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2014-02-05 Gene Expression Study Of Mycobacterium avium subspecies paratuberculosis Infected Cows – “A road to identify transcripts that could serve as biomarkers for early diagnosis of Johne’s disease”

David, Joel

David, J. (2014). Gene Expression Study Of Mycobacterium avium subspecies paratuberculosis Infected Cows – “A road to identify transcripts that could serve as biomarkers for early diagnosis of Johne’s disease” (Unpublished master's thesis). University of Calgary, Calgary, AB. doi:10.11575/PRISM/26265 http://hdl.handle.net/11023/1368 master thesis

University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca List of canonical pathways associated with differentially expressed genes at 6 months after infection © 2000-2013 Ingenuity Systems, Inc. All rights reserved. Ingenuity Canonical Pathways -log(p-value) Ratio Molecules Superpathway of Inositol Phosphate Compounds 3.88E00 9.65E-02 ACP5,CCR1,WBP11,PIK3CA,MTMR9,PTPN2,NUDT9,ITPKA,PPM1K,PTPN12,NUDT15,UBLCP1,SACM1L,MTMR6,PTPRC,IP6K3,INPP5F,NUDT11,PDCD1,DUSP10,IP6K1,RASA1 D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis 3.55E00 1.14E-01 ACP5,WBP11,MTMR9,PTPN2,NUDT9,PPM1K,PTPN12,NUDT15,UBLCP1,SACM1L,MTMR6,PTPRC,PDCD1,NUDT11,DUSP10,RASA1 D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis 3.55E00 1.14E-01 ACP5,WBP11,MTMR9,PTPN2,NUDT9,PPM1K,PTPN12,NUDT15,UBLCP1,SACM1L,MTMR6,PTPRC,PDCD1,NUDT11,DUSP10,RASA1 D-myo-inositol-5-phosphate Metabolism 3.39E00 1.08E-01 ACP5,CCR1,WBP11,MTMR9,PTPN2,NUDT9,PPM1K,PTPN12,NUDT15,UBLCP1,SACM1L,PTPRC,MTMR6,PDCD1,NUDT11,DUSP10,RASA1 3-phosphoinositide Degradation 3.35E00 1.08E-01 ACP5,WBP11,MTMR9,PTPN2,NUDT9,PPM1K,PTPN12,NUDT15,UBLCP1,SACM1L,MTMR6,PTPRC,INPP5F,PDCD1,NUDT11,DUSP10,RASA1 Protein Ubiquitination Pathway 3.34E00 9.7E-02 HLA-A,UBE2V2,Ubb,DNAJA1,USP3,HSP90AB1,PSMC6,USP47,USP16,DNAJC1,UCHL5,UBE2J1,BIRC3,AMFR,USP28,IFNG,USP15,DNAJC27,USP38,HSPH1,UBD,NEDD4,PSMB2,HSPB11,HSP90AA1,USP34 Arginine Degradation I (Arginase Pathway) 3.32E00 2.31E-01 OAT,ARG2,ARG1 Estrogen Receptor Signaling 3.23E00 1.18E-01 MED13,PRKDC,MED23,GTF2F2,GTF2H2,KRAS,MNAT1,SMARCA4,MED27,POLR2L,KAT2B,DDX5,RRAS2,MAP2K2,TAF5,GTF2E1 3-phosphoinositide Biosynthesis 2.96E00 9.66E-02 ACP5,WBP11,PIK3CA,MTMR9,PTPN2,NUDT9,PPM1K,PTPN12,NUDT15,UBLCP1,SACM1L,MTMR6,PTPRC,PDCD1,NUDT11,DUSP10,RASA1 Arginine Degradation VI (Arginase 2 Pathway) 2.65E00 1.88E-01 OAT,ARG2,ARG1 Antiproliferative Role of Somatostatin Receptor 2 2.41E00 1.27E-01 PIK3CA,RRAS2,MAP2K2,GNB5,KRAS,GNG2,GNB1L,GNG7,GUCY1B3 Citrulline Biosynthesis 2.24E00 1.15E-01 OAT,ARG2,ARG1 JAK/Stat Signaling 2.23E00 1.29E-01 STAT4,PIAS3,MTOR,PIK3CA,RRAS2,MAP2K2,PIAS1,KRAS,SOCS4 Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency 2.18E00 1.56E-01 CASP6,PCGF6,FAM208A,FOXA2,RARA,NR2F6,NR5A1 L-serine Degradation 2.14E00 3.33E-01 SDS,SDSL Prostate Cancer Signaling 2.12E00 1.02E-01 MTOR,PIK3CA,RRAS2,MAP2K2,FOXO1,HSP90AB1,HSP90AA1,KRAS,CTNNB1,ATF2 Renal Cell Carcinoma Signaling 2.1E00 1.22E-01 UBD,MET,PIK3CA,RRAS2,MAP2K2,PAK6,Ubb,KRAS,RAP1A Valine Degradation I 1.97E00 1.14E-01 HIBCH,DBT,SDS,HADHA FLT3 Signaling in Hematopoietic Progenitor Cells 1.95E00 1.18E-01 STAT4,MTOR,PIK3CA,RRAS2,MAP2K2,RPS6KA3,KRAS,MAPK12,ATF2 Dolichyl-diphosphooligosaccharide Biosynthesis 1.94E00 7.69E-02 ALG6,ALG1,DPM2 Hereditary Breast Cancer Signaling 1.88E00 9.38E-02 UBD,POLR2L,PIK3CA,FANCM,RRAS2,MSH2,HDAC7,Ubb,KRAS,ATR,FANCL,SMARCA4 Thyroid Cancer Signaling 1.86E00 1.43E-01 CXCL10,RRAS2,MAP2K2,KRAS,TCF7L1,CTNNB1 Acute Myeloid Leukemia Signaling 1.84E00 1.1E-01 CSF3R,MTOR,PIK3CA,RRAS2,MAP2K2,RARA,KIT,KRAS,TCF7L1 Angiopoietin Signaling 1.82E00 1.08E-01 PTK2,PIK3CA,RRAS2,FOXO1,PAK6,KRAS,IKBKAP,RASA1 