J. Qian: Supplementary Table 3 1

Supplementary Table 3. Down-regulated in H6c7eR-Kr cells with signal log ratio <= -2 Signal Gene Unigene Log Ratio Symbol Title Hs.444340 -5 API5 apoptosis inhibitor 5 Hs.406492 -4.9 KIAA0738 KIAA0738 product Hs.75196 -4.7 BAT8 HLA-B associated transcript 8 Hs.402697 -4.6 EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 solute carrier family 35 (UDP-N-acetylglucosamine Hs.448979 -4.5 SLC35A3 (UDP-GlcNAc) transporter), member A3 Hs.95631 -4.5 MGC21654 unknown MGC21654 product Hs.108614 -4.3 CLASP2 cytoplasmic linker associated 2 Hs.323346 -4.3 DIS3 mitotic control protein dis3 homolog Hs.8086 -4.2 RNMT RNA (guanine-7-) methyltransferase DNA fragmentation factor, 40kDa, beta polypeptide Hs.133089 -4.2 DFFB (caspase-activated DNase) Hs.36927 -4 HSPH1 heat shock 105kDa/110kDa protein 1 Hs.1540 -3.9 THOC1 THO complex 1 Hs.5057 -3.8 CPD carboxypeptidase D ARHGAP1 Hs.396643 -3.8 2 Rho GTPase activating protein 12 Hs.54089 -3.7 BARD1 BRCA1 associated RING domain 1 Hs.80338 -3.7 BTF Bcl-2-associated transcription factor Hs.170114 -3.5 POP1 processing of precursors 1 Hs.55777 -3.5 FCMD Fukuyama type congenital muscular dystrophy (fukutin) Hs.89306 -3.4 FLJ20105 hypothetical protein FLJ20105 SWI/SNF related, matrix associated, dependent Hs.396404 -3.4 SMARCA2 regulator of chromatin, subfamily a, member 2 Hs.289007 -3.4 FLJ10803 hypothetical protein FLJ10803 Hs.17908 -3.3 ORC1L origin recognition complex, subunit 1-like (yeast) Hs.151202 -3.3 RB1CC1 RB1-inducible coiled-coil 1 Hs.66718 -3.3 RAD54L RAD54-like (S. cerevisiae) Hs.339 -3.3 P2RY2 purinergic receptor P2Y, G-protein coupled, 2 Hs.89497 -3.3 LMNB1 B1 Homo sapiens mRNA; cDNA DKFZp586K1123 (from Hs.26837 -3.2 --- clone DKFZp586K1123) Hs.440320 -3.2 CUL5 cullin 5 Hs.380994 -3.1 RBBP1 retinoblastoma binding protein 1 Hs.87491 -3.1 TYMS thymidylate synthetase Hs.192182 -3 SYK spleen tyrosine kinase nudix (nucleoside diphosphate linked moiety X)-type Hs.200016 -3 NUDT11 motif 11 J. Qian: Supplementary Table 3 2

