CTPS2 Antibody Cat. No.: 56-805

CTPS2 Antibody

Western blot analysis of CTPS2 using rabbit polyclonal CTPS2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CTPS2 gene.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine

This CTPS2 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 450-479 amino acids from the C-terminal region of human CTPS2.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 66 kDa WEIGHT:

September 30, 2021 1 https://www.prosci-inc.com/ctps2-antibody-56-805.html Properties

This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: CTPS2

ALTERNATE NAMES: CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2

ACCESSION NO.: Q9NRF8

PROTEIN GI NO.: 74752919

GENE ID: 56474

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and BACKGROUND: DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

REFERENCES: 1) Kassel, K.M., et al. J. Biol. Chem. 285(44):33727-33736(2010)

2) Olsen, J.V., et al. Cell 127(3):635-648(2006)

3) Han, G.S., et al. J. Biol. Chem. 280(46):38328-38336(2005)

4) Ross, M.T., et al. Nature 434(7031):325-337(2005)

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