Index Aberrations Anticoagulants , 56 , 59 , anaphase , 155 , 160 , 60 , 66 161 , 165 Antipyrine , 63 See also individual tables for further behavioral , 49 Aquinas , 210 listing of drugs of abuse chromosome , 27 , 33 , 38 - Aristotle , 210 39 , 49 - 50 , 113 - 115 , Aromatic amines , 81 - 83 , 118 , 120 , 122 , 140 - 85 141 , 148 , 154 , 158 - Aromatic hydro carbons , 159 , 162 - 164 , 171 , 81 , 82 , 85 200 Arsenic , 82 , 90 psychiatric , 209 Asbestos , 82 Acetanilide , 57 , 59 , 67 , 69 Ascorbic acid . 4 . 58 . Acetazolamide , 55 61 . 63 Acetophenetidin ,59 Aspergillus nidulans , 131 2-Acetylaminofluorene . Aspirin . 59 . 149 , 165 58 . 81 . 20 . 21 . 56 . Acetylcholine , 56 67 . 214 N'-Acetyl LSD , 18 poisoning . 67 Actinomycin D, 59 Atroscine . 21 Acts aggressive , 35 , 48 , 214 Banisteriopsis . 22 suicidal , 214 . 19 , 29 , 33 , 35 , Adenine , 122 , 128 , 48 . 49 . 54 - 60 , 63 , 87 , 132 , 1 33 , 174 213 - 216 . 223 Adiphenine , 68 interactions , Adrenochrome or Adreno - 36 . 54 - 55 lutin theory , 47 analogs . 49 Aflatoxins , 81 , 192 animal effects . 94 Alcohol , 28 , 33 , 35 , 54 - Baudelaire , 213 55 , 213 - 216 Bellevue Psychiatric Alcoholics Anonymous , Hospital . 36 217 , 20 Alcoholism , 35 , 36 , 49 Benzaldehyde , 124 ALD - 52 , 18 Benzedrine , 19 Alkylating agents , 82 - 85 , . 91 , 155 122 , 172 , 179 , 192 3. 4 - Benzpyrene , 58 . American Medical Association 61 . 88 (AMA ) , 38 Bishydroxycoumarin , 66 4 -Aminoantipyrine , 63 Breakage Aminoazo dyes , 57 , 58 , chromosome . xi . 114 , 64 , 81 121 , 131 , 137 - 138 , 2 -Aminopurine , 122 145 . 148 - 149 . 152 - p -Aminosalicylic acid , 65 166 , 196 , 197 Aminopyrine , 60 , 63 - 65 delayed isolocus . 160 - Ammonium chloride , 55 161 Amobarbital (" Blue isochromatid , 160 Heaven " ) , 19 , 60 Brodie -Axelrod hypothesis Amphetamine , 19 , 21 , 29 , . 46 31 , 33 , 35 , 36 , 46 , 47 , Bromides . 214 49 , 66 , 67 , 71 , 148 , 5 - Bromouracil . 122 211 , 214 , 215 , 223 Butabarbital , 60 analogs , 19 , 20 animal effects , 46 , 94 Caffeine , 165 , 192 metabolism , 46 California , 29 , 31 - 36 AMT , 47 Department of Education Analgesics , 29 , 57 , 58 , 33 , 49 , 56 , 69 Department of Public Anesthetics , 22 , 58 Health , 33 euphoric , 214 Haight -Ashbury , 35 Anhalonium lewinii , 21 Los Angeles , 33 Antacids , 54 San Francisco , 29 , 35 , 38 Anticholinergics , 48 , 66 , San Mateo County , 33 67 Cannabichromene , 17 INDEX225 Cannabicyclol , 17 . 91 . 155 D D D . 60 139 , 152 - 156 , 194 Cannabidiolic acid , 17 Chlorpromazine DDE . 60 Drug offenders , juvenile , Cannabidivarin , 17 animal effects . 60 . 65 , DDT . 60 29 Cannabigerol , 17 69 . 94 . 195 Decontrol . 216 - 217 Drugs Cannabigerolic acid , 17 human effects . 145 . Deletions . chromosomal . effects , 27 Cannabinol , 4 , 48 152 . 154 122 . 130 . 132 - 137 , nonaddictive , 29 Cannabinolic acid , 17 Chlorpropamide . 66 158 - 159 physically addicting , 29 , Cannabis , 17 , 214 , Cholestyramine . 54 end . 1 20 49 215 , 217 Choline . 56 internal . 161 psychotherapeutic , 31 Cannabis sativa , 17 Cholinergic . 56 terminal . 158 . 161 Carbamides , 68 Chromate . 