Treatment to Avoid Stroke Should Be Established for Each Region/Ethnicity Tetsuji Shinohara, Naohiko Takahashi ········· 2413 41. What Is the Rationale for Utilizing Bilateral Internal Thoracic Arteries in Concomitant Cardiac Operations? Hirofumi Takemura ········· 2416

Late Breaking Clinical Trial (JCS 2019)

1. Long-Term Treatment With Evolocumab Among Japanese Patients ― Final Report of the OSLER Open-Label Extension Studies ― Atsushi Hirayama, Shizuya Yamashita, Andrea Ruzza, Hyoe Inomata, Marcoli Cyrille, Chen Lu, Andrew W. Hamer, Masayuki Yoshida, Arihiro Kiyosue, Tamio Teramoto ········· 971

Late Breaking Cohort Study (JCS 2019)

1. Contemporary Antiplatelet Therapy and Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction ― Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR) ― Satoshi Yasuda, Satoshi Honda, Misa Takegami, Kensaku Nishihira, Sunao Kojima, Yasuhide Asaumi, Makoto Suzuki, Masami Kosuge, Jun Takahashi, Yasuhiko Sakata, Morimasa Takayama, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura on behalf of the JAMIR Investigators ········· 1633

Original Articles

Aortic Disease (4) 1. Outcomes of Early-Onset Acute Type A Aortic Dissection ― Influence of Etiologic Factors ― Naoyuki Kimura, Kei Aizawa, Koji Kawahito, Ryo Itagaki, Atsushi Yamaguchi, Yoshio Misawa, Matthias Siepe, Martin Czerny, Friedhelm Beyersdorf, Fabian Alexander Kari, Bartosz Rylski ········· 285 2. Pregnancy-Associated Plasma Protein-A Accelerates Atherosclerosis by Regulating Reverse Cholesterol Transport and Inflammation Shi-Lin Tang, Zhen-Wang Zhao, Shang-Ming Liu, Gang Wang, Xiao-Hua Yu, Jin Zou, Si-Qi Wang, Xiao-Yan Dai, Min-Gui Fu, Xi-Long Zheng, Da-Wei Zhang, Hui Fu, Chao-Ke Tang ········· 515 3. Outcomes of Thoracic Aortic Surgery in Patients With Coronary Artery Disease ― Based on the Japan Adult Cardiovascular Surgery Database ― Masahiro Daimon, Hiroaki Miyata, Noboru Motomura, Yutaka Okita, Shinichi Takamoto, Sachiko Kanki, Takahiro Katsumata ········· 978 4. Effect of Intraoperative Division of the Left Renal Vein on the Fate of Renal Function and Left Renal Volume After Open Repair of Para- and Juxtarenal Aortic Aneurysm Masayuki Sugimoto, Noriko Takahashi, Kiyoaki Niimi, Akio Kodama, Hiroshi Banno, Kimihiro Komori ········· 1844 Arrhythmia/Electrophysiology (32) 5. Pro-Arrhythmogenic Effects of Heterogeneous Tissue Curvature ― A Suggestion for Role of Left Atrial Appendage in Atrial Fibrillation ― Jun-Seop Song, Jaehyeok Kim, Byounghyun Lim, Young-Seon Lee, Minki Hwang, Boyoung Joung, Eun Bo Shim, Hui-Nam Pak ········· 32 6. Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity Luis A. Gonano, Marisa Sepúlveda, Malena Morell, Tamara Toteff, María Florencia Racioppi, Elena Lascano, Jorge Negroni, María Julieta Fernández Ruocco, Emiliano Medei, Gabriel Neiman, Santiago G. Miriuka, Thomas G. Back, S. R. Wayne Chen, Alicia Mattiazzi, Martin Vila Petroff ········· 41 7. Current Trends in Implantable Cardioverter-Defibrillator Therapy in Children ― Results From the JCDTR Database ― Hiroko Asakai, Akihiko Shimizu, Takeshi Mitsuhashi, Takeshi Ueyama, Hisashi Yokoshiki, Nobuhiro Nishii, Yukio Sekiguchi, Hideo Okamura, Norishige Morita, Takashi Nitta, Kenzo Hirao, Members of the Implantable Cardioverter-Defibrillator (ICD) Committee of the Japanese Heart Rhythm Society ········· 52

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8. Evaluation of Need for Implantable Cardioverter-Defibrillator by Thallium-201 Scintigraphy Among Japanese Patients With Prior Myocardial Infarction Masato Okada, Kazunori Kashiwase, Akio Hirata, Mayu Nishio, Yasuharu Takeda, Takayoshi Nemoto, Ryohei Amiya, Yasunori Ueda, Yoshiharu Higuchi, Yoshio Yasumura ········· 56 9. Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan ― Insights From GARFIELD- AF ― Yukihiro Koretsune, Takuma Etoh, Yousuke Katsuda, Tetsuro Suetsugu, Kenshi Kumeda, Ichiro Sakuma, Kenichi Eshima, Mitsuhiro Shibuya, Shin-ichi Ando, Naoto Yokota, Shinya Goto, Karen S. Pieper, Jagan Allu, Ajay K. Kakkar for the GARFIELD-AF Investigators ········· 67 10. Improvement of Hemodynamic Parameters in Patients With Preserved Left Ventricular Systolic Function by Catheter Ablation of Atrial Fibrillation ― A Prospective Study Using Impedance Cardiography ― Yosuke Nakatani, Tamotsu Sakamoto, Yoshiaki Yamaguchi, Yasushi Tsujino, Naoya Kataoka, Kunihiro Nishida, Koichi Mizumaki, Koichiro Kinugawa ········· 75 11. Second-Generation Cryoballoon Ablation for Atrial Fibrillation ― A Detailed Analysis of the Impact of Left Atrial Volume Index on Clinical Outcome ― Ken Takarada, Erwin Ströker, Carlo de Asmundis, Juan Sieira, Juan-Pablo Abugattas, Hugo-Enrique Coutiño, Francesca Salghetti, Rajin Choudhury, Saverio Iacopino, Pedro Brugada, Gian-Battista Chierchia ········· 84 12. In-Hospital Electrical Storm in Acute Myocardial Infarction ― Clinical Background and Mechanism of the Electrical Instability ― Yoshinori Kobayashi, Kaoru Tanno, Akira Ueno, Seiji Fukamizu, Hiroshige Murata, Norikazu Watanabe, Takeshi Sasaki, Takeshi Yamamoto, Morimasa Takayama, Ken Nagao ········· 91 13. Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice Rajesh Prajapati, Takayuki Fujita, Kenji Suita, Takashi Nakamura, Wenqian Cai, Yuko Hidaka, Masanari Umemura, Utako Yokoyama, Björn C. Knollmann, Satoshi Okumura, Yoshihiro Ishikawa ········· 295 14. Trends and Outcome of Catheter Ablation of Atrial Fibrillation Over 9 Years ― Focus on Empirical Extra-Pulmonary Vein Ablation ― Je-Wook Park, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak ········· 304 15. Prevalence and Incidence of Atrial Fibrillation in the General Population Based on National Health Insurance Special Health Checkups ― TAMA MED Project-AF ― Eitaro Kodani, Tomohiro Kaneko, Hitomi Fujii, Hiroyuki Nakamura, Hajime Sasabe, Yutaka Tamura, Wataru Shimizu ········· 524 16. Clinical and Electrocardiographic Differences in Brugada Syndrome With Spontaneous or Drug-Induced Type 1 Electrocardiogram Tomomi Nagayama, Satoshi Nagase, Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y. Inoue, Koji Miyamoto, Takashi Noda, Takeshi Aiba, Hiroshi Takaki, Masaru Sugimachi, Wataru Shimizu, Teruo Noguchi, Satoshi Yasuda, Shiro Kamakura, Kengo Kusano ········· 532 17. Poor Quality of Warfarin Treatment Increases the Risk of All Types of Intracranial Hemorrhage in Atrial Fibrillation Paula Tiili, Jukka Putaala, Juha Mehtälä, Houssem Khanfir, Jussi Niiranen, Pasi Korhonen, Pekka Raatikainen, Mika Lehto ········· 540 18. Comparison of the Safety and Efficacy of Automated Annotation-Guided Radiofrequency Ablation and 2nd- Generation Cryoballoon Ablation in Paroxysmal Atrial Fibrillation Nobuaki Tanaka, Koji Tanaka, Yuichi Ninomiya, Yuko Hirao, Takafumi Oka, Masato Okada, Hiroyuki Inoue, Ryo Nakamaru, Kohtaro Takayasu, Ryo Kitagaki, Yasushi Koyama, Atsunori Okamura, Katsuomi Iwakura, Yasushi Sakata, Kenshi Fujii, Koichi Inoue ········· 548 19. Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes Fikri Taufiq, Nani Maharani, Peili Li, Yasutaka Kurata, Nobuhito Ikeda, Masanari Kuwabara, Naoyuki Otani, Junichiro Miake, Akira Hasegawa, Motokazu Tsuneto, Yasuaki Shirayoshi, Haruaki Ninomiya, Tatsuya Saitoh, Akira Nakai, Kazuhiro Yamamoto, Ichiro Hisatome ········· 718 20. Clinical Outcomes of Off-Label Dosing of Direct Oral Anticoagulant Therapy Among Japanese Patients With Atrial Fibrillation Identified From the SAKURA AF Registry Nobuhiro Murata, Yasuo Okumura, Katsuaki Yokoyama, Naoya Matsumoto, Eizo Tachibana, Keiichiro Kuronuma, Koji Oiwa, Michiaki Matsumoto, Toshiaki Kojima, Shoji Hanada, Kazumiki Nomoto, Ken Arima, Fumiyuki Takahashi, Tomobumi Kotani, Yukitoshi Ikeya, Seiji Fukushima, Satoru Itoh, Kunio Kondo, Masaaki Chiku, Yasumi Ohno, Motoyuki Onikura, Atsushi Hirayama for the SAKURA AF Registry Investigators ········· 727 21. Burden of Implanted-Device-Detected Atrial High-Rate Episode Is Associated With Future Heart Failure Events ― Clinical Significance of Asymptomatic Atrial Fibrillation in Patients With Implantable Cardiac Electronic Devices ― Ryo Nishinarita, Shinichi Niwano, Hidehira Fukaya, Jun Oikawa, Takeru Nabeta, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Yuki Shirakawa, Ai Horiguchi, Hironori Nakamura, Naruya Ishizue, Jun Kishihara, Akira Satoh, Junya Ako ········· 736

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22. Impact of Renal Dysfunction on Left Atrial Low-Voltage Areas in Patients With Atrial Fibrillation Yasuhiro Matsuda, Masaharu Masuda, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Shota Okuno, Aki Tsuji, Toshiaki Mano ········· 985 23. Rivaroxaban or Apixaban for Non-Valvular Atrial Fibrillation ― Efficacy and Safety of Off-Label Under-Dosing According to Plasma Concentration ― Michihiro Suwa, Isao Morii, Masaya Kino ········· 991 24. Characterization of Residual Conduction Gaps After HotBalloon-Based Antral Ablation of Atrial Fibrillation ― Evidence From Ultra-High-Resolution 3-Dimensional Mapping ― Shiro Nakahara, Yuichi Hori, Reiko Fukuda, Naoki Nishiyama, Sayuki Kobayashi, Yoshihiko Sakai, Isao Taguchi ········· 1206 25. Shorter Leukocyte Telomere Length Is Associated With Atrial Remodeling and Predicts Recurrence in Younger Patients With Paroxysmal Atrial Fibrillation After Radiofrequency Ablation Kuo-Li Pan, Ya-Wen Hsiao, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Yung-Nan Tsai, Tze-Fan Chao, Jo-Nan Liao, Chin-Yu Lin, Shih-Jie Jhuo, Chung-Hsing Lin, Allamsetty Suresh, Rohit Walia, Abigail Louise D. Te, Shinya Yamada, Yao-Ting Chang, Shih-Lin Chang, Shih-Ann Chen ········· 1449 26. Efficacy and Safety of the Ultra-Short-Acting β1-Selective Blocker Landiolol in Patients With Recurrent Hemodynamically Unstable Ventricular Tachyarrhymias ― Outcomes of J-Land II Study ― Takanori Ikeda, Tsuyoshi Shiga, Wataru Shimizu, Koichiro Kinugawa, Atsuhiro Sakamoto, Ryozo Nagai, Takashi Daimon, Kaori Oki, Haruka Okamoto, Takeshi Yamashita, The J-Land II Study Investigators ········· 1456 27. U-Shaped Relationship Between Left Atrium Size on Echocardiography and 1-Year Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation ― Prognostic Value Study ― Qiqi Wang, Chengui Zhuo, Yunpeng Shang, Jianqiang Zhao, Nan Chen, Ning Lv, Yuan Huang, Liangrong Zheng, Jiangtao Lai, Jie Han, Zheyue Shu ········· 1463 28. Impact of Digitalis Use on Mortality in Japanese Patients With Non-Valvular Atrial Fibrillation ― A Subanalysis of the J-RHYTHM Registry ― Eitaro Kodani, Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Takeshi Yamashita, Hideki Origasa on behalf of the J-RHYTHM Registry Investigators ········· 1644 29. Efficacy and Safety of Cryoballoon Ablation in Patients With Heart Failure and Reduced Left Ventricular Ejection Fraction ― A Multicenter Study ― Christian-Hendrik Heeger, Amr Abdin, Shibu Mathew, Bruno Reissmann, Kivanc Yalin, Spyridon Liosis, Thomas Fink, Riccardo Proietti, Charlotte Eitel, Julia Vogler, Christine Lemeš, Tilman Maurer, Andreas Rillig, Roza Meyer-Saraei, Tobias Graf, Peter Wohlmuth, Britta Goldmann, Feifan Ouyang, Karl-Heinz Kuck, Andreas Metzner, Roland Richard Tilz ········· 1653 30. J-Wave Elevation in the Inferior Leads Predicts Lethal Ventricular Arrhythmia Initiated by Premature Ventricular Contractions With Right Bundle Branch Block and Superior Axis Yumi Munetsugu, Mitsuharu Kawamura, Toshihiko Gokan, Ko Ogawa, Yuya Nakamura, Akinori Ochi, Koichiro Inokuchi, Hiroyuki Ito, Tatsuya Onuki, Youichi Kobayashi, Toshiro Shinke ········· 1851 31. Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease Yuan Zhong, Kai Tang, Hailing Li, Dongdong Zhao, Wenxin Kou, Shaojie Xu, Jun Zhang, Haotian Yang, Shuang Li, Rong Guo, Wenhui Peng, Yawei Xu ········· 1994 32. Novel Device-Based Algorithm Provides Optimal Hemodynamics During Exercise in Patients With Cardiac Resynchronization Therapy Akira Kasagawa, Ikutaro Nakajima, Masaki Izumo, Yui Nakayama, Marika Yamada, Makoto Takano, Hisao Matsuda, Toshiyuki Furukawa, Hidekazu Miyazaki, Tomoo Harada, Yoshihiro J Akashi ········· 2002 33. Current Status and Clinical Outcomes of Oral Anticoagulant Discontinuation After Ablation for Atrial Fibrillation in Japan ― Findings From the AF Frontier Ablation Registry ― Yasuo Okumura, Koichi Nagashima, Masaru Arai, Ryuta Watanabe, Katsuaki Yokoyama, Naoya Matsumoto, Takayuki Otsuka, Shinya Suzuki, Akio Hirata, Masato Murakami, Mitsuru Takami, Masaomi Kimura, Hidehira Fukaya, Shiro Nakahara, Takeshi Kato, Wataru Shimizu, Yu-ki Iwasaki, Hiroshi Hayashi, Tomoo Harada, Ikutaro Nakajima, Ken Okumura, Junjiroh Koyama, Michifumi Tokuda, Teiichi Yamane, Yukihiko Momiyama, Kojiro Tanimoto, Kyoko Soejima, Noriko Nonoguchi, Koichiro Ejima, Nobuhisa Hagiwara, Masahide Harada, Kazumasa Sonoda, Masaru Inoue, Koji Kumagai, Hidemori Hayashi, Kazuhiro Satomi, Yoshinao Yazaki, Yuji Watari on behalf of the AF Ablation Frontier Registry ········· 2418 34. Development of a Novel Algorithm to Detect Atrial Fibrillation Using an Automated Blood Pressure Monitor With an Irregular Heartbeat Detector Makoto Ishizawa, Takahisa Noma, Takahiro Izumi, Ryosuke Tani, Tomoko Inoue, Eriko Nasu, Atsushi Tobiume, Yusuke Hasui, Shota Yokoyama, Hideyuki Hamaya, Shohei Ishikawa, Keiji Matsunaga, Ryo Kawakami, Kumi Konishi, Yuichi Miyake, Kaori Ishikawa, Teppei Tsuji, Kazushi Murakami, Naoki Nishimoto, Hiroyuki Kitajima, Tetsuo Minamino ········· 2428 35. Guideline-Adherent Treatment for Stroke and Death in Atrial Fibrillation Patients From UK and Japanese AF Registries Kazuo Miyazawa, Hisashi Ogawa, Michał Mazurek, Eduard Shantsila, Deirdre A. Lane, Andreas Wolff, Masaharu Akao, Gregory Y.H. Lip ········· 2434