UVC-Induced MAPK Signaling 1.76E00 1.43E-01 RRAS2,MAP2K2,KRAS,MAPK12,SMPD3,ATR HMGB1 Signaling 1.75E00 1.01E-01 KAT2B,IFNG,PIK3CA,RRAS2,AGER,MAP2K2,HAT1,RBBP7,KRAS,MAPK12 Cleavage and Polyadenylation of Pre-mRNA 1.71E00 2.5E-01 CPSF2,PAPOLA,CPSF6 Polyamine Regulation in Colon Cancer 1.66E00 1.38E-01 PSMF1,PSME4,KRAS,CTNNB1 IGF-1 Signaling 1.64E00 9.52E-02 PTK2,PIK3CA,NEDD4,RRAS2,MAP2K2,FOXO1,IGF1R,KRAS,SOCS4,RASA1 Salvage Pathways of Pyrimidine Ribonucleotides 1.62E00 8.82E-02 CDK18,NME1,MAP2K2,PRPF4B,UPP1,GRK6,UCK1,NME7,NME6 PI3K Signaling in B Lymphocytes 1.58E00 8.57E-02 PTPRC,PIK3CA,RRAS2,CAMK2D,MAP2K2,CD180,DAPP1,CARD10,KRAS,PLEKHA4,PLCL1,ATF2 IL-17 Signaling 1.57E00 1.08E-01 CXCL10,PIK3CA,RRAS2,MAP2K2,KRAS,MAPK12,IL17A,ATF2 B Cell Receptor Signaling 1.57E00 8.24E-02 PIK3CA,KRAS,MAPK12,ATF2,PTPRC,MTOR,RRAS2,CAMK2D,MAP2K2,FOXO1,INPP5F,DAPP1,CARD10,BCL2A1 Nucleotide Excision Repair Pathway 1.54E00 1.43E-01 POLR2L,ERCC4,GTF2H2,MNAT1,RAD23B Ephrin B Signaling 1.54E00 9.88E-02 PTK2,ITSN1,GNB5,GNG2,GNB1L,CTNNB1,GNG7,HNRNPK Role of BRCA1 in DNA Damage Response 1.53E00 1.08E-01 FANCM,MSH2,UIMC1,BRCC3,ATR,FANCL,SMARCA4 FAK Signaling 1.53E00 8.82E-02 PTK2,PIK3CA,RRAS2,CAPNS1,MAP2K2,PAK6,HMMR,KRAS,GIT2 Superpathway of Citrulline Metabolism 1.52E00 7.89E-02 OAT,ARG2,ARG1 Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I 1.52E00 8.82E-02 NME1,NME7,NME6 IL-15 Signaling 1.5E00 1.04E-01 PTK2,PIK3CA,RRAS2,MAP2K2,KRAS,MAPK12,IL17A Eicosanoid Signaling 1.5E00 8.75E-02 ALOX15,DPEP1,ALOX5AP,PTGDS,ALOX5,TBXAS1,PTGER4 Urea Cycle 1.49E00 1E-01 ARG2,ARG1 Acetyl-CoA Biosynthesis I (Pyruvate Dehydrogenase Complex) 1.49E00 1.82E-01 DLAT,DBT Role of NFAT in Cardiac Hypertrophy 1.44E00 7.25E-02 PIK3CA,GNB5,KRAS,MAPK12,GNG7,CAMK2D,RRAS2,MAP2K2,HDAC7,TGFB2,IGF1R,GNG2,PLCL1,SLC8A1,GNB1L Assembly of RNA Polymerase II Complex 1.43E00 1.07E-01 POLR2L,TAF5,GTF2E1,DR1,GTF2H2,MNAT1 Granzyme B Signaling 1.37E00 1.88E-01 PRKDC,PRF1,LMNB2 PI3K/AKT Signaling 1.36E00 7.64E-02 MTOR,RHEB,PIK3CA,RRAS2,MAP2K2,FOXO1,INPP5F,HSP90AB1,HSP90AA1,KRAS,CTNNB1 CNTF Signaling 1.35E00 1.09E-01 MTOR,PIK3CA,RRAS2,MAP2K2,RPS6KA3,KRAS Inositol Pyrophosphates Biosynthesis 1.35E00 1.25E-01 IP6K3,IP6K1 SAPK/JNK Signaling 1.34E00 8.82E-02 PIK3CA,RRAS2,DUSP10,KRAS,GNG2,MAPK12,GNG7,HNRNPK,ATF2 Role of MAPK Signaling in the Pathogenesis of Influenza 1.34E00 1.01E-01 CXCL10,IFNG,RRAS2,MAP2K2,KRAS,MAPK12,ATF2 Thiamin Salvage III 1.3E00 2E-01 TPK1 Androgen Signaling 1.29E00 6.94E-02 POLR2L,KAT2B,GTF2E1,GNB5,GTF2H2,HSP90AA1,GNG2,GNB1L,MNAT1,GNG7 Ephrin Receptor Signaling 1.29E00 6.97E-02 PAK6,ITSN1,GNB5,KRAS,RAP1A,GNG7,ATF2,GRINA,PTK2,RRAS2,MAP2K2,GNG2,GNB1L,RASA1 Melanocyte Development and Pigmentation Signaling 1.23E00 8.79E-02 PIK3CA,RRAS2,MAP2K2,MC1R,RPS6KA3,KIT,KRAS,ATF2 CCR3 Signaling in Eosinophils 1.23E00 7.87E-02 PIK3CA,RRAS2,MAP2K2,PAK6,GNB5,KRAS,GNG2,GNB1L,MAPK12,GNG7 HGF Signaling 1.23E00 8.57E-02 PTK2,MET,PIK3CA,RRAS2,MAP2K2,KRAS,MAPK12,RAP1A,ATF2 ErbB Signaling 1.21E00 9.2E-02 MTOR,PIK3CA,RRAS2,MAP2K2,FOXO1,PAK6,KRAS,MAPK12 Paxillin Signaling 1.2E00 8.11E-02 PTK2,PIK3CA,RRAS2,PAK6,KRAS,MAPK12,PTPN12,ACTN3,GIT2 FXR/RXR Activation 1.18E00 7.92E-02 MLXIPL,SLC4A2,FOXO1,IL1RN,FOXA2,RARA,FBP1,MAPK12 α-Adrenergic Signaling 1.18E00 7.62E-02 RRAS2,MAP2K2,GNB5,KRAS,GNG2,GNB1L,SLC8A1,GNG7 Granzyme A Signaling 1.18E00 1.5E-01 HIST1H1C,PRF1,NME1 4-1BB Signaling in T Lymphocytes 1.17E00 1.11E-01 MAP2K2,IKBKAP,MAPK12,ATF2 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza 1.17E00 1.14E-01 CXCL10,CCR1,IFNG,IL1RN,IL17A PTEN Signaling 1.17E00 7.52E-02 PTK2,PIK3CA,GHR,RRAS2,MAP2K2,FOXO1,INPP5F,IGF1R,KRAS,MAGI3 Pathogenesis of Multiple Sclerosis 1.15E00 2.22E-01 CXCL10,CCR1 Prostanoid