JOURNAL OF

Volume 60 October 1986 No. 1

ANIMAL VIRUSES Exogenous Mouse Mammary Tumor Virus Proviral DNA Isolated from a Kidney Adenocarcinoma Cell Line Contains Alterations in the U3 Region of the Long Terminal Repeat. Raymund J. Wellinger, Madeleine Garcia, Annelyse Vessaz, and Heidi Diggelmann ...... 1-11 Translation and Processing of Mouse Hepatitis Virus Virion RNA in a Cell-Free System. Mark R. Denison and Stanley Perlman ...... 12-18 Initiation of Plus-Strand RNA Synthesis in a Membrane Complex of Infected HeLa Cells. Naokazu Takeda, Richard J. Kuhn, Chen-Fu Yang, Tsutomu Takegami, and ...... 43-53 Genetic Analysis of mRNA Synthesis in Adenovirus Region E3 at Different Stages of Productive Infection by RNA-Processing Mutants. Bheem M. Bhat and William S. M. Wold ...... 54-63 Two-Dimensional Polyacrylamide Gel Analysis of Plodia interpunctella Granulosis Virus. Darcy L. Russell and Richard A. Consigli ...... 82-89 Conserved Epitopes on the Hemagglutinin-Neuraminidase Proteins of Human and Bovine Parainfluenza Type 3 Viruses: Nucleotide Sequence Analysis of Variants Selected with Monoclonal Antibodies. Kathleen L. Coelingh, Christine C. Winter, Brian R. Murphy, Johh M. Rice, Paul C. Kimball, Robert A. Olmsted, and Peter L. Collins ...... 90-96 Organization of the Thymidylate Synthase Gene of Herpesvirus Saimiri. Walter Bodemer, Hans Helmut Niller, Nikolaus Nitsche, Brigitte Scholz, and Bernhard Fleckenstein ...... 114-123 Detection of a Genome-Linked Protein (VPg) of Hepatitis A Virus and Its Com- parison with Other Picornaviral VPgs. Manfred Weitz, Bahige M.

Baroudy, W. Lee Maloy, John R. Ticehurst, and Robert H. Purcell ...... 124-130 Promiscuous trans Activation of Gene Expression by an Epstein-Barr Virus- Encoded Early Nuclear Protein. Paul M. Lieberman, Peter O'Hare, Gary S. Hayward, and S. Diane Hayward ...... 140-148 Identification and Mapping of Epstein-Barr Virus Early Antigens and Demonstra- tion of a Viral Gene Activator That Functions in trans. Kam-Meng Wong and Arnold J. Levine ...... 149-156 Localization of Discontinuous Epitopes of Virus Glycoprotein D: Use of a Nondenaturing ("Native" Gel) System of Polyacrylamide Gel Elec- trophoresis Coupled with Western Blotting. Gary H. Cohen, Vicki J. Isola, Janet Kuhns, Phillip W. Berman, and Roselyn J. Eisenberg ...... 157-166 Use of Xgtll To Isolate Genes for Two Pseudorabies Virus Glycoproteins with Ho- mology to Herpes Simplex Virus and Varicella-Zoster Virus Glycoproteins. Erik A. Petrovskis, James G. Timmins, and Leonard E. Post ...... 185-193 Rearrangements and Insertions in the Moloney Long Terminal Repeat Alter Biological Properties In Vivo and In Vitro. Hung Fan, Shubhra Mittal, Hilary Chute, Euphemia Chao, and Paul K. Pattengale ...... 204-214 Continued on following page Continued from preceding page

Interspersed Homologous DNA of Autographa californica Nuclear Polyhedrosis Virus Enhances Delayed-Early Gene Expression. Linda A. Guarino and Max D. Summers ...... 215-223 Complete Sequence and Enhancer Function of the Homologous DNA Regions of Autographa californica Nuclear Polyhedrosis Virus. Linda A. Guarino, Mark A. Gonzalez, and Max D. Summers ...... 224-229 Positive and Negative Autoregulation of the Adeno-Associated Virus Type 2

Genome. Mark A. Labow, Paul L. Hermonat, and Kenneth I. Berns ..... 251-258 Murine Leukemia Virus Gene Products: Analysis with Antisera Generated against and Endonuclease Fusion Proteins Expressed in Escherichia coUl. Stella C. Hu, Donald L. Court, Martin Zweig, and Judith G. Levin ...... 267-274 Regulation of Polyomavirus Late Promoter Activity by Viral Early Proteins. Francis G. Kern, Sandra Pellegrini, Alison Cowie, and Claudio Basilico ... 275-285 A Recombinant Murine for Simian Virus 40 Large T cDNA Trans- forms Mouse Fibroblasts to Anchorage-Independent Growth. Myles Brown, Melissa McCormack, Kai G. Zinn, Michael P. Farrell, Ilan Bikel, and David M. Livingston ...... 290-293 Bovine Herpesvirus 1: Strain Comparison of Polypeptides and Identification of a Neutralization Epitope on the 90-Kilodalton Hemagglutinin. Pierre Trepanier, Harish C. Minocha, Yolande Bastien, Francine Nadon, Cecile Seguin, Gilles Lussier, and Michel Trudel ...... 302-306 An Immunodominant Domain in Adenovirus Type 2 Early Region 1A Proteins. Ann S. Tsukamoto, Blair Ferguson, Martin Rosenberg, Irving L. Weissman, and Arnold J. Berk ...... 312-316 Multiple 3' Ends of mRNA Encoding Virus Growth Factor Occur within a Series of Repeated Sequences Downstream of T Clusters. Leonard Yuen and Bernard Moss ...... 320-323 Identification of Coding Regions for Various Epstein-Barr Virus-Specific Antigens by Gene Transfer and Serology. Kenzo Takada, Norio Shimizu, Mieko Oguro, and Yasushi Ono ...... 324-330 Analysis of 15 Different Genome Types of Adenovirus Type 7 Isolated on Five Continents. Quan-Gen Li and Goran Wadell ...... 331-335