Circulation Journal Vol.83, December 2019 viii Contents of Volume 83, 2019

36. Second-Generation Visually Guided Laser Balloon Ablation System for Pulmonary Vein Isolation: Learning Curve, Safety and Efficacy ― The MERLIN Registry ― Christian-H. Heeger, Huong-Lan Phan, Roza Meyer-Saraei, Thomas Fink, Vanessa Sciacca, Spyridon Liosis, Ben Brüggemann, Niels Große, Bezhad Fahimi, Makoto Sano, Karl-Heinz Kuck, Feifan Ouyang, Julia Vogler, Charlotte Eitel, Roland Richard Tilz ········· 2443 Biomedical Engineering (1) 37. Carotid Geometry as a Predictor of In-Stent Neointimal Hyperplasia ― A Computational Fluid Dynamics Study ― Xinke Yao, Zhengze Dai, Xu Zhang, Jie Gao, Gelin Xu, Yan Cai, Zhiyong Li ········· 1472 Cardiovascular Intervention (20) 38. Different Neoatherosclerosis Patterns in Drug-Eluting- and Bare-Metal Stent Restenosis ― Optical Coherence Tomography Study ― Daisuke Nakamura, Keisuke Yasumura, Hitoshi Nakamura, Yutaka Matsuhiro, Koji Yasumoto, Akihiro Tanaka, Yasuharu Matsunaga-Lee, Masamichi Yano, Masaki Yamato, Yasuyuki Egami, Ryu Shutta, Yasushi Sakata, Jun Tanouchi, Masami Nishino ········· 313 39. Early Venous Stent Failure Predicted by Platelet Count and Neutrophil/Lymphocyte Ratio Younes Jahangiri, Masayuki Endo, Ramsey Al-Hakim, John A. Kaufman, Khashayar Farsad ········· 320 40. Dual Anti-Thrombotic Therapy With Dabigatran After Percutaneous Coronary Intervention in Atrial Fibrillation ― Japanese and East-Asian Subgroup Analysis of the RE-DUAL PCI Trial ― Junya Ako, Ken Okumura, Koichi Nakao, Ken Kozuma, Yoshihiro Morino, Kotaro Okazaki, Taku Fukaya, Takeshi Kimura on behalf of the RE-DUAL PCI Trial Investigators ········· 327 41. Serial Optical Coherence Tomography at Baseline, 7 Days, and 1, 3, 6 and 12 Months After Bioresorbable Scaffold Implantation in a Growing Porcine Model Taku Asano, Jarkko Hytönen, Ply Chichareon, Jouni Taavitsainen, Norihiro Kogame, Yuki Katagiri, Yosuke Miyazaki, Kuniaki Takahashi, Rodrigo Modolo, Hidenori Komiyama, Erhan Tenekecioglu, Yohei Sotomi, Joanna J. Wykrzykowska, Jan J. Piek, John Martin, Andreas Baumbach, Anthony Mathur, Yoshinobu Onuma, Seppo Ylä-Herttuala, Patrick W. Serruys ········· 556 42. Safety and Efficacy of Low-Dose Prasugrel as Part of Triple Therapy With Aspirin and Oral Anticoagulants in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention ― From the TWMU-AF PCI Registry ― Hisao Otsuki, Junichi Yamaguchi, Takanori Kawamoto, Masafumi Yoshikawa, Suguru Ebihara, Kazuki Tanaka, Masashi Nakao, Kentaro Jujo, Hiroyuki Arashi, Yoshimi Ota, Katsumi Saito, Atsushi Takagi, Hiroyuki Tanaka, Shinya Fujii, Atsushi Honda, Fumiaki Mori, Nobuhisa Hagiwara ········· 1000 43. Estimating Years of Life Lost Due to Cardiovascular Disease in Japan Hidenori Arai, Kalliopi Mortaki, Pratik Rane, Casey Quinn, Zhongyun Zhao, Yi Qian ········· 1006 44. Three-Dimensional Fibrous Cap Structure of Coronary Lipid Plaque ― ST-Elevation Myocardial Infarction vs. Stable Angina ― Krzysztof L Bryniarski, Zhao Wang, Francesco Fracassi, Tomoyo Sugiyama, Erika Yamamoto, Hang Lee, James Fujimoto, Ik-Kyung Jang ········· 1214 45. Prognostic Value of Phase-Contrast Cine-Magnetic Resonance Imaging-Derived Global Coronary Flow Reserve in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome Treated With Urgent Percutaneous Coronary Intervention Yoshihisa Kanaji, Taishi Yonetsu, Rikuta Hamaya, Tadashi Murai, Eisuke Usui, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Yoshinori Kanno, Hiroaki Ohya, Youhei Sumino, Hidenori Hirano, Haruhito Yuki, Tomoki Horie, Akinori Sugano, Tetsumin Lee, Kenzo Hirao, Tsunekazu Kakuta ········· 1220 46. Primary Percutaneous Coronary Intervention in Elderly Patients With Acute Myocardial Infarction ― An Analysis From a Japanese Nationwide Claim-Based Database ― Shiro Uemura, Hiroshi Okamoto, Michikazu Nakai, Kunihiro Nishimura, Yoshihiro Miyamoto, Satoshi Yasuda, Nobuhiro Tanaka, Shun Kohsaka, Kazushige Kadota, Yoshihiko Saito, Hiroyuki Tsutsui, Issei Komuro, Yuji Ikari, Hisao Ogawa, Masato Nakamura ········· 1229 47. Long-Term Clinical Outcome of Drug-Eluting vs. Bare-Metal Stent Implantation After Percutaneous Coronary Intervention in End-Stage Renal Disease Patients on Hemodialysis ― Nationwide Cohort Study in Taiwan ― Mei-Ling Chen, Jung-Lun Wu, Michael Yu-Chih Chen, Tsung-Cheng Hsieh ········· 1239 48. Effect of Statin Therapy on Fibrous Cap Thickness in Coronary Plaque on Optical Coherence Tomography ― Review and Meta-Analysis ― Yuichi Ozaki, Hector M. Garcia-Garcia, Solomon S. Beyene, Alexandre Hideo-Kajita, Kayode O. Kuku, Paul Kolm, Ron Waksman ········· 1480 49. Long-Term Comparison of Platinum Chromium Everolimus-Eluting Stent vs. Cobalt Chromium Zotarolimus- Eluting Stent ― 3-Year Outcomes From the HOST–ASSURE Randomized Clinical Trial ― Chee Hae Kim, Kyung Woo Park, Jeehoon Kang, Byoung-Eun Park, Kwang Soo Cha, Jay Young Rhew, Hui-Kyung Jeon, Eun-Seok Shin, Ju Hyeon Oh, Myung-Ho Jeong, Sanghyun Kim, Kyung-Kuk Hwang, Jung-Han Yoon, Sung Yun Lee, Tae-Ho Park, Keon Woong Moon, Hyuck-Moon Kwon, Seung-Ho Hur, Jae-Kean Ryu, Bong-Ryul Lee, Yong Whi Park, In-Ho Chae, Hyo-Soo Kim on behalf of the HOST–ASSURE Investigators ········· 1489

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50. Cost-Effectiveness of Percutaneous Coronary Intervention Compared With Medical Therapy for Ischemic Heart Disease in Japan Satoshi Kodera, Hiroyuki Morita, Arihiro Kiyosue, Jiro Ando, Issei Komuro ········· 1498 51. Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension ― A Systematic Review and Meta-Analysis ― Giacomo Zoppellaro, Mostafa Rabea Badawy, Alessandro Squizzato, Gentian Denas, Giuseppe Tarantini, Vittorio Pengo ········· 1660 52. Utility and Validity of Intracoronary Administration of Nicorandil Alone for the Measurement of Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis Kasumi Ishibuchi, Kenichi Fujii, Satoru Otsuji, Shin Takiuchi, Katsuyuki Hasegawa, Hiroto Tamaru, Rui Ishii, Shingo Yasuda, Sho Nakabayashi, Wataru Yamamoto, Hirofumi Kusumoto, Yusuke Taniguchi, Mikio Kakishita, Yuji Shimatani, Yorihiko Higashino ········· 2010 53. Efficacy and Safety of Uninterrupted Periprocedural Edoxaban in Patients Undergoing Catheter Ablation for Atrial Fibrillation ― The Prospective KYU-RABLE Study ― Naohiko Takahashi, Yasushi Mukai, Tetsuya Kimura, Keita Yamaguchi, Takuyuki Matsumoto, Hideki Origasa, Ken Okumura on behalf of the KYU-RABLE Investigators ········· 2017 54. Effect of Alirocumab on Coronary Atheroma Volume in Japanese Patients With Acute Coronary Syndrome ― The ODYSSEY J-IVUS Trial ― Junya Ako, Kiyoshi Hibi, Kenichi Tsujita, Takafumi Hiro, Yoshihiro Morino, Ken Kozuma, Toshiro Shinke, Hiromasa Otake, Kiyoko Uno, Michael J Louie, Yoshiharu Takagi, Katsumi Miyauchi ········· 2025 55. Clinical Outcome of Lesions With Discordant Results Among Different Invasive Physiologic Indices ― Resting Distal Coronary to Aortic Pressure Ratio, Resting Full-Cycle Ratio, Diastolic Pressure Ratio, Instantaneous Wave-Free Ratio, and Fractional Flow Reserve ― Joo Myung Lee, Tae-Min Rhee, Ki Hong Choi, Jonghanne Park, Doyeon Hwang, Jinseob Kim, Jinhyoung Park, Hyung Yoon Kim, Hae Won Jung, Yun-Kyeong Cho, Hyuck-Jun Yoon, Young Bin Song, Joo-Yong Hahn, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Seung-Ho Hur, Bon-Kwon Koo ········· 2210 56. Prevalence and Clinical Significance of Layered Plaque in Patients With Stable Angina Pectoris ― Evaluation With Histopathology and Optical Coherence Tomography ― Hiroshi Okamoto, Teruyoshi Kume, Ryotaro Yamada, Terumasa Koyama, Tomoko Tamada, Koichiro Imai, Yoji Neishi, Shiro Uemura ········· 2452 57. Absorb GT1 Bioresorbable Vascular Scaffold System ― 1-Year Post-Marketing Surveillance in Japan ― Nobuaki Suzuki, Ken Kozuma, Sunao Nakamura, Kazuhiko Aramaki, Shigeru Saito, Yoshisato Shibata, Mamoru Nanasato, Kenshi Fujii, Hajime Kusano, Divine Ediebah, Masato Nakamura ········· 2460 Cardiac Rehabilitation (4) 58. Impact of Physical Activity on Coronary Plaque Volume and Components in Acute Coronary Syndrome Patients After Early Phase II Cardiac Rehabilitation Miho Nishitani-Yokoyama, Katsumi Miyauchi, Kazunori Shimada, Takayuki Yokoyama, Shohei Ouchi, Tatsuro Aikawa, Mitsuhiro Kunimoto, Miki Yamada, Akio Honzawa, Shinya Okazaki, Hiroyuki Daida ········· 101 59. Efficacy of Cardiac Rehabilitation in Heart Failure Patients With Low Body Mass Index Kyohei Marume, Seiji Takashio, Michio Nakanishi, Leon Kumasaka, Shigefumi Fukui, Kazuhiro Nakao, Tetsuo Arakawa, Masanobu Yanase, Teruo Noguchi, Satoshi Yasuda, Yoichi Goto ········· 334 60. Short-Term Change in Gait Speed and Clinical Outcomes in Older Patients With Acute Heart Failure Shinya Tanaka, Kentaro Kamiya, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Takeshi Nakamura, Masashi Yamashita, Emi Maekawa, Chiharu Noda, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Takashi Masuda, Junya Ako ········· 1860 61. Ventilatory Efficacy After Transcatheter Aortic Valve Replacement Predicts Mortality and Heart Failure Events in Elderly Patients Makoto Murata, Hitoshi Adachi, Taisuke Nakade, Yusuke Miyaishi, Hakuken Kan, Shuichi Okonogi, Jun Kuribara, Eiji Yamashita, Ren Kawaguchi, Masahiko Ezure ········· 2034 Cardiovascular Surgery (12) 62. Midterm Clinical Outcomes of the St Jude Medical Epic Porcine Bioprosthesis in the Mitral Position Taro Nakazato, Hiroki Hata, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Syunsuke Saito, Keitaro Domae, Takayoshi Ueno, Toru Kuratani, Yoshiki Sawa ········· 110 63. Modified Bicaval Technique in Orthotopic Heart Transplantation ― Comparison With Conventional Bicaval Technique ― Hong Rae Kim, Sung-Ho Jung, Jae-Joong Kim, Dong Hyun Yang, Tae-Jin Yun, Jae Won Lee ········· 117 64. Impact of Complete Revascularization on Long-Term Outcomes After Coronary Artery Bypass Grafting in Patients With Left Ventricular Dysfunction Yangsin Lee, Takayuki Ohno, Yukari Uemura, Akira Osanai, Sumio Miura, Tsuyoshi Taketani, Sachito Fukuda, Minoru Ono, Shinichi Takamoto ········· 122