82 Demerol . 67 Effects , of drug abuse Carbon monoxide , 65 Chromosomal abnor - Depressants . 35 . 54 acute health , 27 - 28 , Carbon tetrachloride , 91 malities . 50 Descartes . Rene . 210 37 , 39 Carcinogenesis , 39 , 79 acentric . 141 . 160 . 161 Deserpidine . animal chronic health , 27 - 28 , 37 chemical , 27 - 28 , 37 , 57 , breaks . see Breakage . effects . 94 delirium , 216 80 - 92 , 176 chromosome DET . 21 . 46 depressant 46 , 49 viral , 79 - 84 , 165 dicentric . 141 . 1 56 Dexamphetamine . 66 dose - related , 37 Carcinogenicity testing . 161 . 166 Dexedrine . 19 economic , 35 82 - 89 exchange figures . 141 Dextroamphetamine . 66 hallucinogenetic , 35 implantation . 86 . 89 gaps . 160 . 163 . 69 inductive , 58 , 71 , 87 : 224 inhalation . 88 quadriradial . 145 Dialkylindolylethanola - physiological , 49 intramuscular . 89 ring chromosomes . 141 . mine . 21 social , 35 , 49 intraperitoneal , 86 , 89 156 . 161 N.N - dialkyltryptamine . 21 teratogenic , 93 - 95 , 11 0- intravenous . 86 . 88 . 89 Chromosomes . 154 111 , 118 - 119 oral , 85 . 87 , 88 marker . 156 . 161 1 . 2 . 5 . 6 - Dibenzanthra - Elemicin , 21 subcutaneous . 82 . 85 . Muller - 5 . 137 cene . 58 Enovid , 38 87 , 89 Claviceps purpurea . 18 2 - Diethylaminoethyl 1- 2. Ephedrine , 19 , 67 , 214 topical . 85 . 88 , 89 Cocaine . 19 . 148 . 213 - 2- Diphenylvalerate . Epinephrine , 46 , 49 , 66 Carcinogens . 79 - 84 216 See SKF 525A . Ergonovine , 18 , 149 aliphatic . 83 . 66 . 124 Digitalis . 55 Ergotoxine , 18 aromatic . see Aromatic Colcemid . 155 . 162 . 171 Digitoxin . 60 Ether , 211 hydro carbons Colchicine . 122 . 155 . Di - isopropylamine . 21 Ethinamate , animal chemical , 80 . 81 161 - 162 effects , 94 DNA viruses . 79 Congenital malformations See Tetrahydrocan - Ethionine , 59 RNA viruses . 84 93 . 116 nabinol Ethyl isocyanide , 65 viruses . 79 . 80 Convovulaceae . 18 Dimethylnitrosamine . N- ethyl LSD , 18 Cardiac malformations . 94 Corticosteroids . 55 172 . 176 Ethyl methanesulfonate , Carisoprodal . 65 Coumarin . 60 2. 5- Dimethoxy - 4 - 156 , 175 , 179 Catecholamine . 47 . 55 . 66 effects . 55 . 66 methyl -B - nitrophenyl - Ethyl , 66 Catnip . 22 Cri - du -chat syndrome , propene . 20 N -demethylation , 64 , Cell 158 Diphenylhydantoin . 60 . 65 , 67 aneuploid . 122 . 155 . 159 Croton oil . 85 - 86 64 - 66 Euphoria , 214 diploid . 113 . 120 . 133 . Cyanide . 122 Dipropylamine , 21 Existentialism , 210 135 . 154 . 162 . 166 Cycasin . 81 . 176 Dipyrone , 63 germ . 116 , 121 , 155 . . 20 Disipal , 154 Facial malformations , 94 156 Cyclohexylamine . xi . 192 Disorders Fetal abnormalities , 27 , monosomic . 11 3 , 114 Cydril . 19 character , 213 110 , 121 polyploid , 113 . 122 , 154 , Cytochrome P- 450 . 57 . psychiatric , 214 , 216 Flupenthixol , 94 155 . 159 59 . 60 . 64 - 65 , 66 Fluphenazine , 94 , 154 polysomic . 113 Cytosine . 122 , 48 somatic , 114 . 155 . 156 , Cytoxan . 192 DMT , 21 - 23 , 46 Galactose metabolism , 63 158 . 166 . 197 . 200 DNA , 114 , 120 - 124 , 152 , Gallup poll , 31 trisomic . 11 3 . 114 . Damage 155 - 161 , 192 Genes 11 5 . 1 56 chromosome . 113 . 