elminda introduction February 2019 At a glance
• Multi-disciplinary team, 30% PhDs • 60+ patents • AI and Big data clinical neuro-technology platform • FDA, CE, AMAR, ISO • Paid commercial pilots in the US, Europe & China • HIPAA compliant • Partnershipselminda confidential with information world’s top players Novartis, iKang & Philips The Company - Scientific & Medical Advisory Board
Talma Hendler, MD, PhD Souraski Medical Center, Tel Aviv U. Moshe Bar, MD, PhD, Bar Ilan University Dr. Hendler is the Director of brain imaging center at Tel Aviv Medical Center. Professor, Tel Aviv University (Psychology, Medicine), Director of Tel Aviv Functional Brain Center. Associate Dr. Bar is a neuroscientist, director of the Gonda Multidisciplinary Brain Research Professor, School of Psychological Science, Departments of Physiology and Pharmacology and Center at Bar-Ilan University, associate professor in psychiatry and radiology at Psychiatry, Faculty of Medicine, Sagol School of Neuroscience. Functional Brain Center, Wohl Harvard Medical School, and associate professor in psychiatry and neuroscience Institute for Advanced Imaging, Tel Aviv Medical Center. at Massachusetts General Hospital. He directs the Cognitive Neuroscience Laboratory at the Athinoula A. Martinos Center for Biomedical Imaging. Robert T. Knight, MD PhD, UC Berkeley Leon Y. Deouell, MD, PhD, Hebrew University Dr. Knight is an Internationally renowned leading expert in cognitive neuroscience and Dr. Deouel is the Chair of the Neuropsychology Division at the Hebrew University, neurophysiological analysis. Neurologist and Professor of Psychology and Neuroscience (UC Jerusalem, a senior lecturer at the department of psychology and a member of Berkeley) as well as Neurology and Neurosurgery (UC San Francisco). Director of the Helen Wills the Interdisciplinary Center for Neural Computation at the Hebrew University. Neuroscience Institute at UC Berkeley. He is an internationally acknowledged expert in the neurophysiological analysis of cognitive and emotional processing in humans and the author of Maurizio Fava, MD, Harvard Medical School more than 200 scientific publications. Dr. Fava is Director, Division of Clinical Research of the Massachusetts General Hospital (MGH), Executive Vice Chair of the Department of Psychiatry, Founder Ross Zafonte, MD, Harvard Medical School and Executive Director of the MGH Clinical Trials Network and Institute, Associate Dr. Zafonte is the chairperson of the Department of Physical Medicine and Rehabilitation Dean for clinical and translational research and the Slater Family Professor of (PM&R) at Spaulding Rehabilitation Hospital, Harvard Medical School in Boston and the chief of Psychiatry at Harvard Medical School. Founded and directed the MGH Depression physical medicine & rehabilitation at Massachusetts General Hospital. Dr. Zafonte, D.O. is Clinical and Research Program, one of the most highly regarded depression known for his work in traumatic brain injury and is recognized as an expert in his field. He is the programs in the country. He has edited eight books and authored or co-authored author of more than 300 peer review journal articles, abstracts and book chapters. more than 900 original articles. John M. Zajecka, MD, Rush University Adam Gazzaley, MD, PhD, UC San Francisco Dr. Zajecka is Associate Professor of Psychiatry and Clinical Director of the Depression Dr. Gazalley is a neuroscientist, author, photographer, entrepreneur and inventor. Treatment and Research Center at Rush University Medical Center in Chicago and Skokie, He is the founder and executive director of Neuroscape and Professor of Illinois. He has authored numerous publications and conducted research in affective disorders, Neurology, Physiology, and Psychiatry at University of California, San Francisco. anxiety disorders and schizophrenia and serves on the scientific advisory boards for the He is also co-founder and Chief Science Advisor of Akili Interactive Labs and JAZZ National Depression and Bipolar Support Alliance and the American Foundation for Suicide Venture Partners. He has authored over 130 scientific articles. Prevention, as well as for several pharmaceutical companies. elminda confidential information Brain Networks Analytics (BNA™) in 90 sec
elminda BNA in 90 seconds link
elminda confidential information BNA™ – Brain Networks Analytics Analyzing & Corelating Brain Function
Today Tomorrow
BNA™ Anatomy, Behavior, Perfusion, Metabolism, Genetic Symptoms
Genetic MRI, CT, PET, Interviews & other imaging behavioral tests
5 elminda confidential information BNA™ - a cloud based software service How it Works
BNA™
