17th Annual ISMRM Scientific Meeting and Exhibition 2009

Honolulu, Hawaii, USA 18 – 24 April 2009

Table of Contents and Author Index

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TABLE OF CONTENTS

TABLE OF CONTENTS

Volume 1

Multiparametric MR Guidance of Acute Stroke Treatment...... 1 A. Gregory Sorensen

The Role of MR in Promoting Long Term Recovery from Stroke ...... 2 Rudiger J. Seitz

MSK MRI: Technical Considerations...... 3 Garry E. Gold

Glenohumeral Joint Instabilty ...... 4 Christine Chung

Routine 3D MR Imaging of the Joints...... 16 Richard Kijowski

MR and Pathological Characterization of Breast Cancer ...... 20 Eva C. Gombos

Breast MRI Update on New Techniques: 3T vs.1.5T ...... 23 Mark A. Rosen

Assessment of Treatment Response...... 24 Constance D. Lehman

MR-guided Focused Ultrasound Surgery for Breast Cancer: Reliability and Effectiveness...... 27 Kiyoshi Namba

Three Dimensional Imaging of Ventilation Dynamics in Obstructive Lung Disease...... 31 James H. Holmes , Rafael L. O'Halloran , Ethan K. Brodsky , Thorsten A. Bley , Christopher J. Francois , Julia V. Velikina , Ronald L. Sorkness , William W. Busse , Sean B. Fain

3 Single Acquisition Time-Resolved T2 Mapping in Lungs Using HYPR He MRI...... 32 Katarzyna Cieslar, Achraf Al Faraj, Sophie Gaillard, Yannick Crémillieux

Single Breath-Hold 3D Q-Space Imaging of Lung Structures Using He-3 MRI...... 33 Rafael Luis O'Halloran , James H. Holmes , Yu-Chien Wu , Andrew L. Alexander , Sean B. Fain

In Vivo Lung Elastography with Hyperpolarized Helium-3 MRI...... 34 Xavier Maître , Ralph Sinkus , Roberta Santarelli , Mathieu Sarracanie , Rose-Marie Dubuisson , Emeline Boriasse , Emmanuel Durand , Luc Darrasse , Jacques Bittoun

Compressed Sensing for Hyperpolarized 3He 3D ADC Measurements ...... 35 Lise Vejby Søgaard, Torsten Dorniok, Frederik Hengstenberg, Sergei Karpuk, Jørgen Vestbo, Per Åkeson, Peter Magnusson

Parallel Acquisition as a Key for Rapid High Resolution 3He-ADC Imaging ...... 36 Maxim V. Terekhov, Julien Rivoire, Florian M. Meise, Davide Santoro, Wolfgang G. Schreiber

Compartment-Selective XTC MRI at 1.5T and 3T ...... 37 Kai Ruppert, Yulin Chang, Talissa A. Altes, Isabel M. Dregely, Stephen Ketel, Iulian C. Ruset, Jaime F. Mata, F William Hersman, John P. Mugler III

Non-Constrast Enhanced MRI of Lung Perfusion and Ventilation by Fourier Decomposition ...... 38 Grzegorz Bauman, Michael Puderbach, Michael Deimling, Vladimir Jellus, Christophe Chefd'hotel, Hans-Ulrich Kauczor, Lothar Schad

Ultra-Short Echo Time (UTE) MR Imaging of the Lung: Comparison Between Normal and Emphysematous Mice ...... 39 Masaya Takahashi, Osamu Togao, Makoto Obara, Marc van Cauteren, Yoshiharu Ohno, Craig Malloy, Makoto Kuro-o, Ivan Dimitrov

Functional MRI Using Arteriolar Cerebral Blood Volume Changes...... 40 Jun Hua, Qin Qin, Manus J. Donahue, Jinyuan Zhou, James J. Pekar, Peter CM van Zijl

Neuronal Activity-Induced Cerebral Blood Volume Changes in Humans: Measurements with VASO and VERVE...... 41 Claire Cohalan, Jean J. Chen, G. Bruce Pike

Whole-Brain Non-Invasive Hemodynamic Imaging, Enabled by a Novel CBV Weighted Single-Shot 3D VASO- FLAIR GRASE Sequence Combined with CBF-Weighted ASL and BOLD fMRI, Identifies Regional Hemodynamic and Metabolic Discrepancies...... 42 Manus J. Donahue, Jakob U. Blicher, Bradley J. MacIntosh, Karla L. Miller, Leif Ostergaard, David A. Feinberg, Matthias Guenther, Peter Jezzard

3D Single-Shot VASO fMRI Using a Maxwell-Gradient Compensated GRASE Sequence ...... 43 Benedikt Andreas Poser, David G. Norris

Studies of BOLD Signal Characteristics Using a Modified HASTE Sequence with GRAPPA...... 44 Yongquan Ye, Yan Zhuo, Rong Xue, Dehe Weng, Xiaohong Joe Zhou

A Parallel Transmission Method for Improved BOLD fMRI...... 45 Weiran Deng, Cungeng Yang, Vijayanand Alagappan, Lawrence L. Wald, V A. Stenger

Comparison of Template and Individual-Based Gradient Compensated EPI in Regions Affected by Local Susceptibility-Induced Signal Loss...... 46 Jochen Rick, Oliver Speck, Olaf Dössel, Jürgen Hennig, Maxim Zaitsev

Robust Detection of Functional Activation in the Superior Colliculus Without ECG-Triggering ...... 47 Ute Goerke, Kamil Ugurbil

Simultaneous Monitoring of Tongue Tip Movements in Functional MRI Motor Tasks for Speech and Swallowing Studies...... 48 Bradley P. Sutton, Charles A. Conway, David P. Kuehn

Investigating the Whole Brain with 1.5mm Isotropic Resolution and 1.5s TRs Using Highly Accelerated High-Field fMRI...... 49 Cheryl A. Olman, Steen Moeller, Jennifer F. Schumacher, Serena K. Thompson, Edward J. Auerbach, Kamil Ugurbil, Essa Yacoub

3T Contrast-Enhanced Whole Heart Coronary MRA Using 32-Channel Cardiac Coils for the Detection of Coronary Artery Disease ...... 50 Qi Yang, Kuncheng Li, Xiaoming Bi, Jing An, Feng Huang, Renate Jerecic, Debiao Li

In Vivo Human Coronary Magnetic Resonance Angiography at 7 Tesla...... 51 Saskia Gerdina van Elderen, Andrew G. Webb, Maarten J. Versluis, Jos J.M. Westenberg, Joost Doornbos, Nadine B. Smith, Albert de Roos, Matthias Stuber

3.0T Whole Heart Coronary MR Angiography Performed as a Part of Comprehensive Contrast Enhanced CMR Study ...... 52 Motonori Nagata, Hajime Sakuma, Nanaka Ishida, Shingo Kato, Hiroshi Nakajima, Masaki Ishida, Katsuya Onishi, Masaaki Ito, Kan Takeda

Contrast-Enhanced Whole-Heart Coronary MRA at 1.5T in Less Than 5 Minutes Using Gradient Echo Interleaved EPI and Double Dose of Gd-DTPA...... 53 Himanshu Bhat, Sven Zuehlsdorff, Xiaoming Bi, Xin Liu, Renate Jerecic, Debiao Li

Are We Reconstructing the Best Images Using Navigator-Gated 3D Coronary MRA? Multiple-Image Reconstruction Using CLAWS ...... 54 Permi Jhooti, Jennifer Keegan, Klaus Scheffler, David Firmin

Association of Coronary Calcification and Carotid Artery Morphology: A High Resolution Magnetic Resonance Imaging Study...... 55 Qian Zhao, Xihai Zhao, Feiyu Li, Qingjun Wang, Zulong Cai, Chun Yuan, Jianming Cai

Multi-Slice Breathhold Phase-Sensitive Coronary Vessel Wall Imaging at 3T...... 56 Khaled Z. Abd-Elmoniem, Matthias Stuber

Diagnostic Impact of Aortic MRI at 3Tesla in Acute Stroke Patients...... 57 Andreas Harloff, Stefanie Brendecke, Jan Simon, Wolf Wallis, Dawit Assefa, Thomas Helbing, Alex Frydrychowicz, Johannes Weber, Cornelius Weiller, Jürgen Hennig, Michael Markl

In Vivo Volumetric MRI in Drug Discovery: A Preclinical Study of the Ezetimibe Therapeutic Efficacy on Atherosclerotic Plaque Burden in the Thoracic Ascending Arterial Tree in ApoE-/- Mice ...... 58 Haiying Tang, Ching H. Chang, Donna Suresch, Lesley A. Mcnamara, Christopher Tong, Bernd Misselwitz, Dan Zhou, Brett M. Connolly, Jing Xu, Xun Chen, Xiaolan Shen, Chunlian Zhang, Eric L. Rickes, Michelle Mariano, Karim Azer, Jun Wang, Cyrille Sur, Donald S. Williams, Michael Klimas, Andrew S. Plump, Richard Hargreaves, Haiying Liu

Complex Plaques in the Descending Aorta as a Potential Source of Stroke – Visualization of Potential Retrograde Flow Into the Supra-Aortic Arteries Using Multi-Directional 4D Velocity Mapping at 3 Tesla...... 59 Andreas Harloff, Jan Simon, stefanie Brendecke, Wolf Wallis, Dawit Assefa, Alex Frydrychowicz, Johannes Weber, Jürgen Hennig, Cornelius Weiller, Michael Markl

Comparison of ASL and PWI Perfusion in Stroke Patients...... 60 Esben Thade Petersen, Tchoyoson C.C. Lim, N Venketasubramanian, Xavier Golay

3 T Pulsed Arterial Spin Labeling MRI Reveals Perfusion Deficits in Patients with Minor Stroke or Transient Ischaemic Attack ...... 61 Bradley J. MacIntosh, Alistair C. Lindsay, Ilias Kylintireas, Justin M. Lee, Matthew D. Robson, James Kennedy, Robin P. Choudhury, Peter Jezzard

Comparison of CBF Measurement by ASL and SPECT in Patients with Internal Carotid Artery Stenosis...... 62 Yoshito Uchihashi, Kohkichi Hosoda, Ivan Zimine, Atsushi Fujita, Satoshi Inoue, Hideo Aihara, Hideaki Kawamitsu, Nobukazu Aoyama, Hajime Aoki, Masahiko Fujii, Eiji Kohmura

Predictive Value of Structural Integrity of Affected Corticospinal Tracts in Motor Function Outcome of Affected Upper Extremities in Patients with Subcortical Ischemic Stroke: A Diffusion Spectrum Imaging Tractography Study ...... 63 Miao-Chi Lo, Yi-Hsin Ko, Pei-Fang Tang, Wen-Yih Isaac Tseng

Predicting Tissue Outcome in Acute Ischemic Stroke Using Projection Pursuit Regression ...... 64 Kartheeban Nagenthiraja, Kristjana Yr Jonsdottir, Leif Østergaard, Kim Mouridsen

ADC Values in the Corticospinal Tract at the Acute Stage Can Help Predict Stroke Outcome...... 65 Charlotte Rosso, Olivier Colliot, Christine Delmaire, Romain Valabregue, Sylvain Baillet, Sophie Crozier, Didier Dormont, Yves Samson, Stéphane Lehéricy

Identifying Stroke Patients Most Likely to Benefit from Reperfusion Therapy Using Acute MRI...... 66 Ona Wu, Søren Christensen, Niels Hjort, Anders Neumann, A Gregory Sorensen, Gotz Thomalla, Jens Fiehler, Thomas Kucinski, Joachim Rother, Leif Østergaard

Oxygen Metabolic Index as a Predictor of Tissue Viability in Acute Ischemic Stroke Patients ...... 67 Hongyu An, Andria L. Ford, Katie Vo, William J. Powers, Jin-Moo Lee, Weili Lin

Diffusion Time Dependent Kurtosis Maps Visualize Ischemic Lesions in Stroke Patients...... 68 Jimmy Lätt, Danielle van Westen, Markus Nilsson, Ronnie Wirestam, Freddy Ståhlberg, Stig Holtås, Sara Brockstedt

Functional MRI Exploration of Visuospatial Attention in Acute Neglect and Non-Neglect Stroke Patients ...... 69 Roza M. Umarova, Dorothee Saur, Christoph Kaller, Magnus-Sebastian Vry, Volkmar Glauche, Irina Mader, Cornelius Weiller

Investigating the Sources of Phase Contrast: Iron Oxide Nanoparticle Study to Exclude Deoxyhemoglobin as a Major Source for the Gray/white Matter Phase Contrast...... 70 Jongho Lee, Yoshiyuki Hirano, Masaki Fukunaga, Afonso Silva, Jeff H. Duyn

Susceptibility Weighted Imaging of the Human Brain at 9.4T ...... 71 Juliane Sabine Budde, Rolf Pohmann, Gunamony Shajan, Kâmil Ugurbil

Presurgical Visualization of Cerebral Surface Veins with Susceptibility Weighted Imaging ...... 72 Zeinab Al-Rekabi, Kelly McPhee, Kevin Fitzpatrick, Bruce Bjornson, Alexander Rauscher

Susceptibility and T2/T1 Weighted Contrast Enhancements in Rat Brain Using BSSFP at 9.4T...... 73 Joseph S. Gati, L Martyn Klassen, Robert Bartha, Ravi S. Menon

Cortical Layers Imaging with Inversion Recovery MRI ...... 74 Daniel Barazany, Ory Levy, Yaniv Assaf

Within Gray and White Mater R2 Variations Correlate Histochemical Iron Stain of the Human Brain...... 75 Masaki Fukunaga, Jongho Lee, Tie-Qiang Li, Kant K. Matsuda, Hellmut Merkle, Peter van Gelderen, Jacco A. de Zwart, Jeff H. Duyn

Detection and Delineation of Focal Cortical Lesions in Patients with Focal Epilepsy: Preliminary Results at 7T and 3T with 32 Channel Phased Arrays...... 76 Neel Madan, Thomas Benner, Elizabeth Anne Thiele, Emad N. Eskandar, Lawrence L. Wald, Patricia Ellen Grant

Three-Dimensional Segmentation of the Internal Structures of the Human Hippocampus at 7 Tesla ...... 77 Marie Chupin, Stephane Lehericy, Olivier Colliot, Malgorzata Marjanska, Ute Goerke, Kamil Ugurbil, Pierre-Francois Van de Moortele

Separation and Reproducibility of Touch Activations in Areas 3b and 1 Within the Primary Somatosensory Cortex by High Resolution fMRI at 7T...... 78 Elizabeth Ann Stringer, Robert M. Friedman, J Chris Gatenby, Li Min Chen, John C. Gore

Investigating the Effects of Hyperthyroidism on Cardiac Metabolism Using Hyperpolarized Magnetic Resonance ...... 79 Helen J. Atherton, Marie A. Shroeder, Lisa C. Heather, Julian L. Griffin, Kieran Clarke, George K. Radda, Damian J. Tyler

Hyperpolarized 13C MR Spectroscopic Imaging: Application to Brain Tumors ...... 80 Ilwoo Park, Peder E. Larson, Simon Hu, Robert Bok, Tomoko Ozawa, John Kurhanewicz, Daniel B. Vigneron, Scott R. VandenBerg, C David James, Sarah J. Nelson

Real-Time Cardiac Metabolism in a Pig Model of Cardiac Disease Using Hyperpolarized 13C MR...... 81 Angus Zoen Lau, Nilesh Ghugre, Albert P. Chen, Wilfred W. Lam, Venkat Ramanan, Yuesong Yang, Graham A. Wright, Charles H. Cunningham

13C-Labeled Malate as a Treatment Response Marker in a Murine Lymphoma Model in Vivo ...... 82 Rene in 't Zandt, Mikko Kettunen, Magnus Karlsson, Pernille Rose Jensen, Anna Gisselsson, Ferdia Gallagher, De Hu, Georg Hansson, Kevin Brindle, Mathilde Lerche

Hyperpolarized 1-[13C]-Ethyl-Pyruvate Metabolic Imaging in Anesthetized Rat Brain ...... 83 Ralph E. Hurd, Yi-Fen Yen, Dirk Mayer, Albert Chen, David Wilson, Susan Kohler, James Tropp, Robert Bok, Daniel Vigneron, John Kurhanewicz, Daniel Spielman, Adolf Pfefferbaum

Extending the Utility of Hyperpolarized Compounds by Storing Polarization in the Singlet State ...... 84 Elizabeth R. Jenista, Rosa T. Branca, Debadeep Bhattacharyya, Xin Chen, Warren S. Warren

Measuring Michaelis-Menten Kinetics of Hyperpolarized 13C1-Pyruvate Metabolism in a Single Bolus Injection ...... 85 Tao Xu, Dirk Mayer, Meng Gu, Yi-Fen Yen, Edvin Johansson, Jim Tropp, Ralph Hurd, Daniel Spielman

Imaging Brain PH Using Hyperpolarized 13C-Labeled Bicarbonate...... 86 Ferdia Aidan Gallagher, Mikko I. Kettunen, De-en Hu, Lorna B. Jarvis, Rebekah L. McLaughlin, Tim H. Witney, Sam E. Day, Jan H. Ardenkjaer-Larsen, Ken G. Smith, Kevin M. Brindle

Three Dimensional Acute Radiofrequency Ablation Lesion Visualisation and Correlation with Electro-Anatomical Mapping System Ablation Points...... 87 Benjamin R. Knowles, Dennis Caulfield, Aldo Rivaldi, Michael Cooklin, Jaswinder S. Gill, Julian Bostock, Reza Razavi, Tobias Schaeffter, Kawal S. Rhode

Four-Dimensional Transcatheter Intraarterial Perfusion MRI Monitoring of Chemoembolization for Hepatocellular Carcinoma...... 88 Dingxin Wang, Ron Gaba, Robert Lewandowski, Robert Ryu, Kent Sato, Mary Mulcahy, Riad Salem, Reed Omary, Andrew Larson

Initial Clinical Experience with a Robotic Assistance System for Liver Biopsies in a Diagnostic 1.5T MR Scanner...... 89 Michael Moche, Dirk Zajonz, Thomas Kahn, Harald Busse

MRI-Compatible Haptics: Strain Sensing for Real-Time Estimation of Three Dimensional Needle Deflection in MRI Environments...... 90 Yong-Lae Park, Santhi Elayaperumal, Seok Chang Ryu, Bruce Daniel, Richard J. Black, Behzad Moslehi, Mark R. Cutkosky

Passive Navigation Concept for MR-Assisted Orthopedic Interventions -Evaluation in Retrograde Drilling of Osteochondrosis Dissecans (OD) of the Talus ...... 91 Christian Jürgen Seebauer, Ulf Teichgräber, Florian Wichlas, Tobias Jung, Jens Rump, René Schilling, Thula Walther, Hermann Josef Bail

Real-Time Intravascular MRI Endoscopy at 3T ...... 92 Shashank Sathyanarayana, Michael Schär, Meiyappan Solaiyappan, Paul Arthur Bottomley

An Active Two Channel Guidewire for Interventional Cardiovascular MRI...... 93 Ozgur Kocaturk, Christina E. Saikus, Anthony Z. Faranesh, Michael A. Guttman, Kanishka Ratnayaka, Robert J. Lederman

Active Catheter Tracking in Air Cavities Using a Semisolid Signal Source...... 94 Stefan Alt, Reiner Umathum, Wolfhard Semmler, Michael Bock

A View-Sharing Compressed Sensing Technique for 3D Catheter Visualization from Bi-Planar Views ...... 95 Carsten Oliver Schirra, Steffen Weiss, Sascha Krueger, Reza Razavi, Sebastian Kozerke, Tobias Schaeffter

Outer Volume Suppression for Three Different Steady State Sequences Used in Percutaneous Interventions...... 96 Jaane Rauschenberg, Patrik Zamecnik, Wolfhard Semmler, Michael Bock

Morphological and Biochemical (T2) MR Evaluation and Comparison of Cartilage Repair Tissue of the Patella and the Medial Femoral Condyle ...... 97 Goetz Hannes Welsch, Tallal Charles Mamisch, Lukas Zak, Sebastian Quirbach, Stefan Marlovits, Siegfried Trattnig

Effect of Knee Alignment on T2 Relaxation Time of Articular Cartilage ...... 98 Risto Ojala, Riikka Partanen, Ilkka Hannila, Eveliina Lammentausta, Marianne Haapea, Osmo Tervonen, Miika T. Nieminen

Multiexponential T2 Analysis in Cartilage Degraded Using Different Enzymatic Protocols...... 99 David A. Reiter, Ligaya Roque, Richard G. Spencer

Evaluation of Cartilage T2 Using Loading in Situ MRI in Early Osteoarthritis with Hip Dysplasia ...... 100 Takashi Nishii, Toshiyuki Shiomi, Hisashi Tanaka, Youichi Yamazaki, Kenya Murase, Takashi Sakai, Masaki Takao, Hideki Yoshikawa, Nobuhiko Sugano

Localised Cartilage Assessment with Three-Dimensional DGEMRIC in Subjects with Normal and Cam-Type Abnormal Hip Joint Morphology. an Assay of Early Disease...... 101 Tom C B Pollard, Eugene G. McNally, Derek C. Wilson, Burkhard Maedler, David R. Wilson, Marion Watson, Andrew J. Carr

Factors Affecting Accuracy of T1 Estimates in Vivo by Variable Flip Angle Approach for dGEMRIC ...... 102 Angela Manuel, Wei Li, Vladimir Jellus, Timothy Hughes, Pottumarthi V. Prasad

Longitudinal Evaluation of Cartilage Degeneration in ACL-Injured Knees Using MR T1r Quantification and Laminar Analysis...... 103 Daniel Kuo, Alekos A. Theologis, Radu I. Bolbos, Julio Carballido-Gamio, ChunBong Benjamin Ma, Xiaojuan Li

Demonstration of the Pre-Clinical Efficacy of Aggrecanase Selective Inhibitor by T1p MRI ...... 104 Reddy Beesam Shashank, Ashwini Anumandla, Eric Albert Mellon, Jennifer H. Lee, Jingsong Wang, Ravinder Reddy

Ultrashort TE MRI of the Osteochondral Junction of the Knee at 3T:Identification of Anatomic Structures Contributing to Signal Intensity ...... 105 Won C. Bae, Jerry R. Dwek, Richard Znamirowski, Sheronda Statum, Juan C. Hermida, Darryl D. D’Lima, Robert L. Sah, Jiang Du, Christine B. Chung

Evaluation of Articular Cartilage of Lumbar Facet Joints with UTE MR Imaging and Multi-Echo SE T2 Mapping Techniques...... 106 Hatice Tuba Sanal, Tobias Mett, Sheronda Statum, Jiang Du, Richard Znamirowski, Graeme Bydder, Christine Chung

ISMRM 2009: Rise and Fall of the Brain 1: Developing Brain MRI of Normal Fetal Brain Development ...... 107 Catherine Limperopoulos

MRI of Fetal Developmental Anomalies...... 110 Nadine J. Girard

Cortical Folding and Connectivity in the Developing Brain...... 116 Petra S. Hüppi

Abnormalities Affecting Postnatal White Matter Development: Leukodystrophies...... 122 Florian Eichler

Soft Tissue Imaging: Neoplasm and Their Mimickers...... 123 David M. Panicek

Case Based Soft Tissue Imaging: Trauma...... 126 Mario Maas

Better Understanding Maturation Arrested Men Through HR-MAS Spectroscopy of Human Testicular Biospy Tissue ...... 128 Rahwa Berhanu Iman, Mark Swanson, Thomas Walsh, David Aaronson, Shoujun Zhao, Ying Lu, John Kurhanewicz

31P Chemical Shift Imaging of Testicular Infertility at 3.0 Tesla ...... 129 Jonathan P. Dyke, Darius A. Paduch, Joseph Kiper, Eric Aronowitz, Peter N. Schlegel, Douglas Ballon

Diffusion Weighted Imaging of Uterine Fibroids: Predicting Volumetric Response Following Uterine Artery Embolization ...... 130 Kinh Gian Do, Stella Kang, Timothy Clark, Elizabeth Hecht

Diffusion-Weighted MR Hysterography: Initial Evaluation and Determination of Optimal Imaging Timing During the Menstruation Cycle...... 131 Wenche M. Klerkx, Taro Takahara, Qvinny Leemans, Thomas C. Kwee, Peter Luijten, Willem P. Mali

Staging of Ovarian Cancer with Continuously Moving Table MR Acquisitions: A Comparison to Computed Tomography...... 132 Ute Ariane Ludwig, Gregor Pache, Tobias Baumann, Jürgen Hennig, Oliver Schäfer

The Role of 3 Tesla DWI in Evaluation of Primary and Metastatic Ovarian Cancer Before and After Neo- Adjuvant Chemotherapy ...... 133 Masako Yano Kataoka, Andrew Nicholas Priest, Martin J. Graves, Ilse Joubert, Robin Crawford, Helena Earl, James Brenton, Mary A. McLean, John R. Griffiths, David J. Lomas, Evis Sala

Tumour Necrosis Assessed by Magnetic Resonance Dynamic Contrast-Enhanced Subtraction Imaging Is a Predictor of Chemoradiotherapy Response in Advanced Cervical Cancer...... 134 Lorenzo Mannelli, Andrew N. Priest, Martin J. Graves, Ilse Joubert, Li Tee Tan, Robin Crawford, James Brenton, David J. Lomas, Evis Sala

Differentiation Between Malignant and Benign Cervical Tissue on the Basis of the Apparent Diffusion Coefficient Is Sensitive and Independent of the B-Value Combination Used for ADC Calculation...... 135 Jaap Hoogendam, Wenche Margrethe Klerkx, Gerard de Kort, Ronald Zweemer, Willem Mali, Wouter Veldhuis

High Resolution MR Imaging of the Fetal Heart with Cardiac Triggering: A Feasibility Study in the Sheep Fetus...... 136 Jin Yamamura, Bernhard Schnackenburg, Hendrik Kooijman, Michael Frisch, Gerhard Adam, Ulrike Wedegaertner

In-Vivo MRI Measurement of Fetal Blood Oxygen Saturation in Cardiac Ventricles of Fetal Sheep: A Feasibility Study ...... 137 Ulrike Wedegärtner, Hendrik Kooijman, Jin Yamamura, Michael Frisch, Kurt Hecher, Gerhard Adam

SWI-Based Intracranial MR Venography Using Image-Domain High-Pass Filtering with Second-Order Phase Difference ...... 138 Yiping P. Du, Zhaoyang Jin

3D Fast Inversion Recovery Magnetic Resonance Angiography (FIR-MRA)...... 139 Ek Tsoon Tan, John III Huston, Stephen J. Riederer

High Resolution, Non-Contrast Imaging of Both Cerebral Veins and Arteries by Use of Gradient Echo T2 Star Weighted Angiography (SWAN) ...... 140 Jennifer Linn, Jürgen Lutz, Michael Burke, Tim Wesemann, Hartmut Brückmann

Non Contrast MRA of the Extracranial Carotid Arteries Utilizing a 3D ECGTriggered Balanced Steady State Free Precession Technique with Spatial Saturation...... 141 Calvin Lo, Bidyut K. Pramanik, Daniel Kim, Xiaoming Bi, Peter Weale, Anna Nazarenko, Thomas P. Mulholland, Edmond A. Knopp, Vivian S. Lee, Ruth P. Lim

High Resolution 3D MR Angiography Using Arterial Spin Labeling ...... 142 Yi Wang, Seong-Eun Kim, Dennis L. Parker

4D Contrast Enhanced MRA with Flow Measurements (HYPR FLOW) in Arteriovenous Malformations ...... 143 Yijing Wu, Kevin M. Johnson, Elizabeth J. Nett, Patrick Turski, Charles A. Mistretta

4D-MRA in Combination with Selective Arterial Spin Labelling for Functional Characterization of Arteriovenous Malformations at 3 T...... 144 Guido Matthias Kukuk, Dariusch Reza Hadizadeh, Jürgen Gieseke, Julia Bergener, Gabriele Beck, Lisbeth Geerts, Petra Mürtz, Azize Boström, Horst Urbach, Johannes Schramm, Hans Heinz Schild, Winfried Albert Willinek

The Influence of k-t BLAST on Intracranial Aneurismal PC Velocity Mapping Data...... 145 Pim van Ooij, Joppe J. Schneiders, Marieke E.S. Sprengers, Ed van Bavel, Charles B.L.M. Majoie, Aart J. Nederveen

Cerebral Collateral Imaging in Patients with Carotid Stenosis Using MR Perfusion Territory Arterial Spin Labeling, Compared with DSA ...... 146 Bing Wu, Xiaoying Wang, Jia Guo, Eric C. Wong, Jue Zhang, Xuexiang Jiang

TOF MR Angiography at 3.0 Tesla During Acetazolamide Provocation Demonstrates Decreased Vasomotor Reactivity Ipsilateral to a Carotid Artery Stenosis...... 147 Reinoud Pieter Harmen Bokkers, Frank J. Wessels, H B. van der Worp, Jaco Zwanenburg, Jeroen Hendrikse

Foundations for Multi-Center Neuroimaging Studies...... 148 Gary H. Glover

How to do a STRUCTURAL Multi-Center Neuroimaging Study ...... 152 Matthew A. Bernstein

How to do a DTI Multi-Center Neuro-Imaging Study...... 159 Carlo Pierpaoli

How to do a Functional Multi-Center Neuro-Imaging Study...... 160 Bryon A. Mueller

How to do an ASL Multi-Center Neuro-Imaging Study ...... 163 Xavier G. Golay

How to do a Multi-Center Neuro-Imaging Study: A Technologist’s Perspective ...... 166 Maureen Ainslie

The Strength and Limitations of the Use of Transgenic and Knock-Out Animal Models...... 168 Frederick H. Epstein

High-Field MR Imaging of Mice Brain- Basic Requirements and Considerations...... 171 Stephen J. Blackband

Ultra Small Voxel Spectroscopy...... 172 Rolf Gruetter

Diffusion Imaging of Mouse Skeletal and Cardiac Muscle...... 174 Gustav Strijkers

Mouse Imaging with Whole-body MRI Scanners...... 179 Brian K. Rutt

The Design of Dedicated RF Coils for Mouse MR...... 185 Dennis W. J. Klomp

The Physics of MRI- Basic Spin Gymnastics...... 189 Walter Kucharczyk, Donald B. Plewes k-Space...... 201 Anja C. Brau

Cutting the Cord - Wireless Coils for MRI ...... 203 Oliver Heid, Markus Vester, Peter Cork, Peter Hulbert, David William Huish

A Generalized Analog Mode-Mixing Matrix for Channel Compression in Receive Arrays ...... 204 Jonathan Rizzo Polimeni, Vijayanand Alagappan, Thomas Witzel, Azma Mareyam, Lawrence Leroy Wald

Element Design for Increased Sensitivity in 64-Channel Wide-Field-Of-View Microscopy...... 205 Chieh-Wei Chang, Steve M. Wright, Mary Preston McDougall

Resonance Shift Decoupling: A Potential Alternative to Low Input Impedance Preamplifiers...... 206 Marc Stephen Ramirez, James Andrew Bankson

Studies on MR Reception Efficiency and SNR of Non-Resonance RF Method (NORM)...... 207 Xiaoliang Zhang, Chunsheng Wang, Daniel Vigneron, Sarah Nelson

The Shielding of RF MRI Coils Using Double-Sided EMI Shield...... 208 Ibrahim Abu El-Khair, Jan G. Korvink, Juergen Hennig, Gerhard Moenich

A 30 Channel Receive-Only 7T Array for Ex Vivo Brain Hemisphere Imaging ...... 209 Azma Mareyam, Jonathan Rizzo Polimeni, Vijayanand Alagappan, Bruce Fischl, Lawrence L. Wald

Multi-Purpose Flexible Transceiver Array at 7T ...... 210 Bing Wu, Chunsheng Wang, Roland Krug, Douglas Kelley, Yong Pang, Duan Xu, Sharmila Majumder, Sarah Nelson, Daniel Vigneron, Xiaoliang Zhang

A 32-Channel Receive Array Coil for Pediatric Brain Imaging at 3T ...... 211 Vijayanand Alagappan, Graham Charles Wiggins, Jonathan Rizzo Polimeni, Lawrence Leroy Wald

Hole-Slotted Phased Array at 7 Tesla ...... 212 Marcos A. Lopez, Philipp Ehses, Felix Breuer, Daniel Gareis, Peter Michael Jakob

MR Elastography of Dynamic Postprandial Hepatic Stiffness Augmentation in Chronic Liver Disease...... 213 Meng Yin, Jayant A. Talwalkar, Sudhakar K. Venkatesh, Richard L. Ehman

Carbogen Gas-Challenge BOLD MRI in Rat Liver Fibrosis Model ...... 214 Ning Jin, Jie Deng, Tamuna Chadashvili, Yue Zhang, Yang Guo, Guangyu Yang, Reed Omary, Andrew C. Larson

T1p-Based MR Imaging for the Non-Invasive Quantification of Extracellullar Matrix Protein Concentration in Hepatic Fibrosis ...... 215 Dania Daye, Chenyang Wang, Eric Mellon, Santosh Gaddam, Rebecca Wells, Emma Furth, Ravinder Reddy

In Vivo Assessment of Hepatic Ischemia/Reperfusion Injury in Rat Using Diffusion Tensor Imaging...... 216 Jerry S. Cheung, Shu Juan Fan, April M. Chow, Edward S. Hui, Ke Xia Cai, Kwan Man, Ed X. Wu

Combined T2-Weighted and MRCP 3D Imaging of the Abdomen Using a Dual-Contrast Single-Slab 3D-TSE Pulse Sequence ...... 217 John P. Mugler, III, Wilhelm Horger, Berthold Kiefer

MRCP After the Injection of Gd-EOB-DTPA: Are 3 Minutes Safe for T2 Weighted Navigated 3D MRCP?...... 218 Kristina Ringe, R Gupta, Angela Reichel, Thomas Rodt, Sabine Dettmer, Nils Hellige, Michael Galanski, Elmar M. Merkle, Joachim Lotz

Combining Diffusion-Weighted MR Imaging with Gd-EOB-DTPA Enhanced MR Imaging Improves the Detection of Colorectal Liver Metastases...... 219 Dow-Mu Koh, Toni Wallace, Erica Scurr, David J. Collins, Angela Riddell

Ultra High Spatio-Temporal Resolution Hepatic MRI Using a Novel 2-Point Dixon Time Resolved 3D SPGR Sequence at 3T ...... 220 Manojkumar Saranathan, Dan Rettmann, Ersin Bayram, Christine Lee, James Glockner

Diffusion-Weighted MR Imaging (DWI) Using TRacking Only Navigator Echo (TRON): Initial Clinical Evaluation and Comparison to Respiratory Triggered and Free Breathing DWI ...... 221 Thomas Kwee, Taro Takahara, Tetsuo Ogino, Gwen Herigault, Maarten van Leeuwen, Willem Mali, Peter Luijten

Clinical Liver MRI at 3.0 Tesla Using Parallel RF Transmission with Patient-Adaptive B1 Shimming...... 222 Guido Matthias Kukuk, Jürgen Gieseke, Michael Nelles, Roy König, Magnus Andersson, Eugen Muschler, Petra Mürtz, Jeroen Stout, Marco Nijenhuis, Frank Träber, Nuschin Morakkabati-Spitz, Daniel Thomas, Christiane Katharina Kuhl, Hans Heinz Schild, Winfried Albert Willinek

Resting State fMRI of Retinotopically Defined Sub-Regions in Human Visual Cortex...... 223 Egbert J. W. Bleeker, Hubert Fonteijn, Elena Shumskaya, Jens Schwarzbach, David G. Norris

Sources of fMRI Signal Variance in the Human Brain at Rest: A 7T Study...... 224 Marta Bianciardi, Masaki Fukunaga, Peter van Gelderen, Silvina G. Horovitz, Jacco A. de Zwart, Karin Shmueli, Jeff H. Duyn

Physiological Noise in Gradient Echo and Spin Echo EPI at 3T and 7T ...... 225 Christina Triantafyllou, Jonathan R. Polimeni, Mattijs Elschot, Lawrence L. Wald

Insights Into the Origin of Spontaneous Coherent BOLD Fluctuations in a Resting Rat Brain Under Varied Isoflurane Anesthesia Depth ...... 226 Xiao Liu, Xiao-Hong Zhu, Yi Zhang, Wei Chen

Spatiotemporal Correlation Between Alpha Modulation and BOLD Fluctuation in an Eyes-Open-Eyes-Closed Task...... 227 Lin Yang, Zhongming Liu, Cristina Rios, Han Yuan, Bin He

Functional MRI Study on Brain Plasticity Induced by Different Peripheral Nerve Injury Patterns: What Makes the Difference? ...... 228 Rupeng Li, Seth Jones, Christopher Pawela, Maida Parkins, Daniel Shefchik, Mark Bosbous, Ji-Geng Yan, Safwan S. Jaradeh, Hani S. Matloub, James S. Hyde

Development of the Brain Default Mode Network from Wakefulness Into Slow Wave Sleep ...... 229 Philipp G. Sämann, Renate Wehrle, Victor I. Spoormaker, David Höhn, Henning Peters, Florian Holsboer, Michael Czisch

Decoupling of the Default Mode Network During Deep Sleep ...... 230 Silvina G. Horovitz, Allen R. Braun, Walter S. Carr, Dante Picchioni, Thomas J. Balkin, Masaki Fukunaga, Jeff H. Duyn

Influence of Spontaneous BOLD Fluctuation on Stimulus-Evoked BOLD in Human Visual Cortex Using Event- Related Paradigm ...... 231 Xiao Liu, Xiao-Hong Zhu, Wei Chen

Resting-State Connections in Prefrontal Cortex Indicate Cognitive Network Efficiency During Working Memory...... 232 Jolyn Nicole Alexis D'Andrea, Bradley G. Goodyear

BISEP-Based, Ultra-Short TE 1H–[13C] NMR Spectroscopy of the Rat Brain at 14.1 T ...... 233 Lijing Xin, Bernard Lanz, Hanne Frenkel, Rolf Gruetter

High Acceleration 3D Compressed Sensing Hyperpolarized 13C MRSI of a Transgenic Mouse Model of Liver Cancer...... 234 Simon Hu, Asha Balakrishnan, Michael Lustig, Peder E Z Larson, Robert Bok, John Kurhanewicz, Sarah J. Nelson, John M. Pauly, Andrei Goga, Daniel B. Vigneron

rd Cost Function Guided 3 order B0 Shimming for MR Spectroscopic Imaging at 7T ...... 235 Jeroen Cornelis Willem Siero, Vincent Oltman Boer, Johannus Marinus Hoogduin, Peter R. Luijten, Dennis W. Klomp

Higher Order B0 Shimming of the Human Brain at 7T ...... 236 Hoby Patrick Hetherington, Andrey M. Kuznetsov, Nikolai I. Avdievich, Jullie W. Pan

A Comparison of Two Phase Correction Strategies in Multi-Channel MRSI Reconstruction ...... 237 Wei Bian, Jason C. Crane, Wonjoon Sohn, Ilwoo Park, Esin Ozturk-Isik, Sarah J. Nelson

High Resolution 31P Magnetic Resonance Spectroscopic Imaging with Polarization Transfer of Phosphomono and - Diesters in the Human Brain at 3T...... 238 Jannie Petra Wijnen, Tom W.J. Scheenen, Arend Heerschap

31P Exchange Sensitive Imaging in Human Brain at 7T...... 239 Jullie W. Pan, Nikolai Avdievich, Dennis Spencer, Hoby P. Hetherington

Improved 31P Saturation Transfer Approach for Imaging Cerebral ATP Metabolic Rates In Vivo...... 240 Xiao-Hong Zhu, Qiang Xiong, Yi Zhang, Wei Chen

Dual Band Water and Lipid Suppression for Multi-Slice MRSI of Human Brain at 3T...... 241 He Zhu, Ronald Ouwerkerk, Richard A.E. Edden, Michael Schär, Peter B. Barker

In Vivo Cross-Relaxation in ATP in Skeletal Muscle Measured by 31P Saturation Transfer MRS...... 242 Christine Nabuurs, Bertolt Huijbregts, Andor Veltien, Be Wieringa, Cees Hilbers, Arend Heerschap

Simultaneous MR and PET Imaging of Human Brain Tumors Using an Integrated MR-PET Scanner ...... 243 Ciprian Catana, Thomas Benner, Andre van der Kouwe, Dominique L. Jennings, Michael Hamm, Poe-Jou Chen, Ovidiu C. Andronesi, Elizabeth R. Gerstner, Larry Byars, Christian Michel, Josef Pfeuffer, Matthias Schmand, Bruce R. Rosen, A. Gregory Sorensen

Molecular Imaging of High-Grade Brain Tumors Using Endogenous Protein and Peptide-Based Contrast ...... 244 Zhibo Wen, Shuguang Hu, Fanheng Huang, Peter C.M. van Zijl, Jinyuan Zhou

Random Walk Model for Predicting Patterns of Microscopic Glioma Spread Using DTI: A Prospective Study ...... 245 AnithaPriya Krishnan, Delphine Davis, Paul Okunieff, Walter O'Dell

Contrast-Enhanced Three-Dimensional Whole-Brain Black-Blood Imaging for Efficient Detection of Small Metastases...... 246 Jaeseok Park, Eung Yeop Kim

New Diffusion Restriction Precedes the Development of Enhancing Tumor in Glioblastomas ...... 247 Ajay Gupta, Sahil Sood, Robert Young, Sasan Karimi, Zhigang Zhang, Andrei Holodny

The Value of MRS Detectable Lipids as Prognostic Markers in Paediatric Brain Tumours ...... 248 Martin Wilson, Carole Cummins, Leslie MacPherson, Yu Sun, Kal Natarajan, Nigel P. Davies, Theo N. Arvanitis, Risto A. Kauppinen, Andrew C. Peet

Possibilistic Classification of Brain Tumors by MRS Based on Functional Data Analysis and Subpattern Discovery ...... 249 Juan M García-Gómez, Irene Epifanio, Margarida Julià-Sapé, Daniel Monleón, Javier Vicente, Salvador Tortajada, Elies Fuster, Angel Moreno-Torres, Andrew Peet, Franklyn Howe, Bernardo Celda, Carles Arús, Montserrat Robles

Development of an MR Spectroscopic Index to Differentiate Tumor from Treatment Induced Gliosis ...... 250 Radhika Srinivasan, Jan Wooten, Jason C. Crane, Soonmee Cha, Suzanne Chang, Scott Vandenberg, John Kurhanewicz, Sarah J. Nelson

Targeted Use of 1H-MRS Is as Accurate as Histology in the Diagnosis of Glioblastoma Multiforme ...... 251 Greg Fellows, Alan James Wright, Naomi Sibtain, Philip Rich, Kirstie S. Opstad, Dominick J.O McIntyre, Brian Anthony Bell, John Griffiths, Franklyn Arron Howe

Sodium MRI and 1H MRS in the Diagnosis and Monitoring of Primary Brain Tumors...... 252 Fernando Emilio Boada, Yongxian Qian, Denise Davis, Frank Lieberman, Ronald Hamilton, Arlan Mintz, Eric Schwartz

Voxel Based Morphometric Analysis of the Gbx2 Mutant Mouse Phenotype via MEMRI ...... 253 Kamila Urszula Szulc, Brian J. Nieman, Roy V. Sillitoe, Alex L. Joyner, Daniel H. Turnbull

Myelin Mapping in Living Mice Using Magnetization Transfer and Manganese ...... 254 Takashi Watanabe, Jens Frahm, Thomas Michaelis

Changes in Callosal and Thalamic Connectivity Following Peripheral Nerve Damage to the Rodent Forepaw Detected with Manganese Enhanced MRI...... 255 Jason Tucciarone, Galit Pelled, Alan Koretsky

A Novel Method for Dynamic Manganese-Enhanced MRI ...... 256 Hanbing Lu, Steven Demny, William Rea, Yantao Zuo, Yihong Yang, Elliot A. Stein

In Vivo Tracing of Cortical Laminar Structure in the Rodent Olfactory System Using Manganese-Enhanced MRI (MEMRI)...... 257 Der-Yow Chen, Kai-Hsiang Chuang, Stephen Dodd, Alan Koretsky

Manganese Tract Tracing in Zebrafish ...... 258 Miriam Scadeng, David Julian Dubowitz, Nathan Gray, Ellen Breen

Manganese-Enhanced MRI and 1H MR Spectroscopy of the Hypothalamus in a Model of Dehydration Induced Anorexic Rats...... 259 Nathalie Just, Rolf Gruetter

MEMRI Study of Neonatal Hypoxic-Ischemic Injury in the Late Stage ...... 260 Iris Yuwen Zhou, Kevin C. Chan, Abby Y. Ding, Edward S. Hui, Ke Xia Cai, Ed X. Wu

Using Magnanese-Enhanced MRI to Monitor the Efficacy of Angiotensin Converting Enzyme Inhibitor Treatment in a Murine Myocardial Infarction ...... 261 Collier Gladin, Lynsa Nguyen, Christopher Middleton, Jimei Liu, Nathan Yanasak, Tom C.-C. Hu

MRI Monitored Uptake of Manganese in the Mouse During Continuous Administration Using Osmotic Infusion Pumps...... 262 Maria Rosario Sepulveda, Tom Dresselaers, Uwe Himmelreich, Frank Wuytack

Concurrent Field Monitoring Removes Distortions from In-Vivo DWI Data ...... 263 Bertram Jakob Wilm, Christoph Barmet, Nicola DeZanche, Peter Boesiger, Klaas Paul Pruessmann

Influence of Gradient Design on the Measurement of S/V Using DWI ...... 264 Frederik Bernd Laun, Bram Stieltjes

Addressing a Systematic Vibration Artefact in Diffusion-Weighted MR Images...... 265 Daniel Gallichan, Jan Scholz, Andreas J. Bartsch, Timothy E. Behrens, Matthew D. Robson, Karla L. Miller b-Matrix Correction Applied to High Resolution DTI...... 266 Murat Aksoy, Samantha Holdsworth, Stefan Skare, Roland Bammer

Consistent Signal for Non-CPMG Echo Trains ...... 267 James G. Pipe, Donglai Huo, Zhiqiang Li, Eric Aboussouan

Echo-Planar Diffusion-Tensor Imaging of Inner Field-Of-Views in the Human Brain and Spinal Cord Using 2D- Selective RF Excitations...... 268 Jürgen Finsterbusch

High-Resolution DWI Outside the CNS Using Reduced-FOV Single-Shot EPI ...... 269 Emine Ulku Saritas, Ajit Shankaranarayanan, Eric T. Han, Joelle K. Barral, Jin Hyung Lee, Dwight George Nishimura

Steady-State Diffusion-Weighted Imaging with Trajectory Using Radially Batched Internal Navigator Echoes (TURBINE) ...... 270 Jennifer Andrea McNab, Daniel Gallichan, Matthew D. Robson, Karla L. Miller

Steady-State Free Precession (SSFP) Diffusion Imaging Using 3D Rotating Spirals (3DRS) ...... 271 Jian Zhang, Chunlei Liu, Michael Moseley

Optimized EPI-DTI and TSE-DTI at 3 T and 7 T in the Brain ...... 272 Eric Edward Sigmund, David Gutman, Mariana Lazar, Jens H. Jensen, Joseph A. Helpern

Sequential Optimal Spoke Selection for Spoke Trajectory Based RF Pulses Design in Parallel Excitation...... 273 Chao Ma, Dan Xu, Kevin F. King, Zhi-Pei Liang

Sparse Parallel Transmit Pulse Design Using Orthogonal Matching Pursuit Method ...... 274 Dong Chen, Folkmar Bornemann, Mika W. Vogel, Laura I. Sacolick, Guido Kudielka, Yudong Zhu

Coping with Off-Resonance Effects and Gradient Imperfections in Parallel Transmission Experiments ...... 275 Johannes Thomas Schneider, Martin Haas, Jürgen Hennig, Sven Junge, Wolfgang Ruhm, Peter Ullmann

Parallel Transmission Method for Susceptibility Artifact and B1+ Inhomogeneity Reduction...... 276 Cungeng Yang, Weiran Deng, Vijay A. Alagappan, Lawrence L. Wald, V. Andrew Stenger

Joint Design of Excitation and Refocusing Pulses for Fast Spin Echo Sequences in Parallel Transmission ...... 277 Dan Xu, Kevin F. King

Robust Parallel Excitation Pulse Design...... 278 William Allyn Grissom, Adam B. Kerr, Pascal Stang, Greig Scott, John Pauly

SAR Hotspot Reduction by Temporal Averaging in Parallel Transmission ...... 279 Ingmar Graesslin, Julia Weller, Ferdinand Schweser, Bjoern Annighoefer, Sven Biederer, Ulrich Katscher, Tim Nielsen, Paul Harvey, Peter Börnert

Spectral-Spatial Pulse Design for Through-Plane Phase Precompensatory Slice Selection in T2-Weighted Functional MRI ...... 280 Chun-yu Yip, Daehyun Yoon, Valur Olafsson, Sangwoo Lee, William A. Grissom, Jeffrey A. Fessler, Douglas C. Noll

Design of High-Bandwidth Adiabatic RF Pulses Using the Shinnar Le-Roux Algorithm ...... 281 Priti Balchandani, John Pauly, Daniel Spielman

A VERSE Algorithm with Additional Acoustic Noise Constraints ...... 282 Sebastian Schmitter, Marco Mueller, Wolfhard Semmler, Michael Bock

MRI Contrast from Relaxation Along a Fictitious Field (RAFF)...... 283 Timo Liimatainen, Dennis Sorce, Michael Garwood, Shalom Michaeli

Balanced SSFP Profile Asymmetries Detect Small Frequency Shifts in White Matter ...... 284 Karla L. Miller, Peter Jezzard

Characterizing White Matter Pathology with Quantitative Magnetization Transfer Imaging: Insight from a Four- Pool Model...... 285 Ives R. Levesque, G. Bruce Pike

A New, Polynomial-Based (PARA)CEST Analysis Method with B0 Correction and Increased Sensitivity...... 286 Lan Lu, Tejas Shah, Mark A. Griswold, Chris A. Flask

1H-CEST and 19F MRI of Temperature-Responsive Liposomal Contrast Agents for Image Guided Drug Delivery...... 287 Jochen Keupp, Sander Langereis, Inge de Roos, Dirk Burdinski, Jeroen Pikkemaat, Holger Gruell

ZAPI Analysis of Z-Spectral Components in Acute Cerebral Ischemia ...... 288 Johanna Närväinen, Kimmo T. Jokivarsi, Penny Louise Hubbard, Olli H. Grohn, Risto A. Kauppinen, Gareth A. Morris

PCEST: Positive Contrast Using Chemical Exchange Saturation Transfer ...... 289 Elena Vinogradov, Todd C. Soesbe, James A. Balschi, Dean A. Sherry, Robert E. Lenkinski

Z-Spectrum Asymmetry : From 3T to 7T...... 290 Olivier E. Mougin, Ron Coxon, Penny A. Gowland

GlycoCEST Using FISPCEST...... 291 T.J. Shah, L. Lu, P.R. Ernsberger, C.A. Flask

Fast Image Reconstruction from Non-Cartesian Data...... 292 Philip J. Beatty

Image Reconstruction: Off-Resonance Effects and Correction ...... 296 Bradley P. Sutton

SAR Measurement...... 304 Daniel J. Schaefer

More on SAR- A Practical Guidance for MRI Users ...... 308 Franz Hebrank

Quantitative Neuro-anatomic and Functional Image Assessment: Quantitative Assessment of White Matter...... 310 Andrew L. Alexander

MRS Resonances as Indicators of Altered Phospholipid and Neutral Lipid Metabolism in Living Cells ...... 313 Franca Podo, Egidio Iorio

Mobile Lipids and Apoptosis...... 317 Kevin M. Brindle

Dynamics of NMR Visible Mobile Lipids (ML) in Cultured Cells ...... 321 Carles Arús

Tissue Engineering: From Research to Products ...... 323 Anthony Ratcliffe

Stroke: “A Brain Attack” ...... 324 Kei Yamada

Demyelination: “An Age Attack” ...... 327 Mara A. Rocca

Coronary MRA: Applications, Needs, and What About CTA?...... 330 Michael V. McConnell

Coronary Magnetic Resonance Angiography- 1.5T Techniques ...... 334 Matthias Stuber

Coronary MRA on 3.0T...... 339 Debiao Li

Techniques for Anatomic Imaging of Mouse Brain...... 341 Robia C. Pautler

Evaluation of Mouse Brain Development with MRI ...... 356 Daniel H. Turnbull

Low Back Pain: MR Findings without Clinical Significance ...... 360 Miriam A. Bredella

Clinical Abnormalities in Patients with Low Back Pain, Not Detectable on MR Images ...... 362 Michael T. Modic

Proton Based Lung MRI...... 363 Lothar R. Schad

Hyperpolarized Gas MRI of the Lungs...... 365 Bastiaan Driehuys

Probe Development: Fundamentals/Chemistry ...... 366 Silvio Aime

Probe Development: Biophysics and Validation...... 367 Klaas Nicolay

MR Molecular Probes in a Clinical Setting: Potential and Issues. Early Clinical Experience...... 368 Elmar Spüntrup

Recent Developments in Contrast-Enhanced Body MR Angiography...... 369 Thorsten Bley

Unenhanced Body MRA: Is it Good Enough? ...... 371 Henrik J. Michaely

Diffusion-Weighted MR Imaging (DW-MRI) in the Body: Techniques and Optimisation ...... 373 Dow-Mu Koh

Diffuse Liver and Kidney Disease: Value of Diffusion-weighted Imaging (DWI)...... 374 Bachir Taouli

Focal Abdominal Lesions: Added Value of Diffusion-weighted MRI ...... 378 Vincent Vandecaveye

Predicting and Monitoring Treatment Response with DWI ...... 380 Harrite C. Thoeny

Unraveling Mouse Glioma Heterogeneity with DCE-T1 MRI and 1H-CSI Metabolome Pattern Perturbation ...... 382 Rui Vasco Simões, Maria Luisa García-Martín, Teresa Delgado-Goñi, Silvia Lope-Piedrafita, Carles Arús

Metabolic Imaging of Cachectic Tumors...... 383 Marie-France Penet, Samata Kakkad, Dmitri Artemov, Zaver M. Bhujwalla

Magnetic Resonance Imaging Reveals the Progression, Regression and Indolence of in Situ Carcinoma in Transgenic Mice...... 384 Sanaz Arkani Jansen, Suzanne Conzen, Xiaobing Fan, Erica Markiewicz, Gillian Newstead, Gregory Karczmar

Novel Nitroimdazolyl Derivatives and Its Reduction Products Reveal Hypoxia in Cultures of C6 Cells Using 1H HR MAS ...... 385 Jesus Pacheco-Torres, Paloma Ballesteros, Sebastian Cerdan, Pilar Lopez-Larrubia

In Vivo Imaging of Tumor Hypoxia Using 19F MRS of Trifluoromisonidazole...... 386 Ellen Ackerstaff, Mihai Coman, Sean Carlin, Sean A. Burke, Kristen L. Zakian, Khushali Kotedia, Joseph O'Donoghue, Clifton C. Ling, Jason A. Koutcher

Molecular Characterization of the Relationship Between Hypoxia, Total Choline and Breast Cancer Stem Cell Markers ...... 387 Balaji Krishnamachary, Marie-France Penet, Sridhar Nimmagadda, Meiyappan Solaiyappan, Dmitri Artemov, Kristine Glunde, Arvind P. Pathak, Paul Winnard, Venu Raman, Martin Pomper, Zaver M. Bhujwalla

Glycine as a Biomarker in Brain Tumors...... 388 Valeria Righi, Dionyssios Mintzopoulos, Ovidiu C. Andronesi, Peter M. Black, A Aria Tzika

Initial Metabolomic Analysis of Glioblastoma Multiforme Subtypes by HRMAS ...... 389 Daniel Valverde-Saubí, Ana Paula Candiota, Maria Antònia Molins, Miguel Feliz, Óscar Godino, Juan Martino, Juan José Acebes, Carles Arús

Comparison of MRS with Fluorescence for Molecular Imaging and Determination of Phospholipase Isoforms ...... 390 Daniel-Joseph Leung, Theresa Mawn, Edward James Delikatny

Detection of Lung Metastases Using Hyperpolarized 3He MRI and Targeted Magnetic Nanoparticles – Histologic Validation and Detection Limits ...... 391 Rosa Tamara Branca, Zackary Cleveland, Boma Fubara, Challa Kumar, Carola Leuschner, Warren Sloan Warren, Bastiaan Driehuys

Simultaneous Estimation of Water-T2 and Fat Fraction Using a Single Breath Hold Radial GRASE Method...... 392 Christian Graff, Zhiqiang Li, Eric W. Clarkson, Chuan Huang, Ali Bilgin, Maria I. Altbach

Breath-Hold FSE for Accurate Imaging of Myocardial and Hepatic R2 ...... 393 Daniel Kim, Jens H. Jensen, Ed X. Wu, Sujit S. Sheth, Gary M. Brittenham

Hepatic Fat Quantification in Children Using Multi-Echo Gradient-Echo Imaging and Fat Spectral Modeling at 1.5 T...... 394 Masoud Shiehmorteza, Takeshi Yokoo, Gavin Hamilton, Mark Bydder, Manuel Rodriguez, Joel E. Lavine, Jeffrey B. Schwimmer, Claude B. Sirlin

Correlation of T1 and T2 Corrected Dual-Echo MRI Vs. MRS for Hepatic Fat Determination in a Multicenter Clinical Trial: Results of the Phase II Study of the MTP Inhibitor AEGR-733...... 395 Mark Rosen, Sarah Englander, Harish Poptani, Evan Siegelman, James Gimpel, Dena Flamini, Matthew Parris, Bill Sasiela, Bruce Hillman

Quantification of Abdominal Fat Accumulation During Hyperalimentation Using MRI ...... 396 Olof Dahlqvist Leinhard, Andreas Johansson, Joakim Rydell, Johan Kihlberg, Örjan Smedby, Fredrik H. Nyström, Peter Lundberg, Magnus Borga

Validation of Chemical Shift Based Fat-Fraction Imaging with MR Spectroscopy ...... 397 Sina Meisamy, Catherine DG Hines, Gavin Hamilton, Karl Vigen, Jean H. Brittain, Charles A. McKenzie, Huanzhou Yu, Scott K. Nagle, Yu Grace Zeng, Claude B. Sirlin, Scott B. Reeder

A Dynamic Study of Changes in Hepatic and Skeletal Muscle Lipid and Glycogen Levels, Due to 24h Starvation and Re-Feeding: A 1H and 13C MRS Study ...... 398 Mary Charlotte Stephenson, Sherif Awad, Elisa Placidi, Luca Marciani, Kenneth C. H. Fearon, Ian A. Macdonald, Robin C. Spiller, Penny A. Gowland, Peter Gordon Morris, Dileep N. Lobo

Spectrally-Modeled Hepatic Fat Quantification by Multi-Echo Gradient-Recalled-Echo Magnetic Resonance Imaging at 3.0T...... 399 Takeshi Yokoo, Masoud Shiehmorteza, Mark Bydder, Gavin Hamilton, Yuko Kono, Alexander Kuo, Joel E. Lavine, Claude B. Sirlin

Identification of Brown Adipose Tissue in Mice Using IDEAL Fat-Water MRI ...... 400 Houchun Harry Hu, Daniel L. Smith Jr. , Tim R. Nagy, Michael I. Goran, Krishna S. Nayak

On the Definition of Fat-Fraction for in Vivo Fat Quantification with Magnetic Resonance Imaging...... 401 Scott B. Reeder, Catherine DG Hines, Huanzhou Yu, Charles A. McKenzie, Jean H. Brittain

Quantification of CMRO2 and CBF Using Simultaneous NIRS and fMRI ...... 402 Sungho Tak, Jong Chul Ye

Evaluation of a New Quantitative BOLD Approach to Map Local Blood Oxygen Saturation ...... 403 Thomas Christen, Benjamin Lemasson, Nicolas Pannetier, Régine Farion, Christoph Segebarth, Chantal Rémy, Emmanuel L. Barbier

Does Global Cerebral Oxygen Metabolism Change During Hypercapnia and Hypocapnia in Awake Humans?...... 404 Jean J. Chen, G. Bruce Pike

CO2 Breathing Suppresses Cerebral Metabolic Rate of Oxygen ...... 405 Feng Xu, Uma Yezhuvath, Matthew R. Brier, John Hart Jr. , Michael A. Kraut, Clair Moore, Hanzhang Lu

CBF-CMRO2 Coupling in the Default Mode Network...... 406 Pan Lin, Jorge Jovicich, Simon Robinson

Changes in Arterial Oxygen Tension with Evoked Stimulation in the Rat Somato-Sensory Cortex: Implications for Quantitative fMRI...... 407 Alberto L. Vazquez, Mitsuhiro Fukuda, Seong-Gi Kim

A Comparison of Physiologic Modulators of fMRI Signals...... 408 Hanzhang Lu, Feng Xu, Uma S. Yezhuvath, Yamei Cheng, Rani Varghese

Comparison and Validation of fMRI Calibration Techniques...... 409 Rasmus Matthias Birn, Daniel Handwerker, Peter A. Bandettini

An Intra-Subject Investigation of the BOLD Contrast Mechanism in Response to Visual Stimulation and Breath Hold at 1.5T, 3.0T and 7.0T: Insight Into the Extravascular Sensitivity, Resolution-Dependence and Vascular Origins of BOLD Contrast ...... 410 Manus J. Donahue, Hans Hoogduin, Peter CM van Zijl, Peter Jezzard, Reinoud Pieter Harmen Bokkers, Matthias JP van Osch, Jaco J.M. Zwanenburg, Peter Luyten, Jeroen Hendrikse

Physiological Noise Effects on the Flip Angle Selection in BOLD fMRI...... 411 Jerzy Bodurka, Peter Bandettini

The Development of an MR Agent for Imaging of Malignant Micro-Calcification in Breast Cancer ...... 412 Kumar R. Bhushan, Elena Vinogradov, Ananth J. Madhuranthakam, Atshushi Takahashi, John V. Frangioni, Robert E. Lenkinski

Fluorine-19 MR Molecular Imaging of Angiogenesis on Vx-2 Tumors in Rabbits Using ανβ3-Targeted Nanoparticles ...... 413 Jochen Keupp, Shelton D. Caruthers, Jürgen Rahmer, Todd A. Williams, Samuel A. Wickline, Gregory M. Lanza

In Vivo Molecular MRI of Atherosclerotic Plaque Progression in Mice Using a Novel Elastin-Binding Contrast Agent ...... 414 Marcus R. Makowski, Ulrike Blume, Andrea J. Wiethoff, Christian Jansen, Joel Lazewatsky, Simon Robinson, Rene M. Botnar

MR Imaging of an Arachidonic Acid-Induced Mouse Model of Thrombosis Using an Activated Platelets-Targeted Paramagnetic Contrast Agent...... 415 Ahmed Klink, Eric Lancelot, Sébastien Ballet, Walter Gonzalez, Christelle Medina, Claire Corot, Jean-Etienne Fabre, Willem J.M Mulder, Ziad Mallat, Zahi A. Fayad

In Vivo CEST Imaging Using Eu(III)-Water Molecule Exchange System ...... 416 Tomoyasu Mani, Osamu Togao, Todd C. Soesbe, Masaya Takahashi, Allan Dean Sherry

Magnetization Transfer Detection of GFP: A New MRI Gene Reporter ...... 417 Carlos J. Perez-Torres, Cynthia A. Massaad, Faridis Serrano, Robia G. Pautler

Chimeric Ferritin as a Reporter for MRI...... 418 Bistra Iordanova, Clinton S. Robison, Eric T. Ahrens

In Vivo MR and PET Imaging of a Highly Sensitive Polymeric PARACEST Contrast Agent...... 419 Todd C. Soesbe, Yunkou Wu, Guiyang Hao, Xiankai Sun, A. Dean Sherry

Rational Design of a High Relaxivity MR Probe ...... 420 Luca Frullano, Peter Caravan

Well-Defined, Multifunctional Nanostructures of a Paramagnetic Lipid and a Lipopeptide for Macrophage Imaging ...... 421 M.H.F. Sanders, Esad Vucic, Nico A.J.M. Sommerdijk, Enzo Terreno, Francesca Arena

In-Vivo Measurement of Absolute Metabolite Concentrations Using the ERETIC Method ...... 422 Susanne Heinzer-Schweizer, Nicola De Zanche, Matteo Pavan, Giel Mens, Urs Sturzenegger, Anke Henning, Peter Boesiger

Simultaneous Localized in Vivo 1H and 15N MRS of Glutamine Synthesis in the Hyperammonaemic Rat Brain...... 423 Cristina Cudalbu, Bernard Lanz, Florence D. Morgenthaler, Yves Pilloud, Vladimir Mlynárik, Rolf Gruetter

Measurement of Glutathione (GSH) Using a Standard STEAM Sequence with Optimized (TE, TM) Parameters: Spectral Simulation, Phantom, and Human Experiments at 3T...... 424 Shaolin Yang, Yihong Yang

Simultaneous Quantitation of T2 and Concentration of Vitamin C and GSH in the Human Brain in Vivo Using Multiple Echo Time Double Editing with MEGA-PRESS at 4 and 7 T...... 425 Uzay Emir, Malgorzata Marjanska, Dinesh Deelchand, Pierre-Gilles Henry, Ivan Tkac, Melissa Terpstra

Measurement of N-Acetylaspartylglutamate in Human Brain by Difference Editing at 7.0 Tesla...... 426 Changho Choi, Subroto Ghose, Ivan Dimitrov, Deborah Douglas, Perry Mihalakos

GABA Concentration in Visual Cortex Correlates with Individual Differences in γ -Band Oscillation Frequency...... 427 Richard A. Edden, Suresh Daniel Muthukumaraswarmy, Derek K. Jones, Jennifer B. Swettenham, Krish D. Singh

Simplified 13C Metabolic Modeling for Simplified Measurements of Cerebral TCA Cycle Rate in Vivo...... 428 Julien Valette, Fawzi Boumezbeur, Vincent Lebon,

Phase Navigators for Localized MR Spectroscopy Using Water Suppression Cycling...... 429 Thomas Ernst, Jikun Li

Versatile Fitting Tool for Simultaneous Modeling of Spectral Arrays Using Prior Knowledge Restrictions in Two Dimensions ...... 430 Daniel Guo Quae Chong, Johannes Slotboom, Chris Boesch, Roland Kreis

31P Spectroscopic Imaging of Human Brain at 7T ...... 431 Jullie W. Pan, Nikolai Avdievich, Jonathan Knisely, Hoby P. Hetherington

White Matter NAA Levels and Very Long Chain Fatty Acid Levels in Asymptomatic Boys with X-Linked Adrenoleukodystrophy Undergoing Lorenzo’s Oil Therapy ...... 432 Asif Mahmood, Gerald V. Raymond, Michael J. Moser, Peter B. Barker

Increased NAA Concentration in the Restless Legs Syndrome: Possible Link to Hypomyelination...... 433 Byeong-Yeul Lee, Padmavathi Ponnuru, James R. Connor, Qing X. Yang

Alteration of T2 Relaxation and NAA Concentration in Schizophrenia Evaluated in Frontal White Matter at 3 T...... 434 Nuran Tunc-Skarka, Wolfgang Weber-Fahr, Mareen Hoerst, Susanne Englisch, Christine Esslinger, Dragos Inta, Alexander Guttschalk, Mathias Zink, Gabriele Ende

Investigation of Tract-Specific Myelin Content Measures from a Population Averaged Myelin Water Fraction Atlas ...... 435 Sean C. Deoni

Evaluation of Anatomical and Functional Connections Following Traumatic Brain Injury in Humans by Diffusion Tensor Imaging and Resting-State Functional Connectivity...... 436 Christine L. MacDonald, Nicholas Hubbard, Sanjeev Vaishnavi, Adrian Epstein, Abraham Snyder, Stephanie Chleboun, Joshua Shimony, Marcus Raichle, David Brody

Application of Diffusion Tensor Imaging to Better Understanding Pathogenesis of the Pelizaeus-Merzbacher Disease...... 437 Jeremy J. Laukka, Malek I. Makki, James Y. Garbern

Microbleed Detection in Traumatic Brain Injury at 3T and 7T: Comparing 2D and 3D Gradient-Recalled Echo (GRE) Imaging with Susceptibility-Weighted Imaging (SWI)...... 438 Kathryn E. Hammond, Janine M. Lupo, Duan Xu, Sri Veeraraghavan, Hana Lee, Adam Kincaid, Dan B. Vigneron, Geoffrey T. Manley, Sarah J. Nelson, Pratik Mukherjee

Analyzing White Matter Integrity Changes Associated with Posttraumatic Stress Disorder in Veterans ...... 439 Wang Zhan, Zhen Wang, Charles Marmar, Thomas Neylan, Yu Zhang, Susanne Mueller, Marzieh Nezamzadeh, Chris Ching, Michael Weiner, Norbert Schuff

White Matter Microstructure Abnormality in Autism Spectrum Disorders : A DTI Based Subdivided Corpus Callosum Study...... 440 Pei-Chin Chen, Kun-Hsien Chou, I-Yun Chen, Chun-Yi Lo, Hsuan-Hui Wang, Ya-Wei Cheng, Ching-Po Lin

B0 and B1 Correction Using the Inherent Degrees of Freedom of a Multi-Channel Transmit Array...... 441 Jeremiah Aaron Heilman, Jamal J. Derakhshan, Matthew J. Riffe, Natalia Gudino, Jean Tkach, Christopher A. Flask, Jeffrey L. Duerk, Mark A. Griswold

Sampling Strategies for MRI with Simultaneous Excitation and Acquisition ...... 442 Markus Weiger, Klaas Paul Pruessmann, Martin Tabbert, Franek Hennel

A New Short TE 3D Radial Sampling Sequence: SWIFT-LiTE...... 443 Jang-Yeon Park, Steen Moeller, Ryan Chamberlain, Michael Garwood

A Low Power Imaging Alternative to bSSFP...... 444 Walter R.T. Witschey, Ari Borthakur, Mark Elliott, Erin Leigh McArdle, Ravinder Reddy

Spin Locked Steady-State Free Precession Imaging...... 445 Walter R.T. Witschey, Ari Borthakur, Mark Elliott, Abram Voorhees, Ravinder Reddy

Sodium-MRI Using a Density Adapted 3D Radial Acquistion Technique...... 446 Armin Michael Nagel, Frederik Bernd Laun, Marc-André Weber, Christian Matthies, Wolfhard Semmler, Lothar Rudi Schad

3D Dynamic MRSI for Hyperpolarized 13C with Compressed Sensing and Multiband Excitation Pulses...... 447 Peder E. Z. Larson, Simon Hu, Michael Lustig, Adam B. Kerr, Sarah J. Nelson, John Kurhanewicz, John M. Pauly, Daniel B. Vigneron

Accelerated Slice-Encoding for Metal Artifact Correction ...... 448 Brian A. Hargreaves, Wenmiao Lu, Weitian Chen, Garry E. Gold, Anja C. Brau, John M. Pauly, Kim Butts Pauly

MR Imaging at Sub-Millisecond Frame Rates...... 449 Steven M. Wright, Mary P. McDougall

MR-Based Attenuation Correction for PET/MR...... 450 Matthias Hofmann, Florian Steinke, Ilja Bezrukov, Armin Kolb, Philip Aschoff, Matthias Lichy, Michael Erb, Thomas Nägele, Michael Brady, Bernhard Schölkopf, Bernd Pichler

High Resolution Phase Gradient Mapping as a Tool for the Detection and Analysis of Local Field Disturbances...... 451 Hendrik de Leeuw, Peter Roland Seevinck, Gerrit Hendrik van de Maat, Chris J.G. Bakker

Limit of Detection of Localized Absolute Changes in CBF Using Arterial Spin Labeling (ASL) MRI...... 452 Iris Asllani, Ajna Borogovac, Truman R. Brown, Joy Hirsch, John W. Krakauer

An Analytical Model of Diffusion and Exchange of Water in White Matter from Diffusion-MRI and Its Application in Measuring Axon Radii...... 453 Wenjin Zhou, David H. Laidlaw

SMRI Complex Framework for Evaluating Relative Gray and White Matter Group Differences...... 454 Lai Xu, Vince D. Calhoun,

Sensitive and Noise-Resistant Identification of Voxel-Wise Changes in Magnetization Transfer Ratio Via Cluster Enhancement and M-Estimator-Based Monte Carlo Simulation...... 455 Michael G. Dwyer, Niels Bergsland, Sara Hussein, Jacqueline Durfee, Bianca Weinstock-Guttman, Robert Zivadinov

A Method for Correcting Inter-Series Motion in Brain MRI for Auto Scan Plane Planning ...... 456 Xiaodong Tao, Sandeep Narendra Gupta

Development and Evaluation of a Quantitative Brain Atlas @1.5T and Its Application to MS ...... 457 Veronika Ermer, Heiko Neeb, N. Jon Shah,

Brain Tissue Segmentation Using Fast T1 Mapping ...... 458 Wanyong Shin, Geng Xiujuan, Hong Gu, Yihong Yang

Efficient Anatomical Labeling by Statistical Recombination of Partially Label Datasets...... 459 Bennett Allan Landman, John Anton Bogovic, Jerry Ladd Prince,

Plaque Biology ...... 460 Sanjay Rajagopalan

Syllabus: Atherosclerosis Imaging: Current Applications in Clinical Trials ...... 461 Chun Yuan

Atherosclerosis Imaging: Non-Contrast Techniques...... 462 Zahi Adel Fayad

Targeted Contrast Techniques...... 468 Patrick M. Winter

The Role of MRI/MRA in Abdominal Trauma ...... 471 Scott B. Reeder

MRI in Patients with Inflammatory Bowel Disease...... 473 Mukesh G. Harisinghani

Acute Abdominal Pain- Is there a Potential Role for MRI in the Setting of the Emergency Room (ER) in a Patient with Renal Calculi? ...... 474 Diego R. Martin

Pregnant Patients with Abdominal Pain...... 476 Ivan Pedrosa

High Temporal and Spatial Resolution Time-Resolved 3D CE-MRA of the Hands and Feet ...... 478 Clifton R. Haider, James F. Glockner, Anthony W. Stanson, Stephen J. Riederer

Highly Accelerated Contrast-Enhanced MR Angiography Using Ghost Imaging ...... 479 Robert R. Edelman, Ioannis Koktzoglou,

Radial Sliding Window Time Resolved MRA: Evaluation of Intrapulmonary Circulation Parameters in Pulmonary Arterial Hypertension...... 480 John J. Sheehan, Hyun Jeong, Amir Davarpanah, Cormac Farrelly, Randall Ramsy, Sanjiv Shah, Tim Carroll, James C. Carr

Contrast Enhanced MRA with Retrospective Selection of Acceleration Factor...... 481 Bing Wu, Richard Watts, Anthony Butler, Rick Millane, Philip Bones

MR Cerebral Angiography Using Arterial Spin Labeling for Dynamic Inflow Visualization and Vessel Selectivity...... 482 Weiying Dai, Philip M. Robson, Ajit Shankaranarayanan, David C. Alsop

Very Low Dose Time-Resolved MR Angiography...... 483 Gerhard Laub, Randall Kroeker, Derek Lohan, Paul Finn

HYPR-L0: a Hybrid Technique for CE MRA with Extreme Data Undersampling Factors...... 484 Julia V. Velikina, Alexey A. Samsonov

Nonenhanced 3D Breast MRA Using FBI and Time-SLIP...... 485 Mitsue Miyazaki, Pamera M. Otto, Hitoshi Kanazawa, Nobuyasu Ichinose, Satoshi Sugiura, Robert Anderson Anderson

Systematic Evaluation of Stereotatic Radiosurgery Effects in Metastasis and Acoustic Neurinomas Using MRI ...... 486 Cristian Tejos, M.E. Andia, P. Besa, J. Lorenzoni, A. Vieria, L. Meneses, P. Irarrazaval

Apparent Diffusion Coefficient Measures on MR Correlate with Survival in Glioblastoma Multiforme ...... 487 Gerard Thompson, John Robert Cain, Samantha Jane Mills, Alan Jackson

A Fully Automated Method for Predicting Glioma Patient Outcome from DSC Imaging. A Second Reference to Histopathology? ...... 488 Kyrre E. Emblem, Frank G. Zoellner, Atle Bjornerud

Acute Effects of Bevacizumab on Glioblastoma Vascularity Assessed with DCE-MRI and Relation to Patient Survival...... 489 Weiting Zhang, Teri N. Kreisl, Jeff Solomon, Richard C. Reynolds, Danial R. Glen, Robert W. Cox, Howard A. Fine, John A. Butman

A Composite Model of the Parametric Response Map Predicts Survival Independent of Radiographic Response in Patients with High Grade Glioma...... 490 Craig J. Galban, Thomas L. Chenevert, Daniel A. Hamstra, Charles R. Meyer, Pia Sundgren, Christina Tsien, Theodore S. Lawrence, Alnawaz Rehemtulla, Timothy D. Johnson, Brian D. Ross

R2 Response of Brain Tumors to Hyperoxic and Hypercapnic Respiratory Challenges at 3 Tesla ...... 491 Andreas Müller, Stefanie Remmele, Ingo Wenningmann, Frank Träber, Roy König, Hans Clusmann, Hannes Dahnke, Juergen Gieseke, Sebastian Flacke, Winfried A. Willinek, Hans H. Schild, Petra Mürtz

Functional Diffusion Maps Applied to FLAIR Abnormal Areas Are Valuable for the Clinical Monitoring of Recurrent Brain Tumors ...... 492 Benjamin M. Ellingson, Mark G. Malkin, Scott D. Rand, Devyani P. Bedekar, Kathleen M. Schmainda

Assessment of Anti-Angiogenic Treatment in Glioblastoma Using Arterial Spin-Labeling and Dynamic Susceptibility Contrast Perfusion MRI in a Phase II Trial ...... 493 Mei-Yun Wang, Wei-Ting Zhang, Poe-zhou chen, Thomas Benner, Divya S. Bolar, Tracy T. Batchelor, Rakesh K. Jain, A. Gregory Sorensen

Intravoxel Water Diffusion Heterogeneity of Human High-Grade Gliomas...... 494 Thomas Kwee, Craig Galban, Marko Ivancevic, Pia Sundgren, Christina Tsien, Larry Junck, Benjamin Hoff, Charles Meyer, Brian Ross, Thomas Chenevert

T1rho Imaging and Quantification of the Meniscus Using a T1rho -Prepared Ultrashort TE (T1rho -UTE) Sequence ...... 495 Jiang Du, Michael Carl, Atsushi M. Takahashi, Eric Diaz, Christine B. Chung, Eric Han, Graeme M. Bydder

Variability of Meniscal T2 Calculations Using Ultra-Short Echo (UTE) Imaging ...... 496 Matthew F. Koff, Atsushi Takahashi, Hollis Potter

Delayed Contrast Enhanced MRI of Meniscus ...... 497 Wei Li, Robert R. Edelman, Pottumarthi V. Prasad

Optimizing MR Signal Contrast of the TMJ Disk...... 498 Michael Carl, Hatice T. Sanal, Eric Diaz, Jiang Du, Olivier Maciej Girard, Sheronda Statum, Richard Znamirowski, Christine Chung

Mechanical and Biochemical Characterization of the Degenerated Rabbit Intervertebral Disc by MRI ...... 499 Deva D. Chan, Safdar N. Khan, Xiaojing Ye, Shane B. Curtiss, Munish C. Gupta, Eric Klineberg, Corey P. Neu

Assessing the Inververtebral Disc Via gagCEST ...... 500 Wen Ling, Galit Saar, Ravinder R. Regatte, Alexej Jerschow, Gil Navon

Sodium MRI of Intervertebral Disc Degeneration ...... 501 Chenyang Michael Wang, Erin McArdle, Walter Witschey, Mark Elliott, Ravi Reddy, Ari Borthakur

Correlation Between Apparent Diffusion Coefficient Values and Pfirrmann Grades of Lumbar Intervertebral Disc Degeneration ...... 502 Hon J. Yu, Shadfar Bahri, Lutfi Tugan Muftuler, Orhan Nalcioglu, Vance Gardner

Self-Coregistered T1ρ and Sodium MRI of Intervertebral Discs ...... 503 Chenyang Michael Wang, Walter Witschey, Erin McArdle, Mark Elliott, Ari Borthakur, Ravi Reddy

Degeneration of the Long Biceps Tendon of the Shoulder: Comparison of MR Imaging with Gross Anatomy and Histology...... 504 Florian M. Buck, Holger Grehn, Monika Hilbe, Silvana Manzanell, Juerg Hodler

Tagging Along with DICOM Format...... 505 Babak A. Ardekani

Software Tools & Resources at NIH: Overview of NITRC ...... 506 David N. Kennedy

Algorithms and Software for Image Segmentation ...... 508 Simon K. Warfield

Algorithms and Software for Image Coregistration...... 509 James Gee

Analyzing DCE-MRI Data ...... 510 Min-Ying Lydia Su

Techniques of Fat Suppression ...... 515 Ian Cameron

MRS of Fat ...... 522 Robert E. Lenkinski

Fat Quantification in the Liver ...... 525 Bachir Taouli

Whole Body Fat Segmentation...... 527 Andrew Laine

Fat in the Musculoskeletal System...... 528 Mark Schweitzer

Spin Echo...... 530 R. Scott Hinks

Gradient Echo Imaging...... 537 Brian A. Hargreaves

Fast Spin Echo Imaging ...... 538 Frank R. Korosec

Influence of Strong Static Magnetic Fields on Myocardial Mechanics: Evaluation Applying Ultra-Wideband Radar ...... 543 Florian Thiel, Mathias Hein, Jürgen Sachs, Ulrich Schwarz, Tomasz Lindel, Frank Seifert

Effects of 7 Tesla MRI Examination on Postural Stability...... 544 Jens Matthias Theysohn, Andreas K. Bitz, Oliver Kraff, Stefan Maderwald, Marcus Gerwig, Oliver Kastrup, Dagmar Timmann, Franz Schmitt, Harald H. Quick, Elke Ruth Gizewski, Michael Forsting, Mark E. Ladd, Susanne C. Ladd

Numerical Evaluation of SAR Within Whole-Body Pregnant Woman Models in MRI Birdcage Coil...... 545 Zhangwei Wang, George X. Xu, Victor Taracila, Jason Jin, Fraser J. Robb

Optimized Signal Intensity and T1r Based NMR Thermometry for Ultra-High Field RF Safety Applications...... 546 Devashish Shrivastava, Timo Liimatainen, Ute Goerke, Jeramy Kulesa, Timothy Hanson, Shalom Michaeli, J. Thomas Vaughan

Real-Time Global and Local SAR Monitoring for Parallel Transmission Systems...... 547 Ingmar Graesslin, Sven Biederer, Bjoern Annighoefer, Hanno Homann, Henry Stahl, Peter Vernickel, Ulrich Katscher, Dennis Glaesel, Paul Harvey

Safety and Initial Results with a Dedicated Human 7T Eye Coil...... 548 Peter A. Wassenaar, Kathryn Richdale, Katharine Teal Bluestein, John Christoforidis, Titus Lanz, Michael Vincent Knopp, Petra Schmalbrock

RF Safety Assessment of a 7T Head Coil Using Thermal Modeling with Discrete Vessels ...... 549 Astrid L.H.M.W. van Lier, Cornelis A.T. van den Berg, Dennis W.J. Klomp, Bas W. Raaymakers, Jan J. W. Lagendijk

Reduction of Implant RF Heating by Modification of Electric Field Distribution ...... 550 Yigitcan Eryaman, Haydar Celik, Burak Akin, Ergin Atalar

Detecting Unsafe Device Coupling Using Reversed RF Polarization ...... 551 William Overall, Pascal Stang, John Pauly, Greig Scott

Characterization of the Relationship Between MR-Induced Distal Tip Heating in Cardiac Pacing Leads and the Electrical Performance of Novel Filtered Tip Assemblies ...... 552 Robert S. Johnson, Holly Moschiano, Robert Stevenson, Scott Brainard, Sam Ye, Joseph E. Spaulding, Warren Dabney

Use of Cardiac Output to Improve Measurement of Tracer Input Function in Dynamic Contrast-Enhanced MRI...... 553 Jeff Lei Zhang, Henry Rusinek, Louisa Bokacheva, Qun Chen, Pippa Storey, Vivian S. Lee

Noninvasive Multimodality Imaging of the Tumor Microenvironment: Registered Dynamic 1H MRI and 18F PET Studies of a Preclinical Model of Tumor Hypoxia...... 554 HyungJoon Cho, Ellen Ackerstaff, Sean Carlin, Mihaela Lupu, Ya Wang, Asif Rizwan, Joseph O'Donoghue, Clifton Ling, John Humm, Pat Zanzonico, Jason Koutcher

Distinct Molecular Profiles Characterize Hypoxic Breast Tumor Regions Detected by Combined MRSI, Optical Imaging, and Imaging Mass Spectrometry...... 555 Erika R. Amstalden, Tiffany R. Greenwood, Zaver M. Bhujwalla, Venu Raman, Ronald M. A. Heeren, Kristine Glunde

3D Radial Multi Gradient Echo Dynamic MRI for Characterization of Microvasculature in Tumor Models Subjected to Respiratory Motion...... 556 Julien Vautier, Melanie Heilmann, Christine Walczak, Joël Mispelter, Andreas Volk

High Resolution MR Angiography of Tumors Using Iron-Oxide Contrast Agent ...... 557 Dmitri Artemov, Yoshinori Kato

Early DCE-MRI Findings Predict Tumor Volume Changes...... 558 Edward Ashton

Serial Assessment of Perfusion Parameters in Patients with GBM Following Anti-Angiogenic Therapy...... 559 Emma Essock-Burns, Janine M. Lupo, Susan M. Chang, Soonmee Cha, Sarah J. Nelson

Early Detection of Response to Antiangiogenic Therapy in Metastatic Clear-Cell Renal Cell Carcinoma with ASL MRI ...... 560 Ivan Pedrosa, Philip Robson, Rupal Bhatt, David McDermott, Michael B. Atkins, David Alsop

DCE-MRI Summary and Heterogeneity Statistics Predict Response to Combined Chemo- And Anti-VEGF Therapy...... 561 Chris James Rose, James Patrick O'Connor, Yvonne Watson, Caleb Roberts, Giovannni A. Buonaccorsi, Susan Cheung, Brandon Whitcher, Gordon Jayson, Alan Jackson, Geoffrey J. Parker

Flow Assessment Over All Heart Valves Simultaneously Using 3D Velocity-Encoded MRI with Retrospective Valve Tracking...... 562 Jos J.M. Westenberg, Stijntje D. Roes, Sebastiaan Hammer, Pieter J. van den Boogaard, Nina Ajmone Marsan, Jeroen J. Bax, Johan H.C. Reiber, Albert de Roos, Rob J. van der Geest

Pressure Gradient Wave Propagation in the Left Atrium and Left Ventricle During Early Diastole ...... 563 June Cheng Baron, Ben Esch, Jessica Scott, Mark Haykowsky, Ian Paterson, Richard Thompson

4D Flow of the Whole Heart and Great Vessels Using a Real Time Self Respiratory Gating Technique: A Validation Study ...... 564 Sergio Andres Uribe Arancibia, Philipp Beerbaum, Allan Rasmusson, Thomas Sorensen, Reza Razavi, Tobias Schaeffter

PC VIPR for Comprehensive Cardiovascular Evaluation in Congenital Heart Disease ...... 565 Christopher J. François, Elizabeth K. Nett, Benjamin R. Landgraf, Kevin M. Johnson, Shardha Srinivasan, John Carter Ralphe, Darren P. Lum, Oliver Wieben

Analysis of Aortic Hemodynamics After Treatment for Coarctation Using Flow-Sensitive 4D MRI at 3T...... 566 Alex Frydrychowicz, Daniel Hirtler, Raoul Arnold, Alexander Berger, Aurelien F. Stalder, Jelena Bock, Andreas Harloff, Mathias Langer, Jürgen Hennig, Michael Markl

Phase Contrast Ultra Short TE; a More Reliable Technique for Measurement of High Velocity Turbulent Stenotic Jets...... 567 Kieran O'Brien, Saul Myerson, Brett Cowan, Alistair Young, Matthew Robson

Three-Dimensional Assessment of Wall Shear Stress Distribution in the Carotid Bifurcation ...... 568 Michael Markl, Felix Wegent, Simon Bauer, Aurelien F. Stalder, Alex Frydrychowicz, Cornelius Weiller, Martin Schumacher, Andreas Harloff

Time-Resolved Blood Flow Quantification Without Gating...... 569 Michael C. Langham, Jeremy Magland, Felix W. Wehrli

Evidence Across CMR Sites and Systems of Phase-Contrast Background Velocity Offsets Requiring Correction for Accurate Regurgitant or Shunt Flow...... 570 Peter D. Gatehouse, Marijn P. Rolf, Martin J. Graves, Mark B. Hofman, John Totman, Beat Werner, Rebecca Quest, Yingmin Liu, Jochen von Spiczak, Matthias Dieringer, Juerg Schwitter, Jeanette Schulz-Menger, David N. Firmin, Philip J. Kilner

In Vivo Assessment of Carotid Wall Shear Rate Using Spiral Fourier Velocity Encoding ...... 571 Joao Luiz Azevedo Carvalho, Jon Fredrik Nielsen, Krishna Shrinivas Nayak

Short TE (15ms) Spectroscopic Imaging of the Human Brain at 7T Using Transceiver Arrays and B1 Shimming Based Localization...... 572 Hoby Patrick Hetherington, Andrey M. Kuznetsov, Nikolai I. Avdievich, Jullie W. Pan

Spectroscopic Imaging Using Wideband Parallel RF Excitation at 7T...... 573 Borjan Aleksandar Gagoski, Kawin Setsompop, Joonsung Lee, Vijay Alagappan, Michael Hamm, Axel vom Endt, Lawrennce Wald, Elfar Adalsteinsson

1H NMR Spectroscopy in the Human Brain in Vivo at 9.4 Tesla: Initial Results ...... 574 Dinesh K. Deelchand, Pierre-Francois Van de Moortele, Gregor Adriany, Peter Andersen, Kamil Ugurbil, Pierre-Gilles Henry

Spectroscopic SWIFT...... 575 Djaudat Idiyatullin, Curt Corum, Steen Moeller, Jutta Ellermann, Michael Garwood

Accelerated Proton Echo-Planar Spectroscopic Imaging Using Parallel Imaging and Compressed Sensing ...... 576 Ricardo Otazo, Daniel K. Sodickson, Akio Yoshimoto, Stefan Posse

Gradient Offset Independent Adiabatic Pulses for High-Field MR Spectroscopy on Clinical Scanners...... 577 Ovidiu Cristian Andronesi, Saadallah Ramadan, Eva Maria Ratai, Dominique Jennings, Carolyn Mountford, A. Gregory Sorensen

Application of HSn Low Peak B1 Adiabatic Refocusing Pulses to Hyperpolarized 13C Spectroscopic Imaging ...... 578 Simon Hu, Peder E. Larson, Adam B. Kerr, Douglas A. Kelley, James Tropp, John M. Pauly, John Kurhanewicz, Daniel B. Vigneron

Diffusion-Weighted Line-Scan Echo-Planar Spectroscopic Imaging for Improved Accuracy in Metabolite Diffusion Imaging ...... 579 Yoshitaka Bito, Koji Hirata, Toshihiko Ebisu, Yuko Kawai, Yosuke Otake, Satoshi Hirata, Toru Shirai, Yoshihisa Soutome, Hisaaki Ochi, Masahiro Umeda, Toshihiro Higuchi, Chuzo Tanaka

Improving Spatial Localization in MR Spectroscopic Imaging with PSF-Choice ...... 580 Lawrence Patrick Panych, Joseph R. Roebuck, Robert V. Mulkern, Yi Tang, Bruno Madore, Nankuei Chen

Enhanced Polyamine Detection at 7T as a Possible in Vivo Biomarker for Prostate Cancer ...... 581 Dennis Klomp, Tom Scheenen, Jack van Asten, Vincent Boer, Peter Luijten

High Resolution Magnetization Transfer Imaging at 7T...... 582 Olivier E. Mougin, Ali al-Radaideh, Ron Coxon, Emma C. Tallantyre, Matthew J. Brookes, Nikos Evangelou, Penny A. Gowland

Regions of Reduced Cortical Magnetization Transfer Ratio Detected in MS Patients Using Surface-Based Techniques...... 583 Mishkin Derakhshan, Zografos Caramanos, Sridar Narayanan, Donald Louis Collins, Douglas Lorne Arnold

Optimisation of 7T Double-Inversion Recovery (DIR) Imaging to Improve Detection of MS Lesions In Vivo...... 584 Jennifer Elizabeth Dixon, Paul S. Morgan, Matthew J. Brookes, Ali M. Al-Radaideh, Emma C. Tallantyre, Nikos Evangelou, Peter G. Morris

Detection of Cortical Lesions in Multiple Sclerosis Using FLAIR, DIR and Ultra High Field MPRAGE ...... 585 Emma Clare Tallantyre, Jennifer E. Dixon, Matthew J. Brookes, Ali Al-Radaideh, Paul S. Morgan, Nikos Evangelou, Peter G. Morris

Evaluation of Cortical Lesions Conspicuity in Multiple Sclerosis: 7T Vs 3T MRI ...... 586 Caterina Mainero, Thomas Benner, Amy Radding, Rikke Jensen, Andre van der Kouwe, R P. Kinkel, Bruce R. Rosen

High Resolution In-Vivo and Post-Mortem R2 and Phase Images of Multiple Sclerosis Lesions at 7 T ...... 587 Bing Yao, Francesca Bagnato, Hellmut Merkle, Peter van Gelderen, Fredric K. Cantor, Joan Ohayon, Henry McFarland, Jeff H. Duyn

Demyelination and Remyelination in New Multiple Sclerosis Lesions: Insights from Serial Myelin Water Imaging ...... 588 Cornelia Laule, Irene M. Vavasour, Shannon H. Kolind, Burkhard Maedler, Anthony L. Traboulsee, Penny Smyth, Alex Rauscher, John Hooge, Virginia Devonshire, Joel Oger, Wayne Moore, David KB Li, Alex L. MacKay,

Whole-Brain Voxel-Wise Analysis of Myelin Water Volume Fraction in Multiple Sclerosis...... 589 Sean CL Deoni

Differentiation of Pathological Processes and Clinical Forms in Multiple Sclerosis: A Tract Based Spatial Statistics Study ...... 590 Salem Hannoun, Francoise Durand-Dubief, Danielle Ibarrola, Jean Christophe Comte, Christian Confavreux, Dominique Sappey- Marinier

Application of Lesion Probability Maps to Predict Progression in Primary-Progressive Multiple Sclerosis: A 10- Year Multi-Centre Study...... 591 Benedetta Bodini, Marco Battaglini, Nicola De Stefano, Zhaleh Khaleeli, Frederik Barkhof, Bruno Brochet, Vincent Dousset, Massimo Filippi, Xavier Montalban, Chris Polman, Marco Rovaris, Alex Rovira, Jaume Sastre-Garriga, David H. Miller, Rebecca Samson, Olga Ciccarelli, Alan J. Thompson

Multimodal NMR Assessment of Erythropoietin as a Neuroprotective Agent Following Hypoxia-Ischemia on P3 Pup Rat Brain ...... 592 Yohan van de Looij, Alexandra Chatagner, Nicolas Kunz, Petra S. Hüppi, Rolf Gruetter, Stéphane V. Sizonenko

Neurochemical Profile of the Mouse Hypothalamus Using 1H MRS at 14.1T...... 593 Hongxia Lei, Carole Poitry-Yamate, Frederic Preitner, Bernard Thorens, Rolf Gruetter

1H MRS of the Visual Cortex Under Chronic Ocular Hypertension...... 594 Kevin C. Chan, Kwok-fai So, Ed X. Wu

Proton MRS Investigation of Human Glioma Models in Nude Mice at 14.1 T...... 595 Vladimir Mlynarik, Cristina Cudalbu, Virginie Clément, Denis Marino, Ivan Radovanovic, Rolf Gruetter

Redox Dependence and Compartmentation of [13C]Pyruvate in the Brain of Deuterated Rats Bearing Implanted C6 Gliomas ...... 596 Tiago Brandao Rodrigues, Pilar Lopez-Larrubia, Sebastián Cerdán

In Situ 3D MR Metabolic Imaging of Microwave-Irradiated Rodent Brain: A New Tool for Metabolomics Research ...... 597 Robin A. de Graaf, Golam MI Chowdhury, Peter B. Brown, Douglas L. Rothman, Kevin L. Behar

Quantification of Brain Glycogen Concentration and Turnover Through Localized 13C NMR of Both the C1 and C6 Resonance ...... 598 Ruud Bernardus van Heeswijk, Florence D. Morgenthaler, Lijing Xin, Rolf Gruetter

17 O T1/T2 Tissue-Relaxation Rates with Anatomical Contrast in the Rat Brain at 16.4 T...... 599 Hannes M. Wiesner, David Z. Balla, Rolf Pohmann, Wei Chen, Kamil Ugurbil, Kamil Uludag

Effect of Short- And Long-Term Type 1 Diabetes on the Neurochemical Profile in STZ-Induced Diabetic Rats at 9.4 T...... 600 Wen-Tung Wang, Sang-Pil Lee, Irina Smirnova, In-Young Choi

Volume 2

Dynamic Metabolic Modeling of [2-13C]Acetate Metabolism in the Rat Brain ...... 601 Alexander A. Shestov, Dinesh K. Deelchand, Pierre-Gilles Henry

Orientationally Invariant Axon-Size and Density Weighted MRI...... 602 Daniel C. Alexander, Penny L. Hubbard, Matt G. Hall, Elizabeth A. Moore, Maurice Ptito, Geoff J. M. Parker, Tim B. Dyrby

How Many Diffusion Gradient Directions Are Required for HARDI? ...... 603 J-Donald Tournier, Fernando Calamante, Alan Connelly

Diffusion Kurtosis Imaging (DKI) Reveals an Early Phenotype (P30) in a Transgenic Rat Model for Huntington’s Disease...... 604 Ines Blockx, Marleen Verhoye, Geert De Groof, Johan Van Audekerke, Kerstin Raber, Dirk Poot, Jan Sijbers, Stephan von Horsten, Annemie Van der Linden

In Vivo Imaging of Kurtosis Tensor Eigenvalues in the Brain at 3 T ...... 605 Eric Edward Sigmund, Mariana Lazar, Jens H. Jensen, Joseph A. Helpern

Detection of Brain Maturation - DTI with Different B-Values Versus Diffusion Kurtosis Imaging ...... 606 Matthew Man Hin Cheung, Ed X. Wu

Super-Resolving Patches in Diffusion MRI Using Canonical Fibre Configurations ...... 607 Simon Jeremy Damion Prince, Daniel C. Alexander

Model-Based Residual Bootstrap of Constrained Spherical Deconvolution for Probabilistic Segmentation and Tractography ...... 608 Hamied Ahmad Haroon, David M. Morris, Karl V. Embleton, Geoff J. Parker

Diffusion Propagator Imaging: A Novel Technique for Reconstructing the Diffusion Propagator from Multiple Shell Acquisitions...... 609 Maxime Descoteaux, Jean-François Mangin, Cyril Poupon

Practical Crossing Fiber Imaging with Combined DTI Datasets and Generalized Reconstruction Algorithm...... 610 Fang-Cheng Yeh, Van Jay Wedeen, Wen-Yih Isaac Tseng

Restriction Spectrum Imaging (RSI): A New Method for Resolving Complex Tissue Microstructures in Diffusion MRI ...... 611 Nathan S. White, Trygve B. Leergaard, Alex de Crespigny, Anders M. Dale

Very Fast Multi Channel B1 Calibration at High Field in the Small Flip Angle Regime ...... 612 Pierre-Francois Van de Moortele, Kamil Ugurbil

Eigenmode Analysis of Transmit Coil Array for SAR-Reduced B1 Mapping and RF Shimming ...... 613 Kay Nehrke, Peter Börnert

Precise and Robust B1+ Characterization of Transmit Coil Arrays...... 614 Martin Janich, Olaf Dössel, Sascha Köhler, Johannes Schneider, Peter Ullmann

Extended Multi-Flip-Angle Approach: A 3D B1unit+ Mapping Method for Inhomogeneous Fields ...... 615 Hans Weber, Dominik Paul, Maxim Zaitsev, Jürgen Hennig, Dominik von Elverfeldt

Targeted B1+ Mapping Using 3D Reduced Field-Of-View Catalyzed Double-Angle Method...... 616 Dingxin Wang, Sven Zuehlsdorff, Reed Omary, Andrew Larson

Actual Flip Angle Imaging: From 3D to 2D ...... 617 Xiaoping Wu, Dinesh Kumar Deelchand, Vasily L. Yarnykh, Kâmil Ugurbil, Pierre-François Van de Moortele

+ Quantitative Comparison of B1 Mapping Methods for 7T Human Imagning ...... 618 Jason E. Moore, Marcin Jankiewicz, Huairen Zeng, Adam W. Anderson, Malcolm J. Avison, E Brian Welch, John C. Gore

Optimization of a Low-Flip-Angle Phase-Based 3D B1 Mapping Technique for High Field Applications ...... 619 Pippa Storey, Graham C. Wiggins, Davide Santoro, Daniel K. Sodickson

A Simple and Fast Flip Angle Calibration Method ...... 620 Sofia Chavez, Greg Stanisz

A Noise Analysis of Flip Angle Mapping Methods ...... 621 Glen Morrell, Matthias Schabel

Accelerating SENSE Using Distributed Compressed Sensing...... 622 Dong Liang, Kevin F. King, Bo Liu, Leslie Ying

Distributed Compressed Sensing for Accelerated MRI ...... 623 Ricardo Otazo, Daniel K. Sodickson

L1 SPIR-iT: Autocalibrating Parallel Imaging Compressed Sensing...... 624 Michael Lustig, Marcus Alley, Shreyas Vasanawala, David L. Donoho, John Mark Pauly

L1-Norm Regularization of Coil Sensitivities in Non-Linear Parallel Imaging Reconstruction...... 625 Carlos Fernández-Granda, Julien Sénégas

SPArse Reconstruction Using a ColLEction of Bases (SPARCLE)...... 626 Ali Bilgin, Onur Guleryuz, Theodore P. Trouard, Maria I. Altbach

Ultra-High Resolution 3D Upper Airway MRI with Compressed Sensing and Parallel Imaging ...... 627 Yoon-Chul Kim, Shrikanth S. Narayanan, Krishna S. Nayak

Highly-Accelerated First-Pass Cardiac Perfusion MRI Using Compressed Sensing and Parallel Imaging ...... 628 Ricardo Otazo, Daniel Kim, Daniel K. Sodickson

Motion Estimated and Compensated Compressive Sensing Dynamic MRI Under Field Inhomogeneity ...... 629 Hong Jung, Jaeseok Park, Jong Chul Ye

Fast Relaxation Parameter Mapping from Undersampled Data ...... 630 Mariya Doneva, Christian Stehning, Peter Börnert, Holger Eggers, Alfred Mertins

Quality Index for Detecting Reconstruction Errors Without Knowing the Signal in L0-Norm Compressed Sensing ...... 631 Carlos A. Sing-Long, Cristian A. Tejos, Pablo Irarrazaval

Parallel Imaging Reconstruction I: Cartesian...... 632 Michael Schacht Hansen

Parallel Imaging Reconstruction II: Non-Cartesian ...... 639 Chunlei Liu

Peripheral Nerve Stimulation in MRI Gradient Coils ...... 642 Blaine A. Chronik

Gradient Coil Design- Safety Aspects ...... 643 Michael A. Morich

BOLD fMRI Signal Interpretation and Calibration ...... 644 Thomas Liu

Mobile Lipid Accumulation as Stress Response...... 646 Edward J. Delikatny

Relaxation and Diffusion Measurements In Vitro, Ex Vivo and In Vivo...... 649 Chantal Rémy, H. Lahrech

Three Decades of MRI and MRS of Bioartificial Liver ...... 651 Jeffrey M. Macdonald

Optical Spectroscopy of Engineered Connective Tissues: Mapping Molecular Components ...... 652 Nancy Pleshko

Liver Function and Failure ...... 655 Bachir Taouli

MRI of Kidney Function and Disease ...... 659 Diego R. Martin

Right Heart Failure: Congenital Heart Disease...... 664 Jean-Paul Vallée

Pulmonary Hypertension...... 665 Gautham Reddy

Arrhythmogenic Right Ventricular Dysplasia and Other Cardiomyopathies ...... 666 Harikrishna Tandri

Techniques for Right Heart Cardiac Function ...... 668 Daniel B. Ennis

Techniques for Diffusion Tensor Imaging in Mouse Brain ...... 671 Jiangyang Zhang

Diffusion Tensor Imaging of Multiple Sclerosis Models ...... 675 Sheng-Kwei Victor Song

Rotator Cuff: MR Findings without Clinical Significance ...... 677 Jenny Bencardino

Clinical Abnormalities that Affect the Rotator Cuff: A Guide for MR Interpretation...... 679 Lynne S. Steinbach

MRI of Rectal Cancer Staging: Evidence and Perspectives ...... 689 Regina G. H. Beets-Tan

Non-Neuro Fetal MRI ...... 690 Ann M. Johnson

GBCAs and NSF: Why Did It Happen and What Have We Learned?...... 691 Jeffrey C. Weinreb

The Fibrocyte's Role in NSF ...... 692 Richard H. Gomer

Consequences Following NSF - Imaging Options in CKD Patients...... 693 Giles H. Roditi

Optimization of Elbow MRI Technique and Normal Anatomy...... 695 James M. Linklater

MRI of the Elbow: Current Concepts...... 704 Russell C. Fritz

Elbow MRI- Case-Based Learning...... 707 Kathryn J. Stevens

8-Channel Eigenmode Tx-Array at 3T for Tx-SENSE ...... 708 Scott B. King, Jarod Matwiy, Mike J. Smith, Ulrich Fontius, Franz Schmitt, Boguslaw Tomanek

Clinical Imaging at 7T with a 16 Channel Whole Body Coil and 32 Receive Channels...... 709 J Thomas Vaughan, Carl Snyder, Lance Delabarre, Jinfeng Tian, Gregor Adriany, Peter Andersen, John Strupp, Kamil Ugurbil

In-Vivo RF Power-Controlled B1 Shimming with Tx/Rx Array and with Tx Array Combined Rx Only Coil Without B1 Measurements...... 710 Tamer S. Ibrahim, Yik-Kiong Hue, Lin Tang, Tiejun Zhao, Fernando E. Boada, Howard J. Aizenstein

7 Tesla Transmit-Receive Array for Carotid Imaging: Simulation and Experiment...... 711 Graham Wiggins, Bei Zhang, Qi Duan, Riccardo Lattanzi, Stephan Biber, Bernd Stoeckel, Kellyanne McGorty, Daniel K. Sodickson

An Eight-Channel Phased Array RF Coil for Spine MR Imaging at 7 Tesla...... 712 Oliver Kraff, Stefan Kruszona, Andreas K. Bitz, Stephan Orzada, Stefan Maderwald, Lena C. Schaefer, Irina Brote, Mark E. Ladd, Harald H. Quick

Vector Iterative Pre-Distortion: An Auto-Calibration Method for Transmit Arrays...... 713 Pascal Pawel Stang, Adam Kerr, William Grissom, John Mark Pauly, Greig Cameron Scott

Variable Power Combiner for a 7T Butler Matrix Coil Array ...... 714 Pedram Yazdanbakhsh, Markus Fester, Ralph Oppelt, Andreas Bitz, Oliver Kraff, Stephan Orzada, Mark E. Ladd, Klaus Solbach

7T Current-Mode Class-D (CMCD) RF Power Amplifier ...... 715 Natalia Gudino, Jeremiah A. Heilman, Matthew J. Riffe, Chris A. Flask, Mark A. Griswold

Frequency Offset Cartesian Feedback Control System for MRI Power Amplifier...... 716 Marta Gaia Zanchi, John Mark Pauly, Greig Cameron Scott

Transmit B1 Field Pattern Control Using RF Current Source Technique...... 717 Wonje Lee, Eddy B. Boskamp, Thomas Grist, Krishna Kurpad

The Biodistribution of [153Gd]Gd-Labeled DTPABMA and DOTA in a Transgenic Mouse Model of Renal Failure Differs Greatly from Wild-Type Mice...... 718 Thaddeus J. Wadas, Christopher D. Sherman, Jeffrey H. Miner, Jeffrey J. Brown, James R. Duncan, Carolyn J. Anderson

Postmortem ICP-MS and MR Analysis of Gadolinium Concentration and Distribution in Three Confirmed NSF Cases...... 719 Peter Caravan, Aashiyana Koreishi, Jonathan Kay

Incidence of Nephrogenic Systemic Fibrosis (NSF) in Dialysis Patients Receiving Either a Standard or a High- Relaxivity Gadolinium Chelate Contrast Agent: A Single Center Study...... 720 Saravanan Kokila Krishnamoorthy, Diego Martin, Khalil Nabeel Salman, Bobby Kalb, John Carew, Philip Andrew Martin, Kenneth Kokko, Christian Larsen, Thomas Pearson

Risk Factors for NSF: A Meta-Analysis...... 721 Honglei Zhang, Giles H. Roditi, Rochelle Morgan, Martin R. Prince

Non-Contrast Enhanced Renal MR Angiography Using NATIVE TrueFISP – Initial Experience for Clinical Imaging of Patients with Renovascular Disease...... 722 Stephen J. Gandy, Prasad Guntur Ramkumar, Shelley A. Waugh, R Stephen Nicholas, Andrew W. Taylor, Xiaoming Bi, Peter Weale, J Graeme Houston

Understanding Renal DTI at 3T: FA and MD Changes with Water Loading ...... 723 Hersh Chandarana, Vivian S. Lee, Irina Barash, Eric E. Sigmund

Kidney Stiffness Measured in an Animal Model of Unilateral Renal Arterial Stenosis Using 2D MR Elastography...... 724 Lizette Warner, Meng Yin, Richard L. Ehman, Lilach Orly Lerman

Effects of Ischemia-Reperfusion Injury on 23Na Relaxation Times and Its Implications on Quantification of Corticomedullary Sodium Concentration by 23Na MRI ...... 725 Bharath Atthe, Andriy Babsky, Navin Bansal

Estimating GFR from Early (Uptake) Portion of DCE MRI Renal Data, Using a 3-Compartment Model, Improves Reproducibility and May Eliminate Need for Cortical Segmentation ...... 726 Paul S. Tofts, Marica Cutajar, Iosif Mendichovszky, Isky Gordon

Edema Control by Anti-VEGF Therapy Prolongs Survival Despite Persistent Tumor Growth in Mice ...... 727 Christian T. Farrar, Walid Kamoun, Carsten D. Ley, Young R. Kim, Guangping Dai, Bruce R. Rosen, Rakesh K. Jain, A. Gregory Sorensen

Noninvasive Therapeutic Evaluation on Rodent Liver Tumor Treated with Vascular Disrupting Agent: Multiparametric Magnetic Resonance Imaging in Correlation with Microangiography and Histology ...... 728 Huaijun Wang, Junjie Li, Feng Chen, Yicheng Ni

Vessel Size Index MRI for Evaluating the Effects of Multiple Anti-Angiogenic Therapies in Sequence...... 729 Sharon E. Ungersma, Glenn Pacheco, Anil Bagri, Shang-Fan Yu, Andrew Mcgeehan, Sarajane Ross, Richard AD Carano

Assessment of Vascular Remodelling During Antiangiogenic Tumor Therapy Using DCE-MRI and Vessel Size Imaging ...... 730 Stefan Zwick, Ralph Strecker, Moritz Palmowski, Peter Gall, Valerij Kiselev, Arne Hengerer, Wolfhard Semmler, Fabian Kiessling

Measurement of the Increase in Vessel Size Induced by a Vascular Disrupting Agent in Orthotopic Prostate Tumours Using Vessel Size Imaging ...... 731 Simon Walker-Samuel, Jessica K. Boult, Lesley D. McPhail, Simon P. Robinson

Can DCE MRI Predict Risk of Treatment Failure in Early-Stage Favorable-Prognosis Cervical Cancer Patients?...... 732 Nina A. Mayr, William T.C. Yuh, Hualin Zhang, Lanchun Lu, Joe F. Montebello, Steffen Sammet, Guang Jia, Jeffrey M. Fowler, Kyle Porter, David Jarjoura, Jian Z. Wang

Combining DCE-MRI and Microbubble Ultrasound to Evaluate Response to Sunitinib in Patients with Renal Cell Carcinoma ...... 733 Colleen Bailey, Ross Williams, Gord Lueck, Mostafa Atri, Peter N. Burns, Greg J. Stanisz, Georg A. Bjarnason

Potential of Choline SNR, Tumor Volume and Diameter in the Assessment of Response of Locally Advanced Breast Cancer Patients Using Sequential MRSI and MRI ...... 734 Karikanni Kalathil A. Danishad, Uma Sharma, Rani Gupta Sah, Vurthaluru Seenu, Rajinder Parshad, Naranamangalam R. Jagannathan

Choline Metabolites as Biomarkers for Predicting Response to Neoadjuvant Chemotherapy in Local Advanced Breast Cancer Patients...... 735 Maria Dung Cao, Beathe Sitter, Tone Frost Bathen, Per E. Lønning, Steinar Lundgren, Ingrid Susann Gribbestad

Noninvasive Detection of Carboxypeptidase G2 Activity in Vivo using 19F 3D CSI...... 736 Yann Jamin, Lynette Smyth, Simon P. Robinson, Thomas R. Eykyn, Caroline J. Springer, Martin O. Leach, Geoffrey S. Payne

Critical Concentration of Contrast Agents for Quantification of Enhancement: Another Reason for Dose Reduction...... 737 Abbas Nasiraei Moghaddam, Reza Habibi, Tariq Balawi, J. Paul Finn

Feasibility of Combined Low-Dose (0.07mmol/kg) Continuous Table Movement MRA of the Peripheral Vessels with Ultra-Low Dose (0.03mmol/kg) TWIST-MRA of the Calf Station ...... 738 Henrik Jakob Michaely, Matthias Voth, Stefan Haneder, Stefan Oswald Schoenberg

SNR Optimized Contrast-Enhanced MRA of the Peripheral Vasculature Using Patient Specific Timing Parameters: Comparison Between High and Conventional Relaxivity Contrast Agents in Patient Suspected of Arterial Occlusive Disease ...... 739 George Rachid de Oliveira, Earl Michael Chester, Gregory Wilson, Jeffrey H. Maki

Effect of Flip Angle Evolution on Flow Sensitivities in ECG-Gated Fast Spin Echo MRA Methods at 3T...... 740 Iliyana P. Atanasova, Pippa Storey, Ruth P. Lim, Jian Xu, Qin Chen, Andrew Laine, Vivian S. Lee

Non Contrast MRA of the Hand in Patients with Raynauds Disease Using Flow Sensitized Dephasing Prepared SSFP...... 741 John J. Sheehan, Zhaoyang Fan, James C. Carr, Debiao Li

Non-Invasive Assessment of Transstenotic Pressure Gradients Utilizing 3D Phase Contrast MRA: Validation Against Endovascular Pressure Measurements in a Porcine Study ...... 742 Thorsten Alexander Bley, Kevin M. Johnson, Oliver Wieben, Christopher J. Francois, Scott B. Reeder, Mark L. Schiebler, Darren P. Lum, Thomas M. Grist

B1 Inhomogeneity in the Thigh at 3T and Implications for Peripheral Vascular Imaging ...... 743 Pippa Storey, Vivian S. Lee, Daniel K. Sodickson, Davide Santoro, Bei Zhang, Ruth P. Lim, Iliyana P. Atanasova, David R. Stoffel, Qun Chen, Graham C. Wiggins

Ungated Ghost MR Angiography ...... 744 Ioannis Koktzoglou, Robert R. Edelman

Non-Contrast-Enhanced Flow-Independent Peripheral Angiography with Magnetization-Prepared IDEAL Balanced-SSFP...... 745 Tolga Çukur, Ann Shimakawa, Huanzhou Yu, Brian A. Hargreaves, Bob S. Hu, Dwight G. Nishimura, Jean H. Brittain

Flow Saturation Inversion Recovery Non-Contrast-Agent MR Angiography for Lower Extremity ...... 746 Mitsuharu Miyoshi, Naoyoki Takei, Tetsuji Tsukamoto

Altered Resting-State Default Mode Network Connectivity in Adults Prenatally Exposed to Alcohol...... 747 Priya Santhanam, Zhihao Li, Mary Ellen Lynch, Claire D. Coles, Xiaoping Hu

Prenatal Cocaine Exposure Alters Ventromedial Prefrontal Activity Associated with Emotion Regulation...... 748 Zhihao Li, Priya Santhanam, Claire D. Coles, Mary Ellen Lynch, Stephan Hamann, Xiaoping Hu

Greater Than Age-Related Decline in Temporal and Occipital Cortices of Methamphetamine Users...... 749 Helenna Nakama, Ryan Shimotsu, Thomas Ernst, George Fein, Linda Chang

Disrupted Midbrain-Thalamus Functional Connectivity in Cocaine Abusers...... 750 Dardo Tomasi, Nora D. Volkow, Ruiliang L. Wang, Jean H. Carrillo, Thomas Maloney, Nelly Alia-Klein, Patricia A. Woicik, Frank Telang, Rita Z. Goldstein

Acute Ethanol Alters GABA and MyoInositol in Human Brain...... 751 Graeme F. Mason, June Watzl, Stuart Weinzimer, Gerard Sanacora, Elizabeth Guidone, Ismene L. Petrakis, Douglas L. Rothman, John H. Krystal

Glutamate Alterations in Alcohol Dependent Patients During Early Detoxification ...... 752 Gabriele Ende, Nuran Tunc-Skarka, Wolfgang Weber-Fahr, Mareen Hoerst, Matthias Ruf, Monika Uhrig, Derik Hermann, Karl Mann

Negative Correlation Between Medial Frontal Activity During Inhibitory Control and Impulsiveness in Abstinent Heroin Dependents: An fMRI Study...... 753 Li-ping Fu, Zhi-tong Zou, Shi-jiang Li, Guo-hua Bi, Yan Wang, En-mao Ye, Lin Ma, Zheng Yang

[1-13C] Acetate MRS to Study Glial Glutamate Dysfunction in Methamphetamine Users ...... 754 Napapon Sailasuta, Kent Harris, Osama Abulseoud, Brian Ross

Brain Reactivity to Smoking-Related Cues During Tobacco Abstinence: An fMRI Study...... 755 Amy C. Janes, Blaise deB Frederick, Sarah Richardt, Caitlin Burbridge, Emilio Merlo-Pich, Perry F. Renshaw, A. Eden Evins, Maurizio Fava, Marc J. Kaufman

Live Brain MRI Detection of Glia Activation by Psychostimulant Exposure ...... 756 Christina H. Liu, Jia Q. Ren, Pradeep G. Bhide, Philip K. Liu

Bio-Functional Magnetic Nanoparticles for MR Monitoring and Localized Hyperthermic Treatment of Cancer...... 757 Panagiotis G. Kyrtatos, Michael R. Loebinger, Anthony N. Price, Mathew Kallumadil, Paul Southern, Quentin A. Pankhurst, Sam M. Janes, Mark F. Lythgoe

Endocavitary Phased Array Applicator of Therapeutic Ultrasound with an Integrated Opposed-Solenoid Coil for High Resolution MRI-Guided Thermotherapy: An in Vivo Study...... 758 Mihaela Rata, Francois Cotton, Christian Paquet, Vlad Birlea, Michael Bock, Rares Salomir

Fast Imaging Sequence for Temperature Monitoring in Moving Objects...... 759 Bruno Madore, Jing Yuan, Chang-Sheng Mei, Lawrence P. Panych

Three Dimensional Motion Compensation for Real-Time MRI Guided Focused Ultrasound Treatment of Abdominal Organs ...... 760 Mario Ries, Baudouin Dennis De Senneville, Gregory Maclair, Max O. Köhler, Bruno Quesson, Chrit Moonen

Advances in Real-Time MR Temperature Mapping of the Human Heart...... 761 Sebastien Roujol, Baudouin Denis de Senneville, Gregory Maclair, Silke Hey, Pierre Jais, Chrit Moonen, Bruno Quesson

Reference-Less MR Thermometry Using Iteratively-Reweighted L1 Regression ...... 762 William Allyn Grissom, Michael Lustig, Viola Rieke, Andrew B. Holbrook, John B. Pauly, Kim B. Butts-Pauly

3-D MR Temperature Imaging with Model Predictive Filtering Reconstruction...... 763 Nick Todd, Allison Payne, Dennis Parker

Transcranial MRI-Guided Focused Ultrasound Surgery of Brain Tumors: Initial Findings in Patients...... 764 Nathan McDannold, Greg Clement, Eyal Zadicario, Peter Black, Ferenc Jolesz, Kullervo Hynynen

Determination of Pulse Sequence and Timing of Contrast-Enhanced MRI for Assessing Blood-Brain Barrier Disruption Following Transcranial Focused Ultrasound...... 765 Jun-Cheng Weng, Sheng-Kai Wu, Feng-Yi Yang, Win-Li Lin, Wen-Yih I. Tseng

PRF Shift in Frozen Tissue at 3T...... 766 Elena Kaye, Aiming Lu, Marcus Alley, Kim Butts Pauly

Experimentally Measured Intracellular Water at Very Short Diffusion Times ...... 767 Kevin D. Harkins, Jean-Phillipe Galons, Joe L. Divijak, Theodore P. Trouard

Permeability and Surface Area of Cell Membranes from the DWI Signal...... 768 Dmitry S. Novikov, Jens H. Jensen, Joseph A. Helpern

Fast Monte Carlo Simulations Replace Analytical Tissue Models in Diffusion MRI...... 769 Markus Nilsson, Erik Alerstam, Sara Brockstedt, Ronnie Wirestam, Freddy Ståhlberg, Jimmy Lätt

MR Characterization of Compartment Shape Anisotropy (CSA)...... 770 Evren Ozarslan

Feasibility of in Vivo Metabolites Diffusion Tensor Assessment...... 771 Nicolas Kunz, Stéphane Sizonenko, Rolf Gruetter

On the Effects of Dephasing Due to Local Gradients in DTI Experiments: Relevance for DTI Fiber Phantoms ...... 772 Frederik Bernd Laun, Sandra Huff, Bram Stieltjes

Comparison of DTI Fiber Tracks with Light Microscopy of Myelinated Fibers...... 773 Ann Sunah Choe, Xin Hong, Daniel Christopher Colvin, Iwona Stepniewska, Zhaohua Ding, Adam W. Anderson

Correlation Between R2 and FA in Human Brain White Matter...... 774 Tie-Qiang Li, Masaki Fukunaga, Peter van Gelderen, Jeff H. Duyn

Evaluation of Within-Site and Cross-Site Accuracy and Precision of DTI Measurements Through a Multi-Center Human Volunteer Study ...... 775 Tong Zhu, Michelle Gaugh, Xiaoxu Liu, Michael Taylor, Yuen Tso, Giovanni Schifitto, Constantin Yiannoutsos, Bradford Navia, Jianhui Zhong

Statistical Assessment of the Effects of Physiological Noise and Artifacts in a Population Analysis of Diffusion Tensor MRI Data...... 776 Lindsay Walker, Lin-Ching Chang, Efstathios Kanterakis, Luke Bloy, Kristina Simonyan, Ragini Verma, Carlo Pierpaoli

Robust Water/Fat Separation in the Presence of Large Field Inhomogeneities Using a Graph Cut Algorithm...... 777 Diego Hernando, Peter Kellman, Justin Haldar, Zhi-Pei Liang

Fast Dynamic Fat-Water Separation Using Shorter Spatial-Spectral Excitation and Novel Temporal Acquisition...... 778 Jing Yuan, Tzu-Cheng Chao, Riad S. Ababneh, Yi Tang, Lawrence P. Panych, Bruno Madore

Magnitude Fitting Following Phase Sensitive Water-Fat Separation to Remove Effects of Phase Errors ...... 779 Huanzhou Yu, Ann Shimakawa, Scott B. Reeder, Charles A. McKenzie, Jean H. Brittain

A Weighted Gradient Regularization Solution to the Inverse Problem from Magnetic Field to Susceptibility Maps (Magnetic Source MRI): Validation and Application to Iron Quantification in the Human Brain ...... 780 Ludovic de Rochefort, Tian Liu, Bryan Kressler, Jian Liu, Pascal Spincemaille, Jianlin Wu, Yi Wang

Susceptibility Mapping in the Human Brain at 3 and 7T ...... 781 Samuel James Wharton, Andreas Schäfer, Richard Bowtell

Improvements in Quantitative Magnetic Susceptibility Mapping at Using Additional Low Resolution Scans ...... 782 Maarten J. Versluis, Matthias J.P. van Osch, Mark A. van Buchem, Andrew G. Webb

Quantitative Susceptibility Mapping of Human Brain by Inverting Local Magnetic Fields Measured at Multiple Small Angles...... 783 Tian Liu, Pascal Spincemaille, Ludovic de Rochefort, Martin Prince, Yi Wang

The Dependence of Tissue Phase Contrast on Orientation Can Be Overcome by Quantitative Susceptibility Mapping...... 784 Karin Shmueli, Peter van Gelderen, Brian Yao, Jacco A. de Zwart, Masaki Fukunaga, Jeff H. Duyn

Removing Background Phase Variations in Susceptibility Weighted Imaging Using a Fast, Forward-Field Calculation ...... 785 Jaladhar Neelavalli, Yu-Chung Norman Cheng, Jing Jiang, Ewart Mark Haacke

Advanced MR Imaging in Perinatal Brain Injury: Timing of Injury-Potential for Intervention ...... 786 Terri E. Inder

Application of Advanced MR Methods for Fetal Imaging: Spectroscopy, Diffusion Tensor Imaging (DTI) and Arterial Spin Labeling ...... 787 Robert V. Mulkern

MRI of the Brain in Moving Subjects ...... 788 Joseph V. Hajnal

Cardiovascular MR in Neonates and Infants ...... 791 Taylor Chung

MRCP in the Neonates...... 792 Myeong-Jin Kim

Magnetic Resonance of the Hip...... 794 Hollis G. Potter

Knee MRI Update: Case Review 2009 ...... 799 Russell C. Fritz

MRI of the Lower Extremity: Ankle and Foot...... 804 James M. Linklater

The Effect of Galactose and Fructose Intake on Synthesis of Liver Glycogen: A 13CMRS Study...... 808 Roy Jentjens, Michael Ith, Eva Scheurer, Jacques Décombaz, Asker Jeukendrup, Chris Boesch

13C MRS Shows Altered Cerebral Glucose Metabolism During Acute Mild Hypoglycemia in Humans ...... 809 Kim van de Ven, Marinette van der Graaf, Bastiaan de Galan, Cees Tack, Arend Heerschap

Effect of Suppression of Free Fatty Acids on ATP Turnover and Inorganic Phosphate Uptake in Type 2 Diabetes Studied by 31P-MRS During an Isoglycaemic-Hyperinsulinaemic Clamp ...... 810 Kieren Grant Hollingsworth, Ee Lin Lim, Mei Jun Chen, Jean Gerrard, Roy Taylor

Endogenous Gluconeogenic Sources Account for the Majority of Hepatic Glycogen Synthesis After an Oral Glucose Load in 24-Hour Fasted Rats ...... 811 Ana Francisca Soares, John Griffith Jones, Francisco Veiga, Rui Albuquerque Carvalho

Localized MRS of Human Pancreas...... 812 Ildiko Lingvay, Angela L. Price, Jaime Legendre, Sarmistha Sen, Lidia S. Szczepaniak

The Effect of Nutritional Early-Life Programming on Adult Body Composition and Appetite Regulation ...... 813 Jelena Anastasovska, Nachiket Abhay Nadkarni, Po-Wah So, Neena Modi, Elizabeth Louise Thomas, Gary Frost, Jimmy D. Bell

Phosphorous and Carbon Spectroscopy of Porcine Islet Extracts : Comparison of Effects of Normoxic and Hypoxic Culture Conditions...... 814 Chardonay Julia Vance, Hitoshi Kubo, Kristen Stewart Maynard, Klearchos K. Papas, Gulin Oz

Liver 31P MRSI Using an 8-Channel Dual-Tuned 31P/1H Coil at 3T...... 815 Anshuman Panda, Judy Rose James, Uwe Boettcher, Rahul Srinivasa Raghavan, Kumar Sandrasegaran, Alex Aisen, Helmut Stark, Navin Bansal, Ulrike Dydak

Toward Quantitation of Pancreatic b Cell Mass Using a Two-Site Exchange Analysis of Manganese-Enhanced MR Images ...... 816 Patrick F. Antkowiak, Moriel H. Vandsburger, Sarah Tersey, Raghavendra G. Mirmira, Frederick H. Epstein

MR-Guided Engraftment of Human Pancreatic Islet Cells in a Diabetic Swine Using Immunoprotection with Clinically Applicable Magnetocapsules...... 817 Dian Respati Arifin, Aravind Arepally, Thomas W. Link, Wesley D. Gilson, Victor A. Ferrari, Robert L. Wilensky, Dara L. Kraitchman, Jeff W.M. Bulte

Cardiac Magnetic Resonance (CMR) Evaluation of Patients with ST-Elevated Acute Myocardial Infarction (STEMI): Influence of Time-To-Reperfusion on the Extent of the Area at Risk, Infarct Size and Microvascular Damage ...... 818 Iacopo Carbone, Marco Francone, Emanuela Algeri, Ilaria Iacucci, David Cannata, Luciano Agati, Carlo Catalano, Roberto Passariello

Quantitative Tissue Characterization of Infarct Heterogeneity in Patients with Ischemic Cardiomyopathy by Magnetic Resonance Predicts Future Cardiovascular Events ...... 819 Harendra Patel, Shahriar Heidary, Hajime Yokota, Chandra Katikireddy, Patricia Nguyen, John M. Pauly, Masahiro Terashima, Michael V. McConnell, Phillip C. Yang

Clinical Validation of Multi-Contrast Delayed Enhancement (MCDE) for Wall Motion and Viability Imaging ...... 820 Jay Stephen Detsky, Kim A. Connelly, Gideon A. Paul, John J. Graham, Alexander J. Dick, Graham A. Wright

Papillary Muscle Infarction by Delayed-Enhancement Magnetic Resonance Imaging: Reproducibility and Potential as an Independent Predictor of Ischemic Mitral Regurgitation...... 821 Thananya Boonyasirinant, Ronan Curtin, Randolph M. Setser, Michael L. Lieber, Scott D. Flamm

Elite Olympic Calibre High-Endurance Athletes Have Evidence for Myocardial Fibrosis : A Cardiovascular Magnetic Resonance Study...... 822 Myra Sabene Cocker, Oliver Strohm, David J. Smith, Craig Butler, Israel Belenkie, Willem Meeuwisse, Matthias G. Friedrich

Cardiac T1 Mapping: A Comparison of Methodologies for Quantifying Cardiac T1 Values...... 823 Ting Song, Maureen N. Hood, Vincent B. Ho, Sandeep N. Gupta, Jeffrey A. Stainsby

Myocardial T2 Mapping Free of Distortion Using Susceptibility Weighted Spin-Echo Based Imaging: A Feasibility Study at 1.5 T and 3.0T...... 824 Uwe Heinrichs, Jane Francis Utting, Tobias Frauenrath, Fabian Hezel, Gabriele A. Krombach, Michael AJ Hodenius, Sebastian Kozerke, Thoralf Niendorf

Navigator-Gated T2 and T2-Weighted Imaging of Myocardial Edema and Hemorrhage Following Primary Coronary Intervention ...... 825 Declan Patrick O'Regan, Rizwan Ahmed, Giuliana Durighel, Amy McGuinness, Jo V. Hajnal, Stuart A. Cook

Navigated DENSE Strain Imaging for Post RF-Ablation Lesion Assessment in Swine Left Atria: A Comparison with Delayed Enhancement ...... 826 Ehud Jeruham Schmidt, Maggie M. Fung, Pelin Aksit, GodtFred Holmvang, Ting Song, Sandeep M. Gupta, Andre D'Avila, Vivek Y. Reddy, Stephan B. Danik

Simultaneous Three-Dimensional Visualisation of Delayed Enhancement and T2 Weighted MRI for the Characterisation of RF Ablation Lesions ...... 827 Benjamin R. Knowles, Dennis Caulfield, Aldo Rivaldi, Michael Cooklin, Jaswinder S. Gill, Julian Bostock, Reza Razavi, Kawal S. Rhode, Tobias Schaeffter

Optimisation of a Balanced Fast Field Echo Cine Sequence for the Assessment of Human Fetal Motor Function ...... 828 Tayyib Hayat, Joanna Allsop, Amy McGuinness, Fabrizio Ferrari, Mary Rutherford, Joseph V. Hajnal

The Evolution of Brain Functional Architecture from the Age of 2 Weeks to 2 Years...... 829 Wei Gao, Hongtu Zhu, Kelly Giovanello, Keith Smith, Dinggang Shen, John Gilmore, Weili Lin

Differences in Blood Perfusion Between Extremely Low Birth Weight (ELBW) Pre-Term Infants and Control Term Infants ...... 830 Arvind Caprihan, U Sakoglu, J Pfeuffer, J Rael, J Stephen, J Lowe, S Duvall, C Gasparovic, R K. Ohls, J P. Phillips

Development of Major White Matter Tracts in Fetal Brains Revealed by DTI...... 831 Hao Huang, Linda J. Richards, Paul Yarowsky, Susumu Mori

Following the Development of Corpus Callosum (CC) in the Prenatal Period in Humans Through Diffusion Tensor Tractography (DTT) ...... 832 Richa Trivedi, Sona Saksena, Shruti Agarwal, Nuzhat Husain, Ram K S Rathore, Rakesh K. Gupta

Quantitative Diffusion Tensor Tractography (DTT) of Motor and Sensory White Matter Pathways in Cerebral Palsy ...... 833 Richa Trivedi, Shruti Agarwal, Vipul Shah, Vimal K. Paliwal, Ram K S Rathore, Rakesh K. Gupta

Early White Matter Maturation: A Longitudinal Study of Normal Pediatric Subjects from the Age of 2 Weeks to 4 Years ...... 834 Yasheng Chen, Hongtu Zhu, Dinggang Shen, Hongyu An, John Gilmore, Weili Lin

White Matter Maturation in Healthy Children and Patients Treated with Brain Radiation: A Longitudinal DTI Study ...... 835 Firouzeh Tannazi, Todd R. McNutt, Siamak Ardekani, Moody D. Wharam, Alena Horska

Voxel Based Analysis of Diffusion Indices and Deformation Based Volumetric Alterations in Late Childhood and Adolescence ...... 836 Siamak Ardekani, Firouzeh Tannazi, Alena Horska

Multimodality Neuroimaging to Study Tourette Syndrome: Correlating AMT-PET and DT-MRI...... 837 Anita SD Saporta, Malek I. Makki, Benjamin J. Wilson, Michael E. Behen, Otto Muzik, Csaba Juhasz, Harry T. Chugani

What Imaging Biomarkers Are and How They Are Used ...... 838 John C. Waterton

Non-Imaging Biomarkers and Regulatory Aspects of Imaging Biomarkers...... 842 Jeffrey L. Evelhoch

Preclinical Applications of Imaging Biomarkers ...... 844 Markus von Kienlin

Imaging Biomarkers in Neurodegenerative Diseases ...... 845 Clifford R. Jack Jr.