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65. Cardiac Function and Type of Mitral Valve Surgery Affect Postoperative Blood Flow Pattern in the Left Ventricle Shohei Yoshida, Shigeru Miyagawa, Satsuki Fukushima, Yasushi Yoshikawa, Hiroki Hata, Shunsuke Saito, Daisuke Yoshioka, Satoshi Kainuma, Keitaro Domae, Ryohei Matsuura, Satoshi Nakatani, Koichi Toda, Yoshiki Sawa ········· 130 66. Utilization of Del Nido Cardioplegia in Adult Coronary Artery Bypass Grafting ― A Retrospective Analysis ― Christian O’Donnell, Hanjay Wang, Phat Tran, Shari Miller, Paul Shuttleworth, Jack H. Boyd ········· 342 67. Extended Posterior Leaflet Augmentation for Ischemic Mitral Regurgitation ― Augmented Posterior Leaflet Snuggling up to Anterior Leaflet ― Naoko Ikeda, Hiroki Yamaguchi, Masami Takagaki, Shinichi Mitsuyama, Mio Ebato, Kaoru Tanno, Hiromasa Nakamura, Tasuku Kadowaki, Yosuke Ueno, Hiroshi Kataoka, Takaki Uchida, Tomoyuki Aoki ········· 567 68. First Major Clinical Outcomes of Totally Endoscopic Robotic Mitral Valve Repair in Japan ― A Single-Center Experience ― Tatsuya Tarui, Norihiko Ishikawa, Takafumi Horikawa, Ryuta Seguchi, Sayaka Shigematsu, Ryuta Kiuchi, Kazuto Miyata, Shigeyuki Tomita, Hiroshi Ohtake, Go Watanabe ········· 1668 69. Which Patients Are Candidates for Minimally Invasive Mitral Valve Surgery? ― Establishment of Risk Calculators Using National Clinical Database ― Hiroyuki Nishi, Hiroaki Miyata, Noboru Motomura, Toshiki Takahashi, Yoshiki Sawa, Shinichi Takamoto on behalf of the Japan Cardiovascular Surgery Database Organization ········· 1674 70. Learning Curve Analysis to Determine Operative Requirements for Young Vascular Surgeons Learning Open Abdominal Aortic Aneurysm Repair Takuro Shirasu, Takatoshi Furuya, Motoki Nagai, Yukihiro Nomura ········· 1868 71. Prognostic Value of Preoperative Pulmonary Arterial Capacitance for Patients Undergoing Aortic Valve Replacement for Severe Aortic Valve Stenosis Keigo Yamashita, Takehisa Abe, Yoshihiro Hayata, Tomoaki Hirose, Shigeki Taniguchi ········· 2222 72. Surgical Repair of Post-Infarction Ventricular Septal Defect ― Findings From a Japanese National Database ― Genichi Sakaguchi, Hiroaki Miyata, Noboru Motomura, Chikara Ueki, Eriko Fukuchi, Hiroyuki Yamamoto, Shinichi Takamoto, Akira Marui ········· 2229 73. Bilateral Internal Thoracic Artery Grafting Concomitant With Other Cardiac Operations ― Insights From a European Multicenter Retrospective Study on 1,123 Consecutive Patients ― Giuseppe Gatti, Antonio Fiore, Chiara Zilio, Sara Michelotti, Fiona Ecarnot, Pierpaolo Taffarello, Vera Perniciaro, Luigi Priolo, Gianluca Castaldi, Placido Currò, Bernardo Benussi, Aniello Pappalardo, Sidney Chocron, Thierry Folliguet, Andrea Perrotti ········· 2466 Critical Care (5) 74. Renal Function and Outcome of Out-of-Hospital Cardiac Arrest ― Multicenter Prospective Study (SOS-KANTO 2012 Study) ― Tomoyoshi Tamura, Masaru Suzuki, Kei Hayashida, Junichi Sasaki, Naohiro Yonemoto, Atsushi Sakurai, Yoshio Tahara, Ken Nagao, Arino Yaguchi, Naoto Morimura on behalf of the SOS-KANTO 2012 Study Group ········· 139 75. Association Between Body Mass Index and Mortality in Patients Requiring Cardiac Critical Care Soo Jin Na, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Jin-Oh Choi, Joo-Yong Hahn, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Chi Ryang Chung, Kyeongman Jeon, Gee Young Suh, Joong Hyun Ahn, Keumhee C Carriere, Jeong Hoon Yang ········· 743 76. Patients With Refractory Out-of-Cardiac Arrest and Sustained Ventricular Fibrillation as Candidates for Extracorporeal Cardiopulmonary Resuscitation ― Prospective Multi-Center Observational Study ― Takahiro Nakashima, Teruo Noguchi, Yoshio Tahara, Kunihiro Nishimura, Soshiro Ogata, Satoshi Yasuda, Daisuke Onozuka, Naoto Morimura, Ken Nagao, David F Gaieski, Yasufumi Asai, Hiroyuki Yokota, Satoshi Nara, Mamoru Hase, Takahiro Atsumi, Tetsuya Sakamoto for the SAVE-J Group ········· 1011 77. Prognostic Value of Neurological Status on Hospital Arrival for Short-Term Outcome in Patients With Cardiovascular Shock ― Sub-analysis of the Japanese Circulation Society Cardiovascular Shock Registry ― Yasushi Ueki, Masahiro Mohri, Tetsuya Matoba, Toshiaki Kadokami, Satoru Suwa, Tsukasa Yagi, Hiroshi Takahashi, Nobuhiro Tanaka, Yohei Hokama, Rei Fukuhara, Ken Onitsuka, Eizo Tachibana, Naohiro Yonemoto, Ken Nagao for the Japanese Circulation Society Shock Registry Scientific Committee ········· 1247 78. Association Between Prehospital Supraglottic Airway Compared With Bag-Mask Ventilation and Glasgow– Pittsburgh Cerebral Performance Category 1 in Patients With Out-of-Hospital Cardiac Arrest Keisuke Jinno, Toru Hifumi, Tomoya Okazaki, Yasuhiro Kuroda, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Naoki Sato, Hiroyuki Tsutsui on behalf of the Japanese Circulation Society Resuscitation Science Study (JCS-ReSS) Group ········· 2479 Epidemiology (11) 79. Time-Related Changes in Relationships Between the Keys Score, Dietary Lipids, and Serum Total Cholesterol in Japan ― NIPPON DATA80/90/2010 ― Yukiko Okami, Hirotsugu Ueshima, Yasuyuki Nakamura, Keiko Kondo, Aya Kadota, Nagako Okuda, Tomonori Okamura, Katsuyuki Miura for the NIPPON DATA80/90 and NIPPON DATA2010 Research Groups ········· 147

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80. Uric Acid Level and New-Onset Atrial Fibrillation in the Japanese General Population ― Longitudinal Study ― Shin Kawasoe, Takuro Kubozono, Shiro Yoshifuku, Satoko Ojima, Masaaki Miyata, Hironori Miyahara, Shigeho Maenohara, Mitsuru Ohishi ········· 156 81. Common Genetic Variants on Bone Morphogenetic Protein Receptor Type IB (BMPR1B) Gene Are Predictive for Carotid Intima-Media Thickness Yih-Jer Wu, Yi-Nan Lee, Tzu-Wei Wu, Chao-Liang Chou, Li-Yu Wang ········· 749 82. Coffee Consumption and All-Cause and Cardiovascular Mortality ― Three-Prefecture Cohort in Japan ― Junya Sado, Tetsuhisa Kitamura, Yuri Kitamura, Rong Liu, Emiko Ando, Tomotaka Sobue, Yumi Sugawara, Keitaro Matsuo, Tomio Nakayama, Ichiro Tsuji, Hidemi Ito, Takaichiro Suzuki, Kota Katanoda, Suketami Tominaga ········· 757 83. Cardiovascular Risk Assessment Chart by Dietary Factors in Japan ― NIPPON DATA80 ― Keiko Kondo, Katsuyuki Miura, Sachiko Tanaka-Mizuno, Aya Kadota, Hisatomi Arima, Nagako Okuda, Akira Fujiyoshi, Naoko Miyagawa, Katsushi Yoshita, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima for the NIPPON DATA80 Research Group ········· 1254 84. Association of Work Situation With Cardiovascular Disease Mortality Risk Among Working-Age Japanese Men ― A 20-Year Follow-up of NIPPON DATA90 ― Nagako Okuda, Aya Kadota, Nobuo Nishi, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Atsushi Satoh, Yoshikuni Kita, Takehito Hayakawa, Naoyuki Takashima, Akira Fujiyoshi, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima for the NIPPON DATA90 Research Group ········· 1506 85. Public-Access Defibrillation and Survival of Out-of-Hospital Cardiac Arrest in Public vs. Residential Locations in Japan Takeyuki Kiguchi, Kosuke Kiyohara, Tetsuhisa Kitamura, Chika Nishiyama, Daisuke Kobayashi, Satoe Okabayashi, Tomonari Shimamoto, Tasuku Matsuyama, Takashi Kawamura, Taku Iwami ········· 1682 86. Medication Adherence/Persistence and Demographics of Japanese Dyslipidemia Patients on Statin-Ezetimibe as a Separate Pill Combination Lipid-Lowering Therapy ― An Observational Pharmacy Claims Database Study ― Tatsuya Umeda, Ai Hayashi, Go Fujimoto, Yi Piao, Nobutomo Matsui, Shigeru Tokita ········· 1689 87. Novel “Predictor Patch” Method for Adding Predictors Using Estimates From Outside Datasets ― A Proof-of- Concept Study Adding Kidney Measures to Cardiovascular Mortality Prediction ― Kunihiro Matsushita, Yingying Sang, Jingsha Chen, Shoshana H. Ballew, Michael Shlipak, Josef Coresh, Carmen A. Peralta, Mark Woodward ········· 1876 88. Cataracts and Subclinical Carotid Atherosclerosis in Older Adults ― A Cross-Sectional Study of the HEIJO-KYO Cohort ― Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Tomo Nishi, Tetsuo Ueda, Norio Kurumatani, Keigo Saeki, Nahoko Ogata ········· 2044 89. Mildly Decreased Renal Function and Its Relation to Left Ventricular Geometry Change Sung Keun Park, Ju Young Jung, Jeong Gyu Kang, Pil-Wook Chung, Jae-Hong Ryoo ········· 2236 Heart Failure (35) 90. Multicenter, Prospective Study on Respiratory Stability During Recovery From Deterioration of Chronic Heart Failure Junya Takagawa, Hidetsugu Asanoi, Tomoyuki Tobushi, Naoto Kumagai, Toshiaki Kadokami, Kaoru Dohi, Shuji Joho, Osamu Wada, Takashi Koyama, Nobuhiko Haruki, Shin-ichi Ando, Shin-ichi Momomura for the PROST Investigators ········· 164 91. Specialty-Related Differences in the Acute-Phase Treatment and Prognosis in Patients With Acute Heart Failure ― Insights From REALITY-AHF ― Toru Kondo, Takahiro Okumura, Yuya Matsue, Atsushi Shiraishi, Nobuyuki Kagiyama, Tetsuo Yamaguchi, Shunsuke Kuroda, Keisuke Kida, Atsushi Mizuno, Shogo Oishi, Yasutaka Inuzuka, Eiichi Akiyama, Ryuichi Matsukawa, Kota Kato, Satoshi Suzuki, Takashi Naruke, Kenji Yoshioka, Tatsuya Miyoshi, Yuichi Baba, Masayoshi Yamamoto, Koji Murai, Kazuo Mizutani, Kazuki Yoshida, Takeshi Kitai, Toyoaki Murohara ········· 174 92. Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure Tomohiro Hayashi, Tomoya Yamashita, Hikaru Watanabe, Kenjiro Kami, Naofumi Yoshida, Tokiko Tabata, Takuo Emoto, Naoto Sasaki, Taiji Mizoguchi, Yasuhiro Irino, Ryuji Toh, Masakazu Shinohara, Yuko Okada, Wataru Ogawa, Takuji Yamada, Ken-ichi Hirata ········· 182 93. Comparison of Characteristics and 3-Year Outcomes in Patients With Acute Heart Failure With Preserved, Mid-Range, and Reduced Ejection Fraction Jun Hwan Cho, Won-Seok Choe, Hyun-Jai Cho, Hae-Young Lee, Jieun Jang, Sang Eun Lee, Jin-Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Jae-Joong Kim, Byung-Hee Oh ········· 347 94. Effect of Statins on Mortality in Heart Failure With Preserved Ejection Fraction Without Coronary Artery Disease ― Report From the JASPER Study ― Kyohei Marume, Seiji Takashio, Toshiyuki Nagai, Kenichi Tsujita, Yoshihiko Saito, Tsutomu Yoshikawa, Toshihisa Anzai ········· 357

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95. Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice Michio Sato, Keishi Miyata, Zhe Tian, Tsuyoshi Kadomatsu, Yoshihiro Ujihara, Jun Morinaga, Haruki Horiguchi, Motoyoshi Endo, Jiabin Zhao, Shunshun Zhu, Taichi Sugizaki, Kimihiro Igata, Masashi Muramatsu, Takashi Minami, Takashi Ito, Marco E Bianchi, Satoshi Mohri, Kimi Araki, Koichi Node, Yuichi Oike ········· 368 96. Rescuing Patients With Severe Biventricular Failure in the Era of Continuous-Flow Left Ventricular Assist Device Shunsuke Saito, Koichi Toda, Teruya Nakamura, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Daisuke Yoshioka, Satoshi Kainuma, Shohei Yoshida, Yoshiki Sawa ········· 379 97. Acute Modifications of Left Ventricular Torsional Mechanics Induced by Cardiac Resynchronization Therapy Affect Short-Term Reverse Remodeling Chiara Sartori, Anna Degiovanni, Federica Devecchi, Paolo Devecchi, Paolo Nicola Marino ········· 386 98. Value of Placental Growth Factor as a Predictor of Adverse Events During the Acute Phase of Acute Decompensated Heart Failure Yasuki Nakada, Rika Kawakami, Masaru Matsui, Tomoya Ueda, Tomoya Nakano, Hitoshi Nakagawa, Taku Nishida, Kenji Onoue, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Hiroyuki Okura, Yoshihiko Saito ········· 395 99. Incremental Prognostic Value of Platelet Count in Patients With Acute Heart Failure ― A Retrospective Observational Study ― Satoshi Yamaguchi, Masami Abe, Tomohiro Arakaki, Osamu Arasaki, Michio Shimabukuro ········· 576 100. Different Impact of Changes in Left Ventricular Ejection Fraction Between Heart Failure Classifications in Patients With Acute Decompensated Heart Failure Masayoshi Yamamoto, Yoshihiro Seo, Tomoko Ishizu, Isao Nishi, Yoshie Hamada-Harimura, Tomoko Machino-Ohtsuka, Kimi Sato, Seika Sai, Tomofumi Nakatsukasa, Akinori Sugano, Masako Baba, Kenichi Obara, Kazutaka Aonuma, Masaki Ieda ········· 584 101. Left Ventricular Torsion ― A New Echocardiographic Prognosticator in Patients With Non-Ischemic Dilated Cardiomyopathy ― Mohamed Rady, Stefan Ulbrich, Felix Heidrich, Stefanie Jellinghaus, Karim Ibrahim, Axel Linke, Krunoslav Michael Sveric ········· 595 102. Age- and Body Size-Adjusted Left Ventricular End-Diastolic Dimension in a Japanese Hospital-Based Population Yuta Seko, Takao Kato, Yusuke Morita, Yuhei Yamaji, Yoshizumi Haruna, Toshiaki Izumi, Shoichi Miyamoto, Eisaku Nakane, Hideyuki Hayashi, Tetsuya Haruna, Moriaki Inoko ········· 604 103. Comparison of Mortality Prediction Models on Long-Term Mortality in Hospitalized Patients With Acute Heart Failure ― The Importance of Accounting for Nutritional Status ― Hiroki Nakano, Kazunori Omote, Toshiyuki Nagai, Michikazu Nakai, Kunihiro Nishimura, Yasuyuki Honda, Satoshi Honda, Naotsugu Iwakami, Yasuo Sugano, Yasuhide Asaumi, Takeshi Aiba, Teruo Noguchi, Kengo Kusano, Hiroyuki Yokoyama, Satoshi Yasuda, Hisao Ogawa, Taishiro Chikamori, Toshihisa Anzai on behalf of the NaDEF Investigators ········· 614 104. Prognostic Comparison of the Estimations of Renal Function in Patients With Acute Heart Failure Yu-Lun Cheng, Shih-Hsien Sung, Hao-Min Cheng, Jui-Tzu Huang, Chao-Yu Guo, Pai-Feng Hsu, Wen-Chung Yu, Chen-Huan Chen ········· 767 105. Outcome of Cardiac Light-Chain Amyloidosis in the Era of Novel Therapy ― A Single-Center Cohort Study of 227 Patients ― Jun Feng, Congli Zhang, Kaini Shen, Jian Sun, Quan Fang, Lu Zhang, Xinxin Cao, Daobin Zhou, Jian Li, Zhuang Tian ········· 775 106. Increased Plasma Adenosine Concentration in the Subacute Phase May Contribute to Attenuation of Left Ventricular Dilation in the Chronic Phase in Patients With Acute Myocardial Infarction Masanori Hatasa, Toshiki Tanaka, Shingo Minatoguchi, Yoshihisa Yamada, Hiromitsu Kanamori, Masanori Kawasaki, Kazuhiko Nishigaki, Yukihiro Esaka, Bunji Uno, Shinya Minatoguchi ········· 783 107. Differential Effectiveness of Landiolol Between Atrial Fibrillation and Atrial Flutter/Atrial Tachycardia Patients With Left Ventricular Dysfunction Eiichiro Oka, Yu-ki Iwasaki, Eugene Maru, Yuhi Fujimoto, Kanako Ito-Hagiwara, Hiroshi Hayashi, Teppei Yamamoto, Kenji Yodogawa, Meiso Hayashi, Wataru Shimizu ········· 793 108. Simple Risk Score to Predict Survival in Acute Decompensated Heart Failure ― A2B Score ― Yasuki Nakada, Rika Kawakami, Shouji Matsushima, Tomomi Ide, Koshiro Kanaoka, Tomoya Ueda, Satomi Ishihara, Taku Nishida, Kenji Onoue, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Hiroyuki Okura, Miyuki Tsuchihashi-Makaya, Hiroyuki Tsutsui, Yoshihiko Saito ········· 1019 109. Hospitalization Costs for Patients With Acute Congestive Heart Failure in Japan Koshiro Kanaoka, Satoshi Okayama, Michikazu Nakai, Yoko Sumita, Kunihiro Nishimura, Rika Kawakami, Hiroyuki Okura, Yoshihiro Miyamoto, Satoshi Yasuda, Hiroyuki Tsutsui, Issei Komuro, Hisao Ogawa, Yoshihiko Saito ········· 1025 110. Prognostic Impact of Previous Hospitalization in Acute Heart Failure Patients Keitaro Akita, Takashi Kohno, Shun Kohsaka, Yasuyuki Shiraishi, Yuji Nagatomo, Ayumi Goda, Atsushi Mizuno, Yasumori Sujino, Keiichi Fukuda, Tsutomu Yoshikawa, West Tokyo Heart Failure Registry Investigators ········· 1261

