REISHI LONGEVITY

TM

LEARN MORE AT www.easterncurrents.ca

MUSHROOM EXTRACT POWDER SCIENTIFICALLY VERIFIED QUALITY FOR ACTIVE COMPOUNDS GROWN NO GRAIN • NO STARCH • NO FILLERS

The information in this communication is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information does not create any patient-doctor relationship, and should not be used as a substitute for professional diagnosis and treatment. The statements made in this article have not been evaluated by the Food and Drug Administration or Health Canada. Any products mentioned are not intended to diagnose, treat, cure, or prevent any disease. Copyright© 2020 Real Mushrooms™ – All Rights Reserved – [email protected] TM REISHI / LONGEVITY p.2

Type Title Summary Link / Source Human Overview of Sinense This article urges availability of clinical study results of GSP tablet that Link Polysaccharide - An Adjunctive Drug would allow in-depth evaluation if the tablet is appropriate to serve as Used During Concurrent Chemo/ an immunomodulatory drug during cancer therapy at world stage. Radiation Therapy for Cancer Treatment in China Human Randomized Clinical Trial for the Children in the group receiving a yogurt with Beta-glucans presented a Link Evaluation of Immune Modulation by significantly higher absolute count of peripheral blood total lymphocytes Yogurt Enriched With Beta-Glucans (CD3+, CD4+, and CD8+ T cells) than that in the group receiving From or Reishi Medicinal placebo. Mushroom, (), in Children From Medellin, Colombia Human Ganoderma lucidum - from tradition Bronchial asthma improved by as much as 60-90% in some cases, Link to modern medicine espescially the older patients.

Human Studies on Ganoderma lucidum. I. It was therefore concluded that Ganoderma lucidum has blood-pressure Link Efficacy against Hypertension and lowering effect on patients with essential hypertension and will not have Side Effects any side effects on patients with essential or border line hypertension during six months oral intake. Human Ganoderma lucidum mushroom for Significant lowering of systolic and diastolic levels were noticed with 55 Link mg reishi plus hyerptension medications.

Human Ganoderma Lucidum (Reishi G. lucidum could be administered as an alternative adjunct to Link Mushroom) for Cancer Treatment conventional treatment in consideration of its potential of enhancing tumour response and stimulating host immunity. Human Clinical Characteristics of Gynecologic The present study reports the clinical data of 5 gynecologic cancer Link Cancer Patients Who Respond to patients who achieved stability in gynecological cancer. Salvage Treatment With Lingzhi Human Effects of Water-Soluble Ganoderma The results suggest that subgroups of cancer patients might Link lucidum Polysaccharides on the be responsive to Ganopoly in combination with chemotherapy/ Immune Functions of Patients with radiotherapy. Advanced Lung Cancer

Human Ganoderma lucidum improves physical After the 6-week treatment period, Ganoderma lucidum significantly Link fitness in women with fibromyalgia improved aerobic endurance, lower body flexibility, and velocity (p < .05).

Animal Effect of Ganoderma Lucidum on These results suggest that GL may be a useful therapeutic drug for Link Pollen-Induced Biphasic Nasal treating patients with allergic rhinitis. Blockage in a Guinea Pig Model of Allergic Rhinitis TM REISHI / LONGEVITY p.3

Type Title Summary Link / Source

Animal Studies on Ganoderma lucidum. VII: Reishi and anti-histamine release. Link Anti-allergic Effect (2)

Animal The Biologically Active Constituents The MeOH extract of Ganoderma lucidum ( Reishi ) has an inhibitory Link of Ganoderma Lucidum (Fr.) Karst. action on histamine release from rat mast cells. From the physiologically Histamine Release-Inhibitory active fraction of the extract, along with the known triterpenes Triterpenes ganoderic acids A and B, two new triterpenes were isolated and named ganoderic acids C and D.

Animal Effect of 26-oxygenosterols From These results demonstrate that the lanosterol 14alpha-demethylase, Ganoderma Lucidum and Their which converts 24,25-dihydrolanosterol to cholesterol, can be inhibited Activity as Cholesterol Synthesis by the 26- oxygenosterols from G. lucidum. These 26-oxygenosterols Inhibitors could lead to novel therapeutic agents that lower blood cholesterol.

In-vitro Dietary Effect of Ganoderma lucidum Although the exact mechanism for these effects was not known, our Link Mushroom on Blood Pressure results suggest that an appropriate dietary manipulation may prevent and Lipid Levels in Spontaneously the increase of blood pressure and reduce plasma and liver cholesterol Hypertensive Rats (SHR) levels in SHRs.

In-vitro Ganodermin, an Antifungal Protein Ganodermin inhibited the mycelial growth of Botrytis cinerea, Fusarium Link From Fruiting Bodies of the Medicinal oxysporum and Physalospora piricola with an IC50 value of 15.2 Mushroom Ganoderma Lucidum microM, 12.4 microM and 18.1 microM, respectively. It was devoid of hemagglutinating, deoxyribonuclease, ribonuclease and protease inhibitory activities.

Human Randomized Clinical Trial of an Ethanol The extract of G. lucidum was well tolerated and improved IPSS Link Extract of Ganoderma Lucidum scores. These results encouraged a further, large- scale evaluation of in Men With Lower Urinary Tract phytotherapy for a long duration using the extract of G. lucidum on men Symptoms with LUTS.

Animal T. Isolation and hypoglycemic activity “Reishi”, the fruit bodies of GANODERMA LUCIDUM, significantly Link of ganoderans A and B, glycans of decreased plasma sugar level in mice. Ganoderma lucidum fruit bodies

In-vitro Anticancer effect of triterpenes Reishi exerts its effect on cancer cells via numerous mechanisms and Link from Ganoderma lucidum in human may have potential therapeutic use for the prevention and treatment of prostate cancer cells cancer.

In-vitro Ganoderma lucidum stimulates NK Our results indicate that G. lucidum induces NK cell cytotoxicity against Link cell cytotoxicity by inducing NKG2D/ various cancer cell lines by activating NKG2D/NCR receptors and MAPK NCR activation and secretion of signaling pathways, which together culminate in exocytosis of perforin perforin and granulysin and granulysin. These observations provide a cellular and molecular mechanism to account for the reported anticancer effects of G. lucidum extracts inhumans.