What is New in Contrast-Enhanced MRI?...... 847 Marco Essig

Contrast at High Field ...... 853 Michael V. Knopp

The Use of High-Dosage Contrast in the Era of NSF ...... 854 Ruth C. Carlos

The Use of MR Contrast Media in Pregnant Women and Small Children ...... 855 Pia C. Sundgren

Use of Contrast Agents in Functional Imaging Techniques: Perfusion or Dynamic Contrast-Enhanced MRI vs. Non-Enhanced Techniques...... 857 Xavier G. Golay

What to Know to Do It Well...... 860 John L. Ulmer

Case-Based Teaching Course: fMRI and DTI in Clinical Practice -Limitations ...... 861 Andreas Bartsch

MR Physics for Clinicians- Ultrafast Imaging ...... 864 Jeffrey Tsao

Parallel Imaging...... 869 Mark A. Griswold

High Field Imaging...... 872 Klaus Scheffler

Whole-Body Traveling-Wave Imaging at 7 Tesla: Simulations and Early In-Vivo Experience ...... 874 Bei Zhang, Graham Wiggins, Qi Duan, Riccardo Lattanzi, Daniel K. Sodickson

Travelling-Wave MRI: Initial Results of In-Vivo Head Imaging at 7T ...... 875 David Otto Brunner, Jan Paska, Juerg Froehlich, Klaas Paul Pruessmann

Effective Delivery of the Traveling Wave to Distant Locations in the Body at 7T ...... 876 Anna Andreychenko, Dennis W. Klomp, Bob van den Bergen, Bart L. van de Bank, Hugo Kroeze, Jan J.W. Lagendijk, Peter Luijten, Cornelis A.T. van den Berg

An Optically Detunable Coil for Improved Self Gating in Small Animals ...... 877 Matthias Korn, Reiner Umathum, Jessica Schulz, Axel Joachim Krafft, Wolfhard Semmler, Michael Bock

Calcium Titanate Based Ceramic Resonators for High Field Magnetic Resonance...... 878 Kristina Haines, Thomas Neuberger, Michael Lanagan, Elena Semouchkina, Andrew Webb

Beyond Copper: MR Imaging with Carbon Nanotube Receiver Coils ...... 879 Raju Viswanathan, Bradley Goldstein, Kevan Anderson, Michael Bronskill, Ray Baughman, Mei Zhang, Shaoli Fang, Anvar Zakhidov, Ali Aliev

Operational Inkjet-Printed Metal-On-Kapton MRI Receiver Coil...... 880 Dario Mager, Ute Loeffelman, Andreas Peter, Laura Del Tin, Elmar Fischer, Patrick James Smith, Juergen Hennig, Jan Gerrit Korvink

A Mechanically Rotating RF Transceive System and Method for Applications in Magnetic Resonance...... 881 Adnan Trakic, Bing Keong Li, Ewald Weber, Feng Liu, Stephen Wilson, Stuart Crozier

Real-Time Full-Wave Simulations of RF Coils by Fast Integral Equation Methods ...... 882 Shumin Wang, Jacco de Zwart, Jeff Duyn

Improving SNR by Generalizing Noise Matching for Array Coils...... 883 Christian Findeklee

From Two-Photon Microscopy to BOLD-fMRI: Association of an Undershoot of Arteriolar Diameter with the BOLD Post-Stimulus Undershoot...... 884 Anna Devor, Richard Buxton, Peifang Tian, Ivan Teng, Kun Lu, Larry May, Ron Kurz, Anders Dale

Revisit Nonlinearity in Blood-Oxygenation-Level-Dependent Signal ...... 885 Nanyin Zhang, Essa Yacoub, Xiao-Hong Zhu, Kamil Ugurbil, Wei Chen

Neural and Vascular Response Nonlinearity in Human Visual Cortex ...... 886 Zhongming Liu, Cristina Rios, Lin Yang, Nanyin Zhang, Wei Chen, Bin He

Measurement of Parenchymal T2 Changes During Visual Stimulation Using Grey Matter Nulled and VASO fMRI...... 887 Yuji Shen, Ida Mengyi Pu, Risto A. Kauppinen

BOLD Imaging of Inhibition and Facilitation Induced by Paired-Pulse Transcranial Magnetic Stimulation: Feasibility and Reproducibility...... 888 Juergen Baudewig, Carsten Schmidt-Samoa, Peter Dechent

Cerebral Blood Flow (CBF) and Cerebral Blood Volume (CBV) Coupling Differs During Neuronal and Vascular Tasks ...... 889 Manus Joseph Donahue, Robert D. Stevens, Jun Hua, Alan Huang, James J. Pekar, Peter van Zijl

Transcortical BOLD Impulse Response Functions: Implications for Layer-Specific CMRO2 Calculation...... 890 Peter Herman, Basavaraju G. Sanganahalli, Hal Blumenfeld, Fahmeed Hyder

Layer Specific BOLD Activation in Human V1 at 3 Tesla ...... 891 Peter Jan Koopmans, Markus Barth, David Gordon Norris

BOLD fMRI of Forepaw Stimulation at Different Amplitudes in Mice ...... 892 Simone Claudia Bosshard, Christof Baltes, Thomas Mueggler, Markus Rudin

Predicting Human Decisions in a Social Interaction-Scenario Using Real-Time Functional Magnetic Resonance Imaging (Rt-fMRI) ...... 893 Maurice Hollmann, Sebastian Baecke, Charles Mueller, Johannes Bernarding

Development of a Magnetosonoporation-Enhanced Stem Cell Labeling Technique...... 894 Bensheng Qiu, Daohai Xie, Piotr Walczak, Jesus Ruiz-Cabello, Satoshi Minoshima, Jeff W.M. Bulte, Xiaoming Yang

Enhanced Cerebral Targeting of Magnetically Labeled Glial Precursor Cells Using the VLA-4/VCAM-1 Adhesion Pathway ...... 895 Piotr Walczak, Michael Levy, Michael Gorelik, Douglas A. Kerr, Jeff W.M Bulte

Development of an in Vivo Functional Assay to Monitor the Effect of SPIO Labeling on Murine Dendritic Cells Used for Cell Therapy in MRI ...... 896 Richard Tavaré, Gopal Varma, Pervinder Sagoo, Yakup Tanriver, Tobias Schaeffter, Robert Lechler, Giovanna Lombardi, Greg Mullen

Using a 19F MRI Tracer Agent for in Vivo Tracking of Human Dendritic Cell Vaccines...... 897 Brooke M. Helfer, Aaron D. Nelson, Jelena M. Janjic, Eric T. Ahrens, Roberto R. Gil, Pawel Kalinski, Jolanda de Vries, Robbie B. Mailliard

Tracking Enhanced Green Fluorescence Protein (EGFP) and Micrometer-Sized Particles of Iron Oxide (MPIO) Labeled Mesenchymal Stem Cells (MSCs) in a Myocardial Infarction Model with Granulocyte-Colony Stimulating Factor (GCSF) Modulation ...... 898 Yidong Yang, Yuhui Yang, Brianna Klein, Nathan Yanasak, Xingming Shi, William Dave Hill, Tom C.-C. Hu

Ferritin Overexpression for Molecular Imaging of Transplanted Cells ...... 899 Anna Naumova, Hans Reinecke, Vasily Yarnykh, Chun Yuan, Charles Murry

MR-Visible and Immunoprotective Alginate Microcapsules for Treatment of Fulminant Liver Failure ...... 900 Thomas W. Link, Dian Arifin, Chris M. Long, Piotr Walczak, Naser Muja, Jeff W.M Bulte

Facilitated Detection and Quantification of Theragnostic Magnetocapsules by Analyzing MRI Susceptibility Perturbations ...... 901 Parker H. Mills, Thomas Link, Aravind Arepally, Joseph D. Thompson, Jeff W.M. Bulte, Eric T. Ahrens

Novel Trimodal Gadolinium-Gold Microcapsules for Simultaneous Immunoprotection and Positive Contrast MRI, X-Ray, and Ultrasound Imaging of Human Pancreatic Islet Cells ...... 902 Dian Respati Arifin, Christopher Long, Assaf A. Gilad, Sameer Manek, Emma Call, Christophe Alric, Stephane Roux, Olivier Tillement, Thomas W. Link, Aravind Arepally, Jeff W.M. Bulte

Multifunctional Perfluorinated Microcapsules for Mesenchymal Stem Cell Delivery and Engraftment Tracking Using 19F MRI, X-Ray, and Ultrasound ...... 903 Yingli Fu, Dorota A. Kedziorek, Ronald Ouwerkerk, Steven M. Shea, Nicole Azene, Aravind Arepally, Jeff WM Bulte, Robert Krieg, Frank Wacker, Dara L. Kraitchman

Sources of Hepatic Glycogen Synthesis During an Oral Glucose Tolerance Test: Effect of Transaldolase Exchange on Flux Estimates ...... 904 Teresa Cardoso Delgado, Claúdia Silva, Isabel Fernandes, Madalena Caldeira, Margarida Bastos, Carla Baptista, Manuela Carvalheiro, Carlos F.G.C. Geraldes, John Griffith Jones

A Novel 13C MRS-Based Marker of Pyruvate Cycling in Perfused Mouse Liver Using [2-13C] Pyruvate and 13C MRS ...... 905 Corin O'Dell Miller, Haiying Liu, Leslie Balogh, Jin Cao, Mike R. Tota, Reshma Patel

Liver Tissue Repair in a Mouse Model of Toxicant-Induced Liver Injury Is Associated with Increased Hepatic Energy Metabolism: a Multinuclear Magnetic Resonance Study...... 906 Sven Gottschalk, Tom S. Chan, Valérie-Ann Raymond, Dieter Leibfritz, Claudia Zwingmann, Marc Bilodeau

Detection of Altered Hepatic Gluconeogenesis by Nuclear Magnetic Resonance (NMR) and Hyperpolarized 13C Pyruvate...... 907 Matthew E. Merritt, Crystal Harrison, Craig R. Malloy, A Dean Sherry, Shawn C. Burgess

Real Time Assessment of Krebs Cycle Metabolism with Hyperpolarized [2-13C] Pyruvate ...... 908 Damian John Tyler, Marie Allen Schroeder, Helen Jennifer Atherton, Daniel R. Ball, Mark Aaron Cole, Lisa Claire Heather, Julian L. Griffin, Kieran Clarke, George K. Radda

A 13C Isotopomer Model for Accurate NMR Quantification of Substrate Selection and Anaplerosis ...... 909 Wei Li, Fang Bian, Priyanajana Chaudhuri, Xin Yu

Novel Application of Deuterium MRS: In Vivo Monitoring of Glucose Consumption...... 910 Allen Ye, Jeffrey L. Duerk, Chris A. Flask, Gheorghe D. Mateescu

13 Resolution of H3proS and H3proR Deuterations in [2- C]glutamate...... 911 Tiago Brandao Rodrigues, Inês Ribeiro Violante, Sebastián Cerdán

Hyperpolarized 13C Magnetic Resonance Detection of Carboxypeptidase G2 Activity ...... 912 Yann Jamin, Cristina Gabellieri, Lynette Smyth, Steve Reynolds, Simon P. Robinson, Caroline J. Springer, Martin O. Leach, Geoffrey S. Payne, Thomas R. Eykyn

Generation of Hyperpolarized Substrates by Secondary Labelling with [1,1- 13C] Acetic Anhydride ...... 913 David M. Wilson, Ralph E. Hurd, Albert P. Chen, Mark Van Criekinge, Kayvan Keshari, Sarah J. Nelson, Daniel B. Vigneron, John Kurhanewicz

Magnetic Resonance Imaging and Histological Analysis of Beta-Amyloid Plaques in Both Human Alzheimer’s Disease and APP/PS1 Transgenic Mice...... 914 Mark David Meadowcroft, James R. Connor, Michael B. Smith, Qing X. Yang,

Imaging Biophysics of Axonal Transport with MEMRI: Optic Tract Transport Is Altered in Mouse Model of Alzheimer's Disease...... 915 Elaine L. Bearer, Xiaowei Zhang, Octavian Biris, Russell E. Jacobs

Early Impaired Axonal Transport in a Triple Transgenic Mouse Model of Alzheimer’s Disease ...... 916 Jieun Kim, In-Young Choi, Mary L. Michaelis, Sang-Pil Lee

Longitudinal Assessment of Neurodegeneration in a Spinocerebellar Ataxia Type 1 (SCA1) Mouse Model by 1H MRS at 9.4 Tesla: Correlation with Histopathology ...... 917 Gulin Oz, H. Brent Clark, Christopher D. Nelson, Dee M. Koski, Pierre-Gilles Henry, Malgorzata Marjanska, Dinesh K. Deelchand, Harry T. Orr

Assessment of Neurodegeneration Reversal in a Spinocerebellar Ataxia Type 1 (SCA1) Mouse Model by 1H MRS at 9.4 Tesla...... 918 Gulin Oz, H. Brent Clark, Christopher D. Nelson, Dee M. Koski, Manda L. Vollmers, Harry T. Orr

Increased VEGF Expression Correlates with Severely Reduced Cerebral Perfusion in Glutaric Acidemia Type I (GA-1) Mouse Model of Diet Induced Encephalopathy ...... 919 Jelena Lazovic, William J. Zinnanti, Ellen Wolpert, David A. Antonetti, Russell E. Jacobs

Deformation-Based Morphometry in the R6/2 Huntington's Disease Mouse Brain...... 920 Stephen J. Sawiak, Nigel I. Wood, G B. Williams, A J. Morton, T A. Carpenter

Tract Based Spatial Statistics in Mouse Model of Neurodegerative Unverricht-Lundborg (EPM1) Disease ...... 921 Otto Heikki Henrikki Manninen, Kimmo K. Lehtimäki, Teemu Laitinen, Tarja Joensuu, Outi Kopra, Anna-Elina Lehesjoki, Olli Gröhn

In Vivo Brain Phenotypes of the Reeler Mutant Mouse by Using DT-MRI and MEMRI...... 922 Laura-Adela Harsan, Csaba David, Dominik Paul, Susanne Schnell, Jürgen Hennig, Jochen F. Staiger, Dominik von Elverfeldt

Quantitative Analysis of the Post-Contractile BOLD Effect in Human Skeletal Muscle...... 923 Theodore F. Towse, Jill M. Slade, Jeffrey A. Ambrose, Mark C. DeLano, Ronald A. Meyer

Twisting Motion as a Confound to Skeletal Muscle BOLD ...... 924 Andrew D. Davis, Greg D. Wells, Bereket Falk, Michael D. Noseworthy

Development of a Spin Tag Sequence with Spiral Acquisition for Elucidating Shear at the Deep Gastrocnemius Aponeurosis and Other Dynamics of the Musculoskeletal Elements of the Lower Leg...... 925 Gajanan Nagarsekar, John Hodgson, David Shin, Shantanu Sinha

Dependence of the Ratio of Fiber Length Strain to Aponeurosis Strain (Gear Ratio) of the Human Medical Gastrocnemius on Anatomical Position and Loading Conditions ...... 926 David Dongsuk Shin, John A. Hodgson, Gajanan Nagarsekar, V Reggie Edgerton, Shantanu Sinha

Hamstrings and Quadriceps Muscle Displacements During Knee Joint Flexion as Determined by 3D DENSE...... 927 Niccolo Fiorentino, Xiadong Zhong, Michael Rehorn, Fred Epstein, Silvia Blemker

Vibration Imaging for Functional Analysis of Flexor Muscle Compartments...... 928 Yogesh Kannan Mariappan, Kevin J. Glaser, Armando Manduca, Richard L. Ehman

Dynamic 31P MRS of Exercising Human Muscle in a 7T Whole Body System, with STEAM and Semi-LASER Localisation ...... 929 Martin Meyerspeer, Thomas Mandl, Tom Scheenen, Ewald Moser

Dual Gradient Echo MRI Method for the Evaluation of Muscle Microvascular Function...... 930 Otto Alexander Sanchez, Elizabeth Anne Copenhaver, Marti Ann Chance, Michael James Fowler, Jane Kent-Braun, Bruce Murray Damon

23Na-MRI Contrasts for Application in Muscular Sodium Channel Diseases...... 931 Armin Michael Nagel, Marc-André Weber, Christian Matthies, Julien Dinkel, Karin Jurkatt-Rott, Frank Lehmann-Horn, Lothar Rudi Schad

Effects of a 3-Month Training Program on Muscular Lipid Metabolism and Physical Health in Sedentary Non- Insulin-Dependant Diabetes Mellitus Patients ...... 932 Michael Ith, Monika Mattes-Schaub, Roland Kreis, Kim-Anne Lê, Luc Tappy, Jean-Paul Schmid, Emanuel Christ, Chris Boesch

Reconstruction Strategies for MRI with Simultaneous Excitation and Acquisition...... 933 Markus Weiger, Klaas Paul Pruessmann, Franek Hennel k-t PCA: Temporally Constrained k-t BLAST Reconstruction Using Principal Component Analysis ...... 934 Henrik Pedersen, Sebastian Kozerke

Technique for Reconstruction Based on Intensity Order (TRIO) Applied as a Second Stage for Dynamic MRI Reconstruction ...... 935 Leonardo Ramírez, Claudia Prieto, Cristian Tejos, Marcelo Guarini, Pablo Irarrazaval

Accelerating Dynamic MRI Via Spatially Varying Causal Windows ...... 936 Uygar Sümbül, Juan Manuel Santos, John Mark Pauly

Motion Adaptive HYPR: An Algorithm for Dynamic Imaging Applications ...... 937 Lauren Keith, Alexei Samsonov, Orhan Unal, Dana Peters, Charles Mistretta, Julia Velikina

Integration of Higher-Order Dynamic Fields Into MR Image Reconstruction ...... 938 Bertram Jakob Wilm, Christoph Barmet, Matteo Pavan, Peter Boesiger, Klaas Paul Pruessmann

Effects of Discrete and Finite Sampling in PatLoc Imaging...... 939 Gerrit Schultz, Maxim Zaitsev, Jürgen Hennig

Low-Resolution Spectral Cost Function for Field Map Estimation ...... 940 Kristin L. Granlund, Bruce L. Daniel, Brian A. Hargreaves

Rapid Fieldmap Estimation for Cardiac Shimming...... 941 Saurabh Shah, Peter Kellman, Andreas Greiser, Peter J. Weale, Sven Zuehlsdorff, Renate Jerecic

JIGSAW: Joint Inhomogeneity Estimation Via Global Segment Assembly for Water-Fat Separation ...... 942 Yi Lu, Wenmiao Lu, Brian Andrew Hargreaves

Embedded PLACE Correction for Geometric Distortion and N/2 Ghosting in Single-Shot EPI ...... 943 Qing-San Xiang, Frank Q. Ye

Understanding the Origin of Image Intensity Displacement in Spiral-In Versus Spiral-Out Acquisitions...... 944 Kimberly D. Brewer, Chris V. Bowen, Steven D. Beyea

Simple Robust Estimation of Gradient Delays for Spiral MRI...... 945 Ryan Keith Robison, James Grant Pipe

Eliminating Metal Artifact Distortion Using 3D-PLACE...... 946 Michael Nicholas Hoff, Qing-San Xiang

A Method to Remove Nyquist Ghosts from Echo Planar Images (EPI) Using UNFOLD...... 947 W Scott Hoge, Huan Tan, Robert A. Kraft

B1 Correction Using Dual Tau Look-Locker (D τ LL) ...... 948 Trevor Wade, Brian Rutt

Sense Shimming (SSH), First In-Vivo Results...... 949 Daniel Nicolas Splitthoff, Maxim Zaitsev

Simultaneous Fat Suppression and Band Reduction with Large-Angle Multiple-Acquisition bSSFP...... 950 Neal Kepler Bangerter, Garry E. Gold , Glen R. Morrell, Brian Andrew Hargreaves

Oscillating Radial Trajectories for Reduced Undersampling Artifacts ...... 951 Rizwan Ahmad, Lee C. Potter, Periannan Kuppusamy

Effects of Concomitant Fields on Short-Time-Scale Noble Gas Diffusion Measurements...... 952 Michael Carl, John P. Mugler III, Gordon D. Cates, Wilson Miller

Compressed Sensing and HYPR...... 953 Oliver Wieben

Imaging Reconstruction: Exploiting Spatiotemporal Correlations for Dynamic Imaging...... 957 Jeffrey Tsao

MR Critical Implants, MR Critical Medical Devices and ASTM MR Safety Standards...... 962 Wolfgang Kainz

The New ISO/IEC Standard for Active Implants...... 966 Hans M. L. Engels

Recent Progress on Image Registration and its Applications...... 970 Daniel Rueckert

CANCER: Brain and Other: Animal Studies ...... 972 Risto A. Kauppinen

Cancer: Brain and Other. Clinical Studies...... 977 Martin O. Leach

Urinary Bladder: Imaging the Regeneration of a Dynamic Organ ...... 981 Hai-Ling Margaret Cheng

Cartilage Development in an MRI-Compatible Hollow-Fiber Bioreactor...... 984 Richard G. S. Spencer

Monitoring Tissue Engineering Using Magnetic Resonance Imaging...... 985 Richard L. Magin

Coronary Arteries: What You Need to Know...... 986 Tim Leiner

Heart Failure: What You Need to Know ...... 999 Bernd J. Wintersperger

Myocardial Perfusion Scintigraphy: Advancing from SPECT to PET Imaging ...... 1001 Thomas Schindler

Evaluation of Ischemia/Perfusion Reserve ...... 1002 Michael Jerosch-Herold

Prediction of Functional Recovery (Viability and Perfusion) ...... 1005 Christopher M. Kramer

How to Image CBF in the Mouse Brain...... 1006 Frank Kober

Functional Magnetic Resonance Imaging of the Mouse...... 1010 Kai-Hsiang Chuang

Wrist Instability: MR Findings without Clinical Significance ...... 1013 Hiroshi Yoshioka

Unsolved Problems in MSK MR: Clinical Wrist Abnormalities Not Detectable on MR Imaging ...... 1018 Kimberly K. Amrami

MR Guided Non-Vascular Interventions...... 1021 Jonathan S. Lewin

MR Guided Vascular Interventions ...... 1024 Deniz Bilecen

MR-PET, the Potential for Combined Imaging Modalities...... 1025 Simon R. Cherry

MR-HIFU: The Potential for Combined Imaging and Therapy...... 1026 Kullervo Hynynen

Fat Suppression with Independent Shims for Bilateral Breast MRI...... 1027 Misung Han, Sandra Rodriguez, Anne M. Sawyer, Bruce L. Daniel, Charles Cunningham, John M. Pauly, Brian A. Hargreaves

Preoperative Breast MRI in Patients with Invasive Lobular Carcinoma Reduces the Rate of Surgical Re-Excision...... 1028 Ritse Maarten Mann, Claudette E. Loo, Jelle O. Barentsz, Kenneth G.A. Gilhuijs, Theo Wobbes, Carla Boetes

MRI Characterization of Ex Vivo Healthy Human Lymph Nodes at 7T...... 1029 Mies Andrea Korteweg, Jaco J.M. Zwanenburg, Paul van Diest, I. H. Borel Rinkes, Willem P. Mali, Peter R. Luijten, Wouter B. Veldhuis

Quantitative DWI for Differentiation of Benign and Malignant Breast Lesions: The Influence of the Choice of B- Values...... 1030 Nicky HGM Peters, Koen L. Vincken, Maurice A.A.J. van den Bosch, Peter R. Luijten, Willem Mali, Lambertum W. Bartels

Comparison of Different Diffusion Parameters in DWI for Differentiation of Breast Lesions at 3.0 Tesla – Effects of Perfusion and Diffusion Compartments on ADC...... 1031 Wolfgang Bogner, Stephan Gruber, Katja Pinker, Günther Grabner, Andreas Stadlbauer, Ewald Moser, Thomas Helbich, Siegfried Trattnig

Statistical Modeling of Longitudinal Total Choline Measurements During Chemotherapy...... 1032 Ann M. Brearley, Lynn E. Eberly, Naomi R. Mraz, Michael T. Nelson, Douglas Yee, Michael Garwood, Patrick J. Bolan

The Association Between Choline Concentration Measured by 1H MR Spectroscopy with Clinical Characteristics and Biomarkers of Breast Cancer ...... 1033 Hui Liu, Jeon-Hor Chen, Hyeon-Man Baek, Ke Nie, Hon J. Yu, Orhan Nalcioglu, Min-Ying Lydia Su

Diagnostic Value of Breast Proton Magnetic Resonance Spectroscopy at 1.5T in Different Histological Types ...... 1034 Hyeon-Man Baek, Jeon-Hor Chen, Orhan Nalcioglu, Min-Ying Su

Dynamic Imaging of Dual Contrast-Enhancement Using a Combined MR-Optical Imaging System...... 1035 Mehmet Burcin Unlu, Yuting Lin, Orhan Nalcioglu, Gultekin Gulsen

Image-Guided Combined SiRNA and Enzyme/Prodrug Cancer Therapy...... 1036 Cong Li, Marie-France Penet, Flonné Wildes, Tomoyo Takagi, Paul Winnard Jr. , Dmitri Artemov, Zaver M. Bhujwalla

Evaluation of a Clinical PET/MR System...... 1037 Hans F. Wehrl, Armin Kolb, Martin S. Judenhofer, Matthias P. Lichy, Claus D. Claussen, Bernd J. Pichler

First Hybrid Images from a Combined PET and Field-Cycled MRI System...... 1038 Geron Andre Bindseil, William B. Handler, Timothy J. Scholl, Kyle M. Gilbert, Blaine A. Chronik

Simultaneous MRI/PET Image Acquisition from an MRI Compatible Positron Emission Tomography System...... 1039 Sri Harsha Maramraju, Bosky Ravindranath, Sachin Junnarkar, Dardo Tomasi, S. David Smith, Sudeepti Southekal, Sean Stoll, Sergio Rescia, Jean-Francois Pratte, Martin Purschke, Xiaole Hong, David Bennett, Ken Cheng, Aiping Jiang, William Lenz, Srilalan Krishnamoorthy, Craig Woody, Paul Vaska, David Schlyer

Is Accurate Bone Segmentation Required for MR-Based PET Attenuation Correction? ...... 1040 Ciprian Catana, Andre van der Kouwe, Thomas Benner, Michael Hamm, Christian Michel, Bruce Fischl, Matthias Schmand, Bruce R. Rosen, A. Gregory Sorensen

System for MRI Guided Radiotherapy...... 1041 Johan Overweg, Bas Raaymakers, Jan Lagendijk, Kevin Brown

The Application of MRI Pulse Sequences in the Verification of Proton Beam Radiotherapy ...... 1042 Joao Seco, Ravi Teja Seethamraju, George Phil Broussard, Hanne Kooy, Mukesh Harisinghani

Lorentz Force Effects in Multimodality MR-SPECT Imaging ...... 1043 Mark Jason Hamamura, Seung-Hoon Ha, Werner W. Roeck, Orhan Nalcioglu, Douglas J. Wagenaar, Dirk Meier, Bradley E. Patt

Direct Imaging of SPIOs in Mice Using Magnetic Particle Imaging: Instrument Construction and 3D Imaging...... 1044 Patrick Goodwill, Greig Scott, Pascal Stang, Gary Chiray Lee, Doug Morris, Steve Conolly

A Novel Single-Sided Imaging Device for MR Elastography ...... 1045 Daniel V. Litwiller, Eric A. Borisch, Roger C. Grimm, Joel P. Felmlee, Richard L. Ehman

Development of Cryogen-Free Ultra-Low Field MRI Instrument...... 1046 Byeong Ho Eom, Konstantin Penanen, Peter K. Day, Inseob Hahn, Mark S. Cohen

High-Resolution 3D Coronary Vessel Wall Imaging Using Spiral Image Acquisition at 3T...... 1047 Miriam Wilhelmina Lagemaat, Markus Henningsson, Matthias Stuber, Andrea J. Wiethoff, Rene M. Botnar

Increasing Lipid Core Size in Carotid Plaque Is Predictive of Cardiovascular Events in Elder Asymptomatic Individuals Using Contrast-Enhanced High-Resolution MRI ...... 1048 Jianming Cai, Qingjun Wang, Lin Ma, Youquan Cai, Qian Zhao

Quantification of Arterial Wall Inflammation in Patients with Arteriits Using High Resolution DCE-MRI: A Correlation Study with 18F-FDG PET-CT ...... 1049 Clemens C. Cyran, Tobias Saam, Steven Soubron, José G. Raya, Katja Bochmann, Markus Hacker, Axel Rominger, Peter Bartenstein, Thomas Pfefferkorn, Michael Dichgans, Maximilian F. Reiser, Konstantin Nikolaou

Minimization of MR Contrast Weightings for the Comprehensive Evaluation of Carotid Atherosclerotic Disease...... 1050 Xihai Zhao, Jianming Cai, Hunter Underhill, Minako Oikawa, Li Dong, Hideki Ota, Thomas Hatsukami, Chun Yuan

Multi-Spectral MRI Shows Unorganized Thrombus One Year After Endovascular Abdominal Aortic Aneurysm Repair...... 1051 Sandra Adriana Cornelissen, Maarten J. van der Laan, Koen L. Vincken, Frans L. Moll, Willem P. Mali, Max A. Viergever, Lambertus W. Bartels

Thrombus Development and Fragmentation in Rats Using Non-Enhanced MRI...... 1052 Abdel Bidar, Frank Risse, Anna Ravnefjord, Susanna Pehrsson, Arno Nauerth, Margareta Elg, Paul D. Hockings

Comparison Between Three T1-Weighted Sequences for Detection and Area Measurement of Intraplaque Hemorrhage in Carotid Atherosclerotic Plaque Imaging at 3 Tesla ...... 1053 Hideki Ota, Vasily L. Yarnykh, Marina S. Ferguson, Hunter R. Underhill, J Kevin DeMarco, Minako Oikawa, Li Dong, Xihai Zhao, David C. Zhu, Thomas S. Hatsukami, Chun Yuan

An Optimized 3D Spoiled Gradient for Hemorrhage Assessment Using Inversion Recovery and Multiple Echoes (3D SHINE) for Carotid Plaque Imaging ...... 1054 David C. Zhu, Hideki Ota, Anthony T. Vu, J. Kevin DeMarco

Black Blood Vessel Wall Imaging of the Lower Extremities with T2prep Inversion Recovery: A Feasibility Study...... 1055 Thanh D. Nguyen, Ryan Brown, Matthew D. Cham, Pascal Spincemaille, Priscilla A. Winchester, Grace Choi, Martin R. Prince, Yi Wang

Imaging the Vessel Wall in Major Peripheral Arteries Using Susceptibility Weighted Imaging: Visualizing Calcifications...... 1056 Qi Yang, Jiangtao Liu, Samuel Barnes, Zhen Wu, Kuncheng Li, Jaladhar Neelavalli, Jiani Hu, E. M. Haacke

Non-Invasive, Whole-Brain CMRO2 Mapping of the Human Brain...... 1057 Ian C. Atkinson, Keith R. Thulborn

13 Performance of Hyperpolarized 1,4- C2 Fumarate in a Murine Lymphoma Model in Vivo, a New Diagnostic Agent for Oncology...... 1058 Pernille Rose Jensen, Rene in 't Zandt, Magnus Karlsson, Anna Gisselsson, Georg Hansson, Mathilde Hauge Lerche

Dual Resolution Simultaneous 19F/1H In Vivo Imaging of Targeted Nanoparticles ...... 1059 Jürgen Rahmer, Jochen Keupp, Shelton D. Caruthers, Oliver Lips, Todd A. Williams, Samuel A. Wickline, Gregory M. Lanza

Sodium and Proton Diffusion MRI of Rodent Glioma Therapy at 21 T...... 1060 Victor D. Schepkin, Cathy W. Levenson, Silvia M. Figueiroa, William W. Brey, Peter L. Gor'kov, Kiran K. Shetty

Noninvasive Monitoring of CCl4 Induced Acute and Chronic Liver Damage in Rat by SQ and TQF 23Na MRI ...... 1061 Yong Gao, Judy James, Navin Bansal

Sodium MR Imaging at 3T Using an 8-Channel 23Na and 2-Channel 1H Rx/Tx Coil: Optimization and RF Inhomogeneity Corrections ...... 1062 Judy Rose James, Chen Lin, Ulrike Dydak, Andriy M. Babsky, Helmut Stark, Brian M. Dale, Navin Bansal

Dynamic MRSI for Hyperpolarized [1-13C]-Pyruvate with Multiband Pulses Applied in the TRAMP Prostate Cancer Mouse Model ...... 1063 Peder E. Z. Larson, Robert Bok, Adam B. Kerr, Albert P. Chen, Simon Hu, Matthew L. Zierhut, Michael Lustig, John M. Pauly, Sarah J. Nelson, John Kurhanewicz, Daniel B. Vigneron

In-Vivo Ultra-Fast Spectroscopic Imaging of 19F Containing Contrast Agents ...... 1064 Rolf Lamerichs, Caren van Kammen, Muhammed Yildirim, Klaas Nicolay

Spin-Lock Sodium MRI of the Human Brain: a Preliminary Study...... 1065 David Thomas Pilkinton, Mark A. Elliott, Jeremy F. Magland, Ravinder Reddy

Faster Sodium MRI Through TPI-SENSE: Results at 7T...... 1066 Yongxian Qian, Graham Wiggins, Lawrence L. Wald, Fernando E. Boada

Velocity Selective Inversion Pulse Trains for Velocity Selective Arterial Spin Labeling...... 1067 Eric Wong, Jia Guo

Labeling Efficiency Is Critical in Pseudo-Continuous ASL...... 1068 Sina Aslan, Feng Xu, Peiying L. Wang, Jinsoo Uh, Uma Yezhuvath, Matthias van Osch, Hanzhang Lu

Multi-Phase Pseudo-Continuous Arterial Spin Labeling (MP PCASL): Robust PCASL Method for CBF Quantification ...... 1069 Youngkyoo Jung, Eric C. Wong, Thomas T. Liu

Evaluation of New ASL 3D GRASE Sequences Using Parallel Imaging, Segmented and Interleaved K-Space at 3T with 12- And 32-Channel Coils ...... 1070 David Feinberg, Sudhir Ramanna, Matthias Gunther

QUIPSS II with Window-Sliding Saturation Sequence (Q2WISSE)...... 1071 Ruitian Song, Ralf B. Loeffler, Claudia M. Hillenbrand

ASL Perfusion Measurement Using a Rapid, Low Resolution Arterial Transit Time Prescan ...... 1072 Weiying Dai, Philip M. Robson, Ajit Shankaranarayanan, David C. Alsop

White Matter Cerebrovascular Reactivity Measured with Pseudo-Continuous Arterial Spin Labeling at 3T ...... 1073 Reinoud Pieter Harmen Bokkers, M J P van Osch, Willem P. Mali, Jeroen Hendrikse

Multicenter Reproducibility of Continuous, Pulsed and Pseudo-Continuous Arterial Spin Labeling; Can We Use General Reference Values of Cerebral Blood Flow? ...... 1074 Sanna Gevers, Matthias J.P. van Osch, Jeroen Hendrikse, Reinoud P.H. Bokkers, Dennis A. Kies, Wouter M. Teeuwisse, C.B. Majoie, Aart J. Nederveen

Absolute Cerebral Blood Volume (CBV) Quantification Without Contrast Agents Using Inflow Vascular-Space- Occupancy (IVASO) with Dynamic Subtraction ...... 1075 Manus Joseph Donahue, Bradley J. MacIntosh, Ediri Sideso, Molly Bright, James Kennedy, Ashok Handa, Peter Jezzard

QUantitative Imaging of EXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Velocity Selective Spin Labeling ...... 1076 Divya S. Bolar, Bruce R. Rosen, A Gregory Sorensen, Elfar Adalsteinsson

Feasibility of Evaluating the Spinal Cord with MR Elastography ...... 1077 Scott A. Kruse, Arunark Kolipaka, Armando Manduca, Richard L. Ehman

Structural and Hemodynamic Mouse Spinal Cord Maturation Assessed by High Resolution Diffusion Tensor Imaging (DTI) and Arterial Spin Labeling (ASL)...... 1078 Virginie Callot, Guillaume Duhamel, Patrick J. Cozzone

Quantitative Evaluation of Diffusion Tensor Imaging at 3T in the Cervical Spinal Cord of Patients with Adrenomyeloneuropathy ...... 1079 Aliya Gifford, Seth A. Smith, Ali Fatemi, SakkuBai Naidu, Peter C. van Zijl, Gerald V. Raymond

High-Resolution in Vivo MR Imaging of the Human Spinal Cord at 7 Tesla ...... 1080 Kyongtae Ty Bae, Chan-Hong Moon, Jung-Hwan Kim, Sung-Hong Park

Diffusion-Weighted Imaging of the Spine with Readout-Segmented (RS)-EPI ...... 1081 Samantha J. Holdsworth, Roland Bammer, Stefan Skare

Effect of VEGF Treatment on the Blood-Spinal Cord Barrier Permeability in Experimental Spinal Cord Injury: Dynamic Contrast-Enhanced Magnetic Resonance Imaging ...... 1082 Chirag B. Patel, David M. Cohen, Pallavi Ahobila-Vajjula, Laura M. Sundberg, Tessy Chacko, Ponnada A. Narayana

Radial Fractional Anisotropy Mean and Angular Fractional Anisotropy Mean: New Tools in the Diagnosis and Assessment of Spinal Cord ...... 1083 Arturo Cárdenas-Blanco, Harrison Westwick, Kareem Andre Moran, Eve Chung Tsai

In Vivo Diffusion Tensor Imaging in Rat Model of Chronic Spinal Cord Compression ...... 1084 Matthew Man Hin Cheung, Darrell T.H. Li, Edward S. Hui, Abby Y. Ding, Yong Hu, Ed X. Wu

In Vivo MRS Monitor Delayed Neurodegeneration in Experimental Spinal Cord Injury...... 1085 Junchao Qian, Juan Herrera, Ponnada Narayana

Evaluation of Q-Ball Metrics for Assessing the Integrity of the Injured Spinal Cord ...... 1086 Julien Cohen-Adad, Hugues Leblond, Aurobrata Ghosh, Maxime Descoteaux, Rachid Deriche, Habib Benali, Serge Rossignol

White Matter Is Diffusely Affected in Autism...... 1087 Andrew L. Alexander, Jee Eun Lee, Erin D. Bigler, Molly B. DuBray, Alyson Froehlich, Nicholas Lange, Thomas P. Fletcher, Moo K. Chung, Janet E. Lainhart

The Limbic System in Asperger Syndrome: A Preliminary Diffusion Tensor Imaging Tractography Study ...... 1088 Luca Pugliese, Michel Thiebaut de Scotten, Stephanie Ameis, Flavio Dell'Acqua, Eileen Daly, Declan Murphy, Marco Catani

3T Diffusion Tensor Imaging of Mild Traumatic Brain Injury: A Prospective Longitudinal Study ...... 1089 Joshua Ng, Michael Wahl, Elizabeth Tong, Hana Lee, Srivathsa Veeraraghavan, Duan Xu, Shoujun Zhao, John Kornak, Michele Meeker, Jamshid Ghajar, Geoffrey T. Manley, Pratik Mukherjee

Mapping Traumatic Axonal Injury Using Diffusion Tensor Imaging: Correlations with Functional Outcome ...... 1090 Virginia FJ Newcombe, Doris A. Chatfield, Martin R. Coleman, Joanne G. Outtrim, Sarah Vowler, Anne Manktelow, Justin Cross, Sally G. Harding, Peter JA Hutchinson, Jonathan P. Coles, T.Adrian Carpenter, John D. Pickard, Guy B. Williams, David K. Menon

Optic Radiation Abnormalities After Optic Neuritis ...... 1091 Scott Cameron Kolbe, Clare Bajraszewski, Caron Chapman, Thanh Nguyen, Leigh Johnston, Peter Mitchell, Mark Paine, Helmut Butzkueven, Trevor Kilpatrick, Gary Egan

Multimodality Study for Restless Legs Syndrome: Morphological Changes in White and Gray Matter...... 1092 Byeong-Yeul Lee, Don Bigler, James R. Connor, Qing X. Yang

Diffusion Tensor Imaging of Remaining Brain After Long Term Hemispherectomy...... 1093 Andreia Vasconcellos Faria, Julia Choi, Eileen Patti Vining, Jiangyang Zhang, Kenishi Oishi, Xin Li, Hangyi Jiang, Kazi Akhter, Peter van Zijl, Michael I. Miller, Amy Bastian, Susumu Mori

In Vivo Definition of Parieto-Motor Pathways During Movement Planning Using Twin-Coil TMS and DT-MRI Based Tractography ...... 1094 Mara Cercignani, Giacomo Koch, Carlo Caltagirone, Marco Bozzali

Connective Fiber Tracts in Default Mode Network Mapped by Resting State fMRI and Diffusion Spectrum Imaging ...... 1095 Su-Chun Huang, Fang-Chen Yeh, Wei-Tang Chang, Fa-Hsuan Lin, Wen-Yih Isaac Tseng

Topographic Organization of SMA Connections as Assessed by MR DTI Tractography and Intraoperative Subcortical Mapping...... 1096 Antonella Castellano, Lorenzo Bello, Paola Scifo, Enrica Fava, Giorgio Carrabba, Giulio Bertani, Giuseppe Scotti, Andrea Falini

Left Ventricular Wall Motion Abnormalities: Using Center Point Trajectory (CPT) Mapping to Quantify Focal Lesions ...... 1097 Ting Song, Jeffrey A. Stainsby, Maureen N. Hood, Vincent B. Ho

A Novel Method for Cine-CMR Automated Assessment of Left Ventricular Diastolic Dysfunction ...... 1098 Keigo Kawaji, Noel Christopher Codella, Christopher W. Chu, Richard B. Devereux, Martin R. Prince, Yi Wang, Jonathan W. Weinsaft

Exploring Effective Connectivity During Unilateral Movement in Stroke Using Structural Equation Modeling...... 1099 Wan-wa Wong, Kai-yu Tong, Fei Meng, Kwok-wing Tang, Xiaorong Gao, Shangkai Gao, Suk-tak Chan

Automated Computational Analysis of Neonatal Hypoxic Injury and Implanted Therapeutic Neuronal Stem Cells...... 1100 Nirmalya Ghosh, Stephen Ashwal, Andre Obenaus

Robust Myelin Water Quantification Using Spatially Regularized Nonnegative Least Square Algorithm ...... 1101 Dosik Hwang, Yiping P. Du

Three-Dimensional Segmentation and Visualization of Cerebral Arteries and Veins from Simultaneously Acquired MRA and MRV Based on Graph-Cuts and Vessel Enhancement Filter ...... 1102 Hackjoon Shim, Sung-Hong Park, Kyongtae Ty Bae

Fuzzy Clustering-Based Segmentation of Manganese-Enhanced Neuronal Network Areas on MR Images ...... 1103 Mark J.R.J. Bouts, Jet P. van der Zijden, Wim M. Otte, Rick M. Dijkhuizen

Reduction of Motion Artefacts in Renal Perfusion DCE-MRI Data ...... 1104 Gernot Reishofer, Robert Merwa, Manuela Aschauer, Sabine Zitta, Rudolf Stollberger, Franz Ebner

Quantifying the Vascular Profile of a Tumor by 3D Euclidean Distance Maps ...... 1106 Meiyappan Solaiyappan, Deepak Dinakaran, Yoshinori Kato, Dmitri Artemov

Normal Aging of the Brain ...... 1107 Marco Essig

Pathological Aging of the Brain ...... 1112 Clifford R. Jack Jr.

Cerebral Small Vessel Disease ...... 1115 Mark A. Van Buchem

Psychiatric Diseases...... 1117 Anand Kumar

Changes of Small Bowel Peristalsis in Patients with Crohns Disease...... 1118 Michael A. Patak, Christian Waldherr, Christophoros Stoupis, Sukru Mehmet Erturk, John M. Froehlich

Evaluation of Diffusion-Weighted MR Imaging for Detection of Bowel Inflammation in Patients with Crohn`s Disease: A Pilot Study ...... 1119 Aytekin Oto, Fang Zhu, Kirti Kulkarni, Masatoshi Hori, Arda Kayhan, Gregory S. Karczmar, Jerrold R. Turner, David Rubin

Magnetic Resonance Imaging for the Assessment of Gastro-Esophageal Junction...... 1120 Jelena Curcic, Reto Treier, Elad Kaufman, Zsofia Forras-Kaufman, Mark Fox, Werner Schwizer, Michael Fried, Peter Boesiger

Development and Positive Contrast Imaging of an MR-Visible Mesh-Implant for Repair of Abdominal Hernia...... 1121 Nils A. Kraemer, Jens Otto, Michael Hodenius, Ioana Slabu, Martin Baumann, Uwe Klinge, Andreas Muellen, Boris Obolenski, Rolf W. Guenther, Gabriele A. Krombach

Functional Monitoring of Small Bowel Motility: Comparison of Spasmolysis Induced by Glucagon or Buscopan...... 1122 John M. Froehlich, Muriel Daenzer, Constantin von Weymarn, Sukru Mehmet Erturk, Christoph L. Zollikofer, Michael A. Patak

DTI of the Kidney at 3T - Protocol Evaluation, Reproducibility and Comparison to 1.5T...... 1123 Mike Notohamiprodjo, Annie Horng, Ulrike Attenberger, Olaf Dietrich, Henrik J. Michaely, Karin A. Herrmann, Maximilian F. Reiser, Christian Glaser

Diffusion-Weighted Imaging for the Diagnosis of Bland Versus Tumor Thrombosis in the Portal and Renal Veins...... 1124 Jignesh M. Patel, Elizabeth M. Hecht, Danny C. Kim, James S. Babb, Bachir Taouli, Ruth P. Lim

Differentiation of Pancreas Carcinoma from Healthy Pancreatic Tissue Using a Wide Range of B-Values: Comparison of ADC and IVIM Parameters...... 1125 Andreas Lemke, Lothar Rudi Schad, Frederik Laun, Bram Stieltjes

Longitudinal Assessment of Renal Fibrosis by Diffusion Weighted MRI: A Study in Unilateral Ureteral Obstruction (UUO) Mice Model ...... 1126 Osamu Togao, Shigehiro Doi, Makoto Kuro-o, Masaya Takahashi

Diffusion Tensor Imaging of Renal Ischemia/Reperfusion Injury ...... 1127 Jerry S. Cheung, Shu Juan Fan, April M. Chow, Ed X. Wu

Quantification of the Healthy Human Uncinate Fasciculus Across the Lifespan Using Diffusion Tensor Tractography ...... 1128 Khader M. Hasan, Arash Kamali, Amal Iftikhar, Larry A. Kramer, Paul T. Cirino, Andrew C. Papnicolaou, Jack M. Fletcher, Linda Ewing-Cobbs

Diffusion Tensor Tractography of Corpus Callosum Development Across the Lifespan...... 1129 Saul Caverhill-Godkewitsch, Catherine Lebel, Christian Beaulieu

Age and Gender Related Changes in DTI Metrics in Deep Grey Matter of Normal Human Brain...... 1130 Deepa Pal, Abhishek Yadav, Ram K S Rathore, Chandra Mohan Pandey, Manoj Kumar, Richa Trivedi, Rakesh K. Gupta

Atlas-Based Analysis of Neurodevelopment from Infancy to Adulthood Using Diffusion Tensor Imaging ...... 1131 Andreia Vasconcellos Faria, Jiangyang Zhang, Kenishi Oishi, Xin Li, Hangyi Jiang, Kazi Akhter, Koji Sakai, Laurent Hermoye, Seung-Koo Lee, Michael I. Miller, Peter van Zijl, Susumu Mori

Relationship Between Brain R2 and Liver and Serum Iron Concentrations in Elderly Men ...... 1132 Michael John House, Timothy St. Pierre, John Olynyk, Elizabeth Milward, David Bruce

In Vivo Estimates of Regional Iron Deposition in Young and Elderly Human Brains ...... 1133 Adolf Pfefferbaum, Elfar Adalsteinsson, Torsten Rohlfing, Edith Sullivan

Increased Metabolic Stress with Aging...... 1134 Feng Xu, Andrew Hebrank, Uma Yezhuvath, Daren Denniston, Sherwood Brown, Denise C. Park, Hanzhang Lu

Differential Patterns of Age-Related Changes in Cerebral Blood Flow and Cerebrovascular Reactivity Across the Lifespan ...... 1135 Hanzhang Lu, Yamei Cheng, Andrew Hebrank, Blair Flicker, Uma S. Yezhuvath, Karen Rodrigue, Kristen Kennedy, Denise C. Park

Bolus-Tracking Arterial Spin Labeling; a New Marker for Age and Age Related Neurological Diseases ...... 1136 Michael Edward Kelly, Christoph Wolfgang Blau, Ranya Bechara, Marina Anne Lynch, Christian Mattheis Kerskens

The Impact of Aging and Gender on Cerebral Viscoelasticity...... 1137 Ingolf Sack, Bernd Beierbach, Jens Wuerfel, Uwe Hamhaber, Dieter Klatt, Sebastian Papazoglou, Peter Martus, Braun Juergen

Quantification of Dynamic In Vivo 3-D Muscle Moment Arms Using Cine-PC MRI...... 1138 Nicole A. Wilson, Abrahm J. Behnam, Frances T. Sheehan

Prediction from Finite Element Modeling of Non-Uniform, Region-Dependent Strain of Muscle Fibers During Passive and Eccentric Rotation of the Ankle Confirmed by Phase Contrast MRI...... 1139 David Dongsuk Shin, John A. Hodgson, Sheng-Wei Chi, Jiun-Shyan Chen, V Reggie Edgerton, Shantanu Sinha

DTI Based Muscle Fiber Tractography in Humans at 4 Tesla Using Stimulated-Echos ...... 1140 R Allen Waggoner, Toshiaki Oda, Ryuta Kinugasa, Kenichi Ueno, Kang Cheng, Hideo Yokota, Ryutaro Himeno

Reproducibility of Diffusion Tensor Imaging in Human Forearm Muscles...... 1141 Martijn Froeling, Jos Oudeman, Sandra van den Berg, Klaas Nicolay, Mario Maas, Gustav Strijkers, Maarten Drost, Aart Nederveen

Proton MRS Acquisition Scheme with Long Echo Time and Without Water Suppression Simplifying IMCL Evaluation...... 1142 Jimin Ren, A. Dean Sherry, Craig R. Malloy

Optimal IMCL/EMCL Peak Separation and Full Visibility of the Dipolar Coupled Cr CH3 Resonance in Human Tibialis Anterior Muscle at 7T...... 1143 Hermien E. Kan, Maarten J. Versluis, Mark A. van Buchem, Andrew G. Webb

Kinetics of Muscle Lactate and High Energy Phosphates Measured by Localised Quantitative Interleaved MRS During Recovery from Ischaemic Exercise Define the Contributions of Lactate Oxidation, Lactate Efflux and Other Processes of Acid Efflux ...... 1144 Graham Kemp, Martin Meyerspeer, Ewald Moser

Metabolic Adaptations of Creatine Deficiency in Skeletal Muscle ...... 1145 Christine Nabuurs, Martijn Romeijn, Andor Veltien, Hermien Kan, Dirk Isbrandt, Arend Heerschap

DTI-Based Fiber Tracking Reveals a Multifaceted Alteration of Pennation Angle and Fiber Tract Length Upon Muscle Lengthening ...... 1146 Anneriet M. Heemskerk, Bruce M. Damon

Appearance of Histopathologic Changes of Rotator Cuff Tendons in MRI...... 1147 Florian M. Buck, Holger Grehn, Bernhard Jost, Monika Hilbe, Silvana Manzanell, Juerg Hodler

Quantitative MR in Multi-Center Clinical Trials...... 1148 Edward Ashton

Imaging Biomarkers in Multiple Sclerosis ...... 1149 Massimo Filippi

Imaging Biomarkers in Oncology...... 1152 Daniel C. Sullivan

Imaging Biomarkers in Cardiovascular Disease...... 1154 Chun Yuan

Grant Prospects for MRI Research: National Institutes of Health ...... 1155 Belinda Seto

Grant Prospects for MRI Research: European Union...... 1157 Mark A. Van Buchem

Critical Elements of a Successful Grant Proposal ...... 1159 Norbert J. Pelc

Your Grant Was Not Funded: What Do You Do Now?...... 1160 Richard L. Ehman

Manifestations of Hypertension on the Cardiovascular System ...... 1162 Giles H. Roditi

Fibromuscular Dysplasia: A Systemic Disease...... 1164 Martin R. Prince

Manifestations of Systemic Diseases on the CV System...... 1165 Tim Leiner

Manifestations of Systemic Diseases on the Cardiovascular System: Diabetes...... 1174 Sabine Weckbach

A Systematic Approach to MR Imaging of Vascular Malformations ...... 1176 Elizabeth M. Hecht

Diffusion Imaging ...... 1185 Christian Beaulieu

Perfusion Imaging ...... 1186 Roland Bammer

Functional MRI Methods for Clinicians...... 1193 Karla L. Miller

Genetic Influences on Economical Properties of Human Functional Cortical Networks ...... 1196 Alex Fornito, Andrew Zalesky, Danielle Bassett, David Meunier, Murat Yücel, Stephen J. Wood, Deborah Nertney, Bryan Mowry, Christos Pantelis, Ed Bullmore

Resting-State Functional Connectivity, Probabilistic Diffusion Tensor Tractography, and Histological Delineation in the Human Thalamus ...... 1197 Dongyang Zhang, Joshua S. Shimony, Abraham Z. Snyder, Michael D. Fox, Mark W. Sansbury, Marcus E. Raichle

Deafferentation Induced Cross-Hemispheric Brain Plasticity Detected by Resting-State Functional Connectivity Magnetic Resonance Imaging ...... 1198 Christopher Paul Pawela, Bharat B. Biswal, Rupeng Li, Anthony G. Hudetz, James S. Hyde

Volume 3

Functional MRI of Somatosensory Cortical Reorganization in the Rat Brain ...... 1199 Xin Yu, Shumin Wang, Stephen Dodd, Der-yow Chen, Alan Koretsky

Intrinsically Organized Low Frequency Network for Face Perception ...... 1200 Zhang Hui, Tian Jie

Spectral Clustering of Low-Frequency Fluctuations in fMRI Data Reveal a Distinct Separation Between the Superior Temporal Sulcus and the Superior Temporal Gyrus...... 1201 Gabriele Lohmann, Jonas Obleser, Angela Friederici, Robert Turner

Integration and Comparison of Brain Functional and Structural Connectivity Maps...... 1202 David C. Zhu, Shantanu Majumdar

An fMRI Study of Induced Plasticity in S1 in the Human Brain...... 1203 Rishma Vidyasagar, Laura Parkes

Analysis of Changes in Functional Connectivity Patterns with Serial Resting State fMRI After Transient Ischemic Stroke in Rat Brain ...... 1204 Kajo van der Marel, Maurits P. A. van Meer, Kun Wang, Willem Maarten Otte, Jan Willem Berkelbach van der Sprenkel, Rick M. Dijkhuizen

Connectivity Alterations in Motor-Related Areas Suggest Neuroplasticity in Chronic Stroke ...... 1205 Dionyssios Mintzopoulos, Loukas G. Astrakas, Azadeh Khanicheh, Angelos A. Konstas, Michael A. Moskowitz, Bruce R. Rosen, A. Aria Tzika

Qualitative and Quantitative Myocardial Perfusion with Arterial Spin Labeling...... 1206 Ulrike Blume, Matthias Guenther, Amedeo Chiribiri, Sven Plein, Tobias Schaeffter

Improved Arterial Spin Labeling After Myocardial Infarction in Mice Using Respiratory and Cardiac Gated Look-Locker Imaging with Fuzzy C-Means Clustering for T1 Estimation...... 1207 Moriel H. Vandsburger, Robert L. Janiczek, Brent A. French, Craig H. Meyer, Christopher M. Kramer, Frederick H. Epstein

Reconstruction of Free-Breathing Myocardial Perfusion MRI Using Simultanous Modeling of Perfusion and Motion (SMPM) and Arbitrary K-Space Sampling ...... 1208 Henrik Pedersen, Henrik B.W. Larsson, Rasmus Larsen

Myocardial Perfusion MRI Using SW-CG-HYPR in Canines with Improved Spatial Coverage, Resolution and SNR ...... 1209 Lan Ge, Aya Kino, Daniel Lee, Rohan Dharmakumar, Mark Griswold, Charles Mistretta, James Carr, Debiao Li

First Pass Contrast Enhanced MRI Shows Disparate Manifestations in Exercise-Induced Perfusion Improvement in Non-Transmural Infracted and Remote Myocardium ...... 1210 Mao-Yuan Marine Su, B-C Lee, Y-W Wu, H-Y Yu, W-C Chu, W-Y I. Tseng

Measurements of Myocardial Perfusion and Metabolism with MR: Validation Study with PET in a Canine Model...... 1211 Kyle Stephan McCommis, Thomas A. Goldstein, Dana R. Abendschein, Bernd Misselwitz, Robert J. Gropler, Jie Zheng

In Vivo Assessment of Calcium Influx in Alpha-Dystrobrevin Knock-Out Mouse by Manganese-Enhanced MRI ...... 1212 Wen Li, Jia Zhong, Ya Chen, Laurie Castel, Ming Lu, Wei Li, David van Wagoner, Xin Yu

New Methods for the Quantification of Myocardial Oxygen Consumption with 17O MRI ...... 1213 Kyle Stephan McCommis, Xiang He, Dana R. Abendschein, Pradeep M. Gupte, Robert J. Gropler, Jie Zheng

High Energy Phosphate Cardiac Energetics Are Abnormal in Primary Biliary Cirrhosis Patients in the Absence of Functional or Anatomical Abnormalities on Structural MRI...... 1214 Kieren Grant Hollingsworth, David EJ Jones, Jessie Pairman, Katherine Wilton, Roy Taylor, Julia Lindsay Newton, Andrew Mark Blamire

31P TRIple TR Saturation Transfer (TRIST) in the Human Heart at 3T...... 1215 Michael Schär, AbdEl Monem El-Sharkawy, Paul A. Bottomley, Robert G. Weiss

Validity of a 2-D Wave Field Model in MR Elastography of the Liver...... 1216 Meng Yin, Kevin J. Glaser, Jayant A. Talwalkar, Armando Manduca, Richard L. Ehman

Vitreal Viscoelasticity Revealed by Motion-Encoded MRI ...... 1217 Marco Piccirelli, Oliver Bergamin, Klara Landau, Peter Boesiger, Roger Luechinger

Application of DENSE MR-Elastography to the Human Heart: First in Vivo Results...... 1218 Benjamin Robert, Ralph Sinkus, Jean-Luc Gennisson, Mathias Fink

Auto-Elastography of the Brain...... 1219 Sha Zhao, Alan Jackson, Geoffrey J. Parker

Anomalous Shear Wave Propagation Reveals Micro-Architectural Properties - Potential Implications for Diagnostic Imaging...... 1220 Ralph Sinkus, Benoit Larrat, Najat Salameh, Katja Siegmann, Bernard Van Beers, Mathias Fink

High Resolution MR-Elastography Mouse Brain Study: Towards a Mechanical Atlas ...... 1221 Elsa Diguet, Elijah van Houten, Michael Green, Ralph Sinkus

A Protocol for Assessing Hepatic Fibrosis in Iron-Overloaded Liver Tissue with MR Elastography ...... 1222 David W. Stanley, Meng Yin, Kevin J. Glaser, Richard L. Ehman

TREMR: Table-Resonance Elastography with MR...... 1223 Daniel Gallichan, Matthew D. Robson, Andreas J. Bartsch, Karla L. Miller

MR Acoustic Radiation Force Imaging: In Vivo Comparison to Ultrasound Motion Tracking ...... 1224 Yuexi Huang, Laura Curiel, Aleksandra Kukic, Rajiv Chopra, Kullervo Hynynen

Proper Orthogonal Decomposition for Improved Assessment of Brain MR Elastography: Initial Results ...... 1225 Curtis L. Johnson, Dimitrios C. Karampinos, Danchin Chen, Bradley P. Sutton, William C. Olivero, John G. Georgiadis

Measuring the Concentration of Contrast Agent in Blood for DSC MRI from the Extra-Vascular Phase Shift ...... 1226 Samuel James Wharton, Natalia Petridou, Ashley E. Lotfipour, Penny A. Gowland, Richard Bowtell

Robust Quantification of Contrast Agent Concentration with Magnetic Field Correlation Imaging...... 1227 Vishal Patil, Glyn Johnson, Jens H. Jensen

The Effects of Equilibrium Intercompartmental Water Exchange Kinetics on MRI Estimation of Tissue Concentration of Contrast Agents...... 1228 Ramesh Paudyal, Hassan Bagher-Ebadian, Tavarekere Nagaraja, Swayam Panda, Joseph D. Fenstermacher, James R. Ewing

Gas-Filled Microbubbles as Intravascular R2 Contrast Agent for Liver MRI...... 1229 April M. Chow, Jerry S. Cheung, Alfred Yu, Hua Guo, Ed X. Wu

Repeatable First Pass DSC-MRI Measurements Using Saline as a Reverse-Effect Contrast Agent...... 1230 Christopher Chad Quarles, John Christopher Gore

Analysis of Partial Volume Effects on Arterial Input Functions Using Gradient Echo: A Simulation Study...... 1231 Birgitte Fuglsang Kjolby, Irene Klærke Mikkelsen, Michael Pedersen, Leif Oestergaard, Valerij G. Kiselev

Phase Contrast MRI Absolute Cerebral Blood Flow Estimation: A Method to Obtain Absolute Cerebral Blood Flow Maps from Dynamic Susceptibility Contrast Imaging ...... 1232 David Bonekamp, Peter B. Barker

A New Constrained Blind Estimation Algorithm for Determination of the Arterial Input Function Without Reference Tissues...... 1233 Matthias Christian Schabel, Edward V. R. Di Bella

Comparison of Arterial Blood Volume Obtained from Model-Free Arterial Spin Labelling (ASL) and Cerebral Blood Volume Obtained from Contrast Enhanced Dynamic Susceptibility Weighted Imaging (DSC) in Brain Tumours ...... 1234 Danielle van Westen, Linda Knutsson, Esben Thade Petersen, Karin Markenroth Bloch, Freddy Ståhlberg, Stig Holtås

Software Solution for Automated Assessment of DWI/PWI Mismatch in Acute Stroke Patients: The RAPID MISMATCH ...... 1235 Matus Straka, Maarten G. Lansberg, Gregory W. Albers, Roland Bammer

Differential Diagnosis of Neurodegenerative Dementias Using Structural MRI ...... 1236 Prashanthi Vemuri, Kejal Kantarci, Matthew L. Senjem, Jeffrey L. Gunter, Jennifer L. Whitwell, Keith A. Josephs, David S. Knopman, Bradley F. Boeve, Ronald C. Peterson, Clifford R. Jack Jr.

Brain Alternations in Alzheimer Disease and Frontotemporal Dementia: A Multimodal MRI Analysis ...... 1237 Yu Zhang, Norbert Schuff, Christopher Ching, Duygu Tosun, Marzieh Nezamzadeh, Wang Zhan, Howard J. Rosen, Joel H. Kramer, Maria Luisa Gorno-Tempini, Bruce L. Miller, Michael W. Weiner

Diffusivity Changes Are Predominantly Proportional Along All Axes with Early Neurodegeneration in Alzheimer's Disease...... 1238 Julio Acosta-Cabronero, Guy B. Williams, George Pengas, Peter J. Nestor

Comparing APOE Subgroups in Alzheimer's Disease Using Structural and Diffusion MRI ...... 1239 Nicola Filippini, Achim Gass, Andreas U. Monsch, Anil Rao, Brandon Whitcher, Paul M. Matthews, Stephen Smith

Aricept® Treatment Enhances Hippocampal Connectivity in Subjects with Mild Alzheimer’s Disease ...... 1240 Wenjun Li, Chunming Xie, Zhilin Wu, Jennifer Jones, Piero Antuono, Thomas McRae, Shi-Jiang Li

Cerebrovascular Reactivity as a Novel Marker in Assessing Vascular Dysfunction in Alzheimer’s Disease...... 1241 Uma Yezhuvath, Jinsoo Uh, Yamei Cheng, Kristin Martin-Cook, Myron Weiner, Matthias van Osch, Hanzhang Lu

Amplitude of Low Frequency Fluctuation of BOLD Signal and Resting-State Functional Connectivity Analysis of Brains of Parkinson's Disease ...... 1242 Qin Chen, Su Lui, Shu-Shan Zhang, He-Han Tang, Jian-Gang Wang, Xiao-Qi Huang, Qi-Yong Gong, Dong Zhou, Hui-Fang Shang

Tract-Based Spatial Statistics (TBSS) Study in Parkinson’s Disease Identifies Focal Microstructural Abnormality ...... 1243 Martyn Ezra, V Gontu, Maryam Abaei, Paul S. Morgan, Nin Bajaj, Dorothee P. Auer

Exploratory 7T MRS in Huntington’s Disease Gene Carriers...... 1244 Wouter Teeuwisse, Eve M. Dumas, Simon J. van den Bogaard, Hermien E. Kan, Raymund A. Roos, Mark A. van Buchem, Jeroen van der Grond

Quantification of Neurodegeneration in Amyotrophic Lateral Sclerosis (ALS) Using DTI and Iron Mapping ...... 1245 Christian Langkammer, Christian Enzinger, Stefan Quasthoff, Paula Grafenauer, Michaela Soellinger, Franz Fazekas, Stefan Ropele

Hybrid Diffusion Imaging (HYDI) in a Brain Model of Dysmyelination...... 1246 Yu-Chien Wu, Andrew L. Alexander, Ian D. Duncan, Aaron S. Field

Untangling a Fiber Bundle Knot - Preliminary Results on STN Connectivity Using DTI and HARDI on Rat Brains ...... 1247 Ellen Brunenberg, Vesna Prckovska, Bram Platel, Gustav Strijkers, Bart ter Haar Romeny

Diffusion Tensor Imaging and Micro-Computed Tomography Based Three Dimensional Stereotaxic Atlas of the Adult C57BL/6J Mouse Brain Corrected for Postmortem Tissue Deformation...... 1248 Manisha Aggarwal, Jiangyang Zhang, Michael I. Miller, Susumu Mori

Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of the White Matter Using Diffusion Tensor MR Imaging ...... 1249 Silun Wang, Ed. X. Wu, Kexia Cai, Ho-Fai Lau, Pek-Lan Khong

Diffusion Weighted Magnetic Resonance Imaging of Neuronal Activity in the Hippocampal Slice Model ...... 1250 Brian Hansen, Jeremy Flint, Peter Vestergaard-Poulsen, Stephen J. Blackband

DKI Visualizes Hippocampal Alterations in the Chronic Mild Stress Ratmodel ...... 1251 Rafael Delgado y Palacios, Marleen Verhoye, Johan Van Audekerke, Dirk Poot, Jan Sijbers, Ove Wiborg, Annemie Van der Linden

Myocardial Remodeling in Chronic Porcine Model: A DT-MRI Study Using the Toroid-Based Representation ...... 1252 Choukri Mekkaoui, Marcel P. Jackowski, Donald P. Dione, Francis G. Spinale, Albert J. Sinusas

In-Vivo Hadamard Encoded Continuous Arterial Spin Labelling (H-CASL) ...... 1253 Jack A. Wells, Mark F. Lythgoe, David Gadian, Roger Ordidge, David L. Thomas

Vessel Size Imaging with Iron Oxide and with Gadolinium: A Comparative Study in Rodent...... 1254 Nicolas Pannetier, Benjamin Lemasson, Thomas Christen, Régine Farion, Christoph Segebarth, Chantal Remy, Emmanuel Luc Barbier

Gd-DTPA-Enhanced MRI Revealed Leakage at Aqueous-Vitreous Interface Upon Ocular Hypertension ...... 1255 Kevin C. Chan, Qing-ling Fu, Kwok-fai So, Ed X. Wu

Automatic Heart Rate Dependent Timing Adjustments in Dark Blood Turbo-Spin Echo Sequences with and Without STIR Preparation...... 1256 Wolfgang G. Rehwald, Hannes Kutza, Peter Weale, Jeanette Schulz-Menger

Hybrid US/MR System for Real-Time Compensation of Breathing Motion Artifacts in Cardiovascular MRI at 3 Tesla ...... 1257 Daniel Giese, Andre Bongers, Jürgen Jenne, Matthias Günther, Bernd Jung, Daniela Foell, Maxim Zaitsev, Jürgen Hennig, Wim de Boer, Michael Markl

Real-Time Adaptive Suppression of MR Gradient Artifacts on Electrocardiograms Using a New 3D Hall Probe ...... 1258 Julien Oster, Joris Pascal, Olivier Pietquin, Michel Kraemer, Jean-Philippe Blondé, Jacques Felblinger

An Alternative Concept for Non-Sequence Interfering, Contact-Free Respiration Monitoring...... 1259 Ingmar Graesslin, Henry Stahl, Kay Nehrke, Paul Harvey, Jouke Smink, Giel Mens, Andreas Senn, Peter Börnert

Assessing and Correcting Respiration Induced Variation of B1 in the Liver ...... 1260 Francesco Padormo, Shaihan Malik, Joseph V. Hajnal, David J. Larkman

High Precision Translational Motion Correction for Micro-MRI of Trabecular Bone Using Cartesian Navigators...... 1261 Hamidreza Saligheh Rad, Micheal J. Wald, Jeremy F. Magland, Felix W. Wehrli

3D SAP-EPI Motion-Corrected Fast Susceptibility Weighted Imaging...... 1262 Samantha J. Holdsworth, Stefan Skare, Karley Marty, Matus Straka, Roland Bammer

Motion Compensation with Floating Navigator and GRAPPA Operators...... 1263 Wei Lin, Feng Huang, Yu Li, Charles Saylor, Arne Reykowski

Multi Channel Self Navigated Motion Correction...... 1264 Jason Mendes, Dennis L. Parker

MR-Assisted PET Motion Correction for Neurological Applications...... 1265 Ciprian Catana, Andre van der Kouwe, Thomas Benner, Michael Hamm, Bastien Guerin, Larry Byars, Christian Michel, Georges El Fakhri, Matthias Schmand, Bruce R. Rosen, A. Gregory Sorensen

Virtual Body Coil Calibration for Phased-Array Imaging...... 1266 Martin Buehrer, Peter Boesiger, Sebastian Kozerke

Automated Coil Subset Selection for Improved GRAPPA Reconstruction...... 1267 Keith Heberlein

Efficient “O-Space” Parallel Imaging with Higher-Order Encoding Gradients and No Phase Encoding...... 1268 Jason Peter Stockmann, Pelin Aksit Ciris, Robert Todd Constable

Noise Behavior of Cartesian PatLoc Reconstruction ...... 1269 Gerrit Schultz, Maxim Zaitsev, Peter Ullmann, Heinrich Lehr, Jürgen Hennig

3D Undersampled Golden-Radial Phase Encoding Using Iterative Reconstructions and Inherent Regularization...... 1270 Claudia Prieto, Sergio Uribe, Philip Batchelor, Pablo Irarrazaval, Reza Razavi, David Atkinson, Tobias Schaeffter

Automatic Design of Radial Trajectories for Parallel MRI and Anisotropic Fields-Of-View...... 1271 Alexey A. Samsonov

Feasibility of Five-Minute Comprehensive Cardiac MR Examination Using Highly Accelerated Parallel Imaging with a 32-Element Coil Array ...... 1272 Jian Xu, Ricardo Otazo, Sven Zuehlsdorff, Daniel Kim, Xiaoming Bi, Qi Duan, Sonia Nielles-Vallespin, Monvadi Barbara Srichai, Thoralf Niendorf, Renate Jerecic, Bernd Stoeckel, Yao Wang, Li Feng, Kellyanne Mcgorty, Daniel K. Sodickson

Highly-Accelerated Cardiac Cine MR Imaging Using Kats ARC (Autocalibrating Reconstruction for Cartesian Sampling with K- & Adaptive-T-Space Data Synthesis) ...... 1273 Peng Lai, Anja C. Brau, Philip J. Beatty, Ajit Shankaranarayanan

Real-Time Non-Gated Cardiac MRI Using PARADISE: Doubly Adaptive Accelerated Imaging...... 1274 Behzad Sharif, John Andrew Derbyshire, Anthony Z. Faranesh, Robert J. Lederman, Yoram Bresler

Auto-Calibrated Parallel Imaging Using the Unused Echo in Alternating TR SSFP...... 1275 Hsu-Lei Lee, Yoon-Chul Kim, Ajit Shankaranarayanan, Krishna S. Nayak

Fat-Water Imaging...... 1276 Scott B. Reeder

Image Reconstruction 2009: Motion Correction...... 1277 David J. Larkman

Accidents in MRI...... 1283 Anne M. Sawyer

Risks of Acoustic Noise in the MR Environment...... 1289 David L. Price

Resting State BOLD Calibration ...... 1292 Rasmus Birn

Muscle, IMCL, EMCL and Muscle Metabolism In Vivo...... 1297 Chris Boesch

Lipotoxicity, Diabetes, Steatosis, Steatohepatitis, Preclinical Animal Models ...... 1299 Rheal Antoine Towner

MRS of Myocardial and Hepatic Triglyceride in Human Health and Disease ...... 1301 Linda S. Szczepaniak

The Bioartificial Pancreas, NMR and You!...... 1302 Nicholas E. Simpson

Sodium and T1-rho MR Analysis of Bioengineered Cartilage...... 1305 George R. Dodge

Cartilage and Heart Valve Tissue Engineering: Working Towards Noninvasive Construct Analysis ...... 1307 Sharan Ramaswamy

Role of Cortical and Trabecular Bone Architecture in Osteoporosis...... 1308 Felix W. Wehrli

Articular Cartilage: From Form to Function...... 1313 Hollis G. Potter

Transmitter Arrays for Cardiac Imaging at 7T...... 1325 Thomas Vaughan

Cardiac MRI at 7T ...... 1329 Matthew D. Robson

7T Cardiovascular MRI: Is th Pain Worth the Gain?- Vascular ...... 1334 Mark E. Ladd

MRS in Mice Models of Neurodegenerative Disorders...... 1336 Ivan Tkac

Measurements of Glutamate/GABA/Glutamine Cycling in the Mouse Brain...... 1340 Kevin L. Behar

MR Findings without Clinical Significance ...... 1342 Christian Glaser

Clinical Abnormalities not Detectable on MR Images ...... 1343 Christine Chung

All in One: Whole Body Cancer Imaging ...... 1345 Heinz-Peter W. Schlemmer

Solving Gordic’s Node: Dedicated LN Imaging...... 1349 Jelle O. Barentsz

Molecular Pathobiology of Prostate Cancer...... 1351 Angelo M. De Marzo

Staging, Diagnosis & Detection, State of Art Imaging, Methodology, and Etc...... 1352 John Kurhanewicz

Radiation Therapy, Guided Therapy and Related Topics...... 1353 Jelle O. Barentsz

The Equivalent Magnetization Current Method Applied to the Design of Gradient Coils for MRI...... 1354 Hector Sanchez, Michael Poole, Feng Liu, Stuart Crozier

Curved Planar Gradient Coil Design Using the Boundary Element Method...... 1355 Chad Harris, Blaine Alexander Chronik

Cool Gradient Coils Designed with Adaptive Regularisation ...... 1356 Michael Poole, Hector Sanchez Lopez, Adnan Trakic, Stuart Crozier

Design of a Cylindrical Passive Shim Insert for Human Brain Imaging at High Field...... 1357 Mohan Jayatilake, Judd Storrs, Jing-Huei Lee

A Transverse Gradient Detection Coil for Dynamic Pre-Emphasis...... 1358 Karl Edler, David I. Hoult

Dynamic Bo Shimming at 7 Tesla...... 1359 Saikat Sengupta, Brian E. Welch, Yansong Zhao, David Foxall, Piotr Starewicz, Adam Anderson, Malcolm Avison, John Gore

Towards Dynamic Shimming in a 31cm Bore 9.4T System: Analysis of Shim-Shim Inductive Interactions...... 1360 Dustin Wesley Haw, Blaine Alexander Chronik

Improving the Efficiency of Digitally Controlled Switching Gradient Amplifiers for Driving Different Gradient Insert Coils ...... 1361 Francisco Manuel Martinez-Santiesteban, Jian-xiong Wang, Brian K. Rutt

A Third-Order Field Camera with Microsecond Resolution for MR System Diagnostics ...... 1362 Christoph Barmet, Bertram J. Wilm, Matteo Pavan, Klaas P. Pruessmann

Continuous Magnetic Field Mapping with Pulsed 1H NMR Probes...... 1363 Pekka Sipilä, James Tropp, Sebastian Greding, Gerhard Wachutka, Florian Wiesinger

Prostate Cancer Detection: Multi-Parametric MRI with Diffusion-Weighted Imaging and Dynamic Contrast Enhanced MRI...... 1364 Deanna Lyn Langer, Theo H. van der Kwast, Andrew J. Evans, John Trachtenberg, Brian C. Wilson, Masoom A. Haider

Final Results of IMAPS: An International Multi-Centre Assessment of Prostate MR Spectroscopy ...... 1365 Tom WJ Scheenen, Jurgen J. Fütterer, Elisabeth Weiland, Paul van Hecke, Marc Lemort, Christian M. Zechmann, Heinz-Peter Schlemmer, Dale R. Broome, Geert M. Villeirs, Jaoping Lu, Jelle O. Barentsz, Stefan O. Roell, Arend Heerschap

Which DCE MRI Parameter Provides the Best Discrimination Between Prostate Cancer and Benign Tissue?...... 1366 Louisa Bokacheva, Kiran Sheikh, Henry Rusinek, Artem Mikheev, Danny Kim, Xiangtian Kong, Jonathan Melamed, Bachir Taouli

Apparent Diffusion Coefficient as a Predictive Biomarker of Prostate Cancer Progression: Value of Fast and Slow Diffusion Components...... 1367 Sharon L. Giles, Veronica A. Morgan, Sophie F. Riches, Karen Thomas, Chris Parker, Nandita M. De Souza

Correlation Between Pretreatment MRI/MRSI Data and Tissue Molecular Marker Levels for Characterization of Prostate Cancer and Prediction of Disease Recurrence...... 1368 Amita Shukla-Dave, H. Hricak, N. Ishill, C. S. Moskowitz, M. Drobnjak, V. E. Reuter, K. L. Zakian, P. T. Scardino, C. Cordon- Cardo

Diffusion-Weighted MRI to Detect Pelvic Lymph Node Metastases in Patients with Bladder or Prostate Cancer: Comparison with Histopathology as Gold Standard...... 1369 Maria Triantafyllou, Tobias Binser, Frederic Birkhaeuser, Urs E. Studer, Achim Fleischmann, Michael Von Gunten, Johannes M. Froehlich, Peter Vermathen, Harriet C. Thoeny

Correlation Between Lymph Node Apparent Diffusion Coefficient and Positron Emission Tomography Standardised Uptake Value in Paediatric Patients with Lymphoma ...... 1370 Shonit Punwani, Steve Bandula, Vineet Prakash, Alan Bainbridge, Enrico De Vita, Nicola Stevens, Stuart Taylor, Sharon Hain, Stephen Daw, Ananth Shankar, Paul Humphries

Prediction of Treatment Response in Follicular and Mantle Cell Lymphomas Using In Vivo 31P MRS Before Treatment ...... 1371 Fernando Arias-Mendoza, Geoffrey Payne, Kristen Zakian, Marion Stubbs, Hamed Mojahed, Amita Shukla-Dave, Nicholas R. Maisey, David Cunningham, Harish Poptani, Mitchell R. Smith, Owen A. O'Connor, Jazmine Zain, Steven J. Shuster, Andrew D. Zelenetz, George A. Follows, John Raemaekers, Marius MacKenzie, Martin O. Leach, Jason A. Koutcher, John R. Griffiths, Arend Heerschap, Jerry D. Glickson, Truman R. Brown

Taurine- A Possible Biomarker in Urine of Urinary Bladder Cancer by 1H NMR Spectroscopy: A Pilot Study...... 1372 Abhinav Arun Sonkar, Shatakshi Srivastava, Sudhir Singh, Diwakar Dalela, Satya Narayanan Sankhwar, Apul Goel, Raja Roy

Characterization and Evaluation of Metabolic Biomarkers for Human Colon Adenocarcinomas by 1H HR MAS Spectroscopy...... 1373 May-Britt Tessem, Kirsten M. Selnæs, Wenche Sjursen, Gerd Tranø, Ingrid Gribbestad, Eva Hofsli

Striatal Dopamine Correlates Brain Activation in Precuneus and Thalamus: A PET-fMRI Study ...... 1374 Dardo Tomasi, Nora D. Volkow, Ruiliang L. Wang, Frank Telang, Gene-Jack Wang, Joanna S. Fowler

Caffeine's Effects on Resting-State Oxygen and Glucose Metabolism: A Combined MR and PET Study ...... 1375 Yufen Chen, Andrew B. Newberg, Jiongjiong wang, Hengyi Rao, Hongyu An, Joel Greenberg, Nancy Wintering, Victoria Tolles, John A. Detre fMRI of Cocaine Self-Administration in Non-Human Primates...... 1376 Ji-Kyung Choi, Helen Deng, Wim Vanduffel, Joseph B. Mandeville

Effects of Low-Dose Sevoflurane on Regional CBF and BOLD Responses to Auditory Stimulation of Varying Rate and Volume ...... 1377 Maolin Qiu, Ramachandran Ramani, Vivien Rekkas, Nallakkandi Rajeevan, Fuyuze S. Tokoglu, Robert Todd Constable

How Antidepressants Work: SSRI Treatment Induces Adaptive Changes in Brain 5-HT PhMRI Responses ...... 1378 Darragh Downey, Karen E. Davies, Shane McKie, Gabriella Juhasz, Ian M. Anderson, Mark A. Smith, John-Francis William Deakin, Steve R. Williams

Face Processing and 5-HT: Chronic Citalopram Treatment on BOLD Responses...... 1379 Karen Elizabeth Davies, Darragh Downey, Shane McKie, Gabriella Juhasz, Ian Anderson, Mark A. Smith, John-Francis William Deakin, Stephen Ross Williams

Effect of Muscimol on BOLD and Local Neuronal Activity in Awake Animals ...... 1380 Daniil P. Aksenov, Limin Li, Gheorghe Iordanescu, Xiaomu Song, Alice Wyrwicz

Double-Blind, Placebo-Controlled, Dose-Response fMRI Trial of Buprenorphine: Differential Valence of BOLD Response Modulation to Innocuous and Noxious Stimuli in Sensory and Striatal Regions ...... 1381 Jaymin Upadhyay, Julie Anderson, Adam J. Schwarz, Richard Baumgartner, Alexandre Coimbra, Jaime Knudsen, Ed George, James Bishop, Sanjay Keswani, Brigitte Robertson, Rudy Schreiber, David Bleakman, Richard Hargreaves, Lino Becerra, David Borsook

Regional fMRI Activation in Response to Visceral Stimulation in Rats with Amygdala Implants of Corticosterone ...... 1382 Jelena Lazovic, Anthony C. Johnson, Brent Myers, Rheal Towner, Beverly Greenwood-Van Meerveld

Investigate the Mechanisms of Anesthetic-Induced Unconsciousness in a Mouse Model by High-Resolution Manganese Enhanced MRI (MEMRI) Technique: A Preliminary Study ...... 1383 Ping Wang, Jason Moore, Thomas Floyd, Max Kelz

SWIFT Detection of SPIO Labeled Stem Cells Grafted in the Myocardium ...... 1384 Rong Zhou, Djaudat Idiyatullin, Steen Moeller, Curt Corum, Hualei Zhang, Michael Garwood

Fast Positive-Contrast Imaging of SPIO-Labeled Cells with Low-Angle Alternating-TR SSFP...... 1385 Tolga Çukur, Mayumi Yamada, William R. Overall, Phillip Yang, Dwight G. Nishimura

UTE Imaging for Single Cell Detection with Positive Contrast ...... 1386 Clemens Diwoky, Andreas Reinisch, Dieter Gross, Volker Lehmann, Dirk Strunk, Rudolf Stollberger

3D Radial UTE Imaging for Quantification of Transplanted Iron Oxide Labelled Islet Cells ...... 1387 Lindsey Alexandra Crowe, Frederic Ris, Sonia Nielles-Vallespin, Peter Speier, Solange Masson, Mathieu Armanet, Domenico Bosco, Thierry Berney, Jean-Paul Vallée

Multi-Color 19F CSI: Simultaneous Detection of Differently Labeled Cells in Vivo...... 1388 Thomas Christian Basse-Lüsebrink, Gesa Ladewig, Thomas Kampf, Gerd Melkus, Daniel Haddad, Wolfgang Rudolf Bauer, Peter M. Jakob, Guido Stoll

Dynamic Manganese-Enhanced MRI Reveals Dominant Modulation of Myocardial L-Type Calcium Channel Flux by Neuronal, Not Endothelial Nitric Oxide Synthase in Mice...... 1389 Moriel H. Vandsburger, Brent A. French, Christopher M. Kramer, Frederick H. Epstein

Assessment of Myocardial Ca2+ Dysregulation Using Mn Enhanced MRI ...... 1390 Janaka Wansapura, Doug Millay, Jeff Molkentin, Woody Benson

High Throughput MRI Method for in Vitro CEST Agent Screening ...... 1391 Guanshu Liu, Assaf A. Gilad, Jeff W.M. Bulte, Peter C.M. van Zijl, Michael T. McMahon

High Resolution MR Imaging of Brain Lactate Using Selective Saturation Transfer ...... 1392 Christopher Lascola, Talignair Venkatraman, Sean Snodgress, Haichen Wang

Delta Relaxation Enhanced MR: Experimental Validation ...... 1393 Jamu K. Alford, Brian K. Rutt, Timothy J. Scholl, William B. Handler, Blaine A. Chronik

In-Line Automated Tracking in Cardiac Cine MRI ...... 1394 Bo Li, Yingmin Liu, Brett Raymond Cowan, Alistair Andrew Young

Accurate Assessment of Ventricular Volumes in a Single Breath Hold Using a 32-Channel Coil and an Extracellular Contrast Agent...... 1395 Victoria Parish, Sergio Uribe, Gerald Greil, Tobias Schaeffter

Influence of Outflow Tract Reconstruction on Long-Term Right Ventricular Function and Pulmonary Regurgitation After Repair of Tetralogy of Fallot: A Clinical Magnetic Resonance Imaging Study...... 1396 C-A Chen, J-K Wang, M-H Wu, M-Y Su, H-Y Yu, C-I Chang, I-S Chiu, I-S Chen, W-Y Isaac Tseng

Model-Based Reconstruction for Free-Breathing Cardiac CINE Imaging Using GRICS...... 1397 Pierre-André Vuissoz, Freddy Odille, Brice Fernandez, Maelene Lohezic, Adnane Benhadid, Damien Mandry, Jacques Felblinger

Measuring Changes in Morphology, Hemodynamics, and Mechanical Function by Controlling Ventricular Preload Using an MRI-Compatible Lower Body Negative Pressure Chamber ...... 1398 June Cheng Baron, Jessica Scott, Ben Esch, Kelvin Chow, Ian Paterson, Mark Haykowsky, Richard Thompson

In Vivo Validation of Fast Cine DENSE MRI for the Quantification of Regional Cardiac Function...... 1399 Li Feng, Robert M. Donnino, James Babb, Leon Axel, Daniel Kim

Comparison of DENSE Reference Strategies...... 1400 Henrik Haraldsson, Andreas Sigfridsson, Hajime Sakuma, Tino Ebbers

Navigator-Gated 3D Cine DENSE MRI of the Left Ventricle...... 1401 Xiaodong Zhong, Craig H. Meyer, Christopher M. Kramer, Frederick H. Epstein

A Practical Estimator for Interventricular Mechanical Asynchrony in Pulmonary Arterial Hypertension...... 1402 Gert Jan Mauritz, J. Tim Marcus, Anton Vonk-Noordegraaf

7T Human In Vivo Cardiac Imaging with an 8-Channel Transmit/Receive Array ...... 1403 Stefan Maderwald, Stephan Orzada, Lena C. Schäfer, Andreas K. Bitz, Irina Brote, Oliver Kraff, Jens M. Theysohn, Mark E. Ladd, Susanne C. Ladd, Harald H. Quick

Sub-Nanoliter Microscopic MR Imaging of the Human Skin in Vivo Using a 12 Mm Superconducting Surface Coil at 1.5 Tesla...... 1404 Elmar Laistler, Marie Poirier-Quinot, Jean-Christophe Ginefri, Simon Lambert, Rose-Marie Dubuisson, Emeline Boriasse, Ewald Moser, Luc Darrasse

Diffusion Weighted Imaging of Human Articular Cartilage Using Fractional Calculus Model: Preliminary Study...... 1405 Xu Feng, Richard L. Magin, Jun Li, Carol Muehleman

Hypoxic Environments and the Extracellular Matrix: MRI and Second Harmonic Generation Microscopy Studies ...... 1406 Samata m. Kakkad, Meiyappan Solaiyappan, Kristine Glunde, Brian O’Rourke, Arvind Pathak, Venu Raman, Marie-France Penet, Zaver M. Bhujwalla

Phenotyping in the Mouse Embryo Using a µMRI Atlas...... 1407 Jon Orlando Cleary, Marc Modat, Anthony Nathan Price, Nicholas D. Greene, David L. Thomas, Peter J. Scambler, Roger J. Ordidge, S Ourselin, Mark Francis Lythgoe

MRI and OPT Comparison for Mouse Embryonic Development ...... 1408 Michael David Wong, Jacob Ellegood, Jun Dazai, X Josette Chen, R Mark Henkelman

True MR Microscopy on a Clinical 7 Tesla Scanner: Application to Plaque Detection in Ex Vivo HCHWA-D Samples ...... 1409 Andrew Webb

MR Microscopy of Human Skin Vasculature in Vivo at 3 Tesla Using a Small Copper Surface Coil...... 1410 Elmar Laistler, Ewald Moser

MRI Tissue Window Chamber System for Validation and Optimization of Dynamic Contrast Enhanced Tumor Imaging ...... 1411 Olivier Maciej Girard, Ahmet Erten, Mark Bydder, Milan T. Makale, David A. Cheresh, David Gilderdale, Sadik Esener, Robert Frederick Mattrey

Blood Volume Fraction Measurements Using MRI: A Correlation Between Two-Photon and in Silico MR Estimates...... 1412 Thomas Christen, Nicolas Joudiou, Raphael Serduc, Gregoire Malandain, Nicolas Pannetier, Jean-Claude Vial, Christoph Segebarth, Chantal Rémy, Emmanuel L. Barbier

An Oxygen Consuming Phantom for Simulating Oxygen Perfusion in Tissue Using 19F MRI Oximetry ...... 1413 Steven H. Baete, Yves De Deene

Deep Gray Matter T2 Hypointensity Correlates with Disability in a Murine Model of MS ...... 1414 Istvan Pirko, Aaron J. Johnson, Anne K. Lohrey, Jun Ying, Diana Lindquist, R. Scott Dunn

T2 Relaxation Parallels Progressive Clinical Symptoms of Demyelination in a Novel Transgenic Mouse Model...... 1415 Thomas Mueggler, Hartmut Pohl, Dieter Riethmacher, Christof Baltes, Ueli Suter, Markus Rudin

Neural Precursor Migration Following Intracerebroventricular Delivery During the Chronic Phase of Experimental Allergic Encephalomyelitis Is Reduced as Compared to the Acute Phase ...... 1416 Naser Muja, Mikhal Cohen, Jiangyang Zhang, Assaf A. Gilad, Piotr Walczak, Tamir Ben-Hur, Jeff W.M. Bulte

MRI Estimation of Sub-Clinical Disease in Japanese Macaque Encephalomyelitis...... 1417 William D. Rooney, Steven G. Kohama, Paul Wang, Jeffrey M. Njus, Scott W. Wong, Lawrence S. Sherman, Michael K. Axthelm, Gail H. Marracci, Dennis N. Bourdette

Q-Space and Conventional DWI of Axonal and Myelin Damage in the Rat Spinal Cord After Axotomy ...... 1418 Jonathan Andrew David Farrell, Jiangyang Zhang, Melina Jones, Cynthia A. DeBoy, Paul N. Hoffman, Seth A. Smith, Daniel S. Reich, Peter A. Calabresi, Peter C. van Zijl

Diffusion Anisotropy Correlates Compound Action Potential in the Optic Nerve from Mice of Retina Ischemia...... 1419 Qing Wang, Roman Vlkolinsky, Sheng-Kwei Song, Andre Obenaus

White Matter Changes in a Model of Temporal Lobe Epileptogenesis: A Combined Diffusion Tensor Imaging and Histopathology Study ...... 1420 Willem Maarten Otte, Pieter van Eijsden, W. S. van der Hel, O. van Nieuwenhuizen, Rick M. Dijkhuizen, R A. de Graaf, Kees P.J. Braun

Long-Term Treatment with Antipsychotics Affects NAA T1 in Normal Rat Brain...... 1421 Diana M. Lindquist, R S. Dunn

Imaging Model of Antidepressant Effects: A Pre-Clinical Investigation Using Pharmacological Magnetic Resonance Imaging...... 1422 Sakthivel Sekar, Marleen Verhoye, Johan Van Audekerke, Greetje Vanhoutte, Andrew M. Blamire, Thomas Steckler, Mohammed Shoaib, Annemie Van der Linden

Pathological Correlates of the Decreased Axial Diffusivity in White Matter Injury...... 1423 Mingqiang Xie, Matthew D. Budde, Chin-I Chen, Kathryn Trinkaus, Regina C. Armstrong, Anne H. Cross, Sheng-Kwei Song

Bulk Susceptibility Mapping Using Ultrashort TE Spectroscopic Imaging (UTESI)...... 1424 Jiang Du, Alan Chiang, Atsushi M. Takahashi, Christine B. Chung, Graeme M. Bydder

Creating Short T2 Contrast with Three-Dimensional Ultrashort TE (3D UTE) Imaging...... 1425 Jiang Du, Atsushi M. Takahashi, Sheronda Statum, Reni Biswas, Christine B. Chung, Graeme M. Bydder

Detection of Short-Term Temporal Changes in Mechanical Properties of Bone in Early Postmenopausal Women Using µMRI………………………………………………………………………………………………………………………………………1426 Chamith S. Rajapakse, Jeremy Magland, Peter J. Snyder, Felix W. Wehrli

MR Multi-Parametric Approach to Evaluate Osteoporosis at 3T: T2, T2, ADC, Gi and 1H-MRS Measurements in Healthy, Osteopenic and Osteoporotic Subjects ...... 1427 Silvia Capuani, Mauro Rebuzzi, Fabrizio Fasano, Gisela Hagberg, Marco Di Mario, Bruno Maraviglia, Vincenzo Vinicola

Combined Water and Fat Suppressed Proton Projection MRI (WASPI) and Micro CT Measurement of Bone Mineralization...... 1428 Haihui Cao, Jerome Ackerman, Thomas D. Crenshaw, Patricia Dunning, Melvin Glimcher, Yaotang Wu

Magnetic Resonance Elastography in Trabecular Bone: Preliminary Results ...... 1429 Jun Chen, Hugh McGregor, Kevin Glaser, Yogesh Mariappan, Arunark Kolipaka, Richard Ehman

The Ultrastructure of Bone Using Selective Saturation in SWIFT at 9.4 T...... 1430 Jutta Ellermann, Djaudat Idiyatullin, Curt Corum, Steen Moeller, Wen Ling, Michael Garwood

Registration of MR Trabecular Bone Images of the Proximal Femur in a Longitudinal Study...... 1431 Janet Blumenfeld, Julio Carballido-Gamio, Jenny Folkesson, Dana Carpenter, Thomas M. Link, Sharmila Majumdar

Correlation of MRI and Histological Examination of Physeal Bars in a Rabbit Model ...... 1432 Matthew F. Koff, LeRoy Chong, Patrick Virtue, Liang Li Ying, Li Foong Foo, Hollis Potter

Examination of the Correlation Between Hypervascularity and Physeal Bone Bridge Formation...... 1433 Bernhard Neumayer, Eva Elisa Fischerauer, Clemens Diwoky, Annelie-Martina Weinberg, Rudolf Stollberger

Graph-Based Tractography for Robust Propagation Through Complex Fibre Configurations ...... 1434 Stamatios N. Sotiropoulos, Li Bai, Paul S. Morgan, Christopher R. Tench

ICA Based Multi-Fiber Tractography ...... 1435 Manbir Singh, Chi-Wah Wong

A Hough Transform Global Approach to Diffusion MRI Tractography ...... 1436 Iman Aganj, Christophe Lenglet, Renaud Keriven, Guillermo Sapiro, Noam Harel, Paul Thompson

A New Approach to Fully Automated Fiber Tract Clustering Using Affinity Propagation...... 1437 Alexander Leemans, Derek K. Jones

Automatic Segmentation of White Matter Structures from DTI Using Tensor Invariants and Tensor Orientation...... 1438 Rodrigo de Luis Garcia, Carlos Alberola Lopez, Gordon Kindlmann, Carl-Fredrik Westin

Semantic and Phonological Processing in the Left Inferior Frontal Gyrus: Observations from a Combined Distortion Corrected fMRI and Tractography Study ...... 1439 Karl V. Embleton, Geoff J. Parker, David M. Morris, Hamied A. Haroon, Matt A. Lambon Ralph

Predicting Resting-State Functional Connectivity from Structural Connectivity ...... 1440 Chris J. Honey, Olaf Sporns, Leila Cammoun, Xavier Gigandet, Jean-Philippe Thiran, Reto Meuli, Patric Hagmann

Fully Automated Probabilistic White-Matter Tractography with Anatomical Priors: Application to Huntington's Disease...... 1441 Anastasia Yendiki, Allison Stevens, Jean Augustinack, David Salat, Lilla Zollei, Ruopeng Wang, Diana Rosas, Bruce Fischl

Asymmetries in Chimpanzees (Pan Troglodytes) Corticospinal System - A Diffusion Magnetic Resonance Imaging (MRI) Study ...... 1442 Longchuan Li, Todd M. Preuss, James K. Rilling, William D. Hopkins, Matthew F. Glasser, Bhargav Kumar, Roger Nana, Xiaodong Zhang, Xiaodong Hu

Diffusion Tensor Tractography of Individual Nerve Fibers in the Ventral Spinal Cord of the Rat with Histological Validation ...... 1443 Jeremy J. Flint, Brian Hansen, Michael Fey, Daniel Schmidig, Michael A. King, Peter Vestergaard-Poulsen, Stephen J. Blackband

Contribution of Protein-Induced Magnetic Susceptibility and 1H Exchange Effects to Water MR Frequency Shifts ...... 1444 Jie Luo, Xiang He, D. Andre' d'Avignon, Joseph J. H. Ackerman, Dmitriy A. Yablonskiy

On the Nature of Phase Contrast in Gradient Echo MRI:A Generalized Lorentzian Approach ...... 1445 Xiang He, Dmitriy A. Yablonskiy

Molecular Size Dependency of Water Macromolecule Exchange Induced Frequency Shift...... 1446 Kai Zhong, Karl-Heinz Smalla, Alexander Brensing, Oliver Speck

The Role of Intravascular Effects in Phase Contrast Between Gray and White Matter ...... 1447 Natalia Petridou, Samuel J. Wharton, Ashley Lotfipour, Penny Gowland, Richard Bowtell

Balanced SSFP Profile Asymmetries Are Sensitive to White Matter Tract Structure...... 1448 Karla L. Miller, Peter Jezzard, Stephen M. Smith

On the Cause of Transient Off-Resonance Stopbands in TIDE BSSFP Imaging ...... 1449 Yin-Cheng Kris Huang, Teng-Yi Huang, Wen-Chau Wu, Ying-Po Liao, Hsiao-Wen Chung

High Positive Contrast Generation of a Subvoxel Susceptibility Deviation in Ultrashort TE (UTE) Radial Center- Out Imaging at 3T ...... 1450 Peter Roland Seevinck, Hendrik de Leeuw, Clemens Bos, Chris J.G. Bakker

Adiabatic Pulse Preparation for Imaging Iron Oxide Nanoparticles...... 1451 Steven Harris, Xiaoping Hu

Cyclic Motion Encoding for Enhanced MR Visualization of Slip Interfaces ...... 1452 Yogesh Kannan Mariappan, Kevin J. Glaser, Armando Manduca, Richard L. Ehman

Improved Transverse Relaxometry: A New Fitting Model with Stimulated Echo Compensation ...... 1453 Robert Marc Lebel, Alan H. Wilman

Particle Embedded Culture Dishes for Magnetic Cell Labeling ...... 1454 Dorit Granot, Erik M. Shapiro

Intracellular MRI Contrast by SPIOs and Dy Chelates at 11.75 and 21.1 T ...... 1455 Jens Thorvald Rosenberg, Joshua M. Kogot, Chris Ridel, Geoffery F. Strouse, Samuel C. Grant

Simplified Synthesis and Characterization of Magnetoferritin for Convection Enhanced Delivery...... 1456 Veronica Clavijo Jordan, Michael R. Caplan, Kevin M. Bennett

Early Detection of Sepsis by Quantifying SPIO Uptake by LPS-Activated Macrophages Using COSMOS...... 1457 Richard Wong, Tian Liu, Jian Shou, Philip S. Barie, Yi Wang

In Vivo Tracking of Biomaterial Degradation of Hydrogels Synthesized with Protein Polymer-Based Contrast Agents...... 1458 Emily Alexandria Waters, Lindsay Karfeld-Sulzer, Ellen Kohlmeir, Hermann Kissler, Xiaomin Zhang, Dixon Kaufman, Annelise Barron, Thomas Meade

About the Origins of Enhanced Visualization of Amyloid Plaques on APP/PS1 Mouse Brain Using GdDOTA Passive Staining ...... 1459 Benjamin Marty, Julien Flament, Julien Valette, Fawzi Boumezbeur, Marc Dhenain, Franck Lethimonnier, Sébastien Mériaux

Equilibrium and Kinetic Properties of Gd(III)AAZTA Complex a Highly Efficient MRI Contrast Agent...... 1460 Fulvio Uggeri, Alessandro Maiocchi, Silvio Aime, Erno Brucher, Zsolt Baranyai, Attila Benyei

New Family of Dendrimeric Ligands as MRI Contrast Agents ...... 1461 Jesus Pacheco-Torres, Francisco Fernández-Trillo, Eduardo Fernández-Megía, Ricardo J. Riguera, Paloma Ballesteros, Pilar Lopez-Larrubia, Sebastian Cerdan

Nanocontrast Agents for In Vivo Probing on Non-Small Cell Lung Cancer in MR Molecular Imaging ...... 1462 Ching-Tang Chen, Chia-Hao Su, Yi-Chien Lu, Ang Yuan, Jyh-Horng Chen

Cardiac Magnetic Resonance to Detect Cell Death in Vivo...... 1463 Rajesh Dash, Trevor Chan, Mayumi Yamada, Marietta Paningbatan, Philip Swigart, Bat-Erdene Myagmar, Paul C. Simpson, Phillip C. Yang

Contrast Enhanced MR Imaging of Liver Tumors in HBV Transgenic Mice ...... 1464 Vito Lorusso, Luigi Miragoli, Linda Chaabane, Achille Iolascon, Daniela Spano, Vittorio Di Maso, Claudio Tiribelli, Fulvio Uggeri

Quantitative 3D Molecular Imaging of Kidney Glomeruli...... 1465 David H. Frakes, Arius Elvikis, Jonathan Plasencia, Scott Beeman, Kevin M. Bennett

Early in Vivo Manganese-Enhanced MRI (MEMRI) Detection of Embryonic Stem Cell Induced Teratoma Formation ...... 1466 Jaehoon Chung, Joelle K. Barral, Irv Weissman, Robert C.Rrobbins, Phillip C. Yang

Characterization of Single Wall Carbon Nanotubes as Anysotropic Contrast Agents for MRI...... 1467 Pilar Lopez-Larrubia, Viviana Negri, Laura Nieto-Charques, Sebastian Cerdan, Paloma Ballesteros

Detection and Characterization of Europium Based PARACEST Contrast Agents...... 1468 Heather H. Cornnell, Arthur S. Edison, Glenn A. Walter

Synthesis, Characterization and Application of Citrate Modified Superparamagetic Iron Oxide Nanoaparticles as a New Contrast Agent for Magnetic Resonance Imaging ...... 1469 Sachchidanand Srivastava, Rishi Awasthi, Namdeo Sri Ram Gajbhiye, Vikas Agarwal, Amit Singh, Rakesh K. Gupta

Novel Two Step PAMAM Dendrimers for Targeted MRI of TfR Expression...... 1470 Cesar A. Berrios-Otero, Steven Isaacman, Ben B. Bartelle, Kamila U. Szulc, James Canary, Daniel H. Turnbull

REACTION: Release Activation of Iron Oxide Nanoparticles: A Novel Environmentally Sensitive MRI Paradigm...... 1471 Dorit Granot, Erik M. Shapiro

Using MagA and Modified Ferritin Subunits to Track Tumor Cell Growth ...... 1472 Donna E. Goldhawk, Rene Figueredo, Claude Lemaire, Paula Foster, Savita Dhanvantari, Jim Koropatnick, R Terry Thompson, Frank S. Prato

Combined Imaging and Delivery of SiRNA to Pancreatic Islets...... 1473 Zdravka Medarova, Mohanraja Kumar, Shu-wing Ng, Junzheng Yang, Natasha Barteneva, Natalia Evgenov, Victoria Petkova, Anna Moore

Synthesis and Characterization of Novel Triple-Layer Nanoparticles with Multimodal Potential-First Results...... 1474 Zdravka Medarova, Mehmet Yigit, Chongzhao Ran, Mohanraja Kumar, Anna Moore

In Vivo Detection of Lymphatic Delivery of Liposomes Using DIACEST MRI Labeling ...... 1475 Guanshu Liu, Yah-el Har-el, Chris Long, Assaf A. Gilad, George Sgouros, Jeff W.M. Bulte, Peter C.M. van Zijl, Michael T. McMahon

Multimodal Thermo-Sensitive Polymer-Modified Liposome for Visualization and Treatment of Disseminated Cancer...... 1476 Daisuke Kokuryo, Hiroyuki Yoshida, Kenji Kono, Iwao Kanno, Ichio Aoki

Comparison of Neutral and Charged High Density Lipoprotein Using Bimodal Nanoparticles ...... 1477 Torjus Skajaa, Stefanie Jacoba Cornelia Geertruda Hectors, David P. Cormode, Nazila Kamaly, Andrew D. Miller, Wei Chen, Alessandra Barazza, Edward A. Fisher, Zahi A. Fayad, Willem J.M. Mulder

Molecular MRI and Fluorescence Imaging of Atherosclerosis Using Annexin A5-Functionalized Bimodal Nanoparticles ...... 1478 Geralda A.F. van Tilborg, Esad Vucic, Gustav J. Strijkers, David P. Cormode, Venkatesh Mani, Torjus Skajaa, Chris P.M. Reutelingsperger, Zahi A. Fayad, Willem J.M. Mulder, Klaas Nicolay

A Macrophage Specific Nanoparticle Suitable for Magnetic Resonance, Fluorescence, and Magnetic Particle Imaging ...... 1479 Willem J.M. Mulder, Torjus Skajaa, David P. Cormode, Hans Boeve, Zahi A. Fayad

New Fluorinated Gd-AspGlyMe-DOTA Complexes for 19F-MRI ...... 1480 Markus Plaumann, Ekkehard Küstermann, Dieter Leibfritz

Phase Gradient Mapping (PGM) for Positive Contrast Generation ...... 1481 Sunbok Lee, Jason Langley, Wei Liu, Qun Zhao

In Vivo Off Resonance Saturation Magnetic Resonance Imaging of ανβ3-Targeted Superparamagnetic Nanoparticles ...... 1482 Chalermchai Khemtong, Chase W. Kessinger, Jimin Ren, Erik A. Bey, Su-Geun Yang, Jagadeesh Setti Guthi, David A. Boothman, A Dean Sherry, Jinming Gao

Quantitative Ocular Pharmacokinetics Study in Rabbit Using T1 Mapping...... 1483 Xianfeng Shi, Xin Liu, Xueming Wu, Zhengrong Lu, Kevin Li, EunKee Jeong

Estimating Amounts of Iron Oxide from Gradient Echo Images ...... 1484 W Thomas Dixon, Daniel J. Blezek, Lisa A. Lowery, Dan E. Meyer, Amit M. Kulkarni, Brian C. Bales, Danielle L. Petko, Thomas K. Foo

In Vivo Assessment of the Number of Iron-Labeled Cells Using T2 Quantification...... 1485 Jean-Christophe Brisset, Virginie Desestret, Sebastien Marcellino, Emilie Devillard, Fabien Chauveau, Florence Lagarde, Serge Nataf, Norbert Nighoghossian, Yves Berthezene, Marlene Wiart

Dual Contrast Method for Cellular MRI Using Positive and Negative Contrast Agents...... 1486 Young Beom Kim, Seung-Schik Yoo, Ki Hyun Bae, Tae Gwan Park, HyunWook Park

* Gadonanotubes as a Dual Modal T1 and T2 MRI Contrast Agent: Magnetic Property Characterization by SQUID Magnetometry...... 1487 Michael L. Matson, Lon J. Wilson

Detection Limits of Very Small Iron Oxide Nanoparticles in Labeled Cells: A Quantitative Evaluation of Histochemistry and MR-Relaxometry ...... 1488 Gert Klug, Johannes Bremicker, Thomas Kampf, Elisabeth Bauer, Thomas Basse-Lüsebrink, Meike Weber, Uwe Gbureck, Ulrich Nöth, Peter Michael Jakob, Wolfgang Rudolf Bauer

* R2 Quantification of High Iron Concentrations for Cellular Therapy Applications with TurboSPI...... 1489 James A. Rioux, Steven D. Beyea, Chris V. Bowen

