Important Links Online Registration N www.IMMUNOLOGY2009.org/registration.htm Hotel Reservations N www.IMMUNOLOGY2009.org/housing.htm International Attendees N www.IMMUNOLOGY2009.org/VisaInformation.htm
For program updates and complete meeting information, visit www.IMMUNOLOGY2009.org IMMUNOLOGY 2009™ PROGRAM 3EE YOU IN 3EATTLE
AAI PRESIDENTIAL PROGRAM AAI Presidential Address Presentation of the AAI Excellence TCR Signal Transduction: in Mentoring Award Opening the Black Box MONDAY, MAY 11 N 2:30 PM Chair: Arthur Weiss, HHMI, University of California, FRIDAY, MAY 8, 2009 N 5:00 PM Arthur Weiss, HHMI, University of California, San Francisco, AAI President San Francisco, AAI President Award Recipient: David Baltimore, California Institute Introduction: Gary A. Koretzky, University of Pennsylvania of Technology School of Medicine Introduction: Frederick W. Alt, HHMI, Children’s Hospital Boston, CBR Institute, Harvard Medical School Presentation of the AAI Lifetime The AAI Excellence in Mentoring Award recognizes an AAI member’s Achievement Award exemplary career contributions to a future generation of scientists. The award FRIDAY, MAY 8 N 5:00 PM will be presented prior to the start of the AAI Presidential Symposium. Chair: Arthur Weiss, HHMI, University of California, San Francisco, AAI President Award Recipient: Steven J. Burakoff, The Tisch Cancer AAI DISTINGUISHED LECTURES Institute, Mount Sinai Medical Center Generously supported by eBioscience, Inc. The AAI Lifetime Achievement Award is the highest honor bestowed by the AAI Council upon an AAI member. This award recognizes a deserving member for a career of scientific achievement and for contributions to AAI and fellow immunologists. The award will be presented prior to the start of the AAI Presidential Address. AAI Presidential Symposium Signaling by Antigen Receptors: From Molecules SATURDAY, MAY 9 SUNDAY, MAY 10 MONDAY, MAY 11 to Models 5:00 PM 5:00 PM 5:00 PM Megan Sykes John C. Cambier Alexander Y. MONDAY, MAY 11, 2009 N 2:30 PM Massachusetts General University of Colorado Rudensky Chair: Arthur Weiss, HHMI, University of California, San Francisco, Hospital and Harvard Denver School of HHMI, Memorial AAI President Medical School Medicine and National Sloan-Kettering Controlling the Jewish Health Cancer Center alloresponse: Anergy vs. activation: Foxp3: a key to between benches, the B cell antigen receptor dominant tolerance to the bedside as a molecular switch and back
Lawrence E. Gary A. Doreen A. Arup K. Samelson Koretzky Cantrell Chakraborty NCI, NIH University of University of Massachusetts Signaling at Pennsylvania Dundee Institute of the T cell School of Medicine Matching Technology antigen receptor Regulation of lymphocyte Molecular origin immune cell metabolism and and functional development and migration consequences of function by adapter digital signaling in proteins lymphocytes 96th Annual Meeting The American Association of Immunologists -AY n s 3EATTLE 7ASHINGTON 7ASHINGTON 3TATE #ONVENTION 4RADE #ENTER
AAI MAJOR SYMPOSIA
SATURDAY, MAY 9, 2009 N 8–11:30 AM Major Symposium D: MicroRNAs Chair: Judy Lieberman, Immune Disease Institute and Harvard Medical School Major Symposium A: Triggers of Autoimmunity Co-Chair: K. Mark Ansel, University of California, San Francisco Chair: Joanne L. Viney, Amgen Corporation Co-Chair: Dale T. Umetsu, Children’s Hospital Boston and K. Mark Ansel, University of California, San Francisco, MicroRNA Harvard Medical School homeostasis in lymphocytes Joshua Mendell, Johns Hopkins University School of Medicine, MicroRNA Joanne L. Viney, Amgen Corporation, Triggers of intestinal inflammation reprogramming by oncogenes and tumor suppressors Dale T. Umetsu, Children’s Hospital Boston and Harvard Medical School, Judy Lieberman, Immune Disease Institute and Harvard Medical School, IL-17-producing natural killer T cells in the lungs Silencing cell proliferation Joan M. Goverman, University of Washington, Th17 and Th1 cells in Chang-Zheng Chen, Stanford University School of Medicine, CNS autoimmunity Micromanaging immune systems by the miR-181 family genes Nicholas P. Restifo, NCI, NIH, Triggering autoimmunity with cancer Jeffrey A. Bluestone, University of California, San Francisco, Role therapeutics of microRNAs in autoimmunity: a key role in regulatory and memory Alexander V. Chervonsky, University of Chicago, Commensal bacteria T cell function and type 1 diabetes David Baltimore, California Institute of Technology, MicroRNAs and Sarkis K. Mazmanian, California Institute of Technology, Dysbiosis immunity as a trigger for autoimmune colitis and systemic inflammation Major Symposium B: The Inflammasome MONDAY, MAY 11, 2009 N 8–11:30 AM Chair: Gabriel Núñez, University of Michigan Co-Chair: Jonathan A. Harton, Albany Medical College Major Symposium E: Epigenetic Regulation of the Gabriel Núñez, University of Michigan Cancer Center, Activation of the Immune Response inflammasome by bacterial pathogens Chair: Ann J. Feeney, The Scripps Research Institute Jenny P.Y. Ting, Lineberger Comprehensive Cancer Center, Genetic and Co-Chair: Stephen T. Smale, University of California, Los Angeles functional analysis of NLR genes Vishva M. Dixit, Genentech, Inc., The cryopyrin/NALP3 inflammasome Ann J. Feeney, The Scripps Research Institute, Epigenetic regulation Jonathan A. Harton, Albany