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111. Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction ― The CIBIS-J Trial ― Hiroyuki Tsutsui, Shin-ichi Momomura, Tohru Masuyama, Yoshihiko Saito, Issei Komuro, Toyoaki Murohara, Shintaro Kinugawa on behalf of CIBIS-J Investigators ········· 1269 112. Correlation of Right Ventricular Wall Stress With Plasma B-Type Natriuretic Peptide Levels in Patients With Pulmonary Hypertension Nami Uchiyama, Toshinori Yuasa, Masaaki Miyata, Yoshihisa Horizoe, Hideto Chaen, Kayoko Kubota, Kunitsugu Takasaki, Naoko Mizukami, Akira Kisanuki, Mitsuru Ohishi ········· 1278 113. Implication of Preoperative Existence of Atrial Fibrillation on Hemocompatibility-Related Adverse Events During Left Ventricular Assist Device Support Teruhiko Imamura, Koichiro Kinugawa, Minoru Ono, Osamu Kinoshita, Norihide Fukushima, Akira Shiose, Yoshiro Matsui, Kenji Yamazaki, Yoshikatsu Saiki, Akihiko Usui, Hiroshi Niinami, Goro Matsumiya, Hirokuni Arai, Yoshiki Sawa ········· 1286 114. Circulating Activin A Is a Surrogate for the Incidence of Diastolic Dysfunction and Heart Failure in Patients With Preserved Ejection Fraction Yi-Lin Tsai, Ruey-Hsing Chou, Chin-Sung Kuo, Chun-Chin Chang, Cheng-Hsueh Wu, Po-Hsun Huang, Jaw-Wen Chen, Shing-Jong Lin ········· 1514 115. Real-World Effectiveness and Tolerability of Tolvaptan in Patients With Heart Failure ― Final Results of the Samsca Post-Marketing Surveillance in Heart Failure (SMILE) Study ― Koichiro Kinugawa, Naoki Sato, Takayuki Inomata, Moriyoshi Yasuda, Toshiyuki Shimakawa, Yasuhiko Fukuta ········· 1520 116. Combination of Peak Exercise Systolic Blood Pressure and Left Atrial Diameter as a Novel Non-Spirometry Prognostic Predictor Comparable to Peak Oxygen Uptake for Heart Failure With Reduced Ejection Fraction Michio Nakanishi, Hiroyuki Miura, Kazuhiro Nakao, Masashi Fujino, Tetsuo Arakawa, Shigefumi Fukui, Takuya Hasegawa, Masanobu Yanase, Teruo Noguchi, Yoichi Goto, Satoshi Yasuda ········· 1528 117. Baseline Demographics and Clinical Characteristics in the All Nippon AF in the Elderly (ANAFIE) Registry Yukihiro Koretsune, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Ken Okumura, Wataru Shimizu, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Jumpei Kaburagi, Atsushi Takita, Hiroshi Inoue ········· 1538 118. Nationwide Survey of Multidisciplinary Care and Cardiac Rehabilitation for Patients With Heart Failure in Japan ― An Analysis of the AMED-CHF Study ― Kentaro Kamiya, Takanobu Yamamoto, Miyuki Tsuchihashi-Makaya, Toshimi Ikegame, Tetsuya Takahashi, Yukihito Sato, Norihiko Kotooka, Yoshihiko Saito, Hiroyuki Tsutsui, Hiroaki Miyata, Mitsuaki Isobe ········· 1546 119. Combination of Commonly Examined Parameters Is a Useful Predictor of Positive 99mTc-Labeled Pyrophosphate Scintigraphy Findings in Elderly Patients With Suspected Transthyretin Cardiac Amyloidosis Kyohei Marume, Seiji Takashio, Masato Nishi, Kyoko Hirakawa, Masahiro Yamamoto, Shinsuke Hanatani, Seitaro Oda, Daisuke Utsunomiya, Shinya Shiraishi, Mitsuharu Ueda, Taro Yamashita, Kenji Sakamoto, Eiichiro Yamamoto, Koichi Kaikita, Yasuhiro Izumiya, Yasuyuki Yamashita, Yukio Ando, Kenichi Tsujita ········· 1698 120. Prior History and Incidence of Cancer Impacts on Cardiac Prognosis in Hospitalized Patients With Heart Failure Akiomi Yoshihisa, Yasuhiro Ichijo, Koichiro Watanabe, Yu Sato, Yuki Kanno, Mai Takiguchi, Tetsuro Yokokawa, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Takafumi Ishida, Yasuchika Takeishi ········· 1709 121. Relationship Between Exercise Oscillatory Ventilation Loop and Prognosis of Heart Failure Taisuke Nakade, Hitoshi Adachi, Makoto Murata, Shigeru Oshima ········· 1718 122. Early Blood Pressure Reduction by Intravenous Vasodilators Is Associated With Acute Kidney Injury in Patients With Hypertensive Acute Decompensated Heart Yoshihito Arao, Akinori Sawamura, Masahiro Nakatochi, Takahiro Okumura, Hiroo Kato, Hideo Oishi, Shogo Yamaguchi, Tomoaki Haga, Tasuku Kuwayama, Tsuyoshi Yokoi, Hiroaki Hiraiwa, Toru Kondo, Ryota Morimoto, Toyoaki Murohara ········· 1883 123. Efficacy and Safety of Ivabradine in Japanese Patients With Chronic Heart Failure ― J-SHIFT Study ― Hiroyuki Tsutsui, Shin-ichi Momomura, Akira Yamashina, Hiroaki Shimokawa, Yasuki Kihara, Yoshihiko Saito, Nobuhisa Hagiwara, Hiroshi Ito, Masafumi Yano, Kazuhiro Yamamoto, Junya Ako, Takayuki Inomata, Yasushi Sakata, Takashi Tanaka, Yasushi Kawasaki on behalf of the J-SHIFT Study Investigators ········· 2049 124. H2FPEF Score for the Prediction of Exercise Intolerance and Abnormal Hemodynamics in Japanese ― Evaluation by Exercise Stress Echocardiography Combined With Cardiopulmonary Exercise Testing ― Kosuke Takahari, Takayuki Hidaka, Yusuke Ueda, Kanako Izumi, Yu Harada, Hitoshi Susawa, Mirai Kinoshita, Kiho Itakura, Hiroto Utsunomiya, Yasuki Kihara ········· 2487 Hypertension and Circulatory Control (1) 125. Sufficient and Persistent Blood Pressure Reduction in the Final Long-Term Results From SYMPLICITY HTN-Japan ― Safety and Efficacy of Renal Denervation at 3 Years ― Kazuomi Kario, Eiichiro Yamamoto, Hirofumi Tomita, Takafumi Okura, Shigeru Saito, Takafumi Ueno, Daiki Yasuhara, Kazuyuki Shimada on behalf of the SYMPLICITY HTN-Japan Investigators ········· 622

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Imaging (10) 126. Atherosclerotic Component of the Yellow Segment After Drug-Eluting Stent Implantation on Coronary Angioscopy ― An Ex-Vivo Validation Study ― Masahiko Shibuya, Kenichi Fujii, Hiroyuki Hao, Takahiro Imanaka, Ten Saita, Rika Kawakami, Kojiro Miki, Hiroto Tamaru, Tetsuo Horimatsu, Akinori Sumiyoshi, Machiko Nishimura, Seiichi Hirota, Tohru Masuyama, Masaharu Ishihara ········· 193 127. Prognostic Value of Time Interval Between Mitral and Tricuspid Valve Opening in Patients With Heart Failure Masataka Sugahara, Toshiaki Mano, Akiko Goda, Kumiko Masai, Yuko Soyama, Aika Daimon, Masanori Asakura, Tohru Masuyama ········· 401 128. Prognostic Value of Left Atrial Size and Functional Indices Measured by 3-Dimensional Speckle-Tracking Analysis Miki Tsujiuchi, Takenori Yamauchi, Mio Ebato, Hideyuki Maezawa, Ayaka Nogi, Naoko Ikeda, Takuya Mizukami, Sakura Nagumo, Yoshitaka Iso, Toshio Nakadate, Akatsuki Kokaze, Hiroshi Suzuki ········· 801 129. Clinical Impact of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve on Japanese Population in the ADVANCE Registry Yasutsugu Shiono, Hitoshi Matsuo, Tomohiro Kawasaki, Tetsuya Amano, Hironori Kitabata, Takashi Kubo, Yoshihiro Morino, Shunichi Yoda, Tomohiro Sakamoto, Hiroshi Ito, Junya Shite, Hiromasa Otake, Nobuhiro Tanaka, Mitsuyasu Terashima, Kazushige Kadota, Manesh R. Patel, Koen Nieman, Campbell Rogers, Bjarne L. Nørgaard, Jeroen J. Bax, Gilbert L. Raff, Kavitha M. Chinnaiyan, Daniel S. Berman, Timothy A. Fairbairn, Lynne M. Hurwitz Koweek, Jonathon Leipsic, Takashi Akasaka ········· 1293 130. Impact of Myocardial Fibrosis on Left Ventricular Function Evaluated by Feature-Tracking Myocardial Strain Cardiac Magnetic Resonance in Competitive Male Triathletes With Normal Ejection Fraction Enver Tahir, Jitka Starekova, Kai Muellerleile, Eric Freiwald, Alexandra von Stritzky, Julia Münch, Maxim Avanesov, Julius Matthias Weinrich, Christian Stehning, Ersin Cavus, Sebastian Bohnen, Ulf K. Radunski, Stefan Blankenberg, Gerhard Adam, Perikles Simon, Axel Pressler, Monica Patten, Gunnar K. Lund ········· 1553 131. On-Site Computed Tomography-Derived Fractional Flow Reserve Using a Machine-Learning Algorithm ― Clinical Effectiveness in a Retrospective Multicenter Cohort ― Akira Kurata, Naoki Fukuyama, Kuniaki Hirai, Naoto Kawaguchi, Yuki Tanabe, Hideki Okayama, Susumu Shigemi, Kouki Watanabe, Teruyoshi Uetani, Shuntaro Ikeda, Shinji Inaba, Teruhito Kido, Toshihide Itoh, Teruhito Mochizuki ········· 1563 132. Detection of Active Inflammation Status Around Ventricular Aneurysms in Patients With Cardiac Sarcoidosis Takuma Nanno, Shigeki Kobayashi, Ryosuke Yoshitomi, Shohei Fujii, Toshiro Kajii, Michiaki Kohno, Hironori Ishiguchi, Shinichi Okuda, Munemasa Okada, Kazuyoshi Suga, Masafumi Yano ········· 2494 133. Diagnostic Performance of High-Resolution Intravascular Ultrasound for the Detection of Plaque Rupture in Patients With Acute Coronary Syndrome Hirofumi Ohashi, Hirohiko Ando, Hiroaki Takashima, Katsuhisa Waseda, Masahiro Shimoda, Masanobu Fujimoto, Hiroaki Sawada, Akihiro Suzuki, Shinichiro Sakurai, Yusuke Nakano, Tetsuya Amano ········· 2505 134. Association of Echocardiography Before Major Elective Non-Cardiac Surgery With Improved Postoperative Outcomes ― Possible Implications for Patient Care ― Kenya Kusunose, Yuta Torii, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata ········· 2512 135. Postconditioning Accelerates Myocardial Inflammatory Resolution Demonstrated by 14C-Methionine Imaging and Attenuates Ventricular Remodeling After Ischemia and Reperfusion Junichi Taki, Anri Inaki, Hiroshi Wakabayashi, Ichiro Matsunari, Kyoko Imanaka-Yoshida, Kazuma Ogawa, Michiaki Hiroe, Kazuhiro Shiba, Seigo Kinuya ········· 2520 Ischemic Heart Disease (20) 136. Acute Coronary Syndrome With Unprotected Left Main Coronary Artery Culprit ― An Observation From the AOI- LMCA Registry ― Hirooki Higami, Mamoru Toyofuku, Takeshi Morimoto, Masanobu Ohya, Yasushi Fuku, Kyohei Yamaji, Hiromi Muranishi, Yuhei Yamaji, Koji Nishida, Daisuke Furukawa, Tomohisa Tada, Euihong Ko, Kenji Ando, Hiroki Sakamoto, Takashi Tamura, Kazuya Kawai, Kazushige Kadota, Takeshi Kimura on behalf of the AOI-LMCA Stenting Registry Investigators ········· 198 137. Prognostic Impact of β-Blocker Dose After Acute Myocardial Infarction Doyeon Hwang, Joo Myung Lee, Hyun Kuk Kim, Ki Hong Choi, Tae-Min Rhee, Jonghanne Park, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Bon-Kwon Koo, Young Jo Kim, Shung-Chull Chae, Myeong Chan Cho, Chong Jin Kim, Hyeon-Cheol Gwon, Myung Ho Jeong, Hyo-Soo Kim, The KAMIR Investigators ········· 410 138. Chest Compression Depth and Rate ― Effect on Instructor Visual Assessment of Chest Compression Quality ― Katsuya Nagafuchi, Toru Hifumi, Naoki Nishimoto, Yutaka Kondo, Kei Yoshikawa, Taku Iwami, Yasuhiro Kuroda ········· 418