Direct Detection of SPIO Labeled Stem Cells ...... 1490 Martin Andreas Rückert, Thomas Kampf, Walter H. Kullmann, Peter M. Jakob, Volker Christian Behr

Increased CNR in On-Resonance PARACEST Imaging ...... 1491 Craig K . Jones, Alex Li, Ravi S. Menon, Robert Bartha

Design of a Novel, MRI-Compatible Bioreactor for Longitudinal Monitoring of Mechanically Conditioned Engineered Cardiovascular Constructs ...... 1492 Sharan Ramaswamy, Steven Boronyak, Margot Goldberg, Paul Schornack, Michael Sacks

Two-Compartment Pharmacokinetic Modeling of Targeted Molecular MRI Contrast Agents...... 1493 Marlies Oostendorp, Kim Douma, Tilman M. Hackeng, Marc A.M.J. van Zandvoort, Mark J. Post, Walter H. Backes

Laser Ablation ICP MS Imaging for the Detection of Contrast Agents in Tumour Tissue: Correlation to MR Images ...... 1494 Tammy Kalber, John Pugh, Nazila Kamaly, Jose Bunch, Jimmy Bell, Andrew Miller, Cameron McLeod

In Vivo Evaluation of the Specificity of Novel Drugs Targeting Dopamine D3 Receptors Using MRI: Role of Positive and Negative Hemodynamic Indices...... 1495 Ji-Kyung Choi, Joseph B. Mandeville, Y. Iris Chen, Peter Grundt, Amy H. Newman, Bruce G. Jenkins

Coupling 18F-Deoxyglucose PET Imaging and MRS at 14T of the in Vivo GLUT8 Knockout Mouse Brain...... 1496 Carole Lynn Poitry-Yamate, Bernard Lanz, Hongxia Lei, Frederic Prietner, Stephane Germain, Bernard Thorens, Rolf Gruetter

Imaging of SPIO Labelled Endothelial Networks at 3, 7 and 11.7 Tesla ...... 1497 Clemens Diwoky, Andreas Reinisch, Dieter Gross, Volker Lehmann, Dirk Strunk, Rudolf Stollberger

Complete Clearance of Iron Oxide from Intracerebrally Transplanted, Proliferating Neural Stem Cells ...... 1498 Piotr Walczak, Martijn L.L Chatrou, Luc W.E Starmans, Assaf A. Gilad, Klaas Nicolay, Jeff W.M Bulte

19F MRI and C-Arm CT Guiding of Reporter Probe Injection to Microencapsulated Mesenchymal Stem Cells for in Vivo Cell Viability Assessment with Bioluminescence Imaging ...... 1499 Dorota A. Kedziorek, Piotr Walczak, Yingli Fu, Tina Ehtiati, Alexander B. Brost, Nicole Azene, Gary Huang, Jeff W.M. Bulte, Steven M. Shea, Robert Krieg, Ronald Ouwerkerk, Frank K. Wacker, Dara L. Kraitchman

In Vivo Monitoring of Transplanted Human Embryonic Stem Cell-Derived Oligodendroglial Progenitors in a Mouse Model of Multiple Sclerosis...... 1500 Jaeyun Kim, Dian R. Arifin, Naser Muja, Assaf A. Gilad, Taeho Kim, Aravind Arepally, Taeghwan Hyeon, Jeff WM Bulte

Microfabrication of Multifunctional Alginate Capsule-in-Capsule (CIC) for Immunoprotected Cell Transplantation with MR, CT, and US Visibility...... 1501 J. Kim, D. R. Arifin, N. Muja, A. A. Gilad, T. Kim, A. Arepally, T. Hyeon, J. W. Bulte

Evaluation of Nanoparticle Contrast Agent Uptake in Murine Microglia (Bv-2) and Human Teracarcinoma (NT2) for Cell Tracking in Neurodegenerative Disease at 21.1 T ...... 1502 Jens Thorvald Rosenberg, Joshua M. Kogot, Chris Ridel, Geoffery F. Strouse, Samuel C. Grant

Iron Oxide Labeling of Mesenchymal Stem Cells with Micrometer-Sized Particles: Applications to Cartilage Tissue Engineering ...... 1503 Karl Saldanha, Ryan Doan, Sharmila Majumdar

Efficient Labeling of Dendritic Cells with a Clinical Applicable Perfluorpolyether Compound for Quantitative 19F MRI Tracking in Cancer Patients ...... 1504 Fernando José Bonetto, Mangala Srinivas, Arend Heerschap, Robbie Mailliard, Eric T. Ahrens, Carl Figdor, Jolanda de Vries

In Vivo MR Imaging of the Recruitment of Iron Oxide–labeled Macrophages in Renal Ischemic-Reperfusion Model in Mice...... 1505 Quan-Yu Cai, Hyo-Eun Park, Hyeyoung Moon, Kwan Soo Hong

Migration Dynamics of Neural Progenitor Cells Revealed by MRI ...... 1506 Brian John Nieman, Jeffrey Y. Shyu, Joe J. Rodriguez, Daniel H. Turnbull

Single Cell Tracking of Neural Progenitors Labeled in Vivo with Micron Sized Particles of Iron Oxide (MPIO) Into Specific Layers of the Olfactory Bulb ...... 1507 James P. Sumner, Stephen Dodd, Elizabeth Wayne, Der-Yow Chen, Yun Chen, Dragan Maric, Alan P. Koretsky

Inflammation Imaging of Atherosclerosis: MRI of Iron Oxide-Labelled Macrophages Trafficking in ApoE2 (KI) Mice Lesions...... 1508 Amine Bessaad, Monica Sigovan, Hasan Alsaid, Genviève De Souza, Nicolas Provost, Zoher Majd, Christine Menager, Norbert Nighoghossian, Serge Nataf, Emmanuelle Canet-Soulas

Cellular MR Imaging of Immune Cells Infiltration as a Marker for Assessment Allograft Outcome in a Chronic Cardiac Allograft Rejection Rat Model ...... 1509 Qing Ye, Yijen Lin Wu, Lesley M. Foley, T K. Hitchens, Hao Sen Zhang, Danielle Eytan, Chih Lung Chen, Chien Ho

In Vivo Differentiation of Magnetically Labeled Mesenchymal Stem Cells Into Hepatocytes for Cell Therapy to Repair Damaged Liver...... 1510 Shenghong Ju, Gao-jun Teng, Haihua Lu

Serial Monitoring and Quantification of Endogenous Neuroblast Migration Rates by Cellular MRI ...... 1511 Dorit Granot, Dustin Scheinost, Xenophon Papademetris, Erik M. Shapiro

Intravenous Injection of Fluorescent Iron-Oxide Nanoparticles for in Vivo Loading and Tracking of Monocytes to Myocardial Infarction by MRI and Optical Imaging...... 1512 Karin Montet-Abou, Jean-Luc Daire, Jean-Noel Hyacinthe, Francois Mach, Alke Petri-Fink, Heinrich Hofmann, Denis R. Morel, Jean-Paul Vallee, Xavier Montet

Comparison of Iron-Oxide- And Perfluorocarbon-Based Cellular Contrast Agents for Detecting Immune Cell Infiltration in Models of Organ Transplant Rejection...... 1513 T. Kevin Hitchens, Qing Ye, Danielle F. Eytan, Yijen L. Wu, Jelena M. Janjic, Eric T. Ahrens, Chien Ho

Using Ferritin as a Transgenic MRI Reporter for Monitoring of Embryonic Stem Cell Graft in Vivo ...... 1514 Hui Mao, Jun Liu, Eric C. Cheng, Rober C. Long, Shang Hsun Yang, Liya Wang, Pei Hsun Cheng, Jin Jing Yang, Anthony W.S. Chan

Evaluation of LV and AAV Vector Systems for Stable Delivery of MRI Reporter Genes to the Rodent Brain...... 1515 Greetje Vande Velde, Janaki Raman Rangarajan, Tom Dresselaers, Olga Krylyshkina, Abdelilah Ibrahimi, Zeger Debyser, Veerle Baekelandt, Uwe Himmelreich

MRI Reporter Gels to Detect Enzymes and Cells in Vivo ...... 1516 Jason Colomb, Ameya Jategaonkar, Kevin M. Bennett

Visualization of Patterned Gene Expression by MRI in the Anterior Zone of the Cerebellum ...... 1517 Hassan Marzban, Kamal Sahi, Vimal Prajapati, Mohammad Sabati, James N. Scott, Jeffrey F. Dunn, Richard Hawkes

MR Imaging of Gene Expression in Zebrafish...... 1518 Miriam Scadeng, Albert Kim, David Julian Dubowitz, Phil Hill, Nathan Gray, David Traver, Ellen Breen

Susceptibility Weighted Imaging Complements Diffusion Tensor Imaging in Traumatic Brain Injury...... 1519 Zhifeng Kou, Randall R. Benson, Ramtilak Gattu, E Mark Haacke

Comparison of MR Imaging Methods for Pre-Surgical Localisation of the Subthalamic Nucleus and Globus Pallidus...... 1520 Ruth L. O'Gorman, Stephen J. Wastling, Michelle Footman, David J. Lythgoe, Michael Samuel, Richard Selway, Keyoumars Ashkan, Jozef Jarosz

Optimal Parameters of Suppor Vector Machine for Classification of Multispectral Brain MRI...... 1521 Hsian-Min Chen, Jyh-Wen Chai, San-Kan Lee, Clayton Chi-Chang Chen, Ying-Cheng Lin, Yen-Chieh Ouyang, Chein-I Chang, Wu-Chung Shen

First Upright Study of CSF Flow in Chiari I Malformation with Cine Phase-Contrast MRI...... 1522 David Chu, Michael Boitano, Dan Culver, Raymond Damadian, Mary Gianni, Rob Viel, Jan Votruba, Robert Wolf

Identification of Traumatic Subarachnoid Hemorrhage Using Susceptibility Weighted Imaging...... 1523 Jing Lei, Zhen Wu, Meili Liu, Tong Han, Ewart Mark Haacke

Quantitative Susceptibility Imaging with Homotopic L0 Minimization Programming: Preliminary Study of Brain ...... 1524 Jing Liu, Tian Liu, Ludovic de Rochefort, Martin R. Prince, Yi R. Wang

MRI Estimation of Global Brain Oxygen Consumption Rate...... 1525 Varsha Jain, Michael Langham, Jeremy Magland, Felix Wehrli

MRI Derived Intracranial Compliance in Patients with Idiopathic Intracranial Hypertension...... 1526 Luca Nocetti, Alessandra Mantovani, Federica Tavani, Milena Cobelli, Stefano Vallone, Claudio Danielli, GianPietro Pinna

Compensating for Field Strength with Coils; Comparison of SNR at 1.5T, 3T and 7T with 12 and 32 Channel Arrays ...... 1527 Mattijs Elschot, Lawrence L. Wald, Stephan Biber, Michael Hamm, Christina Triantafyllou

Histological Validation of Hemorrhage and Temporal Blood Transformation Detected by Susceptibility Weighted Imaging in Traumatic Brain Injury ...... 1528 Zhifeng Kou, Yimin Shen, Nirsine Zakaria, Srini Kallak, John Cavanaugh, E Mark Haacke

Cross-Sectional Automatic Measurement of Brain Volume on MRI: Reproducibility of KNN-Based Probabilistic Segmentation...... 1529 Jeroen de Bresser, Cynthia Jongen, Petronella Anbeek, Max A. Viergever, L. J. Kappelle, G. J. Biessels

Magnetic Field Distortion Caused by Intracapillary Red Blood Cells ...... 1530 Toru Yamamoto, Osamu Tsuchida, T. Omatsu

The Allen Institute Mouse Brain Gene Expression Data Co-Aligned with a Mouse MRI Atlas...... 1531 Jason Philipp Lerch, Chris Lau, Lydia Ng, Michael Hawrylycz, R. Mark Henkelman

Anatomical Phenotyping of the Knockout Mouse Model of Fragile X Syndrome ...... 1532 Jacob Ellegood, Laura K. Pacey, David R. Hampson, Jason P. Lerch, R Mark Henkelman

High Resolution MRI of Enriched Environment Induced Structural Brain Changes ...... 1533 Ory Levy, Daniel M. Michaelson, Yaniv Assaf

MRI and 3D Visualization of Neurovascular Casts...... 1534 Jeff F. Dunn, Cheryl R. McCreary, Andre Obenaus, J Ross Mitchell

The Relationship Between Susceptibility Weighted Phase and White Matter Fiber Orientation ...... 1535 Enedino Hernández, Alex MacKay, Alexander Rauscher

Ultra High Resolution Venography Using T2* Weighted Imaging at 7T MRI...... 1536 Seo-Hyun Lee, Chang-Ki Kang, Chan-A Park, Seung-Taek Oh, Young-Bo Kim, Zang-Hee Cho

Understanding the Orientation Dependent T2* Contrast of the Cingulum in Ultra High Fields...... 1537 Andreas Schäfer, Christopher J. Wiggins, Robert Turner

Grey/white Matter Contrast in Phase Images: Is It Susceptibility or Is It Not?...... 1538 José Pedro Marques, Rolf Gruetter

Is R2* in Human Brain White Matter Dependent on B0 Orientation? ...... 1539 Tie-Qiang Li, Fukunaga Masaki, Stephen Dodd, Peter van Gelderen, Merkle Hellmut, Jeff H. Duyn

T1-Weighted MRI Visualizes Functional Anatomy in the Marmoset Cortex...... 1540 Nicholas A. Bock, Junjie Liu, Ara Kocharyan, Afonso C. Silva

Stochastic Analysis of Transverse Relaxation Caused by Local Field Inhomogeneities in Iron-Rich Brain Tissue...... 1541 John Frederic Schenck

Magnetic Resonance Imaging of Deep Brain Nuclei at 7 Tesla...... 1542 Adrienne Nicole Dula, E B. Welch, Robin G. Avison, John C. Gore, Malcolm J. Avison

Relaxation Times of Human Basal Ganglia Regions at 7 Tesla ...... 1543 Oliver Kraff, Jean-Jacques Lemaire, Jens M. Theysohn, Mark E. Ladd

Atlas-Based Analysis of Human Brainstem Anatomy as Revealed by Gradient-Echo T2 Weighted MR Imaging at 7T...... 1544 Fabrice Poupon, Dominique Hasboun, Linda Marrakchi, Eric Bardinet, Jean-François Mangin, Irina Kezele, Sarah Fernandez- Vidal, Kamil Ugurbil, Stéphane Lehericy, Cyril Poupon, Pierre-François van de Moortele, Jérôme Yelnik

3D Visualization of Deep Cerebellar Nuclei Using 7T MRI ...... 1545 Stefan Maderwald, Michael Küper, Markus Thürling, Kasja Rabe, Oliver Kraff, Elke G. Gizewski, Mark E. Ladd, Dagmar Timmann

In-Vivo Quantification of the Hippocampal Subfields Using 4.7T Fast Spin Echo Imaging...... 1546 Nikolai Vladimirovich Malykhin, Robert Marc Lebel, Nicholas J. Coupland, Rawle Carter, Peter Seres, Alan H. Wilman

Reliability Analysis of Hippocampal MRI Volumetry at 3 Tesla...... 1547 Jacobus F.A. Jansen, Cecile R. Jeukens, Marielle C. Vlooswijk, H J. Majoie, Marc C. de Krom, Albert P. Aldenkamp, Paul A. Hofman, Walter H. Backes

In-Vivo Rat Brain Tissue Characterization by Susceptibility Weighted Imaging at 9.4 T...... 1548 Nicoleta Baxan, Iulius Dragonu, Laura-Adela Harsan, Maxim Zaitsev, Jürgen Hennig, Dominik von Elverfeldt

A High-Resolution Quantitative Method for the Study of the Post Mortem Brain ...... 1549 Ana-Maria Oros-Peusquens, Fabian Keil, Miriam Rabea Kubach, N Jon Shah

Could We Characterize Fine Structures in Human Brain Using High-Resolution Magnitude and Phase Image at 7 Tesla in Vivo?...... 1550 Chan Hong Moon, Kyongtae Ty Ba

In Vivo Visualization of Cerebellar Cortical Layers Using Structural High Field MRI...... 1551 José Pedro Marques, Wietske van der Zwaag, Cristina Granziera, Gunnar Krueger, Rolf Gruetter

Morphometric MRI Analysis Based on High Resolution 3D Imaging at 7 Tesla Highlightes Focal Cortical Dysplasia in Epilepsy...... 1552 Oliver Speck, Claus Tempelmann, Julia Matzen, Hans-Jürgen Huppertz

Ultra-High Field Clinical Brain MR Imaging: Challenge and Excitement ...... 1553 William T.C. Yuh, Greg A. Christoforidis, Steffen Sammet, Petra Schmalbrock, Nina A. Mayr, John C. Grecula, Eric C. Bourekas, Jian Z. Wang, Jun Zhang, Michael V. Knopp

Ex Vivo Detection of Cerebral Amyloidosis on a Human 7 Tesla MRI System...... 1554 Sanneke van Rooden, Marion L.C. Maat-Schieman, Rob J.A. Nabuurs, Louise van der Weerd, Sjoerd G. van Duinen, Remco Natte, Mark A. van Buchem, Jeroen van der Grond

Parkinson’s Disease - Direct Visualization by 7.0T Brain Imaging...... 1555 Se-Hong Oh, B. Jeon, Jong-Min Kim, Kyung-Nam Kim, Sung-Yeon Park, Dae-Hyuk Kwon, Young-Bo Kim, Z. H. Cho

Extremely High Resolution, High Field Imaging of Brain Iron in an Iron-Storage Disease ...... 1556 John Frederic Schenck, Jeff H. Duyn, Peter van Gelderen, Hellmut Merkle, Arnulf E. Koeppen, Jiang Qian, Earl A. Zimmerman, John Cowan, David L. Henderson

High Resolution MRI of Xanthogranuloma of Choroid Plexus Induced by Hypercholesterolemia...... 1557 Yuanxin Chen, John A. Ronald, Hagen Kitzler, Andrew Alejski, Kem A. Rogers, Brian K. Rutt

A Study of Optimal Diffusion Indices to Differentiate Between Low and High Grade in Non-Enhancing Cerebral Gliomas and Neuronal- Glial Tumors...... 1558 Xiang Liu, Wei Tian, Sven Ekholm

Imaging of Brain Metastases of Bronchial Carcinoma with 7 Tesla MRI...... 1559 Christoph Moenninghoff, Stefan Maderwald, Philipp Schuett, Jens M. Theysohn, Oliver Kraff, Mark E. Ladd, Thomas Gauler, Michael Forsting, Isabel Wanke

Taurine – a Potential Natural Biomarker of Apoptosis in Gliomas ...... 1560 Kirstie S. Opstad, B Anthony Bell, John R. Griffiths, Franklyn A. Howe

Predicting Response to Anti-Angiogenic Chemotherapy in Patients with High-Grade Glioblastomas Using MR Perfusion Imaging ...... 1561 Rahul Sawlani, Jeffrey Raizer, Sandra W. Horowitz, Wanyong Shin, Sean A. Grimm, James P. Chandler, Robert Levy, Christopher C. Getch, Maulin Shah, Timothy J. Carroll

Multi-Source Feature Selection to Improve Multi-Class Brain Tumor Typing...... 1562 Vangelis Metsis, Dionyssios Mintzopoulos, Heng Huang, Michael N. Mindrinos, Peter M. Black, Filia Makedon, A Aria Tzika

Age-Filtered MRS Classifier to Overcome the Differences in Childhood and Adulthood Brain Tumours...... 1563 Javier Vicente, Juan Miguel García-Gómez, Salvador Tortajada, Elies Fuster-Garcia, Antoni Capdevila, Andrew Charles Peet, Bernardo Celda, Monserrat Robles

Detection of Glycine as a Biomarker of Malignancy in Childhood Brain Tumours Using In-Vivo 1H MRS at Short and Long TE...... 1564 Nigel Paul Davies, Martin Wilson, Kal Natarajan, Yu Sun, Shaheen Lateef, Lesley MacPherson, Marie-Anne Brundler, Theodorus N. Arvanitis, Richard G. Grundy, Andrew Charles Peet

Diagnosis of Brain Metastasis:Feasibility and Efficacy of Motion-Sensitized Driven-Equilibrium(MSDE) Turbo Spin-Echo Sequence ...... 1565 Eiki Nagao, Takashi Yoshiura, Akio Hiwatashi, Koji Yamashita, Hironori Kamano, Yukihisa Takayama, Osamu Togao, Makoto Obara, Tomoyuki Okuaki, Hiroshi Honda

DSC-MRI Measures of rCBV Predict Response to Bevacizumab Treatment More Reliably Than Standard MRI in Patients with Recurrent High-Grade Gliomas...... 1566 Kathleen M. Schmainda, Devyani Bedekar, Scott D. Rand, Jennifer Connelly, Shekar Kurpad, Hendrikus G. J. Krouwer, Eric S. Paulson, Mark G. Malkin

Evaluation of Treatment Response in Children with Brainstem Glioma by Correlating Cerebral Blood Flow Changes with Combined Vandetanib Administration and Local Radiation Therapy ...... 1567 Yong Zhang, Zoltan Patay, Ralf B. Loeffler, Ruitian Song, Alberto Broniscer, Claudia M. Hillenbrand

Subclassification of Brain Tumors Based on Ex Vivo MRS Metabolic Profiles...... 1568 Torill Eidhammer Sjøbakk, Sasha Gulati, Michel Gulati, Steinar Lundgren, Sverre Helge Torp, Ingrid Susann Gribbestad

Short Echo Time 1H Magnetic Resonance Spectroscopic Imaging in the Differentiation of High Grade Gliomas and Metastases in the Human Brain...... 1569 Jannie Petra Wijnen, Miriam W. Lagemaat, Patrick Krooshof, Albert J.S. Idema, Geert J. Postma, Lutgarde C.M. Buydens, Tom W.J. Scheenen, Arend Heerschap

"Brain Surface Motion Imaging" to Detect Adhesion Between Meningioma and Brain...... 1570 Toshiaki Taoka, Toshiaki Akashi, Toshiteru Miyasaka, Hiroyuki Nakagawa, Kaoru Myochin, Satoru Iwasaki, Kimihiko Kichikawa

MR Based Longitudinal Assessment of Pituitary Adenoma Growth Using Fully Automated Coregistration and Intensity Normalization ...... 1571 Kyrre E. Emblem, Dominic Holland, Geir Ringstad, John K. Hald, Anders M. Dale, Atle Bjornerud

Perilesional Area of Brain Tumors: A Longitudinal Diffusion Tensor Imaging Study ...... 1572 Kun-Hsien Chou, Hsuan-Hui Wang, Wan-You Guo, Ming-Tak Ho, Ming-Hsiung Chen, Woei-Chyn Chu, Ching-Po Lin

The Value of Two-Dimensional Gradient Echo Imaging (2D-GRE) and Susceptibility Weighted Imaging (SWI) in the Assessment of Hemorrhagic Lesions in Diffuse Brainstem Gliomas Treated with Radiation and Antiangiogenic Therapy...... 1573 Ulrike Löbel, Jan Sedlacik, Mehmet Kocak, Alberto Broniscer, Claudia M. Hillenbrand, Zoltán Patay

Accurate T1 and T2 Maps Obtained with IR-TrueFISP Calibrated by a Patient Driven Model...... 1574 Ralf Berthold Loeffler, Song Wu, Nicole van Groningen, Zoltan Patay, John O. Glass, Matthew P. Smeltzer, Claudia Maria Hillenbrand

Differentiation of Oligodendroglial Genotypes Using Perfusion Weighted Imaging and Proton MR Spectroscopy...... 1575 Sanjeev Chawla, Sangeeta Chaudhary, Ali Nabavizadeh, Sumei Wang, Gurpreet S. Kapoor, Gocke Timothy, Donald M. O'Rourke, Elias R. Melhem, Harish Poptani

Brain Tumor Classification Using a Novel H1 HRMAS MRS Method and Robust Algorithmic Classifiers...... 1576 Dionyssios Mintzopoulos, Ovidiu C. Andronesi, Konstantinos D. Blekas, Loukas G. Astrakas, Peter M. Black, A. Aria Tzika

Serial Analysis of Imaging Parameters in Patients with Newly Diagnosed Glioblastoma Multiforme ...... 1577 Yan Li, Janine Lupo, Wei Bian, Jason C. Crane, Soonmee Cha, Susan Chang, Sarah Nelson

FID-Based T1-Weighted UTE Imaging of Human Brain at 3T ...... 1578 Yongxian Qian, Tiejun Zhao, Fernando E. Boada

Short Echo Time MR Spectroscopy of Brain Tumors: Grading of Cerebral Gliomas ...... 1579 Jan Weis, Patrik Ring, Tommie Olofsson, Francisco Ortiz-Nieto, Johan Wikström

Comparison Study of MR Perfusion Imaging and Diffusion Tensor Imaging in the Grading of Non-Enhancing Cerebral Gliomas...... 1580 Xiang Liu, Wei Tian, Sven Ekholm

Hybrid Functional Diffusion and Perfusion Maps for Evaluation of Gliomas...... 1581 Benjamin M. Ellingson, Devyani P. Bedekar, Mark G. Malkin, Scott D. Rand, Alastair Hoyt, Jennifer Connelly, Shekar N. Kurpad, Kathleen M. Schmainda

Improved rCBV Calculation with Leakage Correction and First Pass Extraction ...... 1582 Xintao Hu, Kelvin Wong, Pamela New, Stephen Wong

Diagnostic Value of Brain Functional Imaging in the Assessment of Intraaxial Tumors...... 1583 Jose Maria Mateos-Pérez, Juan Adan Guzmán de Villoria, Irina Vidal-Migallón, Manuel Desco

4 Year Longitudinal MRI Follow-Up and 1H Single Voxel MRS in 22 Patients with Oligodendroglial Tumors or Gliomatosis Treated with Temodal ...... 1584 Jean-Marc Constans, Gabriela Hossu, François Kauffmann, Weibei Dou, Su Ruan, François Rioult, Jean-Michel Derlon, Emanuelle Lechapt Zalcman, Myriam Bernaudin, Françoise Chapon, Samuel Valable, Patrick Courthéoux, Jean-Sebastien Guillamo

Combination of Diffusion and Perfusion for Multi-Parametric Treatment Response Mapping of Human High Grade Glioma...... 1585 Thomas L. Chenevert, Craig J. Galban, Daniel A. Hamstra, Christina I. Tsien, Larry R. Junck, Pia C. Sundgren, Charles R. Meyer, Marko K. Ivancevic, Thomas C. Kwee, Suzan E. Rohrer, Brian D. Ross

Residual Pituitary Adenomas After Surgical Treatment: Improved Depiction with Gadobenate Dimeglumine Compared to Gadopentetate Dimeglumine ...... 1586 Nicoletta Anzalone, Paolo Vezzulli, Elisa Scola, Piero Picozzi, Antonella Iadanza, Miles A. Kirchin

Automatic Identification of Radiation Necrosis in Resected GBM Patients Using Cost-Sensitive OC-SVM Classifier ...... 1587 Xintao Hu, Geoffrey Young, Stephen Wong, Kelvin Wong

Multicenter Intraindividual Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine in MRI of Brain Tumors at 3 Tesla ...... 1588 Zoran Rumboldt, Howard A. Rowley, Fred Steinberg, Joseph A. Maldjian, Jordi Ruscalleda, Lars Gustafsson, Stefano Bastianello

Method for Accurate Tumor Volume Estimation in the Brain Using Healthy Tissue Subtraction...... 1589 J.B.M. Warntjes, J. West, P. Lundberg

1H MRSI Detection of Elevated Total Creatine in Brain Cancer: A Cautionary Tale...... 1590 Dikoma C. Shungu, Xiangling Mao, Apostolos J. Tsiouris, Carl E. Johnson, Jonathan P. Dyke, Linda A. Heier, Joseph O. Comunale, John A. Boockvar, Susan C. Pannullo

Simultaneous MRS and PET of the Human Brain in Healthy and Brain Tumor Subjects...... 1591 Ovidiu Cristian Andronesi, Ciprian Catana, Heisoog Kim, Dominique Jennings, Nouha Salibi, Michael Hamm, Josef Pfeuffer, Elizabeth Gerstner, Tracy Batchelor, A. Gregory Sorensen

Comparison of Cytotoxic and Anti-Angiogenic Treatment Responses Using Functional Diffusion Maps in FLAIR Abnormal Regions...... 1592 Benjamin M. Ellingson, Mark G. Malkin, Scott D. Rand, Alastair Hoyt, Jennifer Connelly, Devyani P. Bedekar, Shekar N. Kurpad, Kathleen M. Schmainda

MRI Characterization of a Focal Rat Brain Necrosis Induced by Interlaced Microbeam Radiation Therapy ...... 1593 Raphael Serduc, Nicolas Pannetier, Audrey Bouchet, Thierry Brochard, Thomas Christen, Gilles Berruyer, Jean Laissue, Francois Esteve, Chantal Remy, Emmanuel Barbier, Alberto Bravin, Géraldine Le Duc, Elke Brauer

Assessment of Vascular Reactivity in Two Rat Brain Gliomas (C6 and RG2) by Blood Volume Fraction MRI During CO2 Challenge and Correlation to Mature Vessels ...... 1594 Benjamin Lemasson, Nicolas Pannetier, Thomas Christen, Jan Warnking, Alexandre Krainik, Régine Farion, Christoph Segebarth, Olivier Duchamp, Chantal Rémy, Emmanuel L. Barbier

Avastin Alone or Combined to Campto® Reduces Local Blood Oxygen Saturation in an Orthotopic Human Glioblastoma Model (U87-MG) in Nude Rats...... 1595 Benjamin Lemasson, Thomas Christen, Nicolas Pannetier, Régine Farion, Christoph Segebarth, Xavier Tizon, Peggy Provent, Philippe Genne, Emmanuel L. Barbier, Olivier Duchamp, Chantal Rémy

Evaluating Treatment Response of Tumors with Temporal Diffusion Spectroscopy: Preliminary Results...... 1596 Daniel C. Colvin, Mary E. Loveless, Mark D. Does, Zou Yue, Thomas E. Yankeelov, John C. Gore

1H MAS NMR Spectroscopy of Metabolites and Lipids During Cell Growth Arrest Induced by Cisplatin in Cultured Rat Glioma BT4C Cells...... 1597 Ladan Mirbahai, Martin Wilson, Christopher S. Shaw, Carmel McConville, Roger D.G Malcomson, Risto A. Kauppinen, Andrew C. Peet

1H MRS Detected Mobile Lipids in Rodent Gliomas: Correlation with EPR Determined Tumour Oxygenation ...... 1598 S K. Hekmatyar, Timo Liimatainen, Neil Jerome, Nadeem Khan, Harold M. Swartz, Risto A. Kauppinen

MRI Characteristics of Primitive Neuroectodermal Tumors (PNETs) in a Spontaneous JCV T-Antigen Transgenic Mouse Brain Tumor Model at 7 Tesla ...... 1599 Feroze B. Mohamed, Harvey Hensley, Luis Del Valle, Linda Knight, Chris Conklin, Kamal Khalili, Scott H. Faro, Jennifer Gordon

High Resolution 13C HR-MAS Spectroscopy Analysis of Different Brain Regions from Rats Bearing C6 Implanted Gliomas ...... 1600 Valeria Righi, Pilar Lopez-Larrubia, Luisa Schenetti, Vitaliano Tugnoli, Maria-Luisa Garcia-Martin, Sebastian Cerdan

Long-Term Antipsychotic Treatment Does Not Alter MRS Measures of Metabolite Levels in Normal Rat Brain ...... 1601 Diana M. Lindquist, R S. Dunn, Brian Zappia

Cerebral Activation by Fasting Induces Lactate Accumulation in the Hypothalamus ...... 1602 Inês R. Violante, Jelena Anastasovska, Gina J. Sanchez-Canon, Tiago B. Rodrigues, Valeria Righi, Laura Nieto-Charques, James RC Parkinson, Stephen R. Bloom, Jimmy D. Bell, Sebastián Cerdán

Seizures Induced by Chronic Pentylenetetrazol Treatment Result in Progressive Neuronal Injuries in Rat Hippocampus: An in Vivo 1H MRS Study ...... 1603 Fang Fang, Hao Lei

Acute Retigabine Administration Reduces Level of Glutamate in Rat Hippocampus...... 1604 Renuka Sriram, Robert J. Mather, Richard L. Harris, Anne Burkholder, Serguei Liachenko

Tracking the Limbic-Frontal Glutamate System Associated with Aged Emotion Regulation...... 1605 Wei Chen, Elizabeth Rouse, David Olson, Jean A. King

Chronic Stress Hormone Treatment Reduces Glutamine Levels in the Hippocampus- An In Vivo MR Spectroscopy Study in Rats at 7T ...... 1606 Mirjam I. Schubert, Simon Beckett, Clare Spicer, Charles A. Marsden, Dorothee P. Auer

New Insights Into Mouse Brain Maturation as Assessed by 1H MRS at 7 Tesla...... 1607 Benjamin Schmitt, Catherine Amara, Ingo von Both, Peter Bachert, Andreas Schulze

Creatine Deficiency, Uptake and Breakdown Studied in Brain and Muscle of Arginine:Glycine Amidinotransferase Deficient Mice ...... 1608 Christine Nabuurs, Martijn Romeijn, Andor Veltien, Hermien Kan, Dirk Isbrandt, Arend Heerschap

Longitudinal 1H MRS of Hamster Superior Colliculus Following Retinotectal Deafferentation...... 1609 Kevin C. Chan, Yu-Xiang Liang, Rutledge G. Ellis-Behnke, Kwok-fai So, Ed X. Wu

1H-[13C] MRS Ex Vivo Study of Cortical Ketone Body Utilization in Awake Rats During Fasting-Induced Ketosis ...... 1610 Golam M.I. Chowdhury, Robin A. de Graaf, Lihong Jiang, Graeme F. Mason, Douglas L. Rothman, Kevin L. Behar

Deep Thiopental Anesthesia Alters Glucose Homeostasis But Not the Neurochemical Profile in Rat Cortex ...... 1611 Hongxia Lei, Joao MN Duarte, Vladmir Mlynarik, Agathe Python, Rolf Gruetter

Investigation of Temperature Dependence of Time-Of-Death Estimation Based on 1H-MRS Measurements in Sheep Heads ...... 1612 Michael Ith, Eva Scheurer, Roland Kreis, Michael Thali, Richard Dirnhofer, Chris Boesch

In Vivo Proton MRS Changes in Geriatric Rhesus Monkey Brain: Similarities to Human Alzheimer's Disease ...... 1613 RoseAnn Blenman-Abange, Richard Baumgartner, Marie Holahan, Jacquelynn Cook, Richard Hargreaves, Donald Williams

The Brain Ethanol Binding Potential and Its Effect on the Ethanol 1H Methyl MRS Amplitude ...... 1614 Graham S. Flory, Kathleen A. Grant, Christopher D. Kroenke

Metabolite T2 Mapping in the Healthy Rhesus Macaque Brain at 3 T...... 1615 Songtao Liu, Oded Gonen, Lazar Fleysher, Roman Fleysher, Brian Soher, Chan-Gyu Joo, Eva-Maria Ratai, R. Gilberto González

Improvement of Ammonia Removal by Glutamine Synthesis Is Associated with Attenuation of Encephalopathy in Acute Liver Failure: Protective Effects of the NMDA Receptor Antagonist Memantine...... 1616 Jessica Heins, Weinlei Jiang, Sven Gottschalk, Dieter Leibfritz, Roger F. Butterworth, Claudia Zwingmann

Metabolic Changes Detected by in Vivo Proton Magnetic Resonance Spectroscopy in the Striatum of Rats Treated with Alteration of Dietary Sulfur Amino Acids Content ...... 1617 Li Wei, Youngjia Park, Dean P. Jones, Xiaoping Hu

Indirect Generation of 13C-Hyperpolarized Choline and Lecithin Using Parahydrogen ...... 1618 Joachim Bargon, Ute Bommerich, Achim Koch, Kerstin Münnemann, Rahim R. Rizi, Meike Roth, Hans Wolfgang Spiess

Hemodynamic Scaling of fMRI-BOLD Signal Amplitude in Normal Aging...... 1619 Sridhar S. Kannurpatti, Michael A. Motes, Bart Rypma, Bharat B. Biswal

Age-Related Differences in fMRI During Weighted Arm Lifting...... 1620 Joo-hyun Kim, Huijin Song, Jae-jun Lee, Seung-tae Woo, In-sung Kim, Moon-jung Hwang, Young-ju Lee, Yongmin Chang

White Matter Integrity and Cognitive Ageing: A Combined Diffusion Tensor and Magnetization Transfer MRI Study ...... 1621 Mark E. Bastin, Lars Penke, Catherine Murray, Susana Muñoz Maniega, Maria Valdes Hernandez, Alan Gow, Joanna M. Wardlaw, Ian J. Deary

Diffusion Tensor Imaging of Creativity in Normal Human Subjects...... 1622 Rex E. Jung, Arvind Caprihan, Robert S. Chavez, Ranee A. Flores, Richard J. Haier

Fiber Tractography in Healthy Adolescents: An Automated Approach ...... 1623 Ryan L. Muetzel, Paul F. Collins, Bryon A. Mueller, Kelvin O. Lim, Monica Luciana

Comparison of Neighborhood Tractography Methods for Segmenting White Matter Tracts in the Ageing Brain...... 1624 Mark E. Bastin, Susana Muñoz Maniega, Jonathan D. Clayden, Amos J. Storkey, Laura J. E. Brown, Alasdair M J MacLullich

Brain Aging Patterns with ADC Histogram Analysis: A Large Scale and Wide Age Range Retrospective Study (767 Subjects, 15 Days-93.8 Years)...... 1625 Osamu Sakai, Steven Kussman, Al Ozonoff, Koji Tanabe, Kaan Erbay, Memi Watanabe, Naoko Saito, Hernan Jara

Whole-Brain N-Acetylaspartate Concentration Comparison of Young and Elderly Healthy: Evidence for Brain Durability ...... 1626 William E. Wu, Oded Gonen, Juchen Hirsch, Lutz Achtnichts, Katherine Weir, Andreas U. Monsch, Achim Gass

Metabolic Profiling of the Posterior Cingulate Gyrus in Healthy Adults: A 1H MRS Study ...... 1627 Sarah Andrea Wijtenburg, Kathleen L. Fuchs, Virginia I. Simnad, Jack Knight-Scott

Concentration Changes of Vitamin C and GSH in the Human Brain as Function of Age ...... 1628 Uzay Emrah Emir, Susan Raatz, Carolyn Torkelson, Tonya White, Susuan McPherson, Pierre-Gilles Henry, Melissa Terpstra

Posterior Cingulate Metabolic Profile at Ultra-High Field Indicates Decreased Anti-Oxidative Capacity with Aging...... 1629 Mary Charlotte Stephenson, Antonio Napolitano, Maryam Abaei, Mirjam I. Schubert, Peter Gordon Morris, Dorothee P. Auer

MCMxxxVI (1936): A New Versatile Automatic Technique for Brain Lesion Segmentation and Volume Analysis ...... 1630 Maria Valdes Hernandez, Mark E. Bastin, Joanna M. Wardlaw

Volumetric Measurement of Multispectral Brain MRI : Based on Independent Component Analysis and Support Vector Machine...... 1631 Clayton Chi-Chang Chen, Jyh-Wen Chai, San-Kan Lee, Yen-Chieh Ouyang, Chein-I Chang, Wu-Chung Shen, Hsian-Min Chen

Morphometry of the Corpus Callosum: Comparing Male Orchestral Musicians and Non-Musicians ...... 1632 Vanessa A. Sluming, Ihssan Adeeb Abdul-Kareem, Marta Garcia-Finana, Patricia E. Cowell

Sex Differences in the Neuroanatomy of Human Mirror-Neuron System: A T1- VBM Investigation...... 1633 Kun-Hsien Chou, I-Yun Chen, Pei-Chin Chen, Ya-Wei Cheng, Jean Decety, Ching-Po Lin

The Menopause May Be Associated with Hippocampal Volume Reduction...... 1634 Masami Goto, Osamu Abe, Sachiko Inano, Tosiaki Miyati, Naoto Hayashi, Shigeki Aoki, Harushi Mori, Hiroyuki Kabasawa, Kenji Ino, Keiichi Yano, Kyouhito Iida, Kazuo Mima, Kuni Ohtomo

DIR Imaging Using Compressed Sensing for Cortical Thickness Estimation...... 1635 Sung-Min Gho, Eung-Yeop Kim, Hahnsung Kim, Dong-Hyun Kim

Quantifying Typical Cortical Thickness Development in Children...... 1636 David C. Carver, Qing Ji, John O. Glass, Deqing Pei, Wilburn E. Reddick

Is B1-Correction for Neuroanatomy Necessary? ...... 1637 Jeff Gunter, Gregory Preboske, Chad Ward, Prashanthi Vemuri, Matt Bernstein, Clifford Jack Jr.

Simulation of MRI Related Tissue Changes Occurring during Formaldehyde Fixation of Human Brain Hemispheres...... 1638 Robert J. Dawe, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis

Slower Transverse Relaxation in the Dominant Hemisphere...... 1639 Jianli Wang, James R. Connor, Qing X. Yang

Temporal Progression of Thalamic Plaques in Alzheimer’s Disease Transgenic Mice (TAS10, TPM, TASTPM) – Comparison of MRI and µCT……………………………………………………………………………………………………………………………...1640 Andreas Pohlmann, Fatima Alarakhia, Brian P. Hayes, Victor Musoko, Marion J. Perren, D Ceri Davies, Michael F. James

The Effects of Genotype and Age on Fractional Anisotropy and Learning in an Alzheimer's Mouse Model...... 1641 Jason C. Pych, Alice M. Wyrwicz

Perfusion and Diffusion Imaging in a Mouse Model of Alzheimer's Disease ...... 1642 Eric Raymond Muir, Jeromy Dooyema, Lary C. Walker, James J. Lah, Timothy Q. Duong

Monitoring Therapy in a Triple Transgene Model of Alzheimer's DIsease Using MRS, Histology and Behavioral Correlations...... 1643 Bruce G. Jenkins, Ji-Kyung Choi, Alpaslan G. Dedeoglu

Deformation Based Morphometry in a Rodent Model of Parkinson's Disease...... 1644 Anthony Christopher Vernon, Saga Johansson, William R. Crum, Michel Modo

Progressive Neuroanatomical Changes in the YAC128 Mouse Model of Huntington’s Disease...... 1645 Jason Philipp Lerch, Jeffrey B. Carroll, Matthijs van Eede, Michael R. Hayden, R. Mark Henkelman

MRI and MRSI Characterization of the Quinolinic Acid Lesion Model of Huntington's Disease Over 49 Days: Persistence of Low Apparent Diffusion Coefficients and Spontaneous Recovery of N-Acetyl Aspartate Levels...... 1646 Noam Shemesh, Ofer Sadan, Eldad Melamed, Daniel Offen, Yoram Cohen

Intracellular pH Is a Promising Biomarker of Early Neurodegeneration, as Shown by 31P MRS in a 3-NP Rodent Model of Huntington's Disease...... 1647 Myriam Marianne Chaumeil, Celine Baligand, Emmanuel Brouillet, Philippe Hantraye, Pierre Carlier, Vincent Lebon

Reduced T2 Reveal Therapeutic Effect of the Antioxidant Vitamin E in the G93ASOD1 Mouse Model of ALS ...... 1648 Selina Bucher, Heiko G. Niessen, Thomas Kaulisch, Michael Neumaier, Albert C. Ludolph, Detlef Stiller

Diffusion Tensor Imaging of ALS-PDC at 21.1 T: in Utero Vs ex Utero Exposure...... 1649 Timothy Michael Gould, Jens Throvald Rosenberg, Ihssan Sabri Masad, Yemi Banjo, Christopher A. Shaw, Samuel Colles Grant

Increases in Creatine Detected by MRS Utilizing a Macaque Model of NeuroAIDS Suggests Glial Activation and Inflammation...... 1650 Eva-Maria Ratai, Jeffrey Bombardier, Chan-Gyu Joo, Julian He, Lakshman Annamalai, Susan V. Westmoreland, Tricia H. Burdo, Jennifer H. Campbell, Caroline Soulas, Kenneth Williams, R. Gilberto Gonzalez

7 Tesla MR Spectroscopy Reveals That CD8 T Lymphocyte Depletion Alone Has No Effect on Brain Metabolite Concentrations Confirming the Accelerated Rhesus Macaque Model of NeuroAIDS...... 1651 Eva-Maria Ratai, Sarah Pilkenton, Jeffrey Bombardier, Chan-Gyu Joo, Katherine W. Turk, Margaret R. Lentz, Julian He, Lakshman Annamalai, Shawn O' Neil, Susan V. Westmoreland, Tricia H. Burdo, Jennifer H. Campbell, Caroline Soulas, Patrick Autissier, Woong-Ki Kim, Kenneth Williams, R. Gilberto Gonzalez

Viral Burden and AIDS-Related Neurodegeneration: The Role of Blood and Cerebrospinal Fluid...... 1652 Jeffrey P. Bombardier, Eva-Maria Ratai, Chan Gyu Joo, Jeffrey D. Lifson, Michael Piatak, Jr, Elkan Halpern, Susan V. Westmoreland, Lakshmanan Annamalai, Kenneth Williams, Ramon Gilberto Gonzalez

Short-Echo-Time 1H MRS of the Mouse Lacking Prion Protein (Prnp-/-) at 14.1T...... 1653 Cristina Cudalbu, Vladimir Mlynárik, Juliane Bremer, Adriano Aguzzi, Rolf Gruetter

Novel Treatment Strategy in Mouse Model of Maple Syrup Urine Disease ...... 1654 William J. Zinnanti, Jelena Lazovic, John Flanagan

Diffusion Tensor Imaging of Rat Model of Obsessive-Compulsive Disorder...... 1655 Michael Dagan, Oded Klavir, Lior Brimberg, Daphna Joel, Yaniv Assaf

Using MRI to Quantify Optic Nerve Injury in Monkeys with Experimental Glaucoma: Atrophy and Diffusivity Effects...... 1656 Alexandre Coimbra, Miller Ogidigben, Robert Peiffer, Lynn O'Neil-Davis, Marie Holahan, Jacquelynn Cook, Donald Williams

Histological Confirmation of the Bilateral Effect of Unilateral Nerve Injury Detected by 2H NMR ...... 1657 Tal Ben-David, Galit Saar, Hadassah Shinar, Gil Navon

Long Term Effects of Recurrent Hyperglycemia on Hippocampal Neurochemistry in Developing Rats ...... 1658 Ivan Tkac, Kathleen Ennis, Raghavendra Rao

MRI Reveals Brain Asymmetry Following 6-OHDA Lesions in the Mouse Brain ...... 1659 Stephen J. Sawiak, Nigel I. Wood, G B. Williams, A J. Morton, T A. Carpenter

S. aureus Abscess Development in a Murine Model Measured Using MR Relaxometry and Diffusion Tensor Imaging ...... 1660 Michael Douglas Boska, Mariano Uberti, Amy Aldrich, Erin McIntyre, Tammy Kielian

Evidence that Exposure to Escalating Doses of Vaporized Alcohol Causes Increase in the Concentration of Choline-Containing Compounds in the Basal Ganglia of the Rat ...... 1661 Dirk Mayer, Natalie M. Zahr, Juan Orduna, Edith V. Sullivan, Adolf Pfefferbaum

Binge Ethanol Induced Structural and Neurochemical Changes in the Rat Brain Detectable at 3T ...... 1662 Natalie May Zahr, Dirk Mayer, Torsten Rohlfing, Michael Hasak, Oliver Hsu, Shara Vinco, Juan Orduna, Edith V. Sullivan, Adolf Pfefferbaum

Short-Echo-Time 1H MRS Studies of Alcohol Exposure on the Mouse Brain Over-Expressing Glutamate Dehydrogenase...... 1663 Wen-Tung Wang, Sang-Pil Lee, Elias Michaelis, In-Young Choi

Diffusion Tensor Imaging Supports the Cytotoxic Origin of Brain Edema in Experimental Hepatic Encephalopathy ...... 1664 Laia Chavarria, Marc Oria, Juli Alonso, Juan Córdoba, Silvia Lope-Piedrafita

A Volumetric Analysis of the Adult Zebra Finch Brain After Single and Repetitive Ecstasy Exposure ...... 1665 Parastou Foroutan, Susanne L. T. Cappendijk, Samuel C. Grant,

Effect of Long-Term Caffeine Consumption on Glucose Transport and Osmolarity Alterations in the Hippocampus of STZ-Induced and Goto-Kakizaki Diabetic Rats: in Vivo1H MRS Study at 9.4 T ...... 1666 João M. N. Duarte, Rui A. Carvalho, Rodrigo A. Cunha, Rolf Gruetter

An Investigation Into Young and Aged Rat Brain Volume Differences by Optimized Voxel-Based Morphometry...... 1667 Ronan Kelly, Laurence O' Dwyer, Eric O' Hanlon, Colm Connolly, Marina Lynch, Christian Kerskens

SPMMouse: A New Toolbox for SPM in the Animal Brain ...... 1668 Stephen J. Sawiak, Nigel I. Wood, G B. Williams, A J. Morton, T A. Carpenter

Comparison of Quantitative MT and T2 Properties of White Matter Lesions in Alzheimer's Disease ...... 1669 Kimberly L. Desmond, Greg J. Stanisz, Wendy Oakden, Nancy Lobaugh

Comparing MRI and CSF Biomarkers in Alzheimer’s Disease: Intergroup Discrimination and Predicting Clinical Change ...... 1670 Prashanthi Vemuri, Heather J. Wiste, Stephen D. Weigand, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Ronald C. Petersen, Clifford R. Jack Jr

In Vivo Localized Two Dimensional MR Spectroscopy to Compare the Neurochemical Profile in Wild-Type and Transgenic Mouse Model of Alzheimer’s Disease...... 1671 Niels Braakman, Firat Kara, Mark A. van Buchem, Reinhard Schliebs, Huub J.M. de Groot, A Alia

In Vivo and Post-Mortem Detection of Amyloid Plaques with a Non-Specific Gadolinium Contrast Agent ...... 1672 Alexandra Emmanuelle Petiet, Anne Bertrand, Christopher J. Wiggins, Diane Houitte, Thomas Debeir, Thomas Rooney, Marc Dhenain

Direct Visualization of ß-Amyloid Plaques in Alzheimer’s Disease Brain Tissue Using Clinical Field Strength MRI ...... 1673 Hagen H. Kitzler, John A. Ronald, Yuanxin Chen, Robert R. Hammond, Brian K. Rutt

Early Detection of Amyloid Plaques in a Transgenic Mouse Model of Alzheimer's Disease...... 1674 Ryan Chamberlain, Stephen D. Weigand, Malgorzata Marjanska, Denise Reyes, Tom M. Wengenack, Gregory Preboske, Angela Snyder, Geoffry L. Curran, Christine O'Brien, Joseph F. Poduslo, Michael Garwood, Clifford R. Jack

Regional Shape Changes of the Striatum and Thalamus in Alzheimer's Disease; a Morphometrical MRI Study...... 1675 Laura Willemijn de Jong, Luca Ferrarini, Jeroen van der Grond, Julien Milles, E.L.E.M Bollen, Rudy Westendorp, H Middelkoop, J. Reiber, Mark van Buchem

Multiple MRI Measures in the Characterization of Patients with Early Alzheimer Disease or Mild Cognitive Impairment - Relative Sparing of the Occipital Lobes...... 1676 Achim Gass, Steven Smith, Jochen Hirsch, Michael Amann, Matthias Guenther, Brandon Whitcher, Michael Chappell, Anil Rao, Mark Woolrich, Mark Sollberger, Markus Herdener, Paul M. Matthews, Andreas U. Monsch

Characterizing White Matter Disruption in Alzheimer Disease Patients ...... 1677 Xin Fan, Kristin Martin-Cook, Myron F. Weiner, Hao Huang

DTI Characteristics of Amnestic and Non-Amnestic Mild Cognitive Impairment ...... 1678 Kejal Kantarci, Ramesh T. Avula, Ali R. Samikoglu, Maria M. Shiung, Scott A. Przybelski, Stephen D. Weigand, Heidi A. Ward, Prashanthi Vemuri, David S. Knopman, Bradley F. Boeve, Ronald C. Petersen, Clifford R. Jack Jr.

Diffusion Tensor Imaging Characteristics of Dementia with Lewy Bodies and Alzheimer’s Disease ...... 1679 Kejal Kantarci, Ramesh T. Avula, Ali R. Samikoglu, Maria M. Shiung, Scott A. Przybelski, Stephen D. Weigand, Heidi A. Ward, Prashanthi Vemuri, David S. Knopman, Bradley F. Boeve, Ronald C. Petersen, Clifford R. Jack Jr.

Selection of Appropriate Fractional Anisotropy (FA) Threshold for Tract Based Diffusion Tensor Analysis of Uncinate Fascicles in Alzheimer Disease...... 1680 Toshiaki Taoka, Toshiaki Akashi, Toshiteru Miyasaka, Hiroyuki Nakagawa, Kaoru Myochin, Satoru Iwasaki, Kimihiko Kichikawa

Evaluation of Fibers in Limbic Circuits by Tract-Specific Diffusion Tensor Analysis. -Accessing Severity of Alzheimer Disease...... 1681 Toshiaki Taoka, Toshiaki Akashi, Toshiteru Miyasaka, Hiroyuki Nakagawa, Kaoru Myochin, Satorum Iwasaki, Kimihiko Kichikawa

Decreased Granger Causality Strength Between the Right and Left Hippocampal Network in Patients with Alzheimer Disease...... 1682 Guangyu Chen, Wenjun Li, Chunming Xie, Piero Antuono, Shi-Jiang Li

Global ROI-Based Functional Connectivity MRI (fcMRI) Analysis for Classification of Alzheimer’s Disease ...... 1683 Shi-Jiang Li, Barney Douglas Ward, Piero Antuono, Zhilin Wu, Jennifer Jones, Mei-Jie Zhang

Detection of Changes in Functional Connectivity MRI (fcMRI) Following Aricept® Treatment in Subjects with Mild Alzheimer’s Disease ...... 1684 Shi-Jiang Li, Barney Douglas Ward, Piero Antuono, Zhilin Wu, Jennifer Jones, Thomas McRae

Diagnosis of Alzheimer's Disease: Combined ASL Blood Flow Measurement and Morphometric Imaging ...... 1685 Takashi Yoshiura, Akio Hiwatashi, Koji Yamashita, Eiki Nagao, Hironori Kamano, Yukihisa Takayama, Osamu Togao, Tuvshinjargal Dashjamts, Tomoyuki Noguchi, Ivan Zimine, Tomoyuki Okuaki, Hiroshi Honda

Cerebrovascular Disease Associated White Matter Changes in Alzheimer’s Disease...... 1686 Liya Wang, Felicia C. Goldstein, Longchuan Li, James J. Lah, Allan I. Levey, Hui Mao

Enhanced Regional CBF in Patients with Mild Alzheimer’s Disease After Three Months of Aricept® Treatment ...... 1687 Wenjun Li, Chunming Xie, Zhilin Wu, Jennifer Jones, Piero Antuono, Thomas McRae, Shi-Jiang Li

White Matter Abnormality in Dementia with Lewy Bodies: A Diffusion Tensor Imaging Study ...... 1688 Kuniaki Kiuchi, Masayuki Morikawa, Toshiaki Taoka, Soichiro Kitamura, Tomohisa Nagashima, Kazumichi Hashimoto, Jun Kosaka, Yuichiro Inoue, Makoto Inoue, Kimihiko Kichikawa, Toshifumi Kishimoto

Identifying Cerebrovascular Versus Parenchymal Disease Components in Dementia with Rest-Stress CASL MRI...... 1689 Georg Deutsch, David G. Clark, Amol Pednekar, Beverly Corbitt, Jan den Hollander

Arterial Spin Labeling in the Identification of Abnormal Perfusion Patterns in Early, Drug-Naïve Parkinson's Disease...... 1690 Tracy Robert Melzer, Richard Watts, Michael R. MacAskill, Ross Keenan, Ajit Shankaranarayanan, David C. Alsop, Charlotte Graham, Leslie Livingston, John C. Dalrymple-Alford, Tim J. Anderson

A DTI Analysis of Limbic System Structural Integrity and Global Cognitive Status in Parkinson’s Disease...... 1691 Tracy Robert Melzer, Richard Watts, Michael R. MacAskill, Ross Keenan, Charlotte Graham, Leslie Livingston, John C. Dalrymple-Alford, Tim J. Anderson

Increased Cerebral Grey Matter Volume and Density in Early Parkinson's Disease...... 1692 Hong Yang, Yi-Lei Zhao, Jun-Feng Xu, Xu-Ning Zheng, Dong-qiang Liu, Min-ming Zhang

Preliminary Study of the Brain in Patients with Amyotrophic Lateral Sclerosis by Using Susceptibility-Weighted Imaging ...... 1693 Lin Ma, Mengyu Liu

Diffusion Tensor Imaging in Sporadic and Familial (D90A SOD1) Forms of Amyotrophic Lateral Sclerosis...... 1694 Biba Stanton, Daisy Shinhmar, Vicky Williams, Camilla Blain, Martin Turner, Vincent Giampietro, Marco Catani, Steve Williams, Nigel Leigh, P M. Andersen, Andy Simmons

High-Resolution Longitudinal Voxel-Based Morphometric Study in ALS ...... 1695 Don Charles Bigler, Yaman Aksu, Helen E. Stephens, Jeffrey Vesek, Kevin R. Scott, Claire Flaherty-Craig, Jianli Wang, Paul J. Eslinger, Zachary Simmons, Qing X. Yang

Elevated Myo-Inositol Reflects Activation of Astroglia and Microglia in Cognitive Impaired HIV Patients ...... 1696 Ute Feger, Mary Ricardo- Dukelow, Thomas Ernst, Vivek Nerurkar, Esther Volper, Steve Buchthal, Helenna Nakama, Linda Chang

Factor Analysis of Proton MR Spectroscopic Imaging Data in HIV Infection: Regional Patterns of Involvement and Relationship to Cognitive Status ...... 1697 Mona Adel Mohamed, Margaret R. Lentz, Vallent Lee, Mahaveer Degaonkar, Elkan Halpern, Ned Sacktor, Peter B. Barker, Martin G. Pomper

Abnormal T2’ Relaxation Rates as a Measure of Iron Concentration in HIVPositive Subjects...... 1698 Eric Keith Baxter, Linda Chang, Thomas Ernst, Victor Andrew Stenger

Increased Brain Diffusion Detected Using DWI-MR in Cats Infected with Feline Immunodeficiency Virus...... 1699 Susan Kraft, Susan VandeWoude, Dan Bucy, Mark Brown, Annette Bachand, Lisbeth Sestina, Helle Bielefeldt-Ohmann, John Elder

Neuronal Metabolism in HIV+ Subjects Lacking Immune Control Correlates to M-CSF Levels in Cerebrospinal Fluid ...... 1700 Margaret R. Lentz, Mona A. Mohamed, Mahaveer N. Degaonkar, Hyun Kim, Elkan Halpern, Ned Sacktor, Katherine Conant, Peter B. Barker, Martin G. Pomper

NAA Factor Scores Suggest Neuronal Recovery During Antiretroviral Therapy: an MRSI Study ...... 1701 Margaret R. Lentz, Mona A. Mohamed, Mahaveer N. Degaonkar, Vallent Lee, Hyun Kim, Elkan Halpern, Ned Sacktor, Ola Selnes, Peter B. Barker, Martin G. Pomper

Dynamic Contrast Enhanced (DCE) Perfusion Indices as a Measure of Blood Brain Barrier (BBB) Disruption in Different Stages of Neurocysticercosis ...... 1702 Rishi Awasthi, Avantika Verma, Vimal Kumar Paliwal, Sanjay Kumar Verma, Kashi Nath Prasad, Ram Kishore Singh Rathore, Rakesh K. Gupta

Volumetric Assessment of Type-1 Diabetic Neural Atrophy Using Voxel Based Morphometry ...... 1703 Nyssa Elaine Craig, Rajiv Gandhi, Dinesh Selvarajah, Kar Ping Kuet, Sudheer Lankappa, Solomon Tesfaye, Iain David Wilkinson

Parallel Neurochemical Alterations as Measured by High Field MRS in Patients and Mice with Spinocerebellar Ataxia Type 1 (SCA1) ...... 1704 Gulin Oz, Diane Hutter, Ivan Tkac, Harry T. Orr, Khalaf Bushara, Christopher M. Gomez

Measurement of Disease Severity in Niemann-Pick Disease Type C Using 3T MRS ...... 1705 Eva H. Baker, Nicole M. Yanjanin, Andrea L. Gropman, Forbes D. Porter

Measurement of Metabolite T2 at 3T in Niemann-Pick Disease Type C ...... 1706 Eva H. Baker, Nicole M. Yanjanin, Andrea L. Gropman, Forbes D. Porter

Longitudinal Study of Metabolite Levels in Niemann-Pick Disease Type C ...... 1707 Eva H. Baker, Nicole M. Yanjanin, Andrea L. Gropman, Forbes D. Porter

Basal Ganglia NAA/Cr Ratio in Gulf War Syndrome at 3T ...... 1708 Sergey Cheshkov, Audrey Chang, Hyeonman Baek, Richard Briggs, Robert Haley

Cerebral Metabolism in Obstructive Sleep Apnea: An In-Vivo Proton MRS Study ...... 1709 S K. Sharma, Sanjeev Sinha, Uma Sharma, Karikanni Kalathil A. Danishad, H Sharma, H K. Misra, H Misra, T Kathiravan, V V. Reddy, Vishnubhatla Sreenivas, S S. Kumaran, Naranamangalam R. Jagannathan

Dynamic Changes in Brain Bioenergetics During Apneic Excursions in Obstructive Sleep Apnea...... 1710 Caroline Rae, Delwyn Bartlett, Qiao Yang, David Walton, Angela Denotti, Toos Sachinwalla, Ron R. Grunstein

Combining fMRI with QMRS for Understanding the Etiology of Periodic Hypersomnia...... 1711 Anders Tisell, Maria Engström, Olof Dahlqvist Leinhard, Thomas Karlsson, Patrick Vigren, Anne Marie Landtblom, Peter Lundberg

Thalamic and Caudate Hypertrophy in Recovery from Critical Illness...... 1712 Max Louis Gunther, William R. Riddle, Alessandro Morandi, Michael Hooper, E Wesley Ely, Christopher Cannistraci, Whit Schrader, Kristen L. Merkle, John Chris Gatenby, John C. Gore

Noninvasive Quantification of Human Brain Antioxidant Concentrations Via Double Edited 1H MRS Throughout Intravenous Delivery of Vitamin C ...... 1713 Melissa Terpstra, Carolyn Torkelson, Susan Raatz, Tonya White, Kamil Ugurbil, Ivan Tkac

The Regional Changes of Non-BBB Pituitary Perfusion Characteristics in Idiopathic Growth Hormone Deficiency Patients by Dynamic Contrast Enhanced T1 MR Imaging: Assess by Brix Pharmaceutical Model...... 1714 Chao-Ying Wang, Hua-San Liu, Chun-Jung Juan, Hsiao-Wen Chung, Nei-Yu Chuo, Ming-Chung Chou, Cheng-Yu Chen

Impact of Depression on Cerebral Glutamate and Cognitive Function in Abstinent Methamphetamine Users (AMU) ...... 1715 Osama Abulseoud, Napapon Sailasuta, Martha Hernandez, Brian Ross

Quantitative Susceptibility Imaging of the Rat Brain Using a Dedicated Setup Allowing Different Orientations Along B0 ...... 1716 Ludovic de Rochefort, Tian Liu, Martine Guillemiller, Diane Houitte, Yi Wang, Philippe Hantraye, Vincent Lebon

Optic Radiation DTI Measures of White Matter Integrity Inversely Correlate with Visual Acuity in MS ...... 1717 Robert A. Bermel, Jian Lin, Ken Sakaie, Natasha Frost, Jeffrey A. Cohen, Mark J. Lowe, Micheal D. Phillips

Utility of Tract Based Spatial Statistics (TBSS) to Discriminate Subgroups of Multiple Sclerosis Patients ...... 1718 Jochen G. Hirsch, Yvonne Naegelin, Michael Amann, Pascal Kuster, Stefan Traud, Kerstin Bendfeldt, Ernst Wilhelm Radue, Ludwig Kappos, Achim Gass

In-Vivo Quantitative Measure of Black Hole Severity in Multiple Sclerosis with Gradient Echo Plural Contrast Imaging ...... 1719 Pascal Sati, Anne H. Cross, Dmitriy A. Yablonskiy

Improved Correlation of Composite MRI Scores with EDSS in Multiple Sclerosis...... 1720 Aziz Hatim Poonawalla, Sushmita Datta, Vaibhav Juneja, Flavia Nelson, Jerry Wolinsky, Gary Cutter, Ponnada Narayana

DESPOT: Application and Optimisation for postmortem Multiple Sclerosis Brain...... 1721 Klaus Schmierer, Sean CL Deoni, Declan Chard, David H. Miller, Claudia AM Wheeler-Kingshott

Quantifying Optic Nerve Atrophy in MS: A Motion Insensitive Technique for the Anterior Portion of the Optic Nerve ...... 1722 Marios C. Yiannakas, Claudia Wheeler-Kingshott, Alaine M. Berry, Karyn Chappell, David H. Miller, Daniel J. Tozer

Advantages of Gradient Echo Plural Contrast Imaging for Identifying MS Abnormalities in Postmortem Brain Tissue ...... 1723 Pascal Sati, Anne H. Cross, Robert E. Schmidt, Dmitriy A. Yablonskiy

Correlation of Metabolic and Diffusivity Markers in Multiple Sclerosis Using MR Spectroscopic Imaging and DTI ...... 1724 Dominic Sappey-Marinier, Matthieu Bagory, Salem Hannoun, Danielle Ibarrola, Jean-Christophe Comte, Francoise Durand- Dubief, Christian Confavreux

Longitudinal Imaging of Myelin Repair and Axonal Loss in Multiple Sclerosis ...... 1725 Robert J. Fox, Jian Lin, Thomas Cronin, Xiaofeng Wang, Ken Sakaie, Mark J. Lowe, Michael D. Phillips

Diversity of Cortical and Subcortical MS Pathology/Lesions Revealed by 7T MRI ...... 1726 Adrienne Nicole Dula, Siddharama Pawate, E B. Welch, Robin G. Avison, Subramaniam Sriram, Jeff L. Creasy, John C. Gore, Malcolm J. Avison

Quantification of Callosal Widths Using Conformal Mapping: Application to Multiple Sclerosis ...... 1727 Mehul Pravin Sampat, Pallavi Shashikant Jesrani, Dominik Meier, Annika M. Berger, Brian Healy, Peter Hildenbrand, Howard Weiner, Charles R.G. Guttmann

Prediction of Persistent and Transient T1 ‘black Holes’ in Multiple Sclerosis Using MRI Texture Analysis ...... 1728 Yunyan Zhang, Anthony Traboulsee, Yinshan Zhao, Luanne M. Metz, David KB Li

An Estimation of Method-Inherent and Pathology-Associated Variability of GM Measures in MS Using Dual Sampling ...... 1729 Jan Scholz, Tarunya Arun, Morgan Hough, Amy Dodd, Heidi Johansen-Berg, Jackie Palace

Brain Metabolites Proton T2 Mapping at 3 Tesla in Relapsing-Remitting Multiple Sclerosis ...... 1730 Ivan I. Kirov, Lazar Fleysher, Roman Fleysher, Songtao Liu, Joseph Herbert, Oded Gonen

Inverse Dependence Between Patient Population and Correlation of Composite MRI Scores with EDSS in Multiple Sclerosis ...... 1731 Aziz Hatim Poonawalla, Sushmita Datta, Vaibhav Juneja, Flavia Nelson, Jerry Wolinsky, Gary Cutter, Ponnada Narayana

In Vivo Measurements of Neural Stem and Progenitor Cells (NPCs) in Patients with Multiple Sclerosis and Normal Controls, Using MRS and LCModel ...... 1732 Claudiu Schirda, Christopher Magnano, E. Ann Yeh, Bianca Weinstock-Guttman, Allison S. Drake, Jennifer L. Cox, Robert Zivadinov

Comparison of Spectroscopic Imaging Vs. Localized Spectroscopy to Characterize Clinical Forms of Multiple...... 1733 Matthieu Bagory, Françoise Durand-dubief, Danielle Ibarrola, Jean-Christophe Comte, Christian Confavreux, Dominique Sappey- Marinier

High Field T1 Predicts Neuronal Loss in Multiple Sclerosis Cortical Grey Matter...... 1734 Klaus Schmierer, Po-Wah So, Shu F. An, Sebastian Brandner, David H. Miller, Tarek A. Yousry, Harold G. Parkes

An Evaluation of the Robustness of Tract-Based Measures of White Matter Integrity ...... 1735 Mingyi Li, Jian Lin, Ken Sakaie, Erik Beall, Lael Stone, Robert Bermel, Micheal D. Phillips, Mark J. Lowe

Automated Vs. Conventional Tractography in Multiple Sclerosis: Variability and Correlation with Disability ...... 1736 Daniel Salo Reich, Seth A. Smith, Arzu Ozturk, Eliza M. Gordon-Lipkin, Sheena K. Farrell, Peter C. M. van Zijl, Peter A. Calabresi, Susumu Mori

Comparison of 1.5 and 3.0 Tesla MRI Diffusion Tensor Imaging (DTI) in Patients with Multiple Sclerosis ...... 1737 Michael John Moser, Robert K. Breger, Bhupendra O. Khatri, Yu Liu

Gadofluorine M Enhanced MRI Reveals Circumventricular Organ Involvement in CNS Inflammation and Facilitates Occult Lesion Detection ...... 1738 Eva Tysiak, Jens Wuerfel

Measuring Perfusion and Permeability in Multiple Sclerosis: Dynamic Contrast-Enhanced MRI in 3D at 3T...... 1739 Michael Ingrisch, Dominik Morhard, Steven Sourbron, Lisa-Ann Gerdes, Tania Kümpfel, Reinhard Hohlfeld, Maximilian F. Reiser, Christian Glaser

In-Vivo Insights Into Magnetization Exchange in Human White Matter Structures ...... 1740 Saeed Kalantari, Cornelia Laule, Thorarin Albert Bjarnason, Alex Lloyd MacKay

Comparing 3T and 7T in the Detection of Small Parenchymal Blood Vessels in MS Lesions ...... 1741 Emma Clare Tallantyre, Jennifer E. Dixon, Paul S. Morgan, Matthew J. Brookes, Ali Al-Radaideh, Nikos Evangelou, Peter G. Morris

Optic Nerve Dedicated Magnetization Transfer and Diffusion Tensor Imaging Shows Correlation with Thickness of Retinal Nerve Fiber Layer Detected by Optical Coherence Tomography ...... 1742 Seth Aaron Smith, Zoe R. Williams, Daniel S. Reich, Jonathan AD Farrell, Sheena K. Farrell, John N. Ratchford, Peter CM van Zijl, Neil R. Miller, Peter A. Calabresi

Neural Progenitor Cell Distribution and White Matter Reorganization After Traumatic Brain Injury Measured by MRI and Histology ...... 1743 Quan Jiang, Guang Liang Ding, Siamak Pourabdollah-Nejad, Chang Sheng Qu, Asim Mahmood, Lian Li, Zheng Gang Zhang, Jia Ni Hu, Yi Ming Shen, Zhi Feng Kou, Hassan Bagher-Ebadian, James R. Ewing, Michael Chopp

The Contribution of Myelin to the T2 of Corpus Collosum in Shiverer Mouse...... 1744 Craig A. Branch, Victor V. Dyakin, Yuanxin Chen, V Veranna, A Kumar, C Peterhoff, Randolph Nixon

Multiexponential T2, Magnetization Transfer and Quantitative Histology in White Matter Tracts of Rat Spinal Cord ...... 1745 Adrienne N. Dula, Holly L. Valentine, William M. Valentine, Daniel F. Gochberg, Mark D. Does

Noninvasive Detection of Selective Vulnerability of Cerebral White Matter Tracts to Cuprizone ...... 1746 Mingqiang Xie, Regina C. Armstrong, Anne H. Cross, Sheng-Kwei Song

MRI Detectable Spinal Cord Atrophy Correlates with Disability in a Murine Model of Multiple Sclerosis ...... 1747 Istvan Pirko, Aaron J. Johnson, Anne K. Lohrey, Jun Ying, Diana Lindquist, R. Scott Dunn

DTI of a Mouse Model of Pelizaeus-Merzbacher Disease: Correlating MR Measures with Morphometric Analyses...... 1748 Torsten Ruest, Julia M. Edgar, William Matthew Holmes, Jennifer A. Barrie, Klaus A. Nave, Thomas J. Anderson, Debbie Dewar

Mapping White Matter Degradation Following Mild Traumatic Brain Injury: A Diffusion Tensor Imaging Study...... 1749 Wang Zhan, Grant Gauger, Gary Abrams, Tatjana Novakovic-Agopian, Michele Meeker, Lauren Boreta, Tess Kornfield, Yu Zhang, Marzieh Nezamzadeh, Norbert Schuff, Michael Weiner

Cerebral White Matter Recovery in Abstinent Alcoholics – a Multimodal Magnetic Resonance Study...... 1750 Anderson Mon, Stefan Gazdzinski, Timothy C. Durazzo, Ping Hong Yeh, Dieter J. Meyerhoff

Discrimination of Distinct Patterns of Myelin-Associated Parameters in Hypomyelinating White Matter Disorders by Multimodal Quantitative MR-Imaging...... 1751 Steffi Dreha-Kulaczewski, Knut Brockmann, Marco Henneke, Claudia Zuercher, Peter Dechent, Jutta Gaertner, Gunther Helms

Multi-Slide Proton MRSI and Clinical Outcome in Children with Late Infantile Metachromatic Leukodystrophy (MLD) ...... 1752 Christine i. Dali, Lars G. Hanson, Jens Fogh, Allan M. Lund

Diffusion Tensor Imaging in Tumefactive Demyelinating Lesions and High Grade Glioma:A Comparative Study...... 1753 Xiang Liu, Wei Tian, Sven Ekholm

Idiopathic Autoimmune Encephalopathy: MR Imaging Appearance...... 1754 Feng Feng, Jing Gao, Hui You, Ming-Li Li, Zheng-Yu Jin

Diffusion Tensor Imaging and 1H-MR Spectroscopy for Evaluation of Methotrexate Leukoencephalopathy in a Patient with Acute Lymphoblastic Leukemia ...... 1755 Ulrike Löbel, John O. Glass, Hiroto Inaba, Wilburn E. Reddick, John T. Sandlund, Zoltán Patay

UTE Imaging of White Matter Injury of Immaturity...... 1756 Ulrika E. Svanholm, Magnus Mårtensson, Brigitte Vollmer, Linda Holmström, Atsushi Takahashi, Bo Nordell, Olof Flodmark

Automated Quantification of White Matter Hyperintensity Burden Using MPRAGE and FLAIR Images from a Large Population ...... 1757 Keith Hulsey, Roderick McColl

Changes of MRSI and DTI Findings Following Traumatic Brain Injury ...... 1758 Andrew A. Maudsley, Varan Govind, Stuart Gold, Leo Harris, Jonathan Jagid, Krithica Kaliannan, Gaurev Saigal

A DTI Study of Structural Integrity of White Matter in Prader-Willi Syndrome ...... 1759 Tianyu Tang, Jennifer L. Miller, Karen M. von Deneen, Guojun He, Mark S. Gold, Daniel J. Driscoll, Yijun Liu

Group Analysis of Tractography Images Using Early Registration in Primary Dystonia Patients...... 1760 Aziz M. Ulug, Miklos Argyelan, Martin Niethammer, David Eidelberg

Diffusion Properties of Cortico-Striatal White Matter Tractography as Sensistive Markers of Parkinson's Disease...... 1761 Yonas Weldeselassie, Ghassan Hamarneh, Martin J. McKeown, Samantha Palmer, M. Stella Atkins

Diffusion Spectrum Imaging Tractography Study in Chronic Alcoholics Found Marked Deficit of White Matter Integrity in the Posterior Cingulate Cortex...... 1762 Cheng-Liang Liu, I-Chao Liu, Chih-Jui Chen, Wen-Yang Chiang, Fang-Cheng Yeh, Wen-Yih Isaac Tseng

Quantification of Fornix Tracts in MCI and AD...... 1763 Darryl Hwa Hwang, Sinchai Tsao, Manbir Singh

DTI Is Useful for Early Diagnosis of MSA, Separating from Parkinson’s Disease: Evidence for Subclinical Detection of Cerebellar Pathology...... 1764 Sung-Yeon Park, Se-Hong Oh, Chong-Sik Lee, Sang-Jun Kim, Jae-Seung Kim, Young-Bo Kim, Z.H. Cho

White Matter Integrity in Mild Cognitive Impairment and Alzheimer’s Disease: A Diffusion-Tensor Imaging Study ...... 1765 Claire E. Sexton, Clare Elizabeth Mackay, Mark E. Bastin, Jane Lonie, Klaus Peter Ebmeier

Diffusion Spectrum Imaging of White Matter Abnormalities in Fronto-Striato-Thalamic Circuit in Obsessive- Compulsive Disorder...... 1766 C-H. Chiu, Yu-Chun Lo, W-Y. Chiang, F-C. Yeh, W-Y. I. Tseng

Diffusion Tensor Fiber Tracking of Human Brain Connectivity to Localize Intractable Seizures in Epileptic Patients...... 1767 Cemil Kirbas, Robert Simkins, Phillip White, Roulla Hilli, Sudeepa Gupta Hall, Jason Parker

Evaluation for MTBI and DAI by Using Voxel-Based Diffusion Tensor Imaging ...... 1768 Kazumi Kasahara, Masahiro Abo, Keiji Hashimoto, Atsushi Senoo, Takashi Kodama

Neural Correlates of Spatial Awareness Revealed by MR DTI Tractography and Intraoperative Subcortical Mapping...... 1769 Antonella Castellano, Lorenzo Bello, Enrica Fava, Alessandra Casarotti, Costanza Papagno, Giorgio Carrabba, Giuseppe Scotti, Andrea Falini

Determination of Hand Motor Corticospinal Tract in Corona Radiata by Functional MRI and Diffusion Tensor Imaging ...... 1770 Cheol Pyo Hong, Sung Ho Jang, Dong Hoon Lee, Do Wan Lee, Bong Soo Han

Pre-Surgical Mapping of Paediatric Motor Function and Structure Using Magnetoencephalography (MEG) and Diffusion Tensor Imaging (DTI) ...... 1771 Donald Mabbott, Nadia Scantlebury, Conrad Rockel, Elysa Widjaja, William Gaetz

Probabilistic Tracking Can Improve the Delineation of Cortico-Spinal Tract for Neurosurgical Planning...... 1772 Maria Luisa Mandelli, Mitchel S. Berger, Jeffrey I. Berman, Bagrat Amirbekian, Elio C. Maccagnano, Roland G. Henry

White Matter Damage in End-Stage Renal Disease: Assessment with Diffusion-Tensor Imaging...... 1773 Tsyh-Jyi Hsieh, Twei-Shiun Jaw, Jer-Ming Chang, Hung-Yi Chuang, Chih-Hung Ko

Comparative Evaluation of Corpus Callosum Diffusion Tensor Imaging Metrics in Acute Mild and Moderate Traumatic Brain Injury (TBI): It’s Correlation with Neuropsychometric Tests (NPT)...... 1774 Rakesh K. Gupta, Raj Kumar, Mazhar Husain, Chaynika Chaudhry, Arti Srivastava, Sona Saksena, Ram K.S. Rathore

High Order Diffusion Imaging Used to Differentiate Cytotoxic and Vasogenic Edema in Humans ...... 1775 Chu-Yu Lee, Lina J. Karam, Josef P. Debbins

The Impact of Different HRFs in Simultaneous EEG/fMRI Studies in Epilepsy ...... 1776 Henrique Fernandes, Mario Forjaz Secca, Alberto Leal

BOLD EEG-fMRI of Focal Temporal Lobe Epilepsy...... 1777 Maurício S. Sercheli, Elizabeth Bilevicius, Helka Ozelo, Andréa Alessio, Fabricio RS Pereira, Jane M. Rondina, Tatiane Pedro, Fernando Cendes, Roberto JM Covolan

Simultaneous EEG-CBV (Electroencephalography – Cerebral Blood Volume) Measurements of Epileptic Spikes ...... 1778 Michiro Negishi, Maolin Qiu, Robert Todd Constable

Video-Based Monitoring for fMRI of Uncontrolled Motor Tasks...... 1779 Fred Tam, Dmitri Matenine, Vadim Bachmutsky, Simon J. Graham

Normalization of fMRI Signal Improves Group Differentiation in Alzheimer’s Disease ...... 1780 Uma Yezhuvath, Jinsoo Uh, Feng Xu, Rani Varghese, Kelly Lewis-Amezcua, Kristin Martin-Cook, Myron Weiner, Hanzhang Lu

Simulated Stuttering in Non-Stuttering Healthy Subjects: Differentiating Cause from Consequence in Developmental Stuttering ...... 1781 Catherine Theys, Stefan Sunaert, Silvia Kovacs, Astrid van Wieringen, Luc De Nil

Comparison of Motor Function and Cortical Activation in Parkinson’s Disease...... 1782 Micheal D. Phillips, Angela L. Ridgel, Jerrold L. Vitek, Katherine Koenig, Erik Beall, Mark Lowe, Jay L. Alberts

Reduction of R2* in the Basal Ganglia of Restless Legs Syndrome: A Biomarker for Iron Deficiency ...... 1783 Byeong-Yeul Lee, Elana Farace, Xiaoyu Sun, James R. Connor, Qing X. Yang

BOLD Signal Changes of Imaginary Walking Before and After Lumbar Puncture in NPH-Patients ...... 1784 Ekkehard Küstermann, Markus Ebke, Katja Dolge, Dieter Leibfritz, Manfred Herrmann

Comparison of Induced Motor Responses in fMRI and Intrinsic Motor Networks in ICA...... 1785 Andreas Weibull, Peter Mannfolk, Anders Björkman, Birgitta Rosén, Göran Lundborg, Johan Olsrud, Jonas Svensson

Can fMRI Replace Wada in Pre-Surgical Evaluation of Language Dominance? ...... 1786 Madalina Elena Tivarus, John T. Langfitt, Derek D. Lasher, Sven Ekholm

Brain Activation During Tongue Motor and Swallowing Tasks:A Functional MRI Study in Healthy Volunteers and Patients with Tongue Cancer...... 1787 Kyung K. Peck, Samantha Haupage, Ryan Branski, Andrei Holodny, Dennis Kraus

An Investigation of Intrinsic, Task-Interim Resting State BOLD Signal Correlations with Broca's and Wernicke's Areas in Schizophrenics and in Subjects at High Genetic Risk ...... 1788 Jeremy L. Smith, Xiaobo Li, Lynn DeLisi, Craig A. Branch

Altered Cortico-Striatal Functional Connectivity in Obsessive-Compulsive Disorder ...... 1789 Ben J. Harrison, Carles Soriano-Mas, Jesus Pujol, Hector Ortiz, Marina Lopez-Sola, Rosa Hernandez-Ribas, Joan Deus, Pino Alonso, Murat Yucel, Christos Pantelis, Jose Menchon, Narcis Cardoner

Functional Imaging of Welders with Occupational Manganese Exposure Using a Finger Tapping Task ...... 1790 Huijin Song, Jae-jun Lee, In-sung Kim, Joo-hyun Kim, Moon-jung Hwang, Young-ju Lee, Yangho Kim, Yongmin Chang

Effect of Acamprosate on Glutamate Level of Alcoholic Subjects...... 1791 Reza Momenan, John Umhau, Yan Zhang, Daniel Hommer, Markus Heilig, Jun Shen

Roles of Amygdala and Insula During Brain Activation with Dynamic Gastric Distention...... 1792 Dardo Tomasi, Gene-Jack Wang, Ruiliang L. Wang, Walter Backus, Frank Telang, Christopher Wong, Allan Geliebter, Joanna S. Fowler, Nora D. Volkow

Striatal Dopamine Correlates Working Memory Activation During Sleep Deprivation But Not During Rested Wakefulness: A PET-fMRI Study ...... 1793 Dardo Tomasi, Ruiliang L. Wang, Frank Telang, Vasilios Boronikolas, Millard C. Jayne, Gene-Jack Wang, Elisabeth C. Caparelli, Joanna S. Fowler, Nora D. Volkow

Functional Connectivity Differences to Ventral Putamen of Gulf War Syndrome II and Control Subjects...... 1794 Lei Jiang, Parina Gandhi, Mingguo Qui, Aman Goyal, Yan Fang, Luo Ouyang, Kaundinya Gopinath, Wendy Ringe, Robert Haley, Richard Briggs

High-Field MR Imaging Reveals an Acute Impact on Brain Function in Survivors of the Wenchuan Earthquake in China...... 1795 Su Lui, Xiaoqi Huang, Long Chen, Hehan Tang, Tijiang Zhang, Xiuli Li, Dongming Li, Ling Zou, Raymend C Chan, Andrea Mechelli, John A. Sweeney, Qiyong Gong

Adaptation of the Visual Cortex in Response to Cataract Surgery ...... 1796 Astrid Rosenstand Lou, Hanne Olsen Julian, Jan Ulrik Prause, Troels Wesenberg Kjær, Olaf B. Paulson, Kristoffer Hougaard Madsen

Volume 4

Brain Function Disruption of Thalamus Related Resting State Networks in Patients with Mild Traumatic Brain Injury ...... 1797 Lin Tang, Yulin Ge, Daniel K. Sodickson, Laura Miles, Joseph Reaume, Robert I. Grossman

A Novel MR-Compatible Hand Induced Robotic Device in Conjunction with fMRI Allows Accurate Brain Mapping...... 1798 Dionyssios Mintzopoulos, Azadeh Khanicheh, Loukas G. Astrakas, A Aria Tzika

A 1H MRS Study at 3.0 Tesla of the Anterior Cingulate Cortex in Patients with Borderline Personality Disorder and Healthy Controls ...... 1799 Mareen Hoerst, Wolfgang Weber-Fahr, Nuran Tunc-Skarka, Matthias Ruf, Christian Schmahl, Gabriele Ende

Absolute Quantification of Phosmomono- And Phosphodiesters in the Brain of Patients with Major Depression...... 1800 Wolfgang Weber-Fahr, Helga Wentzel, Traute Demirakca, Alexander Sartorius, Gabriele Ende

Test-Retest Reliability of Key Metabolite Measurements in the Anterior Cingulate Cortex Using Single Voxel 1H Press at 3T ...... 1801 Murat Yucel, R. M. Wellard, Ian Harding, Mike Kean, Nadia Solowij, Dan I. Lubman, Marc Seal, Alex Fornito, Stephen J. Wood, Christos Pantelis

Metabolite T2 Relaxation Abnormalities in Bipolar Disorder and Schizophrenia...... 1802 David P. Olson, J. Eric Jensen, Andrew P. Prescot, Elixabeth D. Rouse, Bruce M. Cohen, Perry F. Renshaw, Dost Öngür

Alterations of Excitatory Neurotransmitter Systems in Brain Regions of Acute Migraine Patients During the Interictal State...... 1803 Andrew Prescot, Lino Becerra, Gautam Pendse, Shannon Tully, Eric Jensen, Perry Renshaw, Rami Burstein, David Borsook

Disrupted White Matter Connectivity Revealed by Diffusion Tensor Imaging in Children with Tourette Syndrome...... 1804 Xiaoqi Huang, Jinhua Sun, Xiu Li Li, Fei Li, Mingjing Huang, Lanting Guo, Qiyong Gong

White Matter Abnormalities Detected in Very Early-Onset Bipolar Disoder ...... 1805 Melissa Lopez-Larson, Janine Terry, Deborah Yurgelun-Todd, David Kennedy, Jean Frazier

A DTI Tractography Study of the Cingulum in Euthymic Bipolar I Disorder...... 1806 Louise Emsell, Alexander Leemans, Camilla Langan, Gareth Barker, Wilhelm van der Putten, Peter McCarthy, Rachel Skinner, Colm McDonald, Dara M. Cannon

White Matter Structural Changes in High-Risk Major Depressive Disorder Youths Detected by Diffusion Tensor Images ...... 1807 Hao Huang, Xin Fan, Anup Bidesi, Uma Rao

Assessment of White Matter Integrity and Subregional Myelination in First-Episode Psychosis Patients Using Myelin Water Imaging...... 1808 Donna Jane-Mai Lang, Alex L. Mackay, Eugene Yip, Nicole Fitchner, Cornelia Laule, Bill MacEwan, Lili C. Kopala, William George Honer

A Diffusion Tensor MRI Study of White Matter Microstructure in Tardive Dyskinia: Relation to Symptoms...... 1809 Kun-Hsien Chou, I-Yun Chen, Ya-Mei Bai, Tung-Ping Su, Woei-Chyn Chu, Ching-Po Lin

Probabilistic Tractography in Patients with Schizophrenia...... 1810 Ryan L. Muetzel, Bryon A. Mueller, Jeffrey R. Wozniak, Christopher J. Bell, Kelvin O. Lim

Cortical Thickness in Patients with Major Depression and Healthy Volunteers...... 1811 Simon Fristed Eskildsen, Hanna Järnum, Lasse Riis Østergaard, Elena Steffensen, Elna-Marie Larsson

Differences of Cortical Thickness in Patients with Late-Life Depression Relative to Healthy Aging Measured Using MRI ...... 1812 Feng-Xian Yan, Shwu-Hua Lee, Han-Jung Ko, Ho-Ling Liu

Functional MRI Correlations in Women Diagnosed with Borderline Personality Disorder Exposed to Self-Harm Imagery...... 1813 Sudeepa Gupta Hall, Jerald Kay, Douglas Lehrer, Cemil Kirbas, Jason G. Parker

Structural Deficit in Remitted and Non-Remitted Recurrent Depression: A Voxel-Based Morphometric Study...... 1814 Pei-Chin Chen, Kun-Hsien Chou, I-Yun Chen, Hsuan-Hui Wang, Cheng-Ta Li, Tung-Ping Su, Ching-Po Lin

Diagnostic Classification with Neural Correlates of Verbal Fluency Distinguishes Schizophrenia from Bipolar Disorder and Healthy Individuals ...... 1815 Sergi G. Costafreda, Cynthia H.Y. Fu, Marco Picchioni, Timothea Toulopoulou, Fergus Kane, Sri Kalindindi, Colm McDonald, Janaina Mourao-Miranda, Eugenia Kravariti, Muriel Walshe, Nicolette Marshall, Diana Prata, Michael J. Brammer, Robin M. Murray, Philip K. McGuire

Reduced Cortical Gray Matter in Long-Term Abstinent Alcoholics ...... 1816 Ryan Shimotsu, Russell Chu, George Fein

Volume and Shape Analysis of the Caudate in ADHD Adults ...... 1817 Karlene M. Fraser, Ruth L. O'Gorman, Laura A. Wherity, Philip J. Asherson, Brian Toone, Mitul A. Mehta

Characterizing Structural MR Brain Changes of Child and Adolescent Bipolar Disorder Patients Using Random Forests Classification...... 1818 Ping-Hong Yeh, Hongtu Hongtu Zhu, Mark Nicoletti, Hasan Baloch, John Hatch, Giovana Zunta-Soares, Jair C. Soares

MRSI Study of Brain Lithium Followed by Missed Doses ...... 1819 Subbaraya Ramaprasad, Lindsay Rice, Melvin Lyon

GRAPPA-Accelerated High-Resolution Diffusion Tensor Imaging of Infants Without the Need for General Anesthesia...... 1820 Stefan Skare, Samantha Holdsworth, Kristen Yeom, Roland Bammer

T1-Weighted 3D SAP-EPI for Use in Pediatric Imaging Without General Anesthesia ...... 1821 Samantha J. Holdsworth, Stefan Skare, K Yeom, Roland Bammer

Automatic Segmentation of Brain Tissues for Newborn MRI in Longitudinal Study ...... 1822 Feng Shi, Yong Fan, Songyuan Tang, Katie Cleary, Martin Styner, John Gilmore, Weili Lin, Dinggang Shen

Hybrid Atlas Based Tissue Segmentation for Neonatal Brain MRI Acquired Using a Dedicated Phased Array Coil...... 1823 Feng Shi, Yong Fan, Jie-Zhi Cheng, Lawrence L. Wald, Guido Gerig, Weili Lin, Dinggang Shen

Structural Correlates of Fluid Reasoning Development Indexed by Diffusion Tensor Imaging and Cortical Thickness Analyses...... 1824 Kirstie Jane Whitaker, Elizabeth D. O'Hare, Zdea A. Op de Macks, Brian D. Johnson, Emilio Ferrer, Silvia A. Bunge

Developmental Increase of Diffusion Anisotropy in the Acoustic Radiations Measured by DTI Correlates with Maturational Shortening of Auditory Evoked Neuromagnetic Field Response Detected with Magnetoencephalography (MEG) ...... 1825 Timothy P.L. Roberts, Sarah Khan, Michael Rey, Justin Monroe, Michael Gandal, Katelyn Cannon, John Dell, Ralph Magee, J. Christopher Edgar, Deborah Zarnow

Brain Metabolite Changes in Infants Exposed in Utero to Methamphetamine And/or Nicotine...... 1826 Steven Buchthal, Thomas Ernst, Lynn M. Anderson, Christine Cloak, Riley Kitamura, Linda Chang

Elevated Working Memory Brain Activation in Adolescents with Early Childhood Lead Exposure...... 1827 Song Lai, Jianrong Shi, John P. Lackey, Jay S. Schneider

Clinical Assessment of Brain Perfusion in Newborn Infants with Arterial Spin Labeling Perfusion MRI...... 1828 Pia Wintermark, Josef Pfeuffer, Michael Hamm, Richard L. Robertson, Anne Hansen, Janet Soul, Simon K. Warfield

Use of a 32-Channel Coil to Improve Resolution in Assessing Brain Perfusion of Newborn Infants with 3T MRI ...... 1829 Pia Wintermark, Josef Pfeuffer, Michael Hamm, Christina Triantafyllou, Richard L. Robertson, Anne Hansen, Janet Soul, Simon K. Warfield

Prevalence of Fear in Young Children Towards the MRI Environment...... 1830 Krisztina Malisza, Toby Martin, Deborah Shiloff, Mary Malainey, Dickie Yu

3D PROspective MOtion Correction System (PROMO) in Pediatric Population ...... 1831 Mazyar E. Ahmadi, Timothy T. Brown, Joshua M. Kuperman, J C. Roddey, Nathen S. White, Ajit Shankaranarayanan, Eric Han, Dan Rettmann, Anders M. Dale

Investigating the Long-Term Effects of Preterm Birth on Brain Volume Development Using Voxel-Based Morphometry of MRI Data...... 1832 Zoltan Nagy, John Ashburner, Bogdan Drakanski, Hugo Lagercrantz

Investigating the Long-Term Effects of Preterm Birth on Brain White Matter Using Tract-Based Spatial Statistics and Fractional Anisotropy Data ...... 1833 Zoltan Nagy, Saad Jbabdi, Jesper Andersson, Stefan Skare, Hugo Lagercrantz

Corpus Callosum Development in the Preterm Infant: A DTI Study ...... 1834 Deanne Kim Thompson, Terrie E. Inder, Leigh Johnston, Nathan Faggian, Lex W. Doyle, Gary F. Egan

Abnormal White Matter and Gray Matter Maturation in Premature Neonates with Periventricular Hemorrhagic Infarction: A Diffusion Tensor Imaging Study ...... 1835 Ajay Garg, Jeffrey I. Berman, Duan Xu, Srivathsa Veeraraghavan, Sonia L. Bonifacio, Hannah Cranley Glass, Daniel B. Vigneron, Anthony James Barkovich, Pratik Mukherjee

Non-Invasive Estimation of Brain Deep Grey Matter Temperature Using Localised Proton Magnetic Resonance Spectroscopy in Normothermic and Hypothermic Newborn Infants...... 1836 Alan Bainbridge, Giles Kendall, Enrico DeVita, Cornelia Hagmann, Andrew Kapetanakis, Ernest Cady, Nicola Robertson

MR Spectroscopy of Premature Newborns ...... 1837 Duan Xu, Natalie Charlton, Shoujun Zhao, Ying Lu, Donna M. Ferriero, Daniel B. Vigneron, A James Barkovich

Could T1 and T2 Weighted Volumetric Imaging Be Used for Clinical Purposes in the Very Preterm Brain? ...... 1838 Revital Nossin-Manor, Manohar Shroff, Hilary Whyte, João Paulo Soares-Fernandes, Bejoy Thomas, Drew Morris, Margot Jane Taylor, John G. Sled

Rapid T1 Measurements in the Very Preterm Neonatal Brain at 1.5T...... 1839 Revital Nossin-Manor, Hai-Ling Margaret Cheng, Hilary Whyte, João Paulo Soares-Fernandes, Bejoy Thomas, Aideen M. Moore, Margot Jane Taylor, John G. Sled

Normobaric Hyperoximia Increases Cerebral Injury Caused by Perinatal Hypoxia: DTI Study in Rats ...... 1840 Kurt Hermann Bockhorst, Harriet Charmaine Rhea, Rui Liu, Jose Regino Perez-Polo, Ponnada A. Narayana

Effect of Recurrent Isoflurane Anaesthesia During Development on the Neurochemical Profile of the Frontal and Occipital Cortex of Adult Mice: An in Vivo 1H MRS Study at 14.1 T...... 1841 João MN Duarte, Anita Frank, Kim Q. Do, Rolf Gruetter

Do Maternally Produced Cytokines Contribute to Fetal Neuroinflammation? MR Perspectives...... 1842 Sylvie Girard, Luc Tremblay, Melanie Archambault, Guillaume Sebire, Martin Lepage

Quantitative Assessment of Prenatal X-Ray Exposure Using Longitudinal Gadolinium-, Manganese-Enhanced and Perfusion MRI in Neonatal Rats...... 1843 Shigeyoshi Saito, Kazuhiko Sawada, Xue-Zhi Sun, Tetsuya Suhara, Iwao Kanno, Ichio Aoki

Cortical and Sub-Cortical Networks in Children with Absence Epilepsy...... 1844 Patrick Carney, Danny Flannagan, David Abbott, Richard Masterton, Ingrid Scheffer, Simon Harvey, Sam Berkovic, Graeme Jackson

Analysis of fMRI Timecourse and Correlation in Typical Childhood Absence Seizures...... 1845 Xiaoxiao Bai, Matthew Vestal, Rachel Berman, Michiro Negishi, Edward Novotny, Todd Constable, Hal Blumenfeld

Phase Analysis of Neonatal Cerebral Venous System by Susceptibility-Weighted Magnetic Resonance Imaging...... 1846 Tetsu Niwa, Noriko Aida, Hiroshi Kawaguchi, Takayuki Obata, Ayako Shishikura, Tomio Inoue

Quantification of Fetal Brain Lactate with MR Spectroscopy...... 1847 Geoff Charles-Edwards, Wajanat Jan, Meekai To, Darryl Maxwell, Stephen Keevil, Richard Robinson

Morphology and Morphometry of the Cerebellum in Williams Syndrome: A T1-Weighted MRI Study ...... 1848 Margherita Di Paola, Deny Menghini, Riccardo Murri, Stefano Vicari, Laura Petrosini, Carlo Caltagirone

Reduced Caudate Nuclei Volumes in Patients with Congenital Central Hypoventilation Syndrome ...... 1849 Rajesh Kumar, Rebecca Ahdout, Paul M. Macey, Mary A. Woo, Ronald M. Harper

Mammillary Body Volume Loss in Patients with Congenital Central Hypoventilation Syndrome...... 1850 Rajesh Kumar, Kwanoo Lee, Paul M. Macey, Mary A. Woo, Ronald M. Harper

Shape Analysis on Subcortical Structures with Its Application in Children with Autism...... 1851 Anqi Qiu, Deana Crocetti, Michael I. Miller, Steward H. Mostofsky

Altered Brain Microstructure in Adolescents with ADHD: A Voxel-Based DKI Analysis...... 1852 Joseph A. Helpern, Vitria Adisetiyo, Adriana Di Martino, Maria F. Falangola, Anita Ramani, Caixia Hu, Kathleen A. Williams, Francisco X. Castellanos, Jens H. Jensen

Analysis of Superior Longitudinal Fasciculus and Arcuate Fasciculus with Diffusion Tensor Images of Dyslexia Patients...... 1853 Hao Huang, Jonathan M. Chia, Michael C. Morriss, Zhiyue J. Wang, Barjor Gimi, Nancy K. Rollins

Proton MRS Shows Cerebral Accumulation of Neurotoxic 3-Hydroxyisovaleric Acid in 3-Methylcrotonyl-CoA- Carboxylase Deficiency...... 1854 Marinette van der Graaf, Udo F.H. Engelke, Eva Morava, Maaike C. de Vries, Leo A.J. Kluijtmans, Bozena Góraj, Ron A. Wevers, Arend Heerschap

Multinational Phase III Clinical Trial of the Safety and Efficacy of Gadobenate Dimeglumine for Contrast- Enhanced MR Neuroimaging in Children...... 1855 Matthew J. Kuhn, Emilio Cianciulli, Claudio Fonda, Mieczyslaw Pasowicz, Pei-yi Gao

Gadobenate Dimeglumine for Contrast-Enhanced MRI of the Central Nervous System in Children ...... 1856 Cesare Colosimo, Mieczyslaw Pasowicz, Phillipe Demaerel, Paolo Tortori-Donati, Pei-yi Gao, Matthew J. Kuhn

Manganese - Gold Nanospheres as Positive Contrast Agents for Magnetic Resonance Imaging (MRI) ...... 1857 Stephanie Jacobs, Simona Murph, Matthew Siegfried, Steven Serkiz, Tom Chih-Chuang Hu

Structural Abnormalities Revealed by T2-Weighted and Manganese-Enhanced MRI in Methylazoxymethanol Acetate-Treated Rats: Relevance as a Translational Biomarker for Schizophrenia...... 1858 Chih-Liang Chin, Peter Curzon, Ann E. Tovcimak, Bryan F. Cox, Lynne E. Rueter, Michael W. Decker, Gerard B. Fox, Ana M. Basso

Modeling Cardiac Manganese Efflux Using T1-Mapping Manganese-Enhanced MRI in a Murine Model...... 1859 Benjamin Waghorn, Nathan Yanasak, Tom C.-C. Hu

Assessing Manganese Efflux Using SEA0400 and Cardiac T1-Mapping Manganese-Enhanced MRI in a Murine Model ...... 1860 Benjamin Waghorn, Yuhui Yang, Akemichi Baba, Toshio Matsuda, Nathan Yanasak, Tom C.-C. Hu

Mapping Nociceptive Pathways Using Activity-Dependent Manganese-Enhanced MRI ...... 1861 Pai-Feng Yang, Jyh-Horng Chen, Chen-Tung Yen

MEMRI Detects Axonal Degeneration Earlier Then DTI ...... 1862 Shu-Wei Sun

Effect of Dietary Composition on the Neuronal Activation Following Peripheral Injection of Cholecystokinin in Mice Detected by Manganese-Enhanced Magnetic Resonance Imaging ...... 1863 Nadine Zeeni, Nachiket A. Nadkarni, Jimmy D. Bell, Ralph Sinkus, Gilles Fromentin, Daniel Tome, Nicolas Darcel

Dynamics of Manganese Transport in the Rat Optic Nerve Evaluated Using Manganese-Enhanced MRI (MEMRI) ...... 1864 Øystein Olsen, Pål Erik Goa, Andres Kristoffersen, Axel Sandvig, Christian Brekken, Marte Thuen

Morphological Study of Mouse Brain Models with Down Syndrome Using MEMRI ...... 1865 Bich-Thuy Doan, Eva Toth, Ahmad Almhdie, Patricia Lopes-Pereira, Paulo Loureiro de Sousa, Sandra Meme, Frédéric Szeremeta, Caroline Colombier, Véronique Brault, Christophe Leger, Roger Ledee, Rachid Harba, Yann Herault, Jean-Claude Beloeil

Quantitative MEMRI Mapping of Ion Channel Regulation by Visual Cycle Activity in Rodent Photoreceptors In Vivo ...... 1866 Bruce Berkowitz, Robin Roberts, Dave Bissig

Evidence for Coupling Between Cerebellum and Basal-Ganglia Loops – an MEMRI Study...... 1867 Benjamin Matta, Gadi Goelman

Mapping Brain Activations Induced by Exposure to Enriched Environment with Manganese-Enhanced Magnetic Resonance Imaging...... 1868 Xuxia Wang, Fuchun Lin, Liqin Yang, Zhao Li, Hao Lei

Segmentation and Calculation of Stroke- And Manganese-Enhanced Volumes After Reconstruction of the Injured Hemisphere in the Hypoxic-Ischemic Neonatal Rat Brain ...... 1869 Øystein Olsen, Marius Widerøe, Pål Erik Goa, Jon Skranes, Ann-Mari Brubakk, Christian Brekken

Late Manganese-Enhanced MRI of Rat Cortical and Subcortical Structures...... 1870 Kevin C. Chan, Iris Y. Zhou, Ed X. Wu

Effect of Ethanol Treatment on Axonal Transport Rates in Hyper-Glutamatergic Transgenic Mice...... 1871 Jieun Kim, In-Young Choi, Elias K. Michaelis, Sang-Pil Lee

Manganese Enhanced MRI Tracing for Spinal Cord Injury ...... 1872 Nikolay L. Martirosyan, Kevin M. Bennett, Nicholas Theodore, Mark C. Preul

MEMRI and Single Pellet Reaching in Rats ...... 1873 Albert R. Cross, Mariam Alaverdashvili, Valerie Lapointe, Ian Q. Whishaw

Evaluation of Hippocampal Degeneration After Prenatal Radiation Exposure Using Manganese-Enhanced MRI (MEMRI)...... 1874 Shigeyoshi Saito, Xue-Zhi Sun, Kazuhiko Sawada, Tetsuya Suhara, Iwao Kanno, Ichio Aoki

In Vivo 1H-MR Spectroscopy of the Mouse Cervical Spinal Cord...... 1875 Virginie Callot, Yann Le Fur, Guillaume Duhamel, Patrick J. Cozzone, Frank Kober

Magnetic Resonance Microscopy of Mammalian Neurons...... 1876 Jeremy J. Flint, Choong-Heon Lee, Brian Hansen, Michael Fey, Daniel Schmidig, Jonathan D. Bui, Michael A. King, Peter Vestergaard-Poulsen, Stephen J. Blackband

Assessment of Pathologic Mouse Spinal Cord Recovery Using High-Resolution Diffusion and ASL-Based Perfusion Imaging ...... 1877 Guillaume Duhamel, Patrick Decherchi, Tanguy Marqueste, Patrick J. Cozzone, Virginie Callot

Tracking Iron Labeled Cells in Direct Transplant Models, Proceed with Caution...... 1878 Laura Elizabeth Gonzalez-Lara, Xiaoyun Xu, Klara Hofstetrova, Anna Pniak, Arthur Brown, Paula J. Foster

High Resolution 3D Myelin Water Imaging in Excised Rat Spinal Cord ...... 1879 Piotr Kozlowski, Andrew C. Yung

Visualization of Vascular Modifications Occuring During Spinal Cord Injury (SCI) Recovery Using High- Resolution Arterial Spin Labeling (ASL) ...... 1880 Guillaume Duhamel, Patrick Decherchi, Tanguy Marqueste, Patrick J. Cozzone, Virginie Callot

Preclinical Screening of a Potential Drug Treatment for Spinal Cord Injury Using Magnetic Resonance Imaging ...... 1881 Peter Cheng-te Chou, Mehmet Levend Gunsoy, Mohamed Mokhtar Desouki, Shunmugavel Anandakumar, Musfiquiddin Khan, Hanaa El Sayed, Shaun Nguyen, Inderjit Singh, Mehmet Bilgen

Multiexponential T2 Analysis of Rat Brain and Spinal Cord ...... 1882 Cheryl R. McCreary, Thorarin A. Bjarnason, J Ross Mitchell, Jeff F. Dunn

Respiration-Induced B0 Fluctuation of Spine...... 1883 Hahnsung Kim, Sang-Young Zho, Dong-Hyun Kim

Toward a Better Description of the Gray Matter Spinal Cord by Using Highly Resolved Diffusion-Weighted and Morphologic T2*-Weighted MRI ...... 1884 Virginie Callot, Guillaume Duhamel, Alexandre Vignaud, Patrick J. Cozzone

Assessment of CSF Flow and Spinal Cord Motion in Cervical Spondylosis Using Phase Contrast MRI...... 1885 Sandra Michelle Meyers, Erin L. MacMillan, Burkhard Mädler, Irene M. Vavasour, David K. Li, Marcel F. Dvorak, Armin Curt, Alex L. MacKay

Sensitivity of Myelin Water Imaging in Focal Spinal Cord Demyelination: A Combined Neurophysiological and Neuroimaging Study of Cervical Spondylotic Myelopathy...... 1886 Erin Leigh MacMillan, Alexander L. MacKay, Burkhard Mädler, David K. Li, Marcel F. Dvorak, Armin Curt

Myelin Water Imaging with MRI at 3.0T in the Healthy Human Spinal Cord: Reproducibility and Changes with Age...... 1887 Erin Leigh MacMillan, Armin Curt, Burkhard Mädler, David K. Li, Marcel F. Dvorak, Alexander L. MacKay

Multi-Exponential Analysis of T2 Relaxation in the Human Spinal Cord: Differences Between Grey and White Matter ...... 1888 Nicole Fichtner, Erin L. MacMillan, B Mädler, A Curt, D K. Li, M F. Dvorak, Alex L. MacKa

Point Spread Function Mapping for Distortion Correction of Spinal Cord Diffusion Weighted MRI...... 1889 Henrik Lundell, Julien Cohen-Adad,

BLADE in Sagittal T2-Weighted Imaging of the Cervical Spine: Reduction of Artifacts and Value for Clinical Application ...... 1890 Claudia Fellner, Cynthia Menzel, Franz A. Fellner, Christine Ginthör, Niels Zorger, Ernst M. Jung, Stefan Feuerbach, Thomas Finkenzeller

Diffusion Tensor Imaging of Subjects with Cervical Spondlytic Myelopathy: Use of the Eigenvalues as Indicators of Spinal Stenosis ...... 1891 Enedino Hernandez, Alex L. Mackay, Erin L. MacMillan, Burkard Mädler, David K. Li, M F. Dvorak, Teodoro Cordova, Alonso Ramirez-Manzanares, C Laule

Optimization of Flip Angles in SPGR Imaging for Quantitative T1 Mapping of the Cervical Spinal Cord at 3.0 T...... 1892 Iordanis E. Evangelou, Vasiliki N. Ikonomidou, Marcela Montequin, Nancy D. Richert, Henry F. McFarland, Steve Jacobson

Evaluation of CSF Flow Alteration in Patients with Idiopathic Spinal Cord Using SPAMM Technique ...... 1893 Woo-Suk Chung, Tae-Sub Chung, Sang Hyun Suh, Chul Hwan Park

Diagnosis of Lumbar Spondylolysis in Children and Adolescents on MR Imaging: Comparison with CT ...... 1894 Motoyuki Katayama, Takayuki Masui, Kimihiko Sato, Hiroki Ikuma, Hidekazu Seo, Akihiko Kutsuna

Implementation of Axial Diffusion Tensor Imaging in the Lumbar Spinal Cord at 3T...... 1895 Tobias Maximilian Lindig, Sarah C. Mang, Sibylle E. Heide, Vinod Kumar, Thomas Nägele, Wolfgang Grodd, Ludger Schöls, Uwe Klose

Spinal Cord and Brainstem Activation in Carpal Tunnel Syndrome Patients in Response to Noxious Stimuli: A Spinal fMRI Study...... 1896 Jordan K. Leitch, Cathy M. Cahill, Niousha Foad Ghazni, Chase R. Figley, Patrick W. Stroman

Diffusion Tensor Imaging of Human Cervical Spinal Cords in Cervical Myelopathy...... 1897 T. H. Kim, S. E. Kim, Alpesh A. Patel, Lauren Zollinger, John Rose, E. K. Jeong

Diffusion-Weighted Magnetic Resonance Imaging of Nasopharngeal Carcinoma...... 1898 Devin Kwan Ying Fong, Ann Dorothy King, Francis KH Lee, Queenie Chan, David Ka Wai Yeung

Parallel Imaging of the Upper Airway with a Novel 16-Channel Tongue Coil ...... 1899 Yoon-Chul Kim, Cecil E. Hayes, Shrikanth S. Narayanan, Krishna S. Nayak

High-Resolution Larynx Imaging...... 1900 Joelle Karine Barral, Holden H. Wu, Edward J. Damrose, Nancy J. Fischbein, Dwight George Nishimura

Non-Gaussian Analysis of Diffusion Weighted MRI in Head and Neck Cancer: A Feasibility Study ...... 1901 Jacobus F.A. Jansen, Hilda E. Stambuk, Jason A. Koutcher, Amita Shukla-Dave

Carotids Imaging at 7 Tesla Using Traveling Wave Excitation and Local Receiver Coils ...... 1902 Hugo Kroeze, Bart L. van de Bank, Fredy Visser, Jan J.W. Lagendijk, Peter Luijten, Dennis W.J. Klomp, Cornelis A.T. van den Berg

1H-MRS and 18FDG PET: Metabolism in Head and Neck Cancers ...... 1903 Jacobus F.A. Jansen, Heiko Schoder, Nancy Lee, Hilda E. Stambuk, David G. Pfister, Jatin P. Shah, Jason A. Koutcher, Amita Shukla-Dave

Assessment of Tumor Microenvironment Using DCE MRI and 18Fluoromisonidazole PET Imaging in Neck Nodal Metastases...... 1904 Jacobus F.A. Jansen, Heiko Schoder, Nancy Lee, Ya Wang, David G. Pfister, Matthew G. Fury, Hilda E. Stambuk, Jason A. Koutcher, Amita Shukla-Dave

Evaluation of the Vocal Tract with Real Time MRI and MRI Volumetry in Professional Tenors ...... 1905 Matthias Echternach, Tobias Baumann, Johan Sundberg, Bernhard Richter, Michael Markl

Optimizing Flip Angle and Injection Rate for Combined First Pass and Steady State Imaging of the Supraaortic Vasculature Using Gadofosveset Trisodium at 1.5 T MRI – a Volunteer Study...... 1906 Frederik L. Giesel, Michael Bock, Lars Gerigk, Nadja Komm, Karsten Bergmann, Amit Mehndiratta, Marco Essig

High Resolution Imaging of the Membranous Labyrinth: A Comparison of 3D CISS and 3D SPACE at 1.5T...... 1907 Bradley D. Bolster Jr. , John I. Lane, Kevin J. Johnson, Sarah D. Inglett, Matthew A. Bernstein, Jonathan M. Morris, Robert J. Witte

High Resolution Cochlear Imaging with Dual Gradients ...... 1908 Amy de la Garza, K Craig Goodrich, Seong-Eun Kim, Sung Man Moon, Dennis L. Parker

BLADE for T1-Weighted Contrast with Spectral Fat Suppression: Two Different Approaches for Head and Neck Imaging ...... 1909 Claudia Fellner, Niels Zorger, Ernst M. Jung, Stefan Feuerbach, Thomas Finkenzeller

Consistent Automated Planning of Irregular ROI’s for Intracranial MRA MIP’s...... 1910 Chiel J. den Harder, Elizabeth A. Moore, Arianne M. van Muiswinkel

Studying the Hemodynamics in Cerebral Arteries Using Image-Based Computational Fluid Dynamics and 4D Phase-Contrast Magnetic Resonance ...... 1911 Juan R. Cebral, Christopher M. Putman, Marcus Alley, Roland Bammer, Fernando Calamante

A New Method for Selective Dynamic MRI Angiography Using Arterial Spin Labeling...... 1912 Tom Okell, Matthias Guenther, David A. Feinberg, Peter Jezzard

MRI Assessment of Blood Flow Artifacts in a Transgenic Mouse Model of Alzheimer’s Disease...... 1913 Firat Kara, Janneke Ravensbergen, Niels Braakman, Mark A. van Buchem, Reinhard Schliebs, Huub J. M. de Groot, A Alia

In Vivo Visualization of Brain Tumour Angiogenesis Using 3D ΔR2-Based Microscopic MR Angiography (3DΔR2- mMRA) ...... 1914 Chien-Yuan Lin, Ming-Huang Lin, Sui-Shan Lin, Yu-Ying Tung, Jyh-Horng Chen, Chen Chang

Comparison of Hypercapnia- And Hyperoxia-Induced Blood Flow Changes in the Retina Detected by MRI and Laser Speckle Imaging...... 1915 Haiying Cheng, Yumei Yan, Yingxia Li, Timothy Q. Duong

4D Velocity Measurements in an Intracranial Aneurysm Using 3T Phase Contrast Angiography...... 1916 Pim van Ooij, Joppe J. Schneiders, Marieke E.S. Sprengers, Ed van Bavel, Aart J. Nederveen, Charles B.L.M. Majoie

Assessment of the Neovascularisation of Carotid Atherosclerotic Plaque in Symptomatic Patients at 3T by DCE- MRI: Feasibility Study...... 1917 N. Jane Taylor, Vicky J. Goh, J James Stirling, Ian Simcock, Matthew Orton, David J. Collins, Ralph Strecker, Leon Menezes, Justin Cross, Carl W. Kotze, Syed W. Yusuf, Ashley M. Groves

The Role of 4D MRA with Keyhole and View-Sharing at 3.0T in the Diagnostic Work-Up of Cerebral Arteriovenous Malformations: A Prospective Intra-Individual Study ...... 1918 Dariusch Reza Hadizadeh, Guido M. Kukuk, Jürgen Gieseke, Gabriele Beck, Liesbeth Geerts, Julia Bergener, Azize Boström, Johannes Schramm, Horst Urbach, Hans Heinz Schild, Winfried Albert Willinek

Quantitative MR Perfusion in Patients with Intracranial Arteriovenous Malformations: Utilizing Spin-Echo Sequences to Characterize Vascular Steal...... 1919 Christopher Sean Eddleman, Jessy J. Mouannes, Anindya Sen, Guilherme Dabus, Christopher C. Getch, Bernard R. Bendok, Hunt H. Batjer, Timothy J. Carroll

Evaluation of Blood Flow from STA-MCA Bypass by MRA with Off-Sagittal Saturation Pulse ...... 1920 Toshiaki Akashi, Toshiaki Taoka, Hiroyuki Nakagawa, Toshiteru Miyasaka, Masahiko Sakamoto, Satoru Kitano, Satoru Iwasaki, Kimihiko Kichikawa

Evaluation of Perforating Arteries Originating from the Posterior Communicating Artery at 7 Tesla MRI...... 1921 Mandy M. Conijn, Jeroen Hendrikse, Jaco J. Zwanenburg, Taro Takahara, Mirjam I. Geerlings, Willem P. Mali, Peter R. Luijten

Assessing Cerebrospinal Fluid Flow in the Brain Using 3D Phase Contrast Velocity Encoded MRI ...... 1922 Henrik Odéen, Michael Markl, Bruce S. Spottiswoode

Is Flow Rate or Stroke Volume Better for the Assessment of CSF Flow in NPH? ...... 1923 Mario Forjaz Secca

MR Arterial Spin Labeling and Spectroscopy in Patients with Symptomatic Internal Carotid Artery Occlusion ...... 1924 Jie Lu, Kuncheng Li, Miao Zhang

Feasibility of Imaging Mesenchymal Stem Cells in Vitro Using Standard MRI Sequences...... 1925 Emidio Tarulli, Voytek Gretka, Amy Hoyles, Cindi Morshead, Greg J. Stanisz

Limitations of Iron-Based Stem Cell Tracking in MRI-Monitoring of Stem Cell Therapies in Vivo ...... 1926 Emidio Tarulli, Voytek Gretka, Amy Hoyles, Cindi Morshead, Greg J. Stanisz

Novel Combination Therapy of Recombinant Annexin 2 and Low Dose Recombinant Tissue Plasminogen Activator in Embolic Rat Stroke Model: A Magnetic Resonance Imaging Study ...... 1927 Yoji Tanaka, Tsukasa Nagaoka, Govind Nair, Qiang Shen, Xiaodong Zhang, Timothy Q. Duong

Effect of NBO Treatment on Lesion Volume at Early and Late Reperfusion Time Points After Transient Focal Cerebral Ischemia ...... 1928 J Ramu, W Liu, KJ Liu, R Sood

Aging and Hypertension Increase the Susceptibility of Brain Tissue to Ischemic Injury: Animal Brain MR Imaging Study...... 1929 MeiYu Yeh, Tsong-Hai Lee, Ho-Ling Liu

Temporal MRI Profile of Hermorrhagic Transformation After Embolic Stroke in Spontaneously Hypertensive Rats...... 1930 Ivo Adriaan Carol Willem Tiebosch, Annette van der Toorn, René Zwartbol, Mark Jacobus Rosalie Joseph Bouts, Ona Wu, Rick Michiel Dijkhuizen

Multiparametric MRI Correlation with Tissue Outcome in Early Phase of Acute Ischemic Stroke in Rats...... 1931 Kimmo Jokivarsi, Yrjö Hiltunen, Risto Kauppinen, Olli Gröhn

Late Stimulation of the Sphenopalatine Ganglion in Ischemic Rats Improves NAA Levels and DWI Characteristics...... 1932 Amnon Bar-Shir, Noam Shemesh, Revital Nossin-Manor, Yoram Cohen

Localized 1H MRS of Mouse Brain in Vivo Reveals Metabolic Markers Predicting the Development of Ischemic Damage ...... 1933 Hongxia Lei, Carole Berthet, Lorenz Hirt, Rolf Gruette

Molecular MRI of Thrombus in a Rat Ischemic Stroke Model ...... 1934 Ritika Uppal, Ilknur Ay, Guangping Dai, Young Ro Kim, Gregory Sorensen, Peter Caravan

Application of a Modified Quantitative BOLD Approach to Monitor Local Blood Oxygen Saturation in Two Glioma Models and a Stroke Model in Rat ...... 1935 Thomas Christen, Benjamin Lemasson, Nicolas Pannetier, Olivier Detante, Régine Farion, Emmanuelle Grillon, Christoph Segebarth, Chantal Rémy, Emmanuel L. Barbier

Combined in Vivo MR and Optical Imaging of Stroke Induced Neurogenesis in the Mouse Brain...... 1936 Tracy Deanne Farr, Dirk Wiedermann, Sébastien Couillard-Després, Luwig Aigner, Mathias Hoehn