Biosynthesis 1.15E00 1.33E-01 PTGDS,TBXAS1 UDP-N-acetyl-D-galactosamine Biosynthesis II 1.15E00 8.33E-02 GNPDA2,UAP1 UVA-Induced MAPK Signaling 1.14E00 8.7E-02 MTOR,PIK3CA,RRAS2,RPS6KA3,KRAS,MAPK12,PLCL1,SMPD3 P2Y Purigenic Receptor Signaling Pathway 1.13E00 7.25E-02 PIK3CA,RRAS2,MAP2K2,GNB5,KRAS,GNG2,GNB1L,PLCL1,GNG7,ATF2 IL-8 Signaling 1.11E00 6.83E-02 PIK3CA,PLD3,GNB5,KRAS,MAPK12,GNG7,PTK2,MTOR,ARRB2,RRAS2,MAP2K2,CXCR2,GNG2,GNB1L Aldosterone Signaling in Epithelial Cells 1.1E00 7.14E-02 PIK3CA,NEDD4,MAP2K2,HSP90AB1,DNAJC27,HSPH1,HSPB11,DNAJC1,HSP90AA1,KRAS,DNAJA1,PLCL1 G Protein Signaling Mediated by Tubby 1.09E00 9.52E-02 GNB5,GNG2,GNB1L,GNG7 Triacylglycerol Biosynthesis 1.09E00 8.7E-02 GPAM,DGAT2,MBOAT2,DBT NGF Signaling 1.08E00 7.63E-02 PIK3CA,RRAS2,MAP2K2,RPS6KA3,KRAS,MAPK12,SMPD3,RAP1A,ATF2 Role of NFAT in Regulation of the Immune Response 1.07E00 6.57E-02 PIK3CA,RRAS2,MAP2K2,CSNK1G3,ZAP70,FCER1A,GNB5,IKBKAP,KRAS,GNG2,GNB1L,GNG7,ATF2 Huntington's Disease Signaling 1.07E00 6.67E-02 PIK3CA,GNB5,Ubb,GNG7,ATF2,UBD,POLR2L,CASP6,DYNC1I2,MTOR,CAPNS1,HDAC7,IGF1R,GNG2,GNB1L,RASA1 NAD Phosphorylation and Dephosphorylation 1.07E00 1.18E-01 ACP5,NNT Glycine Betaine Degradation 1.07E00 8.7E-02 SDS,SDSL Tec Kinase Signaling 1.05E00 6.63E-02 STAT4,PTK2,PIK3CA,TXK,PAK6,GTF2I,GNB5,FCER1A,GNG2,GNB1L,MAPK12,GNG7 Protein Kinase A Signaling 1.05E00 6.3E-02 HIST1H1C,PTPN2,GNB5,TCF7L1,PDE4D,RAP1A,PTPN12,GNG7,ATF2,AKAP11,PTK2,PTPRC,AKAP2/PALM2-AKAP2,CAMK2D,MAP2K2,CDC26,DUSP10,CREM,TGFB2,DUSP11,GNG2,CTNNB1,PLCL1,GNB1L,PTPN21 fMLP Signaling in Neutrophils 1.04E00 6.98E-02 NCF1,PIK3CA,RRAS2,MAP2K2,GNB5,KRAS,GNG2,GNB1L,GNG7 GM-CSF Signaling 1.03E00 8.82E-02 PIK3CA,RRAS2,CAMK2D,MAP2K2,KRAS,BCL2A1 Maturity Onset Diabetes of Young (MODY) Signaling 1.02E00 9.68E-02 FABP2,FOXA2,CACNA1A Pyrimidine Ribonucleotides Interconversion 1.02E00 8.82E-02 NME1,NME7,NME6 Gαs Signaling 1.02E00 7.44E-02 MAP2K2,MC1R,GNB5,GNG2,GNB1L,RAP1A,PTGER4,GNG7,ATF2 Diphthamide Biosynthesis 1.01E00 7.69E-02 DPH5 Glutamine Biosynthesis I 1.01E00 1.25E-01 CCDC92 Taurine Biosynthesis 1.01E00 1.11E-01 CDO1 GDP-L-fucose Biosynthesis II (from L-fucose) 1.01E00 1.11E-01 FPGT Threonine Degradation II 1.01E00 1.11E-01 GCAT Glucocorticoid Receptor Signaling 9.8E-01 6.12E-02 IFNG,PIK3CA,GTF2F2,GTF2H2,KRAS,MAPK12,MNAT1,SMARCA4,POLR2L,KAT2B,RRAS2,MAP2K2,TAF5,HSP90AB1,IL1RN,GTF2E1,TGFB2,HSP90AA1 T Cell Receptor Signaling 9.51E-01 7.34E-02 PTPRC,PIK3CA,TXK,RRAS2,MAP2K2,ZAP70,KRAS,RASA1 Leukocyte Extravasation Signaling 9.42E-01 6.83E-02 CD99,PIK3CA,MMP14,RDX,MAPK12,RAP1A,PTK2,ARHGAP5,NCF1,TXK,MAP2K2,ARHGAP12,CTNNB1,ACTN3 Role of JAK1, JAK2 and TYK2 in Interferon Signaling 9.37E-01 1.11E-01 IFNG,PTPN2,CGA Pyrimidine Ribonucleotides De Novo Biosynthesis 9.37E-01 6.25E-02 NME1,NME7,NME6 Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism 9.37E-01 9.09E-02 IMPA1,INPP5F,ITPKA Endometrial Cancer Signaling 9.32E-01 8.77E-02 PIK3CA,RRAS2,MAP2K2,KRAS,CTNNB1 Purine Nucleotides De Novo Biosynthesis II 9.27E-01 4.76E-02 ADSS,PAICS GDNF Family Ligand-Receptor Interactions 9.08E-01 8.22E-02 PIK3CA,RRAS2,MAP2K2,KRAS,MAPK12,RASA1 Cardiac β-adrenergic Signaling 9.04E-01 6.45E-02 AKAP2/PALM2-AKAP2,GNB5,GNG2,GNB1L,SLC8A1,PDE4D,ATP2A2,GNG7,CACNA1A,AKAP11 IL-17A Signaling in Gastric Cells 8.97E-01 1.2E-01 CXCL10,MAPK12,IL17A NF-κB Signaling 8.93E-01 6.9E-02 TANK,AZI2,PIK3CA,GHR,RRAS2,MYD88,IL1RN,CARD10,TAB2,ZAP70,IGF1R,KRAS Docosahexaenoic Acid (DHA) Signaling 8.9E-01 8.16E-02 ALOX15,PIK3CA,FOXO1,BCL2A1 Chemokine Signaling 8.86E-01 8.22E-02 PTK2,RRAS2,CAMK2D,MAP2K2,KRAS,MAPK12 14-3-3-mediated Signaling 8.82E-01 7.44E-02 SRPK2,PIK3CA,RRAS2,MAP2K2,FOXO1,KRAS,MAPK12,PLCL1,TUBB2B Role of IL-17A in Arthritis 8.81E-01 7.94E-02 