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139. Long-Term Predictive Value of High-Sensitivity C-Reactive Protein for Cancer Mortality in Patients Undergoing Percutaneous Coronary Intervention Hirohisa Endo, Tomotaka Dohi, Takehiro Funamizu, Jun Shitara, Hideki Wada, Shinichiro Doi, Ryo Naito, Hirokazu Konishi, Manabu Ogita, Hiroshi Iwata, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Kazunori Shimada, Katsumi Miyauchi, Hiroyuki Daida ········· 630 140. Prasugrel for Japanese Patients With Ischemic Heart Disease in Long-Term Clinical Practice (PRASFIT-Practice II) ― A 3-Month Interim Analysis of a Postmarketing Observational Study ― Masato Nakamura, Ken Kozuma, Takanari Kitazono, Tomoko Iizuka, Toru Sekine, Kazuhito Shiosakai, Isao Usui, Seiji Kogure ········· 637 141. Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention of Recurrent Cardiovascular Events in a Real-World Cohort of Post-Acute Myocardial Infarction Patients Duo Huang, Yang-Yang Cheng, Yiu-Tung Anthony Wong, See-Yue Arthur Yung, Chor-Cheung Frankie Tam, Ki-Wan Kelvin Chan, Cheung-Chi Simon Lam, Kai-Hang Yiu, Jo Jo Hai, Chu-Pak Lau, Esther W Chan, Chern-En Chiang, Ka-Lam Wong, Tommy Cheung, Bernard Man-Yung Cheung, Ying-Qing Feng, Ning Tan, Ji-Yan Chen, Wen-Sheng Yue, Hou-Xiang Hu, Ling Chen, Hung-Fat Tse, Pak-Hei Chan, Chung-Wah Siu ········· 809 142. Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan Toshihiko Oshita, Ryuji Toh, Masakazu Shinohara, Kenta Mori, Yasuhiro Irino, Manabu Nagao, Tetsuya Hara, Hiromasa Otake, Tatsuro Ishida, Ken-ichi Hirata ········· 1032 143. Novel Acute Myocardial Infarction Risk Stratification (nARS) System Reduces the Length of Hospitalization for Acute Myocardial Infarction Kei Yamamoto, Kenichi Sakakura, Naoyuki Akashi, Yusuke Watanabe, Masamitsu Noguchi, Masaru Seguchi, Yousuke Taniguchi, Yusuke Ugata, Hiroshi Wada, Shin-ichi Momomura, Hideo Fujita ········· 1039 144. Impact of Lipoprotein (a) Levels on Long-Term Outcomes in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction Jun Shitara, Takatoshi Kasai, Hirokazu Konishi, Hirohisa Endo, Hideki Wada, Shinichiro Doi, Ryo Naito, Shuta Tsuboi, Manabu Ogita, Tomotaka Dohi, Shinya Okazaki, Katsumi Miyauchi, Hiroyuki Daida ········· 1047 145. Admission Heart Rate Is a Determinant of Effectiveness of Beta-Blockers in Acute Myocardial Infarction Patients Taishi Okuno, Jiro Aoki, Kengo Tanabe, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Junya Ako, Teruo Noguchi, Satoshi Yasuda, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Toshiaki Mano, Kazuhito Hirata, Yoshisato Shibata, Mafumi Owa, Kenichi Tsujita, Hiroshi Funayama, Nobuaki Kokubu, Ken Kozuma, Shiro Uemura, Tetsuya Tobaru, Keijiro Saku, Shigeru Ohshima, Kunihiro Nishimura, Yoshihiro Miyamoto, Hisao Ogawa, Masaharu Ishihara on behalf of J-MINUET Investigators ········· 1054 146. Remnant Lipoproteins Are Residual Risk Factor for Future Cardiovascular Events in Patients With Stable Coronary Artery Disease and On-Statin Low-Density Lipoprotein Cholesterol Levels <70 mg/dL Yuki Fujihara, Takamitsu Nakamura, Takeo Horikoshi, Jun-ei Obata, Daisuke Fujioka, Yosuke Watanabe, Kazuhiro Watanabe, Kiyotaka Kugiyama ········· 1302 147. Impact of Total Antithrombotic Effect on Bleeding Complications in Patients Receiving Multiple Antithrombotic Agents Shinya Ichikawa, Kengo Tsukahara, Shinnosuke Kikuchi, Yugo Minamimoto, Yuichiro Kimura, Kozo Okada, Yasushi Matsuzawa, Masaaki Konishi, Nobuhiko Maejima, Noriaki Iwahashi, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Kouichi Tamura, Kazuo Kimura ········· 1309 148. Duration of Clopidogrel-Based Dual Antiplatelet Therapy and Clinical Outcomes in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention ― A Real-World Observation in Taiwan From 2012 to 2015 ― Yi-Heng Li, Yu-Wei Chiu, Jun-Jack Cheng, I-Chang Hsieh, Ping-Han Lo, Meng-Huan Lei, Kwo-Chang Ueng, Fu-Tien Chiang, Shih-Hsien Sung, Jen-Yuan Kuo, Ching-Pei Chen, Wen-Ter Lai, Wen-Lieng Lee, Jyh-Hong Chen, Taiwan ACS STENT Registry Investigators ········· 1317 149. Plasma Renin Activity Is an Independent Prognosticator in Patients With Myocardial Infarction Daisuke Kamon, Hiroyuki Okura, Akihiko Okamura, Yasuki Nakada, Yukihiro Hashimoto, Yu Sugawara, Tomoya Ueda, Taku Nishida, Kenji Onoue, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito ········· 1324 150. Comparison of Minimally Invasive Direct Coronary Artery Bypass and Percutaneous Coronary Intervention Using Second-Generation Drug-Eluting Stents for Coronary Artery Disease ― Propensity Score-Matched Analysis ― Wonsuk Choi, Hyoung Woo Chang, Si-Hyuck Kang, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong Jung Kim, Jun Sung Kim, Kay-Hyun Park, Hyo-Soo Kim, Cheong Lim, Jung-Won Suh ········· 1572 151. Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase- Dependent B-Cell Lymphoma2 Signaling Rui Guo, Lu Gan, Wayne Bond Lau, Zheyi Yan, Dina Xie, Erhe Gao, Theodore A Christopher, Bernard L. Lopez, Xinliang Ma, Yajing Wang ········· 1726

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152. Prognostic Implications of Diastolic Dysfunction Change in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Eun Kyoung Kim, Joo-Yong Hahn, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Sung-A Chang, Sung-Ji Park, Seung-Hyuk Choi, Sang-Chol Lee, Hyeon-Cheol Gwon, Jae K. Oh, Seung Woo Park ········· 1891 153. Surgical Ineligibility and Long-Term Outcomes in Patients With Severe Coronary Artery Disease Yukiko Matsumura-Nakano, Hiroki Shiomi, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Kenji Ando, Kyohei Yamaji, Satoshi Shizuta, Ryuzo Sakata, Michiya Hanyu, Mitsuomi Shimamoto, Tatsuhiko Komiya, Takeshi Kimura on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators ········· 2061 154. Long-Term Incidence and Details of Bleeding Events After Everolimus-Eluting Stent Implantation ― 7–8-Year Outcomes ― Katsuya Miura, Takenobu Shimada, Masanobu Ohya, Ryosuke Murai, Hidewo Amano, Shunsuke Kubo, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazushige Kadota ········· 2242 155. Prognostic Value of Human Peripheral Monocyte Subsets for Future Coronary Events in Patients Without Significant Coronary Artery Stenosis Manabu Kashiwagi, Toshio Imanishi, Yuichi Ozaki, Akira Taruya, Tsuyoshi Nishiguchi, Yosuke Katayama, Takashi Tanimoto, Akio Kuroi, Takashi Kubo, Atsushi Tanaka, Takashi Akasaka ········· 2250 Metabolic Disorder (2) 156. Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease ― Post Hoc Analysis of the FMD-J Study A ― Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Farina Mohamad Yusoff, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi ········· 1064 157. Plasma Globotriaosylsphingosine Level as a Primary Screening Target for Fabry Disease in Patients With Left Ventricular Hypertrophy Satoshi Yamashita, Masao Saotome, Hiroshi Satoh, Jun Kajihara, Yusaku Mochizuki, Kimito Mizuno, Mamoru Nobuhara, Keisuke Miyajima, Azumi Kumazawa, Hiromutsu Tominaga, Hiroyuki Takase, Kei Tawarahara, Nobuyuki Wakahara, Masaki Matsunaga, Yasushi Wakabayashi, Yuji Matsumoto, Hajime Terada, Makoto Sano, Hayato Ohtani, Tsuyoshi Urushida, Hideharu Hayashi, Satoshi Ishii, Hiroki Maruyama, Yuichiro Maekawa ········· 1901 Molecular Cardiology (3) 158. Familial Left Ventricular Non-Compaction Is Associated With a Rare p.V407I Variant in Bone Morphogenetic Protein 10 Keiichi Hirono, Kazuyoshi Saito, Undral Munkhsaikhan, Fuyi Xu, Ce Wang, Lu Lu, Fukiko Ichida, Jeffrey A. Towbin, Enkhsaikhan Purevjav ········· 1737 159. Presence of Hypertrophic Cardiomyopathy Related Gene Mutations and Clinical Manifestations in Vietnamese Patients With Hypertrophic Cardiomyopathy Minh Thu Tran Vu, Thuy Vy Nguyen, Nha Van Huynh, Hoang Tam Nguyen Thai, Vinh Pham Nguyen, Thuy Duong Ho Huynh ········· 1908 160. Rare and Deleterious Mutations in ABCG5/ABCG8 Genes Contribute to Mimicking and Worsening of Familial Hypercholesterolemia Phenotype Hayato Tada, Hirofumi Okada, Akihiro Nomura, Satoshi Yashiro, Atsushi Nohara, Yasushi Ishigaki, Masayuki Takamura, Masa-aki Kawashiri ········· 1917 Myocardial Disease (2) 161. In-Depth Insight Into the Mechanisms of Cardiac Dysfunction in Patients With Type 1 Diabetes Mellitus Using Layer-Specific Strain Analysis Takeshi Iso, Ken Takahashi, Kana Yazaki, Mayumi Ifuku, Masaki Nii, Toshinaru Fukae, Rieko Yazawa, Akimi Ishikawa, Hidenori Haruna, Noriyuki Takubo, Mika Kurita, Fuki Ikeda, Hirotaka Watada, Toshiaki Shimizu ········· 1330 162. Clinical Profile of Thromboembolic Events in Patients With Hypertrophic Cardiomyopathy in a Regional Japanese Cohort ― Results From Kochi RYOMA Study ― Takayoshi Hirota, Toru Kubo, Yuichi Baba, Yuri Ochi, Asa Takahashi, Naohito Yamasaki, Naohisa Hamashige, Katsuhito Yamamoto, Fumiaki Kondo, Kanji Bando, Eisuke Yamada, Takashi Furuno, Toshikazu Yabe, Yoshinori L. Doi, Hiroaki Kitaoka ········· 1747 Pediatric Cardiology and Adult Congenital Heart Disease (11) 163. Prostaglandin E2 Receptor EP4 Inhibition Contracts Rat Ductus Arteriosus Toshiki Sakuma, Toru Akaike, Susumu Minamisawa ········· 209

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164. Establishment of a Healthcare System for Patients With Adult Congenital Heart Disease in Collaboration With Children’s Hospital ― The Nagano Model ― Hirohiko Motoki, Satoshi Yasukochi, Kiyohiro Takigiku, Kohta Takei, Toru Okamura, Kazuhiro Kimura, Masatoshi Minamisawa, Ayako Okada, Tatsuya Saigusa, Soichiro Ebisawa, Tatsuichiro Seto, Morio Shoda, Kenji Okada, Koichiro Kuwahara ········· 424 165. Outcomes of Common Atrioventricular Valve Repair in Patients With Single-Ventricle Physiology ― Indication, Timing and Repair Techniques ― Fengpu He, Yiping Jiao, Kai Ma, Zhongdong Hua, Hao Zhang, Jun Yan, Keming Yang, Kunjing Pang, Sen Zhang, Lei Qi, Guanxi Wang, Zicong Feng, Shoujun Li ········· 647 166. Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Rat Ductus Arteriosus Takahiro Kemmotsu, Utako Yokoyama, Junichi Saito, Satoko Ito, Azusa Uozumi, Shigeru Nishimaki, Shiho Iwasaki, Kazuo Seki, Shuichi Ito, Yoshihiro Ishikawa ········· 654 167. Usefulness of Red Blood Cell Distribution Width in the Assessment of Hemodynamics After Tetralogy of Fallot Repair Takuro Kojima, Tomohiko Imamura, Yousuke Osada, Shouta Muraji, Marie Nakano, Takayuki Oyanagi, Shigeki Yoshiba, Toshiki Kobayashi, Naokata Sumitomo ········· 818 168. Preferences Regarding Transfer of Patients With Congenital Heart Disease Who Attend Children’s Hospital Ryota Ochiai, Hitoshi Kato, Yasushi Misaki, Masahide Kaneko, Yukitaka Ikeda, Koichiro Niwa, Isao Shiraishi ········· 824 169. Polysplenia Syndrome as a Risk Factor for Early Progression of Pulmonary Hypertension Akimichi Shibata, Hiroki Mori, Kazuki Kodo, Toshio Nakanishi, Hiroyuki Yamagishi ········· 831 170. Usefulness of Liver Stiffness on Ultrasound Shear-Wave Elastography for the Evaluation of Central Venous Pressure in Children With Heart Diseases Eiko Terashi, Yoshihiko Kodama, Ayako Kuraoka, Yuichi Ishikawa, Makoto Nakamura, Koichi Sagawa, Shiro Ishikawa ········· 1338 171. Young Vasospastic Angina Patients Less Than 20 Years Old Shozo Sueda ········· 1925 172. Peripartum Management of Pregnant Women With Congenital Heart Disease Keiko Yamasaki, Hiroyuki Sawatari, Nao Konagai, Chizuko A. Kamiya, Jun Yoshimatsu, Jun Muneuchi, Mamie Watanabe, Terunobu Fukuda, Atsushi Mizuno, Ichiro Sakamoto, Kenichiro Yamamura, Tomoko Ohkusa, Hiroyuki Tsutsui, Koichiro Niwa, Akiko Chishaki ········· 2257 173. Left Ventricular Diastolic Function During the Normal Peripartum Period Yuki Kimura, Takao Kato, Hiromi Miyata, Issei Sasaki, Eri Minamino-Muta, Yoshinori Nagasawa, Shigeharu Numao, Tadayoshi Nagano, Toshihiro Higuchi, Moriaki Inoko ········· 2265 Peripheral Vascular Disease (6) 174. First-in-Man Clinical Pilot Study Showing the Safety and Efficacy of Intramuscular Injection of Basic Fibroblast Growth Factor With Atelocollagen Solution for Critical Limb Ischemia Kazunori Ono, Kenji Yanishi, Makoto Ariyoshi, Satoshi Kaimoto, Motoki Uchihashi, Keisuke Shoji, Satoaki Matoba ········· 217 175. Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-Derived Mononuclear Cells Implantation in Critical Limb Ischemia With Scleroderma ― Subanalysis of the Long-Term Clinical Outcomes Survey ― Keisuke Shoji, Kenji Yanishi, Ryusuke Yoshimi, Naoki Hamada, Kazuhisa Kondo, Kazuteru Fujimoto, Hideaki Nakajima, Koichiro Kuwahara, Yukihito Higashi, Yoshihiro Fukumoto, Toyoaki Murohara, Satoaki Matoba, TACT Follow up Study Investigators ········· 662 176. Risk Factors and Prevalence of Deep Vein Thrombosis After the 2016 Kumamoto Earthquakes Koji Sato, Kenji Sakamoto, Yoichiro Hashimoto, Kazuhiko Hanzawa, Daisuke Sueta, Sunao Kojima, Masaya Fukuda, Hiroki Usuku, Fumie Kihara, Hiroshi Hosokawa, Yohei Nagai, Makoto Nakajima, Yoshiharu Saito, Kayoko Sakai, Sumio Masunaga, Shinji Tanaka, Kazuteru Fujimoto, Kenji Morihisa, Katsuo Noda, Kazuhiro Nishigami, Kohei Nagata, Koichiro Fujisue, Noriaki Tabata, Yukio Ando, Kenichi Tsujita, Hisao Ogawa, Seiji Hokimoto on behalf of the KEEP Project ········· 1342 177. Impact of the Geriatric Nutritional Risk Index on the Long-Term Outcomes of Patients Undergoing Open Bypass for Intermittent Claudication Shinsuke Mii, Atsushi Guntani, Eisuke Kawakubo, Hirofumi Shimazoe, Masaru Ishida ········· 1349 178. Sex Differences in Clinical Characteristics and Outcomes of Patients With Venous Thromboembolism ― From the COMMAND VTE Registry ― Yusuke Yoshikawa, Yugo Yamashita, Takeshi Morimoto, Hidewo Amano, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Mamoru Toyofuku, Toshiaki Izumi, Tomohisa Tada, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Syunsuke Saga, Tomoki Sasa, Jiro Sakamoto, Minako Kinoshita, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Hiroki Shiomi, Takao Kato, Takeru Makiyama, Koh Ono, Takeshi Kimura on behalf of the COMMAND VTE Registry Investigators ········· 1581 179. Evaluation of Risk Factors for Major Amputation in Patients With Diabetes and Peripheral Artery Disease Receiving Antiplatelet Therapy ― Post Hoc Analysis of a Prospective Observational Multicenter Cohort Study (SEASON) ― Yukihito Higashi, Tetsuro Miyata, Hiroshi Shigematsu, Hideki Origasa, Masatoshi Fujita, Hiroshi Matsuo, Hiroaki Naritomi, Masahide Nakajima, Satoshi Yuki, Hideto Awano ········· 1929