High Resolution Diffusion Tensor Imaging of Post-Stroke White Matter Integrity in Ex Vivo Rat Brain ...... 1937 Maurits P.A. van Meer, Willem M. Otte, Kajo van der Marel, Annette van der Toorn, J. W. Berkelbach van der Sprenkel, Rick M. Dijkhuizen

The Diffusion Tensor Reveals Gray Matter Architecture ...... 1938 Sune Norhoj Jespersen, Lindsey A. Leigland, Anda Cornea, Christopher David Kroenke

The Effect of Axonal “Beading” on Water Diffusion Properties: a Monte Carlo Simulation of Axonal Degeneration and Its Effects on DTI Contrasts ...... 1939 Jonathan A.D. Farrell, Bennett A. Landman, Jiangyang Zhang, Seth Smith, Daniel S. Reich, Peter A. Calabresi, Peter C. van Zijl

Understanding the Recuded ADC in Stroke Lesions Using Repeated Measurements with Different Diffusion Times ...... 1940 Markus Nilsson, Jimmy Lätt, Danielle van Westen, Stig Holtås, Ronnie Wirestam, Freddy Ståhlberg, Sara Brockstedt

Evaluation of the Effect of Exchange on the Diffusion Weighted MR-Signal in Brain White Matter ...... 1941 Els Fieremans, Yves De Deene, Jens H. Jensen, Joseph A. Helpern

Renormalization Group Method: Enhancement of Basser-Sen Model of the Brain White Matter...... 1942 Oleg P. Posnansky, N. Jon Shah

A Study on the Validity of the Tortuosity Approximation for Extracellular Diffusion Using Monte Carlo Simulations...... 1943 Hubert Martinus Fonteijn, Matt G. Hall, Daniel C. Alexander

Trace Weighting in Double Wave Vector Diffusion Experiments in Vivo...... 1944 Martin A. Koch, Jürgen Finsterbusch

Assessment of Tissue Properties and T2 Relaxation on ADC Measurements by Numerical Simulation of Water Diffusion ...... 1945 Kevin D. Harkins, Jean-Phillipe Galons, Timothy W. Secomb, Theodore P. Trouard

Validation of Models for the Diffusion Weighted MR Signal in Brain White Matter...... 1946 Els Fieremans, Yves De Deene, Jens H. Jensen, Joseph A. Helpern

Evidence for a Vascular Contribution to the Biexponential Signal Decay as a Function of the b-Value in DWI: A Verification of the IVIM-Model...... 1947 Andreas Lemke, Lothar Rudi Schad, Bram Stieltjes, Frederik Laun q-space MR Propagator in Partially-Restricted, Axially-Symmetric and Isotropic Environments ...... 1948 Evren Ozarslan, Cheng Guan Koay, Peter J. Basser

Analysis of Water Diffusion in White Matter Using a Hydration Layer Model ...... 1949 Elena Olariu, Ian Cameron

Treatment Response of Non-Monoexponential Diffusion in a Glioma Rodent Model ...... 1950 Benjamin Hoff, Denis Le Bihan, Alnawaz Rehemtulla, Thomas Chenevert, Brian Ross, Craig Galbán

Dependence of Fractional Order Diffusion Model Parameters on Diffusion Time ...... 1951 Xiaohong Joe Zhou, Qing Gao, Girish Srinivasan, Richard L. Magin

Diffusion Diffraction Patterns in Different Cells ...... 1952 Davide Imperati, M. Cross, Klaus Kruttwig, P. Galvosas, Konstantin Ulrich, Andrè Pampel, Jörg Kärger, Mathias Hoehn, Harald E. Möller, Marc Tittgemeyer

Preliminary Experiences with Implementing High Resolution CSF-Suppressed Optic Nerve DTI at 3.0T with and Without Parallel Imaging ...... 1953 Rebecca Sara Samson, Mark R. Symms, David L. Thomas, Madhan Kolappan, David H. Miller, Claudia A M Wheeler-Kingshott

Improvement of DTI Measurement Using the Composite Gradient Systems on a Clinical 3T MRI System: DTI Study of Ex Vivo Dog's Heart ...... 1954 Seong-Eun Kim, K Craig Goodrich, Sung M. Moon, J. Rock Hadley, Dennis L. Parker

Accelerating Diffusion Tensor Imaging Using Multi-Reference Image Constrained Reconstruction...... 1955 Lindsey Jean Healy, Osama Abdullah, Edward W. Hsu

High b-value Acquisition Using CURVE-Ball DTI...... 1956 Sharon Peled, Stephen Whalen, Alexandra Golby

Apparent Diffusion Coefficient Measurement of in Vivo Atherosclerotic Plaque Obtained from Six Human Subjects Using 2D ss IMIV DWEPI Technique on 3T System...... 1957 Seong-Eun Kim, Eun-Kee Jeong, J. Rock Hadley, John A. Roberts, Gernald A. Trieman, Laura C. Bell, Dennis L. Parker

Parallel Line Scan Diffusion Imaging with 2D Acceleration ...... 1958 Renxin Chu, Bruno Madore, Lawrence P. Panych, Mohammed H. Aljallad, Stephan E. Maier

Measuring and Correcting Errors That Occur in Diffusion Weighted Images Due to Non-Ideal Gradient Linearity...... 1959 Zoltan Nagy, Daniel C. Alexander, Nikolaus Weiskopf

Feasibility of In-Vivo Diffusion Tensor Echo Planar Imaging and Fiber Tracking at 14.1T...... 1960 Nicolas Kunz, Yohan van de Looij, Petra S. Hüppi, Stéphane V. Sizonenko, Rolf Gruetter

Comparison of Reduced-FOV Single-Shot EPI Methods for DWI: ZOOM-EPI vs. 2D Echo-Planar RF Excitation...... 1961 Emine Ulku Saritas, Ken-Pin Hwang, Eric T. Han, Jin Hyung Lee, Dwight George Nishimura, Ajit Shankaranarayanan

Double-Spin-Echo Diffusion Weighting with a Modified Eddy-Current Adjustment ...... 1962 Jürgen Finsterbusch

K-Space and Image Space Combination for Motion-Induced Phase Error Correction in 3D Diffusion-Weighted Imaging ...... 1963 Anh Tu Van, Dimitrios C. Karampinos, Bradley P. Sutton

Hadamard Slice Encoding for Reduced-FOV Single-Shot Diffusion-Weighted EPI...... 1964 Emine Ulku Saritas, Ajit Shankaranarayanan, Dwight George Nishimura

Pearson Set of Distributions as Improved Signal Model for Diffusion Kurtosis Imaging ...... 1965 Dirk H. J. Poot, Arjan J. den Dekker, Jan Sijbers

Importance of Multiscale Analysis in HARDI Studies...... 1966 Irina Kezele, Cyril Poupon, Maxime Descoteaux, Fabrice Poupon, Jean-François Mangin

Groupwise Non-Rigid Registration of 4th-Order Diffusion Tensor Fields and Atlas Construction...... 1967 Angelos Barmpoutis, Baba C. Vemuri, Dena Howland, John R. Forder

A Comparison of Two Models of Anomalous DWI Based on a Known Distribution of Water Diffusion Rates...... 1968 Chu-Yu Lee, Kevin M. Bennett, Lina J. Karam, Joseph P. Debbins

Non-Rigid Registration of Diffusion Weighted Images Using Fibre Orientation Distributions...... 1969 David Raffelt, J-Donald Tournier, Jurgen Fripp, Natasha Lepore, Stuart Crozier, Alan Connelly, Olivier Salvado

Spatial Transformations of Fiber Orientation Fields...... 1970 Rafael Alonso Clarke, Giovanna Rizzo, Daniela Perani, Giuseppe Scotti, Ferruccio Fazio, Paola Scifo

A Polynomial Based Approach to Extract Fiber Directions from the ODF and Its Experimental Validation ...... 1971 Aurobrata Ghosh, Elias Tsigaridas, Maxime Descoteaux, Rachid Deriche

Estimation of Cell Size Using the Composite Hindered and Restricted Model of Diffusion...... 1972 Yaniv Sagi, Peter J. Basser, Yaniv Assaf

Diffusion Propagator Imaging (DPI): An Alternative to Diffusion Spectrum Imaging (DSI)...... 1973 Maxime Descoteaux, Kuan-Hung Cho, Yi-Ping Chao, Chun-Hung Yeh, Jean-François Mangin, Ching-Po Lin, Cyril Poupon

Using Spatial Priors for Better Reconstruction of Fiber Orientation Function in Diffusion MRI ...... 1974 Ashish Raj, Christopher Hess, Pratik Mukherjee

Computed Tomographic (CT) Reconstruction of the Average Propagator from Diffusion Weighted MR Data ...... 1975 Wolfram R. Jarisch, Evren Özarslan, Peter J. Basser

Optimizing the Diffusion Weighting Gradients for Diffusion-Kurtosis Imaging...... 1976 Dirk H. J. Poot, Arjan J. den Dekker, Marleen Verhoye, Ines Blockx, Johan Van Audekerke, Annemie Van Der Linden, Jan Sijbers

Regularized Q-Ball Reconstruction: Robust Estimation, Model Selection, and Spatial Denoising ...... 1977 Jaime E. Cisternas, Pedro Daza, Takeshi Asahi, Tim B. Dyrby, Klaus Fritzsche

Simple Harmonic Oscillator Based Reconstruction and Estimation for Three-Dimensional Q-Space MRI...... 1978 Evren Ozarslan, Cheng Guan Koay, Timothy M. Shepherd, Stephen J. Blackband, Peter J. Basser

Axon Radius Estimation Using Optimised Stejskal–Tanner and Dual Spin-Echo Sequences at Modest SNR...... 1979 Jonathan D. Clayden, Zoltan Nagy, Daniel C. Alexander, Chris A. Clark

NEX or No NEX? a High Angular Resolution Diffusion Imaging Study...... 1980 Maxime Descoteaux, Nicolas Wiest-Daesslé, Sylvain Prima, Christian Barillot, Rachid Deriche, Cyril Poupon

An Open Source Monte Carlo Framework for Simulating Diffusion in Biologically Relevant Geometries Including Broken, Crimped and Bulging Axons ...... 1981 Bennett Allan Landman, Jonathan A. Farrell, Peter C. van Zijl

Millimeter Analytical Q-Ball Fiber Density Function for a Better Separation of Fiber Populations at 7T...... 1982 Cyril Poupon, Christopher J. Wiggins, Maxime Descoteaux, Thorsten Feiweier, Jean-François Mangin, Denis Le Bihan

Using a Mixture of Watson Distributions to Estimate Intrinsic Fiber Diffusion Properties ...... 1983 Ha-Kyu Jeong, John C. Gore, Adam W. Anderson

Fanning and Bending Sub-Voxel Structures in Diffusion MRI ...... 1984 Shahrum Nedjati-Gilani, Daniel C. Alexander

Rapid Data Acquisition and Post-Processing for Diffusional Kurtosis Imaging...... 1985 Jens Hesselberg Jensen, Caixia Hu, Joseph A. Helpern

Outlier Detection for Diffusion Tensor Imaging by Testing for ADC Consistency ...... 1986 Hangyi Jiang, Min-chung Chou, Peter C.M. van Zijl, Susumu Mori

Estimation of the Eddy-Current Induced Magnetic Field from Affine-Transformation Parameters and Its Relevance for the Comparability of DTI Data ...... 1987 Siawoosh Mohammadi, Harld Möller, Harald Kugel, Dirk Müller, Michael Deppe

Comparison of SNR and Diffusion Parameters on 1.5, 3.0 and 7.0 Tesla...... 1988 Daniel Polders, Hans Hoogduin, Manus Joseph Donahue, Jeroen Hendrikse, Peter Luijten

Less Severe Spinal Cord Injury in Dysmyelinated Mice Evaluated Using DTI and Locomotion...... 1989 Tsang-Wei Tu, Joong Hee Kim, Sheng-Kwei Song

Fitting to Magnitude Diffusion MRI Data Using a Least Squares Algorithm Gives Biased ADC Values and Is Less Able to Characterise Necrosis ...... 1990 Simon Walker-Samuel, Matthew Orton, Lesley D. McPhail, Simon P. Robinson

On the Battle Between Rician Noise and Phase-Interferences in DWI ...... 1991 Stefan Skare, Samantha Holdsworth, Rexford D. Newbould, Roland Bammer

Automated Image Quality Assessment for Diffusion Tensor Data...... 1992 James Meakin, Serena Counsell, Emer Hughes, Jo V. Hajnal, David J. Larkman

Exploring the White Matter Microstructure Underpinning Electrophysiological Dynamics: A Combined DT-MRI and MEG Study ...... 1993 Derek K . Jones, Alex Leemans, Christopher John Evans, Krish D. Singh, Suresh D. Muthukumaraswamy

Quantitative Mapping of Diffusion Characteristics Under the Cortical Surface...... 1994 Bang-Bon Koo, Vibhu Sachdev, Jong Min Lee, Dae-Shik Kim

Simulated DTI Data Sets for the Evaluation of Voxel Based Analysis Methods...... 1995 Wim Van Hecke, Alexander Leemans, Steve De Backer, Paul M. Parizel, Jan Sijbers

Polyvinylpyrrolidone (PVP) Water Solutions as Isotropic Phantoms for Diffusion MRI Studies...... 1996 Carlo Pierpaoli, Joelle Sarlls, Uri Nevo, Peter J. Basser, Ferenc Horkay

Effects of Preprocessing on Goodness of Fit Measures in Premature Neonatal DTI ...... 1997 Drew Morris, Revital Nossin-Manor, Margot J. Taylor, John G. Sled

Longitudinal Changes in Diffusivity After Long-Term Storage of Postmortem Tissue...... 1998 Tim B. Dyrby, William FC. Baaré, Daniel C. Alexander, Jacob Jelsing, Ellen Garde, Lise V. Søgaard

DTI Smoothing by Hierarchical, Adaptive and Robust Strategy ...... 1999 Songyuan Tang, Yong Fan, Hongtu Zhu, Wei Gao, Weili Lin, Dinggang Shen

Analysis of High B-Value Diffusion Images Using a Fractional Order Diffusion Model with Denoising Image Reconstruction ...... 2000 Qing Gao, Justin P. Haldar, Novena Rangwala, Richard L. Magin, Zhi-Pei Liang, Xiaohong Joe Zhou

Exploring Analytic Models of the Diffusion MR Signal in Fixed Rat Brain Tissue ...... 2001 Eleftheria Panagiotaki, Hubert M. J. Fonteijn, Shahrum Nedjati-Gilani, Matt G. Hall, Daniel C. Alexander

Diffusion Weighted Imaging of the Human Brain in P. falciparum Malaria...... 2002 Christina Louise Tosti, Jordan Muraskin, Xavier Golay, Jiraporn Laothamatas, Marc Van Cauteren, Melvyn B. Ooi, Varinee Lekprasert, Noppadon Tangpukdee, Srivicha Krudsood, Wattana Leowattana, Sornchai Looareesuwan, Polrat Wilairatana, Robert L. DeLaPaz, Gary M. Brittenham, Adam M. Brickman, Truman R. Brown

Quantitative Measures of Glioma Edge Characteristics on Diffusion Weighted Images – Interobserver Agreement...... 2003 John Robert Cain, Gerard Thompson, Samantha Jane Mills, Alan Jackson

Use of Fractional Anisotropy for Determination of the Cut-Off Value in 11C-Methionine Positron Emission Tomography for Glioma ...... 2004 Manabu Kinoshita, Naoya Hashimoto, Tetsu Goto, Takufumi Yanagisawa, Naoki Kagawa

Patching Cardiac and Head Motion Artefacts in Diffusion Imaging ...... 2005 Marcel Peter Zwiers

3 Measurement of Apparent Long-Range Diffusion of He Using Pulsed Gradient Spin Echo T2 in the Rat Lung at Low Magnetic Field Strength...... 2006 Giles Santyr, Ryan Kraayvanger, Xiaojun Xu, William Dominguez-Viqueira

Intravoxal V1-IP: An Improved White Matter Index Compared to Diffusion Anisotropy...... 2007 Shu-Wei Sun

Hierarchical Diffusion Tensor Image Registration Based on Tensor Regional Distributions...... 2008 Pew Thian Yap, Hongtu Zhu, Weili Lin, Dinggang Shen

Estimating White Matter Tract Volume in Partial Volume Voxels with Diffusion MRI...... 2009 Jakub P. Piatkowski, Amos J. Storkey, Mark E. Bastin

Between-Scanner Variation in Normal White Matter ADC in the Setting of a Multi-Center Clinical Trial ...... 2010 Jing Huo, Matthew S. Brown, Jeffry R. Alger, Hyun J. Kim, Whitney B. Pope, Jonathan G. Goldin

Multiple Fiber Diffusion Anisotropy Analysis in Autistic Children ...... 2011 Zhenyu Zhou, Weihong Guo, Tianyu Tang, Wei Liu, Bradley S. Peterson, Yijun Liu, Dongrong Xu

Phenotyping Aging of the Spontaneously Hypertensive Rat Brain Using 3D Diffusion Tensor Imaging at 9.4T: A Preliminary Study ...... 2012 Ping Wang, Suzanne Wehrli, Elizabeth Stambrook, Christos Davatzikos, Ragini Verma, Thomas Floyd

Improving Diffusion Tensor Imaging Segmentation Through an Adaptive Distance Learning Scheme...... 2013 Paulo Reis Rodrigues, Anna Vilanova, Thorsten Twellmann, Bart M. ter Haar Romeny

Diffusion Tensor Shape and Tertiary Eigenvector Encoded Colormaps Reveal Features in Human Brain Tumor...... 2014 L-H. Dennis Cheong, C-C. Tchoyoson Lim

Evolution of Diffusion Tensor Parameters After Permanent Experimental Stroke in Rats...... 2015 Miia Pitkonen, Usama Abo-Ramadan, Eric Pedrono, Ivan Marinkovic, Daniel Strbian, Aysan Durukan, Turgut Tatlisumak,

Diffusion Anisotropy Measure Based on the Basis of Tesseral Harmonics ...... 2016 Yuliya Kupriyanova, Oleg Posnansky, N. Jon Shah

Effect of b-Value and TE on the Estimation of Intramyocellular Diffusion Properties in the Presence of Edema ...... 2017 Bruce M. Damon

Stochastic Fibre Tracking: An Average Curves Approach...... 2018 Nagulan Ratnarajah, Andy Simmons, Ali Hojjat

Diffusion Simulation Tractography for High Angular Resolution Diffusion Imaging...... 2019 Ning Kang, Gregory T. Balls, Lawrence R. Frank

Probabilistic Fiber Tracking Using the Residual Bootstrap with Constrained Spherical Deconvolution MRI ...... 2020 Ben Jeurissen, Alexander Leemans, Jacques-Donald Tournier, Jan Sijbers

Free-Spin Tracking: A Novel Global Tractography Algorithm...... 2021 Pierre Fillard, Cyril Poupon, Jean-François Mangin

Model-Based Streamline Rejection for Probabilistic Tractography ...... 2022 Jonathan D. Clayden, Chris A. Clark

Preliminary Results on the Use of STAPLE for Evaluating DT-MRI Tractography in the Absence of Ground Truth ...... 2023 Sonia Pujol, Carl-Fredrik Westin, Ross Whitaker, Guido Gerig, Tom Fletcher, Vincent Magnotta, Sylvain Bouix, Ron Kikinis, William M. Wells III, Randy Gollub

Whole-Brain Track-Density Mapping as a Tool for Fiber Tractography ...... 2024 Fernando Calamante, Jacques-Donald Tournier, Heath Pardoe, Alan Connelly

A Global Approach to Diffusion Tensor Neighborhood Tractography ...... 2025 Paul A. Armitage, Susana Munoz Maniega, Mark E. Bastin

Spatial Random Effects Modelling of Crossing Fibre Voxels in Diffusion MRI...... 2026 Martin David King, Chris Alan Clark, David Gadian

HYFF-HYbrid Tractography with Fiber Assignment by Continuous Tracking and Fast Marching ...... 2027 Hao Huang, Xin Fan

Measuring Error of Diffusion MRI-Based Brain Connectivity Matrices with Residual Bootstrap ...... 2028 Christopher T. Nguyen, Roland G. Henry, SungWon Chung

Improved Probabilistic Tractography Using Atlas-Based Fiber Tracking ...... 2029 Qing Xu, Adam W. Anderson, John C. Gore, Zhaohua Ding

Automated Registration, Segmentation and Labeling of White Matter Fiber Tracts...... 2030 Qing Xu, Adam W. Anderson, John C. Gore, Zhaohua Ding

Gender Differences in White Matter Microstructure in the Adult Brain Revealed by Tract Based Spatial Statistics ...... 2031 Emer Judith Hughes, David J. Sharp, Derek L.G Hill, Alle Meije Wink, Joseph V. Hajnal, Serena J. Counsell

Separate Assessment of Diffusion Properties of NAA and NAAG at 7T ...... 2032 Hermien E. Kan, Matthias J. P. van Osch, Maarten J. Versluis, Aranee Techawiboonwong, Mark A. van Buchem, Andrew J. Webb, Itamar Ronen

Separation of Fiber Tracts Within the Human Cingulum Bundle Using Single-Shot STEAM DTI with Partial Fourier Encoding and Parallel Imaging ...... 2033 Alexander Karaus, Sabine Hofer, Jens Frahm

How to Smooth Diffusion Tensor Images in a Voxel Based Analysis? ...... 2034 Wim Van Hecke, Alexander Leemans, Steve De Backer, Paul M. Parizel, Jan Sijbers

Diffusion Tensor Invariants and Principal Eigenvector Coherence Changes with Field Strength at Various b-Value Ranges...... 2035 Ai Wern Chung, Martin D. King, David L. Thomas, Roger J. Ordidge, Chris A. Clark

Segmentation and Characterisation of White Matter Tracts in Late Childhood and Adolescence...... 2036 Jonathan D. Clayden, Catherine J. Riney, Janine Cooper, Monica Muñoz, Chris A. Clark

Micro-Architectural Features of the in Vivo Human Optic Chiasm...... 2037 Joelle E. Sarlls, Carlo Pierpaoli

Stability of Diffusion Direction Based Thalamus Segmentation ...... 2038 Sarah C. Mang, Uwe Klose, Susanne Reiterer, Wolfgang Grodd

Detection of Motor Thalamus by Probabilistic Diffusion Density : Verification by Motor BOLD-Based fMRI...... 2039 Tzu-chen Yeh, Zong-Kai Hsu, Sue-Jin Lin, Chou-Ming Cheng, Jen-Chuen Hsieh, Low-Tone Ho

Mapping the Human Connectome at Multiple Scales with Diffusion Spectrum MRI ...... 2040 Leila Cammoun, Xavier Gigandet, Olaf Sporns, Jean-Philippe Thiran, Kim Q. Do, Philippe Maeder, Reto Meuli, Patric Hagmann,

Cingulum Bundle Asymmetry Predicts Trait Neuroticism: A DTI Study...... 2041 Kathrine Skak Madsen, Terry L. Jernigan, Arnold Skimminge, Erik Lykke Mortensen, Gitte M. Knudsen, William F.C. Baaré,

High Resolution Diffusion-Weighted Imaging Showing Radial Anisotropy in the Human Cortex in Vivo ...... 2042 Robin Martin Heidemann, Alfred Anwander, Thomas R. Knösche, Thorsten Feiweier, Fabrizio Fasano, Josef Pfeuffer, Robert Turner

Gender Differences in Correlations of Regional White Matter Integrity with Intelligence Factor Scores...... 2043 Johnny Ng, CheukYing Tang, Emily Eaves, Isabella Kanellopoulou, Xinsu Mai, David Carpenter, David Schroeder, Roberto Colom, Richard J. Haire,

Diffusion Tensor Imaging at 7T: Expectations Vs. Reality Check ...... 2044 Oliver Speck, Kai Zhong

Defining Arterial Input Function (AIF) in DSC-MRI: From Global to Local ...... 2045 Qing Ji, John O. Glass, Wilburm E. Reddick

DSC-MR Perfusion: Leave Tracer Recirculation Alone...... 2046 Jayme Cameron Kosior, Richard Frayne

Improved Assessment of Regional Cerebral Blood Flow by Dynamic Susceptibility Contrast MRI Using a Kernel- Based Deconvolution Approach...... 2047 Denis Peruzzo, Gianluigi Pillonetto, Alessandra Bertoldo, Claudio Cobelli

Can a Human Operator Be Replaced by a Computer for Processing of Bolus-Tracking Perfusion Data?...... 2048 Matus Straka, Michael Mlynash, Greg Zaharchuk, Gregory W. Albers, Roland Bammer

Estimation of CBF Values Using Multi-Echo DSC-MRI: a Comparison with a Xenon CT...... 2049 Matus Straka, Greg Zaharchuk, Rexford David Newbould, Gregory W. Albers, Michael E. Moseley, Roland Bammer

Limitations of a Multiplicative Correction of Partial Volume Effects on the Arterial Input Function in Bolus- Tracking Perfusion...... 2050 Adam Espe Hansen, Henrik Pedersen, Egill Rostrup, Henrik BW Larsson

Dynamic Susceptibility MRI with a Pre-Bolus Administration Design for Improved Absolute Quantification of Perfusion...... 2051 Linda Knutsson, Anna Rydhög, Danielle van Westen, Stig Holtås, Freddy Ståhlberg, Ronnie Wirestam

Estimation of Perfusion and Other Vascular Parameters from First Part of Bolus Passage ...... 2052 Lars G. Hanson, Henrik Lund, Irene K. Mikkelsen

Dose Optimization for Combined Perfusion Weighed Imaging and Contrast Enhanced MRA Using Gadofosveset ...... 2053 Erik Søndergaard Poulsen, Aage Kristian Olsen, Dora Zeidler, Niels Hjort, Leif Østergaard

Quantification of Vessel Permeability by Modeling Contrast Agent Extravasation in Dynamic Susceptibility Contrast MRI of Brain Tumors...... 2054 Yi-Ying Wu, Wei-Shan Yang, Yuan-Yu Hsu, Ho-Ling Liu,

Quantitative OEF Determination in Tumor Patients Using Additional DSC Measurements...... 2055 Moritz Mie, Maja Sohlin, Johann Scharf, Lothar Rudi Schad

Normative Blood Flow Values in the Posterior Fossa Using Quantitative Spin-Echo DSC Perfusion MRI...... 2056 Jessy J. Mouannes, Anahita Aghaei-Lasboo, Amir H. Yassari, Anindya Sen, Aaron Skolnik, Shahram Rahimi, Timothy J. Carroll, Bernard R. Bendok, Matthew T. Walker, Sandra W. Horowitz, Ali Shaibani

Dynamic Contrast Enhanced Whole Brain Perfusion Using a Rapid 3D T1-Weighted Sequence at 7T...... 2057 Paul S. Morgan, Emma C. Tallantyre, Ali Al-Radaidah, Jennifer E. Dixon, Matthew J. Brookes, Nikos Evangelou, Peter G. Morris

Quantitative Cerebral Perfusion in Rodents Assisted by Susceptibility Weighted Imaging ...... 2058 Rui Liu, Renjie He, Kurt H. Bockhorst, Venkata K. Mogatadakala, Ponnada A. Narayana

Gas-Filled Microbubbles as Intravascular Susceptibility Contrast Agent for Brain MRI...... 2059 Jerry S. Cheung, April M. Chow, Ed X. Wu,

Detection of Pulmonary Embolism with Hyperpolarized 3He MRI: A Comparison of pO2-Based and Susceptibility-Based Techniques...... 2060 Michelle E. Law, Jiangsheng Yu, Stephen Kadlecek, Kiarash Emami, Masaru Ishii, John MacDuffie-Woodburn, Matthew Stetz, Rahim R. Rizi

An Automated Method for Determination of Arterial Input and Venous Output Function Using Perfusion Parametric Joint Histogram Analysis ...... 2061 Hiroyuki Kabasawa, Tetsuji Tsukamoto

Intravascular Water Molecule Lifetime in the Japanese Macaque Brain ...... 2062 Jeffrey Moses Njus, James R. Pollaro, Mathew T. Snodgrass, John Cunneen, Ethan Muldoon, Vincent B. Warren, Xin Li, Charles S. Springer, Steven G. Kohama, William D. Rooney

Simultaneous Imaging of Absolute CBF Change and BOLD with Saturation-Recovery-T1 MRI Approach Under Ischemia and Hypercapnia...... 2063 Xiao Wang, Xiao Hong Zhu, Yi Zhang, Wei Chen

Rapid and Direct Quantification of Longitudinal Relaxation Time (T1) in Look-Locker Sequences Using an Adaptive Neural Network...... 2064 Hassan Bagher-Ebadian, Ramesh Paudyal, Tom Mikkelsen, Quan Jiang, James Russel Ewing,

Accuracy of Cerebral Blood Flow Measurements in Accelerated Dynamic Contrast Enhanced MRI Using k-t SENSE...... 2065 Henrik Pedersen, Adam Espe Hansen, Henrik B.W. Larsson

Dynamic Contrast Enhanced (DCE) MRI Metrices as a Predictor of Response in Head and Neck Cancers ...... 2066 Sushma Agrawal, Rishi Awasthi, Anup Singh, Ram Kishore Singh Rathore, Rakesh Kumar Gupta

Concurrent Measurement of Brain Perfusion, Blood Volume and Blood Brain Barrier Permeability Using Dynamic Contrast Enhanced T1 -Weighted MRI ...... 2067 Henrik BW Larsson, Frederic Courivaud, Egill Rostrup, Adam Espe Hansen

Enhancement of Gas-Filled Microbubble Magnetic Susceptibility by Iron Oxide Nanoparticles ...... 2068 April M. Chow, Jerry S. Cheung, Ed X. Wu,

Single-Shot Look Locker T1 Mapping with Golden Angle Radial Sampling for Free-Breathing Liver DCE-MRI in Rats at 1.5 T ...... 2069 Andreas Steingoetter, Jonas Svensson, Rickmer Braren, Rene Botnar, Stefanie Remmele

Developmental Analysis of Placental Vascularization Using Dynamic Contrast-Enhanced MRI...... 2070 Stav Sapoznik, Vicki Plaks, Elina Berkovitz, Rebecca Haffner-Krausz, Michal Neeman

Factor Analysis in Segmentation of 4D DCE-MRI Renal Studies ...... 2071 Borys Shuter, Voreak Suybeng, David A. Stringer, Marica Cutajar, Thomas Dissing, Anni Eskild-Jensen, Michael Pedersen, Jørgen Frøkiær, Jens Christian Djurhuus, Ashraf Kassim, Shih-Chang Wang, Isky Gordon

DCE MRI Pixel-By-Pixel Quantitive Curve Pattern Analysis (CPA) ...... 2072 Junyu Guo, Wilburn E. Reddick

A Precise Model for Arterial Input Functions of First Pass DCE-MRI...... 2073 Jeiran Jahani, Glyn Johnson

Orthogonal Diffusion Anisotropy Measurements in the Dorsal Third Ventricle of Adult Rat Brain Reveal Cerebrospinal Fluid Flow...... 2074 Laura Nieto-Charques, Pilar López-Larrubia, Sebastián Cerdán

Deletion of the Brain-Specific Link Protein BRAL-1 Facilitates Extracellular Diffusion in the Mouse Corpus Callosum...... 2075 Ivan Vorisek, Lydia Vargova, Lesia Dmytrenko, Yoko Bekku, Toshitaka Oohashi, Eva Sykova,

In Vivo Diffusion Tensor Magnetic Resonance Imaging and Fiber Tracking of the Mouse Brain ...... 2076 Laura-Adela Harsan, Dominik Paul, Susanne Schnell, Bjorn W. Kreher, Juergen Hennig, Jochen F. Staiger, Dominik von Elverfeldt

Diffusion Tensor Image Guided Histological Assessment of a Kainic Acid Rat Epilepsy Model Ex Vivo Utilizing Tract-Based Spatial Statistics Analysis...... 2077 Alejandra Sierra, Kimmo Lehtimäki, Teemu Laitinen, Jari Nissinen, Asla Pitkänen, Olli Gröhn

MRI Evaluation of Selective Disruption of the Blood-Brain Barrier by Photochemical Internalization...... 2078 Michelle Zhang, Steen J. Madsen, Henry Hirschberg, H Michael Gach

Crossing Fibers in Lateral White Matter of the Cervical Spinal Cord Detected with Diffusion MRI in Monkey Postmortem ...... 2079 Henrik Lundell, Tim Dyrby, Maurice Ptito, Jens Bo Nielsen

Comparison of Cerebral Blood Flow as Measured by Arterial Spin Labeling and Cerebral Blood Volume as Measured by Micro-CT Imaging Over Regions of the Mouse Brain ...... 2080 Brige Paul Chugh, Jason P. Lerch, Lisa X. Yu, R Mark Henkelman, John G. Sled

Temporal Tissue Assessment in Non-Human Primate Cerebral Ischemia Using Diffusion-Weighted MR Imaging and ISODATA Cluster Analysis ...... 2081 Mark J.R.J. Bouts, Ona Wu, Rick M. Dijkhuizen, Alex J. de Crespigny, Helen E. D'Arceuil,

Cerebral Hypoxia-Ischemia in Neonates as a Model of Ischemic Injury to Study MR Diagnosis of Descending Corticospinal Tract Degeneration ...... 2082 Sanju Lama, Min Qiao, Amy Ng, Delphi Barua, Dave Kirk, Tad Foniok, Ursula Irene Tuor,

DTI Eigenvalues in Grey Matter: A Songbird's Perspective...... 2083 Geert De Groof, Marleen Verhoye, Alexander Leemans, Marcel Eens, Veerle M. Darras, Annemie Van der Linden

ABCDEFGHI: Anatomic Basis Construction for Dynamic Enhancement Following Gadolinium CHelate Injection ...... 2084 Dustin K. Ragan, James A. Bankson

Physiological Motion Artifact Correction in Segmented DTI Measurement of Anesthetized Non-Human Primates...... 2085 Shiliang Huang, Xiaodong Zhang

Diffusion Tensor Imaging Reveals White and Gray Matter Modifications After Low Dose 56Fe Irradiation ...... 2086 Lei Huang, Shu-Wei Sun, Sheng-Kwei Song, Peter Hayes, Andre Obenaus,

Magnetic Resonance Techniques Applied to the Study of Mouse Brain Complications in Sepsis...... 2087 Philippe Garteiser, Sabrina Doblas, Fernando A. Bozza, Marcus F. Oliveira, Rebecca Cranford, Debra Saunders, Inna Jones, Rheal A. Towner, Hugo C. Castro-Faria-Neto

MRI Techniques to Measure rCBF in Experimental Cortical Impact Injury in Mice ...... 2088 Danielle Christa Brink, Brittany Renshaw Bitner, Leela Cherian, Robia G. Pautler, Claudia S. Robertson

Multi-Slice Absolute Cerebral Blood Volume Quantification on Animal Model Using a Hybrid Method of Vascular Space Occupancy and Susceptibility Effect of MION...... 2089 Chien-Chung Chen, Young Ro Kim, Yi-Chun Wu, Chou-Ming Cheng, Tzu-Chen Yeh, Fu-Nien Wang

Diffusion Tensor Tractography Aids in Anatomical Phenotyping ...... 2090 Jacob Ellegood, Ameet S. Sengar, Michael W. Salter, Sean E. Egan, Jason P. Lerch, R Mark Henkelman

Delayed Arrival of Arterial Blood Measured with Arterial Spin Labeling in Patients with a Symptomatic Carotid Artery Stenosis...... 2091 Reinoud Pieter Harmen Bokkers, H. Bart van der Worp, Willem P. Mali, Jeroen Hendrikse

Characterising the Origin of the Arterial Spin Labelling Signal in MRI Using a Multi-Echo Acquisition Approach...... 2092 Jack A. Wells, Mark F. Lythgoe, Mankin Choy, David Gadian, Roger Ordidge, David L. Thomas

Reliable Isolation of the Intravascular Contribution in Arterial Spin Labelling MRI ...... 2093 Michael A. Chappell, Bradley J. MacIntosh, Nicola Filippini, Matthias Günther, Clare E. Mackay, Peter Jezzard, Mark W. Woolrich

Optimization and Implementation of Vessel Suppression Preparation for ASL MRI...... 2094 Weiying Dai, Philip M. Robson, Ajit Shankaranarayanan, David C. Alsop,

Dispersion of a Short ASL Bolus Along the Arterial Tree...... 2095 Matthias Günther

Benefits of Short Bolus ASL...... 2096 Matthias Günther

Theoretical and Experimental Comparison of Different Techniques for Continuous Arterial Spin Labelling ...... 2097 Rolf Pohmann, Juliane Budde, Edward Auerbach, Gregor Adriany, Kamil Ugurbil

ASL Optimization for Hippocampus Physostigmine Challenge Perfusion Study ...... 2098 Xiufeng Li, Subhendra Sarkar, David M. Buhner, Robert W. Haley, Richard W. Briggs,

Modulated Dual Saturation Pulse Trains for FAIR Studies of Cerebellum Perfusion ...... 2099 Xiufeng Li, Subhendra Sarkar, Robert W. Haley, Richard W. Briggs,

Correcting for Off-Resonance Induced Degradation of Inversion Efficiency in Pseudo-Continuous ASL ...... 2100 Hesamoddin Jahanian, Luis Hernandez-Garcia, Douglas C. Noll,

Off-Resonant Artifact Correction of RF Pulse Concatenation for Blood Flow Imaging Applications ...... 2101 Cheng Ouyang, Luis Hernandez, Brad P. Sutton,

Continuous Arterial Spin Labeling at 9.4T: How Long to Label?...... 2102 Hanbing Lu, William Rea, Elliot A. Stein, Yihong Yang

Regional White Matter Perfusion Measurement Using an Optimized Pseudo-Continuous ASL MRI...... 2103 Kun Lu, Thomas T. Liu, Eric C. Wong, Youngkyoo Jung

Optimization of the Encoding Scheme for Improved SNR Efficiency in Vessel Encoded Pseudo-Continuous ASL...... 2104 Jia Guo, Eric C. Wong

A Method for Automatic Selection of the Labeling Slabs in Regional Arterial Spin Labeling ...... 2105 Ina Kompan, Matthias Günther, Johannes Heitz

Reproducibility of Flow Territories Defined by Plannings-Free Vessel Encoded Pseudo-Continuous Arterial Spin Labeling ...... 2106 Sanna Gevers, Aart J. Nederveen, Reinoud P.H. Bokkers, Jeroen Hendrikse, Dennis A. Kies, Wouter M. Teeuwisse, C.B. Majoie, Matthias J.P. van Osch

Within and Between Session Reproducibility of MR Perfusion Using PICORE Q2TIPS at 3T...... 2107 Yang Wang, Andrew J. Saykin, Chen Lin, Kristine M. Mosier, Andrew J. Kalnin, Josef Pfeuffer

Double Acquisition Background Suppressed (DABS) FAIR at 3T and 7T: Advantages for Simultaneous BOLD and CBF Acquisition ...... 2108 Roman Wesolowski, Penny A. Gowland, Susan T. Francis

Background Suppression in Multi Slice Arterial Spin Labeling...... 2109 Wouter M. Teeuwisse, Maarten J. Versluis, Mark A. van Buchem, Matthias J.P. van Osch,

Continuous Arterial Spin Labeling by a Separate Neck Coil with Inversion-Recovery Suppression of Static Tissue Signals (ir-cASL) ...... 2110 Qiang Shen, Timothy Q. Duong

Improved Detection and Estimation of Perfusion Using High Spatial Resolution ASL at 7T...... 2111 Emma Louise Hall, Roman Wesolowski, Penny A. Gowland, Susan T. Francis

Single Pair Arterial Spin Labeling Imaging ...... 2112 Jiabao He, Andrew M. Blamire

Comparison of Perfusion Values Obtained by Single Subtraction and Multiple Subtraction Strategies in ASL...... 2113 Onur Ozyurt, Alp Dincer, Cengizhan Ozturk

Comparison of Breath Holding Techniques for the Calibration of fMRI Measurements of Oxygen Metabolism ...... 2114 Peter Roberts, Peter Jezzard, Daniel Bulte

Measuring Absolute Arteriolar Cerebral Blood Volume (CBVa) in Human Brain Gray Matter (GM) Without Contrast Agent...... 2115 Jun Hua, Qin Qin, James J. Pekar, Peter CM van Zijl

3D Balanced SSFP Imaging of Arterial Arrival Time and Perfusion in Abdominal Organs Using Arterial Spin Labeling ...... 2116 Philip M. Robson, Weiying Dai, Ajit Shankaranarayanan, David C. Alsop

Assessment of Retinal and Choroidal Vascular Reactivity in Humans with Arterial Spin Labeling Perfusion Imaging ...... 2117 Nasim Maleki, David C. Alsop, Weiying Dai, Chris Hudson, David Mikulis, Jay Han, Joseph A. Fisher,

Layer-Specific Blood Flow MRI of the Mouse Retina...... 2118 Eric Raymond Muir, Timothy Q. Duong

Assessment of Calf Perfusion Kinetics in Response to Exercise and Ischaemia Using Q2TIPS-Arterial Spin Labelling Method...... 2119 Elina Raja Ahmad, Laura Michelle Parkes, Graham J. Kemp

Comparing Kidney Perfusion Using Arterial Spin Labeling and Microsphere Methods in an Interventional Swine Model ...... 2120 Nathan Artz, Andrew Wentland, Elizabeth Sadowski, Zhifei Wen, Thomas Grist, Arjang Djamali, Sean Fain,

ASL-FAIR Technique Optimization for Measuring Kidney Perfusion in Native and Transplanted Kidneys...... 2121 Nathan Artz, Zhifei Wen, Yin Huang, Sean Fain,

Perfusion Imaging of Inflammatory Thyroid Diseases Using an Arterial Spin Labeling Technique...... 2122 Christina Schraml, Karsten Müssig, Petros Martirosian, Nina F. Schwenzer, Andreas Boss, Claus D. Claussen, Hans U. Häring, Bernd Balletshofer, Fritz Schick

A Novel Technique for Functional MRI in Regions of Magnetic Field Inhomogeneity – Z-Shim Asymmetric Spin- Echo (ASE) Spiral...... 2123 Kimberly D. Brewer, Ryan CN D'Arcy, Chris V. Bowen, Steven D. Beyea,

Combined Gradient- And Spin-Echo EPI Acquisition Technique for High-Resolution fMRI ...... 2124 Heiko Schmiedeskamp, Samantha J. Holdsworth, Stefan Skare, Rexford David Newbould, Gary H. Glover, Roland Bammer

Comparison of Volume-Selective z-Shim and EPI with an fMRI Memory Task...... 2125 Hu Cheng, Srikanth Padmala, Rena Fukunaga

Unaliasing of Multiband Multislice EPI and GRE Imaging with GRAPPA ...... 2126 Steen Moeller, Essa Yacoub, Eddie Auerbach, Cheryl Ohlman, Kamil Ugurbil

A Method to Increase Temporal Resolution in 3D-EPI fMRI Using UNFOLD...... 2127 Onur Afacan, W. Scott Hoge, Dana H. Brooks, Jing Yuan, Ming-Long Wu, Lawrence P. Panych, Istvan Akos Morocz

Isotropic Sub-Millimeter fMRI of V5 in Human at 7T...... 2128 Robin Martin Heidemann, Robert Trampel, Dimo Ivanov, Fabrizio Fasano, Josef Pfeuffer, Robert Turner

Fat Suppression with Low SAR for SE EPI fMRI at 7T ...... 2129 Dimo Ivanov, Andreas Schäfer, Markus Streicher, Robert Trampel, Robert Turner

Multiple Area B1 Shimming: An Efficient, Low SAR Approach for T2-Weighted fMRI Acquired in the Visual and Motor Cortices of the Human Brain at Ultra-High Field ...... 2130 Pierre-Francois Van de Moortele, Eddie Auerbach, Kamil Ugurbil, Johannes Ritter

A Multi-Resolution Comparison of Single-Shot EPI, 3DFFE and PRESTO for fMRI at 7T...... 2131 John A. Sexton, John C. Gore, James Chris Gatenby,

Comparison of Single-Shot 2D EPI and Segmented 3D EVI Acquisition for fMRI at 7T ...... 2132 Wietske van der Zwaag, Tobias Kober, Jose Pedro Marques, Gary Glover, Rolf Gruetter, Gunnar Krueger

Inner Volume BOLD-fMRI at Ultra-High Spatial Resolution...... 2133 Patrick Michael Heiler, Simon Konstandin, Lothar Rudi Schad

Bridging the Gaps: High-Resolution Visual Field Mapping Using Passband b-SSFP fMRI...... 2134 Jin Hyung Lee, Gary H. Glover, Dwight G. Nishimura, John M. Pauly, Mark Schira

Pass-Band Balanced SSFP fMRI at 7 Tesla...... 2135 Jongho Lee, Masaki Fukunaga, Jeff H. Duyn

Monte Carlo Simulations of Phase Cycled pbSSFP fMRI Acquisitions...... 2136 Steven Patterson, Steven Donald Beyea, Chris Van Bowen,

Interleaved Spiral In/Out b-SSFP Acquisition for Functional Imaging ...... 2137 Anna Leigh Rack-Gomer, Giedrius Buracas, Youngkyoo Jung, Thomas T. Liu,

Spatial and Spectral Analysis for a Radial Sapmling Balance SSFP for fMRI...... 2138 Ray F. Lee, Jian Xu, Karthik Prabhakaran, Michael Arcaro

Measuring Task-Modulated Contrasts by Transition-Band bSSFP fMRI: A Rate-Dependence Study of Human Visual Cortical Response ...... 2139 Yi-Lu Tsai, Teng-Yi Huang

Distinguishing Pial and Laminar Gradient-Echo BOLD Signals at 7 Tesla...... 2140 Peter Jan Koopmans, Stephan Orzada, Markus Barth, David Gordon Norris,

Laminar Analysis of High Isotropic Resolution BOLD Activation with a Resolution Pattern Stimulus in Human V1 at 7T ...... 2141 Jonathan Rizzo Polimeni, Bruce Fischl, Douglas Greve, Lawrence Leroy Wald,

Functional MRI in the Rat Brain with Single-Shot Gradient Echo EPI at 16.4 T...... 2142 David Z. Balla, Hannes M. Wiesner, Gunamony Shajan, Rolf Pohmann

Large Influence of Flow-Related Contribution on fMRI Signal: A 9.4T Study Using Hypercapnia...... 2143 Xiao Wang, Xiao Hong Zhu, Yi Zhang, Wei Chen

Improved Separation of Tissue Oxygenation Extraction Fraction and Deoxygenated Blood Volume by Using the qBOLD Technique...... 2144 Jan Sedlacik, Jürgen R. Reichenbach, Claudia M. Hillenbrand

Modulating Brain Activity Via Multi-Echo fMRI Neurofeedback...... 2145 Mark Chiew, Audrey Yu Ching Kuo, Simon J. Graham,

White Matter fMRI: Exploring Functional Differentiation in the Corpus Callosum ...... 2146 Jodie R. Gawryluk, Kim Dillen, Kim D. Brewer, Erin L. Mazerolle, Steven D. Beyea, Ryan CN D'Arcy,

Real-Time Single-Trial BOLD Response Detection for Visual Attention at 7T...... 2147 Patrik Andersson, Jeroen C. Siero, Josien PW Pluim, Max A. Viergever, Nick F. Ramsey

Compensation of Non-T1-Related Artifacts in Variable TR fMRI at 1.5T...... 2148 Shuowen Hu, Olumide Olulade, Gregory G. Tamer, Wen-ming Luh, Thomas M. Talavage,

Hybrid Modelling of Axonal Magnetic Fields for Direct MR Neuronal Detection Estimation...... 2149 Syed Muhammad Anwar, Greg G. Cook, Li Sze Chow, Martyn N. Paley

Observation of Functional ADC Decrease in the Extravascular Tissue: A fMRI Study with Suppression of Intravascular Signal ...... 2150 Tao Jin, Ping Wang, Seong-Gi Kim,

How Vascular Effects Contribute to Heavily Diffusion-Weighted fMRI Signal...... 2151 Denis Le Bihan, Toshihiko Aso, Shin-ichi Urayama, Cyril Poupon, N Sawamoto, Kenji Aso, Hidenao Fukuyama

Monte-Carlo Simulations of BOLD Background Gradient Contributions in Diffusion-Weighted fMRI— Comparison of Spin Echo and Twice-Refocused Echo Sequences...... 2152 Andre Pampel, Thies H. Jochimsen, , Harald E. Moeller,

Signal Source in Heavily Diffusion-Weighted Functional MRI ...... 2153 Daigo Kuroiwa, Hiroshi Kawaguchi, Jeff Kershaw, Atsumichi Tachibana, Joonas Autio, Masaya Hirano, Ichio Aoki, Iwao Kanno, Takayuki Obata

Diffusion-Weighted TE-Dependent fMRI Signal in Rat Somatosensory Cortex at 7T...... 2154 Joonas Arttu Autio, Jeff Kershaw, Takayuki Obata, Sayaka Shibata, Daigo Kuroiwa, Iwao Kanno, Ichio Aoki

Evaluation of Diffusion fMRI (DfMRI) with Short Event Related Paradigms ...... 2155 Toshihiko Aso, Cyril Poupon, Shin-ichi Urayama, Hidenao Fukuyama, Denis Le Bihan,

Cortical Layer-Dependent BOLD and Arterial Blood Volume Responses Measured by MT-Varied BOLD fMRI ...... 2156 Tae Kim, Seong-Gi Kim,

Measurement of Absolute CBV Change During Brain Activation Using Grey Matter Nulled fMRI ...... 2157 Yuji Shen, Ida Mengyi Pu, Risto A. Kauppinen

A Theoretical and Experimental Investigation of Vascular-Space-Occupancy (VASO) Blood Nulling Times: Influence of Hematocrit and Oxygenation on Null Times and CBV Quantification ...... 2158 Manus Joseph Donahue, Stefan K. Piechnik, Rob Tijssen, Daniel Gallichan, Karla L. Miller, Peter Jezzard

Separation of the Vascular and Tissue Contributions to the T1rho Change Induced by Brain Activation ...... 2159 Tao Jin, Seong-Gi Kim,

Pseudo-Continuous Arterial Spin Labeling with Optimized Tagging Efficiency for Quantitative ASL fMRI...... 2160 Youngkyoo Jung, Anna Leigh Rack-Gomer, Eric C. Wong, Giedrius T. Buracas, Thomas T. Liu

High Temporal Resolution Functional MRA for Investigating the Neural Activity ...... 2161 Chan-A Park, Chang-Ki Kang, Seung-Taek Oh, Young-Bo Kim, Zang-Hee Cho

Quantification of Parenchymal T1 in the Activated Visual Cortex in Grey Matter Nulled and VASO fMRI Images ...... 2162 Yuji Shen, Ida Mengyi Pu, Risto A. Kauppinen, Xavier Golay

Stimulus Induced Modulation of Low Frequency Fluctuations in BOLD fMRI of the Rat ...... 2163 Waqas Majeed, Matthew Magnuson, Shella Keilholz

Voxel-Wise Regressor Selection for Physiological Noise Correction with RETROICOR ...... 2164 Mark Jenkinson, Rob Tijssen, Jonathan Brooks, Karla Miller

Evaluation of Cyclic and Global Retrospective Corrections of Physiological Signals on Activated fMRI ...... 2165 Arsène Longin Ella, Jochen Rick, Jürgen Hennig

Physiological Noise in GRAPPA fMRI Time-Series...... 2166 Christina Triantafyllou, Mattijs Elschot, Jonathan R. Polimeni, Lawrence L. Wald,

Real-Time Observation of Spatiotemporal Dynamics of Arterial Pulsatility with MR-Encephalography...... 2167 Jürgen Hennig, Thimo Grotz, Benjamin Zahneisen, Arsenne Ella, Maxim Zaitsev, Irina Mader, Andreas Harloff

Physiological Noise Characteristics in fMRI of the Rodent at 11.7T...... 2168 Daniel Kalthoff, Jörg Ulrich Seehafer, Dirk Wiedermann, Mathias Hoehn

Quantifying the Effects of CO2 on the Resting BOLD Signal...... 2169 Tingying Peng, Rami Niazy, Richard Wise, Stephen Payne

Effects of Sensitivity Encoding and Physiological Noise on Temporal Signal Stability and fMRI at 7T ...... 2170 John A. Sexton, James Chris Gatenby, John C. Gore,

B0 Dependence of Physiological Noise in BOLD fMRI...... 2171 Tomas Jonsson, Terri Lindholm, Pierre Vestman, Maria Kristoffersen Wiberg, Jerzy Bodurka, Tie -Qiang Li

Physiological Origin of Low Frequency Drift in BOLD fMRI...... 2172 Lirong Yan, Yan Zhuo, Yongquan Ye, Sharon Xie, Jing An, Geoffrey Aguirre, Jiongjiong Wang

Characterizing Physiological Noise in the Brainstem: Passband SSFP Vs. GRE-EPI...... 2173 Rob Hendrikus Tijssen, Mark Jenkinson, Peter Jezzard, Karla Loreen Miller

The Use of Neurofeedback with Real-Time Functional MRI to Suppress Physiological Noise...... 2174 Jerzy Bodurka, Javier Gonzalez-Castillo, Peter Bandettini,

BOLD Physiological Noise Reduction Using Spatio-Spectral-Temporal Correlations with NIRS ...... 2175 Douglas N. Greve, Daniel Goldenholz, Gayatri Kaskhedikar, Jonathan Polimeni, Bruce Fischl, Lawrence L. Wald, Bruce Rosen, Christina Triantafyllou, David Boas

Relationship Between Respiratory Variations and End-Tidal CO2 in BOLD fMRI Physiological Noise...... 2176 Catie Chang, Gary H. Glover,

Reduction of Physiological Noise Effects in fMRI Phase Time Series...... 2177 Gisela E. Hagberg, Marta Bianciardi, Valentina Brainovich, Bruno Maraviglia

Spatiotemporal Investigation of the fMRI Response to Brief Somatosensory Stimulation in Awake Marmosets...... 2178 Yoshiyuki Hirano, Junjie V. Liu, Bojana Stefanovic, Afonso C. Silva

75 µm High-Resolution Parallel Imaging GE-EPI BOLD fMRI in Rats at 11.7 Tesla: New Insights Into Cortical and Thalamic Micro-Structures ...... 2179 Joerg Ulrich Seehafer, Tom Geraedts, Mathias Hoehn

Cortical Boundaries Revealed by T1 Mapping: Comparison with fMRI in Awake Marmosets ...... 2180 Junjie V. Liu, Nicholas A. Bock, Yoshiyuki Hirano, Afonso C. Silva

Neurophysiological Underpinnings of Ketamine-Induced Negative BOLD Response...... 2181 Naranjargal Dashdorj, Mirjam I. Schubert, Malcolm Prior, Rob Mason, Dorothee Auer

Gradient-Echo and Spin-Echo BOLD fMRI of Rat Spinal Cord – Insight Into Its Hemodynamic Response to Neuronal Activity...... 2182 Fuqiang Zhao, Denise Welsh, Xiangjun Meng, Mangay Williams, Jacquelynn J. Cook, Alise S. Reicin, Richard Hargreaves, Donald S. Williams

Simultaneous fMRI and Field Potential Measurements of Epileptic Seizures in Rat Using RASER Pulse Sequence ...... 2183 Antti Markku Airaksinen, Juha-Pekka Niskanen, Joanna Katariina Huttunen, Ryan Chamberlain, Michael Garwood, Asla Pitkanen, Olli Grohn

Comparison of Functional Activation in the Temporal Lobe of Awake and Anesthetized Monkeys...... 2184 Jozien Goense, Hellmut Merkle, Nikos Logothetis,

Assessment of Rat Barrel Cortex BOLD Responses After Trigeminal Nerve Stimulation on the Linearity of BOLD fMRI Changes Against Neuronal Activity in the Barrel Cortex...... 2185 Nathalie Just, Stephane Germain, Martin Lauritzen, Rolf Gruetter,

Unexpected BOLD Behavior at 11.7 Tesla: A Comparison of Experimental Data with the Integrative BOLD Signal Model ...... 2186 Joerg Ulrich Seehafer, Kamil Uludag, Daniel Kalthoff, Tracy Deanne Farr, Mathias Hoehn

High Resolution BOLD-fMRI of the Auditory System in Rats...... 2187 Xin Yu, Artem Goloshevsky, Stephen Dodd, Afonso Silva, Alan Koretsky

Multi-Parametric Classification of fMRI-Activated Voxels Using Venous Vessel-Size, BOLD Latency and Susceptibility-Weighted Imaging...... 2188 Thies H. Jochimsen, Harald E. Möller

Feasibility of Detecting Differential Layer Specific Activations in Humans Using SE BOLD fMRI at 7 T ...... 2189 Essa Yacoub, Kâmil Ugurbil, Cheryl A. Olman

High Resolution Auditory fMRI at 7 T...... 2190 Wietske van der Zwaag, Eleanora Fornari, Philippe Maeder, Rolf Gruetter,

Latency and Echo-Time Dependence of the GRE-BOLD Signal in High-Resolution fMRI...... 2191 Stefan Hetzer, Toralf Mildner, Thies H. Jochimsen, Karsten Müller, Torsten Schlumm, Harald E. Möller

On the Cross-Modal Relationship Between fMRI and EEG ...... 2192 Zhongming Liu, Nanyin Zhang, Cristina Rios, Lin Yang, Wei Chen, Bin He

A Comparison of Quantitative Perfusion Measurements and MEG Phenomena...... 2193 Claire Stevenson, Matthew Brookes, Peter Morris, Susan Francis

A Comparison of Source Localisation Techniques in Concurrent EEG/fMRI ...... 2194 Matthew J. Brookes, Karen J. Mullinger, Gerða Björk Geirsdóttir, Claire M. Stevenson, Richard Bowtell, Peter G. Morris

Simultaneous EEG/fMRI Phantom Experiments with a Realistic Neuronal Signal...... 2195 Gerða Björk Geirsdóttir, Matthew J. Brookes, Karen J. Mullinger, Winston X. Yan, Peter G. Morris, Richard W. Bowtell

Visual BOLD-fMRI with 32 Channel Phased-Array Coil at 3.0T MRI System: Comparison with 12 Channel Coil ...... 2196 Jianqi Li, Lijia Wang, Yi Wang,

Dependencies of the Negative BOLD Signal in Primary Somatosensory Cortex on Stimulation Intensity and Duration...... 2197 Katharina Schaefer, Henrik Bo Wiberg Larsson, Martin Lauritzen,

Further Evidence of Initial BOLD Dip Across Cortico-Thalamic Visual Network During Visual Stimulation ...... 2198 Nanyin Zhang, Xiao-Hong Zhu, Yi Zhang, Wei Chen

Integrated Magnetic Field Variation Correction for Quantitative fMRI ...... 2199 John David Dickson, Guy B. Williams, Sally Georgia Harding, Thomas Adrian Carpenter, Richard E. Ansorge

Susceptibility Artefacts in Experiments Involving Changes in Inspired Oxygen Level...... 2200 Nicholas Paul Blockley, Ian D. Driver, Susan T. Francis, Joseph A. Fisher, Penny A. Gowland

SNR Optimization of MION fMRI in the Anaesthetized Monkey Using an 8-Channel PA-Coil and Accelerated Imaging ...... 2201 Thomas Janssens, Wim Vanduffel, Hauke Kolster

Modeling the Effect of Changes in Arterial Blood Volume on the BOLD Signal ...... 2202 Richard Buxton

Quantitative Combined ASL/BOLD Imaging: Implications for the Interpretation of the BOLD Post-Stimulus Undershoot ...... 2203 Valerie Griffeth, Aaron Simon, Joanna Perthen, Richard Buxton

Balloon Modeling of BOLD Responses in Children with Sickle Cell Anemia (SCA) ...... 2204 Robert Ogg, Ping Zou, Winfred Wang, Russel Ware, Kathleen Helton

Theoretical Prediction of Parameter Stability in Quantitative BOLD MRI: Dependence on SNR and Sequence Parameters ...... 2205 Maja Cornelia Sohlin, Lothar R. Schad

Comparison of Methods Used in Calibrated fMRI ...... 2206 Jerod Michael Rasmussen, Sumiko Abe, Liv C. McMillan, Josef Pfeuffer, Jessica Turner

Calibration of ASL Quantification Based on Hypercapnia and Sensory Motor Activation...... 2207 Sumiko Abe, Jerod Michael Rasmussen, Jessica Turner, L. Ch McMillan, Josef Pfeuffer, F. Birn

Validation of Optical Measurements of Cerebral Blood Flow and Volume with SPION and ASL fMRI: Implications for CMRO2 Changes During Hypercapnia ...... 2208 Stefan A. Carp, David A. Boas, Maria A. Franceschini, Bruce Ro Rosen, Young Ro Kim

The BOLD-Specific Flow-Volume Relationship During Hypercapnia and Hypocapnia ...... 2209 Jean J. Chen, G. Bruce Pike

T2 Responses in Grey Matter Nulled and VASO fMRI Images During Visual Stimulation in Hypoxic Hypoxia...... 2210 Yuji Shen, Ida Mengyi Pu, Y-C L. Ho, R Vidyasagar, Xavier Golay, Risto A. Kauppinen

Vasoreactivity Mapping Using Dynamic (C)O2 Enhanced MRI...... 2211 Stefanie Remmele, Julien Sénégas, Andreas Müller, Ingobert Wenningmann, Frank Träber, Hans Clusmann, Hannes Dahnke, Jürgen Gieseke, Sebastian Flacke, Winfried A. Willinek, Hans H. Schild, Petra Mürtz

The Ratio of CBF to CMRO2 Change with Brain Activation Increases with Increasing Stimulus Amplitude in Human Visual Cortex...... 2212 Christine Liang, Beau Ances, Joanna Perthen, Joy Liau, Giedrius Buracas, Susan Hopkins, Richard Buxton

Grey & White Matter Cerebrovascular Reactivity Response to Hypercapnia at 3 & 7T...... 2213 Ian David Driver, Nicholas P. Blockley, Susan T. Francis, Penny A. Gowland

Sinusoidally Modulated CO2 Stimulus Provides New Temporal Information on Cerebrovascular Reactivity ...... 2214 Nicholas Paul Blockley, Ian D. Driver, Susan T. Francis, Joseph A. Fisher, Penny A. Gowland

Feasibility of Estimating CBF/CMRO2 Coupling with a Calibrated-BOLD Method When the Driving Stimulus Is Unknown...... 2215 Aaron Simon, Valerie Griffeth, Joanna Perthen, Richard Buxton

An Alternative Technique for Measuring Cerebrovascular Reactivity; Comparing Cued Deep Breathing Hypocapnia with Inspiration of Carbon Dioxide...... 2216 Molly Gallogly Bright, Daniel P. Bulte, Peter Jezzard, Jeff H. Duyn

Dependence of BOLD Signal Amplitude on Baseline Venous Oxygenation and Cerebral Blood Flow ...... 2217 Joy Liau, Youngkyoo Jung, Anna Leigh Rack-Gomer, Thomas Liu

Inter-Subject Variability in Hypercapnic Normalization of the BOLD fMRI Response...... 2218 Joy Liau, Thomas Liu

Stress Testing the Brain at 7T with Breath Holding ...... 2219 Hans Hoogduin, Lars Bosboom, Mandy Conijn, Willem Mali, Peter Luijten

Breath Hold Task Significantly Correlates with Cognition Across Run and Visit ...... 2220 Jerod Michael Rasmussen, Sumiko Abe, Liv C. McMillan, Josef Pfeuffer, Jessica Turner

Study of Tricarboxylic Acid Cycle Flux Changes in Human Visual Cortex During Two-Hemifield Visual Stimulation with Different Stimulus Frequency Using In Vivo 1H-{13C} MRS and fMRI...... 2221 Fei Du, Malgorzata Marjanska, Xiao-Hong Zhu, Anjali Kumar, Elizabeth R. Seaquist, Kamil Ugurbil, Wei Chen

Nulling the CSF Signal in Quantitative fMRI...... 2222 John David Dickson, Guy B. Williams, Sally Georgia Harding, Thomas Adrian Carpenter, Richard E. Ansorge

Identification of Functional Changes in Early Alzheimer Disease Using Resting-State fMRI...... 2223 Xiaowei Song, Ryan D'Arcy, Andrew Ryan McIntyre, Alma Major, Steven Beyea, Kenneth Rockwood

Social Network Theory Applied to Resting-State fMRI Connectivity Data in the Analysis of Epilepsy Networks ...... 2224 Xiaohui Zhang, Fuyuze Tokoglu, R. Todd Constable

Functional Subdivision of Corticostriatal Interconnections Visualized by fMRI...... 2225 Julia M. Boehm, Veit Roessner, Peter Dechent, Juergen Baudewig

Impaired Thalamic Functional Connectivity in Vegetative State Detected by fcMRI ...... 2226 Jingsheng Zhou, Chunming Xie, Wenjun Li, Feng Ling, Shi-jiang Li

Disease State Prediction from Resting State Functional Connectivity...... 2227 R. Cameron Craddock, Paul Holtzheimer, Xiaoping P. Hu, Helen S. Mayberg

Interhemispheric Functional Connectivity of Primary Motor Cortex Is Reduced During Continuous Performance of an Unilateral Hand Task...... 2228 Michael Amann, Jochen Gunther Hirsch, Achim Gass

Spatiotemporally Coordinated Activation Detected During Apparent Rest in fMRI ...... 2229 Natalia Petridou, Cesar Caballero, Ian Dryden, Susan Francis, Penny Gowland

Temporal Frequency- And Time-Dependent BOLD and CBV fMRI Signals in Cat Visual Areas 17 and 18 ...... 2230 Cecil Chern-Chyi Yen, Mitsuhiro Fukuda, Seong-Gi Kim, \

Measures of Resting-State BOLD Connectivity Exhibit an Inverse Dependence on Baseline CBF ...... 2231 Anna Leigh Rack-Gomer, Joy Liau, Thomas T. Liu,\

Pharmacological Challenge with the Opioid Analgesic Buprenorphine, But Not Placebo, Enhances Resting-State Functional Connectivity in the Pain Processing Network...... 2232 Alexandre Coimbra, Dai Feng, Adam Schwarz, Jaymin Upadhyay, Lino Becerra, Richard Baumgartner,\

Low-Frequency Respiration Related Signals in Resting State fMRI: A Comparison of End-Tidal CO2 and Respiration Volume Per Time...... 2233 Kevin Murphy, Rami K. Niazy, C. John Evans, Richard G. Wise

Static and Dynamic Characteristics of Cerebral Blood Flow During the Resting State ...... 2234 Qihong Zou, Changwei Wesley Wu, Elliot A. Stein, Yufeng Zang, Yihong Yang

Manipulation of BOLD Resting-State Functional Connectivity and Task Related BOLD fMRI Signal by Different Anesthetic Dosages ...... 2235 Anthony G. Hudetz, Bharat B. Biswal, Rupeng Li, James S. Hyde, Christopher Paul Pawela

Spatial and Subject Variability of Long-Term Respiration Effects in fMRI ...... 2236 Jaemin Shin, Richard Cameron Craddock, Helen Mayberg, Xiaoping Hu

Mapping Functional Connectivity Based on Synchronized CMRO2 Fluctuations During Resting State ...... 2237 Changwei Wesley Wu, Hong Gu, Hanbing Lu, Elliot A. Stein, Jyh-Horng Chen, Yihong Yang

Mapping Functional Connectivity in the Anesthetized Rat Using CBV Vs BOLD ...... 2238 Matthew Evan Magnuson, Waqas Majeed, Shella Keilholz

Resting-State Functional Connectivity of Primary Somatosensory Cortices in Urethane Anesthetized Rats...... 2239 Juha-Pekka Niskanen, Antti Markku Airaksinen, Joanna Katariina Huttunen, Olli Heikki Gröhn fMRI and Granger Causality Modeling Combined to Study Brain Functional Connectivity Under Anesthesia ...... 2240 Benito de Celis Alonso, Elke Metzger, Marina Sergejeva, Andreas Hess

Meta-Analyses of Mathematical Calculation and Default-Mode Networks: Impact on BOLD-Based fMRI ...... 2241 Tzu-chen Yeh, Tzuyi Hong, Wen-Jui Kuo, Jun-Ren Lee, Chou-Ming Cheng, Jen-Chuen Hsieh, Low-Tone Ho

The Dependence of ICA Decomposition on Dimensionality in Functional Connectivity ...... 2242 Erik B. Beall, Katherine A. Koenig, Mark J. Lowe

Whole Brain Clustering on the Basis of Resting-State fMRI Data...... 2243 Hubert Martinus Fonteijn, David Gordon Norris

Effects of Transverse Relaxation on Functional Connectivity of Default Mode Network ...... 2244 Changwei Wesley Wu, Jyh-Horng Chen, Elliot A. Stein, Yihong Yang

Phase Regression and Dynamic B-Field Correction Reduce Global Time Series Correlations and Increase Functional Correlations...... 2245 Andrew S. Nencka, Andrew D. Hahn, Daniel B. Rowe

Test-Retest Reliability of Functional Motor Connectivity...... 2246 Alan B. McMillan, Steve Roys, Neha Shah, Anindya Roy, Joel D. Greenspan, Rao P. Gullapalli

Template Free Identification of Resting State Networks Based Independent Component Analysis ...... 2247 Veronika Schoepf, Christian H. Kasess, Andreas Weissenbacher, Rupert Lanzenberger, Christian Windischberger, Ewald Moser

Functional Connectivity Mapping in the Rat Brain Using Spin-Echo EPI ...... 2248 Waqas Majeed, Matthew Magnuson, Shella Keilholz

Exploration of Functionally Connected Networks in the Rat Brain Using Multislice fMRI...... 2249 Waqas Majeed, Matthew Magnuson, Shella Keilholz

The Effect of Light and Eyes Opening on Spontaneous Activity in the Visual Cortex ...... 2250 Marta Bianciardi, Masaki Fukunaga, Jacco A. de Zwart, Jeff H. Duyn

Simultaneous EEG & fMRI: Positive Correlations to Frontal Theta Power ...... 2251 Allen T. Newton, Victoria L. Morgan, John C. Gore

Studying Spontaneous Brain Activity Using EEG-fMRI and Event-Related ICA ...... 2252 Richard Masterton, David Abbott, Graeme Jackson

State-Dependent, Widespread Correlation of Neural and fMRI Endogenous Fluctuations in the Awake Monkey...... 2253 Marieke L. Scholvinck, Frank Q. Ye, Charles Zhu, Alexander Maier, Jeff H. Duyn, David A. Leopold

Deconvolved fMRI Correlates with Source-Localised MEG as a Function of Neural Frequency Oscillation ...... 2254 Johanna M. Zumer, Claire M. Stevenson, Matthew J. Brookes, Sue T. Francis, Peter G. Morris

The Relationship Between 7T fMRI BOLD and MEG Derived γ Activity...... 2255 Claire Stevenson, Matthew Brookes, Peter Morris

Correspondence Between Resting State Networks and EEG-Correlated fMRI Maps...... 2256 Rami Khalil Niazy, Gaynor A. Smith, C John Evans, Richard G. Wise

Correlation of Fluctuations in Simultaneously Recorded VEP and BOLD fMRI ...... 2257 Dan Fuglø, Henrik Pedersen, Henrik Bo Wiberg Larsson

Exploring the Relationship Between Driven Neuronal Activity and the BOLD Response to Visual Stimulation Relative to an Individual’s Alpha Frequency...... 2258 Karen J. Mullinger, Peter F. Liddle, Richard W. Bowtell

Validation of Awake Rat Model for Measures of Pain and Analgesia with fMRI...... 2259 Lino Becerra, Pei-Ching Chang, James Bishop, Eric Crown, Yang Tsai, Mark Urban, Michael Klimas, Richard Hargreaves, Smriti Iyengar, Rosa Maria Simmons, Steve C. Peters, Adam James Schwarz, David Bleakman, David Borsook

Opposite Parietal and Midbrain BOLD Patterns During Inflammatory Pain in the Rat: A High-Field fMRI Study...... 2260 Ariel Graff-Guerrero, Juan Manuel Ortega-Legaspi, Camilo De la Fuente-Sandoval, Francisco Pellicer, Desiree López, Alvino Moreno, Rodrigo Martín, Sergio Solis, Silvia Hidalgo, Alfredo O. Rodriguez

Spin Versus Gradient Echo Sequence: What Is Better for Pain Research with Small Animal fMRI? ...... 2261 Lubos Budinsky, Silke Kreitz, Marina Sergejeva, Nicole Motzkus, Anna Pamberg, Andreas Hess

A Peripheral Nerve Repair Model Using fMRI in Rats ...... 2262 Maida A. Parkins, Rupeng Li, Hani S. Matloub, Ji-Geng Yan, James S. Hyde, Christopher P. Pawela

Assessing Alcohol-Induced Liver Damage in Chronic Alcoholic Rats by Gradient Echo fMRI...... 2263 Manfred Brauer, Melissa Yau, Leslie M. Foley

Potentiation of the Metabotropic Glutamate Receptor Subtype 2 Blocks Phencyclidine-Induced Brain Activation: A phMRI Study...... 2264 Nellie E. Byun, Elizabeth A. Hackler, Carrie K. Jones, Jason M. Williams, Malcolm Avison, P. Jeffrey Conn, John C. Gore,

The Effects of Methylphenidate on Resting-State Brain Activity in Normal Adults: An fMRI Study...... 2265 Biao Jiang, Yihong Zhu, Pingzhen Guo, Yichao Deng, Hongjian He, Feiyan Chen, Yufeng Zang

Anesthesia Effects on BOLD and rCBV Responses Induced by L-Tetrahydropalmatine...... 2266 Xiping Liu, Zheng Yang, Rupeng Li, Qian Yin, Shi-Jiang Li

Hyperalgesic Effects of Low Dose Lidocaine Detected by BOLD fMRI in Mice ...... 2267 Simone Claudia Bosshard, Christof Baltes, Hanns Ulrich Zeilhofer, Markus Rudin

Statistical Pitfalls in Pharmacological MRI...... 2268 Michael Luchtmann, Katja Jachau, Claus Tempelmann, Johannes Bernarding

Characterization of a 5-HT2C Antagonist Profile of Agomelatine Using Challenge phMRI in the Rat...... 2269 Inna Linnik, Shane McKie, Jennifer A. Stark, Simon Luckman, Bill Deakin, Steve R. Steve R. Williams

Quantification of Neural Activation in Spinal Cord by Blood Volume-Weighted fMRI on a Run-By-Run Basis – a Viable Pain Assay for Analgesics Development ...... 2270 Fuqiang Zhao, Mangay Williams, Denise Welsh, Xiangjun Meng, Amy Ritter, Catherine Abbadie, Jacquelynn J. Cook, Alise S. Reicin, Richard Hargreaves, Donald S. Williams

Imaging Brain Activity: Longitudinal fMRI in Mice Using Medetomidine Sedation ...... 2271 Joanna Magdalena Adamczak, Tracy Deanne Farr, Joerg Ulrich Seehafer, Mathias Hoehn

Effect of Isoflurane Anesthesia on BOLD Response to Somatosensory Stimulation: Results from fMRI Experiments in Conscious Rats...... 2272 Denise Welsh, Alexandre Coimbra, Andrew Danziger, Al Rauch, Christopher Regan, Joseph J. Lynch, Donald S. Williams

Functional MRI Reveals the Critical Role of Broca’s Area in Speech Sound Disorders ...... 2273 Xu Chen, Barbara Lewis, Amy Hansen, Lisa Freebairn, Jean Tkach,

Broca’s Area BA 45 Mediates the Cognitive and Emotional Interference Resolution in Healthy Adolescents ...... 2274 Adina Maria Mincic, Patricia A. McGrath, Karen D. Davis

Evaluation of Language Processing in fMRI at 7 T...... 2275 Nina Koschnicke, Stefan Maderwald, Jens Matthias Theysohn, Katja Großkurth, Mark E. Ladd, Elke Ruth Gizewski

Lateralization of the Mirror Neuron System During Observation and Execution of Object-Related Actions: A Functional Magnetic Resonance Study in Right and Left-Handed Subjects...... 2276 Monia Cabinio, Valeria Blasi, Marcella Montagna, Paola Borroni, Antonella Iadanza, Giuseppe Scotti, Andrea Falini, Gabriella Cerri

Diverting Attention Suppresses Human Amygdala Responses to Faces ...... 2277 Carmen Morawetz, Juergen Baudewig, Stefan Treue, Peter Dechent

Functional Connectivity of the Insula in Smokers...... 2278 Peter S. LaViolette, William Collier, M D. Verber, Kathleen M. Schmainda, L Piacentine, K L. Douville, S A. Claesges, S J. Durgerian, Alan S. Bloom

Neurofeedback Real-Time fMRI for the Regulation of Motor Areas in Chronic Stroke Patients...... 2279 Jong-Hwan Lee, Lee A. Kearse, Richard Hughes, Yi Tang, Lawrence P. Panych, Joel Stein, Ferenc A. Jolesz, Randie M. Black- Schaffer, Seung-Schik Yoo

Human MT Complex: Selectivity to Motion Flow Stimuli and to Retinotopic and Spatiotopic Input...... 2280 Laura Biagi, Sofia Crespi, Giovanni D'Avossa, Maria Concetta Morrone, Michela Tosetti

Acute Blockade of 5HT2a Receptors Reduces Orbitofrontal Cortex Response to Angry and Fearful Faces ...... 2281 Bettina Hornboll, Jon S. Wegener, Olaf B. Paulson, James B. Rowe, Gitte Moos Knudsen, Hartwig Siebner, Julian Macoveanu,

Modulation of the Brain Activities During 3D Object Perception from 2D Optic Flow ...... 2282 Sunao Iwaki, John W. Belliveau

Studying Familiarity of Different Stimulus Types...... 2283 Esin Karahan, Ozlem Ozmen Okur, Ozlem Alkan, Tulin Yildirim, Cengizhan Ozturk

Gender Differences in Correlations of Functional Brain Activation with Intelligence Factor Scores...... 2284 Emily Eaves, Cheuk Ying Tang, Johnny Ng, David Carpenter, David Schroeder, Chris Condon, Roberto Colom, Richard J. Haier

Neural Differences Between Intrinsic Motivation and Incentive Motivation...... 2285 Woogul Lee, Johnmarshall Reeve, Yiqun Xue, Jinhu Xiong

System for Computerized Writing and Drawing During fMRI...... 2286 Fred Tam, Nathan Churchill, Stephen C. Strother, Simon J. Graham

Functional Magnetic Resonance Imaging of Human Brain Exposed to a 60Hz, 1800µT Magnetic Field ...... 2287 Alexandre G. Legros, Julie Weller, John Robertson, Michael Corbacio, Daniel Goulet, Robert Stodilka, Frank S. Prato, Alex W. Thomas

Multimodality Imaging in Cerebro-Cerebeller Verbal Working Memory...... 2288 Wen-Yang Chiang, Jing-Syun Yu, Shen-Hsing Annabel Chen, Wen-Yih Isaac Tseng

Functional MRI Correlates with Self-Assessment of Pain Intensity and Reveals Effect of the Opioid Analgesic Buprenorphine on Brain Processing of Noxious Stimulation...... 2289 Alexandre Coimbra, Richard Baumgartner, Adam Schwarz, Jaymin Upadhyay, Julie Anderson, Jamie Knudsen, James Bishop, Gautam Pendse, Edward George, Sanjay Keswani, Brigette Robertson, Rudy Schrieber, Smriti Iyengar, Tom Large, David Bleakman, Richard Hargreaves, Lino Becerra, David Borsook

Two Local Constrained Canonical Correlation Analysis Methods for fMRI...... 2290 Mingwu Jin, Rajesh Nandy, Dietmar Cordes

Effectiveness of Gaussian Smoothing on Spatially Correlated Noise: A 3T Case Analysis ...... 2291 Mingwu Jin, Rajesh Nandy, Dietmar Cordes

Robust, Unbiased General Linear Model Estimation of phMRI Data in the Presence of Variance in the Temporal Response Profile...... 2292 Gautam Vithal Pendse, Adam James Schwarz, Richard Baumgartner, Alexandre Coimbra, David Borsook, Lino Becerra

A Stochastic Linear Model of Neurovascular Dynamics in the BOLD Signal ...... 2293 Leigh A. Johnston, Maria Gavrilescu, Eugene P. Duff, Gary F. Egan

Deconvolving Haemodynamic Response Function in fMRI Under High Noise by Compressive Sampling ...... 2294 Christine Law, Gary Glover

A Novel Test Statistic Allowing a General Linear Contrast Vector for Local Canonical Correlation Analysis in fMRI...... 2295 Mingwu Jin, Rajesh Nandy, Dietmar Cordes

A Quantitative Comparison of Different Group Analysis Methods in Dynamic Causal Modeling: Dependence on Noise and Inter-Subject Variability ...... 2296 Christian H. Kasess, Andreas Weissenbacher, Lukas Pezawas, Ewald Moser, Christian Windischberger

Elucidating the Impulse Response Function of SEEP Contrast in the Human Spinal Cord by Means of Event- Related Spin-Echo Spinal fMRI...... 2297 Chase R. Figley, Jordan K. Leitch, Celina Nahanni, Patrick W. Stroman

An Analytic Magnitude and Phase fMRI Activation Model Applied to ASL...... 2298 Daniel B. Rowe, Luis Hernandez-Garcia

Optimisation of Support Vector Machine Classifier Algorithms for Use as a Brain Computer Interface in Real- Time fMRI Applications...... 2299 Guy B. Williams

Granger Causality Via Vector Auto-Regression Tuned for fMRI Data Analysis...... 2300 Gang Chen, J. Paul Hamilton, Moriah E. Thomason, Ian H. Gotlib, Ziad S. Saad, Robert W. Cox

High Temporal Resolution Estimation of Hemodynamic Response from Event-Related fMRI...... 2301 Mark A. Smith, Mark J. Lowe

Towards Quality Control of Subject Movement in fMRI Studies ...... 2302 Daniel Cromb, Andy Simmons

Induced Correlation in fMRI Magnitude Data from k-Space Preprocessing ...... 2303 Daniel B. Rowe, Andrew S. Nencka

Development of the Expert System for Quantification of Brain Activation (QUBA) in fMR Images: Differential Activation Analysis...... 2304 Tae-Hoon Kim, Gwang-Woo Jeong, Byung-In Min, Hyeong-Jung Kim, Sundaram Thirunavukkarasu, Han-Su Baek, Gwang-Won Kim, Heoung-Keun Kang, Moo-Suk Lee

Shape Invariant Modelling of Trial Based fMRI Data ...... 2305 Kristoffer Hougaard Madsen, Lars Kai Hansen, Morten Mørup

Classification Technique to Detect Activation Patterns in Pain fMRI Data...... 2306 Loan Vo, Harish A. Sharma, Y. Michelle Wang, Dirk B. Walther, Arthur F. Kramer, William Olivero

Time Course Information Extracted by the Sliding Window Analysis Detected the Decrease of T-Values in Hippocampal Areas During a Paired Associative Learning of Novel Faces and Names...... 2307 Kayako Matsuo, Epifanio Tila Bagarinao, Tetsuya Iidaka, Akinori Takeda, Toshiharu Nakai

The Application of the Sliding Window Analysis: The Brain Location and the Window Width...... 2308 Kayako Matsuo, Epifanio Tila Bagarinao, Tetsuya Iidaka, Akinori Takeda, Toshiharu Nakai

An Efficient Global Clustering Algorithm for the Identification of Functional Connectivity from BOLD fMRI...... 2309 Andrew Ryan McIntyre, Xiaowei Song, Evangelos E. Milios, Malcolm I. Heywood, Alma Major, Ryan D'Arcy, Kenneth Rockwood

The Nintendo Wii Remote as an MR-Compatible Interface to Cognitive Studies Using fMRI ...... 2310 Jerod Michael Rasmussen, Karen Ayre Rasmussen

A Virtual Radial Arm Maze for the Study of Multiple Memory Systems ...... 2311 Dongrong Xu, Xuejun Hao, Zhishun Wang, Yunsuo Duan, Rachel Marsh, Shan Yu, Bradley S. Peterson

Optimalization of Event-Related fMRI Design for BOLD Deconvolution ...... 2312 Johan Martijn Jansma, Jacco A. de Zwart, Peter van Gelderen, Wayne C. Drevets, Maura L. Furey

Real-Time Rejection of Gradient and Pulse Related Artefact (GRA and PRA) from Electroencephalographic Signals Recorded During Functional Magnetic Resonance Imaging (fMRI) ...... 2313 Yves Leclercq, Andre Luxen, Evelyne Balteau, Pierre Maquet, Christophe Phillips

Analyzing Task Activated BOLD fMRI Signal Voxel Area and Intensity Measurements with Bootstrap Power Analysis...... 2314 Christopher Paul Pawela, B Douglas Ward, Rupeng Li, Bharat B. Biswal, James S. Hyde

Reverse BOLD Improves Efficiency for Brain Response to Faces ...... 2315 Christopher Glielmi, George A. James, Zhihao Li, Xiaoping Hu

Gradient Non-Linearity Correction Relocates Normalised Group Activation Hotspot...... 2316 Arnold Skimminge, Mark Schram Christensen

Background Suppression Does Not Reduce Physiological Noise in Myocardial ASL Perfusion Imaging ...... 2317 Zungho Zun, Eric C. Wong, Krishna S. Nayak

Assessment of Myocardial Blood Flow in Humans Using Arterial Spin Labeling: Feasibility and Noise Analysis...... 2318 Zungho Zun, Eric C. Wong, Krishna S. Nayak

Myocardial ASL Perfusion Imaging Using Pulsed 2D Tagging of the Proximal Aorta ...... 2319 Zungho Zun, Eric C. Wong, Krishna S. Nayak

Assessment of Myocardial Perfusion Reserve with Blood Oxygen Level-Dependent Cardiovascular Magnetic Resonance Imaging...... 2320 Jacqueline Allison Flewitt, Matthias Voehringer, Jordin Daniel Green, Matthias G. Friedrich

Blood Oxygen Level-Dependent Cardiovascular Magnetic Resonance Imaging (BOLD-CMR) in Assessment of Transmural Perfusion Effect...... 2321 Jacqueline Allison Flewitt, Matthias Voehringer, Jordin Daniel Green, Matthias G. Friedrich

Short Inversion Time Gadolinium-Enhanced Myocardial Infarct Imaging Yields Improved Infarct to Blood Contrast ...... 2322 James W. Goldfarb, Sheeba Arnold, Margeurite Roth

Myocardial Viability Imaging Using HYPR-Based MRI Techniques...... 2323 Orhan Unal, Julia Velikina, Kevin M. Johnson, Charles A. Mistretta

Validation of Cine-FLASH as a Method to Image Late Gd Enhancement in Mice...... 2324 Andrea Protti, Alexander Alexander Sirker, Tobias Schaeffter, Ajay Shah, Rene Botnar

Estimation of the Myocardial Extracellular Volume Fraction from Dynamic Contrast-Enhancement Measurements and Comparison with Partition Coefficient Measurements...... 2325 Michael Jerosch-Herold, Ray E. Hershberger, Craig Broberg

Intra-Individual Comparison of 0.1 mmol/kg Versus 0.2 mmol/kg Gadobutrol for Magnetic Resonance Late Enhancement Imaging at 3 Tesla...... 2326 Frank Grothues, Hagen Boenigk, Martin Kanowski, Joachim Graessner, Katrin Christel Sprung, Martin Rohrer, Ruediger Christian Braun-Dullaeus

Free-Breathing Semi-Automated Quantitation of Area-At-Risk Size in Patients with Acute Myocardial Infarction ...... 2327 Samuel Alberg Kock, Anders Koustrup Niemann, Jacob Thorsted Sørensen, Jens Flensted Lassen, Christian Juul Therkelsen, Hans Erik Bøtker, Torsten Toftegaard Nielsen, Won Yong Kim

Structural and Functional Consequences of Ischemia and Reperfusion in the Heart- A Long-Term Follow Up Via Cardiac MRI in a Rodent Model ...... 2328 Florian Andreas Bönner, Stefan Weber, Karl Friedrich Kreitner, Wolfgang Günther Schreiber, Georg Horstick

Observer Performance with State-Of-The-Art T2 Weighted Sequences (T2p ssSSFP, T2w ACUTE, T2 DB TIRM, T2 DB BLADE) for the Detection of Area-At-Risk (AAR) in Acute Coronary Syndromes (ACS) ...... 2329 Magalie Viallon, Nathan Mewton, Didier Revel, Peter Kellman, Pierre Croisille

Relationship of Infarct Size and Cardiac Functions in the Hyper-Acute Phase of Myocardial Ischaemia- Reperfusion in Rats ...... 2330 King Kenneth Cheung, Anthony Neil Price, Johannes Riegler, Roger J. Ordidge, Mark Francis Lythgoe

3D Black-Blood T1 Mapping of the Mouse Heart Using IntraGate FLASH and DESPOTI Analysis...... 2331 Bram Fransiscus Coolen, Tessa Geelen, Arno Nauerth, Larry de Graaf, Klaas Nicolay, Gustav J. Strijkers

Temporal Cardiac Manganese-Enhanced MRI with T1-Mapping in Mice Following Myocardial Infarction ...... 2332 Fang Liu, Ben Waghorn, Jimei Liu, Tom C. - C. Hu

Cardiac Function and Fat Composition in STZ-Induced Diabetic Rats...... 2333 Jun Lu, Beau Pontre, Stephen Pickup, Yee Soon Choong, Anthony Phillips, Hong Xu, Garth JS Cooper, Alistair Young

Preservation of Cardiac Function in Transient Receptor Potential V4 Knockout Mice After Myocardial Infarction Measured by Magnetic Resonance Imaging...... 2334 Gregory Turner, Weike Bao, Beat Jucker, Kevin Thorneloe, Robert Willette

Assessment of Left Ventricular Myocardial T1 Hyperintesity in Patients with Suspected Cardiac Amyloidosis Using MRI ...... 2335 Kirsi M. Taimen, MIchael C. Yang, Karin Dill, John Sheehan, James C. Carr

Pre-Contrast Imaging of the Area at Risk in Acute Myocardial Infarction: T2 Yields Higher Contrast Than T1 MRI ...... 2336 Anthony Homer Aletras, Peter Kellman, Li-Yueh Hsu, Daniel Groves, Robert F. Hoyt Jr. , Andrew Ernest Arai

Accurate Assessment of Myocardial Infarction in Mice Using 3D Inversion Recovery Gradient Echo MRI...... 2337 Steffen Bohl, Craig A. Lygate, Hannah Barnes, Debra Medway, Lee-Anne Stork, Jeanette Schulz-Menger, Stefan Neubauer, Juergen E. Schneider

Impact of Myocardial Infarct on Regional Left Ventricular Function ...... 2338 Ramsey Al-Hakim, James Sayre, Kalyanam Shivkumar, Paul Finn, Carissa Fonseca

Validation of Infarct Measurements by Inversion Recovery Delayed-Enhancement MRI During the Hyper-Acute Phase of Myocardial Infarction in Rats ...... 2339 King Kenneth Cheung, Anthony Neil Price, Roger J. Ordidge, Mark Francis Lythgoe

The Combination of Low Dose Dobutamine and Delayed Enhancement CMR Is More Predictive of Infarct Zone and Left Ventricular Functional Recovery Than Either Element Alone ...... 2340 Anne Elizabeth Scott, Scott Ian Kay Semple, Thomas W. Redpath, Graham S. Hillis

Myocardial Fat Deposition in Segements with Infarction Detected with Water-Fat Separation Imaging ...... 2341 James W. Goldfarb, Margeurite Roth, Jing Han

Myocardial T1, T2 and T2* Measurements for in Vivo Assessment of Iron Overload in Thalassemia...... 2342 Taigang He, John-Paul Carpenter, Guang-Zhong Yang, Dudley J. Pennell, David N. Firmin

Comparing in Vivo T2* and T2 Measurements in Tissues of Liver and Heart in Thalassemia ...... 2343 Taigang He He, Gillian C. Smith, Raad H. Mohiaddin, David N. Firmin, Dudley J. Pennell

Twelve Weeks of Chronic Mitral Regurgitation Alters Myocardial Structure as Measured by Diffusion Tensor MRI ...... 2344 Daniel Bruce Ennis, Tom C. Nguyen, Gabriel R. Barnard, Aki Itoh, Stefan Skare, Wolfgang Bothe, Neil B. Ingels, D C. Miller

Cardiac Diffusion Tensor Magnetic Resonance Imaging for High Resolution Reconstruction of Individual Whole Hearts...... 2345 Patrick William Hales, Fleur Mason, Rebecca Burton, Christian Bollensdorff, Martin Bishop, Gernot Plank, Peter Kohl, Jurgen Schneider

Temporal Changes in Diffusion Tensor Imaging Parameters in the Ex-Vivo Rat Heart ...... 2346 Patrick William Hales, Fleur Mason, Rebecca Burton, Christian Bollensdorff, Peter Kohl, Jurgen Schneider

Myocardial Vasculature: A Major Contributor to Cardiac MR Diffusion ...... 2347 MinSig Hwang, Melvin Clark, John R. Forder

Head to Head Comparison of Magnetic Resonance Imaging and Multidetector Computed Tomography in Assessing Long-Term Effects of Microembolization on Myocardial Viability, Perfusion and Function ...... 2348 Maythem Saeed, Alastair Martin, Marcus Carlsson

Sequential Change in Myocardial Perfusion in Ischemic Heart Disease Post Percutaneous Coronary Intervention: A Longitudinal Study Using First-Pass Contrast-Enhanced MRI...... 2349 Wan-Chen Shen, Mao-Yuan Marine Su, C-C Wu, Y-W Wu, W-C Chu, Wen-Yih Isaac Tseng

Patients with Pulmonary Arterial Hypertension Have a Lower Left Ventricular Myocardial Perfusion Reserve on Cardiac MR Adenosine Stress Perfusion Imaging Compared to Age Matched Healthy Controls...... 2350 Jan Skrok, Monda L. Shehata, Christopher Sibley, Thomas Goldstein, Kyle McCommis, Jie Zheng, Joao A. Lima, David A. Bluemke, Paul Hassoun, Jens Vogel-Claussen

Cold Pressor Test in MRI for Quantitative Myocardial Perfusion Imaging ...... 2351 Andreas Weng, Christian Oliver Ritter, Max Kowalski, Meinrad Joachim Beer, Dietbert Hahn, Herbert Köstler

Fully Automated Respiratory Motion Compensation in Myocardial Perfusion MRI Using Navigators...... 2352 Henrik Pedersen, Steffen Ringgaard, Won Yong Kim

Systolic 3D First-Pass Myocardial Perfusion MRI ...... 2353 Taehoon Shin, Padmini Varadarajan, Ramdas G. Pai, Gerald M. Pohost, Krishna S. Nayak

Stress Myocardial Perfusion MRI at 3.0T with Improved Spatial and Temporal Resolutions by Using B1- Insensitive Water-Suppression and k-t SENSE Acceleration ...... 2354 Shingo Kato, Hajime Sakuma, Shinichi Takase, Motonori Nagata, Nanaka Ishida, Kakuya Kitagawa, Masaki Ishida, Masaaki Ito, Makoto Obara, Kan Takeda

Myocardial Perfusion Imaging Using CAIPIRINHA Accelerated Multi-Slice Saturation Recovery TrueFISP ...... 2355 Daniel Stäb, Christian Oliver Ritter, Andreas Weng, Meinrad Joachim Beer, Marcel Gutberlet, Dietbert Hahn, Herbert Köstler

Unsupervised Inline Analysis of Cardiac Perfusion MRI...... 2356 Hui Xue, Sven Zuehlsdorff, Peter Kellman, Andrew Arai, Sonia Nielles-Vallespin, Christophe Chef D Hotel, Beatriz Paniagua, Christine Lorenz, Jens Guehring

Comparison of Myocardial Blood Flow Estimates from Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Four Quantitative Analysis Methods ...... 2357 Nathan A. Pack, Edward V.R. DiBella, Christopher J. McGann

Quantification of Myocardial Blood Flow in the Presence of Remaining Contrast Agent- A Simulation Study ...... 2358 Dirk Ernst Johannes Cleppien, Georg Horstick, Stefan Weber, Wolfgang Günther Schreiber

Comparison of the Quantitative First-Pass Myocardial Perfusion MRI with and Without Prospective Slice Tracking: Comparison Between Breath-Hold and Free-Breathing Condition ...... 2359 Dirk Ernst Johannes Cleppien, Georg Horstick, Nico Abegunewardene, Stefan Weber, Christian Ernst Mueller, Axel Heimann, Karl-Friedrich Kreitner, Oliver Kempski, Wolfgang Günther Schreiber

Quantitative Contrast-Enhanced Myocardial Perfusion MRI: Simulation of Bolus Dispersion in Constricted Vessels ...... 2360 Dirk Graafen, Kerstin Münnemann, Stefan Weber, Wolfgang Günther Schreiber

Model-Free Maximum Likelihood Deconvolution (MLD): A Novel Perfusion Analysis Method in MRI to Calculate Myocardial Blood Flow...... 2361 Omar El-Sherif, Robert Stodilka, Benoit Lewden, Michael Jerosch-Herold, Terry Thompson, Frank Prato

Improved Correction of Spatial Inhomogeneities by Surface Coils in Quantitative Analysis of First Pass Myocardial Perfusion...... 2362 Frans P.P.J. Kremers, Mark B.M. Hofman, Jan G.J. Groothuis, M Jerosch-Herold, Aernout M. Beek, Sven Zuehlsdorff, Sonia Nielles-Vallespin, Albert C. van Rossum, Rob M. Heethaar

Proton Spectroscopy Techniques to Examine Myocardial Metabolic State in Human Hearts Preserved for Transplantation ...... 2363 Matthias Peltz, Michael L. Cobert, Matthew E. Merritt, LaShondra M. West, Michael Erik Jessen

Automated-Shim Approach to Facilitate 1H-MRS in Mouse Hearts In Vivo...... 2364 Jurgen E. Schneider, Hannah Barnes, Stefan Neubauer, Peter Jezzard

Cardiac Energetics of an Anoxia-Tolerant Heart: In Vivo 31P-NMR Studies of the Freshwater Turtle Trachemys scripta ...... 2365 Jonathan A. W. Stecyk, Christian Bock, Johannes Overgaard, Tobias Wang, Anthony P. Farrell, Hans O. Pörtner

Detection of Myocardial Microvascular Disease in Latino Type-I Diabetes Mellitus Patients Using P-31 MRS...... 2366 Hee-Won Kim, Gerald M. Pohost, Padmini Varadarajan, Rohit Varma, Milena Ocon, Karam Souibri, Rafit Drori, Patrick Colletti, Adina E. Zeidler

High Resolution Cardiac 31P 2D MRS Using an Actively Decoupled Coil Setup for Metabolic Phenotyping in Mice...... 2367 Mahon L. Maguire, Hannah Barnes, Andrew Webb, Stefan Neubauer, Jurgen E. Schneider

Effect of Rapid Changes in 13C Pyruvate Concentration on Lactate and Alanine Pool Sizes and 13C Enrichment in the Heart...... 2368 Karlos X. Moreno, Scott Sabelhaus, Matthew E. Merritt, A Dean Sherry, Craig R. Malloy

Estimates of the Appropriate Pyruvate Dose for Hyperpolarized 13C Cardiac Imaging ...... 2369 Karlos X. Moreno, Scott Sabelhaus, Matthew E. Merritt, A Dean Sherry, Craig R. Malloy

Methods for Generating Propagating Shear Waves Within the Heart Using MR Elastography ...... 2370 Arunark Kolipaka, Kiaran P. McGee, Philip A. Araoz, Richard L. Ehman

Calculation of Myocardial Stiffness Using a Rapid Multiphase MRE in a Heart Simulating Phantom...... 2371 Arunark Kolipaka, Kiaran P. McGee, Philip A. Araoz, Kevin J. Glaser, Armando Manduca, Richard L. Ehman

MR Elastography as a Method for the Assessment of Myocardial Stiffness Throughout the Cardiac Cycle ...... 2372 Arunark Kolipaka, Kiaran P. McGee, Philip A. Araoz, Armando Manduca, Richard L. Ehman

Assessment of Heart Function by Cardiac MR Elastography: Comparison to Left Ventricular Pressure Measurements ...... 2373 Thomas Elgeti, Michael Laule, Nicola Kaufels, Jörg Schnorr, Uwe Hamhaber, Dieter Klatt, Sebastian Papazoglou, Carsten Warmuth, Bernd Hamm, Braun Juergen, Ingolf Sack

Cardiac Cine MRI Reveals Ischemia-Reperfused Heart Suffers a Compromise in Its Function: p21 as an Oxygen- Sensitive Regulator of Fibrosis...... 2374 Surya C. Gnyawali, Molly McCoy, Sashwati Roy, Chandan K. Sen

Restrictive Right Ventricular Physiology, Right Ventricular Fibrosis as Suggested by Cardiac Magnetic Resonance, and Exercise Capacity After Biventricular Repair of Pulmonary Atresia and Intact Ventricular Septum in Children ...... 2375 Wendy Wai Man Lam, Xue Cun Liang, Eddie Cheung, Alice KP Wu, Sophia J. Wong, Yiu Fai Cheung

Prospective Synchronization of Small Animal Cardiac MRI: A Quantitative Comparison of an Optical Device, Pressure Sensor and ECG ...... 2376 Adrian Rengle, Raphaël Sablong, Olivier Beuf

Comparison of Cardiac MR and 3D Echocardiography Left Ventricular Analysis ...... 2377 Job W.A. Gutteling, Ellemiek Wintjes, Pieter FF Wijn, Luc J.H.J. Theunissen

Comprehensive Evaluation of Diastolic Function with MRI...... 2378 Richard Thompson, June Cheng Baron, Kelvin Chow, Jessica Scott, Ben Esch, Mark Haykowsky, Ian Paterson

The Effects of Contrast Agent on Quantitative Morphological LV Parameters at 3T...... 2379 Shona Matthew, Richard Stephen Nicholas, Stephen James Gandy, Shelley Anne Waugh, Elena Crowe, Richard A. Lerski, Malcolm H. Dunn, J Graeme Houston

Determining Myocardial Function with Real-Time MRI ...... 2380 Andreas Weng, Christian Oliver Ritter, Heimo Stamm, Meinrad Joachim Beer, Dietbert Hahn, Herbert Köstler

Phased Array Imaging in Mouse Hearts Using an 8-Channel Phased Array Coil at 9.4 Tesla...... 2381 Jurgen E. Schneider, Hannah Barnes, Matthias Müller, Stefan Neubauer, Titus Lanz

Ground Truth Evaluation of One Touch Cardiac Imaging...... 2382 Robert D. Darrow, Vivek Vaidya, Rakesh Mullick, Ambey Govenkar, Vincent B. Ho, Maggie Fung, Biju Varghese, Thomas K. Foo

Whole Heart Cardiac MRI with High Temporal and Spatial Resolution Using a 128-Element Cardiac Array at 3 Tesla ...... 2383 Michael Hamm, Melanie Schmitt, Andreas Potthast, Sven Zuehlsdorff, Lawrence L. Wald, David E. Sosnovik

High Temporal and Spatial Resolution Cine MRI for Characterizing Valvular and Cardiac Alterations in a Genetic Mouse Model of Valve Disease...... 2384 Frank Kober, Stéphane Zaffran, Piotr Topilko, Patrick J. Cozzone, Monique Bernard

Sub-Minute 3D Black-Blood Imaging of the Whole Heart with Isotropic Spatial Resolution ...... 2385 Jinnan Wang, Chun Yuan, Vasily L. Yarnykh

Respiratory and Cardiac Self-Gated Free-Breathing Cardiac CINE Imaging with Multi-Echo 3D Hybrid Radial Acquisition...... 2386 Jing Liu, Pascal Spincemaille, Thanh D. Nguyen, Walter F. Block, Martin R. Prince, Yi Wang

Comparison of Self Gated Cardiac MRI with Echocardiography for Determination of Left Ventricular Function in Rodent Models of Hypertrophy ...... 2387 Kirsten Gilday, Chris McCabe, William Matthew Holmes, Mhairi Macrae, Anna Dominiczak

3D Free-Breathing Radial Cine-SSFP Using a Retrospective Z-Center-Of-Mass Self Navigator: A Feasibility Study...... 2388 Noel Christopher Codella, Pascal Spincemaille, Jing Liu, Ludovic de Rochefort, Bryan Kressler, Martin Prince, Yi Wang

Three-Dimensional Whole-Heart Cine MRI Using Prospective Self-Gating for Compensation of Cardiac and Respiratory Motion ...... 2389 Robert Manka, Martin Bührer, Peter Bösiger, Sebastian Kozerke

Predictive Modelling of Cardiac Real-Time 2D Images...... 2390 Henrik Pedersen, Henrik B.W. Larsson, Rasmus Larsen

Retrospective Triggered Free Breathing Cardiac Function with Respiratory Pencil Beam Navigators ...... 2391 Axel Bornstedt, Michael Radermacher, Vinzenz Hombach, Nico Merkle, Volker Rasche

Evaluation of Coronary Stenosis in Rat: Toward the Development of a Chronic Hibernation Model...... 2392 Karin Montet-Abou, Jean-Luc Daire, Jean-Pascal Jacob, Manuel Jorge-Costa, Denis R. Morel, Jean-Paul Vallee

Of Mice and Men: A Quantitative Comparison of 3D Cardiac Motion in Mice and Humans...... 2393 Erica Dall'Armellina, Hannah Barnes, Stefan Neubauer, Steffen E. Petersen, Michael Markl, Jurgen E. Schneider, Bernd A. Jung

Fully Automated Segmentation of Long-Axis MRI Strain-Encoded (SENC) Images Using Active Shape Model (ASM)...... 2394 Ahmed Amr Harouni, David A. Bluemke, Nael F. Osman

Analysis of True 3D Cardiac Motion Using 3D Tagged MRI ...... 2395 Yu Shimizu, Akira Amano, Tetsuya Matsuda

Volume 5

Fully Automatic 3D Cardiac Tagged MRI Analysis Using Multiple Source Non-Rigid Registration Techniques...... 2396 Maria J. Ledesma-Carbayo, Ana Bajo, John Andrew Derbyshire, Andres Santos, Manuel Desco, Elliot R. McVeigh

Strain Measurements with Displacement ENcoding with Stimulated Echoes (DENSE) Are Robust to Off Resonance...... 2397 Meral Reyhan, J A. Derbyshire, Daniel Bruce Ennis

In Vivo Comparison of CSPAMM and DENSE for Cardiac Motion Analysis ...... 2398 Christian Torben Stoeck, A Crean, J P. Greenwood, P Boesiger, S Plein, S Kozerke

Assessment of Three Dimensional Left Ventricular Strain After VEGF Gene Therapy in Occlusive Infarction on Magnetic Resonance Imaging ...... 2399 Maythem Saeed, Marcus Carlsson, Demetrius Dicks, Alastair Martin, David Saloner

Balanced Multi-Point Displacement Encoding for DENSE MRI: Theoretical and Experimental Results...... 2400 Xiaodong Zhong, Patrick Helm, Frederick H. Epstein

Multiparametric T1 Weighted Imaging May Identify Carotid Plaque Components ...... 2401 G. Leung, Rahul Sarkar, James Q. Zhan, Alan R. Moody

Assessment of Fibrous Cap Status of Carotid Artery Plaques by Contrast-Enhanced MRI ...... 2402 Robert Kwee, Werner Mess, Robert van Oostenbrugge, Cees Franke, Floris Schreuder, Arthur Korten, Be Meems, Joachim Wildberger, Jos van Engelshoven, Eline Kooi

High-Resolution 3T Carotid MRI Identifies the High-Risk Lesion in Patients with Moderate (<70%) Carotid Stenosis...... 2403 J. Kevin DeMarco, Hideki Ota, Hunter R. Underhill, David Zhu, Mat Reeves, Arshad Majid, Alonso Collar, Minako Oikawa, Li Dong, Xihai Zhao, Feiyu Li, Vasily L. Yarnykh, Chun Yuan

Comparative Evaluations of 3D Turbo Spin Echo (TSE) Motion Sensitized Driven Equilibrium (MSDE) and 2D Double Inversion Recovery TSE Sequences for T1-Weighted Black-Blood Carotid Atherosclerosis Imaging...... 2404 Daisuke Ito, Minako Oikawa, Hideki Ota, Makoto Obara, Akira Suwa, Isao Yanagisawa, Shoki Takahashi, Hiroaki Shimokawa

Whole Body Three Dimensional Plaque Imaging ...... 2405 Yiu-Cho Chung, Georgeta Mihai, Orlando P. Simonetti, Sanjay Rajagopalan, Renate Jerecic

Accelerated 3D Carotid Vessel Wall Imaging Using Compressed Sensing...... 2406 Mahender K. Makhijani, Krishna S. Nayak

Effect of Cardiac Gating in High-Resolution MRI of the Carotid Vessel Wall...... 2407 Rahul Sarkar, Alan R. Moody, General Leung

Carotid Plaque Assessment Using Fast 3D Isotropic-Resolution Black-Blood MRI ...... 2408 Niranjan Balu, Vasily Yarnykh, Baocheng Chu, Jinnan Wang, Thomas Hatsukami, Chun Yuan

High Resolution Carotid Plaque MRI Using a Custom Gradient Coil Insert ...... 2409 Jordan P. Hulet, Seong-Eun Kim, John A. Roberts, Daniel R. Nightingale, Gerald S. Treiman, Dennis L. Parker

3D SPACE Arterial Wall Imaging with Prospective Self-Gating for Motion Compensation...... 2410 Zhaoyang Fan, Sven Zuehlsdorff, Peng Lai, Peter Weale, Yiucho Chung, Debiao Li

The Potential Problems Associated with Carotid Motion in Carotid Artery Imaging...... 2411 Cheuk Fan Chan, Peter Gatehouse, Dudley John Pennell, David Firmin

Halting the Effects of Flow Enhancement with Effective Intermittent Zeugmatographic Encoding (HEFEWEIZEN) in SSFP ...... 2412 Jamal Jon Derakhshan, Mark A. Griswold, Jeffrey L. Sunshine, Jeffrey L. Duerk

Imaging of Carotid Artery Plaques: Correlation Between 18F-FDG-PET and MRI Findings ...... 2413 Robert Kwee, Robert van Oostenbrugge, Werner Mess, Rob van der Geest, Cees Franke, Hans ter Berg, Arthur Korten, Be Meems, Gerrit Teule, Jos van Engelshoven, Joachim Wildberger, Eline Kooi

Non-Contrast-Enhanced MR Identification of Deep Vein Thrombosis: A Feasibility Study...... 2414 Houman Mahallati, Michel Louis Lauzon, Linda Andersen, Richard Frayne

Quantification of Calcifications in Endarterectomy Samples by Means of High-Resolution Ultra-Short TE Imaging...... 2415 Sonu Sharma, Axel Bornstedt, Said Boujraf, Volker Rasche

Dual Echo Dynamic MRI Using Dy- Micelles and Gd-DTPA as a Contrast Agent...... 2416 Venkatesh Mani, Claudia Calcagno, Karen C. Briley-Saebo, Zahi A. Fayad

Plaque Progression in the ApoE-/- Mouse Model of Atherosclerosis Monitored in Three Vascular Beds ...... 2417 Basil Künnecke, Sabine Grüner, Jürgen Fingerle, Markus von Kienlin

Delayed Enhancement MRI of an in Vivo Model of Atherosclerotic Plaque Using a Blood-Pool Contrast Agent...... 2418 Stephanie Elaine-GarWai Chiu, Alan R. Moody, James Q. Zhan, General Leung

Comparison of USPIO-Enhanced MRI and Magnetically Labelled Cell Tracking for Inflammation Detection in ApoE Mice ...... 2419 Olivia Monica Sigovan, Amine Bessaad, Hassan Alsaid, Genevieve De Souza, Claire Corot, Nicolas Provost, Zouher Majd, Christine Menager, Norbert Nighoghossian, Serge Nataf, Emmanuelle CanetSoulas

Pharmacological Inhibition of CCR2 Decreases Macrophage Infiltration in the Aortic Root of the HuCCR2ki / ApoE-/- Mouse: MRI Assessment...... 2420 Gregory H. Turner, Alan R. Olzinski, Roberta E. Bernard, Heather Karr, Carla A. Cornejo, Karpagam Aravindhan, Bao Hoang, Robert N. Willette, Colin H. MacPhee, Clark A. Sehon, Peter J. Gough, Beat M. Jucker

Detection of Atherosclerotic Plaques in the Aortic Arch Using Lipid-Based Contrast Agents ...... 2421 Brigit den Adel, Linda M. van der Graaf, Bianca Hogers, Glenda S. van Bochove, Marco C. Deruiter, Klaas Nicolay, Louise van der Weerd, Robert E. Poelmann

Atherosclerotic Plaques MRI Detection in ApoE -/- Mice Using the Blood Pool Agent B22956/1...... 2422 Claudia Cabella, Giulia Chiesa, Vito Lorusso, Alessandro Maiocchi, Marta Marchesi, Luigi Miragoli, Cinzia Parolini, Luisa Poggi, Fabio Tedoldi, Fulvio Uggeri, Giovanni Valbusa

Comparison of Segmented and Single-Shot DENSE MRI of the Carotid Arteries at 3T ...... 2423 Alexander Peter Lin, Scott Fraser, Han Wen

3.0 Tesla MRI Common Carotid Wall Shear Stress Measurements: Correlations with Common Carotid Arterial Wall Thickness...... 2424 Raphael Duivenvoorden, Eric de Groot, Ed van Bavel, Ramsi Amri, Erik Stroes, J. Lameris, J. Kastelein, Aart J. Nederveen

Mechanical Stress Levels in Symptomatic Patients Scheduled for Carotid Endarterectomy ...... 2425 Samuel Alberg Kock, Jens Vinge Nygaard, Anders Niemann, Anette Klærke, Nikolaj Eldrup, Søren Dalager, William Paaske, Won Yong Kim

Local –not Global- Maximal Structural Stress Associates with Vulnerable Plaque Features...... 2426 Gador Canton, Li Dong, Hunter R. Underhill, William S. Kerwin, Zhongzhao Teng, Dalin Tang, Baocheng Chu, Thomas S. Hatsukami, Chun Yuan

Circumferential Cyclic Strain in the Abdominal Aorta: Comparison of a Phase-Contrast Magnetic Resonance Imaging Vs. a FIESTA Method ...... 2427 Janice J. Yeung, Andrea S. Les, Jinha M. Park, Robert J. Herfkens, Ronald L. Dalman, Charles A. Taylor

Imaging High-Speed Jets Using Rapid Ungated Fourier Velocity Encoding ...... 2428 Hattie Zhi Chen Dong, Bob S. Hu, Juan M. Santos, Dwight G. Nishimura

Aortic Stiffness Is Related to Left Ventricular Diastolic Dysfunction in Heart Failure with Normal Ejection Fraction as Measured by MRI ...... 2429 ElSayed H. Ibrahim, Alan Miller, Richard D. White

Estimation of Local Aortic Pulse Wave Velocity in a Single Heartbeat...... 2430 Michael C. Langham, Jeremy Magland, Felix W. Wehrli

Different Techniques for Measuring Aortic Pulse Wave Velocity Using Magnetic Resonance Imaging ...... 2431 ElSayed H. Ibrahim, Kevin R. Johnson, Richard D. White

Regional Transit Time Measurement of Pulse Wave Velocity in the Murine Aorta ...... 2432 Marco Parczyk, Volker Herold, Gert Klug, Peter Michael Jakob, Wolfgang Rudolf Bauer, Eberhard Rommel

Deformation, Strain, and Pressure-Strain Elastic Modulus at the Supraceliac, Infrarenal, and Mid-Aneurysm Levels in the Aneurysmal Abdominal Aorta ...... 2433 Andrea Seba Les, Janice J. Yeung, Geoffrey M. Schultz, Robert J. Herfkens, Ronald L. Dalman, Charles A. Taylor

Mean Pulmonary Arterial Pressure Estimation by High Temporal Resolution Phase-Contrast MR Imaging in Patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Correlation with Simultaneous Invasive Pressure Recordings – First Results...... 2434 Stefan Weber, Gesine Maria Wirth, R Peter Kunz, Michael B. Pitton, E Mayer, Chistoph Düber, Karl Friedrich Kreitner

Time-Resolved Blood Flow Quantification with Ungated Radial Sampling...... 2435 Michael C. Langham, Jeremy Magland, Felix W. Wehrli

Flow Quantification in the Heart Chambers: 3D PC-SSFP Compared with Spoiled GE...... 2436 Marijn P. Rolf, Mark B.M. Hofman, Joost P.A. Kuijer, Albert C. van Rossum, Rob M. Heethaar

Undersampled Spirals for Real-Time Flow Measurements...... 2437 Jennifer Edgar, Vivek Muthurangu, Andrew Taylor, David Atkinson

Investigating the Potential of MRI as a New Non-Invasive Modality for Wave Intensity Analysis (WIA) in Healthy and Renal Disease Subjects ...... 2438 Celine Quinsac, Alan Jackson, Philip Kalra, Helen Eddington, Paul Dark

Robust Estimation of Changes in Transverse Relaxation from Magnitude MRI Data: Application to Vessel Size Imaging ...... 2439 Simon Walker-Samuel, Matthew Orton, Lesley D. McPhail, Simon P. Robinson

MRI Turbulence Quantification...... 2440 Petter Dyverfeldt, Roland Gårdhagen, Andreas Sigfridsson, Matts Karlsson, Tino Ebbers

In Vivo Measurement of Regional and Local Pulse-Wave Velocity in Mice with MRI at 17.6 T ...... 2441 Volker Herold, Marco Parczyk, Gert Klug, Wolfgang Rudolf Bauer, Peter Michael Jakob, Eberhard Rommel

Simultaneous Angiography and Venography Techniques Compared at 7T ...... 2442 Samuel Barnes, Yulin Ge, Lin Tang, Zhongwei Zhang, Daniel K. Sodickson, Robert I. Grossman, E. Mark Haacke

Single Echo Simultaneous Angiography and Venography (MRAV) Techniques at 3T ...... 2443 Samuel Barnes, E. Mark Haacke

Compatible Dual-Echo Arteriovenography (CODEA) Using an Echo-Specific Kspace Reordering Scheme...... 2444 Sung-Hong Park, Chan-Hong Moon, Kyongtae Ty Bae

Effective Application of Multiple Overlapping Thin-Slab Acquisition and Magnetization Transfer Contrast Pulse to Compatible Dual-Echo Arteriovenography (CODEA)...... 2445 Sung-Hong Park, Chan-Hong Moon, Kyongtae Ty Bae

Compatible Dual-Echo Arteriovenography (CODEA) Imaging at 7T Versus 3T ...... 2446 Kyongtae Ty Bae, Sung-Hong Park, Chan-Hong Moon, Jung-Hwan Kim

View Sharing in Slice Direction for Continuously Moving Table Acquisitions: Application to TOF Venography...... 2447 Sandra Huff, Matthias Honal, Michael Markl, Ute Ludwig

Acute Renal Effect Following 0.1 Mmol/kg OMNISCAN„ (Gadodiamide Injection) Administration for Magnetic Resonance Angiography (MRA) of the Renal Arteries...... 2448 Vesna D. Garovic, Manuela Aschauer, Thomas Kittner

Pre-Operative Localization of the Artery of Adamkiewicz Using Time-Resolved Magnetic Resonance Angiography at 3.0T ...... 2449 Cory Christopher Duffek, Thorsten A. Bley, Christopher J. Francois, Mark L. Schiebler, Matthew Mell, Thomas Grist, Scott B. Reeder

Gadofosveset Trisodium-Enhanced Steady State Free Precession Magnetic Resonance Angiography of Left Atrium and Pulmonary Veins ...... 2450 Moritz Wagner, Patrick Asbach, Alexander Huppertz, Matthias Taupitz, Carsten Warmuth, Bernd Hamm, Alexander Lembcke

On the Amenability of Ghost Imaging to Large Parallel Acceleration Factors ...... 2451 Ioannis Koktzoglou, Robert R. Edelman 0 Inflow-Sensitive Inversion Recovery SSFP Imaging of the Carotid Arteries: A Potential Strategy for Noncontrast MRA of the Neck ...... 2452 Phillip Young, Mohammad-Mehdi Khalighi, Anja Brau, Naoyuki Takei, Wei Sun, Robert Herfkens

Comparison of Non-Contrast In-Flow Inversion Recovery (Inhance) Steady State Free Precession Renal MRA at 1.5T and 3T ...... 2453 David W. Stanley, James F. Glockner, Naoki Takahashi, Steven L. Williams, Marilyn R. Wood, Naoyuki Takei, Sun Wei

Analysis of Renal Artery Motion During Free Breathing...... 2454 Ashley Gould Anderson III, Kevin M. Johnson, Oliver Wieben

Non-Contrast MR Angiography of the Renal Arteries: Improvements in Vessel Length and SNR with Multiple Heartbeat Inflow Period ...... 2455 Steven M. Shea, Seth J. Berkowitz, Jens Vogel-Claussen, Aravind Arepally, Peter Weale, Xiaoming Bi, Christine H. Lorenz, David A. Bluemke

Unenhanced 3D Ghost MR Angiography by Toggled Systolic and Diastolic Imaging...... 2456 Ioannis Koktzoglou, Robert R. Edelman

Non-Contrast Enhanced Renal Angiography Using Multiple Inversion Recovery and Steady-State Free Precession...... 2457 Hattie Zhi Chen Dong, Holden H. Wu, Dwight G. Nishimura

The Mathematics of HYPR ...... 2458 Angel Ramon Pineda, Atousa Sarcon, Nasser Abbasi, Doug Stang, Siavash Jalal, Kacie Jacklin, Reed F. Busse, Jean H. Brittain

Refocused Turbo Spin Echo for Noncontrast MRA...... 2459 Samuel W. Fielden, John P. Mugler III, Klaus D. Hagspiel, Christopher M. Kramer, Craig H. Meyer

NATIVE SPACE Angiography with MTC and Fat Saturation Pulses ...... 2460 Agus Priatna, Glenn Foster, Jian Xu, Peter Weale, Scott Love, Vamsi Narra

Continuously Moving Table Time-Of-Flight Angiography of the Peripheral Veins ...... 2461 Sandra Huff, Matthias Honal, Tobias Baumann, Jürgen Hennig, Michael Markl, Ute Ludwig

Non-Contrast Abdominal Angiography Using Continuous Arterial Spin Labeling and Background Suppression...... 2462 Philip M. Robson, Weiying Dai, Ajit Shankaranarayanan, David C. Alsop