Medical College, of immunoglobulin gene recombination Pyrin-only proteins: regulators of the inflammasome Cornelis Murre, University of California, San Diego, The 3-D structure Fayyaz S. Sutterwala, University of Iowa, Sterile inflammatory of the immunoglobulin heavy chain locus: implications for the generation responses mediated by the NLRP3 inflammasome of antibody diversity Eicke Latz, University of Massachusetts Medical School, Activation Michael S. Krangel, Duke University Medical Center, Epigenetic regulation of the NALP3 inflammasome by lysosomal damage of TCR gene assembly Amy S. Weinmann, University of Washington, The role for T-box proteins in establishing epigenetic states in immune cells SUNDAY, MAY 10, 2009 N 8–11:30 AM Stephen T. Smale, University of California, Los Angeles, Selective regulation of pro-inflammatory genes by chromatin Major Symposium C: Bridging Adaptive and Innate Immunity Christopher B. Wilson, University of Washington, Epigenetic regulation Generously supported by Kyowa Hakko Kirin California, Inc. of T helper cell differentiation and function Chair: Hilde Cheroutre, La Jolla Institute for Allergy and Immunology Major Symposium F: T Cell Response to Pathogens Co-Chair: Youhai H. Chen, University of Pennsylvania School of Medicine Chair: Michael J. Bevan, HHMI, University of Washington, Seattle Carla V. Rothlin, Salk Institute, TAMing inflammation: introducing a novel Co-Chair: Marcia A. Blackman, Trudeau Institute anti-inflammatory receptor tyrosine kinase signaling pathway John T. Harty, University of Iowa, CD8+ T cell immunity to microbes Youhai H. Chen, University of Pennsylvania School of Medicine, Toll-like Marcia A. Blackman, Trudeau Institute, The impact of aging on T cell receptor signaling: gene- and signal-specific regulators repertoire and immunity to influenza virus Eugene C. Butcher, Stanford University, Chemoattractant receptors at the Nilabh Shastri, University of California, Berkeley, Immune responses interface of innate and adaptive immunity to Toxoplasma Gondii Wendy L. Havran, The Scripps Research Institute, Crosstalk between gamma Francis R. Carbone, University of Melbourne, Dendritic cells and tissue- delta T cells and their epithelial neighbors resident T cells contribute to the memory response during localized infections Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, Mucosal David Masopust, University of Minnesota, Memory T cells: issues of quantity, immunity: it is all a matter of “gut” decisions quality and location Randolph J. Noelle, Dartmouth Medical School, Regulation of peripheral Cliona M. Rooney, Baylor College of Medicine, Improving multipathogen- tolerance in transplantation and cancer specific T cell therapies IMMUNOLOGY 2009™
TUESDAY, MAY 12, 2009 N 8–11:30 AM SPECIAL EVENTS Major Symposium G: IL-23/IL-17 Axis in T Cell Differentiation and Tissue Inflammation AAI Opening Reception Chair: Vijay K. Kuchroo, Harvard Medical School and Brigham and Generously sponsored by eBioscience, Inc. Women’s Hospital Friday, May 8 N 6:30 – 8:00 PM N WSCTC Exhibit Hall Co-Chair: Wenjun Ouyang, Genentech, Inc. New this year! Immediately following the Presidential Steven D. Levin, ZymoGenetics, Inc., Ancillary molecules in the Address, attendees are invited to the exhibit floor to seek development and function of Th17 cells out friends and the many exciting new offers from the Vijay K. Kuchroo, Harvard Medical School and Brigham and Women’s AAI exhibitors. Hospital, Reciprocal relationship between Treg and Th17 cells Wenjun Ouyang, Genentech, Inc., The functions of IL-22 and IL-17 Young Investigators Party (YIP!) in autoimmune and infectious diseases Saturday, May 9 N 9:00 – 11:00 PM John J. O’Shea, NIAMS, NIH, Signal transduction in Th17 development Grand Hyatt Seattle Hotel N Leonesa Ballroom Sarah L. Gaffen, University of Pittsburgh, Structure-function relationships This always popular event has been scheduled for in the IL-17 receptor complex Saturday “prime time” this year and given a new format. Major Symposium H: Cell Fate Decisions in Young scientists will enjoy a relaxed but festive atmosphere Lymphocyte Development to meet, network—and dance! Chair: Ellen V. Rothenberg, California Institute of Technology AAI Gala Co-Chair: Jonathan G. Kaye, The Scripps Research Institute Generously sponsored by BioLegend Jonathan G. Kaye, The Scripps Research Institute, Multiple roles for nuclear Sunday, May 10 N 7:00 – 10:00 PM factor TOX in development of the immune system Paul E. Love, NICHD, NIH, A new T cell-specific protein with a critical role Benaroya Concert Hall, Seattle in thymocyte development For AAI members with invitations only Harald von Boehmer, Dana-Farber Cancer Institute and Harvard Medical Following a reception School, Notch1 and c-myc in alpha beta T-lineage fate and lymphoma in the spectacular Nancy A. Speck, University of Pennsylvania School of Medicine, Roles atrium lobby of the of core binding factors (Runx/CBFB) in hematopoietic lineage choice Benaroya Hall, Ellen V. Rothenberg, California Institute of Technology, A genomic view guests will enter of T-lineage specification and commitment Avinash Bhandoola, University of Pennsylvania School of Medicine, the concert hall for Notch signals constrain the myeloid potential of early thymic progenitors a program tailored uniquely for AAI!