Circulation Journal Vol.83, December 2019 xviii Contents of Volume 83, 2019

Preventive Medicine (4) 180. Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men ― The Japan Public Health Center-Based Prospective Study Cohort II ― Rie Hayashi, Hiroyasu Iso, Kazumasa Yamagishi, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Ehab S. Eshak, Norie Sawada, Shoichiro Tsugane for the Japan Public Health Center-Based (JPHC) Prospective Study Group ········· 1072 181. Relative Effect of Current Intensive Lipid-Lowering Drugs on Cardiovascular Outcomes in Secondary Prevention ― A Meta-Analysis of 12 Randomized Trials ― Shifei Wang, Jiancheng Xiu, Wangjun Liao, Yulin Liao, Jianping Bin ········· 1356 182. Long-Term Comparison of Ethyl Icosapentate vs. Omega-3-Acid Ethyl in Patients With Cardiovascular Disease and Hypertriglyceridemia (DEFAT Trial) Akira Sezai, Satoshi Unosawa, Makoto Taoka, Shunji Osaka, Kazuaki Obata, Sakie Kanno, Hisakuni Sekino, Masashi Tanaka ········· 1368 183. Effect of Treatment by Female Cardiologists on Short-Term Readmission Rates of Patients Hospitalized With Cardiovascular Diseases Atsuko Nakayama, Hiroyuki Morita, Takayuki Fujiwara, Issei Komuro ········· 1937 Pulmonary Circulation (4) 184. Incidence Rates of Postoperative Pulmonary Embolisms in Symptomatic and Asymptomatic Patients, Detected by Diagnostic Images ― A Single-Center Retrospective Study ― Yoshikazu Matsuoka, Hiroshi Morimatsu ········· 432 185. Clinical Characteristics and Outcomes of Venous Thromboembolisms According to an Out-of-Hospital vs. In- Hospital Onset ― From the COMMAND VTE Registry ― Yuji Nishimoto, Yugo Yamashita, Takeshi Morimoto, Syunsuke Saga, Hidewo Amano, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Mamoru Toyofuku, Toshiaki Izumi, Tomohisa Tada, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Tomoki Sasa, Jiro Sakamoto, Minako Kinoshita, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Hiroki Shiomi, Takao Kato, Takeru Makiyama, Koh Ono, Yukihito Sato, Takeshi Kimura on behalf of the COMMAND VTE Registry Investigators ········· 1377 186. Cancer-Associated Venous Thromboembolism in the Real World ― From the COMMAND VTE Registry ― Jiro Sakamoto, Yugo Yamashita, Takeshi Morimoto, Hidewo Amano, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Mamoru Toyofuku, Toshiaki Izumi, Tomohisa Tada, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Syunsuke Saga, Yuji Nishimoto, Tomoki Sasa, Minako Kinoshita, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Yusuke Yoshikawa, Hiroki Shiomi, Takao Kato, Takeru Makiyama, Koh Ono, Toshihiro Tamura, Yoshihisa Nakagawa, Takeshi Kimura on behalf of the COMMAND VTE Registry Investigators ········· 2271 187. Etiology of Exercise-Induced Pulmonary Hypertension Can Be Differentiated by Echocardiography ― Insight From Patients With Chronic Pulmonary Thromboembolism With Normal Resting Hemodynamics by Balloon Pulmonary Angioplasty ― Ayumi Goda, Kaori Takeuchi, Hanako Kikuchi, Mayumi Finger, Takumi Inami, Konomi Sakata, Kyoko Soejima, Toru Satoh ········· 2527 Regenerative Medicine (3) 188. Long-Term Results of Intracardiac Mesenchymal Stem Cell Transplantation in Patients With Cardiomyopathy Takeshi Yagyu, Satoshi Yasuda, Noritoshi Nagaya, Kaori Doi, Takeshi Nakatani, Kazuhiro Satomi, Wataru Shimizu, Kengo Kusano, Toshihisa Anzai, Teruo Noguchi, Hajime Ohgushi, Soichiro Kitamura, Kenji Kangawa, Hisao Ogawa ········· 1590 189. β-Adrenergic Blocker, Carvedilol, Abolishes Ameliorating Actions of Adipose-Derived Stem Cell Sheets on Cardiac Dysfunction and Remodeling After Myocardial Infarction Maya Adachi, Mai Watanabe, Yasutaka Kurata, Yumiko Inoue, Tomomi Notsu, Kenshiro Yamamoto, Hiromu Horie, Shogo Tanno, Maki Morita, Junichiro Miake, Toshihiro Hamada, Masanari Kuwabara, Naoe Nakasone, Haruaki Ninomiya, Motokazu Tsuneto, Yasuaki Shirayoshi, Akio Yoshida, Motonobu Nishimura, Kazuhiro Yamamoto, Ichiro Hisatome ········· 2282 190. Cathepsin S-Mediated Negative Regulation of Wnt5a/SC35 Activation Contributes to Ischemia-Induced Neovascularization in Aged Mice Wenhu Xu, Chenglin Yu, Limei Piao, Aiko Inoue, Hailong Wang, Xiangkun Meng, Xiang Li, Lan Cui, Hiroyuki Umegaki, Guo-Ping Shi, Toyoaki Murohara, Masafumi Kuzuya, Xian Wu Cheng ········· 2537 Stroke (5) 191. Safety of Anticoagulant Therapy Including Direct Oral Anticoagulants in Patients With Acute Spontaneous Intracerebral Hemorrhage Yuki Sakamoto, Chikako Nito, Yasuhiro Nishiyama, Satoshi Suda, Noriko Matsumoto, Junya Aoki, Takashi Shimoyama, Takuya Kanamaru, Kentaro Suzuki, Takuya Nishimura, Masahiro Mishina, Kazumi Kimura ········· 441

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192. Association of CYP2C19 Polymorphisms With Clopidogrel Reactivity and Clinical Outcomes in Chronic Ischemic Stroke Tomotaka Tanaka, Hiroshi Yamagami, Masafumi Ihara, Toshiyuki Miyata, Shigeki Miyata, Toshimitsu Hamasaki, Shu Amano, Kazuki Fukuma, Haruko Yamamoto, Jyoji Nakagawara, Eisuke Furui, Shinichiro Uchiyama, Boohan Hyun, Yasumasa Yamamoto, Yasuhiro Manabe, Yasuhiro Ito, Ryuzo Fukunaga, Takeo Abumiya, Masahiro Yasaka, Kazuo Kitagawa, Kazunori Toyoda, Kazuyuki Nagatsuka ········· 1385 193. Development of Quality Indicators of Stroke Centers and Feasibility of Their Measurement Using a Nationwide Insurance Claims Database in Japan ― J-ASPECT Study ― Ataru Nishimura, Kunihiro Nishimura, Daisuke Onozuka, Ryu Matsuo, Akiko Kada, Satoru Kamitani, Takahiro Higashi, Kuniaki Ogasawara, Megumi Shimodozono, Masafumi Harada, Yoichiro Hashimoto, Teruyuki Hirano, Haruhiko Hoshino, Ryo Itabashi, Yoshiaki Itoh, Toru Iwama, Tatsuo Kohriyama, Yuji Matsumaru, Toshiaki Osato, Makoto Sasaki, Yoshiaki Shiokawa, Hiroaki Shimizu, Hidehiro Takekawa, Toru Nishi, Masaaki Uno, Yoshiki Yagita, Keisuke Ido, Ai Kurogi, Ryota Kurogi, Koichi Arimura, Nice Ren, Akihito Hagihara, Shunya Takizawa, Hajime Arai, Takanari Kitazono, Susumu Miyamoto, Kazuo Minematsu, Koji Iihara ········· 2292 194. Serum Matrix Metalloproteinase-9 Is Associated With Depression After Acute Ischemic Stroke Bizhong Che, Chongke Zhong, Jinzhuo Ge, Ruyi Li, Zhengbao Zhu, Xiaoqing Bu, Tan Xu, Zhong Ju, Jiale Liu, Jintao Zhang, Jing Chen, Yonghong Zhang, Jiang He ········· 2303 195. Prevalence and Associated Stroke Risk of Human Immunodeficiency Virus-Infected Patients With Atrial Fibrillation ― A Nationwide Cohort Study ― Hyunjean Jung, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung ········· 2547 Valvular Heart Disease (10) 196. Benefit and Risk of Minimally Invasive Mitral Valve Repair for Type II Dysfunction ― Propensity Score-Matched Comparison ― Naonori Kawamoto, Satsuki Fukushima, Yusuke Shimahara, Takuma Yamasaki, Yorihiko Matsumoto, Kizuku Yamashita, Junjiro Kobayashi, Tomoyuki Fujita ········· 224 197. Greater Nocturnal Blood Pressure Is Associated With Natriuretic Peptide Level in Aortic Stenosis With Preserved Ejection Fraction Soichiro Tamura, Shinichi Iwata, Asahiro Ito, Sera Ishikawa, Kazuki Mizutani, Yasuhiro Izumiya, Tokuhiro Yamada, Takashi Murakami, Toshihiko Shibata, Minoru Yoshiyama ········· 447 198. Infective Endocarditis in Cancer Patients ― Causative Organisms, Predisposing Procedures, and Prognosis Differ From Infective Endocarditis in Non-Cancer Patients ― Kyu Kim, Darae Kim, Sang-Eun Lee, In Jeong Cho, Chi Young Shim, Geu-Ru Hong, Jong-Won Ha ········· 452 199. Underfilled Balloon-Expandable Transcatheter Aortic Valve Implantation With Ad Hoc Post-Dilation ― Pulsatile Flow Simulation Using a Patient-Specific Three-Dimensional Printing Model ― Masahiro Yamawaki, Kazuto Obama, Saeko Sasuga, Azuma Takahashi, Yoshiaki Ito, Mitsuo Umezu, Kiyotaka Iwasaki ········· 461 200. Clinical Outcomes of Transcatheter Aortic Valve Implantation in Patients With Extremely Large Annulus and SAPIEN 3 Dimensions Based on Post-Procedural Computed Tomography Masaki Miyasaka, Sung-Han Yoon, Rahul P. Sharma, Yoshio Maeno, Sandhu Jaideep, Masataka Taguri, Shigeaki Kato, Hiroyuki Kawamori, Takahiro Nomura, Tomoki Ochiai, Shadi Nemanpour, Tarun Chakravarty, Mamoo Nakamura, Cheng Wen, Raj Makkar ········· 672 201. Midterm Outcomes of Transcatheter Aortic Valve Replacement in Dialysis Patients With Aortic Valve Stenosis Koichi Maeda, Toru Kuratani, Isamu Mizote, Kazuo Shimamura, Yasuhiro Ichibori, Toshinari Onishi, Satoshi Nakatani, Takayoshi Ueno, Koichi Toda, Yasushi Sakata, Yoshiki Sawa ········· 1600 202. Usefulness of the Transcatheter Aortic Valve Replacement Risk Score to Determine Mid-Term Outcomes Mike Saji, Tetsuya Tobaru, Ryosuke Higuchi, Keitaro Mahara, Itaru Takamisawa, Nobuo Iguchi, Shinichiro Doi, Shinya Okazaki, Harutoshi Tamura, Shuichiro Takanashi, Morimasa Takayama, Mitsuaki Isobe ········· 1755 203. Reasons for Choosing Conservative Management in Symptomatic Patients With Severe Aortic Stenosis ― Observations From the CURRENT AS Registry ― Mitsuru Ishii, Tomohiko Taniguchi, Takeshi Morimoto, Hisashi Ogawa, Nobutoyo Masunaga, Mitsuru Abe, Yusuke Yoshikawa, Hiroki Shiomi, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Chisato Izumi, Makoto Miyake, Hirokazu Mitsuoka, Masashi Kato, Yutaka Hirano, Shintaro Matsuda, Kazuya Nagao, Tsukasa Inada, Hiroshi Mabuchi, Yasuyo Takeuchi, Keiichiro Yamane, Mamoru Toyofuku, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Tomoyuki Ikeda, Akihiro Komasa, Katsuhisa Ishii, Kozo Hotta, Nobuya Higashitani, Yoshihiro Kato, Yasutaka Inuzuka, Toshikazu Jinnai, Yuko Morikami, Masaharu Akao, Kenji Minatoya, Takeshi Kimura on behalf of the CURRENT AS Registry Investigators ········· 1944 204. Global Investigation of Immune Repertoire Suggests Kawasaki Disease Has Infectious Cause Ho-Chang Kuo, Cheng-Tsung Pan, Ying-Hsien Huang, Fu-Chen Huang, Yeong-Shin Lin, Sung-Chou Li, Lien-Hung Huang ········· 2070

Circulation Journal Vol.83, December 2019 xx Contents of Volume 83, 2019

205. Association of Relatively Short Posterior Mitral Leaflet With Mitral Regurgitation in Patients With Atrial Fibrillation Hiroki Takada, Hidekazu Tanaka, Shun Yokota, Jun Mukai, Makiko Suto, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Kensuke Matsumoto, Koji Fukuzawa, Ken-ichi Hirata ········· 2312 Vascular Biology and Vascular Medicine (5) 206. Preserved Vasoconstriction and Relaxation of Saphenous Vein Grafts Obtained by a No-Touch Technique for Coronary Artery Bypass Grafting Toshiyuki Yamada, Takeshi Adachi, Yasuo Ido, Nobuyuki Masaki, Takumi Toya, Tomoya Uchimuro, Kosaku Nishigawa, Hisao Suda, Motohiko Osako, Masataka Yamazaki, Shuichiro Takanashi, Hideyuki Shimizu ········· 232 207. Clinical Importance of Drug-Drug Interaction Between Warfarin and Prednisolone and Its Potential Mechanism in Relation to the Niemann-Pick C1-Like 1-Mediated Pathway Sayo M Ito, Yoshihide Yamanashi, Tappei Takada, Hiroshi Suzuki ········· 471 208. Safety and Effectiveness of Edoxaban in Japanese Patients With Venous Thromboembolism ― An Interim Analysis of Data From a Japanese Postmarketing Observational Study (ETNA-VTE-Japan) ― Mashio Nakamura, Norikazu Yamada, Tomohiko Asamura, Kazuhito Shiosakai, Kazuhiro Uchino ········· 1394 209. Atorvastatin Blocks Advanced Glycation End Products Induced Reduction in Macrophage Cholesterol Efflux Mediated With ATP-Binding Cassette Transporters G 1 Lei Xu, Yi-ru Wang, Pei-cheng Li, Bo Feng ········· 1954 210. Inhibition of Soluble Epoxide Hydrolase in Macrophages Ameliorates the Formation of Foam Cells ― Role of Heme Oxygenase-1 ― Hongchun Peng, Jianjun Tang, Shuiping Zhao, Li Shen, Danyan Xu ········· 2555

