ROS1 Polyclonal ANTIBODY Catalog Number:26960-1-AP

For Research Use Only ROS1 Polyclonal ANTIBODY www.ptglab.com Catalog Number:26960-1-AP Catalog Number: GenBank Accession Number: Purification Method: Basic Information 26960-1-AP NM_002944 Antigen affinity purification Size: GeneID (NCBI): 150UL 6098 Source: Full Name: Rabbit c-ros oncogene 1 , receptor tyrosine Isotype: kinase IgG Calculated MW: Immunogen Catalog Number: 264 kDa AG25722 Tested Applications: Applications ELISA Species Specificity: human ROS1, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v- Background Information ros from the UR2 sarcoma virus (PMID: 3023956). Investigators have found that rearrangements of the ROS1 gene occur in many cancers. The first oncogenic fusion of ROS1, FIG-ROS1, was initially identified by research studies in glioblastoma (PMID: 12661006), and subsequent studies have found this fusion in cholangiocarcinoma, ovarian cancer and non-small cell lung cancer (NSCLC) (PMID: 21253578, 22163003, 22661537). Additional oncogenic ROS1 fusion proteins have been found in NSCLC (at a frequency of 1-2%), including FIG, CD74, SLC34A2 and SDC4, and the list is growing. CD74-ROS1 is the most frequently detected ROS1 fusion in this group of patients. With all of the known fusion genes, the ROS1 kinase domain is fully retained and the ROS1 junction point at the messenger RNA (mRNA) level invariably occurs at the 5' end of exons 32, 34, 35 or 36 (PMID: 27535289). The molecular mass of some ROS1 fusion proteins are detected as follows: FIG-ROS1 (110 kDa), SLC34A2-ROS1 (85/70/59 kDa), CD74-ROS1 (80 kDa), and SDC4-ROS1 (75 kDa). (PMID: 22661537, 22659450) Storage: Storage Store at -20°C. Stable for one year after shipment. Storage Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Aliquoting is unnecessary for -20ºC storage For technical support and original validation data for this product please contact: This product is exclusively available under Proteintech T: 1 (888) 4PTGLAB (1-888-478-4522) (toll free E: [email protected] Group brand and is not available to purchase from any in USA), or 1(312) 455-8498 (outside USA) W: ptglab.com other manufacturer. Selected Validation Data.

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RET Gene Fusions in Malignancies of the Thyroid and Other Tissues
G C A T T A C G G C A T genes Review RET Gene Fusions in Malignancies of the Thyroid and Other Tissues Massimo Santoro 1,*, Marialuisa Moccia 1, Giorgia Federico 1 and Francesca Carlomagno 1,2 1 Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, 80131 Naples, Italy; [email protected] (M.M.); [email protected] (G.F.); [email protected] (F.C.) 2 Institute of Endocrinology and Experimental Oncology of the CNR, 80131 Naples, Italy * Correspondence: [email protected] Received: 10 March 2020; Accepted: 12 April 2020; Published: 15 April 2020 Abstract: Following the identification of the BCR-ABL1 (Breakpoint Cluster Region-ABelson murine Leukemia) fusion in chronic myelogenous leukemia, gene fusions generating chimeric oncoproteins have been recognized as common genomic structural variations in human malignancies. This is, in particular, a frequent mechanism in the oncogenic conversion of protein kinases. Gene fusion was the first mechanism identified for the oncogenic activation of the receptor tyrosine kinase RET (REarranged during Transfection), initially discovered in papillary thyroid carcinoma (PTC). More recently, the advent of highly sensitive massive parallel (next generation sequencing, NGS) sequencing of tumor DNA or cell-free (cfDNA) circulating tumor DNA, allowed for the detection of RET fusions in many other solid and hematopoietic malignancies. This review summarizes the role of RET fusions in the pathogenesis of human cancer. Keywords: kinase; tyrosine kinase inhibitor; targeted therapy; thyroid cancer 1. The RET Receptor RET (REarranged during Transfection) was initially isolated as a rearranged oncoprotein upon the transfection of a human lymphoma DNA [1].
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