BLOCK SYMPOSIA Submitted abstracts are programmed into oral or poster sessions; oral sessions are called Block Symposia. Each abstract selected for a Block Symposium will also be presented in a Poster Session. Approximately 50 Block Symposia will be presented at IMMUNOLOGY 2009™; all sessions will be held in the Washington State Convention & Trade Center. POSTER SESSIONS The most interactive part of the meeting! Discuss data and research issues firsthand with authors at the Poster Sessions. Posters will be displayed Saturday through Monday in the Washington State Convention & Trade Center Exhibit Hall from 8:00 AM – 5:00 PM, with authors present from 12:30 –1:30 PM. AAI Awards
The AAI Awards Program honors members across the career spectrum. AAI awards are presented throughout the meeting in special sessions. Awards Presentations and Lectures Attend the AAI Business AAI-Dana Foundation Award in Human Immunology Research Meeting & Awards Presentation! Presentation and Lecture Generously supported by the Dana Foundation MONDAY, MAY 11 N 12:45 PM Saturday, May 9 N 3:15 PM In addition to awards presentations, Chair: Arthur Weiss, HHMI, University of California, this session will include the annual San Francisco, AAI President report to AAI members on AAI and Award Recipient/Lecturer: The Journal of Immunology business Jacques Banchereau, Baylor Institute for Immunology affairs. Lunch will be provided Research, Human immunology: a fertile field for basic (no ticket required). and patient-oriented discoveries AAI-BD Biosciences Investigator Award Additional awards Presentation and Lecture to be given in conjunction Generously supported by BD Biosciences with IMMUNOLOGY 2009™: Sunday, May 10 N 2:30 PM Chair: Arthur Weiss, HHMI, University of California, AAI Junior Faculty Travel Grants San Francisco, AAI President Assist young investigators with travel Award Recipient/Lecturer: to the AAI Annual Meeting. Selection Chen Dong, The University of Texas MD Anderson based on career promise and submission Cancer Center, Many paths of peripheral T cells of a first-author abstract to the Annual Meeting. AAI-Invitrogen Meritorious Career Award Presentation and Lecture AAI Trainee Abstract Awards Generously supported by Invitrogen Corporation Awarded to AAI trainee members Sunday, May 10 N 3:30 PM (students and postdoctoral fellows) Chair: Arthur Weiss, HHMI, University of California, whose first-author abstracts are selected San Francisco, AAI President for oral presentation in an AAI Block Award Recipient/Lecturer: Symposium. Michael J. Bevan, HHMI, University of Washington, Seattle, Matching antigen strength in the thymus AAI Minority Scientist Travel Awards and periphery Support the participation of under- represented minority scientists at the AAI Awards Presentations Annual Meeting; funded by a grant from at the AAI Business Meeting the National Institute of General Medical Monday, May 11 N 12:45 PM Sciences, NIH [FASEB MARC Program: T36-GM08059-26]. AAI Distinguished Service Award Presentation Award Recipient: John G. Monroe, Genentech, Inc. AAI-Invitrogen Trainee Achievement Awards Cynthia Chambers Memorial– eBioscience Junior Faculty Award Pfizer-Showell Travel Award
For complete information on all AAI Awards, please visit www.aai.org/Awards. IMMUNOLOGY 2009™
AAI COMMITTEE-SPONSORED SESSIONS David A. Relman, Member, National Science Advisory Board on Biosecurity (NSABB); Professor of Microbiology & Immunology, and of Medicine, CLINICAL IMMUNOLOGY COMMITTEE Stanford University; Chief of Infectious Diseases, VA Palo Alto Health Care System, The future life sciences landscape: benefits and risks Scourge of the Mummies: TB Then and Now David R. Franz, Co-Chair, National Science Advisory Board on Biosecurity SATURDAY, MAY 9, 10:15 AM – 12:15 PM (NSABB) International Working Group; Chief Biological Scientist, Midwest Research Institute (Frederick, Maryland), Regulating “dual-use” Chair: Kathleen E. Sullivan, Children’s Hospital of Philadelphia, Chair, research: if the U.S. does, will the world follow? AAI Clinical Immunology Committee Paul S. Keim, Chair, National Science Advisory Board on Biosecurity Co-Chair: Cathryn Nagler, Massachusetts General Hospital and Harvard (NSABB) Communications Working Group; Director of Pathogen Genom- Medical School, Co-Chair, AAI Clinical Immunology Committee ics, The Translational Research Institute (TGen); Director, Center for Jerald C. Sadoff, Aeras Foundation, TB vaccine development in modern Microbial Genetics and Genomics, and The Cowden Endowed Chair in times Microbiology, Northern Arizona University, Flagstaff Arizona, The anthrax Joel D. Ernst, NYU School of Medicine, Dendritic cell traffic and antigen letter attacks: investigating the researchers, investigating the crime presentation in tuberculosis BIOTERRORISM! Caused by a rogue scientist or caused, unknowingly, by Shabaana A. Khader, Children’s Hospital of Pittsburgh, T cell-mediated you?! Caused by you because you didn’t know about “dual use research” (re- immunity to tuberculosis search that can be used for both beneficial and nefarious purposes). Samuel M. Behar, Brigham and Women’s Hospital and Harvard Medical This session will explore the political and scientific issues surrounding dual School, Lipid mediators modulate the cellular fate of infected macrophages use research, its dangers and benefits—including its forensic role in identify- and regulate innate and adaptive immunity to tuberculosis ing suspects in