Non-Contrast-Enhanced MRA of the Renal Arteries Using Inflow-Enhanced, Inversion-Recovery BSSFP: Validation Against DSA in a Porcine Model of Renal Artery Stenosis ...... 2463 Thorsten Alexander Bley, Christopher Jean Pierre Francois, Mark L. Schiebler, Oliver Wieben, Naoyuki Takei, Wei Sun, Mitsuharu Miyoshi, Jean H. Brittain, Reed F. Busse, Thomas M. Grist, Scott B. Reeder

Flow-Independent, Non-Contrast-Enhanced, Free Breathing Renal MR Angiography...... 2464 Gregory J. Wilson, George R. Oliveira, Jeffrey H. Maki

Fat Suppression for Non-Contrast-Enhanced Peripheral Angiography: Phase-Sensitive Versus IDEAL SSFP...... 2465 Tolga Çukur, Ann Shimakawa, Huanzhou Yu, Brian A. Hargreaves, Bob S. Hu, Jean H. Brittain, Dwight G. Nishimura

Non-Contrast Enhanced MRA Using Inhance Inflow IR with 3D FRFSE for Carotid Artery Imaging ...... 2466 Naoyuki Takei, Mitsuharu Miyoshi, Tetsuji Tsukamoto

Impact of Timing and Dose of Isosorbide Dinitrate Administration on Coronary MRI ...... 2467 Peng Hu, Dana C. Peters, Kraig V. Kissinger, Beth Goddu, Lois Goepfert, Warren J. Manning, Reza Nezafat

Feasibility of Whole-Heart Coronary MRA on 3 Tesla Using Ultrashort-TR SSFP VIPR ...... 2468 Jingsi Xie, Peng Lai, Himanshu Bhat, Debiao Li

Coronary Artery Imaging at 3T: A 32- Versus 6-Channel Cardiac Coil Comparison ...... 2469 Andrea J. Wiethoff, John J. Totman, Sergio A. Uribe Arancibia, Tobias Schaeffter, Rene M. Botnar

Coronary MR Angiography in Children During Systole and Diastole Using a Dual Cardiac Phase Scan of the Whole Heart ...... 2470 Sergio Andres Uribe Arancibia, Israel Valverde, Philipp Beerbaum, Aaron Bell, Rene Botnar, Reza Razavi, Tobias Schaeffter, Gerald Greil

Contrast-Enhanced Whole-Heart Coronary MRA at 3T Using Gradient Echo Interleaved EPI and Single Dose of Gd-BOPTA...... 2471 Himanshu Bhat, Sven Zuehlsdorff, Renate Jerecic, Debiao Li

ContinuousLy Adaptive Windowing Strategy (CLAWS): An Automatic Technique for Achieving the Best Possible Respiratory Efficiency Regardless of the Breathing Pattern...... 2472 Permi Jhooti, Jennifer Keegan, David Firmin

Model-Free Slice Following Using the Cardiac Fat Navigator: Enhanced Gating Efficiency for 3D SSFP Coronary Magnetic Resonance Angiography ...... 2473 Pascal Spincemaille, Thanh Dang Nguyen, Martin Prince, Yi Wang

Feasibility Study of Automatic Breathing Level Tracking and Active Breathing Level Control Methods for Whole- Heart Magnetic Resonance Coronary Angiography (WH MRCA)...... 2474 Shigehide Kuhara, Satoru Hasebe, Seiko Mizuno, Masatoshi Hyodo, Takahiro Yamamoto, Sachiko Ueoku, Ayako Ninomiya, Hirofumi Anno

On-Resonant Binomial Pulse Preparation for Magnetization Transfer Contrast Enhanced Coronary Vein Imaging ...... 2475 Christian Torben Stoeck, Dana C. Peters, Yuchi Han, Kraig V. Kissinger, Beth Goddu, Lois Goepfert, Warren J. Manning, Sebastian Kozerke, Reza Nezafat

Impact of Preparation Phases on Vessel Wall Imaging Using Spiral Image Acquisition at 3 Tesla...... 2476 Miriam Wilhelmina Lagemaat, Markus Henningsson, Peter Boernert, Jouke Smink, Andrea J. Wiethoff, Rene M. Botnar

Robust and Time-Efficient Black Blood Coronary Vessel Wall Imaging at 3T Using IMSDE...... 2477 Jinnan Wang, Suzanne Gerretsen, Jeffrey H. Maki, Daniel Herzka, Baocheng Chu, Vasily L. Yarnykh, Chun Yuan, Tim Leiner

Coronary Vessel Wall Thickness: Validation of MR Coronary Vessel Wall Imaging with Intravascular Ultrasonography...... 2478 Suzanne C. Gerretsen, M. Eline Kooi, Rene M. Botnar, Johannes Waltenberger, Rob J. van der Geest, J. Dijkstra, J. H. Reiber, Tim Leiner

Coronary Vessel Wall Imaging Using Reduced Field of View Double Inversion Recovery Fast Spin Echo ...... 2479 Hao Shen, Guang Cao, Qian Zhao, Liuquan Cheng, Chun Yuan

Navigator-Gated Whole Heart Coronary MRI with 3D Isotropic Double Echo TrueFISP UTE...... 2480 Sonia Nielles-Vallespin, Peter Speier, Peter Weale, Saurabh Shah, Edgar Mueller

Analysis of Endocardial Border Sharpness of Accelerated 2D CINE SSFP: Implications for Left Ventricular Function Assessment ...... 2481 Fabian Hezel, Marcus Katoh, Harald Kühl, Helena Grawe, Jane F. Utting, Thoralf Niendorf

Rapid and Accurate Quantification of Left Ventricular Ejection Fraction Using an Automated Segmentation Algorithm – a Clinical Validation Study...... 2482 Noel Christopher Codella, Matthew D. Cham, Richard Wong, Christopher W. Chu, Keigo Kawaji, Kirsten Healey, Martin R. Prince, Yi Wang, Jonathan W. Weinsaft

The KLT Filter as a Method of "Smart Averaging" to Improve SNR in Real-Time Cine MRI...... 2483 Yu Ding, Yiu-cho Chung, Orlando P. Simonetti

Morphological Studies of the Murine Heart Based on Probabilistic and Statistical Atlases...... 2484 Dimitrios Perperidis, Elizabeth Bucholz, G Allan Johnson, Christakis Constantinides

Unsupervised Fully Automated Inline Analysis of Global Left Ventricular Function in MR Imaging ...... 2485 Daniel Theisen, Torleif Sandner, Kerstin Bauner, Carmel Hayes, Maximilian F. Reiser, Bernd J. Wintersperger

3.0 Tesla MRI Common Carotid Wall Shear Stress Quantification: Poiseuille Estimation Versus Non-Linear Fitting of Velocity Data...... 2486 Raphael Duivenvoorden, Eric de Groot, Ed van Bavel, Ramsi Amri, Erik Stroes, J. Lameris, J. Kastelein, Aart J. Nederveen

Platform for Comprehensive Hemodynamic Analysis of 4D PC MRI Data...... 2487 Elizabeth Janus Nett, Kevin M. Johnson, Benjamin R. Landgraf, Oliver Wieben

A Nonparametric Method for Intensity Non-Uniformity Correction in Carotid MR Images ...... 2488 Wenbo Liu, Guangzhi Wang, Hui Ding

Time-Of-Arrival Mapping for 3D Time-Resolved Contrast-Enhanced MRA ...... 2489 Stephen J. Riederer, Clifton R. Haider, Eric A. Borisch

Localized Measurement of Atherosclerotic Plaque Inflammatory Burden with Dynamic Contrast-Enhanced MRI...... 2490 Huijun Chen, Jianming Cai, Xihai Zhao, Thomas S. Hatsukami, Chun Yuan, William S. Kerwin

P31 NMR Demonstrates Dysfunction Through Mitochondrial Uncoupling in Skeletal Muscle After Burn Injury...... 2491 Dionyssios Mintzopoulos, Meenu Kesawarni, Laurence G. Rahme, Ronald G. Tompkins, A Aria Tzika

Influence of Foot Orientation on the Appearance of 1H Muscle Spectra Obtained from Soleus and Vastus Lateralis...... 2492 Malgorzata Marjanska, Lisa Chow, Gregor Adriany, Elizabeth R. Seaquist, Michael Garwood

31CSI and MRS at 7T Detect an Alkaline PH Compartment in Resting Human Soleus Muscle...... 2493 Hermien E. Kan, Dennis W.J. Klomp, Andrew G. Webb, Peter R. Luijten, Jeroen A.L. Jeneson

Slow Decay of Acetyl-Carnitine in Skeletal Muscle After Exercise ...... 2494 Jimin Ren, Ivan Dimitrov, Dean Sherry, Craig Malloy

Differences in Skeletal Muscle Lipid Metabolism in Upper and Lower Extremities by Localized Correlated Spectroscopy...... 2495 Steven L. Lindauer, John Austin Vargo, Steven Coon, Raymond R. Raylman, M. Albert Thomas, Richard G. Spencer, Stephen E. Alway, S. Sendhil Velan

31P NMR Demonstrates Reduced ATP Synthesis Rate and Concomitant Downregulation of PGC-1β Mitochondrial Gene Expression in Skeletal Muscle After Burn Injury...... 2496 Dionyssios Mintzopoulos, Michael N. Mindrinos, Laurence G. Rahme, Ronald G. Tompkins, A Aria Tzika

T1 and T2 Relaxation Time Measurements of Metabolites in Human Calf Muscle at 7 Tesla ...... 2497 Jimin Ren, Ivan Dimitrov, A. Dean Sherry, Craig R. Malloy

Progression of Fat Infiltration in Calf, Thigh and Pelvic Muscles in Duchenne Muscular Dystrophy: Quantification by MRI Over an 18 Month Period ...... 2498 Kieren Grant Hollingsworth, Penelope Garrood, Benjamin Segun Aribisala, Daniel Birchall, Michelle Eagle, Kate Bushby, Volker Straub

Quantitative MRI Analysis of Two Icing Techniques in Skeletal Muscle Injury in a Rat Hind Limb Model...... 2499 Thomas Neuberger, Andrew Webb, Eric Fontaine, Nicole McBrier

Compartmental Relaxation Measurements in a Graded Muscle Edema Model...... 2500 Jack Thomas Skinner, Mark D. Does

Perfusion Imaging of Free Flaps with Contrast Harmonic Ultrasound Imaging, Laser-Induced Indocyanine Green Fluorescence Angiography and Magnetic Resonance Imaging...... 2501 Ernst M. Jung, Lukas Prantl, Andreas G. Schreyer, Niels Zorger, Stefan Feuerbach, Claudia Fellner

Perfusion Measurements During Reactive Hyperemia in Human Soleus Muscle ...... 2502 Markus Klarhöfer, Claudia Lenz, Tanja Haas, Klaus Scheffler, Rolf Pohmann

Line Scan Diffusion Spectrum of the Denervated Skeletal Muscle for Early Diagnosis of Peripheral Nerve Injuries: An Experimental Study...... 2503 Eiko Yamabe, Toshiyasu Nakamura, Yukihiko Obara, Koji Abe

Evaluation of Skeletal Muscles After Strenuous Exercise with Magnetic Resonance Imaging and Ultrasonography...... 2504 Osamu Yanagisawa, Toshiyuki Kurihara, Koji Okumura, Toru Fukubayashi

Independent Effect of Extravascular BOLD Effects on Muscle Relaxation Parameters...... 2505 Otto Alexander Sanchez, Elizabeth Anne Copenhaver, Marti Ann Chance, Bruce Murray Damon

Similarity Between Deoxyhemoglobin Concentration and R2’ Time Course During Isometric Dorsiflexion...... 2506 Christopher Paul Elder, Marti Ann Chance, Ryan N. Cook, Bruce M. Damon

Accuracy and Precision of MR Blood Oximetry Based on the Long Paramagnetic Cylinder Approximation of Large Vessels...... 2507 Michael C. Langham, Jeremy Magland, Charles L. Epstein, Thomas F. Floyd, Felix W. Wehrli

SNR Requirements for Accurate Estimation of Magnitude and Kinetic Properties of Post-Contraction Signal Transients ...... 2508 Elizabeth A. Copenhaver, Otto A. Sanchez, Bruce M. Damon

Diffusion Tensor Imaging of the Human Calf – Distinct Changes in Fractional Anisotropy and Mean Diffusion Due to Muscle Shortening and Stretching ...... 2509 Nina F. Schwenzer, Günter Steidle, Petros Martirosian, Christina Schraml, Fabian Springer, Claus D. Claussen, Fritz Schick

Mapping Cross-Sectional Skeletal Muscle Asymmetry Via High Angular Resolution Diffusion Imaging...... 2510 Dimitrios C. Karampinos, Kevin F. King, Danchin Chen, Bradley P. Sutton, John G. Georgiadis

Muscle Fiber Tracking and Segmentation in the Human Forearm...... 2511 Martijn Froeling, Jos Oudeman, Sandra van den Berg, Anna Vilanova, Klaas Nicolay, Mario Maas, Gustav Strijkers, Aart Nederveen, Maarten Drost

Diffusion Tensor Magnetic Resonance Imaging (DTI) of Abnormalities in the Thigh Muscles of Polymyositis Patients...... 2512 Jane H. Park, Brittany C. Lee, Jing Qi

Dynamic DTI During Muscle Contraction by Electrical Stimulation...... 2513 Yasuharu Watanabe, Keisaku Kimura, Masahiro Umeda, Toshihiro Higuchi, Chuzo Tanaka

Improved Estimation of Muscle Water Diffusion Properties Using Dixon Imaging ...... 2514 Bruce M. Damon, Jane H. Park, J. Herman Kan

MRI Assessment of Passive Muscular Mechanics in Vivo Using Intensity Based Nonrigid B-Spline Registration: Effects of Epimuscular Myofascial Force Transmission...... 2515 Alper Yaman, Maria J. Ledesma-Carbayo, Guus C. Baan, Peter A. Huijing, Can A. Yucesoy, Cengizhan Ozturk

Accuracy and Precision Analysis of a Semi-Automated Spatial Tag Position Detection Method...... 2516 Erin Kristine Englund, Bruce M. Damon

Advanced Exercise Ergometer Setup for in Vivo MRS Studies of Skeletal Muscle Metabolism...... 2517 Susanne Heinzer-Schweizer, Flurin Item, Anke Henning, Marco Toigo, Peter Boesiger

Quantitative Assessment of Trabecular Bone Structure in the Presence of Bone Marrow Edema-Like Lesions (BMEL): IDEAL Versus FIESTA-C...... 2518 Radu Ioan Bolbos, Daniel Kuo, Ann Shimakawa, Huanzhou Yu, Michael Ries, Sharmila Majumdar, Xiaojuan Li

Quantitative Measurement of Bone Marrow Composition and Bone Structure Using Simultaneous Acquisition of Fat Fraction and T2 with Multiple Gradient Echo Images ...... 2519 Eito Kozawa, Tomoyuki Okuaki, Waka Saito, Kaiji Inoue, Yasuo Sakurai, Fumiko Kimura

Simultaneous Estimation of T2, T2-Dagger and Lipid Content in Bone with a Novel Iterative Algorithm ...... 2520 Christian Graff, Kenneth L. Weiss, Eric W. Clarkson, Maria I. Altbach

Reproducibility of Trabeculae Bone Structural Parameters at Two Resolution Regimes...... 2521 Michael J. Wald, Jeremy F. Magland, Yusuf Bhagat, Hee Kwon Song, Felix W. Wehrli

Evaluation of Motion Corruption on Image Quality in Micro MRI of Trabecular Bone: Impact on Structural Parameters ...... 2522 Yusuf A. Bhagat, Michael J. Wald, Chamith S. Rajapakse, Hamid Saligheh Rad, Jeremy F. Magland, Mary B. Leonard, Felix W. Wehrli

Is Bone Marrow Diffusion Too Slow or Too Fast for Susceptibility-Based Methods to Assess Trabecular Bone Architecture? ...... 2523 Henry H. Ong, Alexander C. Wright, Suzanne L. Wehrli, Catherine E. Jones, Felix W. Wehrli

Relaxometric Characterization of Human Cortical Bone...... 2524 Robert Adam Horch, Richard Darrell Dortch, Jeffrey S. Nyman, Daniel Frank Gochberg, Mark. D. Does

Non-Gaussian Diffusion to Investigate Bone Marrow...... 2525 Silvia De Santis, Silvia Capuani

High Resolution Imaging of Trabecular Bone Structure Using Wideband SSFP ...... 2526 Suchandrima Banerjee, Ajit Shankaranarayanan, Hsu-Lei Lee, Krishna S. Nayak, Sharmila Majumdar, Eric T. Han

Spectrally-Selective IR Diffusion-Weighted Imaging with SSFP of Bone Marrow at 3T ...... 2527 Yousef Mazaheri, Jan Grimm, Ersin Bayram, David M. Panicek, Jason A. Koutcher, Hedvig Hricak

Measurements of Inter- And Intravoxel Dephasing of Trabecular Bone at 7T Field Strength Using a Chemical Shift-Selective Asymmetric Spin-Echo (Chase) Sequence ...... 2528 Roland Krug, Andrew J. Burghardt, Kathryn E. Hammond, Suchandrima Banerjee, Douglas A.C. Kelley, Ahi S. Issever, Thomas M. Link, Sharmila Majumdar

Measuring Composition of Bone Marrow by Partial Water and Fat Suppression Proton Projection MRI (WASPI) for Correction of X-Ray Measurement of Bone Mineral Density...... 2529 Haihui Cao, Jerome Ackerman, Melvin Glimcher, Yaotang Wu

Low-SAR Trabecular Bone Micro-MRI for Use at Ultra-High Field ...... 2530 Jeremy F. Magland, Alex C. Wright, Hamidreza Saligheh-Rad, Felix W. Wehrli

Efficient Mechanical Bone Parameter Estimation on the Basis of Grayscale Magnetic Resonance Images ...... 2531 Jeremy F. Magland, Chamith Rajapakse, X H. Zhang, X E. Guo, Felix W. Wehrli

3D Rigid Registration of MRI and HR-PQCT Trabecular Bone Images ...... 2532 Janet Blumenfeld, Jenny Folkesson, Galateia Kazakia, Thomas M. Link, Sharmila Majumdar

Correction of Coil Induced Intensity Inhomogeneities in Magnetic Resonance for Trabecular Bone Analysis ...... 2533 Jenny Folkesson, Roland Krug, Ahi S. Issever, Charles Fang, Thomas Link, Sharmila Majumdar

Localized Correlated Spectroscopy of Bone Marrow: Determination of Unsaturation and Apoptosis ...... 2534 S. Sendhil Velan, Steven L. Lindauer, John Austin Vargo, Steven Coon, Raymond R. Raylman, Ravinder R. Regatte, Vazhaikkurichi M. Rajendran, Richard G. Spencer

Tissue-Engineered VEGF-Impregnated Construct to Enhance Angiogenesis for Improved Bone Regeneration: An In-Vivo Longitudinal DCE-MRI Study ...... 2535 Marine Beaumont, Marc G. DuVal, Walid A. Farhat, George K. B Sàndor, Hai-Ling Margaret Cheng

Age Dependence of Signal Intensity Ratio of In-Phase and Opposed Phase Image in Normal Spinal Bone ...... 2536 Eito Kozawa, Naoko Nishi, Youichi Sato, Shinichi Watanabe, Junji Tanaka

Congenital Malformations of Occipital Vertebrae as Cause of Instability and Degeneration of Atlanto-Axial Joints...... 2537 Carolina Medeiros Rimkus, Verônica Araújo Zanardi, Alberto Cliquet Jr

MRI and PET/CT of Patients with Bone Metastases from Breast Carcinoma ...... 2538 Johan Grankvist, Rune V. Fisker, Victor Vishwanath Iyer, Finn Taagehøj Jensen, Ernst-Torben Fründ, Carsten Wiberg Simonsen, Thorkil Christensen, Lars Stenbygaard, Marianne Ewertz Kvistgaard, Elna-Marie Larsson

Early Bone Marrow Conversion in Adolescents with Anorexia Nervosa: A T1 Relaxometry Study...... 2539 Sridhar Vajapeyam, Henry Feldman, Kirsten Ecklund, Catherine Buzney, Paul K. Kleinman, Robert Vincent Mulkern, Catherine Gordon

T1p Mapping of Pediatric Epiphyseal and Articular Cartilage...... 2540 Jared Guthrie Cobb, J. Herman Kan

Correlation Between T1p MRI and Arthroscopy in Adults with Chondromalacia...... 2541 Walter RT Witschey, Ari Borthakur, Matt Fenty, J. Bruce Kneeland, Jess Lonner, Erin Leigh McArdle, Ravinder Reddy

Assessment of Cartilage T1rho Values in Osteoarthritic Patients with and Without Meniscal Tears at 3T...... 2542 Ligong Wang, Mark E. Schweitzer, Ravinder R. Regatte

Feasibility and Reproducibility of T1p MRI Examining Osteoarthritis in a Guinea Pig Model ...... 2543 Matthew Fenty, Erin McArdle, Victor Kassey, Walter RT Witschey II, Arijitt Borthakur, Ravinder Reddy

Intra- And Inter-Scanner Variability of Knee Cartilage T2 in Human Knees at 3.0T: A Multivendor Comparision Study ...... 2544 Sharon Balamoody, Charles Edward Hutchinson, John C. Waterton, Tomos G. Williams, Michael Bowes, Richard Hodgson

Practical T2 Mapping of Cartilage in a Rabbit Model of Hemophilic Arthropathy ...... 2545 Afsaneh Amirabadi, Elka Miller, Logi Vidarsson, Marshall S. Sussman, Hai-Ling Margaret Cheng, Andrea S. Doria

Bi-Exponential T2 Mapping of the Knee Cartilage: Results on Explants...... 2546 Yongxian Qian, Ashley A. Williams, Constance R. Chu, Fernando E. Boada

Depth-Wise Modulation of T2 Relaxation Time in Articular Cartilage Degeneration ...... 2547 Mikko Johannes Nissi, Petro Kalle Julkunen, Miika Tapio Nieminen, Jukka Sakari Jurvelin

The Influence of Chemical Shift Artifacts on Cartilage T2 Mapping ...... 2548 Toshiyuki Shiomi, Takashi Nishii, Hisashi Tanaka, Mina Okamoto, Hideki Yoshikawa, Nobuhiko Sugano

The Relationship Between the Spatial Distribution of Cartilage MR T2 and Longitudinal Changes in Pain: Data from the Osteoarthritis Initiative...... 2549 Gabrielle Blumenkrantz, Julio Carballido-Gamio, Charles E. McCulloch, John A. Lynch, Thomas M. Link, Sharmila Majumdar

Quantifying the Progression of Osteoarthritis with MRI: Quantitative T2 Changes in Articular Cartilage Over a 2 Year Time Period ...... 2550 Adilakshmi Kansal, Kathleen Hughes, Nabile Safdar, George Makris, Alan McMillan, Rao Gullapalli

Fast 3D UTE Imaging of Knee Connective Tissues on a Clinical 3T Scanner ...... 2551 Yongxian Qian, Ashley A. Williams, Constance R. Chu, Fernando E. Boada

New Strategies for Clinical Trials of OA: Evidence from a Longitudinal Trial of Radiography, MRI Morphometry and Molecular MRI...... 2552 Deborah Burstein, Felix Eckstein, Nitya Krishnan

Assessment of the Radial Distribution of Glycosaminoglycans (GAG) in Arthritic Hips Using Delayed Gadolinium Enhanced MRI of Cartilage (DGEMRIC)...... 2553 Jenny Chan, Samir Sur, Inge Kress, Tallal Charles Mamisch, Young-Jo Kim

Three-Dimensional Magnetic Resonance Observation of Cartilage Repair Tissue (3D MOCART) Score Assessed with an Isotropic 3D-True-FISP Sequence at 3.0 Tesla ...... 2554 Goetz Hannes Welsch, Lukas Zak, Tallal Charles Mamisch, Christoph Resinger, Stefan Marlovits, Siegfried Trattnig

Effect of High Tibial Osteotomy on Patellar Cartilage Health: A DGEMRIC Study...... 2555 Agnes G. d'Entremont, Burkhard Madler, Simon Horlick, Mojieb Manzary, Trevor Stone, Robert G. McCormack, David R. Wilson

Repeatability of T1-Quantification in DGEMRIC for Three Different Acquisition Techniques: 2D-Inversion Recovery, 3D Look-Locker and 3D-Variable Flip Angle...... 2556 Carl Siversson, Carl-Johan Tiderius, Paul Neuman, Leif Dahlberg, Jonas Svensson

Repeatability and Age-Related Change of Sodium in the Knee Articular Cartilage Measured with Sodium MRI...... 2557 Seungbum Koo, Ernesto Staroswiecki, Neal Bangerter, Brian Hargreaves, Garry Gold

Deformation of Cartilaginous Collagen Fiber Network Under Pressure: A Load-Bearing MRI Study...... 2558 Nikita Garnov, Wilfried Gründer

Identification of Degenerative Cartilage Through Use of Multiparametric Discriminant Analysis and the Support Vector Machine...... 2559 Ping-Chang Lin, Richard G. Spencer

Validation of Cartilage Thickness Calculations Using Indentation Analysis ...... 2560 Matthew F. Koff, LeRoy Chong, Patrick Virtue, Dan Chen, Timothy Wright, Hollis Potter

Feasibility of Magnetization Transfer Ratio of the Patellar Articular Cartilage at 3T...... 2561 Shuji Nagata, David W. Stanley, Steven L. Williams, Marilyn M. Wood, Joel P. Felmlee, Hiroshi Nishimura, Naofumi Hayabuchi, Kimberly K. Amrami

Longitudinal In Vivo Evaluation of Articular Cartilage Injuries in Small Animals Using Quantitative MR Imaging ...... 2562 Carmen Taylor, Ryan Doan, Alexis Dang, Sharmila Majumdar, C Benjamin Ma

HR-MAS Spectral Analysis of Osteoarthritic Cartilage...... 2563 Sarmad Muneeb Siddiqui, Rahwa Iman, Jan Wooten, John Kurhanewicz, Michael Ries, Xiaojuan Li

MRI Assessment of Matrix Development in Ultrasound-Treated Cartilage Constructs ...... 2564 Onyi Irrechukwu, Ping-Chang Lin, David Reiter, Ligaya Roque, Steve Doty, Richard Spencer, Kenneth Fisbein, Nancy Pleshko

MRI Assessment of Temporal Soft Tissue and Bone Changes in Murine Collagen-Induced Arthritis ...... 2565 Andreas Pohlmann, Victor Musoko, Olga Woolmer, Alison Robinson, Jackie Buckton, Anthony R. Hobson, Michael F. James

Partially Spoiled Dual Echo Steady State Acquisitions (PDESS) ...... 2566 Oliver Bieri, Carl Ganter, Francesco Santini, Klaus Scheffler

Balanced SSFP Profile Asymmetries in Cartilage ...... 2567 Nikola Stikov, Kathryn E. Keenan, Karla L. Miller, Joelle Karine Barral, Garry Evan Gold, John Mark Pauly

Isotropic Imaging of the Wrist at 1.5T Using 3D-FSE-Cube...... 2568 Kathryn Jane Stevens, Grant Charles Wallace, Weitian Chen, Reed F. Busse, Anja CS Brau, Philip J. Beatty, Garry Evan Gold

High-Resolution Uniform Imaging of Finger Joints Using a Dedicated RF Coil at 3.0T...... 2569 Wingchi Edmund Kwok, Zhigang You, Johnny Monu, Gwysuk Seo

A Comparison of Wrist MRI at 3T and 7T Using Adjustable Receiver Arrays ...... 2570 Jurek A. Nordmeyer-Massner, Michael Wyss, Gustav Andreisek, Juerg Hodler, Klaas P. Pruessmann

B1 Inhomogeneity Corrected T1-Quantification for DGEMRIC Using 3D Look-Locker Technique with Non-Slice Selective RF-Pulses...... 2571 Carl Siversson, Carl-Johan Tiderius, Leif Dahlberg, Jonas Svensson

A Noval Algorithem for Eddy Current Effect Reduction in Dixon Method...... 2572 Dongmei Wu, Yongming Dai, Kecheng Liu

Maximizing RF Signal in the Presence of Rapid T2 Relaxation ...... 2573 Michael Carl, Mark Bydder, Atsushi Takahashi, Eric Han, Graeme Bydder

Towards Whole Body Magnetic Resonance Imaging at Ultra-Low Fields ...... 2574 Karlene Rosera Maskaly, Michelle A. Espy, John J. Gomez, Andrei N. Matlachov, Shaun G. Newman, Mark V. Peters, J Henrik Sandin, Larry J. Schultz, Algis V. Urbaitis, Petr L. Volegov, Vadim S. Zotev

Skin Imaging at 7T ...... 2575 Joelle Karine Barral, Ronald D. Watkins, Bob S. Hu, Dwight George Nishimura

A Novel Figure-Eight Coil for Skin Imaging at 7T...... 2576 Stefan Maderwald, Stephan Orzada, Andreas K. Bitz, Oliver Kraff, Irina Brote, Jens M. Theysohn, Mark E. Ladd, Susanne C. Ladd, Harald H. Quick

Assessment of Magnetization Transfer Ratio, Diffusion Weighted Image, and T2-Weighted Image in Human Median Nerve at 3T: Comparison with Carpal Tunnel Syndrome ...... 2577 Shuji Nagata, David W. Stanley, Steven L. Williams, Marilyn M. Wood, Suk-Joo Hong, Joel P. Felmlee, Kimberly K. Amrami

Feasibility of Sagittal T2 Mapping of Human Median Nerve for Localization of Abnormal Region in Patients with Carpal Tunnel Syndrome ...... 2578 Yukari Takeyasu , Takashi Nishii, Tsuyoshi Murase, Toshiyuki Shiomi, Hisashi Tanaka, Youichi Yamazaki, Kenya Murase, Hiroyuki Tanaka, Jyunichi Miyake, Hideki Yoshikawa

Mapping of Intervertebral Disc Long and Short T2 Components at 7T ...... 2579 Chenyang Michael Wang, Mark Elliott, Tom Connick, Walter Witschey, Abram Voorhees, Joe Calabro, Erin McArdle, Ari Borthakur, Ravi Reddy

T2 Mapping as a Potential Biomarker in a Rabbit Model of Intervertebral Disk Damage and Degeneration...... 2580 Harvey Edward Smith, Sukhoon Oh, D Greg Anderson, Patti A. Miller, Yejia Zhang, Lindsi DeArment, Neal Fitzpatrick, Joseph Hong, Todd J. Albert, Alexander R. Vaccaro, Alan S. Hilibrand, Christopher M. Collins

Comparision of Discography Opening Pressure to T1p Relaxation in the Inter-Vertebral Disc in Vivo...... 2581 Matthew Fenty, Walter RT Witschey II, Haris Mohammad, Philip Maurer, Ravinder Reddy, Dawn Elliott, Arijitt Borthakur

High Resolution Isotropic DTI of Human Intervertebral Disc Tissue ...... 2582 Alexander C. Wright, Steve Pickup, Debra Horng, Grace D. O'Connell, Dawn M. Elliott

Quantification of Relaxation Times of Metabolite Resonance in Intervertebral Disc Using MR Spectroscopy ...... 2583 Jin Zuo, Xiaojuan Li, Sharmila Majumdar

MR Spectroscopy in Intervertebral Disc and Correlation with Biochemical Analysis ...... 2584 Jin Zuo, Ehsan Saadat, Adan Romero, Kimberly Loo, Thomas Link, Xiaojuan Li, Sharmila Majumdar

1H Decoupled 13C NMR at 7 Tesla in Humans: Composition of Adipose Tissue ...... 2585 Jimin Ren, Ivan Dimitrov, Thomas Cull, James Murdoch, David Foxall, Dean Sherry, Craig Malloy

Amplification of Achilles Tendon Displacement by a Pivot-Like Restriction Amplifies Final Displacement of Calcaneous and Rotation of Ankle with Possible Impact on Measured Strain ...... 2586 John Hodgson, David Shin, Gajanan Nagarsekar, V Reggie Edgerton, Shantanu Sinha

Pulmonary Perfusion-Weighted Regional Measurements in Mouse – Primarily Results...... 2587 Magdalena Zurek, Katarzyna Cieslar, Monica Sigovan, Amine Bessaad, Emmanuelle Canet-Soulas, Yannick Crémillieux

Towards Routine Lung MRI in Small Animals ...... 2588 Sascha Köhler, Markus Weiger, Ute Molkentin, Franciszek Hennel

MR Imaging and Quantification of Distal Airway Lung Dysfunction ...... 2589 Elan J. Grossman, Ke Zhang, Abe Voorhees, Ken I. Berger, R. M. Goldring, J. Reibman, J. Daugherty, J. Xu, Kelly Anne McGorty, Qun Chen

Measurement of Regional and Global Lung Ventilation Using Non-Rigid Image Registration ...... 2590 Kelvin Chow, Ben Esch, Mark Haykowsky, Ian Paterson, Richard Thompson

Self-Gated 3D FLASH Imaging of the Human Lung Under Free Breathing Using DC Signals...... 2591 Stefan Weick, Markus Oechsner, Martin Blaimer, Felix Breuer, H Köstler, D Hahn, M Beer, Peter M. Jakob

Gravimetric Validation of Lung Density Measured by Multi-Image Gradient Echo Quantitative MRI ...... 2592 Sebastiaan Holverda, Susan Hopkins, Tatsuya J. Arai, G. Kim Prisk, Rebecca J. Theilmann

Quantification of Pulmonary Edema in Heart Failure Patients and Controls with B1-Field Corrected Free- Breathing MRI...... 2593 Kelvin Chow, Jessica Scott, Ben Esch, Mark Haykowsky, Richard Thompson, Ian Paterson

1.5T Vs. 3.0T: Nodule Detection and Semi-Quantitative Assessment of Pulmonary Nodule ...... 2594 Keiko Matsumoto, Yoshiharu Ohno, Hisanobu Koyama, Munenobu Nogami, Daisuke Takenaka,Yumiko Onishi, Nobukazu Aoyama, Hideaki Kawamitsu, Kazuro Sugimura

STIR Turbo SE Imaging Vs. Diffusion-Weighted Imaging: Diagnostic Capability for Quantitatively Assessed N- Stage in Non-Small Cell Lung Cancer Patients...... 2595 Daisuke Takenaka, Yoshiharu Ohno, Yumiko Onishi, Hisanobu Koyama, Munenobu Nogami, Keiko Matsumoto, No Aoyama, H Kawamitsu, Kazuro Sugimura

Diffusion-Weighted Imaging of the Lung Cancers: Preliminary Evaluation of Capability for Detection and Subtype Classification in Pulmonary Adenocarcinomas on Comparison with STIR Turbo SE Imaging ...... 2596 Hisanobu Koyama, Yoshiharu Ohno, Nobukazu Aoyama, Keiko Matsumoto, Yumiko Onishi, Munenobu Nogami, Daisuke Takenaka, Kazuro Sugimura

Comparative Analysis of Predictive Capability for Postoperative Lung Function Among Dynamic Contrast- Enhanced MRI, CT and Nuclear Medicine Study in Non-Small Cell Lung Cancer Patients ...... 2597 Keiko Matsumoto, Yoshiharu Ohno, Hisanobu Koyama, Munenobu Nogami, Daisuke Takenaka, Yumiko Onishi, Nobukazu Aoyama, Hideaki Kawamitsu, Kazuro Sugimura

Compartmental Model Analysis of Oxygen-Enhanced MRI and DCE-MRI Detects Pre-Morbid Lung Damage in Smokers ...... 2598 Deirdre Maria McGrath, Josephine H. Naish, Simon S. Young, Lars E. Olsson, Charles E. Hutchinson, Jorgen Vestbo, John C. Waterton, Chris J. Taylor, Geoff JM Parker

Measurement of Arterial Plasma Oxygenation in Dynamic Oxygen-Enhanced MRI...... 2599 Lucy Elizabeth Kershaw, Josephine Helen Naish, Deirdre M. McGrath, John C. Waterton, Geoffrey James Parker

Analysis of Signal Dynamics in Oxygen-Enhanced MRI...... 2600 Olaf Dietrich, Michael Ingrisch, Ulrike Attenberger, Michael Peller, Konstantin Nikolaou, Maximilian F. Reiser

Dynamic Oxygen-Enhanced Lung MRI: Cross-Correlation Analysis and Oxygen-Activated Pixels ...... 2601 Olaf Dietrich, Ulrike Attenberger, Konstantin Nikolaou, Michael Peller, Maximilian F. Reiser

Early Detection of Pneumonia by 19F MRI...... 2602 Ulrich Flögel, Bernd Ebner, Patrick Behm, Jürgen Schrader

Oxygen-Enhanced MR Imaging: Compared Efficacy of Pulmonary Functional Loss Assessment and Clinical Stage Classification in Asthmatics with Quantitatively Assessed CT ...... 2603 Yoshiharu Ohno, Hisanobu Koyama, Keiko Matsumoto, Yumiko Onishi, Daisuke Takenaka, Munenobu Nogami, Nobukazu Aoyama, Hideaki Kawamitsu, Kazuro Sugimura

Determination of the Safety of Gadobenate Dimeglumine in Pediatric Subjects Referred for Routine Contrast- Enhanced MR Imaging Procedures ...... 2604 Guenther Schneider, Hellmut Schuerholz, Peter Fries, Miles Andrew Kirchin, Marcus Katoh, Arno Buecker

Effect of Intravenous Iron on Nephrogenic Systemic Fibrosis in Rats...... 2605 Thomas A. Hope, Bundit Chaopathomkul, Philip E. LeBoit, Whitney A. High, Victor S. Rogut, Robert J. Herfkens, Robert C. Brasch

Evaluation of Toxicity of Gadolinium Based Contrast Agents on Skin Fibroblasts...... 2606 Rongzuo Xu, Xue-Ming Wu, Eun-Kee Jeong, Zheng-Rong Lu

Longitudinal Intrarenal Oxygenation Estimated by BOLD MRI in a Murine Model of Renal Ischemia Reperfusion Injury ...... 2607 Eva E. de Vries, Marlies Oostendorp, Maarten G. Snoeijs, L. W.E. van Heurn, Walter H. Backes

Blood-Oxygen Level Dependent (BOLD) Imaging in Native and Transplanted Kidneys on 1.5T and 3.0T ...... 2608 Garima Agrawal, Sean B. Fain, Nathan Artz, Andrew L. Wentland, Thomas M. Grist, Arjang Djamali, Elizabeth A. Sadowski

Measurements of Renal Perfusion and Oxygenation in Swine: Preliminary Results...... 2609 Andrew L. Wentland, Nathan Artz, Arjang Djamali, Thomas M. Grist, Garima Agrawal, Sean B. Fain, Elizabeth A. Sadowski

Reproducibility of Diffusion Weighted Imaging at 1.5T and 3T Over a Range of eGFR in Native and Transplant Kidneys ...... 2610 Robert W. Garrett, Garima Agrawal, Karl Vigen, Sean Fain, Thomas Grist, Elizabeth A. Sadowski

Magnetic Resonance Imaging of Body Calcification In Vitro and In Vivo Using Ultra Short Echo Time (UTE) Sequence ...... 2611 Aya Yassin, Ananth J. Madhuranthakam, Ivan Pedrosa, B. Nicolas Bloch, Atsushi Takahashi, Neil M. Rofsky, Robert E. Lenkinski

Detection of Carcinoma in Situ of the Upper Urinary Tract on Dynamic-Enhanced MRI: Superficial Enhancement in Early-Enhanced Phase Images ...... 2612 Masahiro Jinzaki, Eiji Kikuchi, Akihiro Tanimoto, Shigeo Okuda, Hiroaki Sugiura, Kozo Sato, Sachio Kuribayashi

Assessment of Renal Function and Morphology in Potential Living Kidney Donors Using Dynamic Contrast- Enhanced MRI: Initial Results ...... 2613 Cristina Rossi, Andreas Boss, Ferruh Artunc, Serdar Yildiz, Petros Martirosian, Helmut Dittmann, Niels Heyne, Claus D. Claussen, Fritz Schick, Heinz-Peter Schlemmer

DCE-MRI Reveals Functional Changes in Murine Kidneys After Warm Ischemia-Reperfusion Injury ...... 2614 Marlies Oostendorp, Eva E. de Vries, L. W.E. van Heurn, Walter H. Backes

Renal Perfusion and Single-Kidney GFR at 3.0 T Using a 3-Compartment Filtration Model with Reabsorption Correction...... 2615 David L. Buckley, Kola O. Babalola, Constantina Chrysochou, Lucy E. Kershaw, Ching M. Cheung, Timothy F. Cootes, Philip A. Kalra

Multi-Slice Kidney Perfusion Using SE-EPI FAIR: Optimised Acquisition and Analysis Strategies ...... 2616 Alexander Graeme Gardener, Susan Tracy Francis

Renal Perfusion Imaging Using Continuous Arterial Spin Labeling with Separate Labeling and Imaging Coils...... 2617 Adam M. Winchell, Ruitian Song, J Pfeuffer, Ralf B. Loeffler, Claudia M. Hillenbrand

Simultaneous Renal Angiography and Quantitative Perfusion Measurement from a Single Time Resolved MRA Data Set...... 2618 Vikas Gulani, Katherine L. Wright, Yu-Hua Fang, Stephen R. Yutzy, Jeffrey L. Duerk, Mark A. Griswold, Raymond F. Muzic

Non-Contrast Arterial Spin Labeling Approach to Kidney Perfusion: Assessing Reproducibility in Native and Transplanted Kidneys...... 2619 Nathan Artz, Elizabeth Sadowski, Andrew Wentland, Zhifei Wen, Garima Agrawal, Thomas Grist, Arjang Djamali, Sean Fain

True-SEEPAGE: A Tool for Evaluating Renal Perfusion and Function...... 2620 Karan Dara, Jamal J. Derakhshan, Andre Fischer, Stephen R. Yutzy, Nicole Seiberlich, Jeffrey L. Duerk, Mark A. Griswold, Vikas Gulani

Signs of a Tubular Defect Preceding the Impairment of Glomerular Filtration in Alport Mice as Measured by DCE-MRI ...... 2621 Didier Laurent, Farid Sari-Sarraf, Peter O'Donnell, Jennifer Allport-Anderson

Measurement and Comparison of T1 Relaxation Times in Native and Transplanted Kidney Cortex ...... 2622 Yin Huang, Nathan Artz, Zhifei Wen, Elizabeth Sadowski, Sean Fain

Assessment of Kidney Stiffness in a Swine Model of Renal Arterial Stenosis with 7-D MR Elastography ...... 2623 Meng Yin, Lizette Warner, Lilach O. Lerman, Armando Manduca, Richard L. Ehman

In Vivo Localized 1D and 2D MRS of Rat Kidney Using a Clinical 3T MRI/MRS Scanner...... 2624 S. Sendhil Velan, Kevin Engels, Susan Lemieux, Raymond R. Raylman, Vazhaikkurichi M. Rajendran

Quantitative MRI Markers for Cystic Kidney Disease Progression in an ARPKD Rat Model ...... 2625 Chris A. Flask, David Johnson, Vikas Gulani, Rania Osman, Nita Hoxha, Katherine MacRae Dell

MRI Assessment of the Water Distribution in the Ascending Colon in Health and a Model of Diarrhoeal Disease...... 2626 Elisa Placidi, C L. Hoad, L Marciani, E F. Cox, S Pritchard, C Costigan, R C. Spiller, P A. Gowland

In Vivo Detection of Colitis and Colitis-Associated Early Colorectal Tumors in Mice Using Dynamic Contrast- Enhanced Magnetic Resonance Imaging ...... 2627 Devkumar Mustafi, Urszula Dougherty, Marc Bissonnette, Xiaobing Fan, Gregory S. Karczmar, Erica Markiewicz, Marta Zamora

Prospective Comparison of Dark Lumen MR Colonography with Conventional Colonoscopy in Asian Population: Preliminary Results...... 2628 Sudhakar Kundapur Venkatesh, Wai Kit Cheong, Bertrand WL Ang, Lawrence Ho, Christopher Khor

The Use of SPAMM for the Assessment of Motility Patterns in the Small Bowel ...... 2629 Andre M.J. Sprengers, Frank Zijta, Aart J. Nederveen, Frits J. de Bruijn, Rolf M. Lamerichs, Jaap Stoker

Accuracy of MR Enterography Compared to CT Enterography in Young Patients with Bowel Disease ...... 2630 Marianne Michal Amitai, Lisa Raviv -Zilka, Tammar Kushnir, Sara Apter

High Contrast to Noise Ratio (CNR) Using CO2 for Colonic Distension in 3.0 Tesla Magnetic Resonance Colonography (MRC) ...... 2631 Frank Zijta, Aart Nederveen, Jaap Stoker

Carcinoid Tumors of the Small Bowel: Characteristic Imaging Features in MREnteroclysis...... 2632 Christine Schmid-Tannwald, Maximilian Ferdinand Reiser, Christoph Johannes Zech, Karin Anna Herrmann

Quantitative Analysis of Peristaltic and Segmental Motilities in the Rat GI Tract with Dynamic MRI and Spatio- Temporal Maps...... 2633 Amit Ailiani, Thomas Neuberger, Gino Banco, James Brasseur, Nadine Smith, Andrew Webb

MRI Assessment of the Effects of the Physical Form of a Meal on Gastric Emptying, Gallbladder Contraction, Small Bowel Water Content and Satiety...... 2634 Luca Marciani, Nicholas Hall, Caroline L. Hoad, Susan E. Pritchard, Eleanor F. Cox, John J. Totman, Robin C. Spiller, Penny A. Gowland

Preoperative Evaluation of Peritoneal Carcinomatosis Using Multiphasic Dynamic Contrast Enhanced MR- Imaging in Correlation with Complete Surgical Exploration and Histopathology ...... 2635 Bernhard Daniel Klumpp, Ingmar Koenigsrainer, Philipp Aschoff, Matthias Lichy, Claus D. Claussen, Alfred Koenigsrainer, Christina Pfannenberg, Stephan Miller

Assessment of Bowel Inflammation in Crohn’s Disease by Using Quantitative Dynamic Contrast Enhanced MRI ...... 2636 Aytekin Oto, Xiaobing Fan, Devkumar Mustafi, Gregory S. Karczmar, David T. Rubin

Assessment of Tumor Microcirculation in Rectum Carcinoma with Regard to Different Pharmacokinetic Models, Intra- Tumor Heterogeneity and Therapeutic Effects After Neoadjuvant Radio-Chemotherapy ...... 2637 Andreas Markus Hoetker, Peter Mildenberger, Theo Junginger, Christoph Dueber, Torsten Hansen, Matthias Menig, Andreas Pohlmann, Achim Heintz, Katja Oberholzer

Dynamic Perfusion Study of Mouse Pancreas with an Intravascular Contrast Agent...... 2638 Philip Lee, Xavier Golay, George K. Radda

Intraportal Islet Transplantation Assessed by Dynamic Contrast Enhanced Magnetic Resonance Imaging ...... 2639 Nathaniel Chan, Naoaki Sakata, Eba Hathout, Andre Obenaus

Intra-Voxel Incoherent Motion MRI in Rodent Model of Diethylnitrosamine-Induced Liver Fibrosis ...... 2640 Yue Zhang, Ning Jin, Jie Deng, Tamuna Chadashvili, Yang Guo, Guang-yu Yang, Andrew Christian Larson

Quantification of Hepatic Perfusion Fraction Using Diffusion-Weighted Imaging with Multiple B-Values: Utility for the Diagnosis of Liver Cirrhosis ...... 2641 Jignesh Patel, Eric Sigmund, Jens Jensen, Henry Rusinek, Marcel Oei, Bachir Taouli

Assessment of Vendor Dependency of Apparent Diffusion Coefficients – a Phantom Study at 1.5T...... 2642 Sebastian Feuerlein, Axel Bornstedt, Arthur Wunderlich, Saed Boujraf, Volker Rasche

Accuracy of Liver Tumour Apparent Diffusion Coefficients (ADC) Can Be Improved by Selecting Optimised B- Values...... 2643 Matthew Blackledge, Matthew Orton, Dow-Mu Koh, Ben Wilton, Toni Wallace, Matin O. Leach, David J. Collins

SPIO Administration May Increase the Conspicuity of Malignant Liver Nodules on Diffusion Weighted Imaging ...... 2644 Karthik Ganesan, Masoud Shiehmorteza, Ana Almeida, Shay Heaton, Claude Sirlin

Removal of Olefinic Fat Signal in Body Diffusion-Weighted EPI Using a Dixon Method...... 2645 Diego Hernando, Dimitrios C. Karampinos, Kevin F. King, Justin Haldar, John G. Georgiadis, Zhi-Pei Liang

Diffusion-Weighted Imaging Using SS EPI of Abdominal Organs at 3T: Comparison with 1.5T ...... 2646 Andrew Rosenkrantz, Marcel Oei, Hersh Chandarana, Bachir Taouli

Q-Space Imaging of Abdominal Tumor...... 2647 Andreas Lemke, Frederik Laun, Bram Stieltjes, Lothar Rudi Schad

Effect of Number of Shots on the Calculated Apparent Diffusion Coefficient in Phantoms and in Human Liver in Diffusion Weighted Echo Planar Imaging ...... 2648 Masoud Shiehmorteza, Claude Sirlin, Tanya Wolfson, Anthony Gamst, Andre Soumekh, Shay Heaton, Chad Kohl, Nicholas Pinto, Mark Bydder

Effects of Extracellular Hepatobilliary Gadolinium Based Contrast Agents on Apparent Diffusion Coefficient ...... 2649 Manuel Rodriguez, Masoud Shiehmorteza, Karthik Ganesan, Claude Sirlin

Improved Diagnostic Utility of T2-Weighted 3D-TSE Liver Imaging by Suppression of Vascular Signals Using a Motion-Sensitive Preparation ...... 2650 John P. Mugler III, Wilhelm Horger, Berthold Kiefer

Respiratory-Navigated Free Breathing 3D-SPGR Sequence for Contrast-Enhanced Examination of the Liver: Diagnostic Utility and Comparison with Free Breathing and Breath-Hold Conventional Exams ...... 2651 Phillip Young, Anja Brau, Yuji Iwadate, Shreyas Vasanawala, Bruce Daniel, Robert Herfkens

Evaluation of the Relationship Between Respiratory Hepatic and Renal Motion Using Real-Time MRI...... 2652 Aaryani Tipirneni, Ruitian Song, Ralf B. Loeffler, Claudia M. Hillenbrand

Quantitative Multi-Dimensional PROPELLER MRI of Diethylnitrosamine-Induced Hepatocarcinogenesis in Wistar Rat Model ...... 2653 Jie Deng, Ning Jin, Guang-yu Yang, Reed A. Omary, Andrew C. Larson

Liver MR Image Quality: Reducing Anisotropic Noise in Zero-Filled Spin-Warp Imaging ...... 2654 Gregory J. Wilson, Jeffrey H. Maki,

The Hepatic Uptake of Gd-EOB-DTPA Is Strongly Affected by the Hepatobiliary Function...... 2655 Olof Dahlqvist Leinhard, Nils Dahlström, Per Sandström, Anna Freij, Johan Kihlberg, Torkel Brismar, Örjan Smedby, Peter Lundberg

Estimation of Fatty Liver with T2 Correction Using 2D Multiecho-FFE: Human Study Before and After SPIO or Gd-EOB-DTPA Administration ...... 2656 Kengo Yoshimitsu, Hiroshi Honda, Shutaro Saiki, Tomoyuki Okuaki, Marc Van Cauteren

High-Resolution Free-Breathing 3D T1 Weighted Hepatobiliary Imaging Optimized for Gd-EOB-DTPA...... 2657 Scott K. Nagle, Reed F. Busse, Anja C.S. Brau, Jean H. Brittain, Yuji Iwadate, Sina Meisamy, Yu Grace Zeng, Scott B. Reeder

Improved Contrast Enhancement of Experimentally Induced Rat Hepatocellular Carcinoma Using New Blood Pool Contrast Agent Dendrimers DTPA-D1Glc(OH) ...... 2658 Yasuo Takehara, Takashi Aoki, Mitsuji Yamashita, Michio Fujie, Katsuaki Muramatsu, Harumi Sakahara, Norihiro Sadato, Hiroyasu Takeda

Functional Liver Imaging Using Partial Least Squares (PLS) Analysis ...... 2659 Alyaa Hussein Elzibak, Jeff Fortuna, John F. MacGregor, Colm Boylan, Michael D. Noseworthy

Stimulatory Effect of Glucokinase Activation on Hepatic Glycogen Turnover as Measured by 13C-MRS...... 2660 Didier Laurent, Brittany Yerby, Jiaping Gao, Alokesh Duttaroy

MR Elastography: Spleen Stiffness Measurements in Healthy Volunteers...... 2661 Lorenzo Mannelli, Ilse Joubert, Martin Graves, Andrew Patterson, Richard Black, David J. Lomas

Cross-Validation of Magnetic Resonance Elastography and Ultrasound-Based Transient Elastography in Phantom Materials...... 2662 Jun Chen, Jennifer Oudry, Kevin Glaser, Véronique Miette, Laurent Sandrin, Richard Ehman

Molecular MRI of Liver Fibrosis...... 2663 Peter Caravan, Ritika Uppal, Bryan Fuchs, Alexander Guimaraes, George Dai, Tsutomo Fujii, Kenneth Tanabe

Ex-Vivo MR Imaging of Excised Human Livers as a New Method to Reliably Co-Localize Nodules and Nodule Components on Imaging and Pathology: Preliminary 6-Month Experience...... 2664 Karthik Ganesan, Emil Achmad, Irene Mwangi, Chad Kohl, Shalini Ananda, Ana Almeida, Manuel Rodriguez, Michael Peterson, Claude Sirlin

MR Manifestations of Ovarian Clear Cell Adenocarcinomas: A Pictorial Review ...... 2665 Kenji Matsuzaki, Mayumi Takeuchi, Hiromu Nishitani

Detection of Pelvic Lymph Nodes: Diffusion Weighted Imaging Increases Lymph Node Detection Rate When Added to Conventional MRI ...... 2666 Wenche Margrethe Klerkx, Willem Mali, Gerard de Kort, Peter Heintz, Taro Takahara, Daisy Sie-Go, Petra Peeters

Pseudo 3D DWI of the Female Pelvis: A Potential Means of Increasing Staging Accuracy...... 2667 Martin D. Pickles, Lindsay W. Turnbull

Limitations of 3D T2 SPACE for Evaluation of the Female Pelvis at 3.0T...... 2668 Elizabeth Hecht, Silaja Yitta, Ruth Lim, Erin Fitzgerald, Pippa Storey, Kamil Banibaker, Genevieve Bennett

Parallel RF Transmission at 3.0T High-Field MRI: Preliminary Results of High Spatial Resolution Pelvic MRI ...... 2669 Jürgen Gieseke, Winfried A. Willinek, Roy König, Marco Nijenhuis, Guido Kukuk, Romhild Hoogeveen, Barbara Brecher, Magnus Andersson, Eugen Muschler, Andreas Müller, Petra Mürtz, Frank Träber, Wolfgang Block, Daniel Thomas, Christiane K. Kuhl, Hans H. Schild, Nuschin Morakkabati-Spitz

Vascular Bed Volume Change of Uterine Fibroids After GnRHa Treatment: Assessment with Gadolinium- Enhanced Dynamic R2 Imaging ...... 2670 Shigeo Okuda, Koichi Oshio, Akihiro Tanimoto, Hironori Asada, Masahiro Jinzaki, Ayano Akita, Hirotaka Akita, Tomonori Hada, Masataka Furuya, Hiroshi Shinmoto, Yasunori Yoshimura, Sachio Kuribayashi

Signal Intensity Changes During Physiological Movement: Comparison of Uterine Myometrium and Myocardium ...... 2671 Tetsuro Araki, Izumi Imaoka, Kazuhiko Nishimatsu, Masatomo Kuwabara, Yukinobu Yagyu, Masahiro Okada, Taro Shimono, Seishi Kumano, Ryuichiro Ashikaga, Takamichi Murakami

Measuring Blood Movement in the Placenta Using IVIM at 1.5 T...... 2672 Ali Mohammad Al-Radaideh, Vian Kareem, Carolyn Costigan, Nia Jones, Tomas Paus, George Bugg, Penny A. Gowland

DCE-MRI Temporal Resolution Requirements for Vascular Permeability Measurements in Rhesus Macaque Reproductive Tissues...... 2673 Ian J. Tagge, Cecily V. Bishop, Richard L. Stouffer, Charles S. Springer Jr. , Xin Li

MR Quantification of Abnormal Stromal Enhancement in the Periphery of Invasive Breast Tumors ...... 2674 Nima Nabavizadeh, Catherine Klifa, David Newitt, Ying Lu, Jona Hattangadi, Clark Fisher, Nola Hylton, Catherine Park

Comparison of Fibroglandular Tissue Density Evaluated by MRI in Three Different Racial Groups...... 2675 Hoanglong Nguyen, Ke Nie, Jeon-Hor Chen, Chieh-Chih Hsu, Daniel Chang, Sandy Shih, Doris Hsu, Byron Feig, Dustin Newell, Hon J. Yu, Orhan Nalcioglu, Min-Ying Lydia Su

Assessment of Four Different DWI Pulse Sequences Used for Breast Imaging ...... 2676 Martin D. Pickles, Peter Gibbs, Julie Pounder, Lindsay W. Turnbull

Variation of the Apparent Diffusion Coefficient Measured from Various Regions of the Normal Breast Tissue Using Diffusion Weighted MRI as a Function of Various Phases of the Menstrual Cycle ...... 2677 Rani Gupta Sah, Uma Sharma, Rajinder Parshad, Naranamangalam R. Jagannathan

The Effect of B1 Inhomogeneity on Enhancement Ratio Measurements Using DCEMRI of the Breast at 3T...... 2678 C A. Azlan, Trevor S. Ahearn, Gordon D. Waiter, Scott I. Semple, Fiona J. Gilbert, Thomas W. Redpath

High-Resolution, Fat-Suppressed, Diffusion-Weighted MRI of the Breast Using a Self-Navigated Multi-Shot Technique ...... 2679 Wouter B. Veldhuis, Chunlei Liu, Roland Bammer, Bruce L. Daniel, Michael E. Moseley

Benign-Malignant Lesion Differentiation Using Functional ADC-Thresholding – Allowing Expert Radiologist Interpretation – Versus Conventional Thresholding Based on ADC Cut-Off Values...... 2680 Wouter B. Veldhuis, Chunlei Liu, Yung Do, Thomas J. Brosnan, Michael E. Moseley, Bruce L. Daniel

Diagnostic Accuracy of High-Resolution Multi-Shot Diffusion-Weighted MRI for the Detection of Breast Cancer...... 2681 Wouter B. Veldhuis, Chunlei Liu, Yung Do, Michael E. Moseley, Bruce L. Daniel

The Optimized B Value of Breast Diffusion Weighted MRI ...... 2682 Jing Zhang, Liu Quan Cheng, Yong Guo, Fei Sun

Identification of Breast Calcification Using MRI ...... 2683 Ali Fatemi-Ardekani, Michael D. Noseworthy, Colm Boylan

In Vitro MRI Identification and Characterization of Small Calcium Crystals: Implications for Breast Cancer...... 2684 Devkumar Mustafi, Elizabeth Peng, Jeremy Palgen, Jonathan River, Sean Foxley, Gregory S. Karczmar

World of Phantoms: Reference Standards for Bench to Breast MRI ...... 2685 Devkumar Mustafi, Elizabeth Peng, Marieke Heisen, Abbie M. Wood, Johannes Buurman, Gregory S. Karczmar

Three Images from Two Echoes: Reconstruction of Water, Fat and Silicone Images Using a Combined One-Point and Two-Point Dixon Approach. Application to 3D GRE in Breast Implant Imaging...... 2686 Christian Geppert, Valdimir Jellus, Berthold Kiefer

The Effectiveness of a Bisagittal Power Optimisation Approach in the Reduction of B1 Inhomogenity in Breast MRI at 3T...... 2687 C A. Azlan, Pierluigi Di Giovanni, Trevor S. Ahearn, Wim M. Prins, Matthew Clemence, Scott I. Semple, Fiona J. Gilbert, Thomas W. Redpath

Automatic Correction of Intensity Inhomogeneity in Two-Point Dixon Fat and Water Images ...... 2688 Sungheon Kim, Jian Xu, Linda Moy, Henry Rusinek, Daniel K. Sodickson

Effect of B1 Inhomogeneity-Correction on T1-Uniformity in Breast MRI at 1.5 Tesla: Preliminary Results...... 2689 Riham H. El Khouli, David Michael Thomasson, Yuxi Pang, David Bluemke

Kinetic Curves of Malignant Lesions Are Not Consistent Across MR Systems: The Need for Improved Standardization of Breast DCEMRI Acquisitions...... 2690 Sanaz Arkani Jansen, Akiko Shimauchi, Lindsay Zak, Xiaobing Fan, Abbie Wood, Gregory Karczmar, Gillian Newstead

Off-Resonance Effects of Spectrally-Selective Adiabatic Inversion Pulses in Dynamic Contrast-Enhanced Breast Examinations...... 2691 Maria A. Schmidt, Gokhan Ertas, James A. D'Arcy, Anna M. Kirby, Geoffrey S. Payne, David J. Collins, Nandita deSouza, Martin O. Leach

Do Advanced MRI Methods Add Value to Routine Contrast-Enhanced Breast MRI?...... 2692 Frederick Kelcz, Catherine Moran, Karl Vigen, Garima Agrawal, Walter Block

Flexible Four Element Phased Array Coil for Supine Breast MRI ...... 2693 Peter Siegler, Gilbert Thevathasan, Cameron Piron, Helen Marshall, Patrick M. Devine, Donald Bruce Plewes

Evaluation of Multi-Coil Breast Arrays for Parallel Imaging...... 2694 Helen Marshall, Patrick M. Devine, Nishanthan Shanmugaratnam, Cameron Piron, Donald B. Plewes

3D Breast Segmentation for Image Based Shimming...... 2695 Arjan Willem Simonetti, Ronald Holthuizen, Chiel Johannes den Harder, Mathijs Visser, Mark Limkeman

Application of Mammographic Shape Factors to Breast MRI...... 2696 Eric Van Uytven, Hilary Alto, Lawrence Ryner

Evaluation of Automatic Breast MR Anatomy Segmentation ...... 2697 Jean-Michel Rouet, Ursula Kose, Johannes Buurman, Maxim Fradkin, Robert A. Schmidt, Charlene Sennett, Hiroyuki Abe, Gillian M. Newstead

Whole Body Diffusion Weighted Imaging/ADC Mapping and MR Spectroscopy for Detection and Monitoring of Metastatic Cancer at 3T:Preliminary Results...... 2698 Michael A. Jacobs, Li Pan, Katarzyna Macura, Ronald Ouwekerk, Antonio C. Wolff, Vered Stearns, Ihab Kamel, Nouha Salibi, Wilhelm Horger, David Bluemke, Christine Lorenz

B0 Maps Highly Accentuate Spiculations at the Tumor Margin ...... 2699 Milica Medved, Gillian M. Newstead, Hiroyuki Abe, Olufunmilayo I. Olopade, Gregory S. Karczmar

MR-Guided Focused Ultrasound Surgery of Breast Cancer...... 2700 Kiyoshi Namba, Hidemi Furuswa

Development of a Tissue Susceptibility Matched Pyrolytic Graphite Foam for Improved Frequency Selective Fat Suppression in Breast MRI ...... 2701 Gary Chiaray Lee, Patrick Goodwill, Kevin Phuong, Brian Hargreaves, Ben Inglis, Steven Conolly,

Image Based Second Order Shimming for Fat Suppressed Bilateral Breast Imaging at 3T...... 2702 Michael Schär, Riham H. El Khouli, Arjan W. Simonetti, Ronald Holthuizen, David A. Bluemke

Assessment of Errors in T1 Measurement Used for Quantitative DCE-MRI: Consequences for Pharmacokinetic Modelling...... 2703 C A. Azlan, Pierluigi Di Giovanni, Trevor S. Ahearn, Gordon D. Waiter, Scott I. Semple, Fiona J. Gilbert, Thomas W. Redpath

Three Dimensional 1H Magnetic Resonance Spectroscopy in Breast Cancer as an Indicator of Therapy Response. a Pilot Study ...... 2704 Stephan Gruber, Wolfgang Bogner, Marek Chmelik, Katja Pinker, Lothar Ponhold, Martin Krssak, Siegfried Trattnig

Improving the Specificity of Breast MRI with Fuzzy Cluster Analysis ...... 2705 Eric Van Uytven, Iain Kirkpatrick, Lawrence Ryner

Patient-Specific Models of Susceptibility-Induced B0 Field Variations in Breast MRI...... 2706 Caroline D. Jordan, Bruce L. Daniel, Kevin M. Koch, Huanzhou Yu, Steven Conolly, Brian A. Hargreaves

Quantitative MRI Technique for Mapping the T1/T2 Ratios of Benign and Malignant Breast Lesions ...... 2707 M. A. Malikova, Jaroslaw Nicholas Tkacz, Adam Yaakil, Priscilla Slanetz, Hernan Jara

Small-Voxel High Spatial and Spectral Resolution (HiSS) MRI of Human Breast: A Pilot Study ...... 2708 Milica Medved, Gillian M. Newstead, Hiroyuki Abe, Abbie M. Wood, Akiko Shimauchi, Olufunmilayo I. Olopade, Stefan Fischer, Sri Swaminathan, Marko Ivancevic, Gregory S. Karczmar

Susceptibility Weighted Imaging in Breast Tissue: Initial Experiences...... 2709 Catherine Judith Moran, Matthew R. Smith, Frederick Kelcz, Walter F. Block

In Vivo Sodium Imaging and Relaxometry of the Breast at 3T...... 2710 Ernesto Staroswiecki, Anderson Nnewihe, Neal Kepler Bangerter, Bruce Lewis Daniel, Brian Andrew Hargreaves

Spectrally Selective Arterial Spin Labeling Imaging for Breast Cancer Perfusion Study...... 2711 Ka-Loh Li, Yiping Du, Evelyn Proctor, Xiaoping Zhu, Milica Medved, Gregory Karczmar, Nola Hylton

Towards Practical Breast Diffusion Tensor Imaging at 3.0T in the Clinical Setting ...... 2712 Tom Yankeelov, J. Christopher Gatenby, E. Brian Welch, Bapsi Chakravarthy, Darla Freehardt, Ingrid Mayer, Mark Kelley, Ingrid Meszoely, John Gore

Optimizing and Understanding BOLD Contrast Imaging in the Breast ...... 2713 Rebecca Rakow-Penner, Bruce Daniel, Gary Glover

Water/Fat Separation and Off-Resonance Correction for 3T Spiral Breast Imaging...... 2714 Kristin L. Granlund, Bruce L. Daniel, Brian A. Hargreaves

Effect of Fat Spectral Model Parameters on Hepatic Fat Quantification by Multi-Echo Gradient-Echo Magnetic Resonance Imaging...... 2715 Takeshi Yokoo, Mark Bydder, Gavin Hamilton, Michael S. Middleton, Heather M. Patton, Terek Hassanein, Jeffrey B. Schwimmer, Claude B. Sirlin

Diurnal Pattern of Hepatic Fat Content Measured by Magnetic Resonance Imaging in Human Subjects...... 2716 Masoud Shiehmorteza, Yauk Lee, Gavin Hamilton, Michael Schroeder, Irene Mwangi, Julie Collins, Mark Bydder, Takeshi Yokoo, Claude B. Sirlin

Evaluation of Combined Magnetic Resonance and Bioassay Methods for Quantitation of Human Liver Steatosis...... 2717 Yvan Boulanger, Martin Ruel, Abdesslem Khiat, Luigi Lepanto, Miguel Chagnon, Claude Kauffman, An Tang, Louis Gaboury, Gaspard d'Assignies

T1 Effect in Fat Quantification Errors in RF Saturation and IDEAL Gradient Echo Imaging...... 2718 Hing-Chiu Chang, Chun-Jung Juan, Yin-Cheng Kris Huang, Hsiao-Wen Chung

Simultaneous Changes in Liver Volume, Lipid Content and Glycogen Content in Type 2 Diabetes, Obese Subjects and Normal Controls After a Mixed Meal...... 2719 Mary Charlotte Stephenson, Emily Leverton, Eric Y. Khoo, Jane Halliday, Simon M. Poucher, Lars Johansson, Jan W. Eriksson, Roy Taylor, Peter Mansell, Ian A. Macdonald, Peter Gordon Morris

High-Resolution Magic Angle Spinning 1H MRS Detects Lipid Biomarkers in Liver After High Fat Diet...... 2720 Haihui Cao, Jussi Pihlajamaki, Mary-Elizabeth Patti, A Aria Tzika,

Monitoring Hepatic Lipid in Response to CB1R Inverse Agonist Treatment with MRS ...... 2721 Haiying Liu, Richard Z. Chen, Andrea Frassetto, Alise S. Reicin, Richard J. Hargreaves, Donald S. Williams, Tung M. Fong

An Approach to Graphically Evaluate Steatosis in Non-Alcoholic Fatty Liver Disease ...... 2722 Michelle Nystrom, Carl Yuan-Feng Lo, Phil W. Chu, Susan Moyher Noworolski, Aliya Qayyum

The Use of Heavily T1-Weighted Sequences for Fat Quantification ...... 2723 Mark Bydder, Gavin Hamilton, Masoud Shiehmorteza, Chad Kohl, Takehi Yokoo, Michael S. Middleton, Claude Sirlin

MRI Can Quantify Hepatic Steatosis for Treatment Monitoring During Pharmacological Intervention in the ob/ob Mouse...... 2724 Catherine DG. Hines, Huanzhou Yu, Ann Shimakawa, Rashmi Agni, Thomas F. Warner, Jean H. Brittain, Scott B. Reeder,

Liver MRI and MRS for Hepatic Fat Determination in a Multicenter Clinical Trial: Evaluation of Exam Quality in Academic and Non-Academic Centers ...... 2725 Mark Rosen, Sarah Englander, Harish Poptani, Evan Siegelman, James Gimpel, Dena Flamini, Matthew Parris, Bill Sasiela, Bruce Hillman,

High-Throughput Automated Approach to Quantitative Evaluation of Hepatic Fat Fraction in Mice ...... 2726 Brittany Yerby, Yun Jiang, Farid Sari-Sarraf, Jeffrey Tsao

Increase of Intrahepatocellular Lipids (IHCL) During Exercise in Healthy Volunteers...... 2727 Chris Boesch, Andrea Egger, Roland Kreis, Michael Ith, Ina Krull, Jean-Marc Nuoffer, Peter Diem, Christoph Stettler, Emanuel Christ

Assessment of Non-Alcoholic Fatty Liver Disease in Severely Obese Children Using 3.0 Tesla Magnetic Resonance Spectroscopy...... 2728 Jochem Reinier van Werven, B. G. Koot, A. J. Nederveen, M. A. Benninga, O. H. van der Baan, T. H. Pels Rijcken, P. L. Jansen, J. Stoker

Fast Single Breath-Hold 3D Abdominal Spiral Imaging with Water / Fat Separation and Off-Resonance Correction...... 2729 Peter Börnert, Stephan van Zyl, Holger Eggers, Peter Koken

The Effect of J-Coupling on Absolute Quantification of Liver Fat Using MRS: A Phantom Study ...... 2730 Gavin Hamilton, Michael S. Middleton, Masoud Shiehmorteza, Claude B. Sirlin

Characterisation of ANIT-Induced Hepatobiliary Injury in Vivo Using 31P MRS and in Vitro 1H MAS MRS...... 2731 Bhavana Shantilal Solanky, Gina J. Sanchez-Canon, Jeremy F L Cobbold, Simon D. Taylor-Robinson, Jimmy D. Bell, Julie C. Holder, I Jane Cox, Po-Wah So

Comparison of Liver Fat Fraction Measured by MR Spectroscopy at 1.5T and 3T ...... 2732 Gavin Hamilton, Michael S. Middleton, Takeshi Yokoo, Alexander Kuo, Claude B. Sirlin

"Between Weeks" Reproducibility of 3.0 Tesla Magnetic Resonance Spectroscopy for Measuring Hepatic Fat Content...... 2733 Jochem Reinier van Werven, J. M. Hoogduin, A. J. Nederveen, A. A. van Vliet, P. Vandenberk, E. S. Stroes, J. Stoker

The Importance of T2-Correction in Quantifying Liver Fat Using 1H MR Spectroscopy...... 2734 Gavin Hamilton, Michael S. Middleton, Takeshi Yokoo, Joel E. Lavine, Heather M. Patton, Claude B. Sirlin

Free-Breathing Imaging Techniques for Liver Iron Quantification: Comparison with a Validated Breath-Hold Technique in Patients with Iron Overload ...... 2735 Ralf B. Loeffler, Jane Hankins, Ray Song, Adam M. Winchell, Mary Beth McCarville, Claudia M. Hillenbrand

A Comparison Study of Liver R2 Measurement in Pediatric Patients with Iron Overload ...... 2736 Marine Beaumont, Isaac Odame, Paul S. Babyn, Logi Vidarsson, Melanie Kirby-Allen, Hai-Ling Margaret Cheng

Liver T2 Measurement of Iron Overload: An Investigation of Optimal Methods of Quantification...... 2737 Marine Beaumont, Hai-Ling Margaret Cheng

NMR-Based Metabonomics Study on Liver and Kidney Tissues from Type 2 Diabetic Mice...... 2738 Shuhui Cai, James Y. Yang, Jingjing Xu, Jiyang Dong, Zhong Chen

In-Vivo Manganese Enhanced Dynamic Magnetic Resonance Imaging (MEDMRI) to Evaluate Progression of Diabetes in Rodent Pancreas...... 2739 Muhammad Haque, Xiaobing Fan, Erica J. Markiewicz, Lara Leoni, Brian B. Roman

Kinetics of Manganese Chloride in Non-CNS Organs in Mice ...... 2740 Li-Wen Lee, Po-Wah So, Anthony Price, Jane Halliday, Simon M. Poucher, John AT Pugh, Cameron W. McLeod, Jimmy D. Bell

Metabolic Profiles of Urine and Serum from Type 2 Diabetic Mice Detected by 1H NMR Spectra...... 2741 Jingjing Xu, Jiyang Dong, Shuhui Cai, Zhong Chen

Effects of Catch-Up Growth at Early Age on Body Composition...... 2742 Gina Julieth Sanchez Canon, Jelena Anastosovska, Po-Wah So, Neena Modi, Elizabeth Louis Thomas, Jimmy D. Bell

Investigating the Metabolism and Fate of 13C-Hyperpolarized Cis- & Trans-Fatty Acids Via 13C-MRI / MRS ...... 2743 Joachim Bargon, Rahim R. Rizi

The Effect of Stretching Exercise Amplifying Extromyocellular Lipid Signal Intensity in Proton MRS and Its Role in Exercised-Muscle T2w MRI Image...... 2744 Jimin Ren, A. Dean Sherry, Craig R. Malloy

Prolongation of Pancreatic Islet Transplant Viability: Comparison of Preservation Methods by Phosphorus Magnetic Resonance Spectroscopy...... 2745 Alan Bainbridge, Aditya Agrawal, Stephen Powis, Ernest Cady, Barry Fuller, Brian Davidson

Assessment of Metabolism in the Regenerating Mouse Liver by 31P MRSI...... 2746 Khushali Kotedia, Jadegoud Yaligar, Kaitlyn Kelly, Joyce Wong, Jason A. Koutcher, Yuman Fong, Kristen L. Zakian

A 3-Liter Capacity, Hybrid Spin-Exchange 3He Polarizer for Medical Imaging...... 2747 Karen E. Mooney, G. Wilson Miller, Peter A. M. Dolph, William Alexander Tobias, Vladimir Nelyubin, Jaideep Singh, John P. Mugler III, Gordon D. Cates

Optimization of Lung Imaging with Hyperpolarized 3Helium Using a 32 Channel Phased Array ...... 2748 Florian Martin Meise, Julien Rivoire, Maxim Terekhov, Davide Santoro, Sergei Kapuk, Zahir Salhi, Klaus Gast, Wolfgang G. Schreiber

Comparison of Different Parallel Imaging Reconstruction Methods for Hyperpolarized 3He MRI ...... 2749 Julien Rivoire, Florian M. Meise, Maxim Terekhov, Davide Santoro, Zahir Salhi, Wolfgang G.

Comparison of Parallel Image Reconstruction Methods to Acquire High Resolution ADC-Tensor Images of 3He in Human Lungs...... 2750 Maxim V. Terekhov, Julien Rivoire, Florian M. Meise, Davide Santoro, Wolfgang G. Schreiber

Effect of Echo Spacing on the T2 of Hyperpolarized He3 in the Healthy Human Lung at 1.5T ...... 2751 John P. Mugler III, G Wilson Miller, Talissa A. Altes, Jaime F. Mata, Eduard E. de Lange, W Al Tobias, Gordon D. Cates Jr. , James R. Brookeman

SSFP Imaging of Hyperpolarised 3He in the Lungs at 3T...... 2752 Jim M. Wild, Martin H. Deppe, Salma Ajraoui, Kevin Teh, Rob Ireland, Steven R. Parnell, Juan Parra-Robles

Signal-To-Noise Ratio for Hyperpolarized 3He MR Imaging of Human Lungs: A 1.5 T Vs 3 T Comparison ...... 2753 William Dominguez Viqueira, Alexei Ouriadov, Rafael O’Halloran, Sean B. Fain, Giles E. Santyr

Comparison of 3He Ventilation Images at 1.5T and 3T: Increased Apparent Heterogeneity Due to Susceptibility Gradients ...... 2754 Martin Heiner Deppe, Juan Parra-Robles, Salma Ajraoui, Stephen R. Parnell, Matthew Clemence, Rolf F. Schulte, Jim M. Wild

Studies of Weakly Restricted Diffusion Using Hyperpolarized 3He Gas in Cylindrical Cells ...... 2755 Pierre-Jean Nacher, Kajum Safiullin, Geneviève Tastevin

Compressed Sensing: Applications in Hyperpolarised 3He Lung MRI...... 2756 Salma Ajraoui, Kuan J. Lee, Juan Parra-Robles, Martin H. Deppe, Steve R. Parnell, Jim M. Wild

Generating Noble-Gas Diffusion Maps at Very Short Time Scales ...... 2757 Michael Carl, John P. Mugler III, Gordon D. Cates, Wilson Miller

Alveolar-Duct Geometry During Expiration Via 3He Diffusion MRI ...... 2758 Adam Hajari, Dmitriy Yablonskiy, James Quirk, Alex Sukstanskii, Mark Conradi, Richard Pierce, Gaetan Deslee, Jason Woods

Experimental Investigation of Non-Gaussian Diffusion in Hyperpolarized 3He MRI of Lungs ...... 2759 Salma Ajraoui, Juan Parra-Robles, Martin Deppe, Kevin Teh, Steven R. Parnell, John Owers-Bradley, Jim M. Wild

Assessment of Regional Alterations of Lung Function and Structure by Hyperpolarized 3He MRI in a Murine Model of Emphysema...... 2760 Kiarash Emami, John MacDuffie-Woodburn, Charles J. Kotzer, Gregory A. Logan, Stephen Kadlecek, Jianliang Zhu, Stephen Pickup, Jiangsheng Yu, Matthew Stetz, Masaru Ishii, Michael Stephen, Patricia L. Podolin, Rahim Rizi

Regional MR Correlations of Lung Function and Structure in a Rat Model of Emphysema Using Hyperpolarized 3He MRI ...... 2761 Elaine Chia, Kiarash Emami, John MacDuffie-Woodburn, Stephen Kadlecek, Stephen Pickup, Jiangsheng Yu, Masaru Ishii, Jianliang Zhu, Michael Stephen, Rahim R. Rizi

Effects of Application of Positive End Expiratory Pressure on ADC in HP 3He MRI ...... 2762 Laura Carrero González, Thomas Kaulisch, Ignacio Rodríguez, Jose Manuel Pérez Sánchez, German Peces-Barba, Detlef Stiller, Jesus Ruiz-Cabello

Abnormal Ventilation Assessed with Hyperpolarized 3He MRI in Young Cystic Fibrosis Patients with Normal Lung Function. Evaluation of Immediate Influence of a Single Chest Physiotherapy Session ...... 2763 Elise Bannier, Katarzyna Cieslar, Karim Mosbah, Francoise Aubert, Francois Duboeuf, Zahir Salhi, Sophie Gaillard, Yves Berthezène, Philippe Reix, Yannick Crémillieux

Hyperpolarized 3He MRI Heterogeneity and Ventilation Defect Volume Correlates with Asthma Severity ...... 2764 Yanping Sun, Terence Tan, Sanaz Zhalehdoust-Sani, Yang-Sheng Tzeng, Ken Lutchen, Mitchell S. Albert

Using Hyperpolarized 3He MRI to Distinguish Asthmatics from Healthy Subjects ...... 2765 Yanping Sun, Stephen Krinzman, Terence Tan, T. Bishop, A Sosa, S. Rajan, A. Reno, Y-S Tzeng, S. Zhalehdoust-Sani, Kenneth R. Lutchen, J. M. Madison, Mitchel S. Albert

Regional Analysis of Gas Elimination and Redistribution in Lungs During High Frequency Oscillatory Ventilation Studied with Hyperpolarized 3He MRI...... 2766 Maxim V. Terekhov, Alexander W. Scholz, Julien Rivoire, Lars Lillpopp, Ursula A. Wolf, Wolfgang Schreiber

3He NMR Washout Monitoring Combined with 3He Ventilation MRI: Initial Experience in Healthy Volunteers and Cystic Fibrosis ...... 2767 Martin Heiner Deppe, Juan Parra-Robles, Salma Ajraoui, Sean B. Fain, Christopher J. Taylor, Kenny A. Macleod, Alexander R. Horsley, Jim M. Wild

Hyperpolarized 3He MRI of Pulmonary Ventilation in Competitive Breath-Hold Divers During Glossopharyngeal Insufflation and Exsufflation...... 2768 Yanping Sun, James P. Butler, Steve Loring, Peter Lindholm, Jessica Gereige, Ferrigno Massimo, Mitchell S. Albert

Dynamic 3D He-3 MRI for Longitudinal Evaluation of Childhood Asthma...... 2769 James H. Holmes, Rafael L. O'Halloran, Thorsten A. Bley, Christopher J. Francois, Mark L. Schiebler, Robert F. Lemanske, Ronald L. Sorkness, Sean B. Fain

Free Breathing Hyperpolarized 3He Lung Ventilation Spiral MR Imaging. Implementation and Validation on a Clinical Scanner...... 2770 Elise Bannier, Bruno Neyran, Katarzyna Cieslar, Julien Rivoire, Sophie Gaillard, Abdulrazzaq Sulaiman, Emmanuelle Canet- Soulas, Yannick Crémillieux

Hyperpolarized Helium-3 Ventilation and ADC MR Imaging in the Treatment of Patients with Inoperable Lung Cancer...... 2771 Jaime Mata, Ke Sheng, Jing Cai, Paul Read, Talissa Altes, Eduard de Lange, Klaus Hagspiel, William Tobias, Gordon Cates, James Brookeman, John Mugler III

3 Nonlinear pO2 Decay in Human Lungs During Long-Breath-Hold He MRI...... 2772 Juan Parra-Robles, Martin Deppe, Salma Ajraoui, Kevin Teh, Steven R. Parnell, Jim M. Wild

3 HP He-MRI of the Exponential Alveolar pO2 Decay in Human Subjects ...... 2773 Katarzyna Cieslar, Elise Bannier, Zahir Salhi, Sophie Gaillard, Philippe Reix, Yannick Crémillieux

Measurement of the Exponential Decay of Alveolar Partial Pressure of Oxygen Using Hyperpolarized 3He MRI in Animals and Human Subjects...... 2774 Katarzyna Cieslar, Elise Bannier, Philippe Reix, Sophie Gaillard, Emmanuelle Canet-Soulas, Yannick Crémillieux

Combined Proton and HP 3He Oxygen Partial Pressure Mapping for the Evaluation of Acute Respiratory Distress Syndrome...... 2775 Elise Bannier, Katarzyna Cieslar, Sophie Gaillard, Abdulrazzaq Sulaiman, Emmanuelle Canet-Soulas, Yannick Crémillieux

Detection and Evaluation of Impact of Instilled Carbon Nanotubes. a 3-Months Follow-Up Investigation Using Helium-3, Proton Lung MR, Optical and Electronic Microscopy ...... 2776 Achraf Al Faraj, Amine Bessaad, Katarzyna Cieslar, Simone Peyrol, Ghislaine Lacroix, Emmanuelle Canet-Soulas, Yannick Crémillieux

Image Registration for Quantitative Analysis of 3He MRI of the Mouse Lung...... 2777 S. Sivaram Kaushik, Nilesh Mistry, Abraham C. Thomas, Bastiaan Driehuys

Towards Automatic Image Registration of Hyperpolarized 3He MRI and X-Ray CT Images of the Lung ...... 2778 Rob H. Ireland, Neil Woodhouse, James A. Swinscoe, Matthew Q. Hatton, Jim M. Wild

Reproducibility and Volume-Dependency of Regional Measurements of Lung Ventilation by Hyperpolarized 3He MRI ...... 2779 Kiarash Emami, Stephen Kadlecek, John MacDuffie-Woodburn, Jianliang Zhu, Stephen Pickup, Jiangsheng Yu, Matthew Stetz, Masaru Ishii, Michael Stephen, Rahim Rizi

T2 Mapping of Hyperpolarized 3He in the Rat Lung Using a 3D Cones Imaging Strategy...... 2780 Jian-Xiong Wang, Jeffrey A. Stainsby, Alexei V. Ouriadov, Matthew Fox, Giles E. Santyr

Optimization of Regional Measurements of Lung Ventilation in Presence of Uncertain Model Parameters ...... 2781 Kiarash Emami, Jiangsheng Yu, Stephen Kadlecek, John MacDuffie-Woodburn, Jianliang Zhu, Stephen Pickup, Matthew Stetz, Masaru Ishii, Michael Stephen, Rahim Rizi

Modeling Dead Space in Measurements of Pulmonary Ventilation Using Hyperpolarized 3He MRI...... 2782 KiaRash Emami, Masaru Ishii, Stephen Kadlecek, John MacDuffie-Woodburn, Jianliang Zhu, Stephen Pickup, Jiangsheng Yu, Matthew Stetz, Michael Stephen, Rahim Rizi

A Branching-Tree Lung Phantom for Hyperpolarized Noble Gas MRI ...... 2783 Juan Parra-Robles, Salma Ajraoui, Martin Deppe, Kevin Teh, Steven R. Parnell, Jim M. Wild

A 32 Channel Phased Array Lung Coil for Parallel Imaging with Hyperpolarized Xenon 129 at 3T ...... 2784 Isabel Maria Anna Dregely, Graham C. Wiggins, Iulian C. Ruset, John R. Brackett, Steve Ketel, Jan H. Distelbrink, Vijay Alagappan, Azma Mareyam, Andreas Potthast, Jonathan Polimeni, Lawrence L. Wald, Kai Ruppert, Talissa A. Altes, John P. Mugler III, F W. Hersman,

Investigation of Narrowed Lasers and Cell Heating in 129Xe Optical Pumping...... 2785 Steven Richard Parnell, Martin H. Deppe, Stephen Boag, Salma Ajraoui, Juan Parra-Robles, Jim M. Wild

Direct Gas Infusion of Hyperpolarized 129Xe Into Blood—A New Approach to Imaging Pulmonary Perfusion and Gas Exchange...... 2786 Harald E. Möller, Zackary I. Cleveland, Laurence W. Hedlund, Boma Fubara, Gary P. Cofer, Bastiaan Driehuys

Dissolved Phase MR Imaging of Continuously Infused Hyperpolarized 129Xe Using Hydrophobic Gas Exchange Membranes...... 2787 Zackary I. Cleveland, Harald E. Möller, Laurence W. Hedlund, Gary P. Cofer, Boma Fubara, Bastiaan Driehuys

T2 for Hyperpolarized Xe129 in the Healthy Human Lung at 1.5T and 3T ...... 2788 John P. Mugler, III, Isabel M. Dregely, Talissa A. Altes, Stephen Ketel, Iulian C. Ruset, Jan H. Distelbrink, Yulin Chang, Jaime F. Mata, F William Hersman, Kai Ruppert

Q-Space Velocimetery Methods Applied to Flowing Hyperpolarized Xenon...... 2789 Wilson Barros, Ross William Mair, Matthew S. Rosen, Ronald Lee Walsworth

Hyperpolarized 129Xe Lung MRI with TrueFISP on Spontaneous Breathing Mice by Means of Continuous Delivery of Xe Gas Polarized Under Low Pressure...... 2790 Hirohiko Imai, Fumito Imai, Tsuyoshi Ito, Ryosuke Kashiwagi, Toshio Kadobayashi, Atsuomi Kimura, Hideaki Fujiwara

Hyperpolarized Xe129 Ventilation Imaging Using an Optimized 3D Steady-State Free-Precession Pulse Sequence...... 2791 John P. Mugler, III, Talissa A. Altes, Iulian C. Ruset, Stephen Ketel, Jan H. Distelbrink, Yulin Chang, Jaime F. Mata, F William Hersman, Kai Ruppert, Isabel M. Dregely

Chemical Shift Imaging of the Lungs with Hyperpolarized Xe-129: Results from a Rabbit Model of Stereotactic Lung Radiosurgery with and Without a Radioprotector...... 2792 Jaime Mata, Ke Sheng, Paul Read, Kai Ruppert, Klaus Hagspiel, Talissa Altes, William Tobias, Gordon Cates, James Brookeman, John Mugler III

Detection of Parameters Related to Lung Functions and Structures as Applied to Emphysema Model Mice with Hyperpolarized 129Xe MRS Observed Under Spontaneous Respiration...... 2793 Hirohiko Imai, Shoko Masuda, Tsuyoshi Ito, Yuki Hori, Atsuomi Kimura, Hideaki Fujiwara

Experimental Measurements and Computer Simulation of Long-Time-Scale Hyperpolarized 3He and 129Xe Diffusion in Human Lungs ...... 2794 Chengbo Wang, Sylvia Verbanck, John P. Mugler, III, Kai Ruppert, Eduard E. de Lange, F W. Hersman, Isabel M. Dregely, Iulian Runset, Stephen Ketel, Talissa A. Altes

Xenon Surface Relaxivity: Potential Applications to Probing Lung Disease ...... 2795 Xin Zhou, Louis -S Bouchard, David Trease, Nick Halpern-Manners, Alexander Pines,

In Vivo Proton 1.5-T MR Spectroscopy of the Breast Using the Total Choline Peak Integral as a Marker of Malignancy...... 2796 Giovanni Di Leo, Alfonso Fausto, Robin de Nijs, Franca Podo, Marianne Vorbuchner, Francesco Sardanelli

Combining Data from HR MAS MR Spectroscopy and Gene Expression Can Refine the Subclassification of Breast Cancer...... 2797 Eldrid Borgan, Beathe Sitter, Tone Frost Bathen, Steinar Lundgren, Hilde Johnsen, Ole Christian Lingjærde, Therese Sørlie, Anne- Lise Børresen-Dale, Ingrid Susann Gribbestad

Classification and Prediction of Prognostic Factors of Breast Cancer Patients by MR Metabolomics ...... 2798 Guro Fanneløb Giskeødegård, Steinar Lundgren, Beathe Sitter, Hans Fjøsne, Jostein Halgunset, David E. Axelson, Ingrid Susann Gribbestad, Tone Frost Bathen

Early Prediction of Nodal Status Following Neoadjuvant Chemotherapy Treatment of Breast Cancer Utilising MR Parameters ...... 2799 Martin D. Pickles, Gary P. Liney, Martin Lowry, Lindsay W. Turnbull

Diffusion Weighted Imaging, ADC Mapping, and Sodium MR Imaging of Operable Breast Cancer After Neoadjuvant Therapy: Preliminary Results...... 2800 Michael A. Jacobs, Ronald Ouwekerk, Vered Stearns, Katarzyna Macura, Antonio C. Wolff, Riham El Khouli, Ihab Kamel, David Bluemke

Multinuclear and Multiparametric MR Imaging as an Early Treatment Response Biomarker for Preoperative Systemic Therapy in Breast Cancer:Preliminary Results ...... 2801 Michael A. Jacobs, Ronald Ouwekerk, Antonio C. Wolff, Vered Stearns, Katarzyna Macura, Ihab Kamel, Zaver M. Bhujwalla, David Bluemke

Evaluation of Computer Aided 3D Parametric Analysis of MR-Mammography for Follow-Up Assessment of Malignant Lesions Under Primary Systemic Therapy...... 2802 Lale Umutlu, Stefan Maderwald, Till A. Heusner, Sherko Kuemmel, Rainer Kimmig, Elke Hauth, Michael Forsting, Thomas C. Lauenstein

Studying Breast Tumour Heterogeneity with a Fractal Analysis Tool, a Prognostic Indicator of Tumour Pathological Response Before Chemotherapy Treatment ...... 2803 Pierluigi Di Giovanni, Scott IK Semple, Roger T. Staff, Thomas W. Redpath, Fiona J. Gilbert

Parametric Response Mapping: A Voxel-Based Analysis of Quantitative Diffusion MRI Changes for Individualized Assessment of Primary Breast Cancer Response to Therapy...... 2804 Chuck Meyer, Thomas Chenevert, Craig Galban, Timothy Johnson, Daniel Hamstra, Alnawaz Rehemtulla, Brian Ross

Multisequence and Multiplanar Whole Body MRI for Detection of Cancer Metastases...... 2805 Jingfei Ma, Colleen Costelloe, John Madewell, Gabriel Hortobagyi, Marjorie Green, Guang Cao, Fei Sun, Vikas Kundra

Contrast-Enhanced Magnetic Resonance Mammography for Screening of the Controlateral Breast in Patients with Diagnosed Breast Cancer ...... 2806 Federica Pediconi, Sabrina Cagioli, Valeria Dominelli, Maria Laura Luciani, Valeria Martino, Carlo Catalano, Roberto Passariello

A Capillary Input Function for Pharmacokinetic Analysis of DCE-MRI Breast Cancer Curves ...... 2807 William Kieron Lloyd, Thomas W. Redpath, Trevor S. Ahearn, Scott I. K. Semple, Fiona J. Gilbert

trans Breast Tumour DCE-MRI in Presence of B1 Inhomogeneity, Effect on K /ve Using T1-Weighted FLASH ...... 2808 Pierluigi Di Giovanni, Che A. Azlan, Thomas W. Redpath, Trevor S. Ahearn, Scott IK Semple, Fiona J. Gilbert

trans Quantifying Changes in Breast Tumour K /ve Parameters When Reducing Temporal Resolution of Contrast Enhanced Dynamic MRI ...... 2809 Pierluigi Di Giovanni, Thomas W. Redpath, Scott IK Semple, Trevor S. Ahearn, Fiona J. Gilbert

Quantitative Analysis of Breast Parenchymal Patterns Using 3D Fibroglandular Tissues Segmented Based on Breast MRI...... 2810 Ke Nie, Jeon-Hor Chen, Chieh-Chih Hsu, Hoanglong Nguyen, Muqing Lin, Tzu-Ching Shih, Dustin Newell, Byron Feig, Orhan Nalcioglu, Min-Ying Lydia Su

Comparison of Breast Density in the Contralateral Normal Breast of Patients with Different Types of Breast Cancer Measured on MRI...... 2811 Jeon-Hor Chen, F-T Hsu, H-N Shih, C-C Hsu, Daniel Chang, K Nie, O Nalcioglu, M-Y Su

Functional Connectivity and Arterial Spin Labeling in Chemotherapy Induced Cognitive Impairment ("Chemobrain") ...... 2812 Peter S. LaViolette, William Collier, Kathleen M. Schmainda, L Piacentine, K L. Douville, C R. Chitambar, A Tran, S A. Claesges, S J. Durgerian, Alan S. Bloom

Optimization of Registration of Parametric Gd-DTPA MR with Parametric F-18-FDG PET/CT Images for Improved Breast Cancer Detection ...... 2813 Andrzej Krol, Alphonso Magri, David Feiglin, Gwen Tillapaugh-Fay, Wendy McGraw, Edward Lipson, James Mandel, Wei Lee

Comparison of Gleason Scores and MR Spectroscopic Imaging in Prostate Cancer Patients...... 2814 Nagarajan Rajakumar, Ana Maria Gomez, Daniel Margolis, Steven S. Raman, Timothy McClure, Michael Albert Thomas

Value of Multiparametric MRI in Prostate Cancer ...... 2815 Anja Maria Weidner, Henrik J. Michaely, Andreas Lemke, Lutz Breitinger, Maurice S. Michel, Frederik Wenz, Natascha Schnitzer, Stefan O. Schönberg, Dietmar Jörg Dinter

DCE of the Prostate:Contrast Enhancement Correlates to Glandular Lumen ...... 2816 Tryggve Holck Storaas, Kjell-Inge Gjesdal, Jonn-Terje Geitung, Aud Svindland

Proton and Sodium MR Imaging of Prostate Using a Dual-Tuned Endorectal Coil at 3 T...... 2817 Kyongtae Ty Bae, Chan Hong Moon, George J. Misic, Jung-Hwan Kim, Sung-Hong Park, Tiejun Zhao

Alignment of Digitized Whole-Mount Histopathology Slides to Prostate MR Images...... 2818 Susan M. Noworolski, Richard F. Guo, Galen D. Reed, Kyle Kuchinsky, Kirsten Greene, Peter Carroll, Daniel B. Vigneron, John Kurhanewicz, Jeffry Simko

High-B-Value Diffusion-Weighted Imaging at 3T for Detection of Prostate Cancer ...... 2819 Yoshimitsu Ohgiya, Takashi Hashizume, Junpei Suyama, Noritaka Seino, Syu Takaya, Masaaki Kawahara, Makoto Saiki, Masanori Hirose, Takehiko Gokan

High Spatial and Spectral Resolution (HiSS) MRI of the Prostate: A Pilot Study ...... 2820 Milica Medved, Aytekin Oto, Gregory S. Karczmar

3T DCE MRI in Prostate Cancer – Comparison Between Population Average and Patient Specific Arterial Input Function...... 2821 Ran Meng, Burkhard Meadler, Silvia D. Chang, Edward C. Jones, S Larry Goldenberg, Piotr Kozlowski

MR-Histology Correlation in Ex-Vivo Human Prostate Specimens...... 2822 Simon Yoon Kimm, Jin Hyung Lee, Dwight G. Nishimura, Tatum V. Tarin, Bob S. Hu, Kristen Jensen, James D. Brooks

Utility of Quantitative T2 Signal Intensity and ADC Measurements in Differentiating Prostate Cancer from Post- Biopsy Hemorrhage...... 2823 Andrew Rosenkrantz, Martin Kopec, Xiangtian Kong, Jonathan Melamed, Bachir Taouli

Assessment of Registration Accuracy Between Magnetic Resonance Imaging and Three Dimensional Trans-Rectal Ultrasound Imaging of Prostate Cancer ...... 2824 Elmer Soto, Vaishali Karnik, Igor Gyacskov, Lori Gardi, Tamie L. Poepping, Gord John Campbell, Aaron Fenster, Charles Alexander McKenzie

A Voxel-By-Voxel Benchmark Comparison Between Two in Vivo Prostate MRSI Techniques ...... 2825 Niranjan Venugopal, Boyd McCurdy, Salem Al Mehairi, Abdulaziz Alamri, Gurdarshan Singh Sandhu, Darrel Drachenberg, Lawrence Ryner

Combined Prostate DTI and DCE MRI at 3T – Correlation with Biopsy...... 2826 Piotr Kozlowski, Ran Meng, Burkhard Meadler, Silvia D. Chang, Edward C. Jones, S Larry Goldenberg

Independent Component Analysis of Dynamic Contrast-Enhanced Magnetic Resonance Images of Prostate Tumours ...... 2827 Tong San Koh, Choon Hua Thng, Septian Hartono, David Collins, Sophie Richards, Martin O. Leach, Aslam Sohaib, David Dearnaley, Dow-Mu Koh

MRI/TRUS Fusion for Prostate Biopsy: Early Results and Clinical Feasibility...... 2828 Ramkrishnan Narayanan, John Kurhanewicz, Katsuto Shinohara, David Crawford, Albaha Barqawi, Anne Simoneau, Jasjit Suri

A Comparison of Arterial Input Functions Derived from Phase and Magnitude for Quantitative DCE-MRI of the Prostate ...... 2829 Greg O. Cron, Claire Foottit, Thomas E. Yankeelov, Leonard I. Avruch, Ian Cameron

Correlation of MR Imaging Guided Prostate Biopsy Determined Gleason Grade and True Gleason Grade in Radical Prostatectomy Specimens ...... 2830 Caroline Hoeks, Thomas Hambrock, Diederik Somford, Jurgen Futterer, Christina Hulsbergen-van de Kaa, Inge van Oort, Alfred Witjes, Jelle Barentsz

MR Diffusion-Weighted Imaging in Prostate Cancer:A Valuable Tool for MRGuided Biopsy? ...... 2831 Matthias C. Roethke, Matthias P. Lichy, Alexander Pelzer, Claus H. vonWeyhern, David Schilling, Claus D. Claussen, Heinz P. Schlemmer

Multiparametric 3T MR Imaging for Detection of Prostate Cancer with Surgical Correlation...... 2832 Baris Turkbey, Haresh Mani, Marcelino Bernardo, Yuxi Pang, Kiranpreet Khurana, Paul Albert, Peter Pinto, Maria Merino, Peter L. Choyke

Correlation of Endorectal 2D JPRESS Findings with Pathological Gleason Scores in Prostate Cancer Patients...... 2833 Nagarajan Rajakumar, Daniel Margolis, Steven S. Raman, Ana Maria Gomez, Timothy McClure, Nader Binesh, Michael Albert Thomas

Feasibility of Chemical Exchange Saturation Transfer (CEST) MRI for Prostate Cancer Detection at 3T ...... 2834 Guang Jia, Jinyuan Zhou, Seongjin Choi, Wenbo Wei, Steffen Sammet, Jiachao Liang, Jun Zhang, Zarine K. Shah, Mitva Patel, Ronney Abaza, Pankaj Dangle, Douglas Martin, Michael V. Knopp

Correlation Between 3T MRI Apparent Diffusion Coefficient Values and Prostate Cancer Gleason Score in Prostatectomy Specimens ...... 2835 Caroline Hoeks, Thomas Hambrock, Diederik Somford, Henk-Jan Huisman, Christina Hulsbergen-van de Kaa, Inge van Oort, Alfred Witjes, Jelle Barentsz

Retrospective Analysis of Prostate Cancer Recurrence Potential with Tissue Metabolomic Profiles...... 2836 Andreas Maxeiner, Christen B. Adkins, W. Scott McDougal, Chin Lee Wu, Leo Ling Cheng

Optimum Spatial Resolution and Number of Averages of Diffusion Tensor Imaging in Prostate Cancer Detection ...... 2837 Yu-Jen Chen, Y-S Pu, S-C Chueh, C-T Shun, W-C Chu, W-Y Isaac Tseng

Histologic Basis of MRI in Prostate Peripheral Zone: Determination of the Relationships Between Sub-Cellular Components and ADC, T2, Ktrans and Ve ...... 2838 Deanna Lyn Langer, Theo H. van der Kwast, Andrew J. Evans, John Trachtenberg, Brian C. Wilson, Masoom A. Haider

Correlation of Phospholipid Metabolites with the Proliferation Marker Ki-67 in Prostate Cancer Tissues...... 2839 Haris Tsachres, Kayvan Keshari, Carissa Santos, Lynn DeLosSantos, Laura Tabatabai, Jeffry Simko, Katsuto Shinohara, Peter Carroll, Dan Vigneron, John Kurhanewicz

Heterogeneity of Vascular Permeability in Breast Lesions with Dynamic Contrast Enhanced MRI ...... 2840 Chihwa Song, Matthew Robert Smith, Yin Huang, Robert Jeraj, Sean Fain

Adaptive Clustering of MR Diffusion Parameter Space for Brain Tumor Tissue Characterization ...... 2841 Priya Goel, Matthias Karrasch, Jan A. den Hollander, James Macdowell Markert, Louis Burt Nabors, Narsimha Shastry Akella

Integration of 3.0T MRI Into a Radiation Oncology Department: Initial Experience...... 2842 William H. Hinson, Traci E. Ball, Wendy M. Dolesh, Laila F. Graham, Edward G. Shaw, J. Daniel Bourland, William T. Kearns, Michael T. Munley, Allan F. deGuzman

Non-enhancing Pixels: A Specific Additional DCE-MRI Kinetic Parameter for Assessing Antivascular Effects of Anti-Angiogenic and Vascular Disruptive Agents ...... 2843 N. Jane Taylor, Nina Tunariu, J James Stirling, David J. Collins, Paul Nathan, James A. d'Arcy, Mei-Lin W. Ah-See, Andreas Makris, Ian Judson, Martin O. Leach, Dow-Mu Koh, Anwar R. Padhani

Rectal Cancer Staging with High-Resolution 3D Imaging Sequences...... 2844 Tobias Baumann, Markus Treier, Axel Zur Hausen, Matthias Langer, Arnd-Oliver Schäfer

Investigation of a Logistic Model for T2 Dynamic Susceptibility Weighted (DscMRI) Perfusion Studies ...... 2845 Graeme M. Wardlaw, Raimond Wong, Colm Boylan, Ryan Rebello, Michael D. Noseworthy

The Implication of Assuming a Linear Relationship Between MR Signal and Contrast Agent Concentration for Evaluating the Drug Effects for DCE-MRI...... 2846 Poe-Jou Chen, A. Gregory Sorensen

Partial Volume-Related Errors in Parameters Derived from Dynamic Contrast-Enhanced MRI – Implications for Clinical Trials...... 2847 Anita Banerji, Yvonne Watson, Caleb Roberts, Angela Caunce, Giovanni A. Buonaccorsi, Geoff J. Parker

Simultaneous Quantification of Heterogeneity in Multiple DCE-MRI Parameters...... 2848 Chris James Rose, James Patrick O'Connor, Yvonne Watson, Caleb Roberts, Giovannni A. Buonaccorsi, Susan Cheung, Brandon Whitcher, Geoffrey J. Parker

The Microvascular Characteristics of Cervical Cancer: Limitations of the Modified Tofts Tracer Kinetic Model for the Analysis of DCE-MRI Data ...... 2849 Stephanie B. Donaldson, Catharine M.L. West, Susan E. Davidson, Bernadette M. Carrington, Gillian Hutchison, Steven P. Sourbron, David L. Buckley

Comparison of Perfusion Parameters in Normal and Metastatic Bone Marrow Using DCE-MRI and Pharmacokinetic Modeling: A Reference Study...... 2850 Nicolas Michoux, Paolo Simoni, Bertrand Tombal, Frank Peeters, Xavier Banse, Jean-Pascal Machiels, Frédéric Lecouvet

Comparison of DCE-MRI and DCE-CT in Bladder Cancer...... 2851 Josephine Helen Naish, Deirdre M. McGrath, Lauren J. Baines, Katia Passera, Caleb Roberts, Sue Cheung, M Ben Taylor, John P. Logue, David L. Buckley, Jean Tessier, Helen Young, John C. Waterton, Geoff J. Parker

Statistical Comparison of Tofts-Model Parameters with Descriptive and Approximated Descriptive Parameters ...... 2852 Hendrik Oliver Arp Laue, Christian M. Zechmann, Patrik Zamecnik, Horst Karl Hahn, Heinz-Otto Peitgen

Nonparametric Kinetic Analysis of DCE-MRI Images Taken from Glioblastoma Patients ...... 2853 Gregory Z. Ferl, Michel Friesenhahn, Lisa J. Bernstein, Daniel P. Barboriak, Ruediger E. Port

Dynamic Contrast Enhanced Magnetic Resonance Imaging Analysis of Different Head and Neck Cancers ...... 2854 Kar-ho Francis Lee, Ann Dorothy King, Ka-Wai Yeung, Buig-yue Ma, Kwok-Hung Yu, Kunwar Bhatia, Anil Ahuja

Semi-Parametric Analysis of Gd-DTPA Kinetics in Glioblastoma...... 2855 Ruedi E. Port, Lu Xu, Lisa J. Bernstein, Timothy P. L. Roberts, Daniel P. Barboriak, Nicholas van Bruggen

Comparison of Perfusion-Weighted Imaging Techniques in a Clinical Setting Using Dynamic Susceptibility Contrast Enhanced MRI with Automated Localized Arterial Input Function Selection Versus Manual Global Arterial Input Function Selection...... 2856 Adam M. Winchell, Ulrike Lobel, Jan Sedlacik, Ralf Loeffler, Zoltan Patay, Michael Hamm, Claudia Hillenbrand

Characterization of Angiogenic Subtypes of Oligodendroglioma by MR-Perfusion Imaging ...... 2857 Gurpreet Singh Kapoor, Timothy Gocke, Sanjeev Chawla, Ali Nabavizadeh, Robert G. Whitmore, Harish Poptani, Joanna Lopinto, Justin Plaum, Eileen Maloney-Wilensky, Elias R. Mehlem, Donald M. O'Rourke

Local Arterial Input Fucntions in DCE-MRI...... 2858 Jacob U. Fluckiger, Matthias C. Schabel, Edward VR DiBella

To Assume or Not to Assume Blood T1 for AIF Measurement in DCE-MRI?...... 2859 Caleb Roberts, David L. Buckley, Geoff J. Parker

Automated Principal Component Analysis (PCA) Filtering for Denoising DCEMRI Data...... 2860 Balvay Daniel, Nadjia Kachenoura, Isabelle Thomassin, Rokhaya Thiam, Laure Fournier, Yves Rozenholc, Charles André Cuenod

Simulation Studies of Impulse Response Functions for DCEMRI: Comparing a New Mathematical Model with a Single Exponential Decay Function in the Two-Compartment Model...... 2861 Xiaobing Fan, Gregory S. Karczmar

Can Contrast Extravasation Be Separated from Intravascular Recirculation in DSC MRI of the Brain?...... 2862 Yi-Ying Wu, Ho-Ling Liu

Analysis of Vascular Function by DCE-MRI in a Human Endothelial Cell Derived Angiogenesis Model in Mice...... 2863 Claudia Weidensteiner, Wilfried Reichardt, Holger Weber, Dominik Paul, Oliver Siedentopf, Christoph Schaechtele, Dominik von Elverfeldt

Parameter Fits Using Measured Population AIF Vs. Literature AIF in DCE-MRI of Pancreatic Cancer Xenograft Model ...... 2864 Andrew C.H. Yung, Sylvia Ng, Jennifer Flexman, Jenny C.H. Tso, Donald Yapp, Piotr Kozlowski

Evaluation of Functional and Structural Characteristics of Tumor Angiogenesis in Lung Cancer Overexpressing Different VEGF Isoform in a Murine Xenograft Model by Using of MR Imaging ...... 2865 Chia-Ming Shih, Ang Yuan, Chih-Yuan Chen, Hao-Wei Cheng, Chien-Yuan Lin, Pan-Chyr Yang, Jyh- Horng Chen, Chen Chang

An Improved Reference Tissue Approach for Measuring the Arterial Input Function in DCEMRI; Comparison of Late-Phase Reference Tissue and Plasma Contrast Media Concentrations...... 2866 Xiaobing Fan, Chad R. Haney, Devkumar Mustafi, Marta Zamora, Erica J. Markiewicz, Gregory S. Karczmar

Simultaneous Determination of Blood Flow, Microvascular Permeability and Blood Volume in Lung Cancer Overexpressing Different VEGF Isoforms in a Murine Xenograft Model by Dynamic Contrast Enhancement MR Imaging (DCE-MRI) ...... 2867 Chia-Ming Shih, Ang Yuan, Chih-Yuan Chen, Hao-Wei Cheng, Ta-Wei Chou, Pan-Chyr Yang, Jyh-Horng Chen, Chen Chang

Exploring Optically-Derived Uptake Functions in the Context of Dynamic Contrast-Enhanced MRI Arterial Input Function Measurement ...... 2868 Ross A. Little, Marietta Scott, Jane Halliday, Geoff J. Parker

Comparing Single-Shot Look Locker T1 Mapping and Dynamic 3D T1-Weighted Gradient Echo Imaging for Free Breathing Quantitative DCE-MRI in a Rat Liver Tumor Model at 1.5 T...... 2869 Andreas Steingoetter, Jonas Svensson, Stefanie Remmele, Rene Botnar, Markus Schwaiger, Ernst Rummeny, Rickmer Braren

Dual-Relaxation, Temporally-Constrained, Dynamic Contrast-Enhanced MRI Using Inversion Recovery TrueFISP ...... 2870 Simon Walker-Samuel, Matthew Orton, Lauren C. Baker, Jessica K. Boult, Simon P. Robinson

Perfusion Changes Following EGFR Targeted Hollow Gold-Nanoshell Mediated Heating of Tumors ...... 2871 Anil Shetty, Marites P. Melancon, Andrew Elliott, Qian Huang, Xiaoxia Wen, Chun Li, John D. Hazle, R Jason Stafford

Interrogation of Fluctuating Tumour Microvasculature Using Combined Carbogen-USPIO (CUSPIO) Imaging...... 2872 Jake Samuel Burrell, John C. Waterton, Anderson Ryan, Simon P. Robinson, Simon Walker-Samuel

The Utility of Gd-DTPA Labeled Red Blood Cells as a Contrast Agent for DSCMRI Studies...... 2873 S. Nicole Driggins, John Gore, C. Chad Quarles

Simultaneous Dynamic Contrast-Enhanced MRI of Four Mice with Induced Tumors on a 1.5 T Clinical Scanner...... 2874 Stefan Fischer, Stefan Weber, Kerstin Münnemann, Florian M. Meise, Jürgen Brieger, Wolfgang G. Schreiber

Prostate Volume in Sexually Immature and Mature Dogs as Measured by MRI...... 2875 Paul J. McCracken, Marie Holahan, Stephanie Born, Sairam Bellum, Nicholas Gatto, Donald S. Williams

Assessing Thermal Damage Using Dynamic Contrast Enhanced MRI...... 2876 Steffen Lund Hokland, Thomas Nielsen, Chrit T. W. Moonen, Hans Stødkilde-Jørgensen, Michael R. Horsman, Michael Pedersen

Magnetic Resonance Imaging Demonstrating Reduction of Edema by Anti-Angiogenic Treatment in a Brain Metastasis Mouse Model...... 2877 Luhua Zhang, Jeeva Munasinghe, Juan Juan Yin, Alan Koretsky, Kathleen Kelly

RAFF Contrast During Gene Therapy of Rat Brain Tumors: Association with Cell Density in Tissue Undergoing Apoptotic Cell Death ...... 2878 Timo Liimatainen, Alejandra Sierra-Lopez, Timothy Hanson, Dennis J. Sorce, Michael Garwood, Shalom Michaeli, Olli Gröhn

Mechanisms of Apparent Diffusion Coefficient Change at Early and Late Stages of Apoptosis...... 2879 Colleen Bailey, Anoja Giles, Gregory J. Czarnota, Greg J. Stanisz,

Molecular Magnetic Resonance Imaging: Implications to the Detection of Apoptosis ...... 2880 Patrick Rapley, Katy Lynn Rich, Mary Lynn Tassotto

Dynamic Contrast-Enhanced MR Imaging Detected Early Changes in Vascular Permeability Following Anti-DR5 Antibody Therapy in Breast Tumor Xenografts...... 2881 Hyunki Kim, Karri Folks, Lingling Guo, James George, Yanhui Sun, Kurt Zinn

Optimization of Bevacizumab Dosing in Brain Tumors Using MRI Measures of Enhancing Tumor Volume and Relative Cerebral Blood Volume ...... 2882 Kimberly R. Pechman, Shekar N. Kurpad, Deborah L. Donohoe, Devyani P. Bedekar, Kathleen M. Schmainda

Changes in Breast Tumor Kps and ADC After Treatment with the VEGFR-TK Inhibitor AG-013736 Correlate with Changes in Tumor Volume...... 2883 Lisa J. Wilmes, Ka-Loh Li, Lisa M. Fleming, Maria G. Pallavicini, Savannah C. Partridge, Sheye Aliu, Nola M. Hylton

Effect of Vascular Targeting on Tumor Vessel Volume and Size Distribution...... 2884 Thomas Nielsen, Lise Bentzen, Michael Pedersen, Michael Robert Horsman, Leif Østergaard

Improvement of Colorectal Liver Metastases Detection Sensitivity and Specificity by Hemodynamic Response Imaging Combined with a Machine Learning Approach ...... 2885 Yifat Edrei, Moti Freiman, Eitan Gross, Nathalie Corchia, Leo Joskowicz, Rinat Abramovitch

Fiducial Markers for Correlation of Whole-Specimen Histopathology with MR Imaging at 7T ...... 2886 Deirdre Maria McGrath, Roxana M. Vlad, Warren D. Foltz, Kristy K. Brock

Pattern of Mobile Lipid Accumulation in HeLa Cells During Paclitaxel-Induced Cell Death Using Diffusion- Weighted Spectroscopy...... 2887 Dominik Zietkowski, Thomas R. Eykyn, Geoffrey S. Payne, Nandita M. de Souza

VEGF Overexpression in MCF-7 Breast Cancer Cells Increases Invasion and Lactate Production ...... 2888 Tariq Shah, Flonne wildes, Venu Raman, Zaver M. Bhujwalla

Hyperammonia and Hypoxia Induce Relevant Changes in Lipid Signals in 1H NMR Spectra from Human Cancer Cells...... 2889 Sveva Grande, Anna Maria Luciani, Alessandra Palma, Antonella Rosi, Orazio Sapora, Vincenza Viti, Laura Guidoni

Mitochondrial Dysfunction Induces Mobile Lipids and Lipid Droplet Formation: Role of Lipid and Glucose Metabolism Monitored by 1H and 13C-Edited 1H MRS in Intact HuT 78 Lymphoblastoid Cells ...... 2890 Egidio Iorio, Claudia Testa, Francesco De Luca, Cinzia Casieri, Emanuela Lococo, Roberto Carnevale, Annarita Stringaro, Maria Condello, Giuseppe Arancia, Luisa Lenti, Luisa Lenti, Roberto Strom, Franca Podo

Tumor Microenvironmental Alterations of Lipid Metabolism Detected by Comparing Cancer Cells with Tumors ...... 2891 Noriko Mori, Kristine Glunde, Tomoyo Takagi, Lin Xiong, Flonne Wides, Zaver Bhujwalla

Imaging the Tumor Macroenvironment: The Effect of Cachectic Tumors on Normal Tissues...... 2892 Marie-France Penet, Samata Kakkad, Paul Winnard, Dmitri Artemov, Zaver M. Bhujwalla

Genomic Expression and Biochemical Characterization of Enzymes Contributing to the Phosphocholine MRS Signal in Ovary Cancer...... 2893 Egidio Iorio, Alessandro Ricci, Maria Elena Pisanu, Luisa Paris, Massimo Di Vito, Paola Alberti, Delia Mezzanzanica, Giancarlo Castellano, Marina Bagnoli, Loris de Cecco, Kristine Glunde, Zaver Bhujwalla, Silvana Canevari, Franca Podo

MRS Observed Effects of Phorbol Myristate Acetate on Lipid Metabolism in DU145 Prostate Tumor Cells ...... 2894 Melissa Suzanne Love, Daniel-Joseph Leung, Theresa Meganne Mawn, Edward James Delikatny

Identification of Lipids in Tissue Extracts of Astrocytic Brain Tumors ...... 2895 Frauke Nehen, Wieland Willker, Rudolf Fahlbusch, Dieter Leibfritz

1H MRS Reveals Altered Lactate Levels in Cancer Cells Subjected to MEK1/2 Signalling Inhibition...... 2896 Maria Falck Miniotis, Paul Workman, Martin O. Leach, Mounia Beloueche-Babari

Cyclooxygenase-2 Silencing of MDA-MB-231 Breast Cancer Cells Reduces Invasion and Alters Metabolism...... 2897 Tariq Shah, Ioannis Stasinopoulos, Flonne Wildes, Zaver M. Bhujwalla

Cellular Glutathione Detected by 1H NMR Can Give Information on Radio- Sensitivity in Tumour Cells in Vitro ...... 2898 Alessandra Palma, Claudio Giovannini, Sveva Grande, Laura Guidoni, Anna Maria Luciani, Antonella Rosi, Orazio Sapora, Vincenza Viti

The Nucleotide Sugar UDP-GlcNAc, a Major Glycosylation Precursor, Can Be Observed in Intact Tumour Cells by 1H NMR in the Low Field Spectral Region...... 2899 Antonella Rosi, Alessandra Palma, Sveva Grande, Laura Guidoni, Anna Maria Luciani, Vincenza Viti

Metabolic Characterization of an Imatinib-Resistant Chronic Myelogenous Leukemia Cell Model...... 2900 Brian James Dewar, Kayvan Keshari, Rex Errol Jeffries, Lee M. Graves, Jeffrey M. Macdonald

Effect of Androgens on Intracellular Polyamine Levels in Androgen-Dependent and Androgen-Independent Prostate Cancer Cell Lines ...... 2901 Nicholas G. Spencer, Eszter Nagy, Nandita M. DeSouza, Geoffrey S. Payne

Tissue Metabolic Concentrations Investigated with Respect to Prognosis for Breast Cancer Patients ...... 2902 Beathe Sitter, Tone Frost Bathen, Hans Fjøsne, Jostein Halgunset, Steinar Lundgren, Ingrid Susann Gribbestad

Investigation of Features Related to Androgen Dependency in Prostate Cells Using 1H HRMAS MRS and Principal Component Analysis...... 2903 Robert Leslie Davidson, Nick Spencer, Simon J. Doran, Nandita M. deSouza, Geoffrey S. Payne

Choline Metabolic Composition Correlates to Basal-Like and Luminal a Genetic Subtypes in Orthotopic Breast Cancer Xenografts...... 2904 Siver Andreas Moestue, Else Marie Huuse, Olav Engebråten, Beathe Sitter, Gunhild Mari Mælandsmo, Tone Frost Bathen, Ingrid Susann Gribbestad

Metabolomic Analysis of Tissue-Serum Pairs for Human Lung Cancer...... 2905 Kate W. Jordan, Christen B. Adkins, Li Su, Eugene J. Mark, David C. Christiani, Leo L. Cheng,

Magnetic Resonance Imaging and Ultrasonography of Chicken Egg Tumor Model...... 2906 Jaak Nairismägi, Ott Rovgeiša, Taavi Päll, Johanna Närväinen, Priit Kogerman

In Vivo Visualization of Mouse Sciatic Nerves Involved with a Pancreatic Cancer Cells Using Manganese Enhanced MR Imaging Technique...... 2907 Hiroaki Mieno, Masayuki Yamaguchi, Shuichi Mitsunaga, Akira Imoto, Tarou Ikumoto, Akira Hirayama, Akira Nabetani, Atsushi Nozaki, Taira Kinoshita, Hirohumi Fujii, Atsushi Ochiai