PIK3CA,MAP2K2,MAPK12,IL17A,ATF2 TR/RXR Activation 8.78E-01 7.29E-02 SLC16A3,MTOR,PIK3CA,UCP2,GPS2,STRBP,BCL3 Cholecystokinin/Gastrin-mediated Signaling 8.78E-01 7.55E-02 PTK2,RRAS2,MAP2K2,IL1RN,CREM,KRAS,MAPK12,ATF2 Role of IL-17A in Psoriasis 8.69E-01 1.54E-01 S100A9,IL17A CXCR4 Signaling 8.68E-01 6.55E-02 PTK2,PIK3CA,RRAS2,MAP2K2,PAK6,GNB5,KRAS,GNG2,GNB1L,MAPK12,GNG7 Acute Phase Response Signaling 8.66E-01 6.7E-02 MTOR,PIK3CA,ITIH3,RRAS2,MAP2K2,MYD88,IL1RN,KRAS,SOCS4,MAPK12,HNRNPK,SERPIND1 Mechanisms of Viral Exit from Host Cells 8.61E-01 8.89E-02 NEDD4,VPS28,VPS36,LMNB2 HIF1α Signaling 8.61E-01 7.48E-02 PIK3CA,EGLN1,RRAS2,MMP14,HSP90AA1,KRAS,MAPK12,NAA10 Colorectal Cancer Metastasis Signaling 8.51E-01 6.2E-02 IFNG,PIK3CA,MMP14,GNB5,KRAS,TCF7L1,MAPK12,GNG7,RRAS2,MAP2K2,MSH2,TGFB2,GNG2,GNB1L,CTNNB1,PTGER4 Cardiac Hypertrophy Signaling 8.47E-01 6.15E-02 PIK3CA,GNB5,KRAS,MAPK12,GNG7,CACNA1A,ATF2,MTOR,RRAS2,MAP2K2,TGFB2,IGF1R,GNG2,PLCL1,GNB1L L-carnitine Biosynthesis 8.46E-01 7.69E-02 ALDH9A1 Inosine-5'-phosphate Biosynthesis II 8.46E-01 6.25E-02 PAICS Thyroid Hormone Biosynthesis 8.46E-01 1.43E-01 TPO Glycerol-3-phosphate Shuttle 8.46E-01 1.11E-01 GPD1 N-acetylglucosamine Degradation I 8.46E-01 1.25E-01 GNPDA2 Rac Signaling 8.44E-01 6.56E-02 PTK2,PIK3CA,RRAS2,MAP2K2,PAK6,KRAS,IQGAP3,ANK1 Gαi Signaling 8.34E-01 6.82E-02 RRAS2,CXCR2,GNB5,RGS14,KRAS,GNG2,GNB1L,RAP1A,GNG7 Regulation of Cellular Mechanics by Calpain Protease 8.33E-01 6.94E-02 PTK2,RRAS2,CAPNS1,KRAS,ACTN3 FcγRIIB Signaling in B Lymphocytes 8.32E-01 6.78E-02 PIK3CA,RRAS2,KRAS,MAPK12 Cell Cycle Control of Chromosomal Replication 8.23E-01 9.68E-02 CDC45,ORC4,DBF4 Neuregulin Signaling 8.22E-01 6.86E-02 ERBB2IP,MTOR,RRAS2,MAP2K2,HSP90AB1,HSP90AA1,KRAS PAK Signaling 8.22E-01 6.6E-02 PTK2,PIK3CA,RRAS2,MAP2K2,PAK6,KRAS,MAPK12 Apoptosis Signaling 8.22E-01 7.37E-02 CASP6,RRAS2,CAPNS1,MAP2K2,KRAS,BCL2A1,BIRC3 Thrombin Signaling 8.17E-01 6.31E-02 PIK3CA,GNB5,KRAS,MAPK12,GATA2,GNG7,PTK2,RRAS2,CAMK2D,MAP2K2,GNG2,PLCL1,GNB1L DNA Double-Strand Break Repair by Non-Homologous End Joining 8.16E-01 1.05E-01 PRKDC,XRCC4 Leukotriene Biosynthesis 8.16E-01 8E-02 DPEP1,ALOX5 Phenylalanine Degradation IV (Mammalian, via Side Chain) 8.16E-01 5.13E-02 SLC27A2,ACSF3 CREB Signaling in Neurons 8.15E-01 5.91E-02 POLR2L,PIK3CA,RRAS2,CAMK2D,MAP2K2,GNB5,KRAS,GNG2,GNB1L,PLCL1,GNG7,ATF2 Germ Cell-Sertoli Cell Junction Signaling 8.14E-01 6.71E-02 PTK2,PIK3CA,RRAS2,MAP2K2,PAK6,TGFB2,KRAS,MAPK12,CTNNB1,ACTN3,TUBB2B Glioma Invasiveness Signaling 8.1E-01 8.33E-02 PTK2,PIK3CA,RRAS2,HMMR,KRAS ErbB2-ErbB3 Signaling 8.1E-01 8.33E-02 PIK3CA,RRAS2,MAP2K2,FOXO1,KRAS Melanoma Signaling 8.05E-01 8.7E-02 PIK3CA,RRAS2,MAP2K2,KRAS LPS-stimulated MAPK Signaling 8.03E-01 7.32E-02 PIK3CA,RRAS2,MAP2K2,KRAS,MAPK12,ATF2 RAR Activation 8.02E-01 6.35E-02 KAT2B,PIK3CA,RDH14,CYP26A1,RARA,TGFB2,GTF2H2,SORBS3,NR2F6,MAPK12,MNAT1,SMARCA4 PPARα/RXRα Activation 7.9E-01 6.28E-02 CAND1,GHR,MED23,GPD1,RRAS2,MAP2K2,HSP90AB1,LPL,TGFB2,HSP90AA1,KRAS,PLCL1 Myc Mediated Apoptosis Signaling 7.88E-01 8.33E-02 PIK3CA,RRAS2,IGF1R,KRAS,MAPK12 IL-1 Signaling 7.7E-01 6.54E-02 MYD88,TAB2,GNB5,GNG2,GNB1L,MAPK12,GNG7 VEGF Signaling 7.7E-01 6.8E-02 PTK2,PIK3CA,RRAS2,MAP2K2,FOXO1,KRAS,ACTN3 Isoleucine Degradation I 7.67E-01 6.67E-02 SDS,HADHA CDP-diacylglycerol Biosynthesis I 7.67E-01 7.41E-02 GPAM,MBOAT2 Renin-Angiotensin Signaling 7.63E-01 6.4E-02 PTK2,PIK3CA,RRAS2,MAP2K2,PAK6,KRAS,MAPK12,ATF2 Role of IL-17F in Allergic Inflammatory Airway Diseases 7.54E-01 8.51E-02 CXCL10,MAP2K2,RPS6KA3,ATF2 Natural Killer Cell Signaling 7.48E-01 6.9E-02 PIK3CA,SH2D1A,RRAS2,MAP2K2,PAK6,INPP5F,ZAP70,KRAS Molecular Mechanisms of Cancer 7.46E-01 5.56E-02 