1 2 3 12-40 minute non-invasive Uploaded to the cloud and Actionable physician & standard EEG recording while automatically validated, consumer/patient report, evoking specific brain functions cleaned & analyzed accessible on-line
6 elminda confidential information The essence of BNA™
Clean electrical data
Rich demographic and clinical data
Standardization and harmonization
Drawing from large knowledge-base of publications
Interpretation using advanced AI tools
7 elminda confidential information Big Database Elminda’s Significant Competitive Advantage
450000 • > 425,000 datasets – the largest 400000 database of brain neuronal functions and clinical information 350000
300000 • Continuously grows with every new Colors represent variety test performed 250000 of brain functions
200000 • Includes individuals aged 12-85, healthy and pre-diagnosed with 150000
specific brain related disorders 100000
• Projected to grow to over 1 million 50000
datasets by mid 2020 0 2010 2011 2012 2013 2014 2015 2016 2017 2018
8 elminda confidential information BNA™ provides a comprehensive brain health platform solution Market- specific applications development through partnerships
BNA brain checkup New treatment development Screening of potential abnormalities Pharma and therapeutics partnerships Brain Wellness PREVENT
Brain Disorders Big Braindata lake &Networks artificial BNA Biomarkers Early detection of intelligenceAnalytics specific disorders (e.g. dementia) TREAT PREDICT
Treatment Analytics Improve your treatment management options
Treatment selection treatment selection & optimization elminda confidential Distributioninformation Partner Using BNA for brain function checkup The Villages Health System, Florida, U.S.
• World’s largest older adult community with 140,000+ people • Collecting the largest longitudinal database of normal & abnormal aging brains - Over 1,000 individuals signed up, out of 1,365 - Operating 5 BNA labs - 2 years study Carla VandeWeerd PhD, • Developing lifetime brain health Mitch Roberts MA, management service offering Erica Sappington MA, Ali Yalcin PhD, Jeff Lowenkron MD, John Castaldo MD, Elliot Sussman MD Elminda’s brain function checkup Actionable Brain Wellness Testing
• 15 minute electrophysiological test of fundamental brain functions • Based on evidence from > 10,000 • Objectively detects brain function scientific publications abnormalities as compared to matched age-gender database
11 elminda confidential information The Villages Health Initial Results for modeling memory function with BNA
Memory model Age = 50-85 n (normative cognition) = 625 (76 validation) n MCI = 8 n EAD = 6 ICC = 0.77 r = 0.68, p<0.001
Normal Validation
Winner of The Aging Award for Excellence in Research by the American Public Health Association (APHA) Model Accuracy – classifier healthy and memory impaired
ROC curve
Sensitivity = 93% Only 14 patients… Specificity = 85% Memory composite score over time 2 transition cases (out of 4)
Baseline Week 6 months Year
Baseline Week 6 months Year Case Example #1 – normal function
Age: 42 Gender: Female Underling Health Conditions: • Hypothyroidism • No reported symptoms Additional Information: • Exercises regularly Actionable Recommendations: Exercise – Aerobic exercise at least 3 times a week for at least 30 minutes Healthy Diet – A balanced diet rich in fruits and vegetables, specifically a Mediterranean diet Sleep – 7 to 8 hours of quality sleep is recommended per night
Brain functions within norm Hypothyroidism in control not affecting brain function Annual follow-up
15 elminda confidential information Case Example 1 – early detection of a memory problem
Age: 64 Gender: Male Underling Health Conditions: • Hypertension, elevated cholesterol, obesity Reported Symptoms: • Feels fatigued at times
• Sometimes feels forgetful Actionable Recommendations: Referral to Neurologist Blood tests – TSH, B12, A1C, Lipid Profile MOCA or MMSE
Functions out of norm BNA identifies someone possibly at risk for significant brain disease and is able to refer them for further evaluation with a specialist
16 elminda confidential information 1 in 3 cases of Dementia could be prevented!
Lancet Commission of Dementia Prevention & Care 2017
elminda confidential information Brain function checkup - next Steps • Use BNA part of annual wellness check-ups • Improve wellbeing and quality of life • Enhance performance and cognitive skills • Increase compliance in comorbidity cases • Early detection of cognitive decline A Recognized Leader In Transformation of Brain Function Measurement
elminda is Often Selected to Showcase Breakthrough Innovation to World Leaders
Shaping the future of brain health today.
International Recognition for Pioneering Innovation
19 elminda confidential information