140 . DaM , 20 , 23 , 46 , 124 , C , 128 Chloral hydrate . 59 . 60 149 . 177 - 178 See also SIP marker , 138 , 205 Chloramphenicol , 38 cytogenetic . 11 3. Dominant lethal assay , mutant , 115 - 117 Chlorcyclizine . 66 118 - 119 164 , 177 - 181 , 192 - normal , 11 5 Chlordane . 60 genetic . 113 . 140 . 177 . 195 , 197 recessive , 117 , 94 197 . 199 DOPA , 68 Genetic death , 118 , 156 human effects . 154 organic . 210 Down 's syndrome Glucose metabolism , 56 Chlorguanide . 59 prenatal . 93 See Mongolism Glue , 88 , 214 Chlorinated hydro carbons . Darvon . 20 Drosophila . melanogaster , Glutethimides (" Cibas " ) , 68 Day top Village . 217 11 5 , 117 - 118 , 1 36 - 19 , 60 INDEX 226 Glutethimides (cant .) LAE - 32 , 18 Methylazoxymethanol , recessive , 117 . 120 . 132 - animal effects , 66 , 94 Lens defects , 94 176 134 . 136 - 137 . 201 - Gramine , 46 , 47 Levamfetamine , 19 3 - Methylcholanthrene , 202 , 205 Griseofulvin , 60 , 69 57 - 65 semilethal . 156 - 157 Guanethidine , 55 Librium . See 3- Methyl -4 - dimethylam - severe , 11 5 , 117 . Guthion , 59 Chlordiazepoxide inoazobenzene , 57 121 , 157 Lindane , 60 Methylenedioxybenzenes , somatic , 114 . 121 . 196 Hallucinations , 214 68 LSD , 3 , 18 , 20 , 23 , 29 , spontaneous . 115 . 117 . , 31 , 35 - 36 33 , 36 , 122 , 196 Methylenedioxyphenyl 157 . 165 . 205 . 206 effects , 46 - 49 , 213 - 214 , butyl . dimethyl , methyl . compounds . 68 , 21 217 , 223 propyl . 18 3- Methyl - MAB ( methyl - , 94 effects . 1 62 . 1 64 aminoazobenzene ) , 64 Nalline . 56 Harma /a , 22 animals . 45 - 46 . 94 . Methylphenidate , 36 . 56 Hashish , 4 114 . 122 . 138 . 149 . animal effects . 94 Napa State Hospital . 36 Hemophilia , 118 , 202 - 203 1 52 . 1 54 a - Methyltryptamine , 94 2 - Naphthylamine . 81 Heptabarbital , 60 humans . 4 . 18 . 23 . 47 , Michaelis constant , Natural selection . 115 , 20 , 31 , 33 , 54 , 49 . 141 . 145 - 149 , 65 , 69 - 70 Neoplasms 212 , 215 154 . 212 - 217 . 223 - Microsomal enzymes , benign . 79 . 89 Hexobarbital , 60 , 63 224 induction , 56 - 65 , 87 , induced . 79 - 92 . 122 metabolism , 60 , 65 - 70 LSM - 777 . 18 171 - 172 , 181 , 224 malignant 79 . 85 . 89 Host - mediated assay , 127 , Lysergic acid . 18 inhibition , 59 , 65 , 68 , sarcomas . 82 . 89 134 - 135 , 164 , 171 70 , 110 skin . 80 - 81 . 86 . 88 173 , 175 , 192 , 194 Malformations , 27 , 39 , 93 , Mill , John Stuart , 217 spontaneous . 79 . 158 . Huntington 's chorea , 203 110 , 118 , 121 , 193 Mitosis , 114 , 155 , 162 , 165 , 123 - 124 MAD inhibitors , effects , 164 Nervous system . 50 . 66 , 123 - 124 66 - 70 , 94 MLD - 41 , 18 parasympathetic . 20 . 68 5- Hydroxyindoleacetic Marijuana MMS (methyl methane - sympathetic . 19 . 45 - 47 . acid ( HIAA ) , 47 animal effects . 48 . sulfonate ) , 175 , 192 66 . 68 Hy oscine . See Scopola - 88 . 94 Mongolism , 38 , 114 , Neurospora crassa . 130 - mine human effects . 4 . 23 . 29 . 11 6 , 1 55 135 . 156 . 173 . 175 . See 33 . 48 - 49 . 71 , 148 , Monism , hierarchical , 210 Nialamide . 