the 2002 anthrax case—and many of the key concerns about government regulation of such research. A question and answer period will COMMITTEE ON PUBLIC AFFAIRS follow the presentations. Immunology at CDC: Research Opportunities in Public Health EDUCATION COMMITTEE SATURDAY, MAY 9, 12:30 – 2:00 PM *Just Added! The NIH Grant Maze: Navigating Chair: William R. Green, Dartmouth Medical School, Chair, AAI Old Turns and New Twists Committee on Public Affairs SATURDAY, MAY 9, 10:15 AM – 12:15 PM Alison C. Mawle, Associate Director for Laboratory Science, National See CAREER DEVELOPMENT PROGRAMS section, below Center for Immunization and Respiratory Diseases, Coordinating Center John H. Wallace High School Teachers Workshop: for Infectious Diseases, Centers for Disease Control and Prevention, Lessons in Immunology Immunology at CDC: why it matters Conrad Quinn, Molecular Pathogenesis and Immunology Team, SATURDAY, MAY 9, 10:15 AM – 12:15 PM Meningitis and Vaccine Preventable Diseases Branch, Division Chair: Brian A. Cobb, Case Western Reserve University School of Medicine of Bacterial Diseases, National Center for Immunization and The AAI High School Teachers Program brings the excitement of immunology Respiratory Diseases, Coordinating Center for Infectious Diseases, directly to high school students by sending high school science teachers into Centers for Disease Control and Prevention, Anthrax vaccines— the laboratories of established immunologists who mentor them in a from Pasteur to pasture to PA “hands-on” summer internship. The teachers develop a science project f Ellen Kersh, Laboratory Branch, Pre-clinical Evaluation Team, Division or the classroom based on their summer experience. The teachers present of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD and their experiences and projects in this session. TB Prevention, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Immunological factors impact 2008–2009 PROGRAM PARTICIPANTS susceptibility to SHIV in a macaque model of repeated mucosal Teacher: Mary Haus, Los Osos High School, Rancho Cucamonga, CA viral challenge Mentor: Roberta R. Pollock, Department of Biology, Occidental College, This session will surprise you, as you learn about some of the exciting Los Angeles, California immunological research being conducted at the CDC. Speakers will also Teacher: Monica Thoune, Bay Middle College/Fitzharris High School, describe ongoing collaborative and interagency work, as well as funding Delta-Schoolcraft Intermediate School District, Wells, Michigan opportunities for scientists. A question and answer period will follow Mentor: Mariana J. Kaplan, University of Michigan Medical School, the presentations. Ann Arbor, Michigan Teacher: David Mwangi, East Orange High School, East Orange, New Jersey Good Science Gone Bad: “Dual Use” Research and Mentor: Patricia Fitzgerald-Bocarsly, UMDNJ—New Jersey Medical How it Affects You School, Newark, New Jersey SUNDAY, MAY 10, 12:30 – 2:30 PM Teacher: Kevin Jarigese, West Mesa High School, Albuquerque, New Mexico Mentor: Carolyn Mold, Department of Molecular Genetics and Chair: William R. Green, Dartmouth Medical School, Chair, AAI Microbiology, University of New Mexico, Albuquerque, New Mexico Committee on Public Affairs Teacher: Rita English, John F. Kennedy Memorial High School, Iselin, Keynote Speaker: Dennis L. Kasper, Chair, National Science Advisory New Jersey Board for Biosecurity (NSABB); William Ellery Channing Professor Mentor: Debra Laskin, Department of Pharmacology/Toxicology, of Medicine and Professor of Microbiology and Molecular Genetics, Rutgers University, Piscataway, New Jersey Harvard Medical School; Director, Channing Laboratory, and Senior Teacher: Nels Dokken, John F. Kennedy High School, South Bloomington, Physician, Brigham and Women’s Hospital, Good research for bad Minnesota purposes: how to know “dual use’”research when you see it, and when Mentor: Chris Pennell, Department of Laboratory Medicine you should worry & Pathology, University of Minnesota, Minneapolis, Minnesota EDUCATION COMMITTEE and COMMITTEE PUBLICATIONS COMMITTEE ON THE STATUS OF WOMEN Course: Excellence in Scientific Writing Careers in Science: Lecture and Roundtable Discussion FRIDAY, MAY 8, 12:00 – 4:00 PM SATURDAY, MAY 9, 1:30 – 3:30 PM Improve the quality of your publications and grant applications. This interac- Chair: Christine Milcarek, University of Pittsburgh, Chair, AAI Committee tive half-day workshop will, through examples and class participation, focus on the Status of Women on the essentials of effective writing and strategies for clear communication. Co-Chair: Bonnie N. Dittel, BloodCenter of Wisconsin, Blood Research Course is limited to 100 attendees. Institute Registration, $100 fee required Speaker: Phyllis M. Wise, Provost and Executive Vice President, University of Washington Scientific Publishing: Dos and Don’ts Learn about career options and successful paths to each in this afternoon for Authors and Reviewers session. Following Dr. Wise’s lecture, experienced scientists will serve as SUNDAY, MAY 10, 12:30 – 2:30 PM roundtable discussion leaders and offer one-on-one insight about specific Chair: Robert D. Schreiber, Washington University (St. Louis) School career issues and options important to men and women in science today. of Medicine, Chair, AAI Publications Committee Attendance will be limited to the first 300 registrants. Roundtable topics will address career options and issues that challenge success at all career stages. Pamela J. Fink, University of Washington School of Medicine, Dos and General don’ts when writing a scientific manuscript Topics related to the environment you work in or want to work in JoAnne L. Flynn, University of Pittsburgh School of Medicine, Essentials s !CADEMIC 2ESEARCH for becoming a valued reviewer s "IOTECH AND )NDUSTRY Pamela A. Shaw, NIAID, NIH, The appropriate use of statistics in the s 'OVERNMENTAL !GENCIES #$#&$!.)