Rapid Communications

1. Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease Yuya Kitani, Naoki Nakagawa, Naka Sakamoto, Toshiharu Takeuchi, Fumihiko Takahashi, Ken Momosaki, Kimitoshi Nakamura, Fumio Endo, Hiroki Maruyama, Naoyuki Hasebe ········· 481 2. Rapid Deployment Aortic Valve Replacement via Right Lateral Mini-Thoracotomy ― First Clinical Experience in Japan ― Hiroki Hata, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Satoshi Kainuma, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Shohei Yoshida, Yoshiki Sawa ········· 485 3. Survival of Heart Transplant Candidates in Japan Shinichi Nunoda, Taro Sasaoka, Yasushi Sakata, Minoru Ono, Yoshiki Sawa, Mitsuaki Isobe, The Heart Transplantation Committee of the Japanese Circulation Society ········· 681 4. Heart Transplantation Ameliorates Ambulation Capacity in Patients With Muscular Dystrophy ― An Analysis of 9 Cases ― Osamu Seguchi, Kensuke Kuroda, Tomoyuki Fujita, Yuto Kumai, Seiko Nakajima, Takuya Watanabe, Masanobu Yanase, Yorihiko Matsumoto, Satsuki Fukushima, Koichi Kimura, Norihide Fukushima ········· 684 5. Temporal Trends in Acute Myocardial Infarction Incidence and Mortality Between 2006 and 2016 in Tokyo ― Report From the Tokyo CCU Network ― Takeshi Yamamoto, Nobuko Yoshida, Morimasa Takayama, Tokyo CCU Network ········· 1405 6. Intravascular Ultrasound-Guidance Is Associated With Lower Cardiovascular Mortality and Myocardial Infarction for Drug-Eluting Stent Implantation ― Insights From an Updated Meta-Analysis of Randomized Trials ― Islam Y. Elgendy, Ahmed N. Mahmoud, Akram Y. Elgendy, Gary S. Mintz ········· 1410 7. Survey of Palliative Sedation at End of Life in Terminally Ill Heart Failure Patients ― A Single-Center Experience of 5-Year Follow-up ― Yasuhiro Hamatani, Eri Nakai, Emi Nakamura, Michi Miyata, Yukie Kawano, Yasuko Takada, Yuta Anchi, Sayaka Funabashi, Atsushi Hirayama, Kensuke Kuroda, Masashi Amano, Yasuo Sugano, Toshihisa Anzai, Chisato Izumi ········· 1607 8. Impacts of Left Bundle/Peri-Left Bundle Pacing on Left Ventricular Contraction Eriko Hasumi, Katsuhito Fujiu, Koki Nakanishi, Issei Komuro ········· 1965 9. Three-Dimensional Understanding of Complexity of the Aortic Root Anatomy as the Basis of Routine Two- Dimensional Echocardiographic Measurements Shumpei Mori, Yu Izawa, Shinsuke Shimoyama, Justin T. Tretter ········· 2320

Images in Cardiovascular Medicine

1. Calcified Masses in the Inferior Vena Cava Yoshiharu Soga, Hiromasa Kira, Makoto Wakamiya, Naomi Manabe, Takamitsu Su, Kazuhiko Doi, Akira Nakano, Yoshihiro Himura ········· 239

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2. Efficacy of Pericardial Drainage in Annular Rupture and Periaortic Hematoma After Transcatheter Aortic Valve Replacement Tetsu Tanaka, Kazuyuki Yahagi, Taishi Okuno, Kei Sato, Akira Osanai, Motoi Yokozuka, Sumio Miura, Kengo Tanabe ········· 241 3. Usefulness of Buddy Wire Technique During Transcatheter Transseptal Mitral Valve Implantation in Degenerated Mitral Bioprosthesis Daisuke Hachinohe, Azeem Latib, Satoru Mitomo, Matteo Montorfano, Antonio Colombo ········· 243 4. Coronary Lesions in Takayasu Arteritis With Chronic Myelogenous Leukemia ― Intravascular Assessment With Optical Coherence Tomography and Fractional Flow Reserve ― Teodora Donisan, Dinu Valentin Balanescu, Elie Mouhayar, Jean Tayar, Cezar Iliescu ········· 245 5. Extensive Necrosis Due to Vasopressors in Septic Shock Luisa Maria Charco-Roca, Ana Maria Rodilla-Fiz, Juan Jose Pazos-Crespo ········· 247 6. Unusual Mass in the Left Ventricle Janusz Kochanowski, Monika Budnik, Monika Odyniec-Nowacka, Grzegorz Opolski ········· 488 7. Multiple Bee Sting-Induced Life-Threatening Takotsubo Cardiomyopathy Jun Aono, Makoto Saito, Shinji Inaba, Akira Kurata, Teruyoshi Uetani, Suguru Annen, Haruhiko Higashi, Jitsuo Higaki, Shuntaro Ikeda ········· 489 8. Progression of a Calcified Nodule Causing Acute Myocardial Infarction in a Patient on Hemodialysis ― Serial Optical Coherence Tomography ― Junichi Sugiura, Makoto Watanabe, Nozomi Toyokawa, Daisuke Kamon, Takuya Isojima, Tomoya Ueda, Tsunenari Soeda, Hiroyuki Okura, Yoshihiko Saito ········· 490 9. “To and Fro” Paradoxical Thrombus in the Left Heart Takatomo Watanabe, Hideshi Okada, Kazumasa Shibuya, Megumi Kobayashi, Kodai Suzuki, Genki Naruse, Tomonori Kawaguchi, Hiroaki Ushikoshi, Shozo Yoshida, Hiroyasu Ito, Masanori Kawasaki, Shinji Ogura ········· 491 10. Successful Percutaneous Coronary Intervention to Single Coronary Artery From the Right Sinus of Valsalva Yumi Ishii, Hidefumi Akioka, Kunio Yufu, Kyoko Kawano, Miho Miyoshi, Takaaki Imamura, Reika Ayabe, Hidekazu Kondo, Shotaro Saito, Akira Fukui, Norihiro Okada, Tetsuji Shinohara, Yasushi Teshima, Mikiko Nakagawa, Naohiko Takahashi ········· 492 11. Subclavian Steal Syndrome as a Common Denominator of Both Acute Coronary Syndrome and Ipsilateral Transient Ischemic Attack Andreas Mitsis, Xun Yuan, Christoph A. Nienaber ········· 687 12. Multivessel Disease With Recanalized Thrombus ― Etiologic Insights From Optical Coherence Tomography ― Yongcheol Kim, Myung Ho Jeong, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn ········· 688 13. Quantification of Abdominal Aortic Aneurysm Calcification Using the Agatston Method Can Predict Accelerated Expansion Rate Atsuko Nakayama, Hiroyuki Morita, Katsuyuki Hoshina, Issei Komuro ········· 689 14. Transthyretin Stabilizer Is Associated With Expanding Apical Sparing Area and Improving Global Cardiac Function in a Patient With Wild-Type Cardiac Amyloidosis Tomoko S. Kato, Naoko Ikeda, Mathew S. Maurer, Yukio Ando, Kaoru Tanno ········· 690 15. Supra-Annular Transcatheter Aortic Valve Position May Correct Annular Under-Expansion Due to Valvular Asymmetry Ozan Mehmet Demir, Satoru Mitomo, Francesco Giannini, Antonio Mangieri, Marco B. Ancona, Matteo Montorfano, Azeem Latib, Antonio Colombo ········· 691 16. Intramural Coronary Amyloidosis Mimicking Effort Angina Pectoris Preceding Fatal Heart Failure Miwa Ishida, Hisahito Shinagawa, Yoko Yamada, Tomohiro Mizutani, Atsuko Hara, Junya Ako, Takayuki Inomata ········· 837 17. Total Anomalous Pulmonary Venous Connection ― Least Common Type Delineated on Computed Tomography ― Fumiya Yoneyama, Toru Okamura ········· 838 18. Myocardial Rupture Due to Metastasis of Urothelial Carcinoma Kotaro Sugimoto, Mizuko Tanaka, Hideki Chiba ········· 839 19. Angiographic Appearance of Patent Saphenous Vein Graft 32 Years After Coronary Artery Bypass Grafting Hiroshi Furukawa, Naoki Yamane, Takeshi Honda, Takahiko Yamasawa, Yuji Kanaoka, Kazuo Tanemoto ········· 840 20. Peripheral Signs of Infective Endocarditis Hiroaki Kubota, Tatsuya Kawasaki, Hirofumi Kawamata, Michiyo Yamano, Tadaaki Kamitani, Tomoki Miyoshi ········· 841 21. Platypnea-Orthodeoxia Syndrome Due to Atrial Septal Defect and Combined Thoracic Deformities in a Young Woman Ryotaro Asano, Shigefumi Fukui, Tatsuya Nishii, Nao Konagai, Takuya Hasegawa, Masataka Kitano, Takeshi Ogo, Satoshi Yasuda ········· 1080 22. Awareness of Scleroderma Peripheral Artery Disease Presenting With Critical Limb Ischemia in Elderly Patients Sayaka Funabashi, Osami Kawarada, Toru Hirano, Shinobu Ayabe, Takeshi Yagyu, Teruo Noguchi, Satoshi Yasuda ········· 1081

Circulation Journal Vol.83, December 2019 xxii Contents of Volume 83, 2019

23. Optical Frequency Domain Imaging and Intravascular Ultrasound for Adult-Onset Kawasaki Disease in the Sub- Acute Phase Toshiki Kuno, Akimichi Shibata, Masaki Kodaira, Yohei Numasawa ········· 1082 24. Intramyocardial Hematoma After Radiofrequency Catheter Ablation Joy C.Y. Chen, Michel T. Corban, Philip L. Wackel, Charlotte S. Van Dorn, Joseph A. Dearani, Lawrence J. Sinak ········· 1083 25. Plaque Stabilization by Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor in a Patient With Familial Hypercholesterolemia Undergoing Percutaneous Coronary Intervention Hideki Kitahara, Naoto Mori, Yuichi Saito, Takashi Nakayama, Yoshihide Fujimoto, Yoshio Kobayashi ········· 1084 26. Austin Flint Murmur Nozomi Yoshioka, Tatsuya Kawasaki, Michiyo Yamano, Kuniyasu Harimoto, Tadaaki Kamitani ········· 1414 27. Infective Endocarditis Involving Mitral Annular Calcification Leading to Abscess Formation Rupture Into Pericardium Takaya Ozawa, Shoji Kawakami, Manabu Matsumoto, Hatsue Ishibashi-Ueda, Toshiyuki Nagai, Teruo Noguchi, Satoshi Yasuda ········· 1415 28. Simultaneous Pulmonary Arterial and Venous Round Structures in Pulmonary Aspergillosis Shusuke Yagi, Hiromu Yamazaki, Susumu Nishio, Kenya Kusunose, Hirotsugu Yamada, Masataka Sata ········· 1416 29. Successful Bipolar Radiofrequency Catheter Ablation of Premature Ventricular Contractions Originating From the Left Ventricular Posterior Papillary Muscle Takumi Yamada ········· 1417 30. Magmaris Bioresorbable Scaffold ― Possible Dismantling 2 Months After Implantation on Intravascular Ultrasound ― Satoru Mitomo, Ozan M. Demir, Francesco Giannini, Azeem Latib, Antonio Colombo ········· 1418 31. Pulmonary Sequestration With Abdominal Aorta Feeding Vessel in an Infant Haisong Bu, Tianli Zhao ········· 1612 32. Takotsubo Cardiomyopathy Mimicking Acute Coronary Syndrome ― Extracellular Volume Quantification Using Cardiac Computed Tomography ― Daisuke Sueta, Seitaro Oda, Eiichiro Yamamoto, Masato Nishi, Koichi Kaikita, Masafumi Kidoh, Daisuke Utsunomiya, Takeshi Nakaura, Yasuyuki Yamashita, Kenichi Tsujita ········· 1613 33. Dynamic QT Changes in Long QT Syndrome Type 8 Mizuki Harada, Hiroshi Suzuki, Seiko Ohno, Junichi Ozawa, Akihiko Saitoh, Minoru Horie ········· 1614 34. Isolated Right Ventricular Apical Hypoplasia Without Atrial Septal Defect Yasuhiro Otsuka, Koji Sato, Daisuke Sueta, Satoru Suzuki, Osamu Matsuo, Hiroki Usuku, Kanako Imamura, Seiji Takashio, Seitaro Oda, Yuichiro Arima, Kenji Sakamoto, Eiichiro Yamamoto, Shota Nakamura, Hiroaki Kawano, Koichi Kaikita, Kenichi Tsujita ········· 1615 35. Rivaroxaban for Fully Occlusive Inferior Vena Cava Filter Thrombus Akiya Sakatani, Mayu Nishio, Kiyoshi Kume, Yasuji Doi, Keiji Hirooka ········· 1616 36. Unusual Case of Recurrent Pericardial Effusion ― Erdheim-Chester Disease ― Ji-hun Jang, Jaewon Oh, Hyo Sup Shim, Seok-Min Kang ········· 1762 37. Mechanism of Good Back-up Support With a Deep-Seated Guiding Catheter During Percutaneous Coronary Intervention Kensuke Yokoi, Isamu Mizote, Tatsuya Shiraki, Seiko Ide, Tomohito Ohtani, Shungo Hikoso, Yuji Ikari, Yasushi Sakata ········· 1763 38. Autotransplantation for Cardiac Sarcoma With Fenestrated Patch and In Situ Pulmonary Vein Fixation Kota Suzuki, Koichi Toda, Shunsuke Saito, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Daisuke Yoshioka, Keitaro Domae, Ryohei Matsuura, Yoshiki Sawa ········· 1764 39. Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor Yasushi Ino, Takashi Kubo, Kunihiro Shimamura, Masahiro Takahata, Yoshiki Matsuo, Hironori Kitabata, Yasutsugu Shiono, Teruaki Wada, Kosei Terada, Yosuke Katayama, Hiroki Emori, Daisuke Higashioka, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka ········· 1765 40. Image Diagnosis ― Interrupted Aortic Arch in a Child With Differential Cyanosis ― Haisong Bu, Xueyang Gong ········· 1766 41. Earthquake-Induced Torsade de Pointes in Long-QT Syndrome Shoko Nakagawa, Takeshi Aiba, Kenzaburo Nakajima, Naoya Kataoka, Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Kenichiro Yamagata, Yuko Inoue, Koji Miyamoto, Satoshi Nagase, Takashi Noda, Yoshihiro Miyamoto, Satoshi Yasuda, Wataru Shimizu, Kengo Kusano ········· 1968 42. Epicardial Stone ― Unfamiliar Calcified Mass at the Site of Left Ventricular Old Myocardial Infarction ― Hiroaki Tabata, Hirohiko Motoki, Takahiro Sakai, Ayako Okada, Koichiro Kuwahara ········· 1969 43. High-Resolution Angioscopy of Endoluminal Stent Graft at 6 Months After Implantation Makoto Hoyano, Kazuyuki Ozaki, Kota Nishida, Ryohei Sakai, Naoki Kubota, Toshiki Takano, Takeshi Okubo, Shinpei Kimura, Takao Yanagawa, Takuya Ozawa, Takeshi Kashimura, Tohru Minamino ········· 1970