67 Atropine 152 , 212 , 223 Morphine , 49 , 67 Nitrogen mustard , 178 , 6.8- Hydroxycortisol , MDA , 19 , 46 , 124 animal effects , 68 - 69 , 179 60 , 64 Medazepam , 154 94 , 124 , animal Hypnotics , 36 , 45 , 58 , 68 Meiosis , 114 , 116 , 137 , plant effects , 122 effects , 94 152 . 155 , 159 , 162 , Muller , H . J ., 118 , , 22 Nobrium , 154 165 , 192 1 37 , 138 , 46 , 67 , 69 Mellaril . 154 Mutagenesis , 27 , 37 , 39 , animal effects , 46 , 66 , 94 Norephedrine , 66 Mendelian inheritance , 91 , 176 Indolealkylamines , 46 Norepinephrine , 46 , 114 - 116 Mutagens , 83 , 118 , 122 , 55 - 66 , 68 Indole compounds , 47 Mental disease . 116 , 210 128 , 135 - 136 , 152 , Infertility , 179 . See also Nutmeg , 21- 22 Meperidine . toxicity , 67 164 , 171 - 172 , 177 - Sterility Mephobarbital , 59 178 , 206 Octamethyl pyrophos - Interactions , drug . See , 60 , 65 Mutation phoramide . See Metabolism , drug animal effects . 66 . 69 , chromosome , 11 5- 11 6 , Schradan . Intoxicants , 21 94 , 124 121 - 122 , 135 , 178 Ololiuqui , 18 Intoxication , pathological , . 19 , 20 , 21 , 94 , dominant , 117 - 121 , 156 , 214 , 20 , 29 , 36 , 55 - 124 , 212 177 , 203 56 , 212 , 213 , 215 , 217 Inversions , 137 , 138 Metabolism effects , 11 5 , 118 , 120 - Ipomoeae , 19 drug . 53 - 60 121 , 124 , 201 Iproniazid , 67 addiction , 29 , 67 , 211 , microsomal . 56 - 67 gene , 113 , 11 5- 117 , 215 Iso - lysergic acid , 18 tests for measuring induction 120 - 121 , 127 - 128 , , 55 Isoniazid , 65 - 66 , 57- 69 130 , 132 , 156 , 199 , 154 Isopropamide , 67 METEPA . 192 induced , 117 , 127 - 128 , Overmedication , 54 , 56 , Iso - tetra hydrocan na - , 223 130 60 , 211 binol , 18 Methamphetamine . 19 , lethal , 115 , 117 , 120 - Oxotremorine , 59 Kaiser - Permanente 31 , 36 , 66 , 211 , 215 121 , 130 - 137 , 156 - inhibition of , 66 Medical Group , 38 Methaqualone , animal 157 , 177 , 201 - 202 , Kelthane , 60 effects . 94 205 Pamaquine . 55 , 20 Metharbital . 65 mild , 115 - 121 , 157 . See Tetrahy - Khat 19 Methedrine , 19 point 114 - 122 , 132 . drocannibinol Methotrexate , 54 135 , 156 , 175 , 179 . Parasympatholytic . 20 . 68 Lactose, 4 Methoxychlor , 60 198 Parathion . 68

INDEX 227 Pemoline , 94 psychiatric , 214 - 216 Streptonigrin . 149 Thalidomide . 95 . 152 . 198 , 20 toxic , 49 Streptozotocin . 172 Thiazides . 55 ("yellow " ) , Registry on Adverse ReactionsStrychnine . 4. 65 Thioridazine . 154 19 , 65 , 66 , 69 , 38 Suicide . 211 . 214 . 217 TMA . 46 Permitol , 94 , 1 54 Reproductive effects , 93 . Sulfonamides . 54 Tobacco . 28 . 43 Perphenazine , 154 See also Mutagenesis ; Sulfonylureas . 54 Tolbutamide . 54 . 66 Personality studies , 212 Teratogenesis Sulphaphenazole . 66 glue . 214 Perthane , 60 Reserpine , 55 Surveil lance approach . Toronto . 35 Peyote , 21 , 23 animal effects , 94 39 . 42 Tranquilizers . xii . 29 . 31 . Pha !aris arundinacea , 46 Retardation , 116 - 118 Sweden . 28 . 36 . 212 . 215 36 . 58 . 94 . 1 52 . 1 54 . Pha !aris tuberosa , 46 Ritalin , 36 , 94 Sympathomimetic . 19 . 195 Phenaglycodal , 66 Rubella virus , effects on 45 - 47 . 66 . 68 Translocation , 20 chromosome damage , Synanon . 217 effects , 114 , 116 , 120 , , 20 122 , 149 Synergists . 86 . 192 136 - 138 , 152 , 156 , Phenelzine , 66 - 67 insecticidal . 