( biological sciences s #LINIC CLINICAL AND DIAGNOSTIC IMMUNOLOGY CLINICIAN SCIENTIST Jeremy M. Boss, Emory University School of Medicine, What do you s 5NDERGRADUATE )NSTITUTIONS TEACHING DOING RESEARCH PART TIME mean I already published it? Ethics in scientific publishing Transitions Topics focused on a specific career stage NIH INSTITUTE-SPONSORED SYMPOSIA s 'RADUATE 3TUDENT TO 0OST DOC lNDING A POST DOC INTERVIEWING s 0OST DOC TO 0) lNDING A POSITION INTERVIEWING NEGOTIATING LAB NATIONAL CANCER INSTITUTE (NCI) SYMPOSIUM: start-up s .EW 0) ATTRACTING STUDENTS AND POST DOCS PREPARING FOR TENURE The Role of NKG2D in Immune Responses to Tumors s -ID #AREER DEVELOPING ADMINISTRATIVE AND MANAGEMENT SKILLS FRIDAY, MAY 8, 2:00 – 4:00 PM sabbaticals s #HANGING #AREERS MOVING FROM ACADEMIA TO INDUSTRY OR VICE VERSA Chair: David H. Raulet, University of California, Berkeley Special Co-Chair: T. Kevin Howcroft, Division of Cancer Biology and Cancer Topics for unique situations Immunology, NCI, NIH s #AREER AND &AMILY TIME MANAGEMENTFAMILY LEAVEPROFESSIONAL Thomas Spies, Fred Hutchinson Cancer Research Center, NKG2D-mediated couples suppression of tumor immunity s )NTEGRITY AND %THICS DEALING WITH CONTROVERSY DISCRIMINATION IN THE David H. Raulet, University of California, Berkeley, Regulation of NKG2D workplace ligands and the role of NKG2D in tumor surveillance s !LTERNATIVE #AREERS SCIENCE JOURNALISM PATENT LAW Lewis L. Lanier, University of California, San Francisco, NKG2D-mediated s 4HE 3CIENTISTS 2OLE IN 0UBLIC 0OLICY immune responses s 4IME -ANAGEMENT Glenn Dranoff, Dana-Farber Cancer Institute, Targeting the NKG2D path- Registration, $10 fee required; dessert buffet and coffee included way in cancer therapy
MINORITY AFFAIRS COMMITTEE NATIONAL INSTITUTE ON AGING (NIA) SYMPOSIUM: Careers and Networking Roundtable How Aging Impacts Vaccine Efficacy SUNDAY, MAY 10, 11:00 AM – 12:30 PM SUNDAY, MAY 10, 8:00 – 10:00 AM Chair: Randy R. Brutkiewicz, Indiana University School of Medicine, Chair: Rebecca A. Fuldner, NIA, NIH Chair, AAI Minority Affairs Committee Co-Chair: Janko Nikolich-Zugich, University of Arizona College of Medicine and Arizona Center on Aging Don’t miss this opportunity to meet one-on-one with senior minority immunologists to hear how they have handled the career challenges you Donna M. Murasko, Drexel University, Immune response to influenza now face. Learn what they believe will work for you today. in the aged: a story of mice and men Jack Gorski, BloodCenter of Wisconsin, The aging of cytotoxic T cell Registration, $10 fee required; box lunch included memory to influenza Minority Affairs Committee Guest Lecture Janko Nikolich-Zugich, University of Arizona College of Medicine and Arizona Center on Aging, How the frail fail: immune response to acute MONDAY, MAY 11, 11:30 AM – 12:30 PM and chronic viral infections in old age Chair: Randy R. Brutkiewicz, Indiana University School of Medicine, Joseph Lustgarten, Mayo Clinic, Implications of aging and self tolerance Chair, AAI Minority Affairs Committee for the development of tumor vaccines in the elderly Emil R. Unanue, Washington University (St. Louis) School of Medicine, The mysteries of peptide selection by the class II MHC molecules IMMUNOLOGY 2009™
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS American Association of Veterinary Immunologists (AAVI) DISEASES (NIAID) and AAI Veterinary Immunology Committee Joint Symposium Contemporary Topics in Immunology Comparative Biology of Non-Classical MHC Class I Molecules FRIDAY, MAY 8, 2:00 – 4:00 PM SUNDAY, MAY 10, 12:30 – 2:30 PM Chairs: Alison Deckhut Augustine, NIAID, NIH; John G. Monroe, Genentech, Inc., AAI Program Chair Chairs: Christopher J. Davies, Utah State University; Mark A. Jutila, Montana State University, AAI Veterinary Immunology Committee Chair Michel Gilliet, University of Texas MD Anderson Cancer Center, Role of antimicrobial peptides in pDC-driven automimmunity Joan S. Hunt, University of Kansas Medical Center, Similar and dissimilar Hidde Ploegh, Whitehead Institute, Massachusetts Institute of Technology, features of human and baboon MHC class Ib antigens in placentas TLR9 requires proteolytic conversion for its activity Thaddeus G. Golos, University of Wisconsin, Towards in vivo models Julie Magarian Blander, Mount Sinai School of Medicine, Innate controls to define the functions of primate MHC class I molecules of TH17 and Treg cell differentiation Christopher J. Davies, Utah State University, Placental expression patterns Alan Aderem, Institute for Systems Biology, A systems approach to of cattle non-classical MHC class I genes and proteins dissecting immunity Laurent Abi-Rached, Stanford University, Species-specific evolution of NK cell receptors for MHC class I Working B Cells: How to Make Antibodies that Protect for Anti-HIV Vaccines American Society for Blood and Marrow Transplantation MONDAY, MAY 11, 10:15 AM – 12:15 PM (ASBMT) Chairs: Helen Quill, DAIT, NIAID, NIH; Tony Conley, DAIT, NIAID, NIH Allogeneic