PRKDC,PIK3CA,PAK6,HAT1,TAB2,KRAS,AURKA,MAPK12,RAP1A,PTK2,CASP6,RRAS2,CAMK2D,FOXO1,MAP2K2,TGFB2,RBPJ,CTNNB1,BIRC3,ATR,RASA1 p53 Signaling 7.37E-01 7.29E-02 PRKDC,CASP6,KAT2B,PIK3CA,PLAGL1,CTNNB1,ATR Serine Biosynthesis 7.32E-01 7.69E-02 UBAC2 Branched-chain α-keto acid Dehydrogenase Complex 7.32E-01 1.11E-01 DBT Methylmalonyl Pathway 7.32E-01 8.33E-02 MUT Myo-inositol Biosynthesis 7.32E-01 1.25E-01 IMPA1 NAD Biosynthesis III 7.32E-01 1E-01 NAMPT L-cysteine Degradation I 7.32E-01 9.09E-02 CDO1 N-acetylglucosamine Degradation II 7.32E-01 8.33E-02 GNPDA2 Molybdenum Cofactor Biosynthesis 7.32E-01 6.67E-02 GPHN Tyrosine Biosynthesis IV 7.32E-01 1.25E-01 PCBD1 PDGF Signaling 7.29E-01 7.06E-02 PIK3CA,RRAS2,MAP2K2,INPP5F,KRAS,RASA1 Fatty Acid β-oxidation I 7.27E-01 6.67E-02 SLC27A2,SDS,HADHA Parkinson's Signaling 7.23E-01 1.25E-01 SNCAIP,MAPK12 Chronic Myeloid Leukemia Signaling 7.21E-01 6.67E-02 PIK3CA,RRAS2,MAP2K2,HDAC7,TGFB2,KRAS,CBLC PPAR Signaling 7.21E-01 6.67E-02 RRAS2,MAP2K2,HSP90AB1,PPARD,IL1RN,HSP90AA1,KRAS Nitric Oxide Signaling in the Cardiovascular System 7.11E-01 6.06E-02 PIK3CA,HSP90AB1,HSP90AA1,ATP2A2,GUCY1B3,CACNA1A Graft-versus-Host Disease Signaling 7.07E-01 8E-02 IFNG,PRF1,HLA-A,IL1RN Glioma Signaling 7.05E-01 6.25E-02 MTOR,PIK3CA,RRAS2,CAMK2D,MAP2K2,IGF1R,KRAS Mouse Embryonic Stem Cell Pluripotency 7.05E-01 7.07E-02 PIK3CA,RRAS2,MAP2K2,KRAS,TCF7L1,MAPK12,CTNNB1 Estrogen-Dependent Breast Cancer Signaling 7.05E-01 6.94E-02 PIK3CA,RRAS2,IGF1R,KRAS,ATF2 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 7.03E-01 5.88E-02 ACP5,IFNG,PIK3CA,MMP14,TAB2,TCF7L1,MAPK12,IL7,IL17A,COL1A1,FOXO1,IL1RN,CTNNB1,BIRC3 Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 6.94E-01 6.74E-02 RRAS2,MAP2K2,ZAP70,TGFB2,KRAS,MAPK12 CD40 Signaling 6.86E-01 7.14E-02 TANK,PIK3CA,MAP2K2,IKBKAP,MAPK12 ERK5 Signaling 6.86E-01 7.69E-02 RRAS2,RPS6KA3,KRAS,WNK1,ATF2 Autoimmune Thyroid Disease Signaling 6.84E-01 6.56E-02 PRF1,HLA-A,TPO,CGA TNFR1 Signaling 6.84E-01 7.69E-02 TANK,CASP6,PAK6,BIRC3 GABA Receptor Signaling 6.84E-01 7.14E-02 UBD,Ubb,GPHN,ALDH9A1 RAN Signaling 6.83E-01 8.33E-02 KPNA3,RANBP2 Phosphatidylglycerol Biosynthesis II (Non-plastidic) 6.83E-01 6.06E-02 GPAM,MBOAT2 Ovarian Cancer Signaling 6.67E-01 6.34E-02 MTOR,PIK3CA,RRAS2,MAP2K2,MSH2,KRAS,TCF7L1,CGA,CTNNB1 Hypoxia Signaling in the Cardiovascular System 6.49E-01 7.58E-02 HSP90AB1,HSP90AA1,UBE2V2,UBE2J1,ATF2 Proline Biosynthesis II (from Arginine) 6.46E-01 5E-02 OAT Pentose Phosphate Pathway (Oxidative Branch) 6.46E-01 9.09E-02 PGD Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate 6.46E-01 1E-01 MTHFD2 Glycerol Degradation I 6.46E-01 8.33E-02 GPD1 2-oxobutanoate Degradation I 6.46E-01 5.88E-02 MUT Phenylalanine Degradation I (Aerobic) 6.46E-01 8.33E-02 PCBD1 D-myo-inositol (1,4,5)-trisphosphate Degradation 6.45E-01 8.7E-02 IMPA1,INPP5F Gα12/13 Signaling 6.37E-01 6.35E-02 PTK2,PIK3CA,RRAS2,MAP2K2,KRAS,MAPK12,CTNNB1,RASA1 Telomerase Signaling 6.32E-01 6.8E-02 PIK3CA,RRAS2,MAP2K2,HSP90AB1,HDAC7,HSP90AA1,KRAS Oncostatin M Signaling 6.19E-01 8.57E-02 RRAS2,MAP2K2,KRAS Inhibition of Angiogenesis by TSP1 6.19E-01 7.69E-02 CD47,MAPK12,GUCY1B3 Interferon Signaling 6.19E-01 8.33E-02 IFNG,PTPN2,PIAS1 Remodeling of Epithelial Adherens Junctions 6.14E-01 7.46E-02 MET,NME1,CTNNB1,ACTN3,TUBB2B Neurotrophin/TRK Signaling 6.14E-01 6.67E-02 PIK3CA,RRAS2,MAP2K2,KRAS,ATF2 Synaptic Long Term Potentiation 6.12E-01 6.2E-02 RRAS2,CAMK2D,MAP2K2,KRAS,PLCL1,RAP1A,GRINA,ATF2 1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian) 6.11E-01 7.14E-02 INPP5F,ITPKA D-myo-inositol (1,3,4)-trisphosphate Biosynthesis 6.11E-01 8E-02 INPP5F,ITPKA DNA damage-induced 14-3-3σ Signaling 6.11E-01 9.52E-02 RAD17,ATR Agrin Interactions at Neuromuscular