Diffusion MRI of Choroid Melanoma Tumor in Mouse Eye...... 2908 Peng Sun, Huiying Zhang, Qing Wang, Gregory M. Lanza, Sheng-Kwei Song, Samuel A. Wickline, Junjie Chen

BOLD Changes in the Microenvironment Are an Early Marker of Micrometastatic Breast Cancer in the Rat Brain...... 2909 Matthew D. Budde, E Kay Jordan, Melissa Smith, Eric M. Gold, Joseph A. Frank

BOLD Signal and T2 Responses in Rat F98 and 9L Gliomas to Hypoxic Hypoxia...... 2910 Neil Peter Jerome, Khan Hekmatyar, Risto A. Kauppinen

Apparent Diffusion Coefficient Correlates with Necrosis and Inversely with Proliferation: Histopathological Quantification in a Panel of Human Tumour Xenografts ...... 2911 Jane Halliday, Jose Ulloa, Marietta Scott, Graham Bigley, Herve Barjat, Neil Gray, John C. Waterton, Chris Womack, Carsten Liess

Detection of Colonic Tumorigenesis In Vivo and Monitoring of Local Colonic Tumor Invasion and Metastasis in Mice Using Magnetic Resonance Imaging ...... 2912 Devkumar Mustafi, Urszula Dougherty, Alessandro Fichera, Reba Mustafi, Xiaobing Fan, Gregory S. Karczmar, Marta Zamora, Marc Bissonnette

Chronic Liver Inflammation-Induced Double-Strand DNA Breaks Enhance Hepatocarcinogenesis...... 2913 Hila Barash, Eitan Gross, Natalie Corchia, Irit Cohen, Daniel Goldenberg, Eithan Galun, Rinat Abramovitch

Registration of Complete 3D Histological Tumor Datasets with in Vivo MRI: First Experience...... 2914 Flora Henning, Robert Haase, Sergey Tokalov, Thomas Schulze, Nasreddin Abolmaali

Examining the Source of T2 Components Fit with NNLS...... 2915 Pamela R. Jackson, Roland G. Henry, Tracy Richmond McKnight

In Vivo T2 Measurements of Glioma Growth in Mouse Brain at 9.4T...... 2916 Barbara Blasiak, Boguslaw Tomanek, Tadeusz Foniok, Dave Kirk, Abedelnasser Abulrob, Umar Iqbal, Danica Stanimirovic, Xuequing Lun, Peter Forsyth, Garnette Sutherland

Short T2 Components in the Normal Murine Mammary Gland and Pre-Invasive Carcinoma May Aid in Detection of Early Breast Cancer...... 2917 Sanaz Arkani Jansen, Xiaobing Fan, Erica Markiewicz, Gillian Newstead, Gregory Karczmar

Molecular MR Imaging of Fibrin in Tumors ...... 2918 Ritika Uppal, Zdravka Medarova, Christian Farrar, Guangping Dai, Anna Moore, Peter Caravan

The Ex Vivo and in Vivo MR Study of Glioma Targeted Contrast Agents...... 2919 Barbara Blasiak, Boguslaw Tomanek, Tadeusz Foniok, David Kirk, David Rushforth, Roger MacKenzie, Abedelnasser Abulrob, Umar Iqbal, Danica Stanimirovic, Xuqueng Lung, Peter Forsyth

Synthesis and Characterization of the Tumor Targeting Contrast Agent [Gd (TTDA)] 2- Derivative for MRI...... 2920 Yun-Ming Wang, Ying-Hsiu Lin, Chiao-Yun Chen, Gin-Chung Liu

Synthesis and Characterization CRGD-PEG Iron Oxide Nanoparticles of Noninvasive Imaging for Targeting ανβ3 Integrins by MRI ...... 2921 Yun-Ming Wang, Jen-Yen Lin, Yu-Ting Kao, Gin-Chung Liu

Weighted Combination of Multichannel 1H-MRS Data: Comparison of SNR- And SVD-Based Methods by Simulated, in Vitro and in Vivo Data...... 2922 Alexander Gussew, Jacob Orme, Reinhard Rzanny, Jürgen R. Reichenbach

Implementation of 1H MRS at 3.0 Tesla for the Analysis of the Biochemistry and Function of the Amygdala in Patients with Borderline Personality Disorder and Healthy Controls ...... 2923 Mareen Hoerst, Wolfgang Weber-Fahr, Nuran Tunc-Skarka, Matthias Ruf, Christian Schmahl, Gabriele Ende

Single Voxel Spectroscopy in Different Regions of Human Brain at 7 T...... 2924 Malgorzata Marjanska, Edward J. Auerbach, Pierre-Francois Van de Moortele, Gregor Adriany, Michael Garwood

Cerebral Glutamate Metabolism Via [2-13C] Glucose in Normal Brain...... 2925 Napapon Sailasuta, Kent Harris, Osama Abulseoud, Brian Ross

GABA Detection Via PRESS Constant Echo Time Difference Spectroscopy ...... 2926 Jeff Snyder, Richard B. Thompson, Alan H. Wilman,

Histidine Transport Dynamics Across the Healthy Human Blood-Brain Barrier Investigated by 1H MRS ...... 2927 Daniel Guo Quae Chong, Jean-Marc Nuoffer, Peter Vermathen, Johannes Slotboom, Chris Boesch, Roland Kreis

Simultaneous Two-Channel Mice Brain Chemical Shift Imaging Using a 'standard' Biospec Spectrometer...... 2928 Adrian Rengle, Hélène Ratiney, Sophie Cavassila, Olivier Beuf

MEGA-Edited Detection of Metabolites with Coupled Spin-Systems: Simulations at High Field Strengths...... 2929 Richard A E Edden, He Zhu, Peter B. Barker

Which Pulse Sequence Is Optimal for Myo-Inositol Detection at 3T? ...... 2930 Ileana Hancu

1H-MR Spectroscopy Utilizing a 1T Open MR System: Initial Clinical Results ...... 2931 Thomas G. Perkins, James B. Murdoch, Bryan Goss

Single Echo Time Glutamate Editing at 3 Tesla ...... 2932 Yan Zhang, Stefano Marenco, Jun Shen

Reconstruction of NMR Spectra from Truncated Data with the Fast Pade Transform ...... 2933 Sun Kim, Glen Morrell

Degraded Water Suppression in 1H-MRS Due to Shimming; a Visualisation Method and a Comparison of Shimming Methods...... 2934 Åsa Carlsson, Maria Ljungberg, Göran Starck, Eva Forssell-Aronsson

CSI Without Water Suppression at 3T ...... 2935 Grzegorz Lukasz Chadzynski, Uwe Klose

31P Magnetization Inversion Transfer Study of Three-Site PCr←→ATP←→Pi Exchange System in Human Brain at 7T ...... 2936 Fei Du, Wei Chen

Adiabatic L-COSY at 7T ...... 2937 Saadallah Ramadan, Eva-Maria Ratai, Ovidiu C. Andronesi, A Gregory Sorensen, Carolyn E. Mountford

Cross Peak Enhancement in Constant-Time COSY (CT-COSY)...... 2938 Saadallah Ramadan, Carolyn E. Mountford

Phase-Sensitive Localized COSY (PS-LCOSY) ...... 2939 Saadallah Ramadan, M Albert Thomas

Estimating Saturation Factors for PRESS with Inhomogeneous B1 at 7T...... 2940 Douglas Kelley, Esin Ozturk-Isik, Janine Lupo

Improved 3D PRESS MRSI at 7T Using B1 Field Mapping and Optimization of Transmit Gain...... 2941 Esin Ozturk-Isik, Janine M. Lupo, Sarah J. Nelson, Doug Kelley

Interference of Fluorinated Anesthesia on 19F MRS of Fluorinated Drug Metabolism in Liver...... 2942 Marcela Cortes-Ramirez, Giuseppe Pizzorno, Gopalkrishna Veni, H Michael Gach

Diffusion Measurement of Mobile Lipids Using Co-Resonant Coupled Metabolite Dephasing ...... 2943 Gerd Melkus, Philipp Mörchel, Michael Flentje, Peter Michael Jakob

Dealing with RF in MR Spectroscopy of the Human Breast at 7T...... 2944 Dennis Klomp, Cecilia Possanzini, Bart van de Bank, Vivian Timmers, Alexander Raaijmakers, Vincent Boer, Peter Luijten

Cortical Bone Water Studied with 1H and 2H Double-Quantum Filtered NMR ...... 2945 Henry H. Ong, Felix W. Wehrli

Improving the Spectral Quality of Magnetic Resonance Spectroscopy Using Multi- Taper Methods (MTM)...... 2946 Shang-Yueh Tsai, Stefan Posse, Fa-Hsuan Lin

Phase-Rotation for Spectroscopic Motion Correction...... 2947 Saadallah Ramadan, Eva-Maria Ratai, Ravi Seethamraju, Carolyn E. Mountford

In-Vivo High-Resolution Magic Angle Spinning Proton MR Spectroscopy of Drosophila Melanogaster Flies as a Model System to Investigate Trauma, Innate Immunity and Aging ...... 2948 Valeria Righi, Dionyssios Mintzopoulos, Yiorgos Apidianakis, Ovidiu C. Andronesi, Laurence G. Rahme, A. Aria Tzika

In Vivo 13C MRS of Human Brain at 3T Using Stochastic Decoupling with a Proton Volume Coil ...... 2949 Shizhe Li, Yan Zhang, Shumin Wang, Maria Ferraris Araneta, Christopher Johnson, Robert Innis, Jun Shen

High-Resolution NMR Spectroscopy in Inhomogeneous Fields Via Intermolecular Multiple-Quantum Coherences Between Spin 1/2 and Quadrupolar Nuclei ...... 2950 Zhong Chen, Shuhui Cai, Song Chen

Improved Proton Spectroscopy at 7T Using Localized B1 Calibration ...... 2951 Maarten J. Versluis, Hermien E. Kan, Wouter M. Teeuwisse, Andrew G. Webb

Determination of Residual Dipolar Coupling in Skeletal Muscle of Upper Extremity ...... 2952 John Austin Vargo, Steven L. Lindauer, Raymond R. Raylman, Richard G. Spencer, M. Albert Thomas S. Sendhil Velan

Identification of Urine Biomarkers for X-Ray Radiation in Mice Using NMR Spectroscopy...... 2953 Congju Chen, David J. Brenner, Truman R. Brown

Relationship Between MRS NAA Concentration and DTI ADC Values ...... 2954 Nuran Tunc-Skarka, Wolfgang Weber-Fahr, Mareen Hoerst, Gabriele Ende

Inhibitory Effect of Carbonic Anhydrase Inhibitors on the De Novo Lipogenesis. A Study with 13C-NMR Spectroscopy...... 2955 Abolghasem Mohammadi, Dieter Leibfritz

Tailoring Linear Response Equilibrium Spectroscopy of Cholesterol Esters ...... 2956 Rudolf Fritz Fischer, Sebastian Kozerke, Christof Baltes, Markus Rudin, Peter Boesiger

An Improved Method for Automatic Placement of Spatial Saturation Planes in MR Spectroscopy ...... 2957 Jordan L. Hovdebo, Lawrence Ryner

Automatic Prescription of 3D MRSI with Optimal Coverage and Outer Volume Suppression ...... 2958 Eugene Ozhinsky, Sarah J. Nelson

Subcutaneous Lipid Suppression Via Variable-Density Spiral Sampling for Full Cortical Coverage in Chemical Shift Imaging...... 2959 Joonsung Lee, Borjan Gagoski, Michale Hamm, Elfar Adalsteinsson

INS-PRESS for Functional MRS: Simultaneous With- And Without-Water Suppression Spectral Acquisition on Visual Cortex of Human Brains at 3T...... 2960 Yi-Yu Shih, Chun-Jen Huang, Martin Buechert, Hsiao-Wen Chung, Yi-Jui Liu

Simultaneous Acquisition of Metabolite and Water Signals in Echo Planar Spectroscopic Imaging ...... 2961 Toru Shirai, Satoshi Hirata, Yukari Yamamoto, Yoshitaka Bito

Proton MR Spectroscopy Using Short TE PRESS Without Water Suppression. In Vivo Application to Rat Brain at 7 Tesla ...... 2962 Wolfgang Dreher, Ekkehard Küstermann, Dieter Leibfritz

Clinical Double Quantum Filtered Lactate Spectroscopy of Leg Ischemia and Non- Hodgkins Lymphoma in 3D...... 2963 Eric Albert Mellon, Seung Cheol Lee, Sungheon Kim, Ravinder Reddy, Jerry D. Glickson

High-Resolution NMR Spectra of Heterogeneous Biological Tissues Via Intermolecular Single-Quantum Coherences ...... 2964 Yuqing Huang, Zhong Chen, Shuhui Cai, Jianhui Zhong

Multiple Spin Echo Spectroscopic Imaging of Glutamate and Glutamine (Glx) ...... 2965 Atiyah Yahya, B. Gino Fallone

MR Imaging and Spectroscopy of a Bioartificial Pancreas In Vitro and In Vivo at 11.1 T Using Implantable Probes...... 2966 Nelly A. Volland, Thomas H. Mareci, Nicholas E. Simpson

Mapping Glucose and Lactate Concentrations with Microliter Resolution in Rat Brain Using Short-Echo-Time Spectroscopic Imaging ...... 2967 Vladimir Mlynarik, Cristina Cudalbu, Hanne Frenkel, Rolf Gruetter

Resolution Enhancement of Brain Glutamate, Glutamine and Myo-Inositol by PRESS (TE1, TE2) = (37, 63) Ms at 7T...... 2968 Changho Choi, Ivan Dimitrov, Deborah Douglas, Halima Hawesa

1 T2 Correction and Quantitation Method on Highly Resolved 2D Constant Time H Spectra in Human Brain Using 2D FT of Shared Time Domain Data...... 2969 Hidehiro Watanabe, Nobuhiro Takaya, Fumiyuki Mitsumori

New MR-Scanner Independent B1 Field Mapping Technique ...... 2970 Vaclav Brandejsky, Olof Leinhard Dahlquist, Eva Lund, Peter Lundberg

Ongoing Dual-Angle Measurements for the Correction of Partial Saturation in 31P MR Spectroscopy...... 2971 Orlando Lopez, Damian J. Tyler, Kieran Clarke, Edward Lakatta, Richard G. Spencer

Selectivity Enhancement of Glutamine in Human Brain by Triple Refocusing at 3T: Application to Hippocampus...... 2972 Changho Choi, Carol Tamminga, Ana Stan, Deborah Douglas, Perry Mihalakos, Stephanie Morris

In-Vivo Measurement of Serine in Human Brain by Constant-TE PRESS Difference Editing at 7.0 Tesla ...... 2973 Changho Choi, Ivan Dimitrov, Deborah Douglas

A Systematic Approach for Chemical Quantification in MRSI: Methodological Considerations...... 2974 Neva M. Corrigan, Todd L. Richards, Helen Petropoulos, Seth D. Friedman, Stephen R. Dager

Optimized Detection of Glutamate and Glutamine at 1.5 T, 3 T and 4.7 T...... 2975 Jeff Snyder, Richard B. Thompson, Alan H. Wilman

31P-MR Investigations of Training Effects on Resting State Concentration of Phosphor Metabolites in the M. Gastrocnemius ...... 2976 Reinhard Rzanny, Norbert Stutzig, Alexander Gussew, Werner Alois Kaiser, Hans-Alexander Thorhauer, Jürgen R. Reichenbach

Assessment of Relative and Absolute Quantification Methods in Phosphorus Magnetic Resonance Spectroscopy...... 2977 Jodi E. Miller, Peter C. Williamson, Dick J. Drost

Measurement of Glycine in Human Brain by PRESS at 7.0 Tesla in Vivo...... 2978 Changho Choi, Ivan Dimitrov, Deborah Douglas, Halima Hawesa

MRS 2D Quantification Vs 1D Quantification...... 2979 Tangi Roussel, Hélène Ratiney, Sophie Cavassila

Simultaneous Quantification of g-Aminobutyric Acid, Glutamate, and Glutamine at 3T ...... 2980 Peter Sheffield, Michael D. Noseworthy, John Bienenstock

Proton Metabolite B1–Corrected T1 Mapping in the Human Brain at 3 Tesla...... 2981 Roman Fleysher, Lazar Fleysher, David Hess, Brian Soher, Songtao Liu, Oded Gonen

The Impact of SNR on the Reliability of LCModel and QUEST Quantitation in 1HMRS ...... 2982 Sarah Andrea Wijtenburg, Jack Knight-Scott

Evaluation of Sensitivity and Reliability of Functional MR Spectroscopy Using Virtual Titration...... 2983 Chun-Jen Huang, Yi-Yu Shih, Yi-Jui Liu, Hsiao-Wen Chung

Robust Phase Correction for 1D NMR Spectra: Application to Fully Automated Quantitation of Whole-Body Adiposity in Less Than 5 Seconds...... 2984 Jeffrey Tsao, Brittany Yerby, Yun Jiang

Separation of EMCL and IMCL in Musculoskeletal 1H MR Spectra by Filter- Diagonalization Method (FDM) ...... 2985 Jyh-Miin Lin, Shang-Yueh Tsai

Quantitative 2D In-Vivo Spectroscopy Using the ERETIC Method ...... 2986 Alexander Fuchs, Susanne Heinzer-Schweizer, Anke Henning, Peter Boesiger

Comparision of Metabolite Correlations in 1D and 2D Quantitative Spectroscopy...... 2987 Alexander Fuchs, Anke Henning, Thomas Lange, Peter Boesiger

Outer-Volume Suppression Pulses to Improve In-Vivo 2D MR Spectroscopy ...... 2988 Roland Kreis, Daniel Guo Quae Chong

13 Metabolism of Hyperpolarized 1, 4- C2-Fumarate in Human Cancer Cell Lines...... 2989 Anna Gisselsson, Magnus Kalsson, Pernille Rose Jensen, René in 't Zandt, Georg Hansson, Mathilde H. Lerche

Using Spectral-Spatial Saturation RF Pulses to Remove Blood Signals in Hyperpolarized Carbon-13 Metabolic Studies...... 2990 Kevin Kai-Chi Leung, Albert P. Chen, Angus Z. Lau, Wilfred W. Lam, Charles H. Cunningham

Hyperpolarized 13C 3D Metabolic Imaging with Stimulated Echoes for Flow Suppression...... 2991 Peder E. Z. Larson, Ralph Hurd, Adam B. Kerr, Robert Bok, John Kurhanewicz, Daniel B. Vigneron

Improved Resolution of 2D and 3D [1-13C] Hyperpolarized MRSI Using a 3- Element Coil and SENSE Reconstruction ...... 2992 Janine M. Lupo, Peder E. Larson, Albert P. Chen, James Tropp, Esin Ozturk-Isik, Daniel B. Vigneron, Ralph Hurd, Sarah J. Nelson

Hyperpolarzed 13C-1-Pyruvate Metabolic Imaging of Inflammatory Arthritis ...... 2993 John Dewolfe MacKenzie, Dirk Mayer, Yi-Fen Yen, Shreyas Vasanawala, James Tropp, Daniel M. Spielman

14 Substrates Are "Ready-To-Go" for in Vivo DNP Hyperpolarization Studies ...... 2994 Magnus Karlsson, Pernille Rose Jensen, Anna Gisselsson, Rene in 't Zandt, Georg Hansson, Mathilde Hauge Lerche

Volume 6

In Vivo Hyperpolarized 13C-MRS of Ethanol-Modulated Pyruvate Metabolism in the Rat...... 2995 Daniel M. Spielman, Dirk Mayer, Yi-Fen Yen, James Tropp, Ralph E. Hurd, Adolf Pfefferbaum

Hyperpolarized 13C MRS in the Rat Brain: Spectral Improvements with 1H Decoupling...... 2996 Malgorzata Marjanska, Dinesh K. Deelchand, Isabelle Iltis, Pierre-Gilles Henry

Simultaneous Multicompound Hyperpolarization by DNP...... 2997 Kayvan Keshari, David Wilson, Mark VanCriekinge, Daniel Vigneron, Jeffrey Macdonald, John Kurhnaewicz

Probing the In Vivo Compartmentalization of Hyperpolarized Pyruvate Using Gadodiamide Induced T1 Relaxation...... 2998 Eric T. Peterson, Jeremy W. Gordon, Krishna N. Kurpad, Sean B. Fain, Ian J. Rowland

Imaging Fluoropyrimidine-Based Cancer Chemotherapy Using 13C Hyperpolarised MR Technology ...... 2999 Yann Jamin, Simon P. Robinson, Martin O. Leach, Thomas R. Eykyn

13C MRI Reporter Probe System with Dynamic Nuclear Polarization ...... 3000 Albert P. Chen, Ralph E. Hurd, David M. Wilson, Graham Wright, Charles H. Cunningham

Non-Invasive Detection of Cell Death in MCF-7 Breast Cancer Cells by Hyperpolarized 13C MRS ...... 3001 Timothy H. Witney, Roberta Napolitano, Mikko I. Kettunen, Ferdia A. Gallagher, Kevin M. Brindle

Hyperpolarized 13C MRS Detection of Reduced Pyruvate-Lactate Conversion Following PI3K Inhibition...... 3002 Christopher S. Ward, Humsa Venkatesh, Alissa Brandes, Mark van Criekinge, Hagit Dafni, John Kurhanewicz, C. David James, Daphne A. Haas-Kogan, Sabrina M. Ronen

Spin Tagging in Hyperpolarzied Carbon-13 Metabolic Studies ...... 3003 Charles H. Cunningham, Albert P. Chen, Ralph E. Hurd

Radiation Damping Observed in Hyperpolarized 13C-1-Pyruvate at 14.1 T...... 3004 Mark VanCriekinge, Albert Chen, Dan Vigneron, James Tropp

Multi-Coil Metabolic Imaging, with SENSE Reconstruction, of Hyperpolarized [1-13C] Pyruvate in a Live Rat at 3.0 T...... 3005 James Tropp, Albert Chen, Janine Lupo, Paul Calderon, Thomas Grafendorfer, Don McCune, Fraser Robb, Yi-Fen Yen, Peder Larson, Robert Bok, Simon Hu, Rolf Schulte, Dan Vigneron, Ralph Hurd, Sarah Nelson

Comparison of HMQC and Dynamic Nuclear Polarization for Detection of 13C Tracers in the Perfused Mouse Heart ...... 3006 Crystal Harrison, A Dean Sherry, Craig R. Malloy, Matthew E. Merritt,

On the Perfomance of RARE, TRAPS and BSSFP in Imaging of Hyperpolarized Compounds ...... 3007 Jochen Leupold

13 Effect of Albumin on Longitudinal Relaxation of [1- C1]-Pyruvate...... 3008 Karlos X. Moreno, Scott Sabelhaus, Craig R. Malloy, A Dean Sherry, Matthew E. Merritt

Secondary Substrate Assisted Dynamic Nuclear Polarization ...... 3009 Albert P. Chen, Charles H. Cunningham, David M. Wilson, Susan J. Kohler, John Kurhanewicz, Daniel B. Vigneron, Ralph E. Hurd

Localized Spectroscopy in the Rat Brain Following Hyperpolarized [2-13C] pyruvate Injection ...... 3010 Isabelle Iltis, Dinesh Kumar Deelchand, Christopher Nelson, Pierre-Gilles Henry, Malgorzata Marjanska

Imaging Carbonic Anhydrase Activity Using Hyperpolarized 13C-Labeled Bicarbonate...... 3011 Ferdia Aidan Gallagher, Mikko I. Kettunen, Rebekah L. McLaughlin, De-en Hu, Tim H. Witney, Jan H. Ardenkjaer-Larsen, Kevin M. Brindle

Examination of Mouse Mammary Tumor Cell Metabolism with Hyperpolarized [1-13C] Pyruvate in the Presnce and Absence of Glutamine...... 3012 Anthon Mancuso, Stephen Kadlecek, Robert V. Cadman, Matthew A. Stetz, Roland Knoblauch, Craig B. Thompson, Rahim Rizi

Kinetic Modeling of Hyperpolaized [1-13C]Pyruvate Metabolism in Blood...... 3013 Kevin Kai-Chi Leung, Wilfred W. Lam, Albert P. Chen, Charles H. Cunningham

Efficient Hyperpolarised 13C Metabolic Imaging with Rosette Spectroscopic Imaging ...... 3014 Rolf F. Schulte, Florian Wiesinger, Kenneth M. Fish, David Whitt, Ileana Hancu

Hyperpolarized 13C MRS in the Rat Brain: Spatial Origin of Signals ...... 3015 Malgorzata Marjanska, Isabelle Iltis, Dinesh K. Deelchand, Michael Garwood, Pierre-Gilles Henry

Feasibility of SNR Enhancement in Flyback Echo Planar Spectroscopic Imaging Through Parallel Imaging with Application to Hyperpolarized 13C Metabolic Imaging...... 3016 Cornelius von Morze, Peder EZ Larson, Simon Hu, Adam B. Kerr, Michael Lustig, James Tropp, John M. Pauly, Daniel B. Vigneron

Autotriggering for DNP-Polarized In-Vivo 13C Experiments...... 3017 Venkat Ramanan, Albert Pofu Chen, Graham A. Wright, Charles H. Cunningham

Measuring Glutamate Metabolism in Vivo in Tumors Using Dynamic Nuclear Polarization ...... 3018 Ferdia Aidan Gallagher, Mikko I. Kettunen, De-en Hu, Sam E. Day, Magnus Karlsson, Anna Gisselsson, Mathilde H. Lerche, Kevin M. Brindle

A Large Volume Multi-Samples DNP Polarizer Dedicated to MR Biomedical Applications...... 3019 Florent Goutailler, Bruno Montcel, Gérard Vermeulen, Dominique Grand, Pierre-Etienne Wolf, Yannick Cremillieux

13C- & 31P-Hyperpolarized Intermediates of Glucolysis and Gluconeogenesis: Phosphoenolpyruvate...... 3020 Joachim Bargon, Rahim R. Rizi

Validation of an Efficient and Compact Para-Hydrogen Catalytic Converter System for PHIP Studies ...... 3021 Ayelet Gamliel, Hyla Allouche-Arnon, Ruppen Nalbandian, Elena Vinogradov, Aaron K. Grant, Robert E. Lenkinski, Claudia M. Barzilay, J. M. Gomori, Rachel Katz-Brull

Hyperpolarization Storage at Different Magnetic Field on Perdeuterated Parahydrogenated Molecules for MRI Application ...... 3022 Francesca Reineri, Daniela Santelia, Roberto Gobetto, Silvio Aime

Effects of Deuteration on 13C Relaxation Times in Neuro-Metabolic Compounds: Implications for Hyperpolarized Spectroscopic Imaging ...... 3023 Hyla Allouche-Arnon, Ayelet Gamliel, Ruppen Nalbandian, Mor Mishkovsky, Lucio Frydman, J. Moshe Gomori, Robert E. Lenkinski, Claudia M. Barzilay, Rachel Katz-Brull

In Vivo Hyperpolarized Lipophilic Agents Targeting Atherosclerotic Plaque ...... 3024 Eduard Y. Chekmenev, Henry Chan, Shawn R. Wagner, Wanda F. Reynolds, Brian D. Ross, Pratip Bhattacharya

Cancer Imaging with Succinate Hyperpolarization ...... 3025 Pratip Bhattacharya, Eduard Y. Chekmenev, Shawn Wagner, Henry R. Chan, William H. Perman, Alan Epstein, Brian D. Ross

Flip Angle Calibration Using SPAMM for Hyperpolarized 3He MRI...... 3026 Julien Rivoire, Maxim Terekhov, Elena Knaub, Florian M. Meise, Sergei Karpuk, Wolfgang G. Schreiber

Increased Volumetric Activity for Hyperpolarized DNP Solutions...... 3027 Eric T. Peterson, Matthew G. Erickson, Sean B. Fain, Ian J. Rowland

Real Time Liquid State Polarization Measurements for in Vivo Exams Using Hyperpolarized 13C Compounds...... 3028 Ileana Hancu, Randy Giaquinto, Robert Lenkinski, W Thomas Dixon

No Clinical Toxicity Is Seen in Vivo from Hyperpolarized PASADENA MR Reagents or Catalyst...... 3029 Henry R. Chan, Pratip Bhattacharya, Ashraf Imam, Anna Freundlich, Thao Tran, William H.Perman, Alexander P. Lin, Kent Harris, Eduard Y. Chekmenev, Marylou Ingram, Brian D. Ross

Development of a Fast Field-Cycling Method for Polarizing C13 Using Parahydrogen-Induced Polarization...... 3030 Aaron K. Grant, Elena Vinogradov

Hyperpolarized 1H NMR Employing Low Gamma Nucleus as a Spin Order Storage...... 3031 Eduard Y. Chekmenev, Valerie A. Norton, Pratip Bhattacharya, Brian D. Ross, Daniel P. Weitekamp

Hyperpolarized 15N MR: PASADE15NA & D15NP...... 3032 Pratip Bhattacharya, Shawn Wagner, Henry R. Chan, Eduard Y. Chekmenev, William H. Perman, Brian D. Ross

Towards Receptor Targeted 13C Hyperpolarized MR Contrast Agents...... 3033 Eduard Y. Chekmenev, Siu-Kei Chow, Jan B. Hoevener, Valerie A. Norton, Kent C. Harris, Thao T. Tran, William H. Perman, Daniel P. Weitekamp, Brian D. Ross, Pratip Bhattacharya

Parahydrogen Induced Polarization of Barbituric Acid Derivatives. 13C Hyperpolarization Studies ...... 3034 Meike Roth, Kerstin Münnemann, Joachim Bargon, Hans Wolfgang Spiess, Achim Koch

13C NMR Signal Enhancement by Using Parahydrogen Induced Polarization (PHIP) and Appropriate Pulse Sequences...... 3035 Meike Roth, Joachim Bargon, Hans Wolfgang Spiess, Achim Koch, Kerstin Münnemann

Obstacles to Diagnostic PASADENA Hyperpolarization in Humans ...... 3036 Thao T. Tran, Henry R. Chan, Johnathan Chou, Shawn Wagner, Pratip Bhattacharya, Brian D. Ross,

Continuous Flow Dynamic Nuclear Polarization of Water Under Ambient Conditions for in-Vivo Perfusion MRI ...... 3037 Mark D. Lingwood, Samuel T. Tokuyama, Elliott R. Brown, Songi Han

Dynamic Nuclear Polarization of Silicon-Based Nanoparticle Magnetic Resonance Imaging Agents ...... 3038 Maja Clare Cassidy, Jacob W. Aptekar, Menyoung Lee, Ronald L. Walsworth, Charles M. Marcus

Long-T1 Silicon Nanoparticles for Hyperpolarized Magnetic Resonance Imaging ...... 3039 Maja Clare Cassidy, Jacob Webster Aptekar, Alexander C. Johnson, Robert A. Barton, Menyoung Lee, Chinh Vo, Alison L. Hill, Ross Webster Mair, Matthew S. Rosen, Ronald L. Walsworth, Charles M. Marcus

Simultaneous Imaging of Tumor Oxygenation and Microvascular Permeability Using Hyperpolarized 1H-MRI in Mice...... 3040 Shingo Matsumoto, Sonny Batra, Hironobu Yasui, Sankaran Subramanian, Nallathamby Devasahayam, Jeeva P. Munasinghe, James B. Mitchell, Murali C. Krishna

19F-MRI Using Hyperpolarized Substrates Generated Via Parahydrogen-Transfer ...... 3041 Ute Bommerich, Samir Mulla-Osman, Joachim Bargon, Johannes Bernarding

Measurement of Hyperpolarized 15N-Choline Using Polarization Transfer with 1H Detection ...... 3042 Vladimir Denisov, Arnaud Comment, Paul Vasos, Sami Jannin, Jacques van der Klink, Riddhiman Sarkar, Geoffrey Bodenhausen, Helene Hall, Deniz Kirik

Sub-Micromolar Concentrations of Contrast Agent Have a Quantifiable Influence on the Hyperpolarized Lithium- 6 Relaxation Time in Vivo ...... 3043 Ruud Bernardus van Heeswijk, Fiodar Kurdzesau, Cristina Cudalbu, Arnaud Comment, Jacques J. van der Klink, Gil Navon, Rolf Gruetter

Optimal Choice of Pulse Phases in Triple-Quantum Filtered Sodium Imaging in the Presence of B0 Inhomogeneities ...... 3044 Christian Matthies, Armin M. Nagel, Lothar R. Schad, Peter Bachert

Evaluation of Lung Tumor Oxygenation Using FREDOM and TOLD ...... 3045 Jesus Pacheco-Torres, Dawen Zhao, Debu Saha, Pilar Lopez-Larrubia, Sebastian Cerdan, Ralph P. Mason

Parameter Optimization for 7T 23Na-MRI ...... 3046 Armin Michael Nagel, Sebastian Schmitter, Michael Bock, Ewald Moser, Wolfhard Semmler, Lothar Rudi Schad

Sodium ‘Invisibility’ in Single Quantum Sodium Imaging of the Human Brain...... 3047 Rob Stobbe, Christian Beaulieu

Fluorine-19 Based MR Imaging Tracer 19FIT for Drug Dilvery Research ...... 3048 Xin Liu, Zhong-Xing Jiang, Yihua Bruce Yu, Eun-Kee Jeong

23Na SPRITE in Vivo Human Brain Tumour Imaging...... 3049 Joachim B. Kaffanke, Sandro B. Romanzetti, N. Jon Shah,

Imaging an Inflammatory Response in a Sponge Granuloma Model Using 19F-MRI...... 3050 Vinod Kaimal, Tracey Monterosso, Michael Woolliscroft, Joseph Cornicelli, Robbie B. Mailliard, Eric T. Ahrens, Aaron D. Nelson, Cameron Barnard, James Mobley, Patrick McConville

Quantitative Sodium MRI of the Mouse Prostate ...... 3051 Jamie Near, Robert Bartha,

A Triple-Resonant RF Coil Setup for 1H, 23Na and 39K MR Imaging of the Rat Brain at 9.4T ...... 3052 Mark Aurel Augath, Patrick Heiler, Stefan Kirsch, Lothar R. Schad

Improved Quantitative Sodium Imaging with a Flexible Twisted Projection Design and B0 Inhomogeneity Correction...... 3053 Aiming Lu, Frederick C. Damen, Ian C. Atkinson, Theodore Claiborne, Keith R. Thulborn

Measurement of Post-Exercise Phosphocreatine Recovery Kinetics in Muscle Using 31P RARE MRI...... 3054 Robert L. Greenman, Howard A. Smithline

Rapid EPR Oximetry Using Sparse Spin Distribution...... 3055 Subhojit Som, Lee C. Potter, Rizwan Ahmad, Deepti S. Vikram, Periannan Kuppusamy

Experimental Setup for DNP Spectroscopy and Variable Field Proton Electron Double Resonance Imaging ...... 3056 Alexandre Samouilov, Eric Kesserling, Sergey Petryakov, Keerthi Shet, Ziqi Sun, David J. Lurie, Jay L. Zweier

Influence of Paramagnetic Changes in Cytochrome c on T2-Weighted MRI of G93A-SOD1 Transgenic ALS Mice ...... 3057 Karunakaran Chandran, Xiping Liu, Donna McAllister, Vinai Roopchansingh, B. Douglas Ward, William E. Antholine, Joy Joseph, Shi-Jiang Li, B. Kalyanaraman

Development of Fast CW-EPR Imaging ...... 3058 Hideo Sato-Akaba, Hirotada Fujii, Hiroshi Hirata

Simultaneous EPR 3D Image Reconstruction and Visualization During Acquisition of Projection Data ...... 3059 Hideo Sato-Akaba, Hiroshi Hirata

In Vivo Electron Paramagnetic Resonance Detects Oxidative Stress in Skeletal Muscle After Burn Trauma...... 3060 Nadeem Khan, Sriram P. Mupparaju, Dionyssios Mintzopoulos, Meenu Kesarwani, Valeria Righi, Laurence G. Rahme, Harold M. Swartz, A Aria Tzika

Resonator for Co-Registration EPR/NMR Imaging and Spectroscopy ...... 3061 Sergey V. Petryakov, Alexandre Samoulilov, Eric Kesselring, Jay L. Zweier

Variation of the Overhauser Enhancement with Field-Cycling...... 3062 David J. Lurie, Keerthi Shet, George L. Caia, Eric Kesselring, Sergey Petryakov, Alexandre Samouilov, Jay L. Zweier

µMRI Optimisation for Phenotyping the Embryo Mouse Heart ...... 3063 Jon Orlando Cleary, Anthony Nathan Price, David L. Thomas, Peter J. Scambler, Vanessa Kyriakopoulou, Roger J. Ordidge, Mark Francis Lythgoe

Quantitative MR Microscopy of the Liver and Kidneys in a Mouse Model of Polycystic Kidney Disease (PKD)...... 3064 Choong-Heon Lee, Jeremy J. Flint, Lisa Guay-Woodford, Stephen J. Blackband

Extend Your Conventional Animal MRI to a Microimaging System...... 3065 Hans Weber, Dominik Paul, Jürgen Hennig, Dominik von Elverfeldt

MR Investigation of a Teratogen-Mediated Mouse Model of Cleft Lip Palate ...... 3066 Robert J. Lipinski, Wade Bushman, Ian J. Rowland

Achieving Equilibrium in Active Staining for MRI of Fixed Mouse Brain ...... 3067 Michael David Wong, Sharon Portnoy, Christine Laliberté, R Mark Henkelman

Compressed Sensing for Multiple Mouse Whole Body MRI...... 3068 Jonathan Bishop, R Mark Henkelman

Monitoring Degradation of Implantable Drug Delivery Devices Using MR Relaxation & Diffusion Imaging ...... 3069 Josh M. Bray, Mark Filiaggi, Chris V. Bowen, Steven D. Beyea

Feasibility of Arterial Input Functions from Phase Data in T1-Weighted Dynamic Contrast-Enhanced MRI...... 3070 Anders Garpebring, Nils Östlund, Mikael Karlsson

Quantification of Blood Volume and Transvascular Water Exchange Using Gd- DTPA in Mouse Brain...... 3071 Young Ro Kim, Guangping Dai, Shuning Huang, Peter Caravan, Alexei Bogdanov, Bruce Ro Rosen

Comparison of Transvascular Water Exchange Between Mannitol and CO2 Challenges...... 3072 Shuning Huang, Guangping Dai, Alexei Bogdano, Bruce R. Rosen, Young Ro Kim

Comparison of Baseline Cerebrovascular Changes Between ENOS Knockout and Wild Type Mice...... 3073 Shuning Huang, Dmitriy Atochin, Guangping Dai, Alexei Bogdano, Paul L. Huang, Bruce R. Rosen, Young Ro Kim

1 Brain Capillary Water Permeability from Proton Density H2O Imaging in the Rat During Deuterated Saline Bolus Passage ...... 3074 Audrey H. Selzer, William D. Rooney, Thomas M. Barbara, James A. Goodman, Charles S. Springer Jr. , Xin Li

The Effects of Parameter Assignment Variation Using a Reference Region Model on Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI)...... 3075 Mary E. Loveless, Anthony Z. Faranesh, John C. Gore, Thomas E. Yankeelov

Relative Recirculation Abnormalities in Collapsed Lung: A Metric for Vascular Tortuosity?...... 3076 Christopher K. Macgowan, Shengping Wu, Rogerio Tessler, Jaques Belik, Andrea Kassner

About the Limitations of the PS-Limited Tofts Model...... 3077 Guido Correia Carreira, Dirk Beyersdorff, Lutz Luedemann

Model Selection in High Temporal Resolution DCE-MRI of Breast Tumors...... 3078 Robert Luypaert, Smitha Makkat, Johan De Mey, Steven Sourbron

Assessement of Blood Volume Fraction Using MRI: Characterization in Silico of Possible Bias...... 3079 Thomas Christen, Nicolas Joudiou, Nicolas Pannetier, Sebastien Reyt, Christoph Segebarth, Chantal Rémy, Emmanuel L. Barbier

Multifrequency MR Elastography on Human Thigh Muscle in Relaxation and in Contraction...... 3080 Dieter Klatt, Uwe Hamhaber, Sebastian Papazoglou, Katrin Rettig, Hasan Nuzha, Juergen Braun, Ingolf Sack

In-Vivo Brain Viscoelastic Anisotropic Properties Using DTI and MR-Elastography ...... 3081 Michael A. Green, Lynne E. Bilston, Elijah Van Houten, Ralph Sinkus

Magnetic Resonance Elastography in Bounded Media...... 3082 Arunark Kolipaka, Kiaran P. McGee, Armando Manduca, Kevin J. Glaser, Philip A. Araoz, Richard L. Ehman

A Dual-Stage Reconstruction Algorithm for Magnetic Resonance Elastography ...... 3083 Elijah Evenstar Wallace Van Houten, Ralph Sinkus

In Vivo MR Elastography of Liver: Comparison to Oscillatory Rheometer Studies of Tissue Specimen ...... 3084 Dieter Klatt, Christian Friedrich, Asbach Patrick, Hasan Nuzha, Katrin Rettig, Sebastian Papazoglou, Uwe Hamhaber, Juergen Braun, Ingolf Sack

MR Elastography at 7T to Measure Tissue Biomechanical Properties for Improved Registration of Histopathology and Radiation Therapy Images...... 3085 Deirdre Maria McGrath, Warren D. Foltz, Carolyn J. Niu, Joanne L. Moseley, Adil Al-Mayah, Kristy K. Brock

Viscoelastic Shear Properties of the Cerebellum and Cerebrum Measured by MRElastography ...... 3086 Michael A. Green, Lynne E. Bilston, Elijah Van Houten, Ralph Sinkus

Inversion Algorithm by Integral Type Reconstruction Formula for Magnetic Resonance Elastography...... 3087 Mikio Suga, Hisayuki Miura, Hiroshi Fujiwara, Takao Yamamoto, Takashi Tanaka, Qiuming Yu, Ken Arai, Jian Ping Gong, Gen Nakamura, Hiroo Ikehira, Takayuki Obata

Comparison of Brain Viscoelasticity and Brain Volumetry in Healthy Volunteers ...... 3088 Ingolf Sack, Kaspar Streitberger, Uwe Hamhaber, Dieter Klatt, Sebastian Papazoglou, Dagmar Krefting, Jürgen Braun

Assessment of Hepatic Fibrosis in Liver Transplant Patients Using MR Elastography - Preliminary Results ...... 3089 Patrick Asbach, Dieter Klatt, Carsten Kamphues, Peter Neuhaus, Jürgen Braun, Ingolf Sack

Reimbursement for Magnetic Resonance Spectroscopy ...... 3090 Alexander Peter Lin, Verna Clements, Thao Tran, Brian David Ross

A Policy for Management of Incidental Findings in Imaging Research ...... 3091 Melissa M. Jones, Zoltan Patay, Heather M. Conklin, Clinton D. Hermes, Fred H. Laningham, Robert A. Kaufman, Robert J. Ogg fMRI Evaluation of Innovative Implantable Electrode for Peripheral Nerve Stimulation Animal Model ...... 3092 Rupeng Li, Seth Jones, Maida Parkins, Christopher Pawela, Mark Bosbous, Ji-Geng Yan, Hani S. Matloub, James S. Hyde

Nephrogenic Systemic Fibrosis: Incidence Reduction with Screening and Use of Gadobenate Dimeglumine...... 3093 Robert W. Garrett, Andrew L. Wentland, Arjang Djamali, Anna Haemel, Garima Agrawal, Edwin Stanley, Elizabeth A. Sadowski

Changes in Properties of Polyvinyl Alcohol When Prepared Under a Deoxygenated Environment...... 3094 Kyle Wilson, R. Terry Thompson, Gordon Campbell, Gerald Moran

Incidence of Nephrogenic Systemic Fibrosis at Chinese PLA General Hospital...... 3095 Zhitong Zou, Lin Ma, Hengjin Li

MRI Thermometry of Near Field Cumulative Heating Induced by Successive HIFU Ablations ...... 3096 Charles Mougenot, Max O. Köhler, Bruno Quesson, Ari Partanen, Julia Enholm, Chrit T. Moonen, Teuvo Vaara, Gösta J. Ehnholm

Regularized Multicoil MR Thermometry...... 3097 William Allyn Grissom, Viola Rieke, John Pauly, Nathan McDannold, Kim Butts-Pauly

Robust Binary Feedback Control of MR Guided Volumetric HIFU Ablation ...... 3098 Max Oskar Köhler, Julia Enholm, Charles Mougenot, Bruno Quesson, Chrit T. W. Moonen

Monitoring of HIFU Treatment Effectiveness by MR Imaging: An Ex-Vivo Studies with Multi-Spot Heating ...... 3099 En-Li Lin, Hsu-Hsia Peng, Teng-Yi Huang, Yu-Shun Wang, Wen-Shiang Chen, Wen-Yih Isaac Tseng

Fast Volumetric Radiofrequency Current Density Imaging ...... 3100 Kim Shultz, John Pauly, Greig Scott

Proton Resonance Frequency Shift Weighted Imaging for the MR Monitoring of the Thermotherapy ...... 3101 Yi-Lu Tsai, Jyun-Wen Chen, Teng-Yi Huang, Hsu-Hsia Peng, Wen-Shiang Chen, Wen-Yih Isaac Tseng

Rapid FUS Focal Spot Localization Based on MR-ARFI...... 3102 Elena Kaye, Jing Chen, Kim Butts Pauly

Dynamic Susceptibility Induced Asymmetry of MR Proton Resonance Frequency (PRF) Thermometry Maps During Simultaneous RF Ablation Causing Large and Spatially Dependent Temperature Errors...... 3103 Magalie Viallon, Erik Dumont, Joerg Roland, Christoph D. Becker, Sylvain Terraz, Rares Salomir

Image-Guided Modulation of Regional Brain Function Mediated by Focused Ultrasound...... 3104 Seung-Schik Yoo, Alexander Bystritsky, Jong-Hwan Lee, YongZhi Zhang, Krisztina Fischer, Wonhye Lee, Nathan McDannold, Ferenc A. Jolesz

First Human Application of Laser Interstitial Thermal Therapy in GBM Using MR Guided AutoLITT System ...... 3105 Stephen Jones, Gene Barnett, Jeffrey L. Sunshine, Mark Griswold, Andrew Sloan, Micheal D. Phillips, Richard Tyc, Mark Torchia

MRS Thermometry of the Brain Using Calibration Results of Aqueous Metabolite Solutions ...... 3106 Jan Weis, Lucian Covaciu, Sten Rubertsson, Mats Allers, Anders Lunderquist, Francisco Ortiz-Nieto,Håkan Ahlström

Comparison of Thermal Dose Models in Canine Brain Using the Dice Similarity Coefficient ...... 3107 Joshua Yung, Anil Shetty, Adam C. Springer, Jeffrey Weinberg, John D. Hazle, Roger Jason Stafford

MR Temperature Mapping in Brain: A Comparison of the GRE, Segmented EPI and Ss EPI Sequences Based on the Proton-Resonance-Frequency-Method...... 3108 Antje Kickhefel, Joerg Roland, Fritz Schick

Non Invasive Monitoring of the Brain Temperature During Mild Hypothermia...... 3109 Jan Weis, Lucian Covaciu, Sten Rubertsson, Mats Allers, Anders Lunderquist, Håkan Ahlström

MR-Guided Focused Ultrasound Ablation Through the Ribcage ...... 3110 Viola Rieke, Randy Lee King, Aravind Swaminathan, Micheal V. McConnell, Kim Butts Pauly

Visualizing Acute RF Ablation Lesions in the Heart Using Non-Contrast MRI at 3T...... 3111 Sathya Vijayakumar, Eugene G. Kholmovski, Rob S. MacLeod, Josh Blauer, Jayne Davis, J. Rock Hadley, Edward DiBella, Kamal Vij, Dennis L. Parker, Nassir F. Marrouche

Registration and Visualization of Left Atrial Scar Due to Pulmonary Vein Ablation with Recorded Ablation Sites...... 3112 Jason E. Taclas, John V. Wylie, Reza Nezafat, Thomas H. Hauser, Mark E. Josephson, Jeff M. Hsing,Warren J. Manning, Dana C. Peters

Heating of Fat Leads to Significant Temperature Errors in PRFS Based MR Thermometry...... 3113 Sara Maria Sprinkhuizen, Maurits K. Konings, Chris J. Bakker, Lambertus Wilhelmus Bartels

Temperature Dependence of Relaxation Times in Individual Fatty Acid Components and Its Consideration for MR Thermometry of Adipose Tissues...... 3114 Kagayaki Kuroda, Makoto Obara, Marc Van Cauteren, Masatoshi Honda, Yutaka Imai

Breast Temperature Mapping Using Model-Based PRFS Method ...... 3115 Xinyi Pan, Cheng Li, Kui Ying, Dehe Weng, Wen Qin, Kuncheng Li

Three Dimensional Targeting for Liver MRgFUS Based on Vessel Tree Tracking ...... 3116 Etsuko Kumamoto, Yoshie Takao, Daisuke Kokuryo, Atsuya Okada, Takamichi Murakami, Toshiya Kaihara, Kagayaki Kuroda

A Rapid and Robust Method for Reducing Out-Of-Plane Motion in Dynamic Imaging. Application to MRI Thermometry on Abdominal Organs...... 3117 Thibault Carteret, Mathilde Merle, Gregory Maclair, Baudouin denis de Senneville, Chrit Moonen,Bruno Quesson

Real Time Volumetric Temperature Imaging of High Intensity Focused Ultrasound Thermal Ablation on the Liver...... 3118 Bruno Quesson, Christophe Laurent, Gregory Maclair, Charles Mougenot, Baudouin denis de Senneville, Mario Ries, Chrit Moonen

Transcatheter Intraarterial Perfusion (TRIP)-MRI Monitoring of Radiofrequency Ablation in Rabbit VX2 Liver Tumors...... 3119 Dingxin Wang, Kent Sato, Johnathan Chung, Richard Tang, Rachel Klein, Barbara Szolc-Kowalska,Gayle Woloschak, Reed Omary, Andrew Larson

Optimization of Volumetric MR-Guided High-Intensity Focused Ulatrsound Ablations in Moving Organs...... 3120 Silke Hey, Baudouin Denis de Senneville, Gregory Maclair, Max O. Köhler, Bruno Quesson, Chrit T.W. Moonen, Mario Ries

Patient Study of Realtime Magnetic Resonance Temperature Monitoring on Moving Organ Simultaneous to Laserinduced Thermal Therapy (LITT)...... 3121 Antje Kickhefel, Christian Rosenberg, Joerg Roland, Norbert Hosten

Experimental Study of Model-Based PRFS Method on Motion and Field Drift Effects...... 3122 Xinyi Pan, Cheng Li, Kui Ying, Dehe Weng, Wen Qin, Kuncheng Li

Evaluation of Realtime Temperature Monitoring of Human Liver Based on Patients Undergoing a Radiofrequency Ablation...... 3123 Antje Kickhefel, Hansjoerg Rempp, Joerg Roland, Fritz Schick

MRI-Guided Focused Ultrasound (MRgFUS) System for Thermal Ablation of Prostate Cancer: Pre-Clinical Evaluation in Canines ...... 3124 Nathan McDannold, Hadas Ziso, Benny Assif, Arik Hananel, Natalia Vykhodtseva, Peri Gretton, Magdalini Pilatou, Steve Haker, Clare Tempany

Diffusion MRI and Contrast-Enhanced Monitoring of Prostate Microwave Focal Thermal Therapy: An In-Vivo Canine Study...... 3125 Hai-Ling Margaret Cheng, Masoom A. Haider, Marcus J. Dill-Macky, Joan M. Sweet, John Trachtenberg, Mark R. Gertner

Prediction of Long Term Success Rates of MRgFUS for Uterine Fibroids ...... 3126 Yael Inbar, Ronit Machtinger, Dahlia Admon, Boris Khaitovich, Shlomo Cohen-Eilon, Jaron Rabinovici

Preliminary Clinical Experience with a Navigation System for Biopsies in a Diagnostic 1.5T Closed-Bore MR Scanner ...... 3127 Michael Moche, Dirk Zajonz, Tim-Ole Petersen, Jochen Fuchs, Gregor Thörmer, Nikita Garnov, Thomas Kahn, Harald Busse

Are We Ready for Routine Interventional 1.5 Tesla MRI? Experience from 370 MR-Guided Percutaneous Interventions ...... 3128 Martin Deli, Markus Braun, Serban Mateiescu, Jan Becker, Yvonne Maratos, Martin H J Busch, Dietrich H W Grönemeyer

Immobilization of Breast Tissue Using Small Beads for MR-Guided Breast Interventions...... 3129 Matthew Smith, Catherine Moran, Xu Zhai, Ray Harter, Frederick Kelcz, Sean Fain

MRI Guided Robotic Assisted Pain Therapy ...... 3130 Andreas Melzer

Clinical Use of an Image-Guided Remote Manipulator for Endorectal Prostate Biopsy...... 3131 Marc A. Rea, Zion Tse, Veronica Morgan, Sharon Giles, Donald W. McRobbie, Michael Lamperth,Ian Young, Nandita deSouza

Punctures in a Hybrid MR/X-Ray-Angiographysuite Using MR Image Overlay and Stereoscopic X-Ray Navigation: A Study in Phantoms, Animals and a Patient ...... 3132 Bernhard Meyer, Dara L. Kraitchman, Alexander Brost, Liron Yatziv, Norbert Strobel, Wesley Gilson,Jonathan S. Lewin, Frank K. Wacker

X-Ray Fused with Magnetic Resonance (XFM) Applied to Image-Guided Embolization of Venous Malformation in an XMR Suite...... 3133 Dany Simard, Sylvain Deschenes, Josee Dubois, Gilles Soulez, Gilles Beaudoin

Biopsy of Liver Lesions with MR Fluoroscopy Using an High Field Open MRI Scanner...... 3134 Frank Fischbach, Juergen Bunke, Markus Thormann, Gunnar Gaffke, Jungnickel Kerstin, Jens Ricke

Real-Time MR-Guided Percutaneous Interventions in a Dedicated 1.5T Clinical Suite ...... 3135 Sanaz Javadi, Roger Jason Stafford, Judy U. Ahrar, Sanjay Gupta, Michael J. Wallace, Li Pan,Kamran Ahrar

In Vitro and in Vivo Evaluation of MR Fluoroscopy-Guided Injection Therapy for Low Back Pain in Open High- Field MRI ...... 3136 Florian Streitparth, Thula Walter, Jens Rump, Uta Wonneberger, Bernd Hamm, Ulf Teichgräber

Feasibility of Gd-Enhanced Lymph Node MR Imaging for the Integrated MR Endoscope System...... 3137 Yuichiro Matsuoka, Yoshinori Morita, Hayato Yoshinaka, Daisuke Obata, Shoko Fujiwara, Makiya Matsumoto, Etsuko Kumamoto, Hiromu Kutsumi, Kagayaki Kuroda, Takeshi Azuma

Real Time MRI for Guidance of Electrophysiological Interventions Using Carbon Catheters ...... 3138 Peter Nordbeck, Oliver Ritter, Florian Fidler, Marcus Warmuth, Karl-Heinz Hiller, Matthias Nahrendorf, Michelle Maxfield, Sabine Wurtz, Wolfgang Geistert, Peter M. Jakob, Wolfgang R. Bauer

Transcatheter Intraarterial Perfusion (TRIP)-MRI Monitoring of Uterine Fibroid Embolization in VX2 Rabbits ...... 3139 Dingxin Wang, Robert Ryu, Johnathan Chung, Richard Tang, Rachel Klein, Barbara Szolc-Kowalska,Gayle Woloschak, Reed Omary, Andrew Larson

Diffusion-Weighted PROPELLER MRI for Tissue Selective Intra-Procedural Positioning of Percutaneous Biopsy Needles Within Rabbit VX2 Liver Tumors ...... 3140 Jie Deng, Sumeet Virmani, Richard A. Tang, Guang-Yu Yang, Gayle Woloschak, Reed A. Omary,Andrew C. Larson

Towards Fully MR-Guided TACE Procedures: Perfusion MRI and Real-Time MRA Protocols...... 3141 Michael Bock, Ann-Kathrin Homagk, Axel Krafft, Florian Maier, Jessica Schulz, Reiner Umathum,Wolfhard Semmler, Peter Hallscheidt

MR Validation and Quantification of TACE Treatment Through Direct Visualization of Ethiodol with Chemical Shift Based Water-Fat Imaging ...... 3142 Eric M. Bultman, Catherine D. Hines, Walter F. Block, Scott B. Reeder

19F MR-Visualization of Fluoropolymers Using Ultrashort TE Imaging...... 3143 Jürgen Rahmer, Jochen Keupp

In-Vivo Evaluation of an Active Filter System for the ICV Using MRI ...... 3144 Nils A. Kraemer, Erwin Immel, Andreas Melzer, Christina Ocklenburg, Rolf W. Guenther, Gabriele A.Krombach, Elmar Spüntrup

Hybrid Tracking and Visualization of Therapeutic Devices Under MRI Guidance ...... 3145 Orhan Unal, Ethan K. Brodsky, Krishna N. Kurpad

The Interventioal Device Tracking Using Miniaturized Micro Coils...... 3146 Sunil Patil, Jens Anders, Reiner Umathum, Michael Bock, Giovanni Boero, Klaus Scheffler

An Expandable Catheter Loop Coil for Intravascular MRI in Larger Blood Vessels ...... 3147 Ann-Kathrin Homagk, Reiner Umathum, Matthias Korn, Marc-André Weber, Peter Hallscheidt,Wolfhard Semmler, Michael Bock

Comparative Evaluation of the Geometrical Accuracy of Intravascular MRI ...... 3148 Guillaume Gilbert, Gilles Soulez, Gilles Beaudoin

Transmit Power Optimization for Multimode Coil...... 3149 Krishna N. Kurpad, Erik T. Bieging, Ethan K. Brodsky, Orhan Unal

Active Visualization of MR-Compatible Guidewires ...... 3150 Kevan James Thompson Anderson, Graham A. Wright

In-Stent Lumen Visualization Using Intravascular MRI and a BSSFP Sequence...... 3151 Guillaume Gilbert, Gilles Soulez, Gilles Beaudoin

Visualization and Tracking of a Conventional Guidewire with Low Flip Angle SSFP Imaging: An Initial Study ...... 3152 Rohan Dharmakumar, Ioannis Koktzoglou, Sotirios A. Tsaftaris, Sven Zuehlsdorff, Richard A. Tang,Graham A. Wright, Debiao Li

RF Safe Interactive Catheter Traking with Variable DC-Susceptibilty Artefacts ...... 3153 Jens Pinkernelle, Anja Wagner, Jens Rump, Ulf KM Teichgräber

Fast, Robust 3D Visualization and Automatic Slice Repositioning (“Snap-To”) for MR-Guided Interventions Using Active Device “Profiling”...... 3154 Ashvin George, Christina Saikus, John Andrew Derbyshire, Anthony Z. Faranesh, Ozgur Kocaturk, Robert J. Lederman, Michael Guttman, Elliot R. McVeigh

Multi-Phase 3D Angiography Roadmaps for Real-Time MRI-Guided Procedures...... 3155 Haris Saybasili, Anthony Z. Faranesh, Christina E. Saikus, Cengizhan Ozturk, Robert J. Lederman, Michael A. Guttman

Development of a Training Model for PTCD Under MRI Real-Time Guidance (MRI-PTCD) ...... 3156 Ivo Raymond van der Voort, Ioannis S. Papanikolaou, Jens Rump, Christian Seebauer, René Schilling,Sascha Chopra, Bertram Wiedenmann, Ulf Teichgräber, Thomas Rosch

MR-Compatible Wireless Communication System for the Interventional Open High-Field MRI ...... 3157 Felix Victor Guettler, Jens Christian Rump, Ulf Teichgraeber

Reduced Peak Power Dualband VSS Pulse Design ...... 3158 Adam B. Kerr, Peder E. Z. Larson, Daniel B. Vigneron, John M. Pauly

Numerical Optimization of Minimum Phase RF Pulses for UTE Imaging...... 3159 Andrew T. Curtis, Christopher K. Anand, Craig K. Jones, L Martyn Klassen, Ravi S. Menon,

A Novel Radiofrequency Pulse Design for Improving Flip-Angle Uniformity in Ultra-High Field MRI ...... 3160 Jason E. Moore, Marcin Jankiewicz, Huairen Zeng, Adam W. Anderson, Malcolm J. Avison, E Brian Welch, John C. Gore

Compensation of the Susceptibility Artifact in Temporal and Orbitofrontal Region in Brain Using the Flat RF Pulse ...... 3161 Sung Suk Oh, Sungdae Yun, HyunWook Park

Maximizing T2 Signal Weighting Generated by RF Excitation...... 3162 Michael Carl, Mark Bydder, Atsushi Takahashi, Eric Han, Graeme Bydder

Image Contrast Enhancement Using Selective Adiabatic Pulses That Alternate Frequency Sweep Directions ...... 3163 Ziqi Sun, Robert Bartha, Hanna A. Park, Surya Gnyawali

Tailored Saturation Pulses for Abdominal Imaging at 3 Tesla...... 3164 Houchun Harry Hu, Kyunghyun Sung, Krishna S. Nayak

Tailored Shaping and Time Resampling Functions for Inversion Pulses at 7T...... 3165 Aaron Christopher Hurley, Ron Coxon, Ali Al-Radaideh, Uwe Aickelin, Li Bai, Penny Gowland

In Vivo RF Power and SAR Calibration for Multi-Port RF Transmission...... 3166 Yudong Zhu

Effects of Relaxation During RF Pulses on the Homogeneity of Signal Intensity in Parallel Transmission...... 3167 Masaki Sekino, Nicolas Boulant, Michel Luong, Alexis Amadon, Hiroyuki Ohsaki, Denis Le Bihan

Correction of B0 Induced Slice Profile Distortion Using Parallel Transmit ...... 3168 Shaihan J. Malik, David J. Larkman, Jason Filos, Jo V. Hajnal

Compensation of Concomitant Maxwell Gradient Effects in 3D Multi-Element Spatially Selective RF Excitation ...... 3169 Tim Nielsen, Peter Börnert, Ulrich Katscher, Ingmar Graesslin

T2-Compensated Transmit SENSE RF Pulses...... 3170 Martin Haas, Denis Kokorin, Peter Ullmann, Johannes T. Schneider, Jürgen Hennig, Maxim Zaitsev

Time-Optimal VERSE for Multidimensional and Parallel Excitation...... 3171 Daeho Lee, Michael Lustig, William Allyn Grissom, John Mark Pauly

Implementation of VERSE Parallel Transmission at 9.4 T...... 3172 Xiaoping Wu, J. Thomas Vaughan, Kâmil Ugurbil, Pierre-François Van de Moortele

Parallel Transmit Pulse Design Through "Learning" ...... 3173 Yudong Zhu

Minimal-SAR RF Pulse Optimization in Parallel Transmission ...... 3174 Yinan Liu, Jim Ji

Sparse Spokes Pulse Design and B1+ Inhomogeneities in Ultra-High Field MRI ...... 3175 Marcin Jankiewicz, Jason E. Moore, Huairen Zeng, Adam W. Anderson, E. Brian Welch, Malcolm J. Avison, John C. Gore

Fast Selection of Phase Encoding Locations in Parallel Excitation ...... 3176 Daehyun Yoon, Ray Maleh, Anna C. Gilbert, Jeffrey A. Fessler, Douglas C. Noll

Sparse Selective Excitation Pulse Design Using Adaptive Energy Threshold Method...... 3177 Dong Chen, Folkmar Bornemann, Mika W. Vogel, Yudong Zhu

Designing RF Refocusing Pulses for Parallel Transmit Spin Echo Sequences...... 3178 Dan Xu, Kevin F. King

Two Dimensional Spatial Selective Shinnar Le Roux Pulse Design for Arbitrary k-Space Trajectory...... 3179 Yong Pang, Gary Xiong Shen, Xiaoliang Zhang

A Dual Fly-Back Spectral-Spatial RF Pulse for Lipid Suppression and Reduced Susceptibility Artifacts ...... 3180 Weiran Deng, Cungeng Yang, V A. Stenger

SAR Reduction in Parallel Transmission by K-Space Dependent RF Pulse Selection...... 3181 Peter Börnert, Julia Weller, Ingmar Graesslin

Enhanced Image Resolution and Reduced Measurement Time Using Inner Volume Imaging and Parallel Excitation...... 3182 Johannes Thomas Schneider, Martin Haas, J. Hennig, Sven Junge, Wolfgang Ruhm, Peter Ullmann

Single- And Multi-Voxel MR-Spectroscopy Using Parallel Excitation ...... 3183 Peter Ullmann, Johannes Thomas Schneider, Martin Haas, Ralph Wissmann, Wolfgang Ruhm

MR Spectroscopy of Arbitrarily Shaped Single Voxel Using Half-Fourier 2Dselective RF Excitations Based on a PROPELLER Trajectory ...... 3184 Martin Georg Busch, Jürgen Finsterbusch

MR Spectrocopy of Arbitrarily Shaped Single Voxel Using Segmented, Blipped-Planar 2D-Selective RF Excitations with Weighted Averaging...... 3185 Jürgen Finsterbusch, Martin G. Busch

Comparison of Multi-Element RF Coil Designs for 3D Spatially Selective Excitation ...... 3186 Tim Nielsen, Peter Börnert, Ulrich Katscher, Ingmar Graesslin

Robust Large Field-Of-View Water Selective Imaging at 3T with Parallel Transmission ...... 3187 Shaihan J. Malik, David J. Larkman, Jo V. Hajnal

Slab Selective, Regularized RF Shimming...... 3188 Ulrich Katscher, Ingmar Graesslin, Kay Nehrke, Peter Boernert

Considerations for Using Linear Combinations of Array Elements in B1 Mapping...... 3189 Shaihan J. Malik, David J. Larkman, Philip G. Batchelor, Jo V. Hajnal

Estimating K Transmit B1+ Maps from K+1 Scans for Parallel Transmit MRI...... 3190 Amanda Kay Funai, Jeffrey A. Fessler, Douglas C. Noll

Phase-Sensitive B1 Mapping with Adiabatic Excitation...... 3191 Franciszek Hennel, Sascha Köhler, Martin Janich

Optimized Sensitivity for 3D Mapping of the B1 Field Using a Phase-Based Method...... 3192 Davide Santoro, Julien Rivoire, Florian M. Meise, Maxim Terekhov, Wolfgang G. Schreiber

A Novel Method for Simultaneous 3D Mapping of T1, B1 and B0...... 3193 Sha Zhao, Geoffrey J. Parker

Rapid B1 Mapping in the Presence of B0 Variations...... 3194 Sohae Chung, Daniel Kim, Elodie Breton, Leon Axel

In Vivo Mapping of the Peak B1+ Field Strength on a Conventional Scanner ...... 3195 Kyunghyun Sung, Houchun H. Hu, Krishna S. Nayak

Fast B1+ Mapping with a Function Fit Using a Reduced Number of Support Points ...... 3196 Martin Janich, Olaf Dössel, Sascha Köhler, Peter Ullmann

Comparison of EPI and Double Angle B1 Maps at 7T...... 3197 Douglas Kelley, Esin Ozturk-Isik, Janine Lupo

Tailored B1 Mapping for Multi-Element Transmit Applications ...... 3198 Kay Nehrke, Peter Börnert

B1 Mapping and Parallel Excitation Using Vector Decoupling...... 3199 Adam B. Kerr, William A. Grissom, Pascal Stang, Greig C. Scott, John M. Pauly

TROMBONE: T1-Relaxation-Oblivious Mapping of B1...... 3200 Roman Fleysher, Lazar Fleysher, Matilde Inglese, Daniel Sodickson

Improved High-Resolution Magnetic Resonance Imaging Using a Cylindrical Kspace Sampling Method ...... 3201 Ryan Chamberlain, Tom M. Wengenack, Joseph F. Poduslo, Clifford R. Jack, Michael Garwood

Increased SNR in Echo Planar Imaging (EPI) Using a Circular K-Space Coverage ...... 3202 Anders Nordell, Stefan Skare

3D Cones Trajectory with Anisotropic Field-Of-View...... 3203 Mahender K. Makhijani, Krishna S. Nayak

The Shifted Radial Reordering for Intermediate TE Imaging in 3D Long Echo Train Acquisition ...... 3204 Guobin Li, Mathias Nittka, Hans-Peter Hollenbach, Wilhelm Horger, Vladimir Jellus, Stephan Kannengiesser, Berthold Kiefer, Timothy Hughes

Reducing Distortion in EPI Using Partial Fourier Encoding in the Kx-Direction ...... 3205 Samantha J. Holdsworth, Roland Bammer, Stefan Skare

Cartesian Quasi-Random Sampling for Multiple Contrasts and Dynamic Imaging...... 3206 Philipp Ehses, Nicole Seiberlich, Martin Blaimer, Felix Breuer, Wolfgang R. Bauer, Peter M. Jakob

A New Method for Data Acquisition and Image Reconstruction in Parallel Magnetic Resonance Imaging...... 3207 Refaat ElSayed Gabr, Haitham M. Ahmed, AbouBakr M. Youssef, Yasser M. Kadah

Optimization of K-Space Trajectories by Bayesian Experimental Design ...... 3208 Matthias Seeger, Hannes Nickisch, Rolf Pohmann, Bernhard Schölkopf

MR Spectroscopic Imaging Using a Concentric Rings Trajectory...... 3209 Holden H. Wu, Jin Hyung Lee, Dwight G. Nishimura

ZOOM Imaging of the Human Brain at 7T ...... 3210 Christopher J. Wargo, Malcolm J. Avison, E. Brian Welch, John C. Gore

Multiple Gradient- And Spin-Echo EPI Acquisition Technique with Z-Shimming to Compensate for Susceptibility-Induced Off-Resonance Effects ...... 3211 Heiko Schmiedeskamp, Matus Straka, Rexford David Newbould, Stefan Skare, Klaas P. Pruessmann,Roland Bammer

Spin-Echo MRI Using π /2 and π Hyperbolic Secant Pulses...... 3212 Jang-Yeon Park, Michael Garwood

3D PROPELLER-Based Diffusion Weighted Imaging ...... 3213 Eric Aboussouan, Jim Pipe

Single Scan T1 and T2 Mapping Without Flip Angle Correction...... 3214 Philipp Mörchel, Gerd Melkus, Michael Flentje, Peter Michael Jakob

Fast T2 Mapping Using Partially Spoiled Steady State Free Precession (T2-pSSFP)...... 3215 Oliver Bieri, Carl Ganter, Klaus Scheffler

Robust T1 Mapping in the Presence of Partial Volume Effects...... 3216 Vasiliki N. Ikonomidou

In-Vivo Volumetric T1 and T2 Quantitation Using Single Acquisition ...... 3217 Ajit Shankaranarayanan, Eric T. Han

Optimizing Saturation-Recovery Measurements of the Longitudinal Relaxation Rate Under Time Constraints ...... 3218 Jung-Jiin Hsu, Gary H. Glover, Greg Zaharchuk

Automatic High-Order Shimming by Sampling Columns in the Cartesian Coordinates...... 3219 Yan Zhang, Shizhe Li, Jun Shen

Dual Flyback Echo-Planar Imaging for Separation of Water and Fat ...... 3220 Kyunghyun Sung, Brian A. Hargreaves

Faster Fat-Water Imaging with a Novel Multislice Time-Shifted GRASE-Dixon Sequence...... 3221 Kuan J. Lee, Jochen Leupold

Effect of K-Space Sampling Pattern on SNR in Parallel MRI Accelerated IDEAL Sequences ...... 3222 Shawn Joseph Kisch, Philip M. Robson, Catherine DG. Hines, Bryan T. Addeman, Huanzhou Yu, Ann Shimakawa, Ananth Madhuranthakam, Ajit Shankaranarayanan, Jean Brittain, Scott Reeder, Charles McKenzie

Fat Suppression with Slice-Selection Gradient Reversal (SSGR) Revisited...... 3223 Taro Takahara, Jaco Zwanenburg, Fredy Fisser, Tetsuo Ogino, Dennis Klomp, Hans Hoogduin, Jeroen Hendrikse, Thomas Kwee, Willem Mali, Peter Luijten

Fast Fat Suppression Technique for Adaptive 3D Radial MRI Based on Multidimensional Golden Means ...... 3224 Peter Siegler, Rachel Wai-chung Chan, Elizabeth Ramsay, Donald Bruce Plewes

Water-Fat Separation Based on T1 Relaxation Times Using Inversion Recovery bSSFP MR Imaging...... 3225 James W. Goldfarb

Fast-Spin-Echo Imaging and Fat/Water Separation Using a Concentric Rings Trajectory ...... 3226 Holden H. Wu, Jin Hyung Lee, Dwight G. Nishimura

Compressive Chemical-Shift-Based Rapid Fat/Water Imaging...... 3227 Michael Lustig, John Mark Pauly

3D Magnetization-Prepared Imaging and Fat/Water Separation Using a Stack-Of-Rings Trajectory ...... 3228 Holden H. Wu, Jin Hyung Lee, Dwight G. Nishimura

Ultra-Short TR Contrast-Enhanced MR Angiography with Spiral Centric Phase Reordering ...... 3229 Yutaka Natsuaki, Randall Kroeker, Peter Schmitt, Gerhard Laub

Max CAPR: High Temporal and Spatial Resolution 3D CE-MRA with Scan Times Under Five Seconds...... 3230 Clifton R. Haider, John Huston III, Norbert G. Campeau, James F. Glockner, Anthony W. Stanson,Stephen J. Riederer

ToF-SWI: A Dual-Echo Sequence for Simultaneous Time-Of-Flight Angiography and Susceptibility Weighted Imaging ...... 3231 Andreas Deistung, Enrico Dittrich, Jan Sedlacik, Alexander Rauscher, Jürgen R. Reichenbach

Simultaneous Acquisition of High-Resolution T2-Weighted and Cerebro-Spinal-Fluid-Suppressed Images Using Phase-Sensitive Dual-Acquisition Single-Slab Three-Dimensional Turbo Spin Echo Sequence...... 3232 Jaeseok Park, Eung Yeop Kim

Improving Contrast in 3D Structural Brain Imaging at 3T by Incorporating Magnetisation Transfer Pulses Into MDEFT (MT-MDEFT)...... 3233 David L. Thomas, Nikolaus Weiskopf, Roger J. Ordidge

Dual Contrast 3D-TSE, T2w and FLAIR Imaging at 7.0 Tesla ...... 3234 Fredy Visser, Jaco Zwanenburg, Hans Hoogduin, Peter Luijten

3D Double Echo TrueFISP and FLASH Ultra-Short Echo Time Musculoskeletal Imaging...... 3235 Sonia Nielles-Vallespin, Peter Speier, Peter Weale, Saurabh Shah, Edgar Mueller

Balanced Steady-State Feedback Radiation Damping: Balanced SSFR...... 3236 Florian Wiesinger, Eric Fiveland, Christopher Judson Hardy

Free Breathing Cardiac Cine Imaging with Self-Gated Dual-Echo SSFP...... 3237 Daniel A. Herzka, Elliot R. McVeigh, S. Laurence Lee, Peter Kellman, Robert J. Lederman, J. Andrew Derbyshire

First Order Catalyzing of the Non-CPMG Sequence...... 3238 Patrick H. Le Roux

Variable Flip Angle Steady State Free Precession Imaging for Reduction of SAR ...... 3239 Suguru Yokosawa, Yo Taniguchi, Yoshitaka Bito

CAIPIRINHA Accelerated Simultaneous Multi-Slice TrueFISP Real-Time Imaging...... 3240 Daniel Stäb, Marcel Gutberlet, Felix Breuer, Martin Blaimer, Dietbert Hahn, Herbert Köstler

Balanced SSFP Imaging with Variable Tip Angles and Repetition Times ...... 3241 Tolga Çukur, Dwight G. Nishimura

Variable Flip Angle Schedules for Detecting Prepared Longitudinal Magnetization in Snapshot Balanced SSFP ...... 3242 Travis B. Smith, Zungho Zun, Eric Wong, Krishna S. Nayak

Implementation of a 3D Isotropic Ultra-Shot TE (UTE) Sequence...... 3243 Tiejun Zhao, Yongxian Qian, Yik-Kiong Hue, Tamer S. Ibrahim, Fernando Boada

A Modified EPI Sequence for High-Resolution Imaging at Ultra-Short Echo Times ...... 3244 Stefan Hetzer, Toralf Mildner, Harald E. Möller

Minimizing Spiral Image Blurring on Whole-Body 7T Scanner with Multi-Shots and UTE Acquisitions ...... 3245 Yongxian Qian, Tiejun Zhao, Yik-Kiong Hue, Tamer S. Ibrahim, Fernando E. Boada

3-Directional Fast Acceleration Encoding ...... 3246 Felix Staehle, Simon Bauer, Bernd André Jung, Jürgen Hennig, Michael Markl

Methods for Measuring Intercompartmental Exchange: Aqueous Urea as a Model System...... 3247 Richard D. Dortch, Adam R. Horch, Mark D. Does

Small FOV Imaging Using Wavelet Encoding with 2 Dimensional RF Pulses and Gradient Echo...... 3248 Hacene Serrai, Richard Young

Maximizing the Hyperpolarized Signal for a T1 Compensated Variable Angle Acquisition ...... 3249 Shawn Wagner, Pratip Bhattacharya, Brain D. Ross

Toeplitz Random Encoding for Reduced Acquisition Using Compressed Sensing...... 3250 Haifeng Wang, Dong Liang, Kevin F. King, Leslie Ying

Single-Scan Spatially Encoded MRI - Principles & Applications...... 3251 Noam Ben-Eliezer, Yoav Shrot, Lucio Frydman

General Time-Encoding Description and Improved RASER Imaging ...... 3252 Ryan Chamberlain, Michael Garwood

Implementation of SWIFT on a Siemens Clinical Scanner ...... 3253 Julien Valette, Steen Moeller, Djaudat Idiyatullin, Curt Corum, Denis Le Bihan, Michael Garwood, Franck Lethimonnier

Phase Encoding Without Gradients at High Field: TRASE RF MRI at 3T...... 3254 Scott B. King, Peter Latta, Vyacheslav Volotovskyy, Jonathan C. Sharp, Boguslaw Tomanek

Can RF Encoding Improve Parallel Imaging?...... 3255 Rita Gouveia Nunes, Joseph V. Hajnal, David J. Larkman

Analysis of TRASE Echo Train Pulse Sequences for RF Imaging ...... 3256 Jonathan Sharp, Scott B. King, Donghui Yin, Peter Latta, Boguslaw Tomanek

Reference-Free Parallel Imaging with Phase Scrambling (PIPS)...... 3257 Maxim Zaitsev, Jürgen Hennig

Wideband Parallel Imaging...... 3258 Fu-Hsing Wu, Edzer Wu, Li-Wei Kuo, Jyh-Horng Chen, Tzi-Dar Chiueh

Wideband MRI: A New Dimension of MR Image Acceleration ...... 3259 Edzer Lienson Wu, Jyh-Horng Chen, Tzi-Dar Chiueh

3D Isotropic Brain Imaging Using Wideband MRI...... 3260 Edzer Lienson Wu, Tzi-Dar Chiueh, Jyh-Horng Chen,

Reduction of Diffusion Tensor Imaging Acquisition Time with Wideband MR Imaging ...... 3261 Edzer Lienson Wu, Kuan-Hung Cho, Tzi-Dar Chiueh, Jyh-Horng Chen

Noise Analysis for 3-Pt Chemical Shift Based Water-Fat Separation with Accurate Spectral Modeling...... 3262 Venkata Veerendranadh Chebrolu, Huanzhou Yu, Angel R. Pineda, Charles McKenzie, Jean H. Brittain, Scott B. Reeder

IDEAL at 7T in Mice Using Asymmetric Spin Echo and Gradient Echo Acquisitions...... 3263 David H. Johnson, Sreenath P. Narayan, David L. Wilson, Chris A. Flask,

Reduction of Aliasing Artifacts in Diffusion-Weighted PROPELLER Imaging...... 3264 Novena Rangwala, Girish Srinivasan, Xiaohong Joe Zhou

Pulse Sequence Programming Using XML and JavaScript ...... 3265 William Overall, John Pauly

FLUSTER: A Combined Multiecho Radial/Cartesian Encoded Gradient Echo Sequence for Bone and Soft Tissue Segmentation...... 3266 Andre Jan Willem van der Kouwe, Thomas Benner, Michael Hamm, Sonia Nielles-Vallespin, Bruce Fischl

TurboCRAZED BOLD Imaging Detects Specific Activation in the Rat Brain After Somatosensory Stimulation at 16.4 Tesla ...... 3267 David Z. Balla, Hannes M. Wiesner, Gunamony Shajan, Cornelius Faber, Rolf Pohmann

Ultrafast Blood T1 Mapping with Steady-State Free Precession (SSFP) Imaging ...... 3268 Wen-Chau Wu, Jiongjiong Wang

Flip Angle Strategies for Multiphase DENSE ...... 3269 Andreas Sigfridsson, Henrik Haraldsson, Tino Ebbers, Shinichi Takase, Hans Knutsson, Hajime Sakuma

Balanced SSFP Cisternography in the Cerebellopontine (CP) Angle: Inconsistent Vessel Contrast and a Possible Remedy ...... 3270 Pei-Hsin Wu, Chiao-Yuan Lin, Cheng-Chieh Cheng, Hsiao-Wen Chung, Wen-Chau Wu, Brian A.Hargreaves, Norbert J. Pelc

Kt-Accelerated Velocity-Encoded Black-Blood MRI for Quantification of Myocardial Motion at 3.0T...... 3271 Anja Lutz, Axel Bornstedt, Vinzenz Hombach, Robert Manzke, Volker Rasche

Fast Multislice T2-Weighted Image Assessment of Brain with TIDE bSSFP Imaging...... 3272 Yin-Cheng Kris Huang, Chun-Jung Juan, Hing-Chiu Chang, Hua-Shan Liu, Teng-Yi Huang, Hsiao-Wen Chung, Cheng-Yu Chen, Guo-Shu Huang

Multimodal MRI Changes in Cortical Grey Matter Following Formalin Fixation...... 3273 Klaus Schmierer, Janet R. Thavarajah, Harold G. Parkes, David H. Miller, Daniel J. Tozer

Separation of Relaxation Time Constants Through Cylindrical Coordinates ...... 3274 Bahman Tahayori, Leigh Andrea Johnston, Kelvin J. Layton, Peter Mark Farrell, Iven M.Y. Mareels

Effect of RF Pulse Duration on T2 Quantification Using Multi-Echo Spin Echo Sequences ...... 3275 Oliver Bieri, Klaus Scheffler

Bloch Solver Simulation Realization on a Graphics-Processing Unit (GPU) ...... 3276 Silke Maria Lechner, Daniel Butnaru, Hans-Joachim Bungartz, Dong Chen, Mika W. Vogel

“Constant Repetition Time” Imaging Protocols for High Resolution Lung Proton MR Imaging in Mice...... 3277 Magdalena Zurek, Amine Bessaad, Katarzyna Cieslar, Yannick Crémillieux

Analysis of T1 Weighted Spiral Projection Imaging ...... 3278 Ryan Keith Robison, James Grant Pipe

MP2RAGE Contrast Optimization at 7T and Applications...... 3279 José Pedro Marques, Tobias Kober, Gunnar Krueger, Wietske van der Zwaag, Pierre-François van de Moortele, Rolf Gruetter

Elimination of Inflow Enhancement by Partial Pre-Saturation in RF Spoiled Imaging...... 3280 Misung Han, Brian A. Hargreaves

Measuring the Cerebro-Spinal Fluid Temperature Using Diffusion MRI ...... 3281 Zoltan Nagy, Lajos R. Kozak, Marta Bango, Miklos Szabo, Rudas Gabor, Zoltan Vidnyanszki

Increasing Strain Accuracy in Strain-Encoded (SENC) Imaging Using Center-Of-Mass Method ...... 3282 Jakir Hossain, Tamer Basha, Nael F. Osman, Michael A. Jacobs

Dixon bSSFP in the Presence of Bo Inhomogeneities...... 3283 Michel Louis Lauzon, Randall Brooke Stafford, Mohammad Sabati, Richard Frayne

K-Space Point Mapping in the Presence of Inhomogeneous Magnetic Fields for Mobile MR...... 3284 Toni Michael Drießle, Florian Fidler, Michael Ledwig, Stefan Wintzheimer, Daniel Gensler, Peter Michael Jakob

Off-Resonance MRI for Detecting T1 Changes Around Metallic Implants ...... 3285 Wilfred Wing-Kay Lam, Angus Zoen Lau, Charles Henry Cunningham

Comparison of Dixon Methods for Fat Suppression in Single Breath-Hold 3D Gradient-Echo Abdominal MRI ...... 3286 Holger Eggers, Bernhard Brendel, Gwenael Herigault

Iterative Fat-Water Separation in Steady State with Dedicated MRI Systems...... 3287 Luca Balbi, Jochen Leupold, Marco Vicari

Validation of Fat Quantification with T2 Correction and Accurate Spectral Modeling in a Novel Fat-Water-Iron Phantom...... 3288 Catherine DG. Hines, Huanzhou Yu, Ann Shimakawa, Charles A. McKenzie, Venkata V. Chebrolu, Jean H. Brittain, Scott B. Reeder

Influence of Relaxation on Fat Suppression by Dixon Methods in Musculoskeletal MRI...... 3289 Holger Eggers, Peter Boernert, Clemens Bos

Ultra-Low SAR MR Imaging of the Brain at 1.5 Tesla...... 3290 Subhendra Nath Sarkar, Ananth Madhuranthakam, David Alsop, Neil Rofsky, Reed Busse, Rafeeque Bhadelia, Efstathios Papavassiliou, David Hackney

GRAPPA-Accelerated Short Axis BLADE EPI for Multi-Shot Diffusion Weighted Imaging...... 3291 Alto Stemmer, Berthold Kiefer

Comprehensive GRAPPA...... 3292 Jun Miao, Wilbur C. K. Wong, Donglai Huo, David L. Wilson

Quantitative g-Factors for Radial GRAPPA...... 3293 Felix A. Breuer, Nicole Seiberlich, Martin Blaimer, Peter M. Jakob, Mark A. Griswold

Simplified Iterative GRAPPA for Fast and Robust Parallel MRI with Arbitrary Trajectories ...... 3294 Martin Blaimer, André Fischer, Philipp Ehses, Nicole Seiberlich, Mark A. Griswold, Peter M. Jakob,Felix A. Breuer

Creation of Arbitrary Spatial Harmonics Though the Combination of Orthogonal Weights (CASHCOW): a Generalized Direct GRAPPA Approach for Non-Cartesian Data...... 3295 Nicole Seiberlich, Felix A. Breuer, Stephen R. Yutzy, Martin Blaimer, Mark A. Griswold

Anisotropic Kernel Support for Improved Fast GRAPPA Imaging ...... 3296 Jun Miao, Wilbur C. K. Wong, David L. Wilson

Optimizing the Net Acceleration of GRAPPA and PEAK-GRAPPA...... 3297 Simon Bauer, Michael Markl, Bernd Andre Jung

Field Strength and B1 Influence on Kernel Support Selection for Highly Accelerated GRAPPA Reconstruction...... 3298 Jun Miao, Wilbur C. K. Wong

A Fast Jump Move Graph Cut Reconstruction Algorithm for MR Parallel Imaging...... 3299 Ashish Raj, Gurmeet Singh, Yi Wang, Ramin Zabih

IRES: Self-Calibrated Parallel Imaging with No Loss of Net Acceleration...... 3300 Ek Tsoon Tan, Roger C. Grimm, Stephen J. Riederer

Improved Self-Referenced Parallel MRI Imaging in EPI by Using UNFOLD to Remove Nyquist Ghosts...... 3301 W Scott Hoge, Huan Tan, Robert A. Kraft

Improved Reconstruction in Non-Cartesian Parallel Imaging by Regularized Nonlinear Inversion...... 3302 Florian Knoll, Christian Clason, Martin Uecker, Rudolf Stollberger

Rapid Parallel Imaging Reconstruction of NonCartesian Data...... 3303 James G. Pipe

Parallel Reconstruction of Projection MRI...... 3304 Alan B. McMillan

Robust SENSE Reconstruction Using Non-Local Regularization ...... 3305 Sheng Fang, Li Zhao, Xinlu Xu, Kui Ying, Jiangping Cheng

Prewhitening and Maximum Likelihood Estimation for Root-Sum-Of-Squares Images ...... 3306 Ryan Fobel, Greg J. Stanisz

A Point Spread Function Based Measure of Artefact in Parallel MRI Reconstruction...... 3307 Linghe Yang, Phil Robson, Charles McKenzie

Feasibility of Direct Virtual Coil (DVC) Reconstruction for 3-D Imaging...... 3308 Philip James Beatty, Joseph Y. Cheng, Ajit Shankaranarayanan, Ananth Madhuranthakam, Huanzhou Yu, Ersin Bayram, Shaorong Chang, Jean H. Brittain

Efficient Large-Array K-Domain Parallel MRI Using Channel-By-Channel Array Reduction...... 3309 Jim Ji, Shuo Feng

Prospective SNR Optimization in k-T-Based Sensitivity-Encoded Dynamic Imaging Using a Fast Geometric Algorithm ...... 3310 Behzad Sharif, John Andrew Derbyshire, Yoram Bresler

Dynamically Regularized TSENSE Improves Image Quality in Parallel MRI...... 3311 Martin Blaimer, Felix A. Breuer, Peter M. Jakob, Mark A. Griswold, Peter Kellman

Time Efficient Parallel Imaging for 2D Multi-Slice MRI with Continuously Moving Table ...... 3312 Matthias Honal, Ute Ludwig, Jochen Leupold

Temporal Filtering Effects in Auto-Calibrating TSENSE...... 3313 Peter Kellman, Martin Blaimer, Felix Breuer, Mark Griswold

3101 ...... 3314 Ke Liu, Jingxin Zhang, Ran Yang, Cishen Zhang

High Temporal and Spatial Resolution 3D CE-MRA of the Peripheral Vascualture Using 12-Fold 2D SENSE ...... 3315 Clifton R. Haider, James F. Glockner, Anthony W. Stanson, Casey P. Johnson, Stephen J. Riederer

Efficient Parallel Imaging Strategies for Time-Of-Flight Venography with Continuously Moving Table...... 3316 Matthias Honal, Sandra Huff

High Resolution Single-Shot Diffusion Weighted Imaging with a Combination of Zoomed EPI and Parallel Imaging ...... 3317 Robin Martin Heidemann, Thorsten Feiweier, Alfred Anwander, Fabrizio Fasano, Josef Pfeuffer,Robert Turner

Parallel Line-Scan Echo-Planar Spectroscopic Imaging ...... 3318 Yoshitaka Bito, Toru Shirai, Satoshi Hirata, Yo Taniguchi, Koji Hirata, Yosuke Otake, Yoshihisa Soutome, Hisaaki Ochi, Toshihiko Ebisu, Yuko Kawai, Masahiro Umeda, Toshihiro Higuchi, Chuzo Tanaka

Parallel Imaging with RASER Using Multiband Frequency-Modulated Excitation Pulses...... 3319 Tram Nguyen, Ute Goerke, Steen Moeller, Kamil Ugurbil, Michael Garwood

Correlation of Tissue Proteomic Profiles with MR Measures in a Rat Brain ...... 3320 Tuhin K. Sinha, Zhengyu K. Yang, Erin H. Seeley, Mary Loveless, Daniel C. Colvin, Richard M. Caprioli, John C. Gore

T2 Estimation for Small Lesions Using a Model-Based Reconstruction with Sparsifying Penalty Functions and Highly Under-Sampled Radial FSE Data ...... 3321 Chuan Huang, Ali Bilgin, Christian Graff, Maria I. Altbach

Optimisation of the Combined Gradient Echo/spin Echo (GESE) Sequence for the Measurement of T2 at 7.0 T...... 3322 Eleanor F. Cox, Penny A. Gowland

Non-Regularized Multivoxel NNLS Is a Robust Analysis Approach to Quantitative T2 ...... 3323 Thorarin A. Bjarnason, Cheryl R. McCreary, Jeff F. Dunn, J Ross Mitchell

Localized In Vivo Fast Field-Cycling Relaxometry...... 3324 Kerrin J. Pine, Gareth R. Davies, David J. Lurie

Voxel-Based Relaxometry for Cases of an Unresolved Epilepsy Diagnosis...... 3325 Robert Karl Kosior, Rachel Sharkey, Paolo Federico, Richard Frayne

Comparison of Analysis of Brain Relaxation Times in Standard Space with Analysis in Individuals’ Real Space ...... 3326 Benjamin Segun Aribisala, Andrew M. Blamire

Detection of Changes in T1 Values in Normal Brain During Normobaric Hyperoxia...... 3327 Samantha Jane Mills, Gerard Thompson, Giovanni Alessandro Buonaccorsi, Geoff J. Parker, Alan Jackson

Off-Resonance Magnetisation Transfer Contrast MRI Using Fast Field-Cycling Technique ...... 3328 Chang-Hoon Choi, Gareth R. Davies, David J. Lurie

Optimization and Validation of a Constrained Reconstruction Algorithm for Rapid Whole-Brain Cross-Relaxation Imaging at 3.0 Tesla ...... 3329 Hunter R. Underhill, Chun Yuan, Vasily L. Yarnykh

Direct Quantitative Comparison Between Cross-Relaxation Imaging and Diffusion Tensor Imaging of the Human Brain...... 3330 Hunter R. Underhill, Chun Yuan, Vasily L. Yarnykh

19F Signal Amplification by Heteronuclear Polarization Transfer...... 3331 Florian Schmid, Manuel Tsotsalas, Michael Kuhlmann, Carsten Höltke, Christoph Bremer, Walter Heindel, Andres Guerrero- Martinez, Jochen Keupp, Michael Schäfers, Luisa De Cola, Cornelius Faber

Incorporation of ADC Information Into SMM-Based MREIT for Small Animal Conductivity Imaging...... 3332 Mark Jason Hamamura, Orhan Nalcioglu, Lufti Tugan Muftuler

SENSE Accelerated MREIT with Optimized RF Coil Design ...... 3333 Lutfi Tugan Muftuler, Gang Chen, Mark J. Hamamura, Orhan Nalcioglu

Bright-Iron Imaging Applying an Off-Resonance Modulating Pre-Pulse (OMPP)...... 3334 Volker Rasche, Vinzenz Hombach, Sonu Sharma, Gerlinde Schmidtke-Schrezenmeier, Axel Bornstedt

Positive Iron Contrast by Flow Enhanced Off-Resonance-Saturation for Remote Detection of Iron Based Contrast Agents...... 3335 Philipp Krämer, Xavier Helluy, Esra Lang, Peter Michael Jakob

Switching of MRI Contrast Agents with Ultrasound ...... 3336 Nouri Elmiladi, Christian Hoehl, Karl Maier

Numerical Study of the Distant Dipolar Field...... 3337 Stefan Kirsch, Peter Bachert

CRAZED Signal Dependence on Correlation Distance and Sample Orientation in Rat Sciatic Nerve ...... 3338 Arman S. Kussainov, Mark D. Does, Nellie E. Byun, John C. Gore, Daniel F. Gochberg

Observation of Signal Dips in IMQC Study ...... 3339 Zhong Chen, Shengchun Zhang, Shuhui Cai

T1 Contrast in the Human Brain at 7 Tesla ...... 3340 Michael Wyss, David Otto Brunner, Anne Morel, Klaas Paul Pruessmann

Magnetization Prepared 3D FLAIR Imaging at 7.0 Tesla...... 3341 Fredy Visser, Jaco Zwanenburg, Hans Hoogduin, Peter Luijten

3D FLAIR at 7 Tesla Highlights Peripheral Layers of the Cortex ...... 3342 Jaco J.M. Zwanenburg, Fredy Visser, Taro Takahara, Wim G.M. Spliet, Peter R. Luijten

Reconstruction of Multi-Channel MR Magnitude and Phase Images Using Dual-Echo Sequence at 7 Tesla ...... 3343 Chan Hong Moon, Kyongtae Ty Bae

Phase Contrast in the Human Brain and Its Field Dependence...... 3344 Ana Maria Oros-Peusquens, Miriam Rabea Kubach, N. Jon Shah

Triple-Layer Appearance of Human Cerebral Cortices on Phase-Difference Enhanced Imaging Using 3D Principle of Echo Shifting with a Train of Observations (PRESTO) Sequence...... 3345 Tetsuya Yoneda, Toshinori Hirai, Yasuhiro Hiai, Hiroki Arimura, Yoko Kitajima, Tomoyo Ideta, Mika Kitajima, Yasuyuki Yamashita

Robust Fast Clinical Neurological Examination Using Golden Angle Ordered Radial IR-TrueFISP...... 3346 Stephen R. Yutzy, Nicole Seiberlich, Vikas Gulani, Jeffrey L. Duerk, Mark A. Griswold

The Effect of B0 Inhomogeneity on the SSFP Dixon Technique: A Comaprison of Variants...... 3347 Yin-Cheng Kris Huang, Teng-Yi Huang, Hing-Chiu Chang, Hsiao-Wen Chung

Chimera Steady State Free Precession (Chimera SSFP) ...... 3348 Oliver Bieri, Markus Klarhöfer, Klaus Scheffler

Multiple Acquisition Fat-Saturated Balanced Steady State Free Precession Imaging...... 3349 Marcus T. Alley, Shreyas S. Vasanawala, Robert J. Herfkens, Brian A. Hargreaves

Investigation of SPIO T1-Signature: Positive Contrast Using Ultrashort TE Imaging ...... 3350 Olivier Maciej Girard, Jiang Du, Robert Frederick Mattrey

Imaging of Short T2 and Ultra-Short T2 Tissues Using R2 Map ...... 3351 Weitian Chen, Huanzhou Yu, Atsushi Takahashi, Anja Brau, Jeffrey Stainsby, Ann Shimakawa, Brian A. Hargreaves, Garry E. Gold

Application of 3Dcones Sequence for Ultra-Short Echo Time Imaging...... 3352 Jian-Xiong Wang, Brian K. Rutt, Jeffrey A. Stainsby

MP-SWIFT with Adiabatic Inversion Preparation for Quiet, B1 Insensitive T1 Weighted Imaging ...... 3353 Curtis Andrew Corum, Djaudat Idiyatullin, Steen Moeller, Michael Garwood

Enhancing Lipid Signals with SWIFT ...... 3354 Lauri Juhani Lehto, Curt Corum, Djaudat Idiyatullin, Michael Garwood, Olli Gröhn

Estimation of Attenuation Maps from UTE Derived R2 Images...... 3355 Vincent Keereman, Yves De Deene, Tom Broux, Ignace Lemahieu, Stefaan Vandenberghe

Multi-Echo IDEAL Cardiac Water-Fat Imaging ...... 3356 Karl Kristopher Vigen, Christopher J. Francois, Huanzhou Yu, Ann Shimakawa, Jean H. Brittain, Scott B. Reeder

Spatially Variable Fat-Water Separation Using Short 2DRF Pulses for Fast Imaging ...... 3357 Jing Yuan, Bruno Madore, Lawrence P. Panych

Coil Combination Method for Multiple-Echo Sequences and PSF Mapping...... 3358 Kun Zhou, Shanglian Bao, Juergen Hennig, Maxim Zaitsev

Iterative Tuning of System Delay and Phase Correction for Echo-Planar Imaging...... 3359 Holger Eggers

Self-Correction of Image Distortion in High-Field EPI Using EPI Phase...... 3360 Kathryn E. Hammond, Duan Xu, Doug AC Kelley, Sarah J. Nelson

Fieldmap-Free Retrospective Registration and Distortion Correction for EPI-Based Diffusion-Weighted Imaging ...... 3361 Clare Poynton, Mark Jenkinson, Carlo Pierpaoli, William Wells III

Noise Considerations in Slice Encoding for Metal Artifact Correction ...... 3362 Wenmiao Lu, Kim Butts Pauly, Garry Evan Gold, John Mark Pauly, Brian Andrew Hargreaves

Phase Angle Tilting (PAT) for Distortion Correction Caused by Susceptibility in EPI...... 3363 Lirong Yan, Deheng Weng, Rong Xue, Jiongjiong Wang, Yan Zhuo

Parallel MRI Near Metallic Implants ...... 3364 Weitian Chen, Philip Beatty, Kevin Koch, Anja Brau

A Novel Algorithm for the Correction of Eddy Current Distortion in Diffusion Weighted Imaging Data ...... 3365 Wei Liu, Guang Yang, Zhenyu Zhou, Yongdi Zhou, Gengying Li, Bradley S. Peterson, Dongrong Xu

Correcting Phase Errors from B0 Eddy Currents in Non-Cartesian Imaging ...... 3366 Ethan K. Brodsky, Jessica L. Klaers, Walter F. Block

Quantifying Changes in Geometric Distortion Across a Gradient Coil Replacement...... 3367 Jonathan Samuel Jackson, Daniel Tozer, Mark Symms, Claudia A. M. Wheeler-Kingshott

A Generic Method of Quantifying Geometric Distortion Using Non-Linear Registration and a 3D Phantom...... 3368 Jonathan Samuel Jackson, Daniel Tozer, Jerome M. Goffin, John S. Thornton, Paul S. Tofts, Claudia A.M. Wheeler-Kingshott, Mark Symms

Sample-Specific Passive Shimming Using Optimization Algorithm...... 3369 Sejung Yang, Hahnsung Kim, Sang-Young Zho, Byung-Uk Lee, Dong-Hyun Kim

Dynamic Magnetic Field Corrections Improve Phase-Only fMRI Activations...... 3370 Andrew David Hahn, Andrew S. Nencka, Daniel B. Rowe

Application of K-Space Energy Spectrum Analysis for Inherent and Dynamic B0 Mapping and Deblurring in Spiral Imaging ...... 3371 Trong-Kha Truong, Nan-kuei Chen, Allen W. Song

B0 Field Monitoring by Air-Matched Phantoms...... 3372 Frederik Testud, Maxim Zaitsev

On Dephasing Effects in Complex Projection Data: Implications for Rapid B0 Estimation...... 3373 Daniel Nicolas Splitthoff, Maxim Zaitsev

The Impact of Finite RF Excitation on Steady State Free Precession...... 3374 Oliver Bieri, Klaus Scheffler

Evaluation of a Template-Based B1 Field Correction Approach for 3T MRI Brain Images...... 3375 Marcelo Adrian Castro, Jianhua Yao, Christabel Lee, Yuxi Pang, Eva Baker, John Butman, David Thomasson

Inherent Insensitivity to B1 Field Inhomogeneity Using Regularized Nonlinear Inversion Reconstruction...... 3376 Aiming Lu, Keith R. Thulborn

Optimization and Group Comparison of RF (B1) Mapping Methods at 3T ...... 3377 Antoine Lutti, Chloe Hutton, Gunther Helms, Jurgen Finsterbusch, Nikolaus Weiskopf

Optimization of 3D EPI Technique for Radio Frequency (B1) Field Mapping at 3T ...... 3378 Antoine Lutti, Chloe Hutton, Nikolaus Weiskopf

UTE Excitation Pulses Followed by Spin Lock to Preserve Magnetization...... 3379 Michael Carl, Mark Bydder, Atsushi Takahashi, Eric Han, Graeme Bydder

Characterizing and Correcting Gradient Errors in Non-Cartesian Imaging: Are Gradient Errors Linear Time- Invariant?...... 3380 Ethan Brodsky, Walter F. Block k-Space Water-Fat Decomposition with Chemical Shift Correction and T2 Decay Compensation for Ultrashort TE Imaging ...... 3381 Kang Wang, Jiang Du, Huanzhou Yu, Jean H. Brittain, Scott B. Reeder

Computer Simulation for Evaluating MR Image Artifacts Caused by Magnetic Field Fluctuations Induced by Gradient Pulses...... 3382 Yo Taniguchi, Suguru Yokosawa, Yoshitaka Bito

Reduction of FSE Cusp Artifact Using Slice Tilting...... 3383 Novena Rangwala, Xiaohong Joe Zhou

A Method to Measure Gradient Delay Due to Gradient Coupling...... 3384 Ajit Devaraj, James G. Pipe

Navigator-Stabilized GRASE Imaging for High Magnetic Fields ...... 3385 Daniel Gembris, Anita Siebert, Franzisek Hennel k-Space Trajectory Mapping for Ultra-Short, Single-Shot, Non-Cartesian Imaging ...... 3386 Florian Wiesinger, Pekka Tapani Sipilae, Yi-Fen Yen, Dirk Mayer, Eric Fiveland, Sebastian A.Greding, Daniel M. Spielman, Adolf Pfefferbaum, Rolf F. Schulte

Robust Compensation of Magnetic Field Perturbations for Localized Spectroscopy Applications ...... 3387 Caixia Fu, GuoBin Li

Robust Volume Segmentation Using Noise Statistics of Phase and Magnitude ...... 3388 Yiping P. Du, Zhaoyang Jin, Yuzheng Hu

Removing Phase Artifacts Using Fourier Transform Based Field Estimation Can Lead to Significant Improvement in Phase Unwrapping Based SWI Processing...... 3389 Jaladhar Neelavalli, Yu-Chung Norman Cheng, Jing Jiang, Ewart Mark Haacke

A Multi-Mask Multi-Seed Free Growing Field Map Estimation Algorithm for Iterative Multi-Point Water-Fat Decomposition...... 3390 Chuan Huang, Maria I. Altbach

Challenges for MR-Based Attenuation Correction in PET Imaging of the Head...... 3391 Andre Jan Willem van der Kouwe, Ciprian Catana, Thomas Benner, Christian J. Michel, Michael Hamm, Sonia Nielles-Vallespin, Stephan Kannengiesser, Matthias Fenchel, Bruce R. Rosen, A. Gregory Sorensen

Gradient Echo Assisted 3D Look-Locker - A Method for Improved Volume T1-Quantification Accuracy Applied to DGEMRIC ...... 3392 Carl Siversson, Carl-Johan Tiderius, Leif Dahlberg, Jonas Svensson

Accelerated MR Parameter Mapping Using Compressed Sensing with Model-Based Sparsifying Transform...... 3393 Mariya Doneva, Julien Sénégas, Peter Börnert, Holger Eggers, Alfred Mertins

A Combination of Nonconvex Compressed Sensing and GRAPPA (CS-GRAPPA) ...... 3394 Andre Fischer, Nicole Seiberlich, Martin Blaimer, Peter Jakob, Felix Breuer, Mark Griswold

Compressed Sensing Using Dual-Tree Complex Wavelet Transform...... 3395 Yookyung Kim, Maria I. Altbach, Theodore P. Trouard, Ali Bilgin

Compressed Sensing in Parallel Imaging: Towards Optimal Sampling ...... 3396 Panu Tapani Vesanen, Fa-Hsuan Lin, Risto Juhani Ilmoniemi

Region of Interest Compressed Sensing...... 3397 Samir D. Sharma, Krishna S. Nayak

Compressed Sensing with Vascular Phase Contrast Acquisition...... 3398 Kevin F. King, Wei Sun

Case-PDM Optimized Random Acquisition in High Quality Compressed Sensing MR Image Reconstruction ...... 3399 Jun Miao, Feng Huang, David L. Wilson

Accelerated High-Resolution Imaging of Trabecular Bone Using Total Variation Constrained Reconstruction ...... 3400 Michael J. Wald, Ganesh Adluru, Hee Kwon Song, Felix W. Wehrli

Nullspace Compressed Sensing for Accelerated Imaging ...... 3401 Leo J. Grady, Jonathan R. Polimeni

Accelerated Free Breathing MRI with Continously Moving Table Using Compressed Sensing ...... 3402 Matthias Honal, Jochen Leupold, Ute Ludwig

Adaptive Regularization in Compressed Sensing Using the Discrepancy Principle...... 3403 Kevin F. King, Luca Marinelli, Christopher J. Hardy

Compressed Sensing with Phase Constrained Partial Radial K-Space...... 3404 Ali Bilgin, Yookyung Kim, Vineeth Abraham, Theodore P. Trouard, Maria I. Altbach

Sequential Application of Parallel Imaging and Compressed Sensing...... 3405 Philip James Beatty, Kevin F. King, Luca Marinelli, Chris J. Hardy, Michael Lustig

Reconstruction of Undersampled MR Data Using Lp (0

Catheter Visualization for Endovascular MR Using Compressive Sampling: Comparison Against POCS...... 3407 Jerome Yerly, M Louis Lauzon, Henry S. Chen, Richard Frayne

Accelerated 2D Fourier-Velocity Encoded MRI Using Compressed Sensing ...... 3408 Luca Marinelli, Kedar Khare, Kevin F. King, Robert Darrow, Christopher J. Hardy

Auto-Calibration Method for K-T-SENSE: Using TGRAPPA to Calculate the Training Data ...... 3409 Paola Irene Ponce, Martin Blaimer, Felix A. Breuer, Peter M. Jakob, Mark A. Griswold, Peter Kellman

Optimal Method for Obtaining Dynamic Phase Images from Multi-Channel EPI Data...... 3410 Erik B. Beall, Ken E. Sakaie, Kecheng Liu, Pallab K. Bhattacharyya, Mark J. Lowe

Constrained Reconstruction of Dynamic Contrast Enhanced Tumor MR Data with Respiratory Self-Gating ...... 3411 Ganesh Adluru, Wei Lin, Mark Rosen, Hee Kwon Song

Fast and Motion Robust R2 Reconstruction for Functional MRI ...... 3412 Valur Olafsson, Jeffrey A. Fessler, Douglas C. Noll

Analytical Analysis of the Accuracy of HYPR LR in CE MRA...... 3413 Huimin Wu, Alexey A. Samsonov, Julia Velikina, Walter F. Block

Motion Compensated Reconstruction for Free Breathing Dynamic Constrast-Enhanced MRI ...... 3414 Marina Filipovic, Pierre-André Vuissoz, Michel Claudon, Jacques Felblinger

Time-Resolved Imaging with Multiplicative Algebraic Reconstruction Technique (MART): An Application of HYPR Principles for Variable Density Cartesian Acquisitions ...... 3415 Reed F. Busse, Angel R. Pineda, Kang Wang, James H. Holmes, Jean H. Brittain, Frank R. Korosec

Iterative Soft-Thresholding Reconstruction for Time-Of-Flight MR Angiography...... 3416 Kedar Khare, Luca Marinelli, Christopher J. Hardy, Kevin F. King

Improved Temporal Resolution in Radial K-Space Sampling Using an Hourglass Filter...... 3417 Maria Magnusson, Olof Dahlqvist Leinhard, Patrik Brynolfsson, Peter Lundberg

2D Graphical Assessment for Fast Imaging Strategies ...... 3418 Tzu-Cheng Chao, Hsiao-Wen Chung, William Scott Hoge, Jing Yuan, Bruno Madore

Real-Time Elimination of Undersampling Artifacts Using 3D Total Variation on Graphics Hardware...... 3419 Florian Knoll, Markus Unger, Franz Ebner, Rudolf Stollberger

Online Real-Time Reconstruction of Adaptive TSENSE with Commodity CPU /GPU Hardware...... 3420 Sébastien Roujol, Baudouin Dennis De Senneville, Erkki Vahala, Thomas Sangild Sørensen, Chrit Moonen, Mario Ries

Segmentation of Multiple Sclerosis Lesions Using Quantitative MRI...... 3421 Dagmar R. Lang, Veronika Ermer, N. Jon Shah, Heiko Neeb

Artifact-Free and Multi-Contrast SSFP Imaging Achieved in a Single Acquisition ...... 3422 Ming-Long Wu, Nan-Kuei Chen

Improved Image Reconstruction for Multi-Shot Multi-Coil Diffusion Imaging...... 3423 Martin Uecker, Alexander Karaus, Jens Frahm

Tradeoffs in Supersampling of DTI Metrics ...... 3424 Jadrian Miles, Ron A. Cohen, David H. Laidlaw

Fast Concomitant Gradient Field Correction for Spiral Scans...... 3425 Joseph Yitan Cheng, Juan M. Santos, John M. Pauly

Improved Gradient Field Distortion Correction in Continously Moving Table Acquisitions Using GIRAFFE...... 3426 Rita Gouveia Nunes, Joseph V. Hajnal, David J. Larkman

Water-Fat Decomposition with MR Data Based Regularized Estimation in MRI ...... 3427 Won Seok Huh, Jeffrey A. Fessler

Independent Estimation of T2 for Water and Fat for Improved Accuracy of Fat Quantification ...... 3428 Venkata Veerendranadh Chebrolu, Catherine D G Hines, Huanzhou Yu, Angel R. Pineda, Ann Shimakawa, Charles McKenzie, Jean H. Brittain, Scott B. Reeder

Robust Multicoil Reconstruction for Phase-Sensitive Fat-Water Separation ...... 3429 Tolga Çukur, Brain A. Hargreaves, Dwight G. Nishimura

Water-Fat Imaging by Direct Phase Encoding with Solution Along Isophasic Lines (SAIL) ...... 3430 Qing-San Xiang

Phase Optimized Sensitivity Estimation Method for SENSE...... 3431 Zhaolin Chen, Leigh Johnston, Zang-Hee Cho, Gary Egan

Accelerating Sparse Object Imaging by Simplified Skipped Phase Encoding and Edge Deghosting with Array Coil Enhancement (SPEED-ACE) ...... 3432 Zheng Chang, Qing-San Xiang, Fang-Fang Yin

Performance of Three Parallel MRI Reconstruction Methods in the Presence of Coil Sensitivity Map Errors...... 3433 Lotfi Chaâri, Philippe Ciuciu, Amel Benazza-Benyahia, Jean-Christophe Pesquet

Boosting Image Quality by Automatic Low SNR Channel Detection and Its Removal in K-Space ...... 3434 Christian Ros, Jan Sedlacik, Najat C. Daw, Ralf Loeffler, Juergen R. Reichenbach, Claudia M. Hillenbrand

Fast Phase Unwrapping Using Fourier Transform ...... 3435 Amir M. Abduljalil, Seongjin Choi, Michael Vincent Knopp, Petra Schmalbrock

Coil Array Compression in Coronary MRA ...... 3436 Johannes Frieder Schmidt, Martin Buehrer, Peter Boesiger, Sebastian Kozerke

Hybrid Roemer Reconstruction for Multi-Element TX/RX Body Coil at 3T ...... 3437 Kay Nehrke, Klaus Michael Uhr, Peter Börnert

Kaczmarz Iterative Reconstruction for Arbitrary Hybrid Encoding Functions ...... 3438 Jason Peter Stockmann, Robert Todd Constable

A Phase Constrained Graph Cut Algorithm for Reconstruction of MR Parallel Imaging Under 3D Spatial Priors...... 3439 Ashish Raj, Ramin Zabih

Extended Anti-Aliasing Reconstruction for Phase-Scrambled MRI with Quadratic Phase Modulation ...... 3440 Maxim Zaitsev, Gerrit Schultz, Jürgen Hennig

Generalized Reconstruction of Multi-Spectral MR Acquisitions for Imaging Near Metal Implants...... 3441 Diego Hernando, Kevin M. Koch, Kevin F. King, Zhi-Pei Liang

Bayesian Reconstruction of DW-PROPELLER Images Using Joint Entropy...... 3442 Jinhua Sheng, Dong Liang, Jing Tang, Donglai Huo, Leslie Ying

Resolution and Noise Properties of Linear Phase-Constrained Partial Fourier Reconstruction...... 3443 Justin P. Haldar, Kenneth Sakaie, Zhi-Pei Liang

Data Interpolation in Phase-Scrambling Fourier Transform Technique for Alias-Free Image Reconstruction by Iterative Signal Restoration Algorithm...... 3444 Yoshifumi Yamada, Satoshi Ito

Iterative Reconstruction for Off-Resonance Effects in SWIFT Imaging...... 3445 Steen Moeller, Djaudat Idiyatullin, Curt Corum, Rong Zhou, Michael Garwood

Including Prior Knowledge in the Reconstruction of ASL Perfusion Images to Reduce Noise and Improve Spatial Resolution...... 3446 Philip M. Robson, David C. Alsop

Estimation of Tissue at Risk of Infarction Using a Support Vector Machine on Multimodal Stroke MRI Data ...... 3447 Susanne Schnell, Irina Mader, Dorothee Saur, Kim Mouridsen, Roza Umarova, Dorothee Kümmerer,Hans Burkhardt, Valerij G. Kiselev

Direction of Plaque Progression Is a Significant Predictor in Plaque Vulnerability: An Evaluation by MRI...... 3448 Dongxiang Xu, Chun Yuan

The Optimised Projection Image Method for Targeted Tissue Contrast Enhancement ...... 3449 Amanda Ching Lih Ng, Nathan Faggian, Zhaolin Chen, Jingxin Zhang, Gary F. Egan, Leigh A.Johnston

Enhancement of Venous Vasculature in the Brain with Multi-Scale Filtering ...... 3450 Zhaoyang Jin, Ling Xia, Yiping Peter Du

Semi-Automated Volume Segmentation of the Brain Based on a Level Set Approach...... 3451 Zhaoyang Jin, Ling Xia, Yiping Peter Du

Segmentation of Amyloid Plaques in MR Images of the APP Transgenic Mouse Brain Using SVM...... 3452 George Iordanescu, Palamadai Venkatasubramanian, Alice Wyrwicz

Determination of Whole Body Fat and Visceral Adipose Tissue, Combining Three Volume Estimation Methods ...... 3453 Tania Buehler, Daniel GQ Chong, Chris Boesch

Establishment of a Novel Automated Approach for Quantification of Subcutaneous and Visceral Adipose Tissues: Correlates with Other Anthropometric Measurements and Cardiometabolic Risk Factors ...... 3454 Sarayu Annamalai Parimal, Karren Hui Min Chen, Suresh Anand Sadananthan, Sam Sim, Vitali Zagorodnov, Michael WL Chee

Automatic Liver Segmentation of 3D Abdominal MR Images of Rodents...... 3455 Way Cherng Chen, Ying Min Wang, Kai-hsiang Chuang, Xavier Golay, Anqi Qiu

Influence of a Partial Volume Effect in the Segmentation of Brain Tissue Based on Diffusion Tensor Imaging (DTI) Data: A Digital DTI Phantom Study ...... 3456 Seiji Kumazawa, Takashi Yoshiura, Hiroshi Honda, Fukai Toyofuku, Yoshiharu Higashida

MR ONCO-TREAT: a New Tool for Volumetric and Functional Analysis of Hepatic Tumors Monitored with Multi-Modal MRI...... 3457 Mehmet Akif Gulsun, Clifford Raabe Weiss, Ralph Strecker, Glenn Meredith, Ihab R. Kamel

Comparison of Brain Segmentation Results Using Automated FSL-FAST with DTI Channel Inputs...... 3458 Elizabeth Zakszewski, Deok Han, Jee Eun Lee, Vikas Singh, Andrew L. Alexander

Optimizing N3 Parameters Leads to Better Segmentation Accuracy on 3T Scanners...... 3459 Weili Zheng, Michael WL Chee, Vitali Zagorodnov

Use of Lesion Walker Classification in Patients with Multiple Sclerosis ...... 3460 David Scott Wack, Michael G. Dwyer, Jackie Durfee, Sara Hussein, Deepa P. Ramasamy, Niels Bergsland, Robert Zivadinov

Validation of Fat Volume Quantification with IDEAL MRI...... 3461 Abdullah Alabousi, Salam Al-Attar, Tisha R. Joy, Robert A. Hegele, Charles A. McKenzie

Three-Dimensional (3-D) Segmentation of Knee Cartilage from 3.0 T MR Images Using a Graph-Cuts Technique...... 3462 Hackjoon Shim, Samuel Chang, Cheng Tao, Jinhong Wang, Kyongtae Ty Bae

Deterministic Automatic Segmentation in MRI, CT and CTA: A Robust Method Based on Anatomical Structures Modelling and Local Recursive Intensity Analysis...... 3463 Manfredo Atzori, Gianluca Rambaldelli, Paolo Brambilla, Alessandra Bertoldo

Towards Localization of Transcranial Magnetic Stimulation Inside the MRI Scanner ...... 3464 Aranee Techawiboonwong, Alvaro Pascual-Leone, Daeshik Kim, Itamar Ronen

Changes in in Vivo Tibiofemoral Cartilage-To-Cartilage Contact Area Under Acute Loading; Comparison of Two Sequences (3D-SPGR Vs. T2-Weighted FSE) ...... 3465 Choongsoo S. Shin, Richard B. Souza, Xiaojuan Li, Brad Wyman, Thomas M. Link, C Benjamin Ma, Sharmila Majumdar

Automated Segmentation of 3D Histological Mouse Brains Using a MRI-Based 3D Digital Atlas ...... 3466 Jessica Lebenberg, Anne-Sophie Hérard, Albertine Dubois, Marc Dhenain, Philippe Hantraye, Vincent Frouin, Thierry Delzescaux

Semi-Automatic Segmentation of Mouse Embryo MRIs...... 3467 Leila Baghdadi, John G. Sled, Jurgen E. Schneider, R Mark Henkelman, Jason P. Lerch

Automatic Identification and Segmentation of Infarct Lesions from Diffusion Weighted MR Images and ADC Maps...... 3468 Suja Saraswathy, Saurabh Sharma, Dattesh Shanbhag, Uday Patil, Rakesh Mullick

A Multi-Strategy Method for MRI Segmentation ...... 3469 Miguel Martin-Landrove, Gabriel Padilla, Giovanni Figueroa, Marco Paluszny, Wuilian Torres

Identification of Functional Subunits of the Human Cortex Using Resting State fMRI...... 3470 Xilin Shen, Fuyuze S. Tokoglu, Jennifer K. Roth, Xenophon Papademetris, Robert Todd Constable

Improved Skull Stripping Using Graph Cuts...... 3471 Suresh Anand Sadananthan, Weili Zheng, Michael WL Chee, Vitali Zagorodnov

Automatic Extraction of 3D Cortical Profiles as the Basis for Anatomically-Based Cortical Parcellation ...... 3472 Marcel Weiss, Gabriele Lohmann, Gerik Scheuermann, Robert Turner

The EMD-Test for Shape-Based Morphometry...... 3473 Nathan Faggian, India Bohanna, Leigh A. Johnston, Nellie Georgiou-Karistianis, Gary Francis Egan

Quantitative Voxel-Based Analysis of T1-Weighted MRI Signal Intensity ...... 3474 David Fenton Abbott, Gaby S. Pell, Heath Pardoe, Graeme D. Jackson

MR Brain 3D Contouring Using Atlas Matching and Snake Edge Detection Combined Approach...... 3475 Robert Ambrosini, Walter O'Dell