Hematopoietic Stem Cell Transplantation: Immunotherapy of Cancer Harry W. Schroeder, University of Alabama at Birmingham, Regulation SATURDAY, MAY 9, 8:00 – 10:00 AM of the primary antibody CDR-H3 repertoire and epitope selection in immunoglobulin responses to HIV Chair: Marcel R. M. van den Brink, Memorial Sloan-Kettering Leonidas A. Stamatatos, Seattle Biomedical Research Institution, Cancer Center Prevalence and epitope specificities of broadly-neutralizing antibodies Bruce R. Blazar, University of Minnesota, Graft-versus-host disease: generated during HIV-1 infection: how can we elicit them by vaccination? pathophysiology and prevention Abraham Pinter, UMDNJ-New Jersey Medical School, Targets for HIV-1 Jerome Ritz, Dana-Farber Cancer Institute, T and B cell responses to human neutralization—limitations and new approaches minor histocompatibility antigens Ignacio E. Sanz, University of Rochester, The cellular basis of protective Marcel R. M. van den Brink, Memorial Sloan-Kettering Cancer Center, anti-HIV antibody responses Adoptive therapy with T cell precursors Scientific progress in B cell biology relevant to the production of broadly Stanley R. Riddell, Fred Hutchinson Cancer Research Center, Establishing neutralizing anti-HIV-1 antibodies for the development of prophylactic persistent antitumor immunity after hematopoietic stem cell transplant vaccines: Scientific presentations of recent advances together with panel discussion of the unusual immunological issues involved and potential American Society of Bone and Mineral Research (ASBMR) solutions to roadblocks. Scientific presentation followed by a panel discussion. Osteoimmunology: Interactions of Bone and the Immune System GUEST SOCIETY SYMPOSIA SATURDAY, MAY 9, 2:45 – 4:45 PM AAI is joined by the following guest societies presenting two-hour symposia in special disciplines. Chairs: Mark C. Horowitz, Yale University School of Medicine; Joseph A. Lorenzo, University of Connecticut Health Center British Society for Immunology (BSI)–AAI Special Symposium Joseph A. Lorenzo, University of Connecticut Health Center, Introduction Immune Responses to Distressed Self to osteoimmunology MONDAY, MAY 11, 12:30 – 2:30 PM Mark C. Horowitz, Yale University School of Medicine, Interactions of bone and fat with the marrow Chairs: John G. Monroe, Genentech, Inc., AAI Program Chair; Amy J. Wagers, Joslin Diabetes Center, Regulation of stem cell function by Adrian H. Hayday, King’s College London School of Medicine, osteolineage niche cells BSI Secretariat Antonios O. Aliprantis, Harvard School of Public Health, NFATc1 uncouples Vincenzo Cerundolo, University of Oxford, Invariant NKT cells: effect osteoclastogenesis from inflammation in a mouse model of cherubism on DC, B cells and myeloid-derived suppressor cells Yueh-Hsiu Chien, Stanford University, From (the lack of) thymic selection American Society of Transplantation (AST) to IL-17 production: why GD T cells are indispensable Barriers to Transplant Tolerance Wayne Yokoyama , HHMI, Washington University (St. Louis) School SATURDAY, MAY 9, 12:30 – 2:30 PM of Medicine, NK cell tolerance: licensing and other mechanisms Benjamin E. Willcox, University of Birmingham, Immune display of the Chairs: Sheri M. Krams, Stanford University School of Medicine; cancer phosphoproteome: presentation of transformed self Robert L. Fairchild, Cleveland Clinic Foundation Vicki Seyfert-Margolis, Immune Tolerance Network, UCSF, Assays to measure transplant tolerance Olivia M. Martinez, Stanford University, Mechanisms of tolerance induction Leslie S. Kean, Emory University, Beyond rodents: achieving tolerance in primates Samuel Strober, Stanford University, Achieving tolerance safely in humans Association of Medical Laboratory Immunologists (AMLI) International Society for Interferon and Cytokine Research (ISICR) Human Immunology: Primary Immunodeficiencies Cytokines and Interferons in the Immune Response as Models for Understanding Lymphocyte Development MONDAY, MAY 11, 10:15 AM – 12:15 PM and Differentiation Chair: Robert M. Friedman, USUHS SUNDAY, MAY 10, 8:00 – 10:00 AM Patricia Fitzgerald-Bocarsly, UMDNJ, Interferons and plasmacytoid Chairs: Ronald J. Harbeck, National Jewish Health; Roshini S. Abraham, dendritic cells Mayo Clinic Grant Gallagher, HUMIGEN LLC, Modulation of the Th2 response Pamela L. Schwartzberg, NHGRI, NIH, Lessons from mouse models by IL-19 and interferon lambda of primary immunodeficiencies Thomas A. Wynn, NIAID, NIH, Dissecting alternative and classical activation: Jack J. H. Bleesing, Cincinnati Children’s Hospital Medical Center, the role of macrophage subsets in the pathogenesis of Th2-mediated disease Autoimmune lymphoproliferative syndromes: models for lymphocyte Kendall A. Smith, Weill Medical College of Cornell University, How mutations homeostasis and regulation in cytokine signaling pathways can lead to autoimmunity and leukemia Troy R. Torgerson, University of Washington and Seattle Children’s Re- search Institute, Immune dysregulation and primary International Society of Neuroimmunology (ISNI) immunodeficiencies: Foxp3 and Treg development B Cells in Neuroimmunologic Disease Jordan Orange, University of Pennsylvania School of Medicine and SATURDAY, MAY 9, 2:45 – 4:45 PM The Children’s Hospital of Philadelphia, The NK immunological synapse and NK-related immune deficiencies Chairs: Anne H. Cross, Washington University (St. Louis) School of Medicine; Bonnie N. Dittel, BloodCenter of