Junction 5.98E-01 7.25E-02 PTK2,RRAS2,PAK6,KRAS,MAPK12 Aryl Hydrocarbon Receptor Signaling 5.85E-01 5.59E-02 ALDH1L2,HSP90AB1,RARA,NEDD8,TGFB2,HSP90AA1,ATR,ALDH9A1,SMARCA4 CCR5 Signaling in Macrophages 5.82E-01 5.26E-02 GNB5,GNG2,GNB1L,MAPK12,GNG7 Growth Hormone Signaling 5.82E-01 6.58E-02 PIK3CA,GHR,IGF1R,RPS6KA3,SOCS4 Arginine Biosynthesis IV 5.77E-01 4.17E-02 OAT Superpathway of Serine and Glycine Biosynthesis I 5.77E-01 5.56E-02 UBAC2 Chondroitin and Dermatan Biosynthesis 5.77E-01 7.69E-02 CSGALNACT2 Glycine Cleavage Complex 5.77E-01 6.67E-02 AMT UDP-N-acetyl-D-glucosamine Biosynthesis II 5.77E-01 5.88E-02 UAP1 Zymosterol Biosynthesis 5.77E-01 4.55E-02 CYP51A1 Phospholipase C Signaling 5.74E-01 5.38E-02 PLD3,GNB5,RPS6KA3,KRAS,RAP1A,GNG7,ATF2,RRAS2,MAP2K2,HDAC7,ZAP70,GNG2,MARCKS,GNB1L UVB-Induced MAPK Signaling 5.65E-01 7.27E-02 MTOR,PIK3CA,RPS6KA3,MAPK12 IL-2 Signaling 5.65E-01 6.9E-02 PIK3CA,RRAS2,MAP2K2,KRAS Integrin Signaling 5.59E-01 5.8E-02 PTK2,ARHGAP5,PIK3CA,RRAS2,CAPNS1,MAP2K2,PAK6,TSPAN2,KRAS,TSPAN4,RAP1A,ACTN3 G Beta Gamma Signaling 5.58E-01 5.13E-02 RRAS2,GNB5,KRAS,GNG2,GNB1L,GNG7 IL-3 Signaling 5.51E-01 6.76E-02 PIK3CA,RRAS2,MAP2K2,FOXO1,KRAS PEDF Signaling 5.51E-01 6.41E-02 PIK3CA,RRAS2,KRAS,MAPK12,TCF12 BMP signaling pathway 5.36E-01 6.25E-02 RRAS2,MAP2K2,KRAS,MAPK12,ATF2 Thrombopoietin Signaling 5.3E-01 6.35E-02 PIK3CA,RRAS2,MAP2K2,KRAS Role of CHK Proteins in Cell Cycle Checkpoint Control 5.3E-01 7.02E-02 RAD17,ATMIN,TLK1,ATR Type I Diabetes Mellitus Signaling 5.3E-01 5.83E-02 IFNG,PRF1,HLA-A,MYD88,PIAS1,SOCS4,MAPK12 Notch Signaling 5.3E-01 6.98E-02 FURIN,RBPJ,JAG1 Epithelial Adherens Junction Signaling 5.22E-01 6.12E-02 MET,RRAS2,TGFB2,KRAS,TCF7L1,CTNNB1,RAP1A,ACTN3,TUBB2B Prolactin Signaling 5.21E-01 6.25E-02 PIK3CA,RRAS2,MAP2K2,KRAS,SOCS4 Fc Epsilon RI Signaling 5.18E-01 5.98E-02 PIK3CA,RRAS2,MAP2K2,INPP5F,FCER1A,KRAS,MAPK12 Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency 5.18E-01 6.14E-02 PIK3CA,RIF1,RRAS2,MAP2K2,KRAS,TCF7L1,CTNNB1 EGF Signaling 5.13E-01 6.45E-02 MTOR,PIK3CA,MAPK12,RASA1 Glioblastoma Multiforme Signaling 5.12E-01 5.49E-02 MTOR,PIK3CA,RRAS2,MAP2K2,FOXO1,IGF1R,KRAS,PLCL1,CTNNB1 GNRH Signaling 5.09E-01 5.33E-02 PTK2,RRAS2,CAMK2D,MAP2K2,PAK6,KRAS,MAPK12,ATF2 IL-4 Signaling 5.07E-01 6.33E-02 MTOR,PIK3CA,RRAS2,INPP5F,KRAS Role of Tissue Factor in Cancer 5.07E-01 6.09E-02 MTOR,PIK3CA,ARRB2,RRAS2,RPS6KA3,KRAS,MAPK12 EIF2 Signaling 5.02E-01 5.5E-02 PIK3CA,RPL6,RPL4,RRAS2,MAP2K2,RPL32,RPL7L1,EIF3J,RPS15A,KRAS,EIF2AK3 Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F 4.94E-01 8.7E-02 IFNG,IL17A Mitochondrial Dysfunction 4.93E-01 4.84E-02 COX17,FURIN,UCP2,PRDX5,ATP5A1,NDUFA12,NDUFA3,MAPK12,NDUFA7 Role of PKR in Interferon Induction and Antiviral Response 4.91E-01 6.52E-02 IFNG,TAB2,ATF2 Transcriptional Regulatory Network in Embryonic Stem Cells 4.91E-01 7.5E-02 RIF1,TCF7L1,SKIL Systemic Lupus Erythematosus Signaling 4.89E-01 5.2E-02 PTPRC,MTOR,PRPF18,RNPC3,PIK3CA,RRAS2,IL1RN,HLA-A,CD72,PRPF4B,CREM,KRAS,SNRPD3 Histidine Degradation III 4.73E-01 5.56E-02 MTHFD2 Sphingomyelin Metabolism 4.73E-01 6.25E-02 SMPD3 Tumoricidal Function of Hepatic Natural Killer Cells 4.7E-01 8.33E-02 CASP6,PRF1 AMPK Signaling 4.69E-01 4.79E-02 KAT2B,MTOR,PIK3CA,PPM1B,CHRNB1,PPM1A,MAPK12,SMARCA4 ATM Signaling 4.67E-01 6.56E-02 SMC3,TLK1,MAPK12,ATF2 VDR/RXR Activation 4.55E-01 6.17E-02 CXCL10,IFNG,FOXO1,PPARD,TGFB2 ErbB4 Signaling 4.53E-01 5.97E-02 PIK3CA,RRAS2,MAP2K2,KRAS IL-12 Signaling and Production in Macrophages 4.5E-01 5.13E-02 STAT4,ALOX15,IFNG,PIK3CA,MAP2K2,MYD88,TGFB2,MAPK12 Triacylglycerol Degradation 4.47E-01 6.25E-02 LPL,NDST2 Breast Cancer Regulation by Stathmin1 4.45E-01 5.31E-02 