Hs.54617 -2.9 FLJ20060 hypothetical protein FLJ20060 Hs.77502 -2.8 MAT2A methionine adenosyltransferase II, alpha Hs.440478 -2.8 ANK3 3, (ankyrin G) Hs.83765 -2.8 DHFR dihydrofolate reductase Hs.103982 -2.7 CXCL11 chemokine (C-X-C motif) ligand 11 Hs.2534 -2.7 BMPR1A bone morphogenetic protein receptor, type IA Hs.511992 -2.7 STAU2 staufen, RNA binding protein, homolog 2 (Drosophila) solute carrier family 35 (UDP-N-acetylglucosamine Hs.448979 -2.7 SLC35A3 (UDP-GlcNAc) transporter), member A3 Hs.180414 -2.7 HSPA8 heat shock 70kDa protein 8 Hs.74034 -2.6 CAV1 caveolin 1, caveolae protein, 22kDa Hs.363492 -2.6 DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 Hs.167741 -2.5 BTN3A3 butyrophilin, subfamily 3, member A3 Hs.78996 -2.5 PCNA proliferating cell nuclear antigen Hs.389539 -2.5 MDA5 melanoma differentiation associated protein-5 Hs.408177 -2.5 EFA6R ADP-ribosylation factor guanine nucleotide factor 6 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, Hs.418062 -2.4 B3GALT3 polypeptide 3 Hs.47122 -2.4 FPGT fucose-1-phosphate guanylyltransferase Hs.374524 -2.4 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 Hs.180414 -2.4 HSPA8 heat shock 70kDa protein 8 Hs.111554 -2.4 ARL7 ADP-ribosylation factor-like 7 Hs.111554 -2.4 ARL7 ADP-ribosylation factor-like 7 Hs.78853 -2.4 UNG uracil-DNA glycosylase Hs.436350 -2.4 ZNF302 zinc finger protein 302 Hs.27695 -2.4 MID1 midline 1 (Opitz/BBB syndrome) Hs.348920 -2.4 FSHPRH1 FSH primary response (LRPR1 homolog, rat) 1 Hs.180414 -2.3 HSPA8 heat shock 70kDa protein 8 Hs.73625 -2.3 KIF20A family member 20A Hs.421956 -2.3 AD024 AD024 protein MCM3 minichromosome maintenance deficient 3 (S. Hs.179565 -2.3 MCM3 cerevisiae) Hs.167741 -2.3 BTN3A3 butyrophilin, subfamily 3, member A3 Hs.82502 -2.3 POLD3 polymerase (DNA directed), delta 3 Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein Hs.288178 -2.3 SSA2 autoantigen SS-A/Ro) Hs.191435 -2.3 FDFT1 farnesyl-diphosphate farnesyltransferase 1 BUB1 budding uninhibited by benzimidazoles 1 Hs.287472 -2.3 BUB1 homolog (yeast) Hs.194665 -2.3 DNA2L DNA2 DNA replication helicase 2-like (yeast) Hs.512638 -2.3 TIP120A TBP-interacting protein J. Qian: Supplementary Table 3 3

zinc finger protein 45 (a Kruppel-associated box (KRAB) Hs.381285 -2.3 ZNF45 domain polypeptide) Hs.436593 -2.3 LMAN1 lectin, mannose-binding, 1 Hs.450060 -2.2 WWP1 WW domain-containing protein 1 Hs.22370 -2.2 nexilin likely ortholog of rat F-actin binding protein nexilin core 1 UDP-galactose:N-acetylgalactosamine-alpha-R Hs.134856 -2.2 C1GALT2 beta 1,3-galactosyltransferase 2 Hs.31968 -2.2 POT1 protection of telomeres 1 Hs.57664 -2.2 ITGB6 integrin, beta 6 Hs.87507 -2.1 BRIP1 BRCA1 interacting protein C-terminal helicase 1 Hs.105859 -2.1 FLJ10260 hypothetical protein FLJ10260 Hs.385685 -2.1 TRAF5 TNF receptor-associated factor 5 Hs.144906 -2.1 METAP2 methionyl aminopeptidase 2 CD44 antigen (homing function and Indian blood group Hs.306278 -2.1 CD44 system) Hs.348478 -2 PLSCR1 phospholipid scramblase 1 Hs.300624 -2 AF311304 hypothetical protein AF311304 Hs.23348 -2 SKP2 S-phase kinase-associated protein 2 (p45) Hs.7243 -2 USP24 ubiquitin specific protease 24 Hs.413671 -2 C14orf135 14 open reading frame 135 Hs.199695 -2 MAC30 hypothetical protein MAC30 Hs.444757 -2 KIF1B kinesin family member 1B Hs.71465 -2 SQLE squalene epoxidase Hs.64542 -2 CPSF6 cleavage and polyadenylation specific factor 6, 68kDa neurofibromin 1 (neurofibromatosis, von Recklinghausen Hs.93207 -2 NF1 disease, Watson disease) Hs.367676 -2 DUT dUTP pyrophosphatase Hs.23348 -2 SKP2 S-phase kinase-associated protein 2 (p45) Hs.446648 -2 AP3B1 adaptor-related protein complex 3, beta 1 subunit Hs.322903 -2 DIP2 disco-interacting protein 2 (Drosophila) homolog