Sunscreen presentation

Isabella Fredenburg and Lucy Smith Fall 2019

Background Why are Important Discussion

Our designed molecule is:: ● They prevent skin cancer, precancers, wrinkles, sagging and ● Sunscreen molecules age spots[3] Our lambda max is calculated by: Base: 230 absorb ranges of UV ● There are a lot of different types of sunscreens that are Ortho benzene: 15 light wavelengths approved by the FDA, such sunscreen include Aminobenzoic Meta benzene: 15 that can be harmful acid, Avobenzone, and [4] NH group: 58

to skin and emit them Total lambda max: 318 Sunscreen Properties as IR wavelengths[1]. -PABA Derivative ● Sunscreens that How they work on a molecular level -Mostly Hydrophobic absorb UVC light -Will reflect UVA and UVB ● They can provide a barrier on the top of your skin to -High extinction coefficient absorbed wavelengths protect you from the sun[5] -Mostly planar ● The structure of the sunscreen determines which uv 200-250 nm, UVB light light it covers [5] in the range 250-350 ● The structure also Future Directions nm, and UVA between 350 determines how Future directions for this project include: often you have to and 400 nm[2]. apply and whether - developing a safe and environmentally friendly way to ● The five classes of sunscreen molecules are or not its waterproof[5] synthesize our sunscreen molecule. PABAs, Salicylates, Oxybenzones, Cinnamates, - Testing the chemical properties of the proposed molecule to and dibenzoal methanes. make sure it will function as a sunscreen. - Testing the proposed molecule for toxicity, consistency, and

smell. Factors to think about while designing a sunscreen ● Toxicity ● Stickiness Bibliography ○ You would want a non-toxic sunscreen so that it doesn’t make you sick. ○ You want a non-sticky sunscreen so nothing sticks [1]Adapted from http://www.3dchem.com/molecules.asp?ID=135#and to you. ● Skin membrane permeability http://members.aol.com/WSRNet/tut/absorbu.htm ○ You want it to be skin membrane permeable so that it can act like a second skin. ● Stable under various conditions [2]Adapted from http://www.3dchem.com/molecules.asp?ID=135#and ○ A sunscreen should be stable under the heat of the ● Smell http://members.aol.com/WSRNet/tut/absorbu.htm sun and in water. [3]Retrieved from https://www.aad.org/sun-protection/sunscreen-faqs. ○ If scents bother you, you might want to pick out of scent free sunscreen. ● Extinction Coefficient [4] Center for Drug Evaluation and Research. (n.d.). Sunscreen: How to Help Protect Your Skin from the ● Hydrophobicity ○ A high extinction coefficient in a sunscreen Sun. Retrieved from ○ You want it to be hydrophobic so that it doesn’t wash away easily, be sweat or water ensures that the molecule will absorb a large https://www.fda.gov/drugs/understanding-over-counter-medicines/sunscreen-how-help-protect-your-skin-s ● Conjugation and lamda max amount of light at a specified wavelength without un. [5] Daniellesays. (2015, June 26). The Science of Sunscreen & How it Protects Your Skin. Retrieved from ○ A good sunscreen covers UVA and UVB disintegrating. https://www.compoundchem.com/2014/06/05/sunscreenchemicals/.