Wisconsin, Blood Research Institute Canadian Society for Immunology (CSI) Bonnie N. Dittel, BloodCenter of Wisconsin, Blood Research Institute, Innate Regulation of Acquired Immunity Mechanisms utilized by B cells to regulate autoimmune inflammation SUNDAY, MAY 10, 12:30 – 2:30 PM in the CNS Scott S. Zamvil, University of California, San Francisco, Mechanisms Chairs: Jean S. Marshall, Dalhousie University; Kent T. HayGlass, of B cell involvement in CNS autoimmunity University of Manitoba Kevin C. O’Connor, Harvard Medical School, The specificity of B cells in the Jennifer L. Gommerman, University of Toronto, Interactions between CNS of multiple sclerosis patients stromal cells, dendritic cells, and lymphotoxin-expressing lymphocytes Anne H. Cross, Washington University (St. Louis) School of Medicine, tune the adaptive immune response B cell depletion in the therapy of relapsing multiple sclerosis Kent T. HayGlass, University of Manitoba, Linkages between TLR/NLR responsiveness and human allergic disease Singaporean Society for Immunology (SSI) Dana J. Philpott, University of Toronto, Nod proteins in innate and New Initiatives in Asia adaptive immunity SUNDAY, MAY 10, 10:15 AM – 12:15 PM Jean S. Marshall, Dalhousie University, Mast cell mobilization of dendritic cells Chairs: David Michael Kemeny, National University of Singapore; Paola Ricciardi Castagnoli, Singapore Immunology Network, A*STAR Chinese Society of Immunology (ChSI) David Michael Kemeny, National University of Singapore, CD8+ T cells Immune Regulation: From Basic to Clinics induce dendritic cell IL-12 in vitro and in vivo via CD40-dependent and SATURDAY, MAY 9, 10:15 AM – 12:15 PM independent pathways Paola Ricciardi Castagnoli, Singapore Immunology Network, A*STAR, Chairs: Xuetao Cao, Institute of Immunology, Second Military Medical Dendritic cells regulate immune responses via the NFAT signaling pathway University, Shanghai; Olivera (Olja) J. Finn, University of Pittsburgh S. K. Alex Law, Nanyang Technological University, Lessons from mutations School of Medicine of LAD patients and the structure and function of integrins Gang Pei, Institute of Biological Sciences, Chinese Academy of Sciences, Antonio Bertoletti, Singapore Institute for Clinical Sciences, A*STAR, Recon- Shanghai, Beta-arrestin 2 and negative regulation of innate and adaptive stitution of virus-specific immunity through TCR transfer in chronic hepatitis B immune response Paul A. MacAry, National University of Singapore, Targeting Epstein-Barr Sidong Xiong, Fudan University School of Medicine, Shanghai, DNA virus-associated tumors using TCR-like monoclonal antibodies for de novo autoantigen: when DNA could trigger autoimmunity Xiaoming Gao, Peking University Health Science Center, Beijing, Society for Glycobiology Specificity and function of regulatory anti-T-cell Abs induced by Glycans in Immune Development, Recognition, and Function T cell vaccination SATURDAY, MAY 9, 12:30 – 2:30 PM Hong Tang, Center for Immunity and Infection. Chinese Academy of Sciences, Beijing, Adaptive immune cells temper initial innate Chairs: Linda G. Baum, UCLA School of Medicine; Mitchell Kronenberg, responses La Jolla Institute for Allergy and Immunology Fusheng Wang, Beijing 302 Hospital, Beijing, Both regulatory T cells and Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, inhibitory receptors impair CD8+ T cell responses in chronic HBV infection Innate-like recognition of microbial glycolipids by natural killer T cells Yvette van Kooyk, Vrije Universiteit Medical Center, Amsterdam, Innate and adaptive dendritic cell responses upon glycan recognition James C. Paulson, The Scripps Research Institute, Targeting B cells with ligands of CD22 Linda G. Baum, UCLA School of Medicine, Galectin-glycan lattices on the plasma membrane regulate T cell function IMMUNOLOGY 2009™
Richard A. Pelroy, Program Director, NCI, The role of NIH institute Society for Leukocyte Biology (SLB) program officials in the grant process Macrophage Meets Microbe: Activation, Inflammation, Autophagy, and Cell Death Education Committee and National Postdoctoral Association SUNDAY, MAY 10, 2:45 – 4:45 PM Special Session: The Secrets to a Successful Postdoctoral Experience Chairs: Michele S. Swanson, University of Michigan Medical School; Brad T. Cookson, University of Washington MONDAY, MAY 11, 10:30 AM – 12:00 PM Thomas R. Hawn, University of Washington, TLR activation in combating Chair: Kira Gantt, AAI infection Karen Peterson, Director of the Office of Scientific Career Development, Russell E. Vance, University of California, Berkeley, Cytosolic Fred Hutchinson Cancer Research Center, The secrets to a successful immunosurveillance of Legionella pneumophila postdoctoral experience Michele S. Swanson, University of Michigan Medical School, Autophagy: a barrier to cytosolic infection Education Committee and Committee on the Status of Women Brad T. Cookson, University of Washington, Pyroptosis, a host-healthy Careers in Science: Lecture and Roundtable Discussion alternative to apoptosis SATURDAY, MAY 9, 1:30 - 3:30 PM Society for Mucosal Immunology (SMI) Chairs: Christine Milcarek, University of Pittsburgh, Chair, AAI Committee Enemies at the Gate: Control of Microbes at Mucosal Surfaces on the Status of Women; Bonnie N. Dittel, BloodCenter of Wisconsin, Blood SATURDAY, MAY 9, 2:45 – 4:45 PM Research Institute Speaker: Phyllis M. Wise, Provost and Executive Vice President, University Chairs: Leo Lefrançois, University of