PIK3CA,RRAS2,CAMK2D,MAP2K2,GNB5,KRAS,TRPC5,GNG2,GNB1L,GNG7,TUBB2B IL-6 Signaling 4.43E-01 5.65E-02 COL1A1,PIK3CA,RRAS2,MAP2K2,IL1RN,KRAS,MAPK12 Relaxin Signaling 4.41E-01 5E-02 PIK3CA,GNB5,GNG2,GNB1L,PDE4D,RAP1A,GNG7,GUCY1B3 Cell Cycle: G2/M DNA Damage Checkpoint Regulation 4.38E-01 6.25E-02 PRKDC,KAT2B,ATR RhoA Signaling 4.34E-01 5.83E-02 PTK2,ARHGAP5,KTN1,SEPT7,IGF1R,RDX,ARHGAP12 p38 MAPK Signaling 4.34E-01 5.98E-02 IL1RN,DUSP10,TAB2,RPS6KA3,TGFB2,MAPK12,ATF2 Calcium Transport I 4.32E-01 7.69E-02 ATP2A2 Folate Transformations I 4.32E-01 3.12E-02 MTHFD2 Gap Junction Signaling 4.3E-01 5.11E-02 PIK3CA,RRAS2,MAP2K2,CSNK1G3,KRAS,PLCL1,CTNNB1,GUCY1B3,TUBB2B Role of JAK1 and JAK3 in γc Cytokine Signaling 4.25E-01 5.97E-02 PIK3CA,RRAS2,KRAS,IL7 iNOS Signaling 4.22E-01 5.66E-02 IFNG,MYD88,MAPK12 Sertoli Cell-Sertoli Cell Junction Signaling 4.15E-01 5.13E-02 RRAS2,MAP2K2,KRAS,MAPK12,CTNNB1,GUCY1B3,ACTN3,TUBB2B,OCLN,ATF2 Activation of IRF by Cytosolic Pattern Recognition Receptors 4.12E-01 5.56E-02 TANK,IKBKAP,MAPK12,ATF2 IL-17A Signaling in Airway Cells 4.12E-01 5.56E-02 PIK3CA,MAP2K2,MAPK12,IL17A Pyridoxal 5'-phosphate Salvage Pathway 4.12E-01 5.48E-02 CDK18,MAP2K2,PRPF4B,GRK6 IL-15 Production 4.05E-01 6.45E-02 PTK2,TXK TGF-β Signaling 3.97E-01 5.62E-02 RRAS2,MAP2K2,TGFB2,KRAS,MAPK12 Ketolysis 3.97E-01 5.26E-02 HADHA cAMP-mediated signaling 3.89E-01 5.36E-02 AKAP2/PALM2-AKAP2,CAMK2D,MAP2K2,MC1R,CXCR2,CREM,RGS14,PDE4D,RAP1A,PTGER4,AKAP11,ATF2 Non-Small Cell Lung Cancer Signaling 3.87E-01 5.06E-02 PIK3CA,RRAS2,MAP2K2,KRAS Role of PI3K/AKT Signaling in the Pathogenesis of Influenza 3.87E-01 5.41E-02 KPNA3,IFNG,PIK3CA,MAP2K2 TNFR2 Signaling 3.85E-01 6.06E-02 TANK,BIRC3 Intrinsic Prothrombin Activation Pathway 3.85E-01 5.71E-02 COL1A1,SERPINC1 Superpathway of Cholesterol Biosynthesis 3.67E-01 2.33E-02 HADHA,CYP51A1 Sonic Hedgehog Signaling 3.67E-01 6.06E-02 DYRK1B,ARRB2 Ketogenesis 3.65E-01 4.76E-02 HADHA Pentose Phosphate Pathway 3.65E-01 4.35E-02 PGD Erythropoietin Signaling 3.64E-01 5.13E-02 PIK3CA,RRAS2,MAP2K2,KRAS Mitotic Roles of Polo-Like Kinase 3.64E-01 5.71E-02 SMC3,HSP90AB1,CDC26,HSP90AA1 RANK Signaling in Osteoclasts 3.56E-01 5.26E-02 PIK3CA,MAP2K2,TAB2,MAPK12,BIRC3 IL-10 Signaling 3.53E-01 5.13E-02 CCR1,IL1RN,ARG2,MAPK12 Macropinocytosis Signaling 3.53E-01 5.26E-02 MET,PIK3CA,RRAS2,KRAS Superpathway of Methionine Degradation 3.5E-01 3.12E-02 CDO1,MUT iCOS-iCOSL Signaling in T Helper Cells 3.5E-01 4.88E-02 PTPRC,PIK3CA,CAMK2D,ZAP70,PLEKHA4,ICOSLG Pancreatic Adenocarcinoma Signaling 3.5E-01 5E-02 PIK3CA,PLD3,MAP2K2,TGFB2,KRAS,MAPK12 T Helper Cell Differentiation 3.42E-01 5.56E-02 STAT4,IFNG,ICOSLG,IL17A Hematopoiesis from Multipotent Stem Cells 3.38E-01 8.33E-02 IL7 Glutaryl-CoA Degradation 3.38E-01 4.17E-02 HADHA Oleate Biosynthesis II (Animals) 3.38E-01 5.56E-02 UFSP2 Virus Entry via Endocytic Pathways 3.37E-01 5.05E-02 PIK3CA,RRAS2,ITSN1,HLA-A,KRAS Regulation of eIF4 and p70S6K Signaling 3.35E-01 4.57E-02 MTOR,PIK3CA,RRAS2,MAP2K2,EIF3J,RPS15A,KRAS,MAPK12 CD27 Signaling in Lymphocytes 3.26E-01 5.26E-02 MAP2K2,IKBKAP,MAPK12 Amyloid Processing 3.26E-01 5.36E-02 CAPNS1,MARK1,MAPK12 B Cell Development 3.19E-01 6.06E-02 PTPRC,IL7 Semaphorin Signaling in Neurons 3.14E-01 5.77E-02 PTK2,MET,PAK6 mTOR Signaling 3.13E-01 4.74E-02 MTOR,RHEB,PIK3CA,PLD3,RRAS2,RPS6KA3,EIF3J,RPS15A,KRAS,GNB1L Fatty Acid Activation 3.13E-01 5.26E-02 SLC27A2 Choline Biosynthesis III 3.13E-01 4.55E-02 PLD3 Cholesterol Biosynthesis I 3.13E-01 2.5E-02 CYP51A1 Bile Acid Biosynthesis, Neutral Pathway 3.13E-01 1.72E-02 SCP2 Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol) 3.13E-01 2.5E-02 CYP51A1 Histamine Degradation 3.13E-01 3.45E-02 ALDH9A1 Cholesterol Biosynthesis III (via Desmosterol) 