Circulation Journal Vol.83, December 2019 Contents of Volume 83, 2019 xxiii

44. Early In-Stent Restenosis Due to Delayed Protrusion of Underlying Atheromatous Plaque Munemitsu Otagaki, Koichiro Matsumura, Kenichi Fujii, Hiromi Kin, Yoshihiro Yamamoto, Ichiro Shiojima ········· 1971 45. Progressive Aortic Calcification as a Complication of Dermatomyositis Seigo Miyoshi, Takuya Matsumoto, Teruki Kidani, Eiji Sugimoto, Yukihiro Nakamura, Tetsuya Yamamoto, Takahide Kato, Shoicihiro Yamamoto, Chizuru Hamada, Naohiko Hamaguchi, Yasuhito Hamaguchi, Osamu Yamaguchi ········· 1972 46. Esophagus Sandwiched Between the Descending Aorta and Left Atrium ― Pitfalls of Esophageal Cooling During Radiofrequency Hot Balloon Ablation ― Yuta Okabe, Hiro Yamasaki, Yukio Sekiguchi, Kazutaka Aonuma, Akihiko Nogami, Masaki Ieda ········· 2079 47. Impella 5.0 Mechanical Assist Device Catheter-Induced Severe Hemolysis Due to Giant Swinging Motion ― New Concern in Impella Usage ― Yasuhisa Nakao, Jun Aono, Tatsuro Tasaka, Teruyoshi Uetani, Haruhiko Higashi, Shuntaro Ikeda, Toshihiro Yorozuya, Hironori Izutani, Osamu Yamaguchi ········· 2080 48. Ultrastructural Evidence of Glycosphingolipid Degradation After Enzyme Replacement Therapy in Patients With Fabry Disease Kenji Onoue, Genzou Takemura, Tomoya Nakano, Nagisa Miyazaki, Akiko Tsujimoto, Takatomo Watanabe, Hideshi Okada, Hiromitsu Kanamori, Junichi Sugiura, Koshiro Kanaoka, Satomi Ishihara, Manabu Horii, Yasuhiro Akai, Yasuhiro Sakaguchi, Yoshihiko Saito ········· 2081 49. Successful Transvenous Pacemaker Implantation via Re-Directed Left Superior Vena Cava Tatsuyuki Sato, Junichi Ishida, Toshiya Kojima, Issei Komuro ········· 2082 50. Calcified Nodule Observed on Coronary Angioscopy Tomoyuki Umemoto, Shun Nakagama, Tetsumin Lee, Taishi Yonetsu ········· 2083 51. Multiple Arterial Dissections in a Patient With Vascular Ehlers-Danlos Syndrome Caused by a Frameshift Mutation in COL3A1 Takeshi Yagyu, Kazufumi Ida, Teruo Noguchi, Satoshi Yasuda ········· 2324 52. Very Large Patent Ductus Arteriosus With Severe Pulmonary Arterial Hypertension Nao Konagai, Shigefumi Fukui, Masataka Kitano, Kazuto Fujimoto, Tatsuya Nishii, Takeshi Ogo, Satoshi Yasuda ········· 2325 53. Zero-Contrast Optical Coherence Tomography- and Physiology-Guided Percutaneous Coronary Intervention for Severely Calcified Lesion Kiyoshi Asakura, Yoshiyasu Minami, Takao Shimohama, Junya Ako ········· 2326 54. Ablation From the Right Coronary Cusp Eliminated Premature Ventricular Contractions Originating From the Proximal Left Anterior Fascicle Songwen Chen, Keping Yang, Xiaofeng Lu, Shaowen Liu ········· 2327 55. Mutant Thr95Ile Transthyretin-Related Cardiac Amyloidosis With Polyneuropathy Kihyun Kim, Jaewon Oh, Seung-Tae Lee, Hyo Sup Shim, Seok-Min Kang ········· 2328 56. Early Localized Ventricular Septal Aneurysm Formation in Acute Eosinophilic Myocarditis Naoki Fujimoto, Toru Sato, Keishi Moriwaki, Emiyo Sugiura, Shiro Nakamori, Kyoko Imanaka-Yoshida, Masaaki Ito, Kaoru Dohi ········· 2567 57. Silent Aspiration of Esophageal Cooling Solution During Pulmonary Vein Isolation Using Hot Balloon Akio Chikata, Takeshi Kato, Kazuo Usuda, Masayuki Takamura ········· 2568 58. Long-Term Myocardial Damage in Peripartum Cardiomyopathy Associated With Myocarditis Hiroaki Kawano, Tomayoshi Hayashi, Yuji Koide, Koji Maemura ········· 2569 59. Pulmonary Perfusion Scintigraphy ― Non-Invasive Method to Confirm Platypnea-Orthodeoxia Syndrome Treatment Effectiveness ― Hana Mizutani, Yoshito Ogihara, Naoki Fujimoto, Daisuke Izumi, Hiroyuki Ohashi, Yoshihide Mitani, Masaaki Ito, Kaoru Dohi ········· 2570 60. Radiation-Induced Myocardial Injury Detected on Computed Tomography Myocardial Perfusion Imaging Yumi Hirota, Keishi Moriwaki, Tairo Kurita, Masaaki Ito, Kaoru Dohi ········· 2571

JCS Guidelines

1. Guidelines for the Treatment of Pulmonary Hypertension (JCS 2017/JPCPHS 2017) Keiichi Fukuda, Hiroshi Date, Shozaburo Doi, Yoshihiro Fukumoto, Norihide Fukushima, Masaru Hatano, Hiroshi Ito, Masataka Kuwana, Hiromi Matsubara, Shin-ichi Momomura, Masaharu Nishimura, Hitoshi Ogino, Toru Satoh, Hiroaki Shimokawa, Keiko Yamauchi-Takihara, Koichiro Tatsumi, Hatsue Ishibashi-Ueda, Norikazu Yamada, Shunji Yoshida, Kohtaro Abe, Aiko Ogawa, Takeshi Ogo, Takatoshi Kasai, Masaharu Kataoka, Takashi Kawakami, Shigetoyo Kogaki, Mashio Nakamura, Tomotaka Nakayama, Mari Nishizaki, Koichiro Sugimura, Nobuhiro Tanabe, Ichizo Tsujino, Atsushi Yao, Takashi Akasaka, Motomi Ando, Takeshi Kimura, Takayuki Kuriyama, Norifumi Nakanishi, Toshio Nakanishi, Hiroyuki Tsutsui on behalf of the Japanese Circulation Society and the Japanese Pulmonary Circulation and Pulmonary Hypertension Society Joint Working Group ········· 842

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2. JCS 2018 Guideline on Diagnosis and Treatment of Acute Coronary Syndrome Kazuo Kimura, Takeshi Kimura, Masaharu Ishihara, Yoshihisa Nakagawa, Koichi Nakao, Katsumi Miyauchi, Tomohiro Sakamoto, Kenichi Tsujita, Nobuhisa Hagiwara, Shunichi Miyazaki, Junya Ako, Hirokuni Arai, Hideki Ishii, Hideki Origuchi, Wataru Shimizu, Hirofumi Takemura, Yoshio Tahara, Yoshihiro Morino, Kenji Iino, Tomonori Itoh, Yoshitaka Iwanaga, Keiji Uchida, Hirohisa Endo, Ken Kongoji, Kenji Sakamoto, Hiroki Shiomi, Takao Shimohama, Atsushi Suzuki, Jun Takahashi, Ichiro Takeuchi, Akihito Tanaka, Toshihiro Tamura, Takahiro Nakashima, Teruo Noguchi, Daisuke Fukamachi, Tomohiro Mizuno, Junichi Yamaguchi, Kenji Yodogawa, Masami Kosuge, Shun Kohsaka, Hideaki Yoshino, Satoshi Yasuda, Hiroaki Shimokawa, Atsushi Hirayama, Takashi Akasaka, Kazuo Haze, Hisao Ogawa, Hiroyuki Tsutsui, Tsutomu Yamazaki on behalf of the Japanese Circulation Society Joint Working Group ········· 1085 3. JCS 2017 Guideline on Prevention and Treatment of Infective Endocarditis Satoshi Nakatani, Takahiro Ohara, Kyomi Ashihara, Chisato Izumi, Shiro Iwanaga, Kiyoyuki Eishi, Yutaka Okita, Masao Daimon, Toshimi Kimura, Kazunori Toyoda, Hiroyuki Nakase, Kazuhiko Nakano, Masahiro Higashi, Kotaro Mitsutake, Tomoaki Murakami, Satoshi Yasukochi, Shuhei Okazaki, Haruo Sakamoto, Hiroshi Tanaka, Ichiro Nakagawa, Ryota Nomura, Katsuhito Fujiu, Takashi Miura, Toshio Morizane on behalf of the Japanese Circulation Society Joint Working Group ········· 1767 4. JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ― Hiroyuki Tsutsui, Mitsuaki Isobe, Hiroshi Ito, Hiroshi Ito, Ken Okumura, Minoru Ono, Masafumi Kitakaze, Koichiro Kinugawa, Yasuki Kihara, Yoichi Goto, Issei Komuro, Yoshikatsu Saiki, Yoshihiko Saito, Yasushi Sakata, Naoki Sato, Yoshiki Sawa, Akira Shiose, Wataru Shimizu, Hiroaki Shimokawa, Yoshihiko Seino, Koichi Node, Taiki Higo, Atsushi Hirayama, Miyuki Makaya, Tohru Masuyama, Toyoaki Murohara, Shin-ichi Momomura, Masafumi Yano, Kenji Yamazaki, Kazuhiro Yamamoto, Tsutomu Yoshikawa, Michihiro Yoshimura, Masatoshi Akiyama, Toshihisa Anzai, Shiro Ishihara, Takayuki Inomata, Teruhiko Imamura, Yu-ki Iwasaki, Tomohito Ohtani, Katsuya Onishi, Takatoshi Kasai, Mahoto Kato, Makoto Kawai, Yoshiharu Kinugasa, Shintaro Kinugawa, Toru Kuratani, Shigeki Kobayashi, Yasuhiko Sakata, Atsushi Tanaka, Koichi Toda, Takashi Noda, Kotaro Nochioka, Masaru Hatano, Takayuki Hidaka, Takeo Fujino, Shigeru Makita, Osamu Yamaguchi, Uichi Ikeda, Takeshi Kimura, Shun Kohsaka, Masami Kosuge, Masakazu Yamagishi, Akira Yamashina on behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group ········· 2084 5. JCS 2016 Guideline on Diagnosis and Treatment of Cardiac Sarcoidosis ― Digest Version ― Fumio Terasaki, Arata Azuma, Toshihisa Anzai, Nobukazu Ishizaka, Yoshio Ishida, Mitsuaki Isobe, Takayuki Inomata, Hatsue Ishibashi-Ueda, Yoshinobu Eishi, Masafumi Kitakaze, Kengo Kusano, Yasushi Sakata, Noriharu Shijubo, Akihito Tsuchida, Hiroyuki Tsutsui, Takatomo Nakajima, Satoshi Nakatani, Taiko Horii, Yoshikazu Yazaki, Etsuro Yamaguchi, Tetsuo Yamaguchi, Tomomi Ide, Hideo Okamura, Yasuchika Kato, Masahiko Goya, Mamoru Sakakibara, Kyoko Soejima, Toshiyuki Nagai, Hiroshi Nakamura, Takashi Noda, Takuya Hasegawa, Hideaki Morita, Tohru Ohe, Yasuki Kihara, Yoshihiko Saito, Yukihiko Sugiyama, Shin-ichiro Morimoto, Akira Yamashina on behalf of the Japanese Circulation Society Joint Working Group ········· 2329 6. Guideline on the Use of Iodinated Contrast Media in Patients With Kidney Disease 2018 Yoshitaka Isaka, Hiromitsu Hayashi, Kazutaka Aonuma, Masaru Horio, Yoshio Terada, Kent Doi, Yoshihide Fujigaki, Hideo Yasuda, Taichi Sato, Tomoyuki Fujikura, Ryohei Kuwatsuru, Hiroshi Toei, Ryusuke Murakami, Yoshihiko Saito, Atsushi Hirayama, Toyoaki Murohara, Akira Sato, Hideki Ishii, Tadateru Takayama, Makoto Watanabe, Kazuo Awai, Seitaro Oda, Takamichi Murakami, Yukinobu Yagyu, Nobuhiko Joki, Yasuhiro Komatsu, Takamasa Miyauchi, Yugo Ito, Ryo Miyazawa, Yoshihiko Kanno, Tomonari Ogawa, Hiroki Hayashi, Eri Koshi, Tomoki Kosugi, Yoshinari Yasuda, Japanese Society of Nephrology, Japan Radiological Society, and the Japanese Circulation Society Joint Working Group ········· 2572

Letters to the Editor

1. Change in Pericardial Fat Volume and Cardiovascular Risk Factors in a General of Japanese Men (Letter) Manuel Monti, Giuseppe Murdolo, Paolo Diego L’Angiocola, Giovanni Maria Vincentelli ········· 248 2. Identifying Risk Factors for Acute Kidney Injury After Pediatric Cardiac Surgery (Letter) Fu-Shan Xue, Qing Liu, Ya-Yang Liu, Gui-Zhen Yang ········· 493 (Reply) Seon Hwa Lee, Soo-Jin Kim ········· 494 3. Excessive Daytime Sleepiness, Depression and Sleep-Disordered Breathing in Patients With Cardiovascular Disease (Letter) Tomoyuki Kawada ········· 692 (Reply) Mikiko Ohashi, Takashi Kohno, Keiichi Fukuda ········· 693 4. A Concern About 2-Minute Glutaraldehyde-Treated Autologous Pericardium for Mitral Valve Repair (Letter) Naoto Fukunaga, Vivek Rao ········· 946 (Reply) Ken Nakamura, Kazuhiro Hashimoto ········· 947 5. (Retraction Request) Effect of Rosuvastatin on Cholesterol Efflux Capacity and Endothelial Function in Type 2 Diabetes Mellitus and Dyslipidemia (Letter) Soo Lim ········· 948 6. What Determines the Response to Landiolol? (Letter) Daisuke Nitta, Teruhiko Imamura ········· 1617 (Reply) Eiichiro Oka, Yu-ki Iwasaki, Wataru Shimizu ········· 1618

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7. Left Atrial Size and the Risk for Recurrence After Catheter Ablation: Is a Small Left Atrial as Bad as a Large One? (Letter) Jelena Kornej, Philipp Sommer ········· 2185 (Reply) Qiqi Wang, Chengui Zhuo, Liangrong Zheng ········· 2187

Corrigendum 1. Announcement of the 2019 JCS Meeting Activities (2) Toyoaki Murohara ········· 1419 2. Novel Risk Biomarker for Infective Endocarditis Patients With Normal Left Ventricular Ejection Fraction ― Monocyte to High-Density Lipoprotein Cholesterol Ratio ― Xue-biao Wei, Feng Chen, Jie-leng Huang, Peng-cheng He, Yan-xing Wei, Ning Tan, Ji-yan Chen, Dan-qing Yu, Yuan-hui Liu ········· 1420 3. Survey of Palliative Sedation at End of Life in Terminally Ill Heart Failure Patients ― A Single-Center Experience of 5-Year Follow-up ― Yasuhiro Hamatani, Eri Nakai, Emi Nakamura, Michi Miyata, Yukie Kawano, Yasuko Takada, Yuta Anchi, Sayaka Funabashi, Atsushi Hirayama, Kensuke Kuroda, Masashi Amano, Yasuo Sugano, Toshihisa Anzai, Chisato Izumi ········· 2389

Circulation Journal Vol.83, December 2019