Connecticut Health Center; of Washington Charlotte S. Kaetzel, University of Kentucky College of Medicine Learn about career options and successful paths to each in this afternoon ses- Lora V. Hooper, HHMI, University of Texas Southwestern Medical School, sion. Following Dr. Wise’s lecture, experienced scientists will serve as roundtable Innate immune responses to commensal bacteria at the gut epithelial surface discussion leaders and offer one-on-one insight about specific career issues and Stephen J. McSorley, University of Minnesota Medical Center, Initiation options important to men and women in science today. Attendance will be limited of a CD4+ T cell response to Salmonella infection to the first 300 registrants. For the complete list of roundtable topics, visit David Artis, University of Pennsylvania School of Medicine, Innate www.IMMUNOLOGY2009.org/index.htm#CareerRoundtable. immune cells in the recognition and response to helminth parasites Registration, $10 fee required; dessert buffet and coffee included Linda S. Cauley, University of Connecticut Health Center, CD69 and CD103 cooperatively regulate CD8+ T cell responses in the lungs after influenza Minority Affairs Committee infection Careers and Networking Roundtable Dennis W. Metzger, Albany Medical College, The role of mucosal immunity SUNDAY, MAY 10, 11:00 AM – 12:30 PM in viral-bacterial synergistic lung infections Chair: Randy R. Brutkiewicz, Indiana University School of Medicine, Society for Natural Immunity (SNI) Chair, AAI Minority Affairs Committee NK Cell Development and Tolerance: Implications for Don’t miss this opportunity to meet one-on-one with senior minority Immunotherapy immunologists to hear how they have handled the career challenges SUNDAY, MAY 10, 2:45 – 4:45 PM you now face. Learn what they believe will work for you today. Registration, $10 fee required; box lunch included Chairs: Peter Parham, Stanford University; Michael A. Caligiuri, Ohio State University Publications Committee Fumio Takei, University of British Columbia, NK cell progenitors Course: Excellence in Scientific Writing in various tissues suggest multiple pathways of NK cell development FRIDAY, MAY 8, 12:00 – 4:00 PM Michael A. Caligiuri, Ohio State University, NK cell development Peter Parham, Stanford University, NK-cell immunogenetics: the art Improve the quality of your publications and grant applications. This interactive of fine tuning NK cell responses half-day workshop will, through examples and class participation, focus on the Jeffrey S. Miller, University of Minnesota, NK cell therapy in cancer essentials of effective writing and strategies for clear communication. Course is and transplantation limited to 100 attendees. Registration, $100 fee required CAREER DEVELOPMENT PROGRAMS Scientific Publishing: Dos and Don’ts for Authors and Reviewers AAI Education Committee Special Session SUNDAY, MAY 10, 12:30-2:30 PM The NIH Grant Maze: Navigating Old Turns and New Twists Chair: Robert D. Schreiber, Washington University (St. Louis) School SATURDAY, MAY 9, 10:30 AM – 12:15 PM of Medicine, Chair, AAI Publications Committee Chair: Barry P. Sleckman, Washington University (St. Louis) School Pamela J. Fink, University of Washington School of Medicine, of Medicine, AAI Education Committee Dos and don’ts when writing a scientific manuscript Barry P. Sleckman, Associate Professor, Washington University (St. Louis) JoAnne L. Flynn, University of Pittsburgh School of Medicine, School of Medicine, Introduction Essentials for becoming a valued reviewer Cheryl A. Kitt, Deputy Director, Center for Scientific Review, NIH, NIH grant Pamela A. Shaw, NIAID, NIH, The appropriate use of statistics in the rules, obligations and changes every PI should know: an overview from CSR biological sciences Gail A. Bishop, Professor, University of Iowa, Chair, TTT Study Section, Jeremy M. Boss, Emory University School of Medicine, What do Notes from a study section chair: what it takes to rise to the top you mean I already published it? Ethics in scientific publishing The American Association of Immunologists
AAI gratefully acknowledges the efforts of the AAI Program Committee in organizing IMMUNOLOGY 2009™
AAI 2008–2009 Program Committee
John G. Monroe, Chair Esteban Celis Genentech, Inc. H. Lee Moffitt Cancer Center & Research Institute Albert Bendelac HHMI,The University of Chicago Pamela L. Schwartzberg National Human Genome Nicholas R. J. Gascoigne Research Institute, NIH The Scripps Research Institute Ulrich H. von Andrian Christopher A. Hunter Harvard Medical School University of Pennsylvania School of Veterinary Medicine David Allman University of Pennsylvania Nigel Killeen School of Medicine University of California, San Francisco Hilde Cheroutre Ruslan M. Medzhitov La Jolla Institute for Allergy HHMI, Yale University School of Medicine & Immunology
Nancy Monson University of Texas Southwestern Medical Center at Dallas AAI Abstract Programming Chairs
AAI gratefully acknowledges the participation of the following AAI Abstract Programming Chairs for IMMUNOLOGY 2009™
ANTIGEN PROCESSING AND PRESENTATION HOST DEFENSE AND INNATE IMMUNITY James R. Drake Peter J. Murray 0ROFESSOR !LBANY -EDICAL #OLLEGE !SSOCIATE -EMBER 3T *UDE #HILDRENS 2ESEARCH (OSPITAL Joyce C. Solheim Rick L. Tarleton !SSOCIATE 0ROFESSOR 5NIVERSITY OF .EBRASKA -EDICAL #ENTER 0ROFESSOR 5NIVERSITY OF 'EORGIA
AUTOIMMUNITY IMMEDIATE HYPERSENSITIVITY, ASTHMA Anne Davidson AND ALLERGIC RESPONSES )NVESTIGATOR &EINSTEIN