VIRUS-CELL INTERACTIONS Mammalian Cell Transformation by a Murine Retrovirus Vector Containing the Avian Erythroblastosis Virus erbB Gene. Arnona Gazit, Jacalyn H. Pierce, Matthias H. Kraus, Pier Paolo Di Fiore, Claire Y. Pennington, and Stuart A. Aaronson ...... 19-28 Isolation and Characterization of NIH 3T3 Cells Expressing Polyomavirus Small T Antigen. Tetsuo Noda, Masanobu Satake, Terry Robins, and Yoshiaki Ito 105-113 Site-Directed Mutagenesis of the gag-myc Gene of Avian Myelocytomatosis Virus 29: Biological Activity and Intracellular Localization of Structurally Altered Proteins. Mark L. Heaney, Jacalyn Pierce, and J. Thomas Parsons ...... 167-176 A New Acute Transforming Feline Retrovirus withfms Homology Specifies a C-Terminally Truncated Version of the c-fms Protein That Is Different from SM-Feline Sarcoma Virus v-fms Protein. Peter Besmer, Eric Lader, Patricia C. George, Peter J. Bergold, Fei-Hua Qiu, Evelyn E. Zuckerman, and William D. Hardy ...... 194-203 Continued on following page Continued from preceding page

BACTERIAL VIRUSES Topoisomerase II and Other DNA-Delay and DNA-Arrest Mutations Impair Bacteriophage T4 DNA Packaging In Vivo and In Vitro. Arthur Zachary and Lindsay W. Black ...... 97-104 Temperate Coliphage HK253: Attachment Site and Restricted Transduction of proAB Mutants of Escherichia coli K-12. Alice P. W. Poon and T. S. Dhillon ...... 317-319 VIRAL PATHOGENESIS AND IMMUNITY Replication of Human Cytomegalovirus in Human Peripheral Blood T Cells. Rudiger W. Braun and Hans C. Reiser ...... 29-36 Effect of Interferon on Replication of Herpes Simplex Virus Types 1 and 2 in Human Macrophages. Ingrid Domke-Opitz, Petra Straub, and Holger Kirchner ...... 37-42 Identification of Attenuating Mutations on the Reovirus Type 3 S1 Double-Strand- ed RNA Segment with a Rapid Sequencing Technique. Rhonda Bassel- Duby, Dale R. Spriggs, Kenneth L. Tyler, and Bernard N. Fields ...... 64-67 Generation and Characterization of a Recombinant Moloney Murine Leukemia Virus Containing the v-myc Oncogene of Avian MC29 Virus: In Vitro Transformation and In Vivo Pathogenesis. B. Kay Brightman, Paul K. Pattengale, and Hung Fan ...... 68-81 Critical Epitopes in Transmissible Gastroenteritis Virus Neutralization. Gustavo Jimenez, Isabel Correa, Mercedes P. Melgosa, Maria J. Bullido, and Luis Enjuanes ...... 131-139 Antibodies to pre-S and X Determinants Arise during Natural Infection with Ground Squirrel Hepatitis Virus. David H. Persing, Harold E. Varmus, and Don Ganem ...... 177-184 Tumor Progression in Murine Leukemia Virus-Induced T-Cell Lymphomas: Monitoring Clonal Selections with Viral and Cellular Probes. H. Theo M. Cuypers, Gerard C. Selten, Maarten Zijlstra, Rudd E. de Goede, Cees J. Melief, and Aton J. Berns ...... 230-241 Molecular Analysis and Pathogenesis of the Feline Aplastic Anemia Retrovirus, Feline Leukemia Virus C-SARMA. Norbert Riedel, Edward A. Hoover, Peter W. Gasper, Margery 0. Nicolson, and James I. Mullins ...... 242-250 Cell Receptors for the Mammalian Reovirus: Reovirus-Specific T-Cell Hybrido- mas Can Become Persistently Infected and Undergo Autoimmune Stimula- tion. Noboru Matsuzaki, Virginia S. Hinshaw, Bernard N. Fields, and Mark 1. Greene ...... 259-266 Pathogenicity of Herpes Simplex Virus Mutants Containing Drug Resistance Mutations in the Viral DNA Polymerase Gene. Hugh J. Field and Donald M. Coen ...... 286-289 Coxsackievirus B3 Infection Alters Plasma Membrane of Neonatal Skin Fibroblasts. Charles W. Lutton and Charles J. Gauntt ...... 294-296 Modulation of Humoral Response to a 12-Amino-Acid Site on the Poliovirus Virion. Joseph P. Icenogle, Philip D. Minor, Morag Ferguson, and James M. Hogle ...... 297-301 Reovirus Guanylyltransferase Is L2 Gene Product Lambda 2. Deborah R. Cleveland, Helmut Zarbl, and Stewart Millward ...... 307-311 Date of Issue: 17 September 1986