68 177 - 180 , 193 , 197 Phenethylamines , 45 - 46 Saccharomyces cerevi - Tranylcypromine , 67 Phenmetrazine , 36 siae . 195 , 22 Tremorine , 59 , 66 {" purple Safrol . 21 Tabernanthine , 22 Trenimone , 179 , 192 hearts " ) , 59- 69 Salicylamide . 60 Talwin , 20 Triavil , 1 54 Phenols , 124 Salicvlates . 54 TEM , 179 Trimethadione , 65 Phenotypes , mutant , 115 , Salmon ella typhimurium , T emporo -spatial Trimethylphosphate , 192 120 , 131 - 132 , 196 , 128 strategy , 27 Triparanol , 69 198 , 203 , 205 mutant , 172 - 175 TEPA , 178 - 180 , 192 Tryptamine , 45 - 47 Phenyl acetone , 19 Sansert , 18 Teratogenesis , 27 , 93 , homologs , 46 , 47 Phenylbutazone , 54 , Schizophrenia , 36 , 47 121 - 122 , 165 , 198 Tuinal (rainbow " ) , 19 59 - 66 paranoid , 216 Teratogenicity , 37 , 39 , 91 , Tumors . See Neoplasms . Phenylisopropylamine . typical , 216 93 - 95 , 110 - 111 , 140 Tyramine , 66 , 68 See Amphetamine . Schradan , 59 Testing Phenylisopropyl hydrazi ne, , 21 , 122 , carcinogenicity , 37 , 38 , Urethan . 86 66 124 79 - 83 , 192 , 193 , 223 {3- Phenylisopropylhy - Scotch broom , 22 cytogenetic , 120 , 140 - Valium . 154 drazine , 67 Secobarbital (" reds " ) , 141 , 145 , 148 - 149 , Valnoctamide . 94 Phenylpropanolamine, 67 19 , 60 1 52 - 1 66 , 177 , 192 - Vitamin K. 56 Phenyramidol , effects , 66 Sedatives , 19 , 29 , 31 , 36 , 193 , 197 , 200 Vitamins . 63 Piperonyl butoxide , 68 45 , 58 , 68 , 213 microbial , 127 , 128 , Pipradols , animal bromides , 214 130 - 136 , 194 , 199 Withdrawal , 56 , 212 , 213 , effects , 94 Sernyl , 20 mutagenicity , 37- 38 , 83 , 215 , 216 Plant essential oils , 21 analogs , 20 124 , 127 , 128 - 141 , Polycyclic hydro carbons , Serotonin , 47 , 66 145 , 148 - 149 , 152 , X - irradiation , 178 - 179 , 58 , 63 - 65 , 81 , 86 , 89 SKF 525 - A , 68 154 - 166 , 171 - 181 , 192 Preludin , 36 Snuff , 21 , 46 192 - 203 , 205 - 206 , Primidone , 59 Sodium bicarbonate , 55 223 - 224 Zoxazolamine , 60 , 65 , 69 Prinadol , 20 Solanaceae , 21 teratogenicity , 37- 38 , Probenizid , 55 Solvents , 91 - 95 , 110 - 111 , Prochlorperizine , 94 volatile , 36 192 - 193 , 223 - 224 Prolix in , 94 , 154 Specific hypothesis Testosterone , 69 Prontosil , 59 testing , 39 Tetracyclines , 54 Propoxyphene , 20 Spironalactone , 56 Tetrahydrocannabinoid , , 22 , 46 , 94 Sterility , 177 - 180 , 193 17 Psilocybe baeocystis , 22 semisterility , 178 - 180 , Psilocybe mexican a, 22 193 (THC ) . 17 . 18 . 23 . 45 . , 22 , 46 , 212 Stimulants , 29 , 31 , 35 - 36 , 48 . 70 . 223 Psychiatry , 209 - 218 46 , 48 , 213 , 214 A 1- 3. 4 -trans - Tetrahydro - Psychic contagion , 209 , amphetamine , 46 , 54 cannabinol . 17 211 cocaine , 46 , 54 A 1 ( 6) - 3. 4 - trans - Tetra - Puromycin . 59 ephedrine , 214 hydrocannabinol . 17 Pyrrolizidine alkaloids . 81 methamphetamine , 46 , A3- Tetrahydrocannabinol . 215 17 Quinacrine . 54 St , Louis , Missouri , 35 A 1- Tetrahydrocanna - Stockholm , Sweden , 36 binolic acid . 17 Reactions STP . See DaM . Tetrahydrocannabitriolyl nonpsychiatric , 27 , 42 , analogs , 21 carboxy - 49 Stramonium , 214 late . 17 INDEX228