A Geo Cut Algorithm for Brain MRI Segmentation ...... 3476 Jie Zhu, Ashish Raj, Ramin Zabih

Reliable Segmentation of Subcortical Gray Matter Structures Using Magnetization Transfer (MT) Maps ...... 3477 Nikolaus Weiskopf, Bogdan Draganski, Richard Frackowiak, John Ashburner, Gunther Helms

A Rat Brain Template of Class Distribution Maps Based on Diffeomorphic Image Registration...... 3478 Lei Zheng, Sarah Biedermann, Jürgen Hesser, Alexander Sartorius, Wolfgang Weber-Fahr

Assessing the Impact of Image Registration on Texture Analysis of MR Images...... 3479 Henry Tran, Roger Tam, Anthony Traboulsee, David Li

Integration of Model Information Into Model-Free Multivariate Analyses of Structural and Diffusion MRI Data ...... 3480 Stephen Smith, Achim Gass, Andreas U. Monsch, Anil Rao, Brandon Whitcher, Paul M. Matthews,Christian Beckmann

Establishing Probabilistic Chinese Human Brain Templates Using HAMMER Elastic Registration Algorithm ...... 3481 Zhentao Zuo, Xing Wang, Nan Chen, Jing Luo, Yan Zhuo, Dinggang Shen, Kuncheng Li, Rong Xue

Fully Automated DTI Postprocessing Embedded in Scanner Control Software: Deghosting, Denoising, Smoothing, and Registration to a Standard Atlas...... 3482 Kurt Hermann Bockhorst, Jaivijay Ramu, Venkata Kishore Mogatadakala, Cheukkai K. Hui, Ponnada A. Narayana

Automated Registration of Sequential Breath-Hold DCE-MRI Images...... 3483 Sivaramakrishnan Rajaraman, Jeffery J. Rodriguez, Christian Graff, Maria I. Altbach, Tomislav Dragovich, Claude B. Sirlin, Ronald L. Korn, Natarajan Raghunand

Automatic Scan Plane Planning Method for Brain MRI...... 3484 Xiaodong Tao, Sandeep Narendra Gupta

Automatic Detection of Quiescent Cardiac Phases Using Navigator Echoes with Adjacent Complex Correlation Algorithm ...... 3485 Maggie M. Fung, Vincent B. Ho, Maureen N. Hood, Yuval Zur, Ehud J. Schmidt

Deformation Based Morphometry with Implicit Reference-Based Registration: Validation and Detection of Structural Changes in a Primate Model of Early-Life Stress...... 3486 Xiujuan Geng, Thomas J. Ross, Svetlana Chefer, Hong Gu, Elliot Stein, Yihong Yang

Assessment of SPM5’s Brain Registration Performance Using Landmark Points...... 3487 Joao Miguel Pereira, Guy B. Williams, Li Xiong, Julio Acosta-Cabronero, George Pengas, Peter J. Nestor

Retrospective Evaluation of Brain PET-MR Registration ...... 3488 Zuyao Y. Shan, Sara J. Mateja, Wilburn E. Reddick, John O. Glass, Barry L. Shulkin

Scaling Methods for Registration of Pre- And Post-Androgen Ablation MR Prostate Images...... 3489 Sophie Riches, Mike Partridge, Geoff S. Payne, Vonnie A. Morgan, Nandita M. deSouza

Quantitative Comparison of Methods for Spatial Normalisation of CASL Perfusion MR Images ...... 3490 Stephen J. Wastling, Owen O'Daly, Fernando O. Zelaya, Matthew Howard, David C. Alsop, Ruth L. O'Gorman

A MR Brain Template of Young Children ...... 3491 Zuyao Y. Shan

Image Registration of Whole-Body Mouse MRI...... 3492 X Josette Chen, Satheesh Maheswaran, Daniel Rueckert, R Mark Henkelman

Diffeomorphic Normalization Via Constant Acceleration Field ...... 3493 Yung-Chin Hsu, Ching-Han Hsu, Wen-Yih Isaac Tseng

Registration Methodology of Histology with in Vivo 3T MRI for Human Prostate...... 3494 Hyunjin Park, Morand Piert, Bing Ma, Charles Meyer

3D Phase Unwrapping Based on Expansion in Chebyshev Polynomials ...... 3495 Jason Langley, Qun Zhao

Effects of Distortion and Inhomogeneity Correction on Brain Morphometry with 3T MRI ...... 3496 Osamu Abe, Hidemasa Takao, Hiroyuki Kabasawa, Hidenori Yamasue, Masami Goto, Wataru Gonoi, Harushi Mori, Akira Kunimatsu, Yoshitaka Masutani, Kiyoto Kasai, Kuni Ohtomo

New Thresholding Correction Methods on BOLD fMRI for Interpreting Brain Function ...... 3497 Han-Su Baek, Gwang-Woo Jeong, Tae-Hoon Kim, Hyeong-Jung Kim, Thirunavukkarasu Sundaram,Gwang-Won Kim, Tae-Jin Park

Evalutation of Methods for Removal for Background Field Inhomogenities in Susceptibility Weighted Phase Imaging ...... 3498 Ferdinand Schweser, Andreas Deistung, Berengar Wendel Lehr, Juergen R. Reichenbach

Evaluating Reliability of Performance Metrics for Bias Field Correction in MR Brain Images...... 3499 Vitali Zagorodnov, Zin Yan Chua, Weili Zheng

Distortion Correction for Echo Planar MR Imaging Using the Regularized Inverse Solution of the Point Spread Function (PSF) Map ©...... 3500 Yu Cai, Qingwei Liu, Hongyu An, Weili Lin, Craig Hamilton

Fast and Automatic Quantification of Cardiac Perfusion MRI...... 3501 Andreas Weng, Christian Oliver Ritter, Joachim Lotz, Meinrad Joachim Beer, Dietbert Hahn, Herbert Köstler

Orientation Dependence of Grey/white Matter Contrast in Ultra High Fields...... 3502 Andreas Schäfer, Richard Bowtell, Robert Turner

Systematic Comparison of Quantitative T1 Mapping Methods at 7 T High Field ...... 3503 Thomas Trantzschel, Kai Zhong, Oliver Speck

Complex-Valued Voxel Thresholding Increases Image Contrast in SWI...... 3504 Daniel B. Rowe, E. Mark Haacke

Connectivity in Controls and Epilepsy: Demonstration of a Metabolic Network by MRSI...... 3505 Jullie W. Pan, Ruben Kuzniecky, Susan Spencer, Dennis Spencer, Hoby P. Hetherington

Cortical Surface Structure Analysis in Sharks Using Magnetic Resonance Imaging (MRI) ...... 3506 Kara E. Yopak, Greg T. Balls, Lawrence R. Frank

Computer-Aided Detection (CAD) for Breast MRI at 3.0T: A Comparison Between Four Observers with Different Levels of Experience...... 3507 Carla Meeuwis, S M. van de Ven, G Stapper, A M. Fernandez Gallardo, M A. van den Bosch, , W P. Mali, W B. Veldhuis

Prediction of Malignant Breast Lesions from MRI Features: A Comparison of Artificial Neural Network and Logistic Regression Techniques ...... 3508 Ke Nie, Christine E. McLaren, Wen-Pin Chen, Jeon-Hor Chen, Orhan Nalcioglu, Min-Ying Lydia Su

Comparison of Normalized DTI Analytical Methods: Detection Powers of Voxel-Based Analysis and Sub-Atlas Based Analysis ...... 3509 Koji Sakai, Susumu Mori, Kenichi Oishi, Andreia Faria

Selective Evaluation of Fast MRI Reconstruction Artifacts Using Case-PDM ...... 3510 Jun Miao, David L. Wilson,

Comparison of Methods for the Measurement of Cardiac Function in Rats ...... 3511 Johannes Riegler, Anthony Niel Price, Kenneth King Cheung, Jon Orlando Cleary, Mark Francies Lythgoe

Calculation of the Magnetic Susceptibility from Susceptibility Weighted Phase Images ...... 3512 Andreas Deistung, Berengar W. Lehr, Ferdinand Schweser, Jürgen R. Reichenbach

Magnetic Resonance Elastography of Polymer Gel Dosimetry Phantoms ...... 3513 Yogesh Kannan Mariappan, Silvio L. Vieira, Julianna P. Fernandes, Antonio Adilton Carneiro, Mostafa Fatemi, Richard L. Ehman

Model Regularization with Blind Deconvolution...... 3514 Jacob U. Fluckiger, Matthias C. Schabel, Edward VR DiBella

Wireless Local Coil Signal Transmission Using a Parametric Upconverter ...... 3515 Sebastian Martius, Oliver Heid, Markus Vester, Stephan Biber, Juergen Nistler

Multi-Purpose, Multi-Nuclei, Multi-Channel Data Acquisition System ...... 3516 Pekka Sipilä, Rolf Schulte, Gerhard Wachutka, Florian Wiesinger

Using On-Board Microprocessors to Control a Wireless MR Receiver Array ...... 3517 Matthew J. Riffe, Jeremiah A. Heilman, Natalia Gudino, Mark A. Griswold

Modeling Low Magnetic Moment PIN Diodes for MR Scanner Applications ...... 3518 Robert Caverly, William E. Doherty, Ronald Watkins

Validation of Noise Figure Measurements by Means of MR Imaging ...... 3519 Jurek A. Nordmeyer-Massner, Klaas P. Pruessmann

A Probe for Electric Properties of Phantom Liquids ...... 3520 Christian Findeklee, Gesa Lilith Franke, Ulrich Katscher

Theory of Radiation Damping Without the FIlling Factor...... 3521 James Tropp

Large Field-Of-View in Vivo Imaging Using Traveling Waves on a Whole Body 7 Tesla Scanner ...... 3522 Nadine Smith, Kristina Haines, Maarten Versluis, Andrew Webb

Traveling Wave Imaging of the Human Head at 7 Tesla: Assessment of SNR, Homogeneity and B1+ Efficiency ...... 3523 Graham Wiggins, Bei Zhang, Qi Duan, Daniel K. Sodickson

Reciprocity Relations in Travelling Wave MRI...... 3524 David Otto Brunner, Klaas Paul Pruessmann

Optimizing Traveling Wave RF Excitation for in Vivo Use ...... 3525 Cornelis A.T. van den Berg, Hugo Kroeze, Bart L. van de Bank, Bob van den Bergen, Peter R. Luijten, Jan J.W. Lagendijk, Dennis W.J. Klomp

Local Intensity Shift: A Comparison of Loop and Micro-Strip Receivers at 3.0T ...... 3526 Selaka Bandara Bulumulla, Eric Fiveland, Keith J. Park, Randy O. Giaquinto, Graeme C. McKinnon, Christopher J. Hardy

A Microstrip Volume Coil with Easy Access for Wrist Imaging at 7T ...... 3527 Chunsheng Wang, Alex Pai, Bing Wu, Roland Krug, Sharmila Majumdar, Xiaoliang Zhang

Prostate Imaging at 7T Using Four Stripline Elements and One Amplifier...... 3528 Alexander J. Raaijmakers, Bob van den Bergen, Bart L. van de Bank, Hugo Kroeze, Dennis W. Klomp,Cecilia Possanzini, Paul R. Harvey, Cornelis A. van den Berg

Signal Intensity Profile Comparison of Two Different QD Surface Coils...... 3529 Suk-Min Hong, Kyoung-Nam Kim, Jae-Yong Han, Jung-Hwan Kim, Zang-Hee Cho

Design of a New Dual-Helix Loop Coil for Intravascular MR Imaging...... 3530 Mohammad Mohammadzadeh, Mahmud Shahabadi

Design of a Multi-Segmented Flexible Loop-Gap Resonator for High Sensitivity Imaging of the Human Wrist at 7 Tesla ...... 3531 Andrew Webb, Maarten Versluis

B1+ and SNR Optimization of High Field RF Coils Through Offsetting of Transmit and Receive Elements ...... 3532 Graham Wiggins, Qi Duan, Riccardo Lattanzi, Daniel K. Sodickson

A Modular MRI Probe Design for Large Rodent Neuroimaging at 21.1 T (900 MHz) ...... 3533 Peter L. Gor'kov, Chunqi Qian, Barbara L. Beck, M.D. Clark, Ihssan S. Masad, Victor D. Schepkin,Samuel C. Grant, William W. Brey

Design and Implementation of a Quadrature RF Volume Coil for in Vivo Brain Imaging of a Monkey in a Stereotaxic Device...... 3534 Colin A. Roopnariane, Patti A. Miller, Bu Sik Park, Lukas Ansel, Sukhoon Oh, Christopher Lieu, Thyagarajan Subramanian, Mohammed Reza Tofighi, Christopher M. Collins

How Much Does Coil Geometry Matter in High-Field Brain Imaging? a Numerical Study with High-Fidelity Coil Modeling...... 3535 Shumin Wang, Jeff Duyn

Dedicated Endoluminal Coil for Anal Sphincter MR Imaging ...... 3536 Olivier Beuf, Franck Jaillon, Mircea Armenean, Hervé Saint-Jalmes, Frank Pilleul

Experiments and Quantification of Lumped Elements Volume Coil for B1+Excitation at 7T ...... 3537 Kyoung-Nam Kim, Suk-Min Hong, Jae-Yong Han, Hyo Woon Yoon, Jun-Young Chung, Jung-Hwan Kim, Zang-Hee Cho

Common Mode Volume Coil Design for in Vivo MR Imaging at 7T ...... 3538 Zhentian Xie, Duan Xu, Daniel Vigneron, Xiaoliang Zhang

Design of Actively Decoupled Implant Coil System with Improved B1 Homogeneity in Rat Spinal Cord...... 3539 Andrew C.H. Yung, Nathan Wolfe, Tinny Lai, Lynn Tsai, Jenny C.H. Tso, Jie Liu, Piotr Kozlowski

MRI with a Rapidly Rotating RF Coil ...... 3540 Adnan Trakic, Ewald Weber, Bing Keong Li, Hua Wang, Stuart Crozier

Remote Detection Coil Setup for Imaging High Velocity Flow Dynamics of Gases with Hyperpolarized 3Helium...... 3541 Florian Martin Meise, Elena Knaub, Julien Rivoire, Maxim Terekhov, Alexander-Wigbert K. Scholz, Ursula A. Wolf, Wolfgang G. Schreiber

Micro-MR Coil Construction by Combining Metal-On-Glass Inkjetting and MEMS Techniques...... 3542 Dario Mager, Vlad Badilita, Ute Loeffelman, Patrick James Smith, Jan Gerrit Korvink

Micro Helmholtz Coil Pair Towards Cellular Applications ...... 3543 Kai Kratt, Vlad Badilita, Tobias Burger, Jan G. Korvink, Ulrike Wallrabe

Development of Superconducting RF Probe for Low Field Orthopedic Imaging...... 3544 Jack Liu, S. Y. Chong, S. M. Yeung, Q. Y. Ma

Dual-Frequency Coil Design Using Common Mode and Differential Mode (CMDM) Technique for 1H/13C MRSI at 7T ...... 3545 Zhentian Xie, Daniel Vigneron, Xiaoliang Zhang

A Practical Multi-Tuned Birdcage Resonator for MRI/MRS at 7T...... 3546 Chunsheng Wang, Bing Wu, Dan Vigneron, Xiaoliang Zhang

19F/1H Double-Tuned RF Coil for 19F-Labeled Drug Distribution Monitoring at 7 T ...... 3547 Yosuke Otake, Yoshihisa Soutome, Koji Hirata, Yoshitaka Bito

A Dedicated 4-Channel RF Receiving Array for Orthodontic Examinations ...... 3548 Markus Düring, Daniel Gareis, Olga Tymofiyeva, Marcos Lopez, Peter Jakob

A Multi-Purpose Cardiac and Abdominal Surface Coil with Up to 36 Elements ...... 3549 Karsten Jahns, Markus Adriany, Stephan Biber, Wilhelm Horger, Sonia Nielles-Vallespin, Michaela Schmidt, Hubertus Fischer

A 16 Channel Phased Array Coil Optimized for Diagnostic Breast Imaging...... 3550 Tobias Wichmann, Rainer Kurth, Christian Geppert, Alexander Weisser, Florian Odoj, Peter M. Jakob, Titus Lanz

Eight Channel Custom Breast Coil for Parallel Imaging in Two Directions...... 3551 Anderson Nnewihe, Thomas Grafendorfer, Bruce Daniel, Paul Calderon, Marcus Alley, Brian Hargreaves

A Flexible Highly Configurable 16 Channel Array Coil for Fetal Imaging ...... 3552 David Herlihy, David J. Larkman, Joanna Allsop, Mary Rutherford, Jo V. Hajnal

Flexible 8 Channel Receive Only Array for Elbow Imaging ...... 3553 Robert Ladkani, Tim Farina

16 Channel, Bell Shaped Surface Coil for Knee Imaging ...... 3554 Modhurin Banerjee Snyder, Pei H. Chan, Madwesha Rao, Fraser Robb

A Novel Inter-Resonant Coil Decoupling Technique for Parallel Imaging ...... 3555 Raghad Aal-Braij, Andreas Peter, Laura Del Tin, Jan G. Korvink

A Closed-Form Expression for Ultimate Intrinsic Signal-To-Noise Ratio in MRI ...... 3556 Emre Kopanoglu, Vakur B. Erturk, Ergin Atalar

OCEAN: Offset Centre-Frequency Encoded Array Network...... 3557 Martyn NJ Paley, Hoon-Sin Cheong

Procedure for RF Coil Array Analysis Using the Method of Moments ...... 3558 Rostislav Lemdiasov, Reinhold Ludwig, Gene Bogdanov

Information Theory in MRI ...... 3559 David Otto Brunner, Jurek A. Nordmeyer-Massner, Klaas Paul Pruessmann

Layout Optimization of a 24-Channel Receive Array for 7.0 Tesla Brain Imaging ...... 3560 Shumin Wang, Jeff Duyn

Field of View Reduction with RF Shield Mesh Sheet ...... 3561 Shin-ichi Urayama, Naozo Sugimoto, Takashi Azuma, Hidenao Fukuyama

Novel Method to Estimate Coil Coupling for Enhanced Tuning and Parallel Image Reconstruction ...... 3562 Liang Liu, Thomas Talavage, Charles Bouman, YunJeong Stickle, Limin Feng, Victor Taracila, Pei H Chan, Fraser Robb

A New Electronically Controllable Tuner System for Precise Noise Figure Measurement...... 3563 Stephan Biber, Sebastian Martius, Klaus Huber

Optimized Coil Design for Parallel Imaging ...... 3564 Walid Elias Kyriakos, Ehud Schmidt, Ferenc A. Jolesz, Robert V. Mulkern

Short Hybrid Micro-Strip Coils...... 3565 Selaka Bandara Bulumulla, Ken W. Rohling, Eric Fiveland, Keith J. Park, Maxine M. Gibeau, Luca Marinelli, Christopher J. Hardy

Modular Preamplifier Design and Application to Animal Imaging at 7 and 11.7T ...... 3566 Stephen J. Dodd, George C. Nascimento, Meng-Chi Hsieh, Hellmut Merkle, Joseph Murphy-Boesch, Jyh-Horng Chen, Alan P. Koretsky, Afonso C. Silva

300 MHz Receive Array Setup for High Resolution in Vitro Studies of Human Brain Tissue ...... 3567 Hellmut Merkle, Peter van Gelderen, Shumin Wang, Bing Yao, Jeff H. Duyn

Evaluation of High Temperature Superconducting (HTS) Coil Performance Gain for 3T Small Animal MR Imaging ...... 3568 Bobo Hu, Chris Randell, Colin Sunderland, Brett Haywood, Paul Glover

Implementation of a Four-Channel Phased-Array Coil for PatLoc Imaging...... 3569 Elmar Fischer, Andreas Peter, Laura Del Tin, Jürgen Hennig, Jan Korvink, Maxim Zaitsev

A Thin-Walled, Cylindrical 4-Channal Receive-Only Coil Array Suitable for PatLoc Imaging at 9.4 T...... 3570 Andreas Peter, Laura Del Tin, Jan G. Korvink

4-Channel Transceive Surface Coil Array for Reduction of EPI-Induced Artifacts Using SENSE and GRAPPA...... 3571 Samuel O. Oduneye, Craig K. Jones, Ravi S. Menon

A 1-Channel Transmit Birdcage and 8-Channel Receive Array for in Vivo Rodent Imaging on a 7 T Human Whole-Body System...... 3572 Stephan Orzada, Stefan Maderwald, Sophia L. Goericke, Nina Parohl, Sabine Begall, Angelica G. Montero, Anika Schinköth, Harald H. Quick, Mark E. Ladd

Development of New Dual Tuned Coil and Array for Multi Nuclear Imaging...... 3573 SeungHoon H. Ha, Lutfi Tugan Muftuler, Orhan Nalcioglu

Design and Evaluation of a 32 Channel Phased Array Coil for Human Lung Imaging Using Hyperpolarized 3He ...... 3574 Florian Martin Meise, Julien Rivoire, Wiggins C. Graham, Boris Keil, Maxim Terekhov, Davide Santoro, Zahir Salhi, Sergei Karpuk, Lawrence L. Wald, Wolfgang G. Schreiber

Design of a Coil System for Hyperpolarized 3He Human Lung Imaging...... 3575 Jian-xiong Wang

Endorectal Combined Surface Array for Prostate Imaging at 7T...... 3576 Gregory J. Metzger, Steen Moeller, Carl J. Snyder, Kamil Ugurbil, Pierre-Francois van de Moortele,Gregor Adriany

7T Transmit Four-Channel Receive Array for High-Resolution MRI of Trabecular Bone in the Distal Tibia...... 3577 Alexander C. Wright, Michael Wald, Tom Connick, Jeremy Magland, Hee Kwon Song, Branimir Vasilic, Rosti Lemdiasov, Reinhold Ludwig, Felix W. Wehrli

7T Human Spine Arrays with Adjustable Inductive Decoupling ...... 3578 Bing Wu, Chunsheng Wang, Roland Krug, Douglas Kelley, Duan Xu, Suchandrima Banerjee, Daniel Vigneron, Sarah Nelson, Sharmila Majumder, Xiaoliang Zhang

A New Simple High Field Transmit Coil Design: Open Cavity Resonator...... 3579 Ozlem Ipek, Bob van den Bergen, J. J. W. Lagendijk, Cornelis A T van den Berg

A Flexible 8-Channel Transmit/receive Body Coil for 7 T Human Imaging...... 3580 Stephan Orzada, Harald H. Quick, Mark E. Ladd, Achim Bahr, Thomas Bolz, Pedram Yazdanbakhsh, Klaus Solbach, Andreas K. Bitz

A Hemispherical 8 Independent Element Probe Suitable for Transmit SENSE at 7T ...... 3581 Daniel James Lee, Paul M. Glover

UHF Propagation in a Partially Filled Short Cylindrical Waveguide...... 3582 Jennifer A. Black, James E. Richie

Variable Geometry Elliptical Transceiver Phased Array for Imaging of the Human Brain at 7 T ...... 3583 Nikolai I. Avdievich, Jullie W. Pan, Andrey M. Kuznetsov, Hoby P. Hetherington

32 Channel Coil Array for Parallel RF Transmission...... 3584 Yudong Zhu, Randy Giaquinto, Xu Chu, Eric Fiveland, Xing Yang, Tingting Song, Keith Park, Joseph Piel

An Inverse Method for the Design of RF Array Coils with a Sparse Structure and Its Application for Breast Imaging ...... 3585 Yu Li, Feng Liu, Ewald Weber, Bing Keong Li, Stuart Crozier

A 16 Channel T/R Open-Faced Head Array for Humans at 9.4T ...... 3586 Gregor Adriany, Dinesh Deelchand, Pierre-Gil Henry, Jinfeng Tian, John Thomas Vaughan, Kamil Ugurbil, Pierre-Francois van de Moortele

7T Breast Imaging with a 2-Channel Bilateral Loop Design...... 3587 Leighton Lloyd Warmington, Gregor Adriany, Carl Snyder, Edward J. Auerbach, Patrick J. Bolan

An Eight-Channel Transmit/Receive RF Array for Imaging the Carotid Arteries at 7 Tesla ...... 3588 Oliver Kraff, Andreas K. Bitz, Stephan Orzada, Stefan Maderwald, Stefan Kruszona, Lena C. Schaefer, Janine Y S Grootfaam, Mark E. Ladd, Harald H. Quick

A Concentrically Shielded Transceive Array Coil Optimized for B1+Inhomogeneity Correction at 7T...... 3589 Vijayanand Alagappan, Kawin Setsompop, Ulrich Fontius, Franz Schmitt, Elfar Adalsteinsson,Lawrence Leroy Wald

Multi-Channel Transceive Coil for Improved Knee Imaging at 7T ...... 3590 Can Akgun, Lance DelaBarre, Ute Goerke, Carl J. Snyder, Jutta Ellerman, Kamil Ugurbil, John Thomas Vaughan

8-Channel Transmit/receive Head Coil for 7 T Human Imaging Using Intrinsically Decoupled Strip Line Elements with Meanders...... 3591 Stephan Orzada, Oliver Kraff, Lena C. Schäfer, Irina Brote, Achim Bahr, Thomas Bolz, Stefan Maderwald, Mark E. Ladd, Andreas K. Bitz

An Adaptable 8-Channel Transmit Array Head Coil for Parallel Transmit and B0 Mitigation at 3T...... 3592 Vijayanand Alagappan, Weiran Deng, Cungeng Yang, Andrew Victor Stenger, Lawrence Leroy Wald

Parallel Transceive Array for 9.4 T Animal Studies ...... 3593 Christopher J. Wargo, Malcolm J. Avison, John C. Gore

Volume 7

A New Decoupling Method for Coil Elements on a Cylinder Surface...... 3594 Xuelian Lu, Yao Xing, Haining Wang,Jianmin Wang

Single-Feed Quadrature Coils as Transceiver Array Elements for Improved SNR and Transmit Efficiency...... 3595 Xiaoliang Zhang, Chunsheng Wang

Geometrically Decoupled Phased Array Coils for Mouse Imaging ...... 3596 Sahil P. Bhatia, Yiping Guan, Fraser Robb, Mary P. McDougall

A Reliable Method for Calculating RF Coil Performance...... 3597 Mikhail Kozlov, Christoph Leuze, Robert Turner

A Fully Digital RF Pulse Generator Designed for Multiple Transmission Channels ...... 3598 André Kuehne, Werner Hoffmann, Frank Seifert

Planar Butler Matrix Technology for 7 Tesla MRI...... 3599 Pedram Yazdanbakhsh, Andreas Bitz, Stephan Orzada, Oliver Kraff, Mark E. Ladd, Klaus Solbach

Development of a 64 Channel Parallel Transmit System...... 3600 Neal Anthony Hollingsworth, Ke Feng, Chieh-Wei Chang, Steve M. Wright, Mary Preston McDougall

Highly Distributed RF Transmission with a 32-Channel Parallel Transmit System...... 3601 Yudong Zhu, Xu Chu, Chengtao Cao, Eric Fiveland, Randy Giaquinto, Tingting Song, Xing Yang, Cheng Zhang, Joseph Piel, Keith Park

An Inexpensive, Scalable Vector Modulator and Application to 2D RF Pulses...... 3602 Ke Feng, Neal Anthony Hollingsworth, John Carl Bosshard, Douglas C. Noll, Steven M. Wright

PC Controlled 8-Transmit Channel Circuit with Independent Phase and Amplitude Control for 7T ...... 3603 Yong Pang, Zhentian Xie, Bing Wu, Chunsheng Wang, Daniel Vigneron, Sarah Nelson, Xiaoliang Zhang

Imaging Study with Ultra-Low Output Impedance RF Power Amplifiers...... 3604 Xu Chu, Tingting Song, Xing Yang, Eric W. Fiveland, Yudong Zhu

A Versatile In-Line Sensor for Power Monitoring and Calibration of Transmit Arrays ...... 3605 Pascal Pawel Stang, John Mark Pauly, Greig C. Scott

A Load Pull/Hot S22 Analyzer for Transmit Array Amplifiers...... 3606 Greig Scott, Pascal Stang, Adam Kerr, John Pauly

Design of MOSFET Matching Networks Without Inductors...... 3607 Ke Feng, Neal Anthony Hollingsworth, Mary Preston McDougall, Steven M. Wright

A Four Channel Transmission Array Based on CMCD Amplifier ...... 3608 Jeremiah Aaron Heilman, Natalia Gudino, Matthew Joseph Riffe, Philipp Liu, Mark A. Griswold

Evaluation of Spatial Distortion in the 7.0T MRI for Clinical Use Using New 3D Mesh Phantom ...... 3609 Young-Don Son, Hang-Keun Kim, Sung-Tae Kim, Nam-Beom Kim, Young-Bo Kim, Zang-Hee Cho

Maximum Sound Pressure Levels at 7 Tesla – What’s All This Fuss About?...... 3610 Sebastian Schmitter, Marco Mueller, Wolfhard Semmler, Michael Bock

RF Heating of Pacemaker Leads: Do Open MR Systems Perform Better Than Close Bore Systems?...... 3611 Roger Luechinger, Volkert A. Zeijlemaker, B Mengiardi, Peter Boesiger

Efficacy of Diphenhydramine in the Prevention of Vertigo and Nausea at 7 Tesla...... 3612 Markus Thormann, Jens Ricke, Astrid Wollrab, Daniela Adolf, Oliver Speck

TMS/fMRI: Risk Assessment at 4T...... 3613 Paolo Ferrari, Jorge Jovicich, Jens Volkmar Schwarzbach, Marco Sandrini, Simon Robinson

The Correct Method for Numerical Calculation of Induced Electric Fields for Rotational Movements in Static Magnetic Fields...... 3614 Paul Glover, Clemente Cobos Sanchez, Henry Power, Richard Bowtell

Safety Evaluation of a 3T Neonate Head Coil Using Numerical Calculations ...... 3615 Bu Sik Park, Ravi Srinivasan, Christopher M. Collins

Measurement of Occupational Exposure to RF and Gradient Fields in an Open 1T MR System ...... 3616 Myles Capstick, Sven Kuehn, Michael Oberle, Rebecca Quest, Annie Papadaki, Marc Rea, Donald McRobbie, Niels Kuster

RF Safety and Thermal Charecterists of Porcine Heads After Euthanasia ...... 3617 Devashish Shrivastava, Timothy Hanson, Jeramy Kulesa, J. Thomas Vaughan

Towards Direct B1 Based Local SAR Estimation...... 3618 Martijn Anton Hendrik Cloos, Giorgio Bonmassar

Field Superposition Method for RF Coil Design...... 3619 Jan Paska, Juerg Froehlich, David O. Brunner, Klaas P. Pruessmann, Ruediger Vahldieck

Fast MR Simulations with JEMRIS 2.1 - Disclosing the Secrets of MRI Sequence Development...... 3620 Kaveh Vahedipour, N. Jon Shah, Tony Stöcker

Field and S-Parameter Simulation of Arbitrary Antenna Structure with Variable Lumped Elements ...... 3621 Rongxing Zhang, Yao Xing, Juergen Nistler, Jianmin Wang

Efficient Optimal-Numerical-Analytical Computation: Segmented Spiral Coil at High Field ...... 3622 Xin Chen, Xingxian Shou, Yong Wu, Minhua Zhu, Mark A. Griswold, Hiroyuki Fujita, Robert W. Brown

Modeling Occupational Exposure to RF and Gradient Fields Associated with an Interventional Procedure in an Open 1 T MR System ...... 3623 Yan Li, Jeff Hand, Andreas Christ, Eugenia Cabot, Donald McRobbie, Myles Capstick, Michael Oberle, Niels Kuster

Direct Calculation of Tissue Electrical Parameters from B1 Maps...... 3624 Selaka B. Bulumulla, Teck Beng Yeo, Yudong Zhu

Effect of Model and Voxel Size on the Simulated Gradient Induced Electric Fields ...... 3625 Rebecca Emily Feldman, William Handler, Blaine Alexander Chronik

A Study of the Relationship Between B1-Field Uniformity, Body Aspect Ratio and SAR for Whole-Body RF Shimming at 3.0T...... 3626 Zhiyong Zhai, Michael Morich, Gordon DeMeester, Paul R. Harvey

Comparison of Elements Geometries in B1 Shimming with a 16-Channel Whole Body Transmit Array at 3T ...... 3627 Yeun Chul Ryu, Bu Sik Park, Sukhoon Oh, Silvie Garret, Christopher M. Collins

Computer Assisted Magnetic Resonance Imaging (MRI) Simulation on the Basis of MR System Components...... 3628 Silke Maria Lechner, Bruce Amm, Hans-Joachim Bungartz, Thomas K. Foo, Mika W. Vogel

Development of Digital Wireless Transceiver for a MRI Coil with Clock Synchronization ...... 3629 Takahiro Sekiguchi, Koji Akita, Toshiyuki Nakanishi, Sojuro Kato, Kohei Adachi, Kazuya Okamoto

MR Image Noise and a Direct Sampling ADC...... 3630 Graeme McKinnon

Implementation of High Frequency MRI Coil Arrays Entirely Based on Design-By-Simulation ...... 3631 Laura Del Tin, Andreas Peter, Jan G. Korvink

RF B1 Field Localization at 9.4T Through Convex Optimization with an Iterative Method...... 3632 Hyoungsuk Yoo, Anand Gopinath, J. Thomas Vaughan

Optimization of Encoding Fields for PatLoc Imaging...... 3633 Anna M. Welz, Hartmut Schmidt, Jürgen Hennig, Maxim Zaitsev

How Reliable Are Computer Simulations for RF Power Deposition? An Experimental Verification of Numerical Simulations...... 3634 Shizhe Li, Shumin Wang, Jun Shen

+ Evaluation of B1 and E Field of RF Resonator with High Dielectric Insert ...... 3635 Chunsheng Wang, Xiaoliang Zhang

Gradient Coil Induced Eddy Current Computation Using the Boundary Elements Method ...... 3636 Shmaryu Shvartsman, John L. Patrick, James F. Dampsey, K. M. Prasad

Design Strategy for Shielded Open MRI Magnets...... 3637 Franco E. Bertora, Elisa Molinari, Andrea Viale

Comparison Between CCMI and CAHM for Design Shielded Gradient Coils for MRI ...... 3638 Silvia Sandra Hidalgo, Carl Gadzinski, Brian Rutt

Evaluation of Two Shielding Strategies ...... 3639 Hector Sanchez, Michael Poole, Feng Liu, Stuart Crozier

A Novel Gradient Design: Simultaneous Generation of Fast Switchable Linear and High Order Field Gradient for MR Imaging ...... 3640 Stefan Wintzheimer, Florian Fidler, Michael Ledwig, Toni Drießle, Daniel Gensler, Peter Michael Jakob

Theoretical Design of 3D Gradient Coils ...... 3641 Peter Thomas While, Larry K. Forbes, Stuart Crozier

High Order Stream Function Method to Automatically Design MRI Gradient Coil...... 3642 Feng Jia, Zhenyu Liu, Anna M. Welz, Maxim Zaitsev, Jan G. Korvink, Jürgen Hennig

Adaptive Method for Gradient Coil Design ...... 3643 Shmaryu M. Shvartsman, Xin Chen, Tanvir N. Baig, Minhua Zhu, John L. Patrick, James F. Dempsey, Robert W. Brown

An Inverse Design Method for 3D Toroidal Gradient Coils...... 3644 Peter Thomas While, Larry K. Forbes, Stuart Crozier

A Novel Cradle-Shaped Gradient Coil for High-Field MRI...... 3645 Kyle M. Gilbert, Joseph S. Gati, Ravi S. Menon

Double Region Local Bi-Planar Gradient Array Design for Breast Imaging...... 3646 Sung Man Moon, Kenneth Craig Goodrich, J. Rock Hadley, Dennis L. Parker

MR Microscopy Using Uniplanar Magnetic Field Gradients...... 3647 Lin Zhao, Andrey V. Demyanenko, Shuyi Nie, J. Michael Tyszka

Forces and Torques on Small Animal Insert Gradient Coils ...... 3648 Matthew Aloysius McAlpine, William Handler, Blaine Chronik

Simple Method for MR Gradient System Characterization...... 3649 Nii Okai Addy, Hochong H. Wu, Dwight G. Nishimura

A Four Mirror-Current Planes Model for the Gradient Field Enhancement in a Permanent Magnet ...... 3650 Shinya Handa, Katsumi Kose, Tomoyuki Haishi

EPI Imaging with a Dual Gradient System ...... 3651 K Craig Goodrich, Seong-Eun Kim, Sung Man Moon, J. Rock Hadley, J Ulrich Fontius, Franz Schmitt, Dennis L. Parker

Overcoming Coil Phase Effects in Highly Accelerated Imaging with a Dedicated Fourth Gradient Channel...... 3652 John Carl Bosshard, Mary Preston McDougall, Steven Michael Wright,

Non-Linear Encoding Gradient Optimization for O-Space Imaging with a Microstrip Coil Array...... 3653 Lick-Kong Tam, Jason Stockmann, Pelin Aksit Ciris, Robert Todd Constable

Development of a Non-Shielded PatLoc Gradient Insert for Human Head Imaging...... 3654 Anna M. Welz, Maxim Zaitsev, Feng Jia, Zhenyu Liu, Jan Korvink, Hartmut Schmidt, Heinrich Lehr,Hans Post, Andrew Dewney, Jürgen Hennig

Comparison of Cylindrical and Elliptical Geometry Gradient Coils ...... 3655 Sung Man Moon, J. Rock Hadley, Kenneth Craig Goodrich, Dennis L. Parker

Prediction of Susceptibility-Induced Artefacts for Prospective Motion Correction...... 3656 Rainer Boegle, Julian Maclaren, Maxim Zaitsev

2 Susceptibility-Matched H2O NMR Probes for Magnetic Field Monitoring ...... 3657 Pekka Sipilä, Sebastian Greding, Gerhard Wachutka, Florian Wiesinger

Can a Generalized Passive Shimming Array Improve Field Homogeneity for Human Brain Imaging at 7 T? ...... 3658 Dennis F R Heijtel, Peter van Gelderen, Jeff H. Duyn, Jacco A. de Zwart

Refocusing Method for Mapping Imaging Gradients with High SNR ...... 3659 Jason Peter Stockmann, Robert Todd Constable

Whole Brain Field Homogenization with Localized Electrical Coils...... 3660 Christoph Juchem, Terence W. Nixon, Mark Abildgaard, Scott McIntyre, Douglas L. Rothman, Robin A. de Graaf

Magnetic Field Homogenization of the Human Prefrontal Cortex with a Set of Localized Electrical Coils ...... 3661 Christoph Juchem, Terence W. Nixon, Scott McIntyre, Douglas L. Rothman, Robin A. de Graaf

First-To-Fourth Order Spherical Harmonics Shimming with a Grid of Circular Electrical Coils...... 3662 Christoph Juchem, Douglas L. Rothman, Robin A. de Graaf

Design of a High Power Customized Shim Set Insert for in Vivo Spectroscopy of Deep Brain Structures in Humans at 4T ...... 3663 Parisa Hudson, L. Martyn Klassen, William Bradfield Handler, Blaine Alexander Chronik

Shielding Requirements for a Complete 3rd Order Shim Set for a 31cm Bore 9.4T System...... 3664 Dustin Wesley Haw, Blaine Alexander Chronik

An Experimental Study of the Feasibility of Simultaneous MRI and Spect Imaging ...... 3665 Mark J. Hamamura, Seung Hoon Ha, Werner W. Roeck, Orhan Nalcioglu, Douglass J. Wagenaar, Dirk Meier, Bradley E. Patt

Effective RF Shielding with Carbon Fiber Composites for Simultaneous PET/MRI ...... 3666 Bo Joseph Peng, Yibao Wu, Simon R. Cherry, Jeffrey Walton

Multifunctional PET/MR Imaging in Small Animal Models...... 3667 Hans F. Wehrl, Martin S. Judenhofer, Petros Martirosian, Florian Maier, Gerald Reischl, Fritz Schick, Bernd J. Pichler

Investigation of Detector Collimator Effects for Dual Modality MR –Nuclear Imaging...... 3668 Seung Hoon Ha, Mark J. Hamamura, Werner W. Roeck, Orhan Nalcioglu, Douglass J. Wagenaar, Dirk Meier, Bradley E. Patt

A Stationary SPECT System for Simultaneous MRI/SPECT Dual-Modality Pre-Clinical Imaging ...... 3669 Douglas Jay Wagenaar, Dirk Meier, Orhan Nalciolgu, L. Tugan Muftuler, Yuchuan Wang, Benjamin Ming-Wa Tsui, Bradley Earl Patt

Design of a Docking PET and Field-Cycled MRI System for Small Animal Imaging...... 3670 Geron Andre Bindseil, Timothy J. Scholl, William B. Handler, Blaine A. Chronik

MRI Attenuated Whole Body PET Reconstruction: An in Vivo Study Using Animal Subjects ...... 3671 Jeffrey Steinberg, Guang Jia, Steffen Sammet, Jun Zhang, Nathan Hall, Michael V. Knopp

Precise Co-Registration of SPECT and MRI for Small Animal Imaging Using a Common Animal Bed with External References: A Feasibility Study ...... 3672 Masayuki Yamaguchi, Hirofumi Fujii, Kazumasa Inoue, Ryutaro Nakagami, Koutaro Tani, Izumi Ogihara Umeda, Yasuko Mutou, Akira Nabetani, Akira Hirayama, Atsushi Nozaki

Development and Evaluation of a Dedicated Setup for Co-Registered PET/MRI Abdominal Imaging of the Mouse...... 3673 Carole Lartizien, Laurence Canaple, Olivier Beuf

Mobile MR: A Battery Driven Broadband MRI System for Portable Magnets Up to 3T ...... 3674 Michael Ledwig, Toni Michael Drießle, Stefan Wintzheimer, Daniel Gensler, Peter Michael Jakob, Florian Fidler

System for Optimal Stress During Clinical Cardiac MRS ...... 3675 Hee-Won Kim, Karam Souibri, Gerald M. Pohost

A Novel Design for a 1 Tesla Magnet for Mobile MR ...... 3676 Michael Ledwig, Florian Fidler, Toni Drießle, Stefan Wintzheimer, Daniel Gensler, Peter Michael Jakob

Development of a Compact MRI System for a Low Temperature (-5 Degree) Room...... 3677 Satoru Adachi, Toshihiro Ozeki, Shinya Handa, Ryosuke Shigeki, Katsumi Kose, Tomoyuki Haishi

Development of a Shield-Room Free Compact MRI System with a Highly Homogeneous RF Coil for Bone Density Measurements at the Calcaneus...... 3678 Kazuya Taniguchi, Shinya Handa, Katsumi Kose

RF and Gradient Coils for an Elliptical Surface NMR Device ...... 3679 Manola Ciarrocchi, Angelo Galante, Piero Sebastiani, Maria Alfonsetti, Marcello Alecci, Antonello Sotgiu

Numerical Evaluation of Induced Field by Body-Motion Around High Field MRI Magnets: A Case Study with an Implanted Pacemaker ...... 3680 Hua Wang, Feng Liu, Bing Keong Li, Adnan Trakic, Stuart Crozier

Impedance Method for Calculation of Induced Voltage on Implanted Cardiac Leads Due to MRI Gradient Magnetic Fields...... 3681 Jonathan Edmonson, Rungkiet Kamondetdacha, John Nyenhuis, Ben Herberg, Dave Manahan

Average SAR Constrained Local RF Shimming...... 3682 Yigitcan Eryaman, Celal Alp Tunc, Pierre Francois van de Moortele, Kamil Ugurbil, Ergin Atalar

Numerical Investigation Into Effects of a Receive Array on SAR in MRI ...... 3683 Zhangwei Wang, Jason Jin, Christopher M. Collins, Shuren Zhao, Sukhoon Oh, Qing X. Yang, Fraser J. Robb

MR Safety of Implants: Numerical Assessment of SAR Distribution at Design- Simplified Stents of Different Lengths Placed Inside a Virtual Phantom Model Investigated at an MR Frequency of 63.9 MHz...... 3684 Mark Pawlenka, Gregor Schaefers

Comparative Analyses of MR-Induced Distal Heating in Novel Filtered Cardiac Pacing Leads Using Two Geometric Configurations ...... 3685 Frank G. Shellock, Holly Moschiano, Robert S. Johnson, Robert Stevenson, Scott Brainard, Sam Ye, Warren Dabney

Changes in RF Transmit Gain Before and After DBS Lead Placement in 36 Consecutive Patients ...... 3686 Matt A. Bernstein, Heidi A. Ward, Kiaran P. McGee, Joel P. Felmlee, Vicki L. Knudsen, Krzysztof R. Gorny, John Huston III, Kendall H. Lee

Safety Testing of Performing MRI Scans with Implanted Soletra Pulse Generator at 3 Tesla...... 3687 Pallab K. Bhattacharyya, Ken Baker, Micheal Phillips, Mark Lowe

Comparison of Targeting Accuracy with Conventional and MR Guided Deep Brain Stimulator Implantation ...... 3688 Alastair Martin, Paul Larson, Philip Starr

Practical Aspects of MR Imaging in the Presence of Conductive Guide Wires ...... 3689 Natalie Tong, Andriy Shmatukha, Peter Asmah, Jeff Stainsby

Current Challenges for Creating a Wireless MR-Compatible Intracranial Pressure Monitor ...... 3690 Sukhoon Oh, Usmah Kawoos, Mohammad-Reza Tofighi, Arye Rosen, Christopher M. Collins

The Clinical Impact of 1.5T MRI in Patients with a Permanently Implanted Pacemaker: A Necessary Procedure for Indicated Cases...... 3691 Gary Michael Miller, Norbert G. Campeau, Win-Kuang Shen, Joel P. Felmlee, Robert E. Watson

Evaluation of the Forces Acting on a Highly Ferromagnetic Orthopaedic Implant at 1.5T and 3T ...... 3692 Christie McComb, Barrie Condon, David Allan

Dedicated MR ECG Amplifier...... 3693 Lingchuan Zhou, Mohsen Ayachi, Julien Oster, Roger Abächerli, Odille Fokapu, Michel Kraemer,Johann-Jakob Schmid, Jean- Philippe Blondé, Jacques Felblinger

The Effect of Longitudinal Magnetic Resonance Imaging on the Quality of Neurophysiological Recordings Using Implanted Micro-Wire Electrodes...... 3694 Kunal Paralikar, Thomas Neuberger, Joy Matsui, Alistair Barber, Ryan Clement, Andrew Webb

A CLT1 Peptide Targeted Nanoglobular Contrast Agent for Cancer Molecular Imaging with MRI ...... 3695 Mingqian Tan, Xueming Wu, Furong Ye, Eun-Kee Jeong, Zheng-Rong Lu

In Vivo Targeting of ανβ3-Specific Dual-Modality Micellar Nanoprobes ...... 3696 Chase W. Kessinger, Osamu Togao, Chalermchai Khemtong, Masaya Takahashi, Jinming Gao

A Boron/Gd/LDL Adduct for Imaging-Guided Neutron Capture Therapy...... 3697 Simonetta Geninatti, Diego Alberti, Antonio Coppino, Ibolya Szabo, Annamaria Deagostino, Paolo Venturello, Silvio Aime

Gd(III)-Based Probes for MR Imaging of Exofacial Protein Thiols...... 3698 Giuseppe Digilio, Valeria Menchise, Valeria Catanzaro, Franco Fedeli, Roberta Napolitano, Concetta Gringeri, Eliana Gianolio, Silvio Aime

In Vivo MR Imaging of Renal Ischemia Reperfusion Injury in Mice Using Microparticles of Iron Oxide Targeting VCAM-1 ...... 3699 Jurgen E. Schneider, Asim M. Akhtar, Hannah Barnes, Stephanie Baker, Janet E. Digby, Martina A. McAteer, Kathryn Wood, Robin P. Choudhury

Imaging of Neuroinflammation with an ICAM-1 Specific Paramagnetic and Fluorescent Nanoparticle ...... 3700 Lisette H. Deddens, Matti M. Van Schooneveld, Susanne M A Van der Pol, Rolf Koole, Helga E. De Vries, Willem J M Mulder, Rick M. Dijkhuizen

In Vivo Visualization of Cells Marked with Ultra-Small Gd2O3 Nanoparticles, Using a 1.5 T Clinical System and the Chick Embryo Model...... 3701 Marc-Andre Fortin, Luc Faucher, Andrée-Anne Guay-Bégin, Eric Petitclerc, Yves Gossuin, Annelie Lindström

MR Molecular Imaging of Cerebrovascular Amyloid Deposits...... 3702 Kristi Lynn Hultman, Jessica L. Lack, Thomas M. Wengenack, Geoffry L. Curran, Gregory M. Preboske, Ramakrishnan Muthu, Michael Garwood, Clifford R. Jack Jr, Joseph F. Poduslo

MRI-Contrast Agents for Detection of Bacterial Infection ...... 3703 Ania Warczyk, Anatoliy Popov, Stephen Pickup, Ari Goldberg, E. James Delikatny

Efficient Intracellular Delivery of an MR Imaging Probe by a Novel Cell Penetrating Peptide...... 3704 Joern Engelmann, Deepti Jha, Ritu Mishra, Karl-Heinz Wiesmueller, Kamil Ugurbil

Multimodality Investigation of High Density Lipoprotein Action in Atherosclerosis ...... 3705 Torjus Skajaa, David P. Cormode, Peter Jarzyna, Alessandra Barazza, Edward A. Fisher, Ronald E. Gordon, Zahi A. Fayad, Willem J.M. Mulder

In Vivo Monitoring of Liposomal Encapsulated SiRNA Delivery to Tumours...... 3706 Gavin Kenny, Nazila Kamaly, Tammy Kalber, Andrew D. Miller, Jimmy Bell

Development of Novel Intravascular MRI Contrast Agents Using Gadolinium Chelates...... 3707 Chang-Tong Yang, Krisada Kittigowittana, Bingwen Zheng, Kai-Hsiang Chuang, Roderick W. Bates, Xavier Golay

High T1-Relaxivity Nanoparticles for Target Labeling of Ovarian Cancer...... 3708 Sergey Magnitsky, Anatoliy V. Popov, Chunsheng Li, Jennifer Swails, Stephen Pickup, George Coukos, Jerry D. Glickson

Development of Spontaneously Disassembling Dendrimers as a Platform Technology for PARACEST MRI Contrast Agents ...... 3709 Yuguo Li, Mark D. Pagel

Reconstituted High Density Lipoprotein Nanoparticles for Multimodality Molecular Imaging of Tumors ...... 3710 Wei Chen, Peter Jarzyna, Geralda A.F. von Tilborg, Van Anh Nguyen, Gwendalyn J. Randolph, Edward A. Fisher, Willem J.M. Mulder, Zahi A. Fayad

In Vivo Evaluation of a New Extracellular Gd(III) Complex Endowed with High Relaxivity for Tumor Detection in Mice...... 3711 Alessandro Maiocchi, Fulvio Uggeri, Alessandro Barge, Silvio Aime, Lorenzo Tei

The Gadonanotubes: A New Paradigm in Low-Field MR Imaging ...... 3712 Jeyarama Subramanian Ananta Naryanan, Shingo Matsumoto, James B. Mitchell, Murali C. Krishna,Lon J. Wilson

Swollen Micelles; a Nanoparticulate Platform for the Delivery of Hydrophobic Agents...... 3713 Peter Adalbert Jarzyna, Torjus Skajaa, David P. Cormode, Daniel Samber, Arjan W. Griffioen, Zahi A. Fayad, Willem J M Mulder

New Vanadium-Based Magnetic Resonance Imaging Probes Target Glycolytic Tumors ...... 3714 Devkumar Mustafi, Elizabeth Peng, Sean Foxley, Gregory S. Karczmar, Marta Zamora, John W. Ejnik, Heather Martin

Novel Perfluorocarbon Nanoemulsion for 19F MRI Cell Tracking of Two Cell Populations in Vivo...... 3715 Jelena M. Janjic, Deepak K. Kadayakkara, Lisa K. Pusateri, Eric T. Ahrens

Ferritin Overexpression as a Tool for Detection of Live Cells Transplanted Into Infarcted Heart ...... 3716 Anna Naumova, Hans Reinecke, Kelly Stevens, Jennifer Deem, Vasily Yarnykh, Chun Yuan, Charles Murry

Genetic Manipulation of Ferritin for Enhanced MRI Contrast ...... 3717 Tatjana Holand, Panagiotis G. Kyrtatos, Andrew Lowe, Anthony N. Price, Waseem Qasim, Mark F. Lythgoe

19F MRI of Fibroblasts and Neuroblastoma Cells Labeled with Emulsified Perfluoro-15-Crown-5 Ether...... 3718 Samir Mulla-Osman, Ute Bommerich, Johannes Bernarding

Development of New, More Sensitive MR-Reporter Genes for Stem Cell Tracking and Gene Therapy Imaging ...... 3719 Letterio Salvatore Politi, Sara Pizzi, Anna Cozzi, Mario Amendola, Andrea Falini, Luigi Naldini, Sonia Levi, Alessandra Biffi, Giuseppe Scotti

Potential Application of Hyaluronic Acid in MR Imaging ...... 3720 Wenlian Zhu, Dmitri Artemov

Protein Cages Filled with Gadolium Containing Branched Polymers ...... 3721 Lars Liepold, Joseph Frank, Mark Young, Trevor Douglas

Microfabricated Magnetic Microparticles Enable High Contrast MRI Agents ...... 3722 Gary Zabow, Stephen Dodd, John Moreland, Alan Koretsky

In Vitro Molecular MRI to Determine Contrast Sensitivity of Gd DTPA Slex Binding to P Selectin...... 3723 Jessica Hung King Sang, Ursula Tuor, Robert Muller, Tad Foniok, Philip Barber

SPIO-Labeled Cells as an Ffective Vehicle for Tracking GFP Gene Marker with MRI ...... 3724 Zhuoli Zhang, Nicole Mascheri, Rohan Dharmakumar, Zhaoyang Fan, Shengyong Wu, Debiao Li, Mark Tengowski

A Novel Iron Oxide Contrast Agent: Nano in Size and Functioning as Micron-Sized Particles...... 3725 Haosen Zhang, Chih-Lung Chen, Wen-Yuan Hsieh, Hsiu-Hua Huang, Yi-Shan Lin, Hsin-Hsin Shen, Mu-Jen Young, Wei-Lin Yu, Ying-Ting Huang, Qing Ye, Kevin Hitchens, Lesley Foley, Yijen Wu, Jassy Wang, Chien Ho

Gold Nanoparticles Coated with Gadolinium Chelates as Multifunctional Contrast Agents ...... 3726 HeeKyung Kim, JiAe Park, JooHyun Kim, TaeJung Kim, YongMin Chang

Towards the Development of a Single PARACEST MRI Contrast Agent for Tumor PH Measurements ...... 3727 Vipul Ravindra Sheth, Guanshu Liu, Yuguo Li, Mark D. Pagel

Mapping Tissue Oxygen Tension Using 1H MR Based Nanoemulsion...... 3728 Praveen Gulaka, Tina Darjazanie, Ralph P. Mason, Vikram D. Kodibagkar

A Linear Phase Volume Excitation Coil ...... 3729 Donghyun Kim, J. Rock Hadley, Glen Morrell

Dynamic MRI Assays of Endothelial Permeability for the Non-Invasive Differentiation of Tumors with High from Tumors with Low VEGF-Activity ...... 3730 Clemens C. Cyran, Barbara Sennino, Yanjun Fu, Victor Rogut, Bundit Chaopathomkul, David M. Shames, Michael F. Wendland, Donald M. McDonald, Robert C. Brasch

Equilibrium Transcytolemmal Water Exchange Kinetics Depend on Yeast Cell ATP Level: Potentially High Spatiotemporal Resolution in Vivo MR Access to Cellular Energetics...... 3731 Yajie Zhang, Marie Poirier-Quinot, Charles S. Springer, James A. Balschi

Ferromagnetic Hybrid Nanoparticles for Guided Magnetic Hyperthermia ...... 3732 Vít Herynek, Emil Pollert, Pavla Jendelová, Ondøej Kaman, Miroslav Veverka, Pavel Veverka, Eva Syková, Milan Hájek,

Quantitative Molecular Imaging with a Dual Modality MR and Fluorescence Diffuse Optical Imaging System: Phantom Study...... 3733 Yuting Lin, Han Yan, Orhan Nalcioglu, Gultekin Gulsen

Direct Imaging of Ferumoxides Using Magnetic Particle Imaging: Sensitivity, and Instrument Construction ...... 3734 Patrick Goodwill, Gary Lee, Greig Scott, Pascal Stang, Steve Conolly

Improved Sensitivity in 19F Cellular Imaging Using Nonconvex Compressed Sensing...... 3735 Andre Fischer, Thomas Christian Basse-Lüsebrink, Thomas Kampf, Gesa Ladewig, Martin Blaimer, Felix Breuer, Guido Stoll, Wolfgang Rudolf Bauer, Peter Jakob

Diffusion Enhanced Sensitivity of BSSFP Quantification of Micron-Sized Superparamgnetic Iron Oxide...... 3736 Ahmed Magdy Elkady, Chris Van Bowen

Theoretical Considerations on the Quantification of Iron Oxide Labeled Cells in Vivo...... 3737 Thomas Kampf, Christian Herbert Ziener, Peter Michael Jakob, Wolfgang Rudolf Bauer

Differentiation of Intracellular and Extracellular SPIO Nanoparticles with R2 and R2 Mapping...... 3738 Wei Liu, Julien Senegas, Melissa Smith, Joseph A. Frank

Contrast Quantification of MPIO Labeled Cell Migration in the OB of Mice as a Read Out for the Efficiency of in Situ Labeling Strategies ...... 3739 Ruth Vreys, Marleen Verhoye, Annemie Van der Liden

Characterization of MR Contrast Enhancement in Murine Advanced Atherosclerotic Plaque After Administration of 24p3 (NGAL)-Targeted Micelles ...... 3740 Bernard C. te Boekhorst, Sandra M. Bovens, Krista den Ouden, Marcel G. Nederhoff, Kees W. van de Kolk, Maarten J. Cramer, Michiel Ten Hove, Pieter Doevendans, Robert E. Poelmann, Gerard Pasterkamp, Cornelis J. van Echteld

Low Threshold Detection of USPIO Concentrations in Different Environments Simulating Tissue Diversity ...... 3741 Sherif R. Fahmy, Todd Parrish

Separation of SPIO and Air Bubbles for Molecular Imaging ...... 3742 Tian Liu, Richard Wong, Pascal Spincemaille, Yi Wang

Endosomal Escape of Gd-Agents Activated by External Photochemical Stimulus ...... 3743 Eliana Gianolio, Francesca Arena, Anders Hogset, Silvio Aime

Harnessing Competing Endocytic Pathways for Overcoming the Tumor-Blood Barrier: MRI and NIR Imaging of Bifunctional Contrast Media...... 3744 Helena Migalovich-Sheikhet, Vyacheslav Kalchenko, Nava Nevo, Fortune Kohen, Michal Neeman

Electroporation Facilitated Intracellular Delivery of Contrast Agent to Probe Sub-Cellular Metabolite Compartmentalization in Vivo...... 3745 David Alberg Holm, Ian John Rowland

Micro-MR Angiography Using Gd-Loaded Micelles as Intravascular Contrast Agents in Mouse Models Amyloid Angiopathy ...... 3746 Lindsay K. Hill, Karen C. Briley-Saebo, Moustafa Douadi, Asad Baig, Susan Pun, Brian J. Nieman,Daniel H. Turnbull, Zahi A. Fayad, Thomas Wisniewski, Youssef Z. Wadghiri

Nanoparticle Detection of Vascular Inflammation in Mouse Carotid Artery at 7T...... 3747 Hisanori Kosuge, Masahiro Terashima, Masaki Uchida, Sarah Sherlock, Philip S. Tsao, Mark J.Young, Trevor Douglas, Hongjie Dai, Michael V. McConnell

Quantitative Molecular Imaging of Thrombi with Fibrin-Targeted PARACEST Perfluorocarbon Nanoparticles ...... 3748 Kejia Cai, Garry Kiefer, Shelton Caruthers, Samuel Wickline, Gregory Lanza, Patrick Winter

MRI Detection of Progenitor Cell Migrations During Postnatal Rat Brain Development by in Situ MPIO Labeling ...... 3749 Jian Yang, Jianxin Liu, Gang Niu, Rong Wang, Yong Liu, BoLang Yu, Ed Xuekui Wu

Identification of Advanced Atherosclerotic Plaque in Abdominal Aorta in a Murine Atherosclerotic Model with 24p3 (Mouse Homologue of Neutrophil Gelatinase-Associated Lipocalin)- Targeted Micelles and MRI...... 3750 Bernard C. te Boekhorst, Sandra M. Bovens, Krista den Ouden, Marcel G. Nederhoff, Kees W. van de Kolk, Maarten J. Cramer, Michiel ten Hove, Pieter Doevendans, Robert E. Poelmann, Gerard Pasterkamp, Cornelis J. van Echteld

Molecular Imaging Using Targeted Nanoparticles for Non-Invasive Detection of Renal Inflammation...... 3751 Natalie J. Serkova, Brian A. Larsen, Brandon Renner, Kendra M. Hasebroock, Erica L. Bradshaw-Pierce, Michael Holers, Conrad Stoldt, Joshua M. Thurman

Detection of Macrophage Accumulation After Heart Transplantation in a Rat Using a Novel Nano-Sized Iron Oxide Particle with High Relaxivity...... 3752 Haosen Zhang, Chih-Lung Chen, Qing Ye, Kevin Hitchens, Wen-Yuan Hsieh, Hsiu-Hua Huang, Yi-Shan Lin, HsinHsin Shen, Mu- Jen Young, Wei-Lin Yu, Ying-Ting Huang, Lesley Foley, Yijen Wu,Jassy Wang, Chien Ho

1H/19F Molecular MR-Imaging in Mouse Models of Acute and Chronic Inflammation ...... 3753 Gert Klug, Thomas Basse-Lüsebrink, Christian Schnell, Thomas Kampf, Elisabeth Bauer, Volker Herold, Marco Parczyk, Eberhard Rommel, Guido Stoll, Peter Michael Jakob, Wolfgang Rudolf Bauer

Gd-Containing Dendrimer as a Novel T1-Weighted Lung MRI Contrast Agent...... 3754 Wen-Yuan Hsieh, Dhakshanamurthy Thirumalai, Chien-Yuan Lin, Sui-Shan Lin, chen Chang, Shin-Shin Shen, Jassy Wang

Macromolecular Versus Small Molecular MRI Contrast Media for Monitoring Anti-Angiogenic Drug Effect of Bevacizumab on Experimental Human Breast Cancer Xenografts...... 3755 Clemens C. Cyran, Yanjun Fu, Victor Rogut, Bundit Chaopathomkul, David M. Shames, Michael F. Wendland, Robert C. Brasch

Intra-Individual In-Vivo Comparison of Gd-Contrast Agents for Quantitative Pharmacokinetic Analysis Using Dynamic Contrast Enhanced MR Imaging ...... 3756 Jiachao Liang, Steffen Sammet, Xiangyu Yang, Guang Jia, Yukihisa Takayama, Michael V. Knopp

Evaluation of an Iron Oxide Contrast Agent in the Visualization of Aortic Valve Sclerosis - A Preliminary Study ...... 3757 Amanda M. Hamilton, Andre JL Belisle, Brian K. Rutt, Ralph Weissleder, Derek R. Boughner, Kem A. Rogers

A Novel Macrophage Imaging Strategy Using Apoptotic Liposomes Incorporating Phosphatidylserine and AZ- Cholesterol...... 3758 Andrei Maiseyeu, Sashwati Roy, Georgeta Mihai, Nisharahmed Kherada, Orlando P. Simonetti,Chandan K. Sen, Sampath Parthasarathy, Sanjay Rajagopalan

Distortion Correction in Spinal Cord DTI: What’s the Best Approach? ...... 3759 Julien Cohen-Adad, Henrik Lundell, Serge Rossignol

Parallel RF Transmission for Clinical MR Imaging of the Human Spinal Cord at 3.0 Tesla: Preliminary Results ...... 3760 Michael Nelles, Roy König, Jürgen Gieseke, Marjolijn Guerand-van Battum, Marco Nijenhuis, Guido Kukuk, Daniel Thomas, Magnus Andersson, Beate Koberstein, Hans Heinz Schild, Winfried A. Willinek

Clinical Evaluation of Reduced Field-Of-View Diffusion Imaging of the Human Spinal Cord...... 3761 Greg Zaharchuk, Emine Ulku Saritas, Ajit Shankaranarayan, Dwight Nishimura, Nancy Jane Fischbein

Slice-By-Slice Motion Correction in Spinal Cord fMRI: SliceCorr ...... 3762 Julien Cohen-Adad, Serge Rossignol, Richard D. Hoge

Measurement of the Spinal Stenosis at and in the Presence of a Degenerated Cervical C5-C6 Segment as a Function of Head-Neck Posture...... 3763 Mahmoud Abdulhusain

3T MR Neurography in Lumbosacral Nerves: An Anatomical Study ...... 3764 Yan Ping Chen, Lin Yang

Susceptibility Weighted Imaging of the Spinal Veins...... 3765 Kinya Ishizaka, Kohsuke Kudoh, Noriyuki Fujima, Yuri Zaitsu, Satoshi Terae, Makoto Sasaki, Hiroki Shirato

Investigation of Venous Effects in Spinal Cord fMRI Using Hypercapnia ...... 3766 Claudine Gauthier, Julien Cohen-Adad, Jonathan Brooks, Serge Rossignol, Richard D. Hoge

Assessment of Cervical Spinal Disorders: Comparison of T2-Weighted IDEAL Water-Only Imaging and Fat- Saturated T2-Weighted FSE Imaging...... 3767 Kimihiko Sato, Takayuki Masui, Motoyuki Katayama, Hiroki Ikuma, Hidekazu Seo, Akihiko Kutsuna, Masayoshi Sugimura, Kenji Asano

Acquisition of 7T Human Spine Imaging ...... 3768 Bing Wu, Chunsheng Wang, Roland Krug, Douglas Kelley, Yong Pang, Sharmila Majumder, Xiaoliang Zhang

Distribution of MR Signal Intensity Within the Intervertebral Disc: Modifications Occurring with Adolescent Spondylolisthesis and Idiopathic Scoliosis...... 3769 Delphine Périé, Marjorie Riopel-Methot, Ariane Courville-LeBouyonnec, Daniel Curnier

DTI Abnormalities in Sheep Spinal Decompression Sickness: Anisotropy Differences and Histological Comparison ...... 3770 Elizabeth B. Hutchinson, Ian Rowland, Aleksey Sobakin, Neil Kleman, Dandan Sun, Peter Ferrazzano, Marlowe Eldridge, Mary Elizabeth Meyerand

Diffusion Tensor MRI of the Lumbar Spinal Cord in G93A-SOD1 Mice ...... 3771 Clare K. Underwood, Nyoman Dana Kurniawan, Tim Dana Butler, Robyn H. Wallace

Preliminary Investigation of Position Dependency of Radial Diffusivity in the Cervical Spinal Cord ...... 3772 Torben Schneider, Daniel C. Alexander, Claudia A.M. Wheeler-Kingshott

Acute in Vivo DTI Predicts Chronic Neurological Disability in Rats Suffering Traumatic Spinal Cord Injury...... 3773 Joong H. Kim, David K. S. Magnuson, Sheng-Kwei Song

Vascular Modulation of SCI: A Longitudinal MRI Study ...... 3774 Laura Sundberg, Juan Herrera, Ponnada Narayana

High Resolution White Matter T1 Mapping in Multiple Sclerosis at 7T...... 3775 Ali Mohammad Al-Radaideh, Matthew J. Brookes, Olivier Mougin, Emma C. Tallantyre, Nikos Evangelou, Su-Yin Lim, Alain Pitiot, Cris Constantinescu, Paul S. Morgan, Peter G. Morris, Penny A. Gowland

NAWM Changes as Assessed by Q-Space Analysis Correlate Inversely with T1-And T2-Lesion Volumes in MS Patients...... 3776 Katrin Weier, Eli Renate Gruener, Jochen G. Hirsch, Matthias Guenther, Michael Amann, Ludwig Kappos, Ernst-Wilhelm Radue, Achim Gass

Diffusion Tensor Tractogrpahy Quantification of Wallerian Degeneration of the Uncinate Fasciculus in Multiple Sclerosis ...... 3777 Khader M. Hasan, Arash Kamali, Amal Iftikhar, Sushmita Datta, Flavia Nelson, Jerry S. Wolinsky, Ponnada A. Narayana

Proton Magnetic Resonance Spectroscopy for Monitoring Disease Progression and Response to Treatment in Multiple Sclerosis...... 3778 Sanjeev Chawla, Sumei Wang, Ragini Verma, Elias R. Melhem, Clyde Markowitz, Harish Poptani

MRI Metrics of Nonlinear Atrophy in MS Disease Progression...... 3779 Dominik S. Meier, Charles R.G. Guttmann

In Vivo GABA Measurement in MS Sensorimotr Cortex -- A Marker for Disease Progression?...... 3780 Pallab K. Bhattacharyya, Robert Bermel, Micheal Phillips, Lael Stone, Mark Lowe

Tactile-Associated Recruitment of Cervical Cord Is Altered in MS Patients with Fatigue...... 3781 Martina Absinta, Maria Assunta Rocca, Giulia Longoni, Paola Valsasina, Federica Agosta,Domenico Caputo, Massimo Filippi

Identification of Benign Multiple Sclerosis Using Whole Brain N-Acetylaspartate ...... 3782 Daniel Rigotti, Robert I. Grossman, Beatrice Benedetti, Andrea Falini, Massimo Filippi, Oded Gonen

Brain Dynamic Susceptibility Contrast Perfusion Imaging Histograms in Primary Progressive Multiple Sclerosis...... 3783 Behrang Amini, Glyn Johnson, James S. Babb, Joseph Herbert, Robert I. Grossman, Matilde Inglese

Influence of Hypointense White Matter Lesions in Segmentation Based Assessment of Brain Volume. Implications for Clinical MS Studies...... 3784 Marco Battaglini, Antonio Giorgio, Maria Laura Stromillo, Nicola De Stefano

Semi-Automated Segmentation of Microhemorrhages Revealed by SWI ...... 3785 Randall R. Benson, Ramtilak Gattu, Balaji Myrtheunjayan, Zhifeng Kou, Ewart M. Haacke

Application of the Diffusion Standard Deviation Map for Detection of White Matter Reorganization After Stroke...... 3786 Siamak Pourabdollah-Nejad, David Hearshen, Quan Jiang, Douglas Noll, Panayiotis Mitsias, Brian Silver, Michael Chopp

Design of a SAR Compatible, 3T QMTI Protocol ...... 3787 Claudiu Schirda, Alexey Samsonov, Jennifer L. Cox, Robert Zivadinov

Proton Metabolite Changes in the Corpus Callosum, Thalamus and Brainstem Following Traumatic Brain Injury...... 3788 Varan Govind, Krithica Kaliannan, Gaurav Saigal, Stuart Gold, Jonathan Jagid, Leo Harris, Andrew A. Maudsley

Multimodality Imaging of Cerebral Schistosomiasis...... 3789 Albert J.S. Idema, Joyce Wilbers, P. Krooshof, A. C. Koetsveld, P. Wesseling, W. van der Graaf, A.Gijtenbeek, W. Oyen, A. Heerschap

In Vivo Multislice Mapping of Myelin Water Content of the Brain with T2 Signal Decay...... 3790 Dosik Hwang, Yiping P. Du

Comparison of Myelin Water Fraction in Cross-Regularized T1-Relaxograms of Normal White Matter at 3T and 7T and of Normal-Appearing White Matter at 3T...... 3791 Christian Labadie, Derek V. Ott, Thies H. Jochimsen, Jing-Huei Lee, Harald E. Möller

T2 Distribution Reflects Multiple Sclerosis Pathologies: Histology Driven Regions of Interest...... 3792 Thorarin A. Bjarnason, Cornelia Laule, Esther Leung, J Ross Mitchell, Piotr Kozlowski, Alex L. MacKay, G. R. Wayne Moore

Myelin Sensitive Multi-Component DESPOT Imaging in Multiple Sclerosis ...... 3793 Hagen H. Kitzler, Sean C. Deoni, Cyndi Harper-Little, Andrew Leung, Marcelo Kremenchutzky, Brian K. Rutt

Increased Anisotropy in Subcortical Gray Matter Structures: A Neurodegeneration Marker in Multiple Sclerosis...... 3794 Salem Hannoun, Francoise Durand-Dubief, Danielle Ibarrola, Jean Christophe Comte, Christian Confavreux, Dominique Sappey- Marinier,

Diffuse Subclinical Disease Activity in Normal-Appearing White Matter During Remission in Multiple Sclerosis: A Proton MR Spectroscopy Study...... 3795 Ivan I. Kirov, Vishal Patil, James Babb, Henry Rusinek, Joseph Herbert, Oded Gonen

Diffusion Tensor MRI Study of the Spinal Cord in Patients with Multiple Sclerosis ...... 3796 Jan von Meyenburg, Bertram Wilm, Anja Weck, Evelyn Gallus, Elisabeth Schätzle, Peter Boesiger, Norbert Goebels, Spyros S. Kollias

Accurate Estimation of Tissue Volumes by Means of Quantitative MR on Patients with Multiple Sclerosis ...... 3797 Janne West, Jan B. Warntjes, Peter Lundberg, Anne Marie Landtblom

Hydration Status Does Not Affect Brain Water Content or Myelin Water Fraction in Healthy Volunteers ...... 3798 Irene Margaret Vavasour, Cornelia Laule, Shannon H. Kolind, Roger Tam, Jimmy Lee, Burkhard Maedler, Anthony L. Traboulsee, David K. Li, Alex L. MacKay

Histograms of Multi-Component T2 Relaxation Imaging in Multiple Sclerosis: Characterization and Comparison with Histograms from Diffusion Tensor Imaging...... 3799 Shannon Heather Kolind, Cornelia Laule, Irene Vavasour, Burkhard Mädler, Alexander Rauscher, Virginia Devonshire, John Hooge, Joel Oger, Penelope Smyth, Anthony Traboulsee, Wayne Moore, David Li, Alexander MacKay

MRI Evidence That Gadolinium-Enhancing Lesions Seen Twelve Weeks After Commencing Rituximab Treatment Are Associated with Lower Blood-Brain-Barrier Disruption Than Those Seen Prior to Treatment in Patients with Relapsing-Remitting Multiple Sclerosis ...... 3800 Zografos Caramanos, Ilana Leppert, Sridar Narayanan, G Bruce Pike, Douglas Lorne Arnold

Serial Susceptibility Weighted (Phase) Imaging in Multiple Sclerosis...... 3801 Alexander Rauscher, Irene Vavasour, Cornelia Laule, Shanon Kolind, Talia Vertinsky, Wayne Moore, Burkhard Mädler, Joel Oger, Anthony Traboulsee, Davi Li, Alex MacKay

Comparing SWI and R2’ for the Detection of Iron Deposition in MS ...... 3802 Kecheng Liu, Michael Phillips, Jian Lin, Lael Stone, Robert Bermel, Erik Beall, Mark J. Lowe

Multiple Sclerosis Lesions at 3T. Scalars and Fibers ...... 3803 Mustafa Okan Irfanoglu, Steffen Sammet, Raghu Machiraju, Michael` V. Knopp

Directional Diffusivities in Human Spinal Cord Correlate with Functional Outcome ...... 3804 Junqian Xu, Eric C. Klawiter, Tammie L.S. Benzinger, Robert T. Naismith, Sheng-Kwei Song, Anne H. Cross

Depiction of Cortical Lesions in Multiple Sclerosis at 7T: Comparison with Immunohistochemistry ...... 3805 Petra Schmalbrock, Francisco Aguila, David Pitt, Aaron Boster, Michael Racke, Kottil Rammohan, Wei Pei, Steffen Sammet, Michael Vincent Knopp

Calibrated fMRI Reveals Altered Neurovascular Coupling with Age During a Cognitive Stroop Task...... 3806 Laura M. Parkes, Guy Lumley, Rafat S. Mohtasib, Hedley Emsley, Jonathan A. Goodwin

Age-Related Increases in Spatial Variability of fMRI-BOLD Activation Is Neural or Vascular in Origin...... 3807 Sridhar S. Kannurpatti, Michael A. Motes, Bart Rypma, Bharat B. Biswal

Age Effects on Low Frequency Physiological Fluctuations in Resting BOLD fMRI...... 3808 Lirong Yan, Yan Zhuo, Bo Wang, Rong Xue, Geoffrey Aguirre, Jiongjiong Wang

Lateralization of Language Pathways During Adolescence and Early Adulthood...... 3809 Luca Pugliese, Flavio Dell'Acqua, Michel Thiebaut de Schotten, Sanja Budisavljevic, Steve Williams, Declan Murphy, Marco Catani,

Age and Gender Related Changes of Human Brains Using Magnetic Resonance Hybrid Diffusion Imaging...... 3810 Yu-Chien Wu, Frances B. Haeberli, Aaron S. Field, Andrew L. Alexander

A Computational DTI Template for Aging Studies...... 3811 Hui Zhang, Paul Yushkevich, Daniel Rueckert, James Gee

Template Selection for fMRI Studies of Elderly Subjects ...... 3812 Minjie Wu, Lei K. Sheu, Carmen Andreescu, James T. Becker, Costin Tanase, Howard J. Aizenstein

Radial Diffusivity Template of Corpus Callosum. Correlation with Normal Aging ...... 3813 Fabrizio Fasano, Mara Cercignani, Barbara Basile, Carlo Caltagirone, Marco Bozzali

Interrelationships of Brain Microstructural and Macrostructural Abnormalities in the Oldest Old...... 3814 Vijay K Venkatraman, Howard Jay Aizenstein, Anne Barbara Newman, Caterina Rosano

Tract Based Spatial Statistics Reveals Longitudinal White Matter Changes in Normal Ageing...... 3815 Thomas Richard Barrick, Rebecca Anne Charlton, Christopher Alan Clark, Hugh Stephen Markus

Tract-Specific White Matter Integrity and Cognitive Ability in Youth and Old Age ...... 3816 Susana Muñoz Maniega, Lars Penke, Jonathan D. Clayden, Catherine Murray, Mark E. Bastin, Alan J. Gow, Joanna M. Wardlaw, Ian J. Deary

Gender and Age Dependence of Cingulum and Corpus Callosum in Healthy Volunteers Assessed by Diffusion Tensor Imaging: A Virtual Dissection Study ...... 3817 Hanna Järnum, A.- M. Stausholm, Elena G. Steffensen, Carsten Wiberg Simonsen, Søren Lundbye-Christensen, Tina Obel, Ernst Torben Fründ, E-M. Larsson

13C MRS During [3-13C]lactate Infusion Under Hyperinsulinemic-Hypoglycemic Conditions Reveals Compartmentalized Lactate Metabolism in Human Brain ...... 3818 Henk De Feyter, Kitt Falk Petersen, Graeme F. Mason, Gerard Sanacora, John Krystal, Barbara Gulanski, Robert S. Sherwin, Kevin L. Behar, Robin A. de Graaf, Fawzi Boumezbeur, Gerald I. Shulman, Douglas L. Rothman

Regional Age-Related Changes in the Monkey Brain Measured with Proton Magnetic Resonance Spectroscopy...... 3819 Xiaoying Fan, Stephen Schettler, Sahil Jain, Donna Murray, Dae-Shik Kim, Douglas Rosene, Ron Killiany, Itamar Ronen

Quantitative Relaxographic Assessment of Age Related Changes in Non-Human Primate Brain...... 3820 Jeffrey Moses Njus, James R. Pollaro, Mathew T. Snodgrass, Vincent B. Warren, Ethan Muldoon, John Cunneen, Steven G. Kohama, William D. Rooney

T2 Relaxation Time Is Decreased in Hippocampus of Aged Rats: Analysis of the Effect of the Peroxisome Proliferator-Activated Receptor g Agonist Rosiglitazone...... 3821 Christoph Blau, Ranya Bechara, Christian Matthias Kerskens, Marina Anne Lynch

Optimisation of T2 Imaging for the Investigation of White-Matter MS Lesion Heterogeneity...... 3822 Jennifer Elizabeth Dixon, Matthew J. Brookes, Paul S. Morgan, Ali M. Al-Radaideh, Emma C. Tallantyre, Nikos Evangelou, Peter G. Morris

Regional Assessment of WM and GM Damage in Patients with Early MS: A VBM and TBSS Investigation ...... 3823 Eytan Raz, Mara Cercignani, Emilia Sbardella, Porzia Totaro, Carlo Pozzilli, Marco Bozzali, Patrizia Pantano

Relating Thalamic Atrophy and White Matter Lesions at the Earliest Stages of Multiple Sclerosis ...... 3824 Bagrat Amirbekian, Mason Shieh, SungWon Chung, Darin T. Okuda, Daniel Pelletier, Roland G. Henry

Impairment of Emotional Processing in Multiple Sclerosis: An Event-Related fMRI Study...... 3825 Barbara Basile, Ugo Nocentini, Giovanna Comanducci, Rosalba Mannu, Carlo Caltagirone, Marco Bozzali

Serial MRI in Epidemiology: Seasonal Occurrence of New MS Lesions ...... 3826 Dominik S. Meier, Charles R.G. Guttmann

Morphogenesis of Cerebral Cortex in Healthy Aging and Multiple Sclerosis: Potential Marker of Early White Matter Injury ...... 3827 Martin Kavec, Mathieu Vokaer, Danielle Balériaux

Normal-Appearing White Matter Quantitative Magnetization Transfer Imaging Correlates with Disability in Multiple Sclerosis...... 3828 Barbara Basile, Mara Cercignani, Fabrizio Fasano, Ugo Nocentini, Carlo Caltagirone, Marco Bozzali

Preservation of Brain Adaptive Properties Contributes to the Clinical Picture of Benign Multiple Sclerosis...... 3829 Maria Assunta Rocca, Antonia Ceccarelli, Sebastiano Galantucci, Angelo Ghezzi, Elisabetta Pagani, Andrea Falini, Giancarlo Comi, Massimo Filippi,

Fiber-Tracking Through Multiple Sclerosis Lesions Using Probabilistic Tracking...... 3830 Alexander B. Pine, Stephen Jones, Mark Lowe, Ken Sakaie, Micheal Philips

Contrast Simulation and Measurement in the Optic Nerve at 3T ...... 3831 Lauren Wallis, LiSze Chow, Martyn NJ Paley, Hardeep Singh Mudhar, Simon Hickman, Nigel Hoggard

Structural Differences in OCB-/+ Patients with Clinically Isolated Syndrome Suggestive of MS...... 3832 Yasheng Chen, Valerie Jewells, Danielle Speer, Taylor Stone, Silva Markovic-Plese, Hongyu An,Hongtu Zhu, Dinggang Shen, Weili Lin

MRI Features of the Inflamed Spine: A Comprehensive Comparison of Spinal Lesions in Acute Transverse Myelitis and Multiple Sclerosis in Children ...... 3833 Helen Branson, Monica Makhijma, Manohar Shroff, Sandra Magalhaes, Leonard H. Verhey, Brenda Banwell

Atrophy and Shape Changes in Deep Gray Matter in Multiple Sclerosis: A Tensor Based Morphometry ...... 3834 Guozhi Tao, Sushmita Datta, Renjie He, Ponnada A. Narayana

Apparent Anisotropy in a LES Model of Demyelination Observed by QSI: Effect of Experimental Parameters ...... 3835 Debbie Anaby, Ian D. Duncan, Yoram Cohen

Sequential Monitoring of Fractional Anisotropy (FA) and Apparent Diffusion Coefficient (ADC) in an Experimental Model of Demyelination by DTI and DWI...... 3836 Krithika Balasubramanian, Uma Sharma, S Senthil Kumaran, S Muthuraj, Dipti N. Prasad, Naranamangalam R. Jagannathan

Hybrid HYPR MRA...... 3837 Yijing Wu, Steven R. Kecskemeti, Patrick Turski, Charles A. Mistretta

Non-Contrast Enhanced Three-Dimensional MR Digital Subtraction Angiography at a Temporal Resolution of 100 Msec ...... 3838 Masaaki Hori, Nobuyuki Shiraga, Yasushi Watanabe, Shigeki Aoki, Sachiko Isono, Masao Yui,Tsutomu Araki

Non-Contrast-Enhanced 4D Intracranial MR Angiography with 4D NATIVE TrueFISP...... 3839 Xiaoming Bi, Peter Weale, Peter Schmitt, Sven Zuehlsdorff, Renate Jerecic

Effects of Translation and Pulsation on 3D Contrast-Enhanced MRA of the Carotid Arteries ...... 3840 Dean Thomas Jeffery, Derek J. Emery, Alan H. Wilman

4D Radial-Sliding Window MR Angiograpy of Intracranial Arteriovenous Malformations: Correlation with Digital Subtraction Angiography...... 3841 Christopher Sean Eddleman, Hyun Jeong, Michael C. Hurley, Christopher C. Getch, Guilherme Dabus, Bernard R. Bendok, Hunt H. Batjer, Timothy J. Carroll qCBF: A Comparison of the Accuracy Between the Bookend Technique, Empirical Reference Values and [O15]- H20 PET in Moyamoya Patients...... 3842 Vishal Parikh, John Lee, Wanyong Shin, Jessy Mouannes, Avi Snyder, Colin Derdeyn, Timothy Carroll

The Potential of MRI and MRA in the Evaluation of Cerebral Vasospasm in a Rat Model of Subarachnoid Hemorrhage ...... 3843 Shashank R. Ramdurg, Ashish Suri, Deepak Gupta, Sujeet Kumar Mewar, Uma Sharma, Naranamangalam R. Jagannathan, Bhavani S. Sharma

Comparision of High Temporal Resolution 2D Time Resolved Blood Bolus Tagging MRA and 3D Time Resolved Contrast Enhanced MRA for the Assessment of Hemodynamics in Patients with Cerebral Arteriovenous Malformations...... 3844 Marco Essig, Frederik Giesel, Julien Dinkel, Michael Bock

Effects of Administration Routes on Migration and Distribution of Neural Progenitor Cells Transplanted Into Rats with Ischemia ...... 3845 Lian Li, Quan Jiang, Gaungliang Ding, Li Zhang, Zhenggang Zhang, Qingjiang Li, James R. Ewing, Michael Chopp

Neuroprotective Benefit in a Neurorestorative Treatment of Embolic Stroke with EPO in Rats Detected by MRI...... 3846 Guangliang Ding, Quan Jiang, Lian Li, Li Zhang, Ying Wang, Zhenggang Zhang, Swayamprava Panda, Qingjiang Li, James R. Ewing, Michael Chopp

Contrast Agent Leakage to Lateral Ventricle After Transient Cerebral Ischemia ...... 3847 Aysan Durukan, Daniel Strbian, Ivan Marinkovic, Miia Pitkonen, Eric Pedrono, Usama Abo-Ramadan, Turgut Tatlisumak

Alterations of DTI Indices in Bilateral Corticospinal Tract Following Unilateral Stroke in a Rat Model ...... 3848 Deqiang Qiu, Maurits P.A. van Meer, Pek-Lan Khong, Rick M. Dijkhuizen

Characterization of Early Hypoxic-Ischemic Injuries to the Neonatal Mouse Cerebral Cortex and Hippocampus Using Diffusion Tensor Imaging ...... 3849 Julie Nogee, Brian S. Stone, Devin W. Mack, Lee J. Martin, Michael I. Miller, Susumu Mori, Frances J. Northington, Jiangyang Zhang

Simultaneous EEG and MRI in a Rodent Model of Neonatal Hypoxia-Ischemia ...... 3850 Ward Jennekens, Wim M. Otte, Maurits P.A. van Meer, Rick M. Dijkhuizen, Pieter F.F. Wijn,

Characterization of White Matter Reorganization in Neonatal Hypoxic-Ischemic Cerebral Injury Using Diffusion Tensor Imaging...... 3851 Kevin C. Chan, Pek-Lan Khong, Ho-fai Lau, Ed X. Wu

Functional MRI of Visual Responses in the Late Stage of Neonatal Hypoxic-Ischemic Encephalopathy ...... 3852 Kevin C. Chan, Matthew Man Hin Cheung, Ed X. Wu,

Relation Between Cerebral Perfusion Territories and Location of Cerebral Infarcts...... 3853 Jeroen Hendrikse, Esben Thade Petersen, Amandine Chèze, Soke Miang Chng, Narayanaswamy Venketasubramanian, Xavier Golay

Double Inversion Recovery (DIR) MR Imaging in Detections of Acute Stroke Lesions...... 3854 Chung-Min Lee, Geon-Ho Jahng, Chang Woo Ryu, Hyun Cheol Kim, Dal Mo Yang

Sequential MR Imaging of Early Reperfusion in Acute Ischemic Stroke Patients...... 3855 Hongyu An, Andria L. Ford, Katie Vo, Jin-Moo Lee, William J. Powers, Weili Lin

Acute Normalization of Apparent Diffusion Coefficient Values May Not Reflect Tissue Recovery in Acute Stroke Patients...... 3856 Hongyu An, Andria L. Ford, Katie Vo, William J. Powers, Jin-Moo Lee, Weili Lin

More Is Better: Rater Consensus on Lesion Outline in Acute Stroke Improves Predictive Models ...... 3857 Kristjana Yr Jonsdottir, Leif Østergaard, Kim Mouridsen

Acute and Follow-Up MCA Infarct Probability Maps in Stroke Patients with MCA Occlusion ...... 3858 Charlotte Rosso, Guillaume Auzias, Rémi Cuingnet, Sophie Crozier, Eric Bardinet, Stéphane Lehéricy, Sylvain Baillet, Yves Samson

Evaluation of Three Ischemic Signs and Ischemic Extent by T2-Weighted 3-Tesla MRI ...... 3859 Masafumi Harada, Hitoshi Kubo, Hiromu Nishitani, Tsuyoshi Matsuda

Assesment of Blood-Brain Barrier Injury Following Acute Intracerebral Hemorrhage by DCE MRI...... 3860 Didem Bilensoy Aksoy, Roland Bammer, Chitra Venkatasubramanian, Sandeep N. Gupta, Michael Mlynash, Christine A. C. Wijman

Transient Blood-Brain Barrier Disruption and Changes in Brain Electrolytes at the Edge of the Ischemic Core ...... 3861 Victor E. Yushmanov, Alexander Kharlamov, Fernando E. Boada, Stephen C. Jones

The Measurement of Spatially-Dependant Tissue Sodium Concentration Increase in a Rodent MCAO Stroke Model ...... 3862 Friedrich Wetterling, Sven Junge, Arno Nauerth, Oliviero Gobbo, I. Mhairi Macrai, Andrew J. Fagan

MRI of Bilateral Sensorimotor Network Activation by Direct Intracortical Stimulation in Rats After Unilateral Stroke...... 3863 Maurits Pieter Adriaan van Meer, Kajo van der Marel, Willem Maarten Otte, Jan Willem Berkelbach van der Sprenkel, Rick Michiel Dijkhuizen

Infarct Volume Determined by Acute ADC Correlates Neurological Outcome in Stroke Mice ...... 3864 Chia-Wen Chiang, Tzy-Haw Wu, Joong H. Kim, Sheng-Kwei Song

MRS at 3 Tesla in Brain of Schizophrenic Patients: Elevated Glutamate in Hippocampus Decreases on Therapy ...... 3865 Florian Schubert, Frank Seifert, Karolina Leopold, Michael Krebs, Ines Haeke, Juergen Gallinat, Martin Schaefer

Cerebral Perfusion in Patients with Major Depression - A Pseudo Continuous Arterial Spin Labelling MRI Study ...... 3866 Hanna Järnum, Elena G. Steffensen, Linda Knutsson, Ernst Torben Fründ, Carsten Wiberg Simonsen, Ib Scheel Thomsen, Ajit Shankaranarayanan, David C. Alsop, Finn Taagehøj Jensen, Povl Munk Jørgensen, E-M. Larsson

Elevated Lactate Levels and Impaired Neural Circuit in Manic Bipolar Disorder I ...... 3867 Wen-Jang Chu, Matthew M. Norris, Jing-Huei Lee, Kelly B. Jarvis, Xin Wang, Mi-Jung Kim, Melissa P. DelBello, Stephen M. Strakowski, Caleb Adler

Effects of Cortisol on Brain Metabolism: A H-1 Magnetic Resonance Spectroscopy Study at 3.0T ...... 3868 Michael Scheel, Andreas Stroehle, Harald Bruhn

Hippocampal Alterations in Congenital Learned Helpless Rats After Electroconvulsive Seizures Detected with in Vivo 1H MR-Spectroscopy at 9.4T ...... 3869 Sarah Biedermann, Sascha Sartorius, Lei Zheng, Barbara Vollmayr, Peter Gass, Gabriele Ende,Wolfgang Weber-Fahr

Direct and Noninvasive Measurement of Cerebral Metabolic Rate of ATP in Cat Brain and Its Physiological Implications...... 3870 Xiao-Hong Zhu, Yi Zhang, Kamil Ugurbil, Wei Chen

Metabolic Profiles in the Brain of a Transgenic Mouse Model of Type 2 Diabetes Assessed Using in Vivo 1H MRS at 9.4 T ...... 3871 Wen-Tung Wang, Bhumsoo Kim, Eva Feldman, In-Young Choi,

Glycine Tissue Level in Medulla Oblongata Measured in Vivo with 1H MRS at 9.4 T in Rat Brain...... 3872 Lijing Xin, Giulio Gambarota, João Miguel das Neves Duarte, Vladimir Mlynarik, Rolf Gruetter

Towards Structure Specific Quantitative Macromolecular Content of Mouse Brain from Chemical Shift Imaging Data at 11.7 T...... 3873 Hélène Ratiney, Michaël Sdika, Olivier Beuf, Yann Le Fur, Sophie Cavassila

In Vivo MRS Studies of Metabolic Changes Induced by Recurrent Antecedent Hypoglycemia Probed by 3- 13C- Lactate ...... 3874 Lihong Jiang, Raimund I. Herzog, Graeme F. Mason, Robin A. de Graaf, Douglas L. Rothman, Robert S. Sherwin, Kevin L. Behar

Detection of GABA C1 Turnover in Rat Brain in Vivo ...... 3875 Jehoon Yang, Jun Shen

Evolution of the Neurochemical Profile in the Frontal and Occipital Cortex of the Developing Mouse Determined by in Vivo 1H NMR Spectroscopy at 14.1 T...... 3876 João M. N. Duarte, Anita Frank, Kim Q. Do, Rolf Gruetter

Fast 13C Label Exchange Between Mitochondria and Cytosol in Brain Revealed by Saturation Transfer Spectroscopy...... 3877 Jehoon Yang, Su Xu, Jun Shen

Hypothalamic Neuronal Activity and Intermediary Metabolism in ob/ob Mice ...... 3878 Inês R. Violante, Tiago B. Rodrigues, Laura Nieto-Charques, Sebastián Cerdán

Measurements of Glial Metabolic Fluxes with 11C-Acetate Using Positron Emission and 1H{13C} NMR Spectroscopy...... 3879 Bernard Lanz, Lijing Xin, Matthias T. Wyss, Bruno Weber, Alfred Buck, Rolf Gruetter

Highly Accurate Quantification of Proton MR Spectroscopy in Rat Brain in Vivo at 16.4 T...... 3880 Sung-Tak Hong, David Zsolt Balla, Shajan Gunamony, Kamil Ugurbil, Rolf Pohmann

Subcellular Transfer of Reducing Equivalents in the Neuronal and Glial Compartments of the Adult Rat Brain After Portocaval Anastomosis and Chronic Moderate Hyperammonemia as Detected by (13C, 2H) NMR...... 3881 Tiago Brandao Rodrigues, Regina Rodrigo, Omar Cauli, Vicente Felipo, Sebastián Cerdán

Detecting Progression of Alzheimer’s Disease Pathology in the Triple Transgenic Mouse Brain Using 1H MRS...... 3882 Jieun Kim, Sang-Pil Lee, Mary L. Michaelis, In-Young Choi

Distribution of Temperature Changes and Dynamics in Rat Brain After 3,4- Methylenedioxymethamphetamine (MDMA) Injection by 1H CSI ...... 3883 Daniel Coman, Lihong Jiang, Fahmeed Hyder, Kevin Behar

Understanding Your Inhibitions. a Functional Metabolomic Approach to the GABAergic System...... 3884 Caroline Rae, Fatima Nasrallah, Julian Griffin, Vladimir J. Balcar

Chronic Endogenous Glucocorticoid Treatment Induces Hippocampal Volume Loss – an in Vivo MRI Study in Rats at 7T ...... 3885 Mirjam I. Schubert, Simon Beckett, Clare Spicer, Charles A. Marsden, Dorothee P. Auer

Redox-Mapping MRI in Rodent Brain with Nitroxide Contrast Agents ...... 3886 Hirotada G. Fujii, Katsuya Kawanishi, kouichi Itoh

Magnetic Resonance Analysis of the Effects of Acute Ammonia Intoxication on a Rat Brain...... 3887 Pilar Lopez-Larrubia, Omar Cauli, Tiago Brandao Rodrigues, Sebastian Cerdan, Vicente Felipo

Aluminum Mediated Changes in Rat Brain Using MRI/ MTC Imaging...... 3888 Deepa Prajapati, Sanjay Annarao, Sandeep Tripathi, Abbas Ali Mahdi, Farzana Mahdi, Mahdi Hasan, Raja Roy, C L. Khetrapal

Relationship of Functional Activation Deficit and Anatomical Atrophy in the Primary Olfactory Cortex and Hippocampus of Alzheimer’s Disease...... 3889 Jianzhong Yin, Jianli Wang, Paul Eslinger, Lindsi DeArment, Erin Zimmerman, Jeffery Vesek, Ji Qi, James Connor, Qing X. Yang

T1rho (T1p) MRI and CSF Analysis in Prediction of Alzheimer’s Disease at Early Stage...... 3890 Mohammad Haris, Erin McArdle, Matthew Sochor, Matthew Fenty, Anup Singh, Christos Davatzikos, John Q. Trojanowski, Elias R. Melhem, Christopher M. Clark, Ravinder Reddy, Arijitt Borthakur

Early Marker for Alzheimer’s Disease: Hippocampus T1rho (T1p ) Estimation...... 3891 Mohammad Haris, Erin McArdle, Matthew Sochor, Matthew Fenty, Anup Singh, Christos Davatzikos, John Q. Trojanowski, Elias R. Melhem, Christopher M. Clark, Ravinder Reddy, Arijitt Borthakur

T1rho (T1p) MR Imaging in Alzheimer’ Disease and Parkinson’s Disease ...... 3892 Anup Singh, Mohammad Haris, Erin McArdle, Matthew Sochor, Matthew Fenty, Christos Davatzikos,John Q. Trojanowski, Elias R. Melhem, Christopher M. Clark, Ravinder Reddy, Arijitt Borthakur

Reduced Resting-State Connectivity in the Brain's Default Mode Network in Patients with Mild Forms of Relapsing-Remitting MS...... 3893 Michael Amann, Jochen Gunther Hirsch, Lea Sybil Doessegger, Iris Katherina Penner, Katrin Weier, Ernst Wilhelm Radue, Ludwig Kappos, Achim Gass

Functional Plasticity in the Human Motor System After Transfer of Intercostal Nerves to the Biceps Muscle...... 3894 Mattijs Elschot, Serge A R B Rombouts, Martijn JA Malessy, Catrien A. Schimmelpenninck, Matthias J P van Osch, Ivan Toni, David G. Norris, Mark A. van Buchem, Pieter F. Buur

Evaluation of Therapy Effects in Patients with Chronic Spatial Neglect Using fMRI as a Quantitative Tool...... 3895 Julia Reinhardt, Martina Wengenroth, Gundhild Leifert-Fiebach, Peter Schneider, Maria Blatow, Anouk Welfringer, Ralf Babinsky, Tobias Brandt, Christoph Stippich

Effects of Cranial-Nerve Non-Invasive Neuromodulation (CN-NINM) on Neural Activity as Measured by BOLD- fMRI...... 3896 Joseph Wildenberg, Mitch Tyler, Yuri Danilov, Mary Meyerand

Analyses of Susceptibility-Induced Effects on DTI Indexes in Patients with Neurodegenerative Diseases ...... 3897 Songfan Xu, Geon-Ho Jahng, Norbert Schuff, Dieter J. Meyerhoff, Michael W. Weiner

Fiber Bundle Atrophy in Friedreich’s and Spinocerebellar Ataxia ...... 3898 Elisabetta Pagani, Andrea Ginestroni, Federica Agosta, Mario Mascalchi, Massimo Filippi

Similar Microstructure Abnormality of Anterior Cingulate Region in Depressed and Undepressed Parkinson's Disease: Evidence from Diffusion Tensor Imaging...... 3899 JiangTao Liu, KunCheng Li

Abnormalities of Supratentorial White Matter in Multiple System Atrophy: Diffusion Tensor Imaging Observation ...... 3900 Khin Khin Tha, Satoshi Terae, Ichiro Yabe, Tamaki Miyamoto, Hiroyuki Soma, Yuri Zaitsu, N. Fujima, H. Sasaki, H. Shirato

The Role of Structural Disconnection Secondary to Regional Grey Matter Loss in the Progression of Alzheimer's Disease...... 3901 Laura Serra, Mara Cercignani, Tommaso Gili, Roberta Perri, Lucia Fadda, Carlo Caltagirone, Marco Bozzali

DTI Studies in Patients with Alzheimer's Disease, Mild Cognitive Impairment, and Cognitive Normal with Minimizing Contributions of Background Gradients ...... 3902 Songfan Xu, Geon-Ho Jahng, Norbert Schuff, Dieter J. Meyerhoff, Michael W. Weiner

Comparison of Brain Metabolism and Atrophy in Prodromal Alzheimer's Disease...... 3903 David S. Karow, Linda K. McEvoy, Christine Fennema-Notestine, Donald J. Hagler Jr. , Robin G. Jennings, Carl K. Hoh, Anders M. Dale,

Whole Brain N-Acetylaspartate Quantification Comparison Between Healthy Elderly, Mild Cognitively Impaired and Alzheimer’s Patients: Evidence for Different Clinical Cohorts...... 3904 Amit Gokhale, Lidia Glodzik, Songtao Liu, Juchen Hirsch, L Achtnichts, A Monsch, Achim Gass, Oded Gonen

Proton Magnetic Resonance Spectroscopy Along the Pyramidal Tract of Patients with Amyotrophic Lateral Sclerosis ...... 3905 Michal Bittsansky, Stefan Sivak, Hubert Polacek, Monika Turcanova-Koprusakova, Egon Kurca, Dusan Dobrota

Proton Magnetic Resonance Spectroscopy (1H-MRS) on the Spinal Cord in Amyotrophic Lateral Sclerosis (ALS) at 3T ...... 3906 Nashiely Pineda Alonso, Michael Benatar, Xiaoping Hu, John Carew

Correlation of MRS Markers with HIV DNA in Patients Well-Controlled on HAART...... 3907 Napapon Sailasuta, Victor Valcour, Bruce Shiramizu, Aaron McMurtray, James Taylor, Kalpana Kallianpur, Cecilia Shikuma

MR Spectroscopy of GABA and Other Brain Metabolites in Smelters Exposed to Manganese...... 3908 Ulrike Dydak, Liling Long, Henry Zhu, Wenmei Li, Yueming Jiang, Jian Chen, X. Fu, Shuguang Hu, Richard A.E. Edden, Dieter Meier, Michael Aschner, James Murdoch, Wei Zheng

Age-Related Microstructural Alterations Increase the Relationship Between Radial and Axial Diffusivities...... 3909 Agnieszka Zofia Burzynska, Claudia Preuschhof, Lars Bäckman, Lars Nyberg, Shu-Chen Li, Ulman Lindenberger, Hauke Reiner Heekeren,

Dissociation Between Aging of Anterior and Posterior Corpus Callosum Microstructure Depends on Genotype ...... 3910 Kristen Michelle Kennedy, Karen Michelle Rodrigue, Susan Land, Naftali Raz

Variation in DTI-FA as a Function of Age and Brain Region: Setting the Stage for Mild TBI...... 3911 Randall R. Benson, Ramtilak Gattu, Naftali Raz, Kristen M. Kennedy, Zhifeng Kou, Ewart M. Haacke,

Sensorimotor Network Rewiring in Patients with Mild Cognitive Impairment and Alzheimer’s Disease ...... 3912 Federica Agosta, Maria Assunta Rocca, Elisabetta Pagani, Martina Absinta, Maria Luisa Gorno-Tempini, Giuseppe Magnani, Alessandra Marcone, Monica Falautano, Giancarlo Comi, Massimo Filippi

Hemi-Parkinson’s Disease Rat Model: Correlation Between Behaviour, Histology and MRI...... 3913 Giuseppina Confalone, Daniela Minchella, Tiziana Florio, Eugenio Scarnati, Antonello Sotgiu, Marcello Alecci

Microanatomy of the Primate Mouse Lemur Brain at 7T After Passive Staining...... 3914 Anne Bertrand, Alexandra Petiet, Sébastien Mériaux, Christopher J. Wiggins, Audrey Kraska, Olène Dorieux, Fabienne Aujard, Marc Dhenain

Quantitative Phenotype Characterization of Developing Mouse Brains by Diffusion Tensor Imaging: Application for the Frizzled-4-/- Mutant Mice ...... 3915 Manisha Aggarwal, Xin Ye, Jeremy Nathans, Michael I. Miller, Susumu Mori, Jiangyang Zhang

Diffusion Tensor Imaging Detects Axonal Injury and Demyelination in the Spinal Cord and Brain of a Murine Model of Globoid Cell Leukodystrophy...... 3916 Joong Hee Kim, Alex A. Hofling, Mark S. Sands, Sheng-Kwei Song

Correction of MRI Scaling Parameters: A Comparison of Phantom and Registration Methods on the ADNI Dataset ...... 3917 Matthew J. Clarkson, Casper Nielsen, Kelvin L. Leung, Josephine Barnes, Jennifer L. Whitwell, Jeffrey Gunter, Clifford R. Jack, Nick C. Fox, Sebastien Ourselin

Correcting for Partial Volume Effects in Arterial Spin Labeling Perfusion Imaging of Alzheimer's Disease...... 3918 Iris Asllani, Christian G. Habeck, Nicolaos Scarmeas, Truman R. Brown, Yaakov Stern

Prediction of Conversion from Mild Cognitive Impairment to Alzheimer’s Disease Based on Regional Brain Volume Measured on MRI and MRI-Guided Perfusion Measured by SPECT...... 3919 Huali Wang, Ke Nie, Malcolm B. Dick, Mark Mandelkern, Orhan Nalcioglu, Min-Ying Lydia Su

Body Mass Index and Neuronal Viability in Healthy Cognitively Normal Elderly- A Magnetic Resonance Spectroscopy Study ...... 3920 Stefan Gazdzinski, Rachel Millin, Lana Kaiser, Michael W. Weiner, Dieter J. Meyerhoff

Deconvolved SWI Phase Model of Patients with Parkinson Disease...... 3921 Guenther Grabner, Siegfried Trattnig, Markus Barth

The Diagnostic Utility of Susceptibility Weighted Imaging (SWI) in Amyotrophic Lateral Sclerosis...... 3922 Akiko Jingu, Makoto Amanuma, Keigo Endou

Minocycline Reveals Neuroprotection in an Accelerated Rhesus Macaque Model of NeuroAIDS by 1H MR Spectroscopy...... 3923 Eva-Maria Ratai, Chan-Gyu Joo, Jeffrey Bombardier, Julian He, Lakshman Annamalai, Tricia H. Burdo, Jennifer H. Campbell, Caroline Soulas, Patrick Autissier, Susan V. Westmoreland, Kenneth Williams, R. Gilberto Gonzalez

High B-Value Cerebral DWI and Basal Nuclei ADC Measurements in Variant and Sporadic Creutzfeldt-Jakob Disease...... 3924 Harpreet Hyare, John Thornton, Durrenajaf Siddique, John Stevens, John Collinge, Tarek Yousry, Rolf Jager

Does Obesity Account for Brain Injury in Alcohol Dependent Individuals? – a Multimodal Magnetic Resonance Study at 1.5T...... 3925 Stefan Gazdzinski, Anderson Mon, Timothy C. Durazzo, Dieter J. Meyerhoff

Assessment of Iron Distribution in Hallevorden-Spatz Syndrome Using Phase Imaging and Relaxation Rate Measurements...... 3926 Jerzy (Urick) Szumowski, Susan Hayflick, Kirsten Gaarder, Erhan Bas, Erwin Schwarz, Deniz Ergogmus

Abnormal Corticostriatal Pathway in Patients with Tourette Syndrome...... 3927 Rajkumar Munian Govindan, Malek I. Makki, Benjamin J. Wilson, Mike E. Behen, Harry T. Chugani

In Vivo 4D Visualization of CSF Flow: Healthy Volunteers and Hydrocephalus...... 3928 Francesco Santini, Tilman Schubert, Klaus Scheffler, Stephan G. Wetzel

Robust Intensity Normalisation and Automatic Intensity Window Selection for the Calculation of the Boundary Shift Integral ...... 3929 Kelvin Ka-fai Leung, Matthew Clarkson, Nick C. Fox, Sebastien Ourselin,

Use of the Talairach Proportional Grid System for ROI Quantification of Cerebral Blood Volume Maps of the Brain...... 3930 Santiago Reig, Juan Adán Guzmán de Villoria, Javier Olazarán, Isabel Cruz, Maria Lacalle, Eloísa Navarro, David Ezpeleta, Jose Maria Mateos, Verónica García-Vázquez, Elena Martino, Manuel Desco,

Method for Accurate Brain Atrophy Follow-Up Using Functional Relaxometric Classification ...... 3931 J.B.M. Warntjes, J. West, P. Lundberg

Dynamic Contrast Enhanced MRI for Investigation of the Blood-Brain Barrier in an Experimental Model of Communicating Hydrocephalus ...... 3932 Laura Fanea, Shams Rashid, James P McAllister, Jie Li, Helene Benveniste, Mei Yu, Mark E. Wagshul

Reduced Resting CBF in the Mesolimbic-Frontal Regions in Parkinson’s Disease with Impulse Control Disorders...... 3933 Hengyi Rao, Eugenia Mamikonyan, John A. Detre, Andrew D. Siderowf, Matthew B. Stern, Daniel Weintraub

Effect of Dopaminergic Drugs on Motor and Speech Tasks in PD: An fMRI Study...... 3934 Mohit Saxena, Shanmugam Senthil Kumaran, Sumit Singh, Vaishna Narang, Madhuri Behari

An Analysis of Working Memory in Parkinson’s Disease with Reference to Deficiency of Dopamine: An fMRI Study ...... 3935 Mohit Saxena, Shanmugam Senthil Kumaran, Sumit Singh, Madhuri Behari

Brain Activation of Parkinson’s Patients During a Delayed Cued Finger Movement Task – a Preliminary Study...... 3936 Jing-Huei Lee, David M. Henkel, Judd M. Storrs, James C. Eliassen, Wen-Jang Chu, Noel Burton, Alberto J. Espay

Studying Functional Connectivity Strength Between the Primary Motor Cortex (PMC) and the Supplementary Motor Area (SMA) in Brain Tumor Patients Using Resting State BOLD fMRI ...... 3937 Bob Lei Hou, Bharat Biswal, Henning U. Voss, Nicole M. Petrovich Brennan, Kyung Peck, Andrei I. Holodny

Altered Resting State Networks in Patients with Cluster Headache ...... 3938 Massimo Filippi, Maria Assunta Rocca, Paola Valsasina, Bruno Colombo, Andrea Falini, Martina Absinta, Giancarlo Comi fMRI of Pain: An Analysis of the Benefits of Modelling Trial-To-Trial Pain Reports ...... 3939 Eugene P. Duff, Stephen M. Smith, Mark W. Woolrich, Bill Vennart, Matthew A. Howard, Steven C.R Williams, Steven J. Coen fMRI of Patients with Acute and Chronic Low Back Pain...... 3940 Harish A. Sharma, Gupta Rajshri, Emily Wee, Sarah Marner, William Olivero

Effective Connectivity Analysis of Emotional Processing in Remitted Depression ...... 3941 Nia Goulden, Shane McKie, Emma Pegg, Darragh Downey, Rebecca Elliott, Stephen Ross Williams,Ian M. Anderson, John Francis William Deakin

Predicting Treatment in Patients with Major Depression Using Granger-Based Connectivity and Support Vector Machines...... 3942 Gopikrishna Deshpande, George Andrew James, Richard Cameron Craddock, Helen S. Mayberg, Xiaoping P. Hu

Abnormal Neural Activity in Treatment-Resistant Depression: A Resting-State fMRI Study...... 3943 Qi-Zhu Wu, Dongming Li, Hong Yang, Long Chen, Xiuli Li, Fei Li, Nabin Amatya, Hehan Tang, Yu- Feng Zang, Qiyong Gong

Assessing Fit of Individuals to Group-Derived Structural Equation Models of Resting-State fMRI Data ...... 3944 George Andrew James, Richard Cameron Craddock, Mary Elizabeth Kelley, Paul E. Holtzheimer,Boadie Dunlop, Charles Nemeroff, Helen S. Mayberg, Xiaoping Phillip Hu

Morphological Changes in Brain During New Language Acquisition: A VBM Study ...... 3945 Shilpi Modi, Manisha Bhattacharya, Pawan Kumar, Subash Khushu

Indications of Residual Neurovascular Function in a Case of Hemianopia Prior to Visual Field Rehabilitation...... 3946 Yi-Ching Lynn Ho, Amandine Cheze, Lai-Hong Dennis Cheong, Esben Thade Petersen, Albert Gjedde, Kong-Yong Goh, Yih-Yian Sitoh, Xavier Golay

Increased Default Mode Activity in Patients with Progressive Supranuclear Palsy ...... 3947 Yu-Chun Lin, Tien-Min Liu, Chin-Song Lu, Yau-Yau Wai, Jiun-Jie Wang

A Voxel Based Morphometric Analysis of the Effect of Visual Experience on the Structural Organization of the Human Brain...... 3948 Manisha Bhattacharya, Shilpi Modi, Namita Singh Saini, Rajendra Prasad Tripathi, Subash Khushu

Full Brain Functional Connectivity of the Hippocampus in Temporal Lobe Epilepsy Compared to Controls ...... 3949 Victoria L. Morgan, Baxter P. Rogers, John C. Gore, Bassel Abou-Khalil

Impaired Functional Connectivity and Language in Non-Symptomatic Localization-Related Epilepsy ...... 3950 Jacobus F.A. Jansen, Marielle C. Vlooswijk, H J. Majoie, Paul A. Hofman, Marc C. de Krom, Albert P. Aldenkamp, Walter H. Backes

A Multimodal Imaging Approach to Surgical Planning in Temporal Lobe Epilepsy ...... 3951 Jodie Reanna Gawryluk, Ryan C. N. D'Arcy, David B. Clarke, Kimberly D. Brewer, Steven D. Beyea, R M. Sadler, Donald F. Weaver

The Default-Mode Network Is Selectively Altered in Temporal Lobe Epilepsy ...... 3952 Guangming Lu, Zhiqiang Zhang, Qifu Tan, Yuan Zhong, Yijun Liu

Neural Correlates of Amygdala Functional Connectivity on Abstinent Heroin Addicts ...... 3953 Yuan Ma, Chunming Xie, Wenjun Li, Lin Ma, Zheng Yang, Shi-Jiang Li

Abnormal Diffusion and Fractional Anisotropy in the Brains of Adolescent Methamphetamine Users ...... 3954 Christine C. Cloak, Daniel Alicata, Linda Chang, Joanna Ng, Thomas Ernst

Hippocampal Gray Matter of Cannabis Users Is Correlated with Cannabidiol Obtained from Hair Analysis ...... 3955 Traute Demirakca, Gabriele Ende, Alexander Sartorius, Nadja Meyer, Helga Welzel, Andreas Meyer-Lindenberg, Gisela Skopp, Karl Mann, Derik Hermann

Functional Connectivity Analysis of Heroin Addicts Using the Ventral Tegmental Area as a Seed ...... 3956 Alexander D. Cohen, Chunming Xie, Wenjun Li, Zheng Yang, Lin Ma, Shi Jiang Li

Hyperoxia Calibrated fMRI of Cerebral Small Vessel Disease During a Cognitive Stroop Task ...... 3957 Jonathan Goodwin, Guy Lumley, Andrew Irwin, Hedley Emsley, Laura Michelle Parkes

Hyperexcitability of the Motion-Sensitive Area MST in Migraineurs with Aura...... 3958 Peter Dechent, Katharina Saller, Carmen Morawetz, Jürgen Baudewig, Walter Paulus, Andrea Antal

Altered Functional Connectivity in the Pain Modulatory System of Migraineurs ...... 3959 Caterina Mainero, Nils Rettby, Thomas Benner, Nouchine Hadjikhani

Effective Connectivity of Resting State Networks in Patients Prenatally Exposed to Cocaine Shows Higher Emotional Arousal...... 3960 Gopikrishna Deshpande, Priya Santhanam, Zhihao Li, George Andrew James, Claire D. Coles, Mary Ellen Lynch, Stephen Hamman, Xiaoping P. Hu

Delayed Amygdala Response to Positive Emotional Stimuli in Major Depressive Disorder...... 3961 Qingwei Li, Chunbo Li, Wenyuan Wu, Yuan Shen, Peijun Wang, Gonghua Dai, Xuchu Weng, Yijun Liu

Altered Brain Connectivity with Hippocampus in Patients with Major Depressive Disorder ...... 3962 Junran Zhang, XiaoQi Huang, Su Liu, Qi-Zhu Wu, Dongming Li, Long Chen, Xiuli Li, Fei Li,Nabin Amatya, Hehan Tang, Weihong Kuang, QiYong Gong,

Resting State fMRI in Late-Life Anxious Depression ...... 3963 Minjie Wu, Carmen Andreescu, Jennifer Figurski, Costin Tanase, Howard J. Aizenstein,

Sensation Seeking and Aversive Stimulation - A Functional MRI Study at 3 Tesla...... 3964 Harald Kugel, Christina Sehlmeyer, Sonja Schoening, Maike Kleemeyer, Kristin Herper, Rauch Astrid, Hagen Schiffbauer, Bettina Pfleiderer, Volker Arolt, Pienie Zwitserlood, Walter Heindel, Carsten Konrad

Diffusion Tensor Imaging in Patients with Hallervorden-Spatz Syndrome and Their Siblings ...... 3965 Rishi Awasthi, Richa Trivedi, Vimal K. Paliwal, Jitesh K. Singh, Ram K S Rathore, Rakesh K. Gupta

Whole-Tract Reduction in Fractional Anisotropy in the Corticospinal Tracts of Amyotrophic Lateral Sclerosis Patients, as Measured Using a Weighted 3-D Region of Interest in Template Space After Deformable Diffusion Tensor Imaging Registration...... 3966 John H. Woo, Elias R. Melhem, Sumei Wang, Lauren Elman, Leo McCluskey, Lisa Desiderio, Hui Zhang, James Gee

Integrity of Limbic System Network in Schizophrenia: A Tract-Specific Analysis...... 3967 Akira Kunimatsu, Natsuko Kunimatsu, Shigeki Aoki, Osamu Abe, Yoshitaka Masutani, Hidenori Yamasue, Kiyoto Kasai, Harushi Mori, Daisuke Itoh, Kuni Ohtomo

Application of Canonical Correlation Analysis to Identify Regions of Significant Correlation Between Symptom Scores and DTI Measures in Schizophrenia...... 3968 Andrew Mario Michael, Vince D. Calhoun, Godfrey D. Pearlson, Stefi A. Baum, Arvind Caprihan

Static and Dynamic Visuomotor Task Performance in Children with Traumatic Brain Injury: A Diffusion Tensor Imaging Study...... 3969 Karen Caeyenberghs, Alexander Leemans, Bouwien Smits-Engelsman, Stephan Swinnen

Anatomic Vs. Functional MRI Seeding of the Corticospinal Tract in Patients with Brain Tumors ...... 3970 Robert J. Young, Tania Sierra, Valerie Lee, Nicole Brennan, Kyung Peck

Diffusion Tensor Imaging of Corticospinal Tract in Brain Neoplasms: Correlation with Motor Weakness ...... 3971 Naomi Morita, Sumei Wang, Paulomi Kadakia, Sanjeev Chawla, Myrna R. Rosenfeld, Donald M. O'Rourke, Harish Poptani, Elias R. Melhem

Diffusion Tensor Imaging Study of Patterns of Tract Involvement in Diffuse Pontine Gliomas...... 3972 Hoang-Vu Doan Tran, Matthew Scoggins, Robert Ogg, Nicholas Phillips, Kathleen Helton, Zoltan Patay, Alberto Broniscer, Claudia Hillenbrand

Perioperative Changes in Diffusion Tensor Imaging of White Matter in Patients with Brain Tumors...... 3973 Kyung K. Peck, Tania Sierra, Zhigang Zhigang, Raymond Baser, Rob Young

White Matter Damage in the Vegetative and Minimally Conscious States: Further Insights from Diffusion Tensor Imaging ...... 3974 Virginia Newcombe, Martin Coleman, Justin Cross, John Pickard, Guy Williams, David Menon

Diffusion Tensor Imaging Abnormalities in Children with Cerebellar Mutism After Posterior Fossa Tumor Resection...... 3975 Nicholas S. Phillips, E. Brannon Morris, Fred H. Laningham, Amar Gajjar, Robert J. Ogg

Diffusion Tensor Imaging of Deep Gray Matter in Children Receiving Brain Radiation Therapy ...... 3976 Anna E. Nidecker, Firouzeh Tannazi, Siamak Ardekani, Moody Wharam, Jr, Mark Mahone, Alena Horska

Measuring Diffusion Tensor Parameters in the Human Hippocampus: Region of Interest Placement...... 3977 Michael Yoong, Chris Clark, Rod Scott

Abnormal Diffusion Properties in a Rat Model of Dyslexia Revealed by Diffusion Spectrum Imaging (DSI) Tractography ...... 3978 Emi Takahashi, Glenn D. Rosen, Guangping Dai, Van J. Wedeen, Albert M. Galaburda, Ellen Grant

Comparison of White Matter in Normal and Dyslexic Children Using TBSS ...... 3979 Nancy Rollins, Michael Morriss, Jon Chia, Barjor Gimi, Jerry Wang

White Matter and Cortical Abnormalities in Williams Syndrome Detected by Diffusion Tensor Imaging ...... 3980 Andreia Vasconcellos Faria, Barbara Landau, Kirsten O'Hearn, Jiangyang Zhang, Kenishi Oishi, Xin Li, Hangyi Jiang, Kazi Akhter, Koji Sakai, Peter van Zijl, Susumu Mori, Michael I. Miller