3.13E-01 2.5E-02 CYP51A1 Insulin Receptor Signaling 3.08E-01 4.93E-02 MTOR,PIK3CA,RRAS2,MAP2K2,FOXO1,INPP5F,KRAS Circadian Rhythm Signaling 3.04E-01 5.41E-02 GRINA,ATF2 TWEAK Signaling 3.04E-01 5.26E-02 CASP6,BIRC3 Ethanol Degradation II 3.04E-01 4.65E-02 RDH14,ALDH9A1 NF-κB Activation by Viruses 3.02E-01 4.88E-02 PIK3CA,RRAS2,KRAS,IKBKAP Leptin Signaling in Obesity 2.93E-01 4.82E-02 PIK3CA,MAP2K2,FOXO1,PLCL1 Mevalonate Pathway I 2.9E-01 3.57E-02 HADHA Fatty Acid α-oxidation 2.9E-01 4.76E-02 ALDH9A1 IL-9 Signaling 2.9E-01 5E-02 PIK3CA,BCL3 Role of JAK2 in Hormone-like Cytokine Signaling 2.9E-01 5.56E-02 GHR,SOCS4 G-Protein Coupled Receptor Signaling 2.86E-01 4.76E-02 PIK3CA,CAMK2D,RRAS2,MC1R,MAP2K2,CXCR2,RGS14,KRAS,PDE4D,RASA1,RAP1A,PTGER4,ATF2 Dendritic Cell Maturation 2.83E-01 4.35E-02 STAT4,COL1A1,PIK3CA,HLA-A,MYD88,IL1RN,MAPK12,PLCL1,ATF2 Role of Cytokines in Mediating Communication between Immune Cells 2.81E-01 5.45E-02 IFNG,IL1RN,IL17A Type II Diabetes Mellitus Signaling 2.8E-01 3.73E-02 MTOR,PIK3CA,SLC27A2,SOCS4,MAPK12,SMPD3 Coagulation System 2.77E-01 5.26E-02 SERPINC1,SERPIND1 IL-17A Signaling in Fibroblasts 2.77E-01 5E-02 MAPK12,IL17A Stearate Biosynthesis I (Animals) 2.77E-01 4.08E-02 SLC27A2,DBT Noradrenaline and Adrenaline Degradation 2.77E-01 3.85E-02 RDH14,ALDH9A1 HER-2 Signaling in Breast Cancer 2.75E-01 5E-02 PIK3CA,RRAS2,FOXO1,KRAS VEGF Family Ligand-Receptor Interactions 2.75E-01 4.76E-02 PIK3CA,RRAS2,MAP2K2,KRAS Phospholipases 2.71E-01 4.55E-02 CCR1,PLD3,PLCL1 Toll-like Receptor Signaling 2.71E-01 4.84E-02 MYD88,TAB2,MAPK12 nNOS Signaling in Skeletal Muscle Cells 2.7E-01 3.23E-02 SNTA1 Calcium Signaling 2.67E-01 4.25E-02 CAMK2D,HDAC7,CHRNB1,TRPC5,SLC8A1,ATP2A2,RAP1A,GRINA,ATF2 Amyotrophic Lateral Sclerosis Signaling 2.63E-01 4.27E-02 PIK3CA,CAPNS1,BIRC3,CACNA1A,GRINA Glutamate Receptor Signaling 2.62E-01 4.35E-02 GNG2,GNG7,GRINA Regulation of the Epithelial-Mesenchymal Transition Pathway 2.61E-01 4.71E-02 MET,PIK3CA,RRAS2,MAP2K2,TGFB2,RBPJ,KRAS,TCF7L1,JAG1 p70S6K Signaling 2.59E-01 4.65E-02 MTOR,PIK3CA,RRAS2,MAP2K2,KRAS,PLCL1 Dopamine-DARPP32 Feedback in cAMP Signaling 2.59E-01 4.37E-02 CSNK1G3,CREM,PLCL1,ATP2A2,GUCY1B3,CACNA1A,GRINA,ATF2 Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza 2.58E-01 4.94E-02 IFNG,CSNK1G3,TCF7L1,CTNNB1 Antigen Presentation Pathway 2.53E-01 5E-02 IFNG,HLA-A Atherosclerosis Signaling 2.53E-01 4.41E-02 COL1A1,ALOX15,IFNG,IL1RN,LPL,ALOX5 Death Receptor Signaling 2.52E-01 4.69E-02 TANK,CASP6,BIRC3 Extrinsic Prothrombin Activation Pathway 2.52E-01 5E-02 SERPINC1 Mismatch Repair in Eukaryotes 2.52E-01 4.17E-02 MSH2 Oxidative Ethanol Degradation III 2.52E-01 2.5E-02 ALDH9A1 Induction of Apoptosis by HIV1 2.43E-01 4.62E-02 IKBKAP,MAPK12,BIRC3 Ceramide Signaling 2.43E-01 4.49E-02 PIK3CA,RRAS2,KRAS,SMPD3 tRNA Charging 2.42E-01 2.47E-02 VARS,IARS γ-linolenate Biosynthesis II (Animals) 2.35E-01 4.17E-02 SLC27A2 Mitochondrial L-carnitine Shuttle Pathway 2.35E-01 4.55E-02 SLC27A2 Putrescine Degradation III 2.35E-01 3.33E-02 ALDH9A1 B Cell Activating Factor Signaling 2.21E-01 4.44E-02 IKBKAP,MAPK12 Neuroprotective Role of THOP1 in Alzheimer's Disease 2.21E-01 3.7E-02 IFNG,HLA-A Cardiomyocyte Differentiation via BMP Receptors 2.2E-01 5E-02 ATF2 Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F 2.2E-01 5.56E-02 IL17A Tryptophan Degradation X (Mammalian, via Tryptamine) 2.2E-01 3.45E-02 ALDH9A1 Ethanol Degradation IV 2.2E-01 3.45E-02 ALDH9A1 Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate) 2.2E-01 2.78E-02 HADHA Endoplasmic Reticulum Stress Pathway 2.2E-01 5.56E-02 EIF2AK3 GADD45 Signaling 2.06E-01 4.55E-02 ATR DNA Methylation and Transcriptional Repression Signaling 1.93E-01 4.35E-02 RBBP7