Diffusion Tensor Imaging Tractography of the Corticosomatosensory Pathway in Painless Diabetic Neuropathy ...... 3981 Michael E. Hutton, Dinesh Selvarajah, Soloman Tesfaye, Iain D. Wilkinson

Diffusion Anisotropy Changes in Comatose Cardiac Arrest Patients...... 3982 Ona Wu, A Gregory Sorensen, Thomas Benner, Karen L. Furie, David M. Greer

Treatment-Induced Structural Changes in Cerebral White Matter and Its Correlation with Impaired Cognitive Functioning in Breast Cancer Patients...... 3983 Sabine Deprez, Judith Verhoeven, Mathieu Vandenbulcke, Frederik Amant, Refika Yigit, Joris Vandenberghe, Marie-Rose Christiaens, Caroline Sage, Ronald Peeters, Alexander Leemans, Wim Van Hecke, Stefan Sunaert

Neurocognitive Dysfunction in Chornic Kidney Disease (CKD) Patients -Correlations with DTI...... 3984 Jiachen Zhuo, Stephen Seliger, David Lefkowitz, Joshua Betz, Steven Roys, Rao Gullapalli

Effects of Brain Tumor on Corticospinal Tract and Motor Function: Analysis of Tract Stretch Using Diffusion Spectrum Imaging Tractography ...... 3985 Yu-Yang Yeh, Su-Chun Huang, W-Y. Chiang, F-C. Yeh, J-C. Tsai, H-M. Tseng, Wen-Yih I. Tseng

Effects of Brain Tumor on Corticospinal Tract and Motor Function: Diffusion Spectrum Imaging Tractography Analysis of Generalized Fractional Anisotropy ...... 3986 Yu-Yang Yeh, Su-Chun Huang, W-Y. Chiang, F-C. Yeh, J-C. Tsai, H-M. Tseng, Wen-Yih I. Tseng

Somatotopic Organization of Hand- Feet- Lips- And Tongue-Related Fibres Identified by fMRI and DTI in Controls and Patients with Brain Tumours ...... 3987 Laura Mancini, Neven Moustafa Hazzaa, Mario Miranda, John S. Thornton, Tarek Yousry

Probabilistic Tractography of Cerebellar-Cerebral Connections in Paediatric Brain Tumor Patients ...... 3988 Donald Mabbott, Conrad Rockel, Nadia Scantlebury, Nicole Law, Eric Bouffet

A Diffusion Tensor Imaging Study of White Matter Integrity in Adult Major Depressive Disorder ...... 3989 Zhiyun Jia, Xiaoqi Huang, Tijiang Zhang, Qizhu Wu, Su Lui, Huijie Li, Nabin Amatya, Xiuli Li, Weihong Kuang, Qiyong Gong

Localization and Quantification of Injured Regions and Affected Pathways in the 3D Head-Space of Individual TBI Subjects Using DTI Tractography with Automatically Generated ROIs ...... 3990 Manbir Singh, Jeong-Won Jeong

7T DTI in Mild Traumatic Brain Injury Patients and Age Matched Controls...... 3991 Seongjin Choi, Jennifer Bogner, John Corrigan, Walter Mysiw, Dustin Cunningham, Cherian Renil Zachariah, Steffen Sammet, Devin Prior, Donald Chakeres, Michael Vincent Knopp, Petra Schmalbrock

Pericontusional and Contalateral Tissue Show Differential Metabolism and Perfusion Changes After Traumatic Brain Injury ...... 3992 Kristine O'Phelan, Dalnam Park, Thomas Ernst, Andrew Stenger, Steven Buchthal, Renat Yakupov, Linda Chang

DTI Reveals Disease Severity Specific Nerve Fiber Impairment in Juvenile Myoclonic Epilepsy ...... 3993 Michael Deppe, Christoph Kellinghaus, Thomas Duning, Gabriel Möddel, Siawoosh Mohammadi, Katja Deppe, Harald Kugel, Simon S. Keller, E. Bernd Ringelstein, Stefan Knecht

White Matter Tractography by Diffusion Tensor Imaging in Insular Epilepsy ...... 3994 Hesamoddin Jahanian, Kost Elisevich, Azadeh Yazdan-Shahmorad, Hamid Soltanian-Zadeh

A Disproportionate Role for the Fornix in Recall Rather Than Recognition Memory - Tractography Evidence in Temporal Lobe Epilepsy...... 3995 Mahinda Yogarajah, Niels Focke, Silvia Bonelli, Geoff Parker, Daniel Alexander, Pamela Thompson, Mark Symms, Matthias Koepp, John Duncan

Tractography in the Fetal Brain with Correction of Fetal and Maternal Motion Using Model-Based Slice to Volume Registration...... 3996 Alvaro Bertelsen, Serena Counsell, Joanna Allsop, Amy McGuinness, Shuzhou Jiang, Rita Nunes, Paul Aljabar, Daniel Rueckert, Mary R. Rutherford, Joseph V. Hajnal

Characterizing Neuronal Morphological Development Using Diffusion Tensor Imaging...... 3997 Lindsey A. Leigland, Sune N. Jespersen, Erin N. Taber, Anda Cornea, Christopher D. Kroenke

DTI Study of Cerebral White Matter Development in Preterm Children at Preadolescent Ages to Examine Persisting Changes...... 3998 Lutfi Tugan Muftuler, Elysia Poggi Davis, Curt A. Sandman, Orhan Nalcioglu, James Fallon

White Matter Changes in Lipopolysaccharide Treated Fetal Sheep Measured by High-Field Diffusion Tensor Imaging ...... 3999 Yohan van de Looij, Justin M. Dean, Grégory Lodygensky, Henrik Hagberg, Petra S. Hüppi, Carina Mallard, Rolf Gruetter, Stéphane V. Sizonenko

Measurement of Brain Development in the First Two Years of Life...... 4000 Feng Shi, Yong Fan, Songyuan Tang, John Gilmore, Weili Lin, Dinggang Shen

Longitudinal Diffusion Tensor Imaging of Healthy Brain Development in Children...... 4001 Catherine Lebel, Christian Beaulieu

Study of the Development of Major Cerebral Fiber Bundles and Its Lateralization from Birth to Adulthood Using Quantitative Diffusion Tensor Tractography (DTT)...... 4002 Richa Trivedi, Gyanendra K. Malik, Shruti Agarwal, Sona Saksena, Ram K S Rathore, Rakesh K.Gupta

Regional Age Related Changes in Fractional Anisotropy of the Brain in Cognitively and Developmentally Normal Children and Adolescents Using Diffusion Tensor Imaging and Tract Based Spatial Statistics (TBSS) at 3T...... 4003 Michael Craig Morriss, Jerry Wang, Jonathan M. Chia, Barjor Gimi, Nancy K. Rollins

A Pediatric Brain Template for Diffusion Tensor Imaging...... 4004 Zhiyue J. Wang, Jonathan M. Chia, Michael C. Morriss, Hao Huang, Barjor Gimi, Nancy K. Rollins

Construction of a DTI Atlas of the Healthy Human Brain with Diffusion Full Tensor Information in ICBM-81 Space: An Application for Studying the Maturation of White Matter ...... 4005 Judith Verhoeven, Caroline A. Sage, Sabine Deprez, Paul De Cock, Lieven Lagae, Alexander Leemans, Wim Van Hecke, Stefan Sunaert

Enhancement of FA in Child`s Brain After Long-Term Abacus Mental Calculation Training ...... 4006 Yuzheng Hu, Fengji Geng, Feiyan Chen

Comparison Analysis Between Patients with Seizures and Developmental Delay: A Multiple Modality Study...... 4007 Zili Chu, Elisabeth A. Wilde, Xiaoqi Li, Jill V. Hunter,

Role of DTI in Understanding Pathophysiology and Assessing TherapeuticResponse in Patients with Tuberculous Meningitis (TBM) ...... 4008 Abhishek Yadav, Chaynika Chaudhry, Anuradha HK, Atul Agrawal, Sanjay Verma, Ram K S Rathore,Rakesh K. Gupta

Abnormal Age-Related Changes in Diffusion and Anisotropy in the Thalamus and Genu Suggest Abnormal Brain Development in Infants Exposed to Stimulants in Utero ...... 4009 Lynn Michelle Anderson, Linda Chang, Steven Buchthal, Christine Cloak, Aaron Hoo, Brian Keating, Jeffrey Sadino, Thomas Ernst

Diffusion Tensor Imaging of Rett Syndrome ...... 4010 Aigerim Djamanakova, SakkuBai Naidu, Genila Bibat, Kenichi Oishi, Andreia V. Faria, Xin Li, Michael I. Miller, Peter van Zijl, Susumu Mori

Diffusion Tensor Imaging Correlates of Mathematical Ability in Children with Fetal Alcohol Spectrum Disorder...... 4011 Catherine Lebel, Carmen Rasmussen, Katy Wyper, Gail Andrew, Christian Beaulieu

Increased Cost Efficiency of Economical Brain Structural Networks in the Early Developing Brain...... 4012 Yong Fan, Feng Shi, John Gilmore, Weili Lin, Dinggang Shen

Frequency Dependence of the Developing Brain Functional Network: MRI-EEG?...... 4013 Wei Gao, Hongtu Zhu, Kelly Giovanello, Keith Smith, Dinggang Shen, John Gilmore, Weili Lin

Emergence of the Brain's Default Network: Evidence from Two-Week-Old to Four-Year-Old Healthy Pediatric Subjects...... 4014 Wei Gao, Hongtu Zhu, Kelly Giovanello, Keith Smith, Dinggang Shen, John Gilmore, Weili Lin fMRI of Very Premature Infants (<32 Weeks GA) at Birth...... 4015 Wayne Lee, Drew Morris, Revital Nossin-Manor, Elizabeth J. Donner, John G. Sled, Margot J. Taylor, Hilary E.A. Whyte

Somatosensory Cortical Activation in the Preterm Brain Identified with a Programmable Hand Interface and Functional MRI ...... 4016 Tomoki Arichi, Alejandro Melendez, Amelie Moraux, Valentina Doria, Etienne Burdet, Christian F. Beckmann, D J. Larkman, A D. Edwards

Improved Slice to Volume Reconstruction of the Fetal Brain for Automated Cortex Segmentation...... 4017 Alvaro Bertelsen, Paul Aljabar, Hui Xue, Latha Srinivasan, Tayyib Hayat, Joanna Allsop, Daniel Rueckert, Mary R. Rutherford, Joseph V. Hajnal

Automatic Neonatal Brain Segmentation for Nine Tissue Types Simultaneously ...... 4018 Petronella Anbeek, Britt van Kooij, Floris Groenendaal, Linda S. de Vries, Max A. Viergever, Manon J. Benders

Automatic Regional Segmentation of Newborn Brain MRI Using Mathematical Morphology on Dual Contrast...... 4019 Radoslaw Lisowski, Francois Lazeyras, Petra Susan Hüppi, Michel Kocher

In-Vivo Proton Magnetic Resonance Spectroscopy (PMRS) Changes in Extra-Hepatic Portal Vein Obstruction (EHPVO) Induced Hepatic Encephalopathy (HE) Are Different from Chronic Liver Disease (CLD)...... 4020 Santosh K. Yadav, Anshu Srivastava, Arti Srivastava, Michael Albert Thomas, Surender K. Yaccha, Richa Lal, Rakesh K. Gupta

J-Difference Editing Method to Evaluate GABA May Reveal the Mechanism of ACTH Therapy for Infantile Spasms as a Useful Predict Biomarker...... 4021 Ayumi Nose, Masafumi Harada, Hitoshi Kubo, Kenji Mori, Tsuyoshi Matsuda, Hiromu Nishitani

Functional MRI in Pediatric Cancer Survivors During Cognitive Remediation...... 4022 Ping Zou, Raymond Mulhern, Robert Butler, Robert Ogg

Nature Vs Nurture in Newborn Voice Perception. an fMRI Comparison of Auditory Processing Between Premature Infants at Term Age and Term Born Neonates...... 4023 Stephane Simon, François Lazeyras, Alain-Dominique Sigrist, Marc Ecoffey, Stefano Guatieri, Dimitri Van De Ville, Cristina Borradori Tolsa, Marco Pelizzone, Petra Hüppi

Abnormalities in Regional Brain Volumes in Adolescent Methamphetamine Users ...... 4024 George Russell King, Dan Alicata, Christine Cloak, Thomas Ernst, Irene Chin, Linda Chang

Systematic Investigation of Volume Changes Induced by Prenatal Alcohol Exposure in Cortical and Sub-Cortical Regions...... 4025 Xiangchuan Chen, Mary E. Lynch, Xiaoping Hu, Claire D. Coles

Changes in NAA and Presence of Lactate on MRS Predict Outcome in Children with Nonaccidental Trauma ...... 4026 Barbara Holshouser, Gregory Aaen, Clare Sheridan, Melinda McKenney, Udo Oyoyo, Stephen Ashwal

Susceptibility Weighted Imaging: Microhemorrhage Prevalence and Prediction of Long Term Outcome in Pediatric Non-Accidental Brain Trauma (NAT) ...... 4027 B. Holshouser, C. Colbert, G. Aaen, C. Sheridan, D. Kido, S. Ashwal

Putative Links Between Fronto-Striato-Thalamic Pathways and Behavioral Phenotype in Children with Tourette Syndrome...... 4028 Malek I. Makki, Rajkuma Munina-Govindan, Benjamin Wilson, Michael E. Behen, Harry T. Chugani

Longitudinal Evaluation of Lactate in Children with Autism Disorder Using MR Spectroscopic Imaging...... 4029 Neva M. Corrigan, Todd L. Richards, Helen Petropoulos, Seth D. Friedman, Stephen R. Dager,

Abnormal Cortical and Subcortical Water Diffusivity Measured in Children with Tourette Syndrome...... 4030 Malek I. Makki, Benjamin J. Wilson, Rajkumar Munian Govindan, Michael E. Behen, Harry T. Chugani

Comparison of Group Average and Individual Differences in Brain Morphometry in Williams Syndrome...... 4031 Zhaoying Han, Tricia Thornton-Wells, Elisabeth Dykens, Anuj Srivastava, Zhaohua Ding, John C. Gore, Benoit Dawant

Perfusion Deficit in Schizophrenia and Correlation with Psychopathological Symptoms ...... 4032 Jinsoo Uh, Perry Mihalakos, Carol A. Tamminga, Hanzhang Lu

Short-Term Follow Up Study of Grey Matter Volume Changes in Antipsychotic- Naïve First Episode Schizophrenia: An Optimized VBM Study ...... 4033 Ling Zou, Deng Wei, He-Han Tang, Li-Jun Jiang, Wei Yi, Dong-Ming Li, Xiu-Li Li, Fei Li, Su Lv,Xiao-qi Huang, Tao Li, Qi-Yong Gong

Correlation Among in Vivo 1H-MRS Metabolic Profiles, Genetic and Clinical Data in Schizophrenic Patients...... 4034 Bernardo Celda, Beatriz Martinez-Granados, MCarmen Martinez-Bisbal, Olga Brotons, Eduardo J.Aguilar, Luis Marti-Bonmati, Rosa de Frutos, Olga Rivero, Julio Sanjuan

Evidence for Top-Down Dysregulation of Primary Visual Processes in Children and Adolescents with Schizophrenia...... 4035 Tonya White, Marcus N. Schmidt, Steen Moeller

Working Memory Load-Related Brain Activity in Drug-Naïve, First-Episode Schizophrenia Patients ...... 4036 Ayna Baladi Nejad, Bjørn Hylsebeck Ebdrup, Birte Glenthøj, William Baaré

Assessment of GABA and Glutamate/Glutamine at 3.0 T in Chronic Fatigue Syndrome, Major Depressive Disorder and Healthy Volunteers ...... 4037 Chris Kelly, Sanjay Johann Mathew, Xiangling Mao, Gizely Andrade, Rebecca B. Price, Paul S. Nestadt, Susan M. Levine, Dikoma C. Shungu

Cross-Sectional Grey Matter Metabolic Correlation in Adolescent with Obsessive- Compulsive Disorder and a Subgroup of Anorexia Nervosa by 1H-MR Spectroscopy ...... 4038 Ana Isabel Garcia, Luisa Lázaro, Josefina Castro-Fornieles, Susana Andrés, Carles Falcón, Nuria Bargalló

Macrostructural and Microstructual Abnormalities of the Neurocircuitry in Bipolar Disorder: A Study of Structural MR and Diffusion Tensor Imaging Data ...... 4039 Ping-Hong Yeh, E. Serap Monkul, Mark A. Nicoletti, John P. Hatch, Fabiano G. Nery, Jack Lancaster, Jair C. Soares

Imaging the Functional Pathology in ApoE 4 Carriers by the Hippocampus Functional Connectivity ...... 4040 Chunming Xie, Wenjun Li, Piero Antuono, Jennifer Jones, Zhilin Wu, Shi-Jiang Li

Plugged in and Switched On. the Effect of Acute Transcranial Direct Cortical Stimulation on Brain Metabolites in Healthy Controls...... 4041 Caroline Rae, Patrick Arul-Anandam, Kirsten Moffat, Colleen Loo

Latent Volumetric Structure of Gray Matter in Adolescent Bipolar Disorder Using Factor Analysis and Structural Equation Modeling ...... 4042 Ping-Hong Yeh, Mark Nicoletti, Hongtu Zhu, Hasan Baloch, John Hatch, Giovana Zunta-Soares, Jair C.Soares

White Matter Lesions and Cerebral Perfusion Imaging in Late-Onset Major Depression...... 4043 Rikke Beese Dalby, Jamila Ahdidan, M. Mallar Chakravarty, Leif Sørensen, Raben Rosenberg, Leif Østergaard, Poul Videbech

White Matter Integrity Measured by Fractional Anisotropy Is Associated with Reading Ability in Pediatric Brain Tumor Patients: A Voxel Based Analysis Study of Cognitive Outcome ...... 4044 John O. Glass, Shawna L. Palmer, Wilburn E. Reddick, Dana Wallace, Nicholas S. Phillips, Robert J. Ogg, Amar Gajjar

A Multicentre Study of 1H MRS for the Characterisation of Low Grade Brain Tumours of Childhood ...... 4045 Eleni Orphanidou-Vlachou, Dorothee Auer, Jonathan Coupland, Nigel P. Davies, Tim Jaspan, Lesley McPherson, Kal Natarajan, Dawn Saunders, Yu Sun, Theodoros Arvanitis, Richard Grundy, Andrew Peet

Susceptibility Weighted Imaging (SWI) in Children with Brain Stem Glioma During Combined Antiangiogenic and Radiation Therapy...... 4046 Jan Sedlacik, Hoang-Vu Tran, Ulrike Löbel, Ralf Löffler, Jürgen Reichenbach, Alberto Broniscer,Zoltan Patay, Claudia M. Hillenbrand

Assessment of Vascular Supply of Hypervascular Extra-Axial Brain Tumors with MR Regional Perfusion Imaging at 3T ...... 4047 Akira Sasao, Toshinori Hirai, Shinichiro Nishimura, Mika Kitajima, Ryuji Murakami, Motohiro Morioka, Shigetoshi Yano, Jun-ichi Kuratsu, Yasuyuki Yamashita

Functional Diffusion Tensor Imaging in the Evaluation of Early Response After Radiosurgery in Patients with Acoustic Neuroma ...... 4048 Yu-Chun Lin, Yau-Yau Wai, Chun-Chieh Wang, Jiun-Jie Wang

Effects of the Intravenous Contrast Agent of GD-DTPA on Time Dependent DTI on Patients with Brain Tumors ...... 4049 Min Sun Bae, Geon-Ho Jahng, Chang Woo Ryu, Hyun Cheol Kim, Dal Mo Yang, Eui Jong Kim, Woo Suk Choi

Multispectral Analysis of Magnetic Resonance Images for Glioma Grading...... 4050 Benjamín Garzón, Kyrre E. Emblem, Kim Mouridsen, Atle Bjørnerud, Asta Håberg, Yngve Kvinnsland

Role of Functional Diffusion Maps as an Imaging Biomarker for Treatment Response Assessment in Recurrent/progressive Malignant Gliomas Treated with Bevacizumab...... 4051 Rajan Jain, Shehanaz Ellika, Lisa Scarpace, Roy Torcuator, Lonni Schultz, David Hearshen, Tom Mikkelsen

Evaluating Anti-Angiogenic Therapy Response in Patients with GBM Using Homodynamic Response Imaging...... 4052 Dafna Ben-Bashat, Haim Ben-Ami, Moran Artzi, Deborah Blumenthal, Felix Bokstein, Orna Aizenstein, Yifat Edrei, Ben Corn, Rinat Abramovitch

Combining fMRI, Diffusion Tensor Tractography and Time-Resolved MRA in Pre-Operative Surgical Planning for Brain Tumors...... 4053 Zhitong Zou, Lin Ma, Xianghui Meng

Therapy Response in Glioblastoma Multiforme Evaluated with Diffusion/perfusion MRI ...... 4054 Beatrice Rositta Persson, Elena Steffensen, Mats Holmberg, Elna-Marie Larsson

The ETUMOUR Database: A Tool for Annotation and Curation of Multidimensional Human Brain Tumor Data ...... 4055 Margarida Julià-Sapé, Mariola Mier, Miguel Lurgi, Francesc Estanyol, Xavier Rafael, Teresa Delgado-Goñi, Miriam Camisón, M. Carmen Martinez-Bisbal, Bernardo Celda, Carles Arús, C. Etumour

Correlations with Gene Expression Profile May Generate New MR Spectroscopy Markers for Glioblastoma Prognosis and Treatment Planning ...... 4056 Alan James Wright, Greg Fellows, Ken Laing, John Griffiths, Brian Anthony Bell, Franklyn Arron Howe

TumourClassifier, a Java Tool for Fast Development and Implementation of MRSBased Classifiers...... 4057 Sandra Ortega-Martorell, Ivan Olier, Margarida Julia-Sape, Carles Arus

Differentiating Tumour vs. Pseudotumoural Disease vs. Normal Brain with SV 1HMRS...... 4058 Margarida Julià-Sapé, Carles Majós, Mònica Cos, Carles Aguilera, Carles Arús

In Vivo 1H MRS, Ex Vivo HR-MAS and Genetic Biomarkers for Oligodendroglial Tumours Differentiation...... 4059 Bernardo Celda, Ruben Ferrer-Luna, Horacio Marinetto, Jorge Calvar, Gustavo Sevlever, Mcarmen Martinez-Bisbal, JoseM Morales, Daniel Monleon

HR-MAS Spectroscopic Analysis of Biopsies of Thyroid Tumors; a Pilot Study ...... 4060 Poonam Verma, R K. Singh, R Ramakant, Suresh Kumar, Surendra kumar, Nuzhat Husain, Raja Roy

Investigating the ADC Value of Neoplasm Involving the Pharynx and Oral Cavity...... 4061 Chun-Jung Juan, Cheng-Yu Chen, Hing-Chiu Chang, Chun-Jen Hsueh, Hung-Wen Kao, Hua-Shan Liu, Hsiao-Wen Chung, Guo- Shu Huang

Imaging Distortion and Quantification Bias of Parotid ADC Measurements in EPDWI and Fast Spin-Echo PROPELLER-DWI...... 4062 Chun-Jung Juan, Hing-Chiu Chang, Chun-Jen Hsueh, Hua-Shan Liu, Cheng-Yu Chen, Hsiao-Wen Chung, Tzu-Chao Chuang, Hung-Wen Kao, Guo-Shu Huang

Quantification of Parotid Fat Content and ADC Using IDEAL Gradient Echo Imaging and PROPELLER-DWI ...... 4063 Chun-Jung Juan, Hing-Chiu Chang, Yin-Cheng Kris Huang, Hua-Shan Liu, Chun-Jen Hsueh,Cheng-Yu Chen, Hung-Wen Kao, Hsiao-Wen Chung, Guo-Shu Huang

Carotid Intima-Media Thickness and Distensibility Measured by MRI at 3T Versus High-Resolution Ultrasound...... 4064 Andreas Harloff, Timo Zech, Alex Frydrychowicz, Martin Schumacher, Joachim Schöllhorn, Jürgen Hennig, Cornelius Weiller, Michael Markl

MR Imaging of Carotid Plaque: Correlation Between Contrast-Enhancement and Inflammation at Histopathology...... 4065 Francesco Sardanelli, Giacomo Davide Edoardo Papini, Stefania Tritella, Biagio Cotticelli, Giovanni Nano, Claudio Clemente, Giovanni Di Leo

Non-Contrast-Enhanced MR Angiography of the Carotid Arteries and Aortic Arch Using Inherent Enhancement (Inhance) Inflow IR, Adopting Peripheral-Gated Partial-Fourier Fast Spin Echo (FSE) or Steady-State Free Precession (FIESTA) : A Comparison with Contrast MRA...... 4066 Kimihiko Sato, Takayuki Masui, Motoyuki Katayama, Hiroki Ikuma, Hidekazu Seo, Akihiko Kutsuna, Megumi Ishii, Masayoshi Sugimura, Naoyuki Takei, Mitsuharu Miyoshi, Tetsuji Tsukamoto, Kenji Asano

Nonenhanced Time-Resolved MRA Using Inflow Arterial Spin Labeling ...... 4067 Shinichi Kitane, Tokunori Kimura, Yuichi Yamashita, Mitsue Miyazaki

Blood Vessel Contrast Enhancement Using Phase Corrected Real Imaging in Flow-Sensitive Black Blood Imaging...... 4068 Tokunori Kimura, Masato Ikedo

Detection of 100% Oxygen Induced Changes in Retina Using Magnetic Resonance Imaging: A Human Study ...... 4069 Xu Qinggang, Chen Qinghua, Wang Zhenchang, Xian Junfang

Delineation of Draining Veins in Arteriovenous Malformations on Susceptibility Weighted Imaging: Impact of Magnitude Images ...... 4070 Toshiteru Miyasaka, Toshiaki Taoka, Toshiaki Akashi, Kaoru Myouchin, Masahiko Sakamoto,Katsutoshi Takayama, Horoyuki Nakagawa, Kimihiko Kichikawa

TOF-MRA Measurements of Cranial Arteries in Cholesterol-Fed Rabbits...... 4071 Susan K. Lemieux, Carrie A. Smith-Bell, Jeffrey S. Carpenter, Bernard G. Schreurs

Simultaneous Measurement of Glutathione and Other Metabolites in Stroke Patients by J-Difference Spectroscopy...... 4072 Li An, Larry L. Latour, Krishna A. Dani, Jun Shen, Steven Warach

Sodium MRI of Core and Penumbra in Ischemic Stroke Patients ...... 4073 Adrian Tsang, Rob Stobbe, Ken Butcher, Shazam Hussain, Yusuf Bhagat, Derek Emery, Christian Beaulieu

Diffusional Kurtosis Imaging in Acute Human Stroke ...... 4074 Joseph A. Helpern, Calvin Lo, Caixia Hu, Maria F. Falangola, Otto Rapalino, Jens H. Jensen

Evaluation of the SWAN Pulse Sequence: A Novel Technique for Susceptibility Enhanced Imaging...... 4075 David W. Stanley, E Paul Lindell, John D. Port, Norbert G. Campeau, Heidi A. Ward, Marilyn R. Wood, Ravi Bhardwaj, Anthony T. Vu

Susceptibility Weighted MRI of Ferumoxytol at 3T and 7T in Human Brain...... 4076 John Grinstead, Seymur Gahramanov, Csanad Varallyay, Vladimir Jellus, Edward A. Neuwelt, William D. Rooney

High Contrast and High Resolution in Vitro Susceptibility Weighted Imaging (SWI) at 7 Tesla...... 4077 Guenther Grabner, A-M van Cappellen van Walsum, Siegfried Trattnig, Markus Barth

Gradient Echo Versus Spin Echo T2-Weighted Imaging of Deep Brain Structures of the Human Brain at 7 Tesla...... 4078 Stephane Lehericy, Eric Bardinet, Jerome Yelnik, Fabrice Poupon, Kamil Ugurbil, Pierre-Francois Van de Moortele, Cyril Poupon

Resolving White Matter Structures of Human Hippocampus in Vivo with High Resolution DTI at 3 T...... 4079 Dimitrios C. Karampinos, Anh T. Van, Brian D. Gonsalves, John G. Georgiadis, Bradley P. Sutton

Ultra-High Resolution 7.0T MRI of Medial Temporal Lobe Epilepsy...... 4080 Michael Maroun Zeineh, Josef Parvizi, Priti Balchandani, Chunlei Liu, Gary Glover, Anne Sawyer,Robert Fisher, Scott William Atlas

Comparison of SNR and Contrast in FLAIR at 3T and 7T...... 4081 Jaco J.M. Zwanenburg, Fredy Visser, Jerhoen Hendrikse, Taro Takahara, Peter R. Luijten

Attenuation of Cerebral Venous Contrast in Susceptibility Weighted Imaging (SWI) in Pediatric Patients Under General Anesthesia...... 4082 Jan Sedlacik, Ulrike Löbel, Alberto Broniscer, Zoltan Patay, Claudia M. Hillenbrand

Anatomical Identification of V5 in Humans at 7 T...... 4083 Robert Trampel, Robin Heidemann, Dimo Ivanov, Robert Turner

Diagnosis of Dental Abnormalities in Children Using MRI ...... 4084 Olga Tymofiyeva, Kurt Rottner, Peter Christian Proff, Ernst-Juergen Richter, Peter Michael Jakob

MRI as a Diagnostic Tool in Conservative Dentistry ...... 4085 Olga Tymofiyeva, Julian Boldt, Kurt Rottner, Ernst-Juergen Richter, Peter Michael Jakob

Dental Restorations – Crowns, Bridges and Inlays – Produced Using in Vivo Dental MRI...... 4086 Olga Tymofiyeva, Kurt Rottner, Julian Boldt, Ernst-Juergen Richter, Peter Michael Jakob

3D Visualization of Endolymphatic Hydrops After Intratympanic Injection of Gd- DTPA; Optimization of 3D- Real IR TSE Sequence and Utilization of 32ch Head Coil at 3T...... 4087 Shinji Naganawa, Minako Kawamura, Tsutomu Nakashima

T1 and Volumetric Q-MRI of the Major Salivary Glands: Effects of Aging (Preliminary Results in 41 Subjects Over the Human Lifespan)...... 4088 Naoko Saito, Hernan Jara, Osamu Sakai

7 Tesla in Vivo of the Human Eye: A SNR and CNR Optimization Study...... 4089 Peter A. Wassenaar, Kathryn Richdale, Katharine Teal Bluestein, John Christoforidis, Titus Lanz, Michael Vincent Knopp, Petra Schmalbrock

High Resolution MRI and CT Investigation of Laryngeal Soft Tissues and Skeletal Structures ...... 4090 Michael Hofer, Bernhard Neumayer, Markus Gugatschka, Philipp Juergens, Rudolf Stollberger, Erich Sorantin, Franz Ebner, Gerhard Friedrich, Claudio Storck

A Method for MR Imaging of Head and Neck Cancer Patients in the Radiotherapy Treatment Position Without Loss of Image Quality ...... 4091 Scott Hanvey, John Foster, Martin Glegg

Estimation of Local Tissue Diffusion Anisotropy with Hyperecho Coherence Pathway Selective (HyperCOPS) Diffusion Tensor Imaging...... 4092 Lawrence R. Frank, J Michael Tyszka

Optimization of Diffusion Encoding Gradients in Axisymmetric Diffusion Tensor Imaging Using A Priori Structure Information...... 4093 Shantanu Majumdar, David C. Zhu, Guy Raguin, Satish S. Udpa

Reduction of Signal Loss in Diffusion-Weighted Imaging of the Upper Abdomen: motion Correction Using Bipolar Motion Probing Gradients...... 4094 Isao Muro, Tetso Ogino, Tomohiko Horie, Taro Takahara, Thomas Kwee, Yutaka Imai, Marc Van Cauteren

Study of Aliasing Error with SENSE in Body Diffusion Image Using Single Shot EPI at 3T...... 4095 Isao Muro, Tomohiko Horie, Yutaka Imai

Robust Diffusion-Weighted Imaging Using Split-Blade PROPELLER and LRX Phase Modulation ...... 4096 Zhiqiang Li, Xiaoli Zhao, Donglai Huo, James Pipe, Patrick Le Roux

Diffusion-Weighted PROPELLER with a Novel Unaliasing Technique for Small Field of View Imaging ...... 4097 Zhiqiang Li, Donglai Huo, Xiaoli Zhao, Ajeetkumar Gaddipati, James Pipe

PROPELLER DUO: Applied to Diffusion-Weighted Imaging ...... 4098 Xiaoli Zhao, Zhiqiang Li, Ajeetkumar Gaddipati

New Horizons in Diffusion Weighted Imaging: A Comprehensive Evaluation of a Fast Spin Echo DWI Sequence with Radial K-Space Sampling at 3T Using a 32-Channel Head Coil in Acute Brain Ischemia...... 4099 Ulrike Irmgard Attenberger, Val M. Runge, K D. Williams, Alto Stemmer, Henrik J. Michaely, Stefan O. Schoenberg, Maximilian F. Reiser, Bernd J. Wintersperger

Measuring Small Compartmental Dimensions with Low-Q Angular Double-PGSE NMR ...... 4100 Noam Shemesh, Evren Özarslan, Peter J. Basser, Yoram Cohen

Partial Volume Averaging and Contrast-To-Noise Ratios in Diffusion Tensor MRI: Effects of Using Multiple B- Values...... 4101 Marta Morgado Correia, Virginia FJ Newcombe, Thomas Adrian Carpenter, Guy B. Williams

Diffusion-Sensitive Single-Shot Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) in Human Brain...... 4102 Stefan Posse, Akio Ernesto Yoshimoto, Ricardo Otazo, Andre van der Kouwe, Fa-Hsuan Lin, Lawrence L. Wald

Do We Need Cardiac Gating in Brain-DTI at High (3T) and Ultra-High (7T) Field Strengths?...... 4103 Josef Habib, Richard Bowtell, Dorothee P. Auer, Paul S. Morgan

Stimulated-Echo DTI with Magnetization Transfer Contrast for Myelin Specificity...... 4104 Alexandru Vlad Avram, Arnaud Guidon, Allen W. Song

Discarded Image Volumes and Gradient Table Alignment: How Much Do They Affect DTI Tensor Calculations? ...... 4105 Lutfi Tugan Muftuler, Orhan Nalcioglu

Non-Gaussian Diffusion MR Maps of Human Brain ...... 4106 Silvia De Santis, Silvia Capuani

Does Kurtosis or Stretched-Exponential Model Fit Experimental Diffusion-Weighted Data Better? ...... 4107 Edward S. Hui, Abby Y. Ding, Ed X. Wu,

Anatomical Cortico-Cortical Networks of the Human Brain Based on Diffusion Probabilistic Tractography ...... 4108 Ruiwang Huang, N Jon Shah, Lars Hoemke, Oleg Posnansky, Karl Zilles, Katrin Amunts

Feasibility of Prefronto-Caudate Pathway Tractography Using High Resolution Diffusion Tensor Tractography Data at 3 T...... 4109 Arash Kamali, Larry A. Kramer, Khader M. Hasan

Kiss to Cross ! Non-Invasive Mapping of Cerebellar Dentate Nucleus Projections to the Cerebral Cortex ...... 4110 Vinod Kumar, Michael Erb, Sudhir Pathak, Wolfgang Grodd

In Vivo Diffusion Spectrum Imaging Shows the Structural Basis of the “Papez Circuit” ...... 4111 Cristina Granziera, Reto Meuli, Gunnar Krueger

Diffusion Tensor Tractography of the Somatosensory System in the Human Brainstem: Initial Findings Using High Isotropic Spatial Resolution at 3.0 T...... 4112 Arash Kamali, Larry A. Kramer, Ian J. Butler, Khader M. Hasan

In Vivo Fiber Tracking in the Rabbit Brain on a Clinical 3T MRI System ...... 4113 Daniel Güllmar, Stephan Lau, Lars Flemming, Jens Haueisen, Jürgen R. Reichenbach

Addressing the Problem of Path-Length Dependency in Probabilistic Tractography – the ICE-T Framework...... 4114 Matthew George Liptrot, Karam Sidaros, Tim Bjørn Dyrby

Evaluation of DTI Tractography at Long and Short Diffusion Times in ex Vivo and in Vivo Rhesus Macaques...... 4115 Swati Rane, Timothy Q. Duong

High Resolution Ex-Vivo Diffusion Imaging and Fiber Tracking ...... 4116 Thomas Benner, Akram Bakkour, Ruopeng Wang, Bradford Clark Dickerson

ExploreDTI: A Graphical Toolbox for Processing, Analyzing, and Visualizing Diffusion MR Data...... 4117 Alexander Leemans, Ben Jeurissen, Jan Sijbers, Derek K. Jones

A Comparative Study Between 4 Optimal DWI Gradient Sampling Schemes: Simulations Based on Constrained Spherical Deconvolution (CSD) ...... 4118 Shiou-Ping Lee, Jacques-Donald Tournier, Christopher-P Hess, Chung-Ming Chen, Wen-Yih Isaac Tseng

Optimal Real-Time Q-Ball Imaging with Incremental Recursive Orientation Sets ...... 4119 Maxime Descoteaux, Jeff Calder, Cyril Poupon, Fabrice Poupon, Rachid Deriche

An Interface for DTI Tractography ...... 4120 Shruti Agarwal, Rakesh K. Gupta, RKS Rathore, Sanjay Kumar Verma, Richa Trivedi, Manoj Verma, Prativa Sahoo

Robust Extraction of Fiber Skeleton Based on Whole Fiber Tensor Information and Active Contour Method...... 4121 Wu Li, Xiaoping P. Hu

Diffusion Sensitization Direction Dependence of Biexponential Diffusion Decay Parameters in the Splenium...... 4122 Robert Vincent Mulkern, Richard Lee Robertson, Stephen John Haker, Dimitrios Mitsouras, Stephan E. Maier

White Matter Fiber Tractography with Genetic Algorithm ...... 4123 Xi Wu, Qing Xu, Jiliu Zhou, Adam W. Anderson, Zhaohua Ding

Estimation of Multiple Fibre Orientations Using Convex Optimization ...... 4124 Jaime E. Cisternas, Tim B. Dyrby, Takeshi Asahi, Marcelo Galvez, Gonzalo Rojas

Dataset-Independent Reconstruction of High Angular Resolution Diffusion Sampling Schemes by Generalized Q- Space Imaging...... 4125 Fang-Cheng Yeh, Van Jay Wedeen, Wen-Yih Isaac Tseng

Dual Q-Ball Imaging Reveals Intravoxel Orientation Distribution Functions for Laminar Structures in the Heart ...... 4126 Hans Dierckx, Alan P. Benson, Stephen H. Gilbert, Mike E. Ries, Arun V. Holden, Henri Verschelde, Olivier Bernus

The Effect of the Acquisition Parameters for High Angular Resolution Diffusion Imaging...... 4127 Vesna Prckovska, Alard F. Roebroeck, Pim W.L.P.M. Pullens, Anna Vilanova, Bart M. ter Haar Romeny

Application of Automated Fiber Tract Identification and Restriction Spectrum Imaging to Study Microstructural Changes in White Matter Tracts Associated with Temporal LobeEpilepsy...... 4128 Donald Joseph Hagler, Nathan S. White, Christopher J. Pung, Carrie R. McDonald, Eric Halgren,Anders M. Dale

Mixture Model for Estimating Fiber ODF and Multi-Directional Tractography ...... 4129 Yogesh Rathi, James Malcolm, Sylvain Bouix, Gordon Kindlmann, Carl-Fredrik Westin, Marek Kubicki, Martha E. Shenton

Evaluation of Angular Uncertainties of Q-Space Diffusion MRI Under Finite Gradient Pulse Widths : A Phantom Study ...... 4130 Chun-Hung Yeh, Jacques-Donald Tournier, Kuan-Hung Cho, Cyril Poupon, Ching-Po Lin

Effects of Coregistration for the Reconstruction of High Angular Resolution Diffusion Imaging ...... 4131 Yi-Ping Chao, Kun-Hsien Chou, Kuan-Hung Cho, Chun-Hung Yeh, Jyh-Horng Chen, Ching-Po Lin

A Web-Based Probabilistic Tractography Database...... 4132 Chris James Rose, David Ellard, David Morris, Hamied Haroon, Karl Embleton, Nikos K. Logothetis, Matthew A. Lambon Ralph, Geoffrey J. Parker

Probabilistic Tractography Driven White Matter Width Measurement ...... 4133 Hojjatollah Azadbakht, David Mark Morris, Hamied Ahmed Haroon, Karl V. Embleton, Brandon J. Whitcher, Julie Snowden, Geoff J. Parker

Regional Microstructural Differences of the Corpus Callosum Using Cytoarchitectural Parcellation and DT-MRI...... 4134 Yi-Ping Chao, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Jyh-Horng Chen, Ching-Po Lin

Quantitative Tractography Metrics of White Matter Integrity in Diffusion-Tensor MRI Using Diffusivity Scalars ...... 4135 Eni Halilaj, Cagatay Demiralp, Stephen Correia, David H. Laidlaw

Optimization of Diffusion Sequences Using Bootstrap Algorithms...... 4136 Carolin Reischauer, Robert Stefan Vorburger, Philipp Staempfli, Peter Boesiger

An Evaluation of Contrast-To-Noise Ratios for Diffusion Anisotropy Metrics in the Presence of Multiple Fibres ...... 4137 Marta Morgado Correia, Virginia FJ Newcombe, Thomas Adrian Carpenter, Guy B. Williams

Making the Robust Tensor Estimation Approach: "RESTORE" More Robust ...... 4138 Lin-Ching Chang, Lindsay Walker, Carlo Pierpaoli

Investigation of DTI Bootstrap Reproducibility in the Human Brain ...... 4139 Robert Stefan Vorburger, Carolin Reischauer, Katerina Dikaiou, Philipp Staempfli, Peter Boesiger

Probabilistic Corticocortical Connectivity Maps of Human Brain Based on DTI Tractography and Cortical Parcellation...... 4140 Hao Huang, Jerry L. Prince, Aaron Carass, Bennett Landman, Peter C.M. van Zijl, Susumu Mori

Sex Differences in the Human Corpus Callosum Microstructure: T2 Myelin-Water Imaging Versus Diffusion Tensor Imaging...... 4141 Logi Vidarsson, Fang Liu, Andrea Kassner

Summary Statistics for Diffusion Tensor Imaging Brain Templates: Mean Vs. Median Tensors...... 4142 Huiling Peng, Shengwei Zhang, Robert John Dawe, Anton Orlichenko, Gady Agam, Konstantinos Arfanakis

Mapping Crossing Fibres of the Human Brain with Spherical Deconvolution: Towards an Atlas for Clinico- Anatomical Correlation Studies...... 4143 Flavio Dell'Acqua, Joan Coward, Andy Simmons, Declan Murphy, Steve Williams, Marco Catani

Implications of Physiological Motion on DTI Values in the Cervical Spinal Cord...... 4144 Celina Nahanni, Patrick W. Stroman

Effect of Reference Template Selection in Diffusion Tensor Based Voxel-Wise Analysis ...... 4145 Hsuan-Hui Wang, Kun-Hsien Chou, Pei-Chin Chen, I-Yun Chen, Ching-Po Lin

Population Based Probabilistic Neural Tracts Atlas of Human Brain...... 4146 Chun-Yi Lo, Yi-Ping Chao, Ke-Hsin Chen, Kun-Hsien Chou, Ching-Po Lin,

Functional MRI Results Guided ROI Selection & Probability Map Making on DTI Study: The White Matter Route for Orthography-To-Phonology Transformation in Chinese...... 4147 Ke-Hsin Chen, Yi-Ping Chao, Chun-Yi Lo, Ching-Po Lin

A New Quality Measure for Gradient Encoding Schemes...... 4148 Sarah C. Mang, Daniel Gembris, Wolfgang Grodd, Uwe Klose

A Tensor Approach for Double Wave Vector Experiments on Microscopic Anisotropy ...... 4149 Marco Lawrenz, Martin A. Koch, Jürgen Finsterbusch

Optimized Measurement of Anomalous Diffusion...... 4150 Justin P. Haldar, Qing Gao, Xiaohong Joe Zhou, Zhi-Pei Liang

On the Problem of Gradient Calibration in DWI...... 4151 Oleg P. Posnansky, Yuliya Kupriyanova, N. Jon Shah,

Generalized MAGSTE with Improved Diffusion-Weighting Efficiency...... 4152 Jürgen Finsterbusch

Double-Wave-Vector Diffusion-Weighting Experiments with Multiple Concatenations ...... 4153 Jürgen Finsterbusch

Optimal Strategy for B-Values Selection for Lung Morphometry with Hyperpolarized 3He Diffusion MRI ...... 4154 Alexander L. Sukstanskii, Jim D. Quirk, Mark S. Conradi, Dmitriy A. Yablonskiy

A New and Versatile Gradient Encoding Scheme for DTI: A Direct Comparison with the Jones Scheme...... 4155 Rüdiger Stirnberg, Tony Stöcker, N. Jon Shah

Regularisation of Fractional Anisotropy Using Neighbourhood Information ...... 4156 Marta Morgado Correia, Virgina FJ Newcombe, Thomas Adrian Carpenter, Guy B. Williams

Effective Reduction of CSF Partial Volume Effect in DTI by Acquiring Additional DWIs with Smaller B-Value...... 4157 Edward S. Hui, Joseph A. Helpern, Ed X. Wu

Effects of Voxel Size, B-Factor and Averaging on the Test-Retest Reproducibility of DTI-Derived Fractional Anisotropy at 4T...... 4158 Nico Dario Papinutto, Jorge Jovicich

Effect of Voxel Size on DTI Fractional Anisotropy ...... 4159 Ramtilak Gattu, Z Latif, Zhifeng Kou, Ewart M. Haacke, Randall R. Benson

Metric Selection and Variability Maps for Diffusion Tensor Data...... 4160 Ofer Pasternak, Nir Sochen, Peter Joel Basser

Quantitative Tissue Structure Characterization with Temporal Diffusion Spectroscopy ...... 4161 Junzhong Xu, Mark D. Does, Ke Li, Daniel F. Gochberg, John C. Gore

Diffusion in Brain Tissue Modelled as Random Walks Under Confinements and Trapping Constraints ...... 4162 Farida Grinberg, A. M. Oros-Peusquens, Yuliya Kupriyanova, Oleg Posnansky, N. Jon Shah

Estimation of Cell Membrane Permeability and Intracellular Diffusion Coefficient of the Gray Matter in the Normal Human Brain ...... 4163 Toshikazu Imae, Hiroyuki Shinohara, Masaki Sekino, Hiroyuki Ohsaki, Shoogo Ueno, Kazuo Mima, Kuni Ohtomo

Procrustes Analysis of Diffusion Tensor Data...... 4164 Diwei Zhou, Ian L. Dryden, Alexey Koloydenko, Li Bai

A Voxel-Based Analysis of SNR Effect on Diffusion Tensor Imaging...... 4165 Lian Xue, Liangsuo Ma, Khader M. Hasan

Voxel Based Topometry: Collapse Onto a Sphere or an Ellipsoid? ...... 4166 Oleg P. Posnansky, N. Jon Shah

Improved Results of Voxel-Based DTI Analyses by Using Non-Rigid Coregistration and a Population-Based DTI Atlas ...... 4167 Caroline A. Sage, Wim Van Hecke, Ronald Peeters, Jan Sijbers, Wim Robberecht, Judith Verhoeven, Sabine Deprez, Paul Parizel, Guy Marchal, Alexander Leemans, Stefan Sunaert

Supertoroid-Based Characterization of Cardiac Diffusion Tensor Fields...... 4168 Choukri Mekkaoui, Marcel P. Jackowski, Albert J. Sinusas

Analytic Description of MR Diffusion Indices in Ex-Vivo Human Hypertrophic Cardiomyopathy...... 4169 Eric Stephant, Carole Frindel, Marc Robini, Laurent Fanton, Magalie Viallon, Pierre Croisille

Measuring Axial and Radial Diffusivities in the Brain...... 4170 Claudia A.M. Wheeler-Kingshott, Daniel C. Alexander, Torben Schneider, Mara Cercignani

The Relationship Between "Axial" and "Radial" Diffusivities and the Eigenvectors of the Diffusion Tensor in the Brain...... 4171 Claudia A.M. Wheeler-Kingshott, Daniel C. Alexander, Mara Cercignani

White Matter Injury in Germinal Matrix Hemorrhage in Rabbit Pup Model Detected by DTI...... 4172 Halima Chahboune, Caroline Chua, Praveen Ballabh, Fahmeed Hyder

DTI Detects FA Changes in the Internal Capsule and Thalamus in Rat After Traumatic Brain Injury - Comparison with Histology ...... 4173 Teemu P. Laitinen, Alejandra Sierra Lopez, Tamuna Bolkvadze, Asla Pitkänen, Olli H. Gröhn

Fractional Anisotropy Correlates with Social Behavior Symptoms in a Mouse Model Relevant to Autism...... 4174 Sungheon Kim, Steve Pickup, Andrew H. Fairless, Ranjit Ittyerah, Holly C. Dow, Ted Abel, Edward S. Brodkin, Harish Poptani

Characterization of Cortex and White Matter Injury in a Mild Hypoxic-Ischemic Neonatal Rat Model by Diffusion Tensor MR Imaging ...... 4175 Silun Wang, Ed. X. Wu, Ho-Fai Lau, Pek-Lan Khong

Design and Setup of Dynamic Contrast Enhanced Experiments for Longitudinal Preclinical Studies of Tumor Response to Anti-Angiogenic Therapy...... 4176 Jan Sedlacik, Regan Williams, Melissa Johnson, Chris Calabrese, Andrew M. Davidoff, Claudia M. Hillenbrand

Evaluation of Interleukin-2 Neurovascular Toxicity Using DCE-MRI...... 4177 Yetty Yennawati Irwan, H. Michael Gach, Yi Feng, Gopalkrishna Veni, Wolfram E. Samlowski

Functional Bolus-Tracking Arterial Spin Labeling; a New Approach to Quantitative fMRI...... 4178 Michael Edward Kelly, Christoph Wolfgang Blau, Oliviero Leopoldo Gobbo, Karen Mary Griffin, James Francis Xavier Jones, Christian Mattheis Kerskens

Fast Bolus-Tracking fMRI in Medetomidine-Sedated Rats Using Intravascular Tracer: Towards Quantitative fMRI...... 4179 Christoph Wolfgang Blau, Karen Mary Griffin, Oliviero Leopoldo Gobbo, James Francis Xavier Jones,Christian Matthias Kerskens

High-Field Diffusion Tensor Imaging on a Mouse Model of Leukoencephalopathy ...... 4180 Yohan van de Looij, Géraldine Favrais, Pierre Gressens, Petra S. Hüppi, Rolf Gruetter, Stéphane V. Sizonenko

Explanation of High Fractional Anisotropy Value in the Wall and Cavity of the Brain Abscess Differs as Evident by Histology and Immunohistochemistry ...... 4181 Rakesh K. Gupta, Sona Saksena, Nuzhat Husain, Mazhar Husain, Savita Srivastava, Mahesh Ramola,Rishi Awasthi, Kashi N. Prasad, Ram K.S. Rathore

Time-Dependent Diffusion MRI in the Neocortex of Aquaporin-4 Deficient and Normal Mice in the Resting State at 7T ...... 4182 Tina Pavlin, Christian Brekken, Pål Erik Goa, Anna Thoren, Ole Petter Ottersen, Erlend A. Nagelhus, Asta Håberg

DTI Abnormalities in Anterior Corpus Callosum of Rats with Spike-Wave Epilepsy ...... 4183 Halima Chahboune, Asht Mishra, Matthew Desalvo, Lawrence Staib, Magor Lorincz, Vincenzo Crunelli, Fahmeed Hyder, Hal Blumenfeld

Hemodynamics of the Hippocampus and Perilesional Cortex in the Acute and Sub- Acute Phases After Traumatic Brain Injury in Rats ...... 4184 Nick Mark Edward Alexander Hayward, Riikka Immonen, Asla Pitkänen, Olli Gröhn

Age-Dependent Impairment of the Cerebrovascular Reactivity to CO2 in Spontaneously Hypertensive Rats: An ASL Study ...... 4185 Renata F. Leoni, Fernando F. Paiva, Draulio B. de Araujo, Afonso C. Silva

A DTI Study of Diffusion Anisotropy on CRMP-1 Knockout Mice ...... 4186 Kuan-Hung Cho, Bing-Hsuan Lei, Jyh-Horng Chen

Absolute Cerebral Volume Quantification by Vascular Space Occupancy Technique on Rat Model with Optimized Inversion Time ...... 4187 Chien-Chung Chen, Yi-Chun Wu, Chou-Ming Cheng, Tzu-Chen Yeh, Fu-Nien Wang

Errors in DCE MRI Measurements Due to Errors in Gd Concentration Estimates...... 4188 Vishal Patil, Glyn Johnson

3D Sequences Used for DCE-MRI Can Exhibit Initial Instabilities That Will Affect T1 Quantification...... 4189 Michael Germuska, James A. d'Arcy, Keiko Miyazaki, Matthew R. Orton, Geoffrey S. Payne, Martin O. Leach, David J. Collins

Analytical Equation of State for Rapid and Direct Quantification of Longitudinal Relaxation Time (T1) in Look- Locker Sequences ...... 4190 Hassan Bagher-Ebadian, Ramesh Paudyal, James Russel Ewing

Dynamic Contrast Enhanced MRI Parameters Independent of Baseline T1 Values ...... 4191 Junyu Guo, Wilburn E. Reddick

MRI Surrogates of Blood Flow Estimates in the Malignant Prostate Gland ...... 4192 Roberto Alonzi, Peter Hoskin, N Jane Taylor, J James Stirling, James A. d'Arcy, David J. Collins, Anwar R. Padhani

Volume 8

Pre-Bolus Quantification of Arterial Input Functions by Non-Steady-State Analysis of Gradient-Echo Dynamic Imaging ...... 4193 Matthew R. Orton, Michael Germuska, Keiko Miyazaki, Dow-Mu Koh, David J. Collins, Martin O. Leach

Onset Estimation for Dual Input DCE-MRI Liver Data : Information Criteria Used to Determine Statistical Optimality of Global or Pixel-Wise Onset Estimation ...... 4194 Matthew R. Orton, Keiko Miyazaki, Dow-Mu Koh, David J. Collins, David Atkinson, David J. Hawkes, Martin O. Leach

Novel Method of Portal Delay and Dispersion Estimation for Dual-Input Kinetic Modelling of DCE-MRI Liver Data ...... 4195 Matthew R. Orton, Keiko Miyazaki, Dow-Mu Koh, David J. Collins, David Atkinson, David J. Hawkes, Martin O. Leach

Quantitative Mapping of Cerebral Blood Flow Change Using Phase Information of SWI...... 4196 Yuri Zaitsu, Kohsuke Kudo, Rie Yazu, Kinya Ishizaka, Noriyuki Fujima, Khin Khin Tha, Satoshi Terae, Makoto Sasaki, Hiroki Shirato

Bolus Perfusion-Weighted Imaging Measurement of Quantitative Cerebral Blood Flow Can Be Improved Using an Arterial Spin Label Derived Scaling Factor: a Comparative Xenon CT Study...... 4197 Greg Zaharchuk, Matus Straka, Ajit Shankaranarayan, David C. Alsop, Michael E. Marks, Michael E. Moseley, Roland Bammer

SCALE PWI: A Pulse Sequence for Quantitative Cerebral Perfusion Imaging...... 4198 Jessy J. Mouannes, Saurabh Shah, Wanyong Shin, Octavia Biris, Timothy J. Carroll

Reference-Based CBF Index of Maximum Upslope Without Using Arterial Input Function in Dynamic Susceptibility Contrast MRI: Comparison with Deconvolution Method...... 4199 Tokunori Kimura, Hiroshi Kusahara

Prediction of Hemorrhagic Transformation in Acute Ischemic Stroke: A Comparison of DSC Surrogate Measures of Permeability...... 4200 Rebecca E. Thornhill, Shuo Chen, Wael Rammo, David J. Mikulis, Andrea Kassner

Unique Thalamic Perfusion Abnormalities in Painful But Not Painless Diabetic Peripheral Neuropathy ...... 4201 Dinesh Selvarajah, Celia Emery, Rajiv Gandhi, Paul Griffiths, Solomon Tesfaye, Iain Wilkinson

Quantification of Brain Perfusion in Patients with Internal Carotid Stenosis and Perfusion Change After Carotid Stenting Based on Dynamic Susceptibility Contrast-Enhanced MRI ...... 4202 Mao-Yuan Su, H-L Kao, Y-W Wu, H-Y Yu, W-C Chu, W-Y Isaac Tseng

Estimation of Contrast Agent Extravasation from the Tissue Residue Function: Application to Tumor Perfusion Imaging ...... 4203 Atle Bjornerud, Kyrre E. Emblem

Assessment of Blood-Brain Water Transfer by Arterial Spin Labeling Based T2 Measurements...... 4204 Johannes Gregori, Matthias Günther, Norbert Schuff

Measuring Blood T1 in the Jugular Vein: Juggling Size, Speed and Precision...... 4205 Qin Qin, Peter CM. van Zijl

Adaptive Sequential Design for Optimal Scheduling of Continuous ASL Data Acquisition...... 4206 Jingyi Xie, Peter Jezzard, Daniel Gallichan, Roger Gunn, Stuart Clare

The Influence of Design and Position of the Labeling Coil on the Efficiency in CASL Experiments at 7 T – a Computer Simulation...... 4207 Robert Trampel, Mikhail Kozlov, Thies Jochimsen, Enrico Reimer, Toralf Mildner, Robert Turner

Detection of CBF Changes Due to Activation Over One Month Using ASL Functional MRI ...... 4208 Ajna Borogovac, Joy Hirsch, Iris Asllani

Performance of Pseudo-Continuous Arterial Spin Labeling in the Estimation of Fractional Changes in CBF with Activation: Comparison with QUIPSS II ...... 4209 Wen-Ming Luh, Eric C. Wong, Peter A. Bandettini

Arterial Transit Time Effects in Pulsed Arterial Spin Labeling CBF Mapping: Insight from a PET and MR Study of Normal Human Subjects ...... 4210 Maolin Qiu, Jinghua Wang, Jagriti Arora, Yuenan Wang, Heyonjin Kim, Nallakkandi Rajeevan, Beata Planeta-Wilson, David Weinzimmer, Richard E. Carson, Robert Todd Constable

Effects of 24hr of Total Sleep Deprivation on Resting CBF Differs in High-Vulnerable and Low-Vulnerable Adults ...... 4211 Hengyi Rao, Julian Lim, John A. Detre, Wenchau Wu, David F. Dinges

Is Cardiac Gating Necessary in ASL? a Computational and Experimental Study of Flow Dispersion and Cardiac Pulsations...... 4212 Samira M. Kazan, Michael A. Chappell, Stephen J. Payne

Perfusion and Flow Measurement in Human Brain by Pseudo Random Amplitude Modulation (PRAM) in 3T MRI ...... 4213 Mohammad Reza Taei-Tehrani, Truman R. Brown

Improved Pseudo-Continuous Arterial Spin Labeling (ASL) for Cerebral Blood Flow Mapping ...... 4214 Marzieh Nezamzadeh, Gerald B. Matson, Karl Young, Michael W. Weiner, Norbert Schuff

Quantitative Dynamic MR Angiography Using ASL Based TrueFISP ...... 4215 Lirong Yan, Yan Zhuo, Jiongjiong Wang

Baseline CBF Correlation with Individual Alpha Peak Frequency...... 4216 Kay Jann, Thomas Koenig, Chris Boesch, Thomas Dierks, Andrea Federspiel

Investigating Transcranial Magnetic Stimulation (TMS) Effects Using Pulsed Arterial Spin Labeling (PASL) ...... 4217 Andrea Federspiel, Ariane Orosz, Kay Jann, Matthias Grieder, Miranka Wirth, Roland Wiest, Thomas Dierks

Cerebral Perfusion in Craniosynostotic Rabbits Using ASL_MRI ...... 4218 Lesley M. Foley, Wendy Fellows-Mayle, T Kevin Hitchens, Joseph E. Losee, M I. Siegel, M P. Mooney, Chien Ho,

Colloid Based Resuscitation Following Asphyxial Cardiac Arrest: ASL_MRI Assessment of Regional Cerebral Blood Flow...... 4219 Lesley M. Foley, Mioara D. Manole, T Kevin Hitchens, Patrick M. Kochanek, Robert W. Hickey, Henry L. Alexander, Hulya Bayir, Chien Ho, Robert S. Clark

Characterization of Vascular Territory Changes Following Carotid Artery Compression Using Arterial Spin Labeling MRI...... 4220 Akash Pravin Kansagra, Eric Che Wong

Can Arterial Spin Labeling Be Used to Identify Perfusion Distribution Differences Using Group Analysis?...... 4221 Dennis Armand Kies, Julien R. Milles, Wouter M. Teeuwisse, Johan R.C. Reiber, Andrew Webb, Mark A. Van Buchem, Matthias J.P. Van Osch,

Estimation of Pure Gray Matter Perfusion Using Pseudo-Continuous Arterial Spin Labeling and Partial Volume Correction...... 4222 Wen-Ming Luh, Peter A. Bandettini

Pseudo-Continuous Artery-Selective Spin Labeling (Pseudo-CASSL) ...... 4223 Michael Helle, Matthias van Osch, David G. Norris, Susanne Rüfer, Karsten Alfke, Olav Jansen

Cerebral Blood Flow and Transit Time Measured by Quantitative Arterial Spin Labeling: Comparison with 15O- PET...... 4224 Hironori Kamano, Takashi Yoshiura, Akio Hiwatashi, Koji Yamashita, Eiki Nagao, Yukihisa Takayama, Tomoyuki Noguchi, Koichiro Abe, Koichiro Kaneko, Ivan Zimine, Tomoyuki Okuaki, Hiroshi Honda

Arterial Spin Label CBF Maps Can Show Abnormalities in Clinical Patients with Normal Bolus Perfusion- Weighted Imaging: Identification of the "Watershed Sign"...... 4225 Greg Zaharchuk, Ajit Shankaranarayan, Roland Bammer, Matus Straka, David C. Alsop, Nancy J. Fischbein, Scott W. Atlas, Michael E. Moseley

Assessment of Cerebral Perfusion MRI Using Arterial Spin Labeling and Dynamic Susceptibility Contrast in Individuals with Carotid Artery Disease ...... 4226 Bradley J. MacIntosh, Ediri Sideso, Manus J. Donahue, Atle Bjørnerud, Matthias Günther, Ashok Handa, James Kennedy, Peter Jezzard

Cerebral Blood Flow and Arterial Transit Time Measurements in Patients with Chronic Occlusive Cerebrovascular Disease Using 3D Spiral SE Arterial Spin Labeling on 3T-MR: Correlative Study with O15 Labeled H2O PET Examination...... 4227 Hirohiko Kimura, Hidehiko Okazawa, Tsuyoshi Matsuda, Yoshikazu Arai, Asit Shankaranarayanan,David Alsop

LL-FAIR: Implementation and Application at 7T ...... 4228 Susan T. Francis, Roman Wesolowski, Emma L. Hall, Penny A. Gowland

Accurate Gray Matter CBF Mapping in Whole Brain IR 3D PULSAR Imaging Through Flip Angle Modulation...... 4229 Neville Dali Gai, Sardha Lalith Talagala, John Butman

What Is the Detectability of Arterial Transit Times in Pulsed Arterial Spin Labeling (PASL): A Simulation and Empirical Study ...... 4230 Bradley J. MacIntosh, Nicola Filippini, Manus J. Donahue, Michael A. Chappell, Clare E. Mackay, Peter Jezzard

CSF-Suppression Improves Signal Stability of ASL Time Series...... 4231 Yufen Chen, David Minkoff, Jiongjiong Wang, John A. Detre

Automated Segmentation of Multiple Vascular Territories from Vessel Encoded Pseudo-Continuous Arterial Spin Labeling MRI Data...... 4232 Akash Pravin Kansagra, Eric Che Wong

Utility of Shared Rotating Control Acquisition for Territorial ASL...... 4233 Ivan Zimine, Takashi Yoshiura, Akio Hiwatashi, Tomoyuki Noguchi, Marc Van Cauteren

Theoretical Investigation and Optimization of the Labeling Process in Continuous Artery-Selective Spin Labeling (CASSL)...... 4234 Michael Helle, David G. Norris, Susanne Rüfer, Karsten Alfke, Olav Jansen

2D RF Versus Slice Selective RF Tagging Pulses in Brain ASL...... 4235 Simon Konstandin, Patrick Michael Heiler, Lothar Rudi Schad

Fast Measurement of Arteriovenous Oxygenation Differences Using Blood T2 in the Jugular Vein and Carotid Artery at 3T...... 4236 Qin Qin, Peter C.M. van Zijl

Investigation Into the Benefits of 3D-EPI for High-Resolution fMRI at 7T...... 4237 Benedikt Andreas Poser, Peter J. Koopmans, Lawrence L. Wald, Markus Barth

Frequency-Dependent Cerebral Blood Flow-Volume Coupling in Activated Human Visual Cortex ...... 4238 Ai-Ling Lin, Peter T. Fox

Feasibility of QUantitative Imaging of EXtraction of Oxygen and Tissue Consumption (QUIXOTIC) to Assess Functional Changes in Venous Oxygen Saturation During Visual Stimulus ...... 4239 Divya S. Bolar, A Gregory Sorensen, Bruce R. Rosen, Elfar Adalsteinsson

Mapping the Cerebral Blood Volume Response to Cocaine with Pharmacological MRI in Mice at 7 T...... 4240 Adriana Teodora Perles-Barbacaru, Daniel Procissi, Andrey Valentinovich Demyanenko, Russell E. Jacobs

T1 Sensitive Images with the Aid of New Blood-Pool Contrast Agent in Mapping Cortical Centers in Neurosurgical Patients ...... 4241 Agata Majos, Tomasz Wolak, Piotr Bogorodzki, Krzysztof Tybor, Mariusz Heleniak, Ludomir Stefañczyk

Stability of Alternating BSSFP Signal in the Presence of Driving Perturbations...... 4242 Giedrius T. Buracas, Youngkyoo Jung, Eric C. Wong, Richard B. Buxton, Thomas T. Liu

Motion-Compensated Interleaved Spiral Acquisition for fMRI ...... 4243 Heiko Schmiedeskamp, Murat Aksoy, Gary H. Glover, Roland Bammer

Best Practice EEG-MRI: The Utility of Retrospective Synchronization and PCA for the Removal of Gradient Artefacts...... 4244 Hendrik Mandelkow, Daniel Brandeis, Peter Boesiger

Characterising Gradient Artefacts in Simultaneous EEG/fMRI Through Physical Modelling...... 4245 Winston X. Yan, Karen J. Mullinger, Matthew J. Brookes, Richard W. Bowtell

Silent High Resolution Echo-Planar Imaging for Auditory fMRI...... 4246 Jascha Zapp, Sebastian Schmitter, Lothar R. Schad

Silent Sparse Sampling for Auditory fMRI...... 4247 Todd Parrish, Vibhas Deshpande, Yu Fen Chen

A Novel T2 GRASE Single-Shot 3D Sequence for BOLD Imaging ...... 4248 David A. Feinberg, Sudhir Ramanna

First Demonstration of SS-PARSE in Detecting the BOLD Effect in Humans...... 4249 Edward Walsh, Donald Twieg, Michael Worden, Stanley Reeves, Jerome Sanes,

MR-Encephalography: Fast Volumetric Imaging of Brain Physiology Using Rosette Trajectories ...... 4250 Benjamin Zahneisen, Thimo Grotz, Juergen Hennig

Pushing the Limits: Ultrafast 2D Accelerated High Resolution Whole-Head Volumetric Functional Imaging at 7 Tesla ...... 4251 Tram Nguyen, Steen Moeller, Ute Goerke, Essa Yacoub, Kamil Ugurbil

Comparison Between End-Tidal CO2 and Tidal Volume Changes Calculated from the Respiratory Motion Tracing Used for Correction of Respiratory Fluctuations in a Functional MRI Experiment with Normal Breathing and Hyperventilation ...... 4252 Keith Michael Vogt, James W. Ibinson, Robert H. Small, Petra Schmalbrock

Activity-Based Seed Regions for Resting-State fMRI Analysis Are Susceptible to Large Vessels...... 4253 Ali Mohammad Golestani, Bradley Goodyear

Stockwell Coherence Measures Resting-State Connectivity with Low Between-Session Variability ...... 4254 Ali Mohammad Golestani, Bradley Goodyear

Functional Network Connectivity with Temporal Derivatives of sICA Time-Courses in Schizophrenia Patients Vs Healthy Controls...... 4255 Unal Sakoglu, Vince D. Calhoun

Dynamic Windowing Reveals Task-Modulation of Functional Connectivity in Schizophrenia Patients Vs Healthy Controls ...... 4256 Unal Sakoglu, Vince D. Calhoun

Minimum Resolvable Latency Difference of BOLD Responses at 7T Using Autoregressive Modeling...... 4257 Santosh Bahadur Katwal, James Christopher Gatenby, John C. Gore, Baxter P. Rogers

New Tools for Analysis of MRI Datasets ...... 4258 Robert W. Cox, Ziad S. Saad, Gang Chen, Daniel R. Glen, Richard C. Reynolds

Slice-Timing Correction Affects Functional MRI Noise, Model Fit, Activation Maps, and Physiologic Noise Correction...... 4259 Keith Michael Vogt, James W. Ibinson, Robert H. Small, Petra Schmalbrock

Standardized and Automatic Framework for Functional Connectivity Analysis: Functional Correlation Matrix and Sorted Index Curve...... 4260 Nan-kuei Chen, Ying-hui Chou, Lawrence P. Panych, David J. Madden, Allen W. Song

A Novel Activation Threshold Selection for fMRI Data Using Order Statistics ...... 4261 Rajesh Ranjan Nandy

Function Lateralization Through Measuring Coherence Laterality...... 4262 Ze Wang, John Pluta, Dawn Mechanic-Hamilton, Simon Glynn, John A. Detre

A Technique to Detect Outliers Automatically in Multi-Site fMRI Data ...... 4263 Andrew Mario Michael, Stefi A. Baum, Vince D. Calhoun

Wavelet Shrinkage Versus Gaussian Spatial Filtering of Functional MRI Data...... 4264 Ruxandra Mutihac, Radu Mutihac

Using Real-Time fMRI to Control a Dynamical System...... 4265 Anders Eklund, Henrik Ohlsson, Mats Andersson, Joakim Rydell, Anders Ynnerman, Hans Knutsson

Multivariate Analysis of the Default-Mode Network in Healthy Subjects at Rest...... 4266 Paola Valsasina, Maria Assunta Rocca, Paolo Misci, Elisabetta Pagani, Andrea Falini, Massimo Filippi

Watching the Brain Going to Sleep: A Dynamic ICA Approach...... 4267 Michael Czisch, Renate Wehrle, Victor I. Spoormaker, David Höhn, Henning Peters, Florian Holsboer, Philipp G. Sämann

The Intrinsic Activity of the Brain Can Be Modulated by Cognitive Load...... 4268 Tommaso Gili, Federico Giove, Vittorio Iacovella, Emiliano Macaluso, Bruno Maraviglia fMRI Group Analysis with Spatial Bayesian Variable Selection...... 4269 Rajesh Ranjan Nandy, Brad Mcevoy

Fusion of Structural-Functional Brain Images Reveals Differences in Schizophrenia in a Multi Site Study...... 4270 Andrew Mario Michael, Stefi A. Baum, Vince P. Clark, Rex Jung, Kelvin O. Lim, Tonya White, Beng C. Ho, Randy L. Gollub, Vince D. Calhoun

Brain Areas Attuned to Changes in the Prosodic Focus of Repeated Spoken Sentences – an fMRI Study...... 4271 Michael Inspector, David Manor, Tammar Kushnir, Yael Gogol, Noam Amir, Avi Karni

Mapping Human Somatosensory Cortex with fMRI at 7 T: Travelling Wave and Event-Related Paradigms ...... 4272 Rosa Maria Sanchez Panchuelo, Sue Francis, Denis Schluppeck, Richard Bowtell

A Magnetic Resonance Compatible Stepper (MARCOS) for fMRI Investigation of Gait ...... 4273 Christoph Hollnagel, Ningbo Yu, Armin Blickenstorfer, Peter Wolf, Volker Dietz, Spyros Kollias,Robert Riener

Caloric and Non-Caloric Versions of a Soft Drink Differentially Affect Taste Activation Before Consumption ...... 4274 Paul Smeets, Pascalle Weijzen, Cees de Graaf, Max Viergever

Neural Correlates of Altruistic and Deontological Guilt: An fMRI Investigation in Healthy Individuals ...... 4275 Barbara Basile, Marco Bozzali, Emiliano Macaluso, Francesco Mancini

Accompanying Event-Related Decrease of Alpha Band EEG and Sustained Negative BOLD Response at Ipsilateral Primary Sensorimotor Area ...... 4276 Han Yuan, Rebecca Szarkowski, Cristina Rios, James Ashe, Bin He

High Resolution fcMRI: Degrees of Correlation Within the Rat Brain Finger Representation...... 4277 James S. Hyde, Christopher P. Pawela, Bhart B. Biswal, Rupeng Li, Younghoon R. Cho

Time Invariant BOLD Impulse Response Functions for Brief- And Long-Lasting Stimuli...... 4278 Peter Herman, Basavaraju G. Sanganahalli, Hal Blumenfeld, Fahmeed Hyder

Neurocognitive Mapping of Spatial Working Memory in Hyperthyroidism – an fMRI Study ...... 4279 Manisha Bhattacharya, Subash Khushu, Shilpi Modi, Tarun Sekhri, Rajendra Prasad Tripathi

Paying Attention When It Counts: The Effect of Motivation on fMRI Activity During Attentional Control...... 4280 Tracy L. Luks, Ashley Kopec, Corby L. Dale, Gregory V. Simpson, Anthony Kaveh

Calibrating the BOLD Signal Revisited – Calculation of Oxygen Metabolism for Gradient- And Spin-Echo Sequence Up to 16.4T...... 4281 Kamil Uludag, Anne-Catherin Zappe, Jozien Goense, Nikos K. Logothetis

Temporal Changes of BOLD fMRI Activation in a Block Design ...... 4282 Arthur Peter Wunderlich, Gregor Stuber, Wolfgang Freund

The Effect of Hypercapnia on Resting State fMRI...... 4283 Jinsoo Uh, Feng Xu, Uma Yezhuvath, Yamei Cheng, Hong Gu, Yihong Yang, Hanzhang Lu

Reward Sensitivity and Positive Affect Influence Brain Activation to Food Pictures of Different Caloric Value...... 4284 Christina Gabriele Prechtl de Hernandez, John D. Beaver, Charlotte Croese, Kinan Muhammed, Gabriel Bell, Giuliana Durighel, Emer Hughes, Adam D. Waldman, Gary Frost, Jimmy D. Bell, Anthony P. Goldstone

Attentional Modulation of Thermal Sensory Responses in the Human Spinal Cord...... 4285 Patrick W. Stroman, Brian Coe, Chase R. Figley, Jordan Leitch, Doug P. Munoz

Effects of High and Low Spatial Filtering and Spatial Location of Fearful Faces on Amygdala and Fusiform Gyrus Activity...... 4286 Carmen Morawetz, Juergen Baudewig, Stefan Treue, Peter Dechent

Using fMRI to Demonstrate Tolerance to the Rewarding and Anxiolytic Effects of Alcohol in Heavy Drinkers ...... 4287 Jodi Gilman, Vijay Ramchandani, Tess Crouss, Daniel Hommer

Activation of Inferior Frontal Gyrus During Response Inhibition: Effects of Citalopram and Acute Tryptophan Depletion Depend on Neocortical 5-HT2A Receptor Levels...... 4288 Julian Macoveanu, Bettina Hornboll, Rebecca Elliott, Hartwig Siebner, David Erritzoe, Olaf B. Paulson, Gitte M. Knudsen, James B. Rowe

A High-Field Human Brain Interface Using a Modular Virtual Environment System for Real Time fMRI ...... 4289 Charles Mueller, Ramona Grzeschik, Maurice Hollmann, Sebastian Baecke, Ralf Lützkendorf, Johannes Bernarding

Separate Neural Systems for Evaluating Risks and Reward in Decision Making ...... 4290 Julian Macoveanu, Jon Wegener, Arnold Skimminge, Bettina Hornboll, Rebecca Elliott, Hartwig Siebner, Olaf B. Paulson, James B. Rowe

A Functional Dissociation Between the Left and the Right Cerebellum During Sensorimotor Synchronization: A BOLD fMRI Study ...... 4291 Janine D. Bijsterbosch, Kwang-Hyuk Lee, Daniel T. Tsoi, Peter W R Woodruff, Iain D. Wilkinson

Simultaneous Dual-fMRI, Sparse Temporal Scanning of Human Duetters at 1.5 and 3 Tesla...... 4292 Lawrence M. Parsons, Evangelos T. Himonides, Nyssa Craig, Monica Vakil, Robert S. Turner, Iain D. Wilkinson

Impact of Noise-Modelling Methods on Test-Retest Reliability of a Covert Verbal Fluency fMRI Task Across 2 Sites ...... 4293 Jonathan O'Muircheartaigh, Christian Vollmar, Gareth Barker, Mark Symms, Veena Kumari, Pam Thompson, John Duncan, Matthias Koepp, Mark Richardson

Rapid Digit Mapping in the Human Brain at 3T...... 4294 Jolinda Smith, Sergei Bogdanov, Scott Frey

The Cortical Representation of Taster Status: Reducing the Heterogeneity of Group fMRI...... 4295 Sally Eldeghaidy, Luca Marciani, Francis McGlone, Tracey Hollowood, Joanne Hort, Kay Head, Andy Taylor, Johanneke Busch, Jason Stokes, Robin Spiller, Penny Gowland, Susan Francis

Functional MRI of Central Motor Drive During Muscle Contractions ...... 4296 Jill M. Slade, Sean C. Forbes, Ryan M. Francis, Robert W. Wiseman, Ronald A. Meyer

Heart-Rate Based Analysis of fMRI Data Can Reveal 'lost' Signal Intensity Changes in the Spinal Cord Associated with Distinct Phases of the Human Sexual Response ...... 4297 Natalie Kozyrev, Chase R. Figley, Patrick W. Stroman

Cortical Responses to a Rectal Balloon Pain Paradigm...... 4298 Luca Marciani, David Humes, Kay Head, Tom White, Jan Smith, Debbie Bush, Matt Brookes, Claire Stevenson, Peter G. Morris, Robin C. Spiller, Penny A. Gowland, Sue T. Francis

Faces Around the Norm – fMRI of the Face Distortion Aftereffect ...... 4299 Peter Dechent, Carmen Morawetz, Jürgen Baudewig, Stefan Treue, Mike Webster, Daniel Kaping

Functional MRI of Visual Development in Rat Superior Colliculus ...... 4300 Kai Xing, Kevin C. Chan, Matthew M. Cheung, Ed X. Wu

BOLD Impulse Response Functions in the Somatosensory Cortex: Implications for CMRO2 Calculation ...... 4301 Peter Herman, Basavaraju G. Sanganahalli, Hal Blumenfeld, Fahmeed Hyder

Sensory Integration Studies in Rodent by fMRI: Intra- And Inter-Hemispheric Effects...... 4302 Basavaraju G. Sanganahalli, Peter Herman, Hal Blumenfeld, Fahmeed Hyder

Comparision of α-Chloralose and Domitor Anesthesia for fMRI and Electrophysiology Studies...... 4303 Basavaraju G. Sanganahalli, Peter Herman, Hal Blumenfeld, Fahmeed Hyder

Estrogen Increases Hippocampal Activity and Functional Connectivity in Postmenopausal Women...... 4304 Sijia Gao, Ke Xu

Sensory-Induced Sub-Cortical Activations in Rat Brain by fMRI ...... 4305 Basavaraju G. Sanganahalli, Peter Herman, Christopher J. Bailey, Douglas L. Rothman, Fahmeed Hyder,

MR Perfusion of Non-Small Cell Lung Cancer in Transgenic SCID Mice Overexpressing VEGF ...... 4306 Yeun-Chung Chang, Ang Yuan, Yi-Chien Lu, Jyh-Horng Chen, Pan-Chyr Yang

An Investigation Into the Effects of Anaesthesia Upon Regional Functional Modulation in the Rat Brain: A phMRI Study ...... 4307 Tamsin A. Langley, Nick Jones, Michael J. O'Neill, Steve C.R. Williams

Functional Connectivity Networks Associated with Dorsal and Ventral Striatum ...... 4308 Aman Goyal, Wendy Ringe, Kaundinya Gopinath, Robert Haley, Richard Briggs

Modulation of BOLD-Response in the Hypothalamus by Affectively Loaded Visual Stimuli ...... 4309 Florian Gerstl, Christian Windischberger, Karl Ægir Karlsson, Ewald Moser

Functional Imaging of Conditioned Nicotine Administration in an Animal Model of ADHD ...... 4310 Wei Chen, Joseph R. DiFranza, Wei Huang, Jean A. King

Functional Connectivity to Dorsal and Ventral Striatum Exhibit Different Dependencies on FcMRI Baseline Conditions...... 4311 Aman Goyal, Wendy Ringe, Kaundinya Gopinath, Lei Jiang, Robert Haley, Richard Briggs

Reliability of a Breath-Hold Paradigm to Characterise Inter-Subject Differences in Cognition Based Bold Contrast...... 4312 Marie Tisserand, Fernando Zelaya, Owen O'Daly, Alejandro Caceres, Laurence Reed, Mitul Mehta

Test-Retest Reliability Assessment for Longitudinal Studies Spanning a Major MRI System Upgrade...... 4313 Claudine Gauthier, Cécile Madjar, Oury Monchi, Julien Doyon, Richard D. Hoge

Concurrent Electromyography Guided fMRI Analysis to Improve Detection and Reduce Inter-Session Variability of the Measured Cortical Response to Ankle Dorsiflexion ...... 4314 Samia Aboushoushah, Xia Lin, Richard Bowtell, Margaret Phillips, Cris Constantinescu, Susan Francis

Repetition-Related Neural Plasticity: Common Memory Mechanisms in Birds and Humans ...... 4315 Colline Poirier, Tiny Boumans, Marleen Verhoye, Jacques Balthazart, Annemie Van der Linden

Detecting Clinically Significant Subtle Myocardial Damage in Myocardial Infarction Using Multi-Contrast Delayed Enhancement MRI: Correlation with Whole-Mount Heart Histology at Micron-Level Resolution ...... 4316 Yuesong Yang, Jay S. Detsky, Mihaela Pop, Alexander J. Dick, Graham A. Wright

Improved Method for Assessing Myocardial Infarction in Rodents at 9.4T Using Delayed Enhancement-MRI...... 4317 Anthony N. Price, Kenneth K. Cheung, Mark F. Lythgoe

Myocardial Infarction Quantification and Function Assessment with Manganese Enhanced MRI (MEMRI) in Mice on a Clinical 3T Scanner ...... 4318 Benedicte Delattre, Vincent Braunersreuther, Jean-Noël Hyacinthe, François Mach, Jean-Paul Vallée

Visualization of Myocardial Inflammation in Experimental Autoimmune Myocarditis Rats Detected by MR Imaging with a Magnetofluorescent Nanoparticles...... 4319 Hyeyoung Moon, Hyo Eun Park, Quan-Yu Cai, Cheongsoo Park, Ki-Bae Seung, Kiyuk Chang, Kwan Soo Hong

Hybrid Adiabatic-Rectangular Pulse Train for Effective Saturation of Magnetization Within the Whole Heart at 3T...... 4320 Daniel Kim, KellyAnne McGorty

Oxygen Inhalation Reduces Left Ventricular Perfusion and Cardiac Output Measured by Magnetic Resonance Imaging ...... 4321 Marcus Carlsson, Stefan Bodetoft, Hakan Arheden, Ulf Ekelund

Cine-EPI Can Be Used to Detect Adenosine-Induced Myocardial Oxygenation Changes in Canines ...... 4322 Jordin Daniel Green, Matthias Voehringer, Jacqueline A. Flewitt, Sven Zuehlsdorff, John Victor Tyberg, Matthias G. Friedrich

Malignant and Benign Cardiac Tumors: Differentiation by MR Perfusion Assessment...... 4323 Kerstin Ulrike Bauner, Steven Sourbron, Michael Schmoeckel, Maximilian F. Reiser, Armin M. Huber

The Athlete's Heart - Gender Aspects...... 4324 Katarina Steding, Torsten Buhre, Björn Wohlfart, Henrik Engblom, Henrik Mosén, Bo Hedén, Håkan Arheden

Feasibility of Real-Time Cine to Detect Exercise-Induced Cardiac Wall Motion Abnormalities in Patients Suspected of Coronary Artery Disease ...... 4325 Mihaela Jekic, Jennifer Dickerson, Eric Foster, Beth McCarthy, Subha V. Raman, Orlando P. Simonetti

Feature Tracking of Cine MRI Images Identifies Left Ventricular Segments with Transmural Myocardial Scar...... 4326 Eva Maret, P-G Bjorklund, B-M Ahlander, Johan Kihlberg, Jan Ohlsson, Eva Swahn, Tim Todt, Jan Engvall

Quantification of Global Hypokinesis in Left Ventricle Using Center Point Trajectory (CPT) Mapping ...... 4327 Ting Song, Jeffrey A. Stainsby, Maureen N. Hood, Vincent B. Ho

An Intensity Based Statistical Approach for Left Ventricular Localization and Identification of End-Systolic and End-Diastolic Images from Cine Cardiac MRI...... 4328 Sotirios Athanasios Tsaftaris, Xiangzhi Zhou, Richard Tang, Rachel Klein, Rohan Dharmakumar

Automatic Computation of Ejection Fraction Using Temporal Intensity Information ...... 4329 Amol Pednekar, Mercedes Pereyra, Brenda Lambert, Debra Dees, Benjamin Cheong, Raja Muthupillai

Automated Recognition of Abnormal Left Ventricle Wall Motion ...... 4330 YingLi Lu, Perry Radau, Kim A. Connelly, Alexander Dick, Graham A. Wright

Polar-Regularized Left Ventricular Strain Analysis from Cine MRI Using Non-Rigid Registration...... 4331 Wei Feng, Himanshu Gupta, Steven G. Lloyd, Louis J. Dell'Italia, Thomas S. Denney Jr.

Quantitative MRI in the Detection of Cardiac Iron in Patients with Thalassemia...... 4332 Jin Yamamura, Regine Grosse, Rainer Engelhardt, Joachim Graessner, Gregory Kurio, Roland Fischer, Gritta E. Janka, Gerhard Adam

Heart and Liver R2 and R2 Measurements in Patients with Thalassaemia Major at 3T...... 4333 Hua Guo, Wing-Yan Au, Jerry S. Cheung, Jens H. Jensen, Daniel Kim, Pek-Lan Khong, Queenie Chan, Christina Tosti, Haiying Tang, Truman R. Brown, Wynnie W.M. Lam, Shau-Yin Ha, Gary M. Brittenham, Ed X. Wu

Multi-Centre Validation of the Magnetic Resonance T2 Technique for Segmental and Global Quantification of Myocardial Iron...... 4334 Vincenzo Positano, Anna Ramazzotti, Alessia Pepe, Giuseppe Rossi, Cristina Salvatori, Antonella Meloni, Daniele De Marchi, Brunella Favilli, Luigi Natale, Eliana Cracolici, Gennaro Restaino, Gianluca Valeri, Antongiulio Luciani, Luigi Landini, Massimo Lombardi

R2 Imaging of Ferritin Iron in Thalassemic Patients Off and on Iron-Chelation Therapy ...... 4335 Daniel Kim, Jens H. Jensen, Christina L. Tosti, Ed X. Wu, Sujit S. Sheth, Truman R. Brown, Gary M. Brittenham

Single-Breathhold Myocardial T2 and T2 Quantification in Normal Volunteer Subjects at 3T ...... 4336 Hua Guo, Jerry S. Cheung, Daniel Kim, Pek-Lan Khong, Gary M. Brittenham, Ed X. Wu

Is Hemorrhage in Acute Reperfused Myocardial Infarction a New Marker for the Severity of Tissue Injury? ...... 4337 Andreas Kumar, Jordin D. Green, Jane M. Sykes, Andrea J. Mitchell, Gerald Wisenberg, Matthias G. Friedrich

Assessment of Cardiac Iron and Right Ventricular Function by GRE-MRI in Patients with Thalassemia and Sickle Cell Disease...... 4338 Jin Yamamura, Regine Grosse, Rainer Engelhardt, Joachim Graessner, Gregory Kurio, Roland Fischer,Gritta E. Janka, Gerhard Adam

Visualizing and Quantifying Myocardial Oxygenation Changes with Statistically Optimal Colormaps...... 4339 Sotirios Athanasios Tsaftaris, Richard Tang, Rachel Klein, Debiao Li, Rohan Dharmakumar

Optimization and Validation of a Modified Look-Locker Saturation-Recovery (MLLSR) Sequence Applied to Cardiac T1 Mapping ...... 4340 Ting Song, Maureen N. Hood, Vincent B. Ho, Sandeep N. Gupta, Jeffrey A. Stainsby

Myocardial Fat Quantification Using Two-Point Water-Fat Imaging with Simultaneous T2 Correction ...... 4341 Chia-Ying Liu, Alban Redheuil, Ronald Ouwerkerk, Joao Lima, David Bluemke

Myocardial Fibro-Fatty Infiltration in Duchenne Muscular Dystrophy Canine Model Detected Using Multi-Echo Dixon Method of Water and Fat Separation Imaging...... 4342 Peter Kellman, Diego Hernando, Saurabh Shah, Robert F. Hoyt Jr. , Robert M. Kotin, Bruce W. Keene, Joe N. Kornegay, Anthony H. Aletras, Andrew E. Arai

Myocardial Lipid Accumulation Due to High Fat Diet in PPAR-Alpha Overexpressing Mouse Hearts Reduces Endocardial 2-D Principal Strains ...... 4343 Janusz H. Hankiewicz, Natasha H. Banke, E. Douglas Lewandowski

The Accuracy of Myocardial T2-Mapping Techniques ...... 4344 Shivraman Giri, Georgeta Mihai, Yiu-Cho Chung, Orlando P. Simonetti

An Accurate and Quantitative T2 Mapping Technique to Detect Myocardial Edema in Acute Coronary Syndrome ...... 4345 Shivraman Giri, Georgeta Mihai, Ali Merchant, Xiaoming Bi, Yiu-Cho Chung, Tam Tran, Subha V. Raman, Orlando P. Simonetti

Diffusion Spectrum MRI Tractography Reveals the Presence of a Complex Network of Residual Myofibers Within Infarcted Myocardium...... 4346 David Sosnovik, Ruopeng Wang, Guangping Dai, Teresa Wang, Elena Aikawa, Mikhail Novikov, Anthony Rosenzweig, Richard Gilbert, Van Wedeen

Evaluation of Acute Myocardial Ischemia Gene Therapy Efficacy Using Diffusion Tensor Imaging ...... 4347 Osama M. Abdullah, James W. Yockman, Catherine M. Straub, N Hu, A Albinil, S W. Kim, David A. Bull, Edward W. Hsu

Spatio-Temporal Modeling of First-Pass Perfusion Cardiovascular MRI ...... 4348 Volker J. Schmid, Guang-Zhong Yang

Automated Myocardial Segmentation for Quantitative Analysis of First-Pass Cardiac Perfusion MRI ...... 4349 Qi Duan, Ricardo Otazo, Daniel Kim, Daniel K. Sodickson

A Parametric Model for Quantitative Analysis of Contrast-Enhanced First-Pass MR Myocardial Perfusion That Accounts for Gd-DTPA Interstitial Loading...... 4350 Li-Yueh Hsu, Daniel W. Groves, Anthony H. Aletras, Peter Kellman, Andrew E. Arai

Coregistration and Visualization of Regionally Perfused Myocardium from First- Pass Multislice Sets Based on Independent Components Analysis ...... 4351 Ahmet E. Sonmez, Julien Milles, Zhigang Deng, Nikolaos V. Tsekos

In Vivo Cardiac NMR Diffusion Weighted Imaging(DWI) for the Human Heart: Improved Quantification of FA and MD by Edge-Preserving Regularization...... 4352 Carole Frindel, Stanislas Rapacchi, Marc Robini, Han Wen, Magalie Viallon, Laurent Fanton, Pierre Croisille

Right Ventricular Three-Dimensional Architecture, Assessed with DTMRI, Is Preserved During Experimentally Induced Right Ventricular Hypertrophy...... 4353 Eva Amalie Nielsen, Morten Smerup, Peter Agger, Jesper Frandsen, Michael Pedersen, Steffen Ringgaard, Peter Vestergaard, Jens Randel Nyengaard, Johnnie Bremholm Andersen, Paul P. Lunkenheimer, Robert H. Anderson, Vibeke Hjortdal

In Vivo Murine Cardiac PCr and ATP Concentrations Measured by Magnetic Resonance Imaging and Spectroscopy...... 4354 ashish gupta, V. P. Chacko, Robert G. Weiss

Early Diagnosis of Myocardial Infarction Areas on Rat Models Using 2D 31P CSI ...... 4355 Ziqi Sun, Tiansheng Wang, Guanglong He, Jay L. Zweier

Cardiac Phase-Resolved 3D SSFP Myocardial BOLD Imaging in Canines with Coronary Artery Stenosis...... 4356 Xiangzhi Zhou, Sven Zuehlsdorff, Saurabh Shah, Richard Tang, Rachel Klein, Debiao Li, Rohan Dharmakumar

Quantification of Myocardial Oxygen Consumption Rate: Initial Experience in Humans ...... 4357 Kyle Stephan McCommis, Donna Lesniak, Thomas A. Goldstein, Pamela K. Woodard, Robert J. Gropler, Jie Zheng

T2 Preparation Methods for the Quantification of Myocardial Oxygenation at Rest and During Hyperemia ...... 4358 Kyle Stephan McCommis, Robert O'Conner, Dana R. Abendschein, Bernd Misselwitz, Robert J. Gropler, Jie Zheng

Dependence of Myocardial BOLD Contrast on Imaging Parameters at 1.5T: Monte Carlo Simulation and Experiments ...... 4359 Xiangzhi Zhou, Richard Tang, Rachel Klein, Debiao Li, Rohan Dharmakumar

Use of Susceptibility Mapping to Detect Suspicious Dark Rim Artefacts During Perfusion MRI...... 4360 Gopal Varma, Timothy Lockie, Julien Senegas, Stephen Keevil, Sven Plein, Tobias Schaeffter

Variability of Perfusion Dark Rim Artifacts Due to Gibbs Ringing...... 4361 Pedro Ferreira, Peter Gatehouse, Peter Kellman, Chiara Bucciarelli-Ducci, David Firmin

Realistic Simulations on the Dark Rim Artifact for Myocardial Perfusion Protocols ...... 4362 Pedro Ferreira, Peter Gatehouse, Peter Kellman, David Firmin

Quantification of Myocardial Perfusion with an Undersampled Radial Acquisition...... 4363 T. H. Kim, N. Pack, G. Adluru, E. V.R. DiBella

Wall Shear Stress Measurement Error in the Common Carotid Artery: A Dual Modality Study ...... 4364 Alex J. Barker, Fuxing Zhang, Philip E. Gates, Luciano A. Mazzaro, Jonathan Fulford, Craig J. Lanning, Robin Shandas

In-Plane PC-MRI as a Tool for Verification of Non-Newtonian CFD Models of the Flow in Cerebral Aneurysms ...... 4365 Vitaliy L. Rayz, Loic Boussel, Alastair J. Martin, Gabriel Acevedo-Bolton, Joe R. Leach, Randall T. igashida, Michael T. Lawton, William L. Young, David Saloner

Computer-Aided Method for Automated Selection of Optimal Imaging Plane for easurement of Cerebral Volumetric Blood Flow Rate by MRI...... 4366 Pang-Yu Teng, Noam Alperin

High-Resolution Time-Resolved 3D Quantitative Flow MRI of Intracranial Vessels...... 4367 Marco Piccirelli, Gérard R. Crelier, Roger Luechinger, Sebastian Kozerke, Peter Boesiger

Pulse Wave Velocity in Patients with Bicuspid Aortic Valve and Normal Controls:Discriminatory Ability Among Multiple Analysis Techniques ...... 4368 Thananya Boonyasirinant, Randolph M. Setser, Prabhakar Raijiah, Milind Y. Desai, Scott D. Flamm

Measuring Effective Orifice Area in Patients After Aortic Valve Replacement Using Phase-Contrast Cine Magnetic Resonance Imaging ...... 4369 Haruhiko Machida, Eiko Ueno, Mikihiko Fujimura, Kazufumi Suzuki, Satoru Morita, Ai Masukawa, Masami Hirata, Shinya Kojima, Shoji Sasaki, Kiyoharu Nakano, Yoshiaki Komori

Assessment of Papillary Muscle Function Using MRI Tissue Tagging ...... 4370 Randolph M. Setser, Melanie S. Kotys, Thananya Boonyasirinant, Scott D. Flamm

Quantification of 3-Directional Motion of Papillary Muscle Using Tissue Velocity Mapping in Patients with Mitral Valve Prolapse...... 4371 Yuchi Han, Kraig V. Kissinger, Beth Goddu, Warren J. Manning, Reza Nezafat

Dynamic Evaluation of Lower Extremity Varicosities: Preliminary Experience with Isotropic Time-Resolved Direct Magnetic Resonance Venography (TR-MRV) at 3 Tesla...... 4372 Derek G. Lohan, Roya Saleh, Steven Hsu, Christopher Loh, Stephen T. Kee, Daniel Ennis, Gerhard Laub, J. Paul Finn

Reproducibility of MR Arteriography and Cine Phase-Contrast Flow Measurements in Peripheral Arterial Disease...... 4373 Bastiaan Versluis, Marcelle van Eupen, Patty J. Nelemans, Ellen V. Rouwet, Joep A.W. Teijink, Joachim E. Wildberger, Walter H. Backes, Tim Leiner

Time-Resolved MR Angiography of the Distal Lower Extremities: Clinical Application, Vessel Diameters, and Contrast Dynamics ...... 4374 Gurpreet Singh Sandhu, Rod P. Rezaee, Jeffrey L. Duerk, Mark A. Griswold, Vikas Gulani

Development of an MR Technique to Investigate the Effects of Respiration and Muscle Contraction on the Venous Blood Flow in the Lower Leg ...... 4375 Iain Thomas Pierce, Peter D. Gatehouse, David N. Firmin, Xiao Yun Xu, Andrew D. Scott

Quantitative Evaluation of Magnetohydrodynamic Effects on the Electrocardiogram...... 4376 Mihaela Jekic, Roger Dzwonczyk, Yu Ding, Subha V. Raman, Orlando P. Simonetti

Eddy Current Corrections for Phase Contrast MRI Using Gradient Calibration ...... 4377 Kevin Michael Johnson, Darren Lum, Oliver Wieben

Anti-Aliasing Acquisition (AAA) Decreases Study Duration While Maintaining Accuracy in Cardiac MR Flow Exams...... 4378 Jordin Daniel Green, David John Patton, Qing-San Xiang

Improved SNR in Phase Contrast Velocimetry with 5-Point Balanced Flow Encoding ...... 4379 Kevin Johnson, Michael Markl

Cardiac-Specific GLUT1 Overexpression Preserves Contractile Reserve in Diabetic Mouse Hearts: A Multi-Phase DENSE MRI Study Under Dobutamine-Induced Cardiac Stress ...... 4380 Jia Zhong, Fang Bian, Wei Li, Priyanjana Chaudhuri, Rong Tian, Xin Yu

2D Multi-Phase DENSE MRI with Direct Quantification of Lagrangian Strain in Mouse Hearts ...... 4381 Jia Zhong, Xin Yu

Theoretical Validation of Fast Cine DENSE MRI for Quantification of Regional Cardiac Function ...... 4382 Li Feng, Daniel Kim

Comparison of 2D and 3D Torsion Measured from Tagged Cardiac MRI...... 4383 Bharath Ambale, Steven Lloyd, Himanshu Gupta, Louis Dell'Italia, Thomas Stewart Denney Jr.

Does Surgical Intervention for Myocyte Transfection Impact on Cardiac Function in Mice? ...... 4384 Erica Dall'Armellina, Craig A. Lygate, Hannah Barnes, Ricardo Carnicer, Stefan Neubauer, Michael Markl, Bernd A. Jung, Jurgen E. Schneider

Tissue Phase Mapping Reveals Profound Alterations of Segmental Left Ventricular Performance in Patients with Cardiomyopathy and Left Bundle Branch Block ...... 4385 Daniela Foell, Bernd Jung, Elfriede Schilli, Felix Staehle, Christoph Bode, Juergen Hennig, Michael Markl

Analysis of Segmental Diastolic Asynchrony in Patients with LV Hypertrophy Using Tissue Phase Mapping...... 4386 Daniela Foell, Michael Markl, Elfriede Schilli, Felix Staehle, Christoph Bode, Juergen Hennig, Bernd Jung

Changes in Longitudinal and Radial Strain After Coronary Embolization Detected on Velocity Encoded Phase Contrast Magnetic Resonance Imaging ...... 4387 Marcus Carlsson, Demetrius Dicks, Einar Heiberg, Alastair Martin, David Saloner, Hakan Arheden, Maythem Saeed

Retrospective Enhancement of Radially Undersampled Cardiac Cine MR Images Using Prior Image Constrained Compressed Sensing (PICCS) ...... 4388 Christopher J. François, Jie Tang, Guang Hong Chen

Assessment of Left Ventricular Function with Single Breath-Hold Highly Accelerated Cine MRI Combined with Guide-Point Modeling...... 4389 Christina Heilmaier, Kai Nassenstein, Sonia Nielles-Vallespin, Sven Zuehlsdorff, Peter Hunold, Joerg Barkhausen

Local Noise Measurement in Real-Time Cardiac Cine MRI - A Random Matrix Approach ...... 4390 Yu Ding, Yiu-cho Chung, Orlando P. Simonetti

Denoising of Highly Accelerated Real-Time Cardiac MR Images Using Extended Non-Local Means...... 4391 Jean-Noël Hyacinthe, Benoit Naegel, Maurizio Tognolini, Jean-Paul Vallée,

High-Resolution Transmural 3D Myocardial Strains Using 3D Tissue Tagging with Optical Flow Tracking...... 4392 Chun Xu, Kevin Koomalsingh, Aaron S. Blom, Larry Dougherty, Gamaliel Isaac, Joseph H. Gorman, Robert C. Gorman, James J. Pilla

Mapping Myocardial Mechanical Activation by MRI Tagging and HARP ...... 4393 Martina Marinelli, Piergiorgio Masci, Daniele De Marchi, Massimo Lomabrdi, Luigi Landini,Vincenzo Positano

Comparison of 2D and 3D Calculation of Left Ventricular Torsion as Circumferential-Longitudinal Shear Angle Using MRI Tagging ...... 4394 Iris K. Rüssel, Sandra R. Tecelão, Joost P. Kuijer, J Tim Marcus

Very High Temporal Resolution (<10 Ms) Cine-EPI for Myocardial Tagging Is Feasible and Has More Persistent Tag Lines Than a Conventional Gradient Echo Sequence ...... 4395 Jordin Daniel Green, Renate Jerecic, Andreas Kumar, Oliver Strohm, Sonia Nielles-Vallespin, Sven Zuehlsdorff

Respiratory Self-Gating with 3D-Translation Compensation for Whole-Heart Coronary MRA...... 4396 Peng Lai, Xiaoming Bi, Renate Jerecic, Debiao Li

Free-Breathing Versus Breath-Hold 32-Channel Coronary Vessel Wall Imaging at 3T...... 4397 Andrea J. Wiethoff, John J. Totman, Rene M. Botnar, Matthias Stuber

Coronary Artery Distensibility Assessed by 3.0 T Cardiac MRI...... 4398 Sebastian Kelle, Allison G. Hays, Glenn A. Hirsch, Gary Gerstenblith, Robert G. Weiss, Matthias Stuber

Coronary Artery Imaging at 3T Using a Novel ECG Gated SSFP-Dixon Sequence and a Motion Insensitive View Ordering Scheme ...... 4399 Manojkumar Saranathan, Ersin Bayram, Vijay Nimbargi, Ramesh Venkatesan, James Glockner

Noninvasive in Vivo High-Resolution MRI of Vessels Affected by Transplant Rejection in Mice: As Good as Histopathological Analysis? ...... 4400 Andreas Hess, Julia Gehardt, Lubos Budinsky, Udo Reulbach, Stephan M. Ensminger

Coronary Artery Motion Analysis in Patients with Atrial Fibrillation Using Real-Time True FISP Cine Imaging to Reduce Artifacts in CT and MR Coronary Angiographies ...... 4401 Yoshiro Hori, Naoaki Yamada, Masahiro Higashi, Tadashi Watabe, Tetsuro Nakazawa, Atsushi Kono, Suzu Kanzaki, Tetsuya Fukuda, Hiroaki Naito

High-Resolution Ex-Vivo MR Angiography of the Murine Heart Using Langendorff Gd-DTPA Perfusion Technique ...... 4402 Steven F. Tanner, David Benoist, Justin F X Ainscough, Edward White, Michael E. Ries, Aleksandra Radjenovic

Accuracy and Reproducibility of Breath-Hold Velocity-Encoded MRI with Spiral K-Space Sampling in the Right Coronary Artery Using 3T MRI...... 4403 Anne Brandts, Stijntje D. Roes, Joost Doornbos, Albert de Roos, Matthias Stuber, Jos J.M. Westenberg

Design and Validation of an Accurate, Reproducible and MR Compatible Respiratory Motion Phantom for Use in Coronary Artery and General MR Imaging ...... 4404 Andrew David Scott, Jenny Keegan, David Firmin

Automatic Segmentation of 3D Phase Contrast MRI Using Velocity Guided Gradient Vector Flow...... 4405 Robert L. Janiczek, Frederick H. Epstein, Scott T. Acton

Validation of Finite-Element Stress Analysis of Abdominal Aortic Aneurysm Using Dynamic MRI...... 4406 Maarten Merkx, Marcel van 't Veer, Marcel Breeuwer, Lambert Speelman, Jaap Buth, Frans van de Vosse

Characterizing the Brain Arterial Hemodynamics with Subject-Specific MRABased Computational Fluid Dynamics Models...... 4407 Fernando Mut, Susan Wright, Giorgio Ascoli, Juan R. Cebral

Computational Fluid Dynamics (CFD)-Based Flow Analysis in Aneurysms: A Comparison Study with 4D Phase- Contrast MR in an in Vivo Canine Aneurysm...... 4408 Jingfeng Jiang, Kevin Johnson, Oliver Wieben, Oddrun Myklebust, Kent-Andre Mardal, Charles Strother

A 3D MRA Segmentation Method Based on Tubular NURBS Model ...... 4409 Avan Suinesiaputra, Patrick J H de Koning, Elena Zudilova-Seinstra, Johan H C Reiber, Rob J. van der Geest

Improved Cardiovascular Planning Strategies in Patients with Congenital Heart Disease ...... 4410 Israel Valverde, Tarinee Tangcharoen, Hubrecht de Bliek, Graeme Penney, Marcel Breeuwer, Tobias Schaeffter, Philipp Beerbaum, Reza Razavi, Gerald F Greil

Multimodality Imaging for Investigation of Plaque Morphology and Blood Flow: Preliminary Results...... 4411 Florence Trinity Baluyot, Vijay Shamdasani, Hunter Underhill, Baocheng Chu, William S. Kerwin,Chun Yuan

MR Plaque Image: Prediction of the Complication Risk at Carotid Artery Stenting...... 4412 Masahiko Sakamoto, Toshiaki Taoka, Hiroyuki Nakagawa, Ktsutoshi Takayama, Takeshi Wada, Kaoru Myouchin, Toshiteru Miyasaka, Toshiaki Akashi, Kimihiko Kichikawa

Hemorrhage in Carotid Plaque Is Not a Predictive Marker of New Cardiovascular Events in Asymptomatic Individuals•FA High-Resolution MRI Study ...... 4413 Jianming Cai, Qingjun Wang, Lin Ma, Youquan Cai, Qian Zhao

Distribution of Intraplaque Calcification in the Femoral Artery: A Multi-Contrast MRI Study ...... 4414 Feiyu Li, Chun Yuan, Marina Ferguson, Dongxiang Xu, Xihai Zhao, Mary McGrae McDermott

Carotid Contrast Enhanced MRA as a Measurement of Atherosclerosis Severity: Direct Comparison with High- Resolution Vessel Wall Imaging...... 4415 Li Dong, Hunter Underhill, Vasily L. Yarnykh, Wei Yu, Hideki Ota, Xihai Zhao, Thomas S. Hatsukami, Zhaoqi Zhang, Chun Yuan

High-Resolution Black-Blood Contrast-Enhanced T1-Weigthed Images for the Diagnosis of Intracerebral Arteritis: Preliminary Results...... 4416 Tobias Saam, Clemens C. Cyran, Katja Bochmann, Olaf Dietrich, Maximilian F. Reiser, Konstantin Nikolaou

In Vivo Differentiation of Two Vessel Wall Layers in Lower Extremity Peripheral Vein Bypass Grafts: Application of High Resolution Inner-Volume Black Blood 3D FSE ...... 4417 Dimitris Mitsouras, Christopher D. Owens, Michael S. Conte, Hale Ersoy, Mark A. Creager, Frank J. Rybicki, Robert V. Mulkern

Three-Dimensional T2-Weighted TSE MRI of the Human Femoral Arterial Vessel Wall at 3.0Tesla...... 4418 Zhuoli Zhang, Zhaoyang Fan, Timothy Carroll, Yiu-Cho Chung, Renate Jerecic, Peter Weale,Debiao Li

In Vivo Contrast-Enhanced (Gd-DTPA) and Ex Vivo Magnetization Transfer and Diffusion Weighted MRI Detect Changes in Thrombus Composition During Propagation from Sites of Disrupted Atherosclerotic Plaques...... 4419 Alkystis Phinikaridou, Kevin J. Hallock, Ye Qiao, James A. Hamilton

Phantom Investigation on the Accuracy of Different Pulse Sequences for the Determination of Arterial Distensibility...... 4420 Valentina Taviani, Andrew James Patterson, Pauline Wong, Michael P. Sutcliffe, Martin John Graves, Jonathan Harvey Gillard

Correlation Between Plaque Eccentricity and Vessel Remodeling in the Human Femoral Artery: A Morphology Investigation by High Resolution MRI ...... 4421 Feiyu Li, Mary McGrae McDermott, Marina Ferguson, Dongxiang Xu, Xihai Zhao, Chun Yuan

Multistation Non-Contrast Black Blood Angiography for the Diagnosis of Peripheral Arterial Disease...... 4422 Georgeta Mihai, Yiu-Cho Chung, Mbabazi Kariisa, Jessica West, Orlando P. Simonetti, Sanjay Rajagopalan

Clinical Assessment of Motion Sensitized Driven Equilibrium (MSDE) Prepared T1W 3D Vessel Wall Imaging at 3.0T for Soft Plaque Screening...... 4423 Makoto Obara, Masatoshi Honda, Yutaka Imai, Marc Van Cauteren, Kagayaki Kuroda

T2 Mapping to Differentiate Slow Flowing Blood from Vessel Wall...... 4424 Ryan Brown, Thanh D. Nguyen, Pascal Spincemaille, Grace Choi, Matthew D. Cham, Priscilla A. Winchester, Martin R. Prince, Yi Wang

Negative Magnetic Resonance Contrast of Peri-Aortic Lymph Nodes Created by Uptake of Ultrasmall Superparamagnetic Particles of Iron Oxide (USPIOs) May Mask the Aortic Lumen and Lead to False Positive Results with Regard to the Diagnosis of Atherosclerosis...... 4425 Bernard C. te Boekhorst, Sandra M. Bovens, Marcel G. Nederhoff, Kees W. van de Kolk, Maarten J. Cramer, Matthijs F. van Oosterhout, Michiel ten Hove, Pieter A. Doevendans, Gerard Pasterkamp, Cornelis J. van Echteld

Dynamic Contrast-Enhanced MRI Detects Progression of Inflammation in a Rabbit Model of Atherosclerosis ...... 4426 William Sean Kerwin, Jerry Ricks, Michael Rosenfeld

Detection of Time Delay for Aortic Compliance Evaluation ...... 4427 Yi Wang, Jianping Zhang, Edwin Estrada, Jing Han, Nathaniel Reichek,

The Pulmonary Blood Volume Varies Throughout the Cardiac Cycle in Healthy Subjects – a Novel Method for Quantification by MRI...... 4428 Martin Ugander, Erik Jense, Hakan Arheden

Optimized Data Analysis for the Assessment of Aortic Pressure Difference Maps...... 4429 Jelena Bock, Alex Frydrychowicz, Kevin Michael Johnson, Oliver Wieben, Jürgen Hennig, Michael Markl

Interactive Visualization and Analysis of Complex Flow Patterns in Congenital Heart Disease...... 4430 Ben Landgraf, Christopher J. Francois, Oliver Wieben, Elizabeth Janus Nett, Kevin M. Johnson

Blood Flow in the Healthy Aorta: Turbulent or Not?...... 4431 Aurelien F. Stalder, Alex Frydrychowicz, Max F. Russe, Jan G. Korvink, Jürgen Hennig, Michael Markl

Improved Aortic Pulse Wave Velocity Assessment with Inplane Velocity-Encoded MRI: Validation and Reproducibility ...... 4432 Jos J.M. Westenberg, Dennis Hendriksen, Paul Steendijk, Rob J. van der Geest, Heynric B. Grotenhuis, Maarten Groenink, J W. Jukema, Albert de Roos, Johan H.C. Reiber

Three-Dimensional Assessment of Wall Shear Stress Distribution in the Atherosclerotic Aorta...... 4433 Andreas Harloff, Andrea Nußbaumer, Simon Bauer, Aurelien F. Stalder, Alex Frydrychowicz, Cornelius Weiller, Jürgen Hennig, Michael Markl

Assessment of Asymmetric Aortic Distention Using Balanced Transient Field Echo MR Imaging ...... 4434 Joffrey van Prehn, Koen L. Vincken, Joost A. van Herwaarden, Sara M. Sprinkhuizen, Max A. Viergever, Frans L. Moll, Lambertus W. Bartels

3D Flow Characteristics in a Patient Specific Aortic Aneurysm Vessel Model: Comparison with In-Vivo Results...... 4435 Ramona Lorenz, Jelena Bock, Aurélien F. Stalder, Christoph Benk, Jürgen Hennig, Michael Markl

Visualization and Quantification of 3D Flow Characteristics in the Portal Venous System ...... 4436 Zoran Stankovic, Alex Frydrychowicz, Aurelien Stalder, Jelena Bock, Elisabeth Panther, Maximilian Russe, Juergen Hennig, Mathias Langer, Michael Markl

Perfusion MRI for Monitoring Therapy Effects in Experimental Chronic Limb Ischemia...... 4437 Harald Kramer, Steven Sourbron, Rabea Hinkel, Franziska Globisch, Christian Kupatt-Jeremias, Maximilian F. Reiser, Bernd J. Wintersperger

4D Spiral Phase-Contrast MRI of Wall Shear Stress in the Mouse Aorta ...... 4438 Robert L. Janiczek, Craig H. Meyer, Scott T. Acton, Brett R. Blackman, Frederick H. Epstein

MR-Driven Computational Fluid Dynamics ...... 4439 Jon-Fredrik Nielsen, Krishna S. Nayak

4D Flow Evaluation of Abnormal Systolic Flow Patterns with Bicuspid Aortic Valve...... 4440 Michael D. Hope, Thomas A. Hope, Alison K. Meadows, Karen G. Ordovas, David Saloner, Marcus T. Alley, Charles B. Higgins

Extending 4D Flow Visualization to the Human Right Ventricle ...... 4441 Petter Dyverfeldt, Jonatan Eriksson, Andreas Sigfridsson, John-Peder E. Kvitting, Carljohan Carlhäll, Jan Engvall, Ann F. Bolger, Tino Ebbers

Reconstruction of Aortic Blood Flow Pattern After Thoracic Stent Graft Implantation ...... 4442 Volker Rasche, Gerard R. Crelier, Axel Bornstedt, Martin Hoffmann, Alexander Oberhuber, Ludger Sunder-Plassmann

Dynamic Contrast Enhanced MR Angiography (4D MRA) Ot the Thoracic Vessels- An Intravidual Comparison of Different K-Space Acquisition Strategies ...... 4443 Florian M. Vogt, Katja Seng, Peter Hunold, Stefan Maderwald, Armin deGreiff, Gerhard Laub, Jörg Barkhausen

Combining Sensitivity Encoding (SENSE) and Foldover Suppression to Overcome FOV Restrictions in Thoracic 3D CE-MRA...... 4444 Varaha Satya Sairam Tammisetti, Silke Potthast, Theodore J. Dubinsky, Gregory J. Wilson, Jeffrey Harold Maki

Time-Resolved MR Angiography in Evaluation and Mapping of Central Thoracic Veno-Occlusive Disease...... 4445 Kambiz Nael, Stefan G. Ruehm, Mayil Krishnam, Gerhad Laub, J Paul Finn

Fat-Suppressed Non-Contrast-Enhanced MR Angiography of Thorax: Comparison Between Navigator-Gated SSFP and Respiratory-Gated TSE Imaging...... 4446 Yasuo Amano, Katsuya Takahama, Yoshio Matsumura, Shinichiro Kumita

Leading Edge Fidelity in View-Shared Time-Resolved 3D MRA ...... 4447 Petrice Marie Mostardi, Clifton Haider, Philip Rossman, Stephen Riederer

Intraindividual Comparison of Contrast Enhanced Magnetic Resonance Angiography and Digital Subtraction Angiography of the Lower Extremities...... 4448 Johannes T. Heverhagen, Michael Augsten, Michael Burbelko, Anna-Christina Stamm, Marc O. Kalinowski, Klaus Klose

Peripheral Contrast-Enhanced MR Angiography Using a SNR and Timing Optimized Protocol: Evaluation of Patient Lower Extremity Hemodynamics in 48 Patients ...... 4449 Earl Michael Chester, George R. Oliveira, Gregory J. Wilson, Jeffrey Harold Maki,

Continuous Table Movement for Peripheral MRA with Matrix Coils at 3.0T ...... 4450 Harald Kramer, Peter Schmitt, Michael Zenge, Christian Glaser, Maximilian F. Reiser, Karin A.Herrmann

Comprehensive Magnetic Resonance Evaluation of Vascular Malformations at 3T: Comparison of Time-Resolved Angiography with Interleaved Stochastic Trajectories (TWIST) with Standard 3D Contrast Enhanced MR Angiography (CeMRA)...... 4451 Ehab Ahmed Abdel-Gawad, Patrick T. Norton, Ahmed Mohamed Housseini, Ismaeel Mohammad Maged, klaus D. Hagspiel

Dedicated Calf MRA at 3T: Comparison of Time-Resolved MR Angiography with Interleaved Stochastic Trajectories (TWIST) with Standard High-Resolution 3D Contrast Enhance MR Angiography (HR CeMRA) ...... 4452 Ismaeel M. Maged, Patrick T. Norton, Ugur Bozlar, Ehab A. Abdel-Gawad, Ahmed Mohamed Housseini, Kenneth J. Cherry, Klaus D. Hagspiel

Time Resolved Peripheral MRA: Correlation with Functional Lower Limb Impairment...... 4453 Aoife N. Keeling, Cormac Farrelly, John Sheehan, William Pearce, Timothy J. Carroll, Mary M. McDermott, James C. Carr

Time-Resolved MRA Using Sliding Window Reconstruction for Evaluation of Renal Arterial Anatomy and Perfusion...... 4454 Aoife N. Keeling, Ravi K. Singh, Cormac Farrelly, Hyun Jeong, Ty A. Cashen, John Sheehan, James C. Carr, Timothy J. Carroll

Contrast-Enhanced Magnetic Resonance Angiography (CE-MRA) for Detection of Reperfused Pulmonary Arteriovenous Malformations (PAVM) After Coil Embolization in Patients with Hereditary Hemorrhagic Telangiectasia (HHT) ...... 4455 Guenther Schneider, Alexander Massmann, Peter Fries, Marcus Katoh, Urban Geisthoff, Arno Buecker

Time-Resolved MR Angiography for Assessment of Pulmonary Hypertension in Patients with Congenital Heart Disease...... 4456 Amir Hossein Davarpanah, John J. Sheehan, Timothy J. Carroll, James C. Carr

Comprehensive Magnetic Resonance Imaging of the Hand and Forearm Vasculature at 3 Tesla Using Time- Resolved Angiography with Stochastic Trajectories (TWIST): Preliminary Clinical Results...... 4457 Thomas Efren Huerta, Patrick T. Norton, B Chhabra, D B. Drake, P B. Arnold, Ahmed Mohamed Housseini, Klaus D. Hagspiel

High Resolution Non Contrast Enhanced MRA of the Hand Arteries at 3 Tesla Using an ECG-Triggered Variable Flip Angle 3D Fast Spin Echo (SPACE) Sequence ...... 4458 Ruth P. Lim, Pippa Storey, Iliyana P. Atanasova, Jian Xu, Elizabeth M. Hecht, David R. Stoffel, Hugo Chang, Kellyanne Mcgorty, Qun Chen, Henry Rusinek, H Michael Belmont, Vivian S. Lee

Dynamics of Contrast Agents in MRA: Analytical Basis and Experimental Validation ...... 4459 Abbas Nasiraei Moghaddam, Tariq Balawi, Reza Habibi, Gerhard Laub, J. Paul Finn

Potential Bias on Measurement of Atherosclerotic Stenosis: The Implication from Calibrations at Various Positions Along Arteries ...... 4460 Kai Lin, Zhao-qi Zhang, Biao Lu, Zhan-ming Fan

Validation of 3D-CEMRA with 2D ARC Acceleration in a Porcine Study ...... 4461 Christopher J. François, Mark L. Schiebler, Scott B. Reeder, Oliver Wieben, Reed F. Busse, Jean H. Brittain, Thorsten A. Bley

In Vivo 3D MR Angiography Reveals Accelerated Collateral Vessel Growth in CD73-/- Mice After Hindlimb Ischemia...... 4462 Ulrich Flögel, Yang Chul Böring, Christoph Jacoby, Jürgen Schrader

Optimisation of the Contrast Dose and Injection Rates in Whole Body Angiography at 3T ...... 4463 Shelley A. Waugh, Stephen J. Gandy, R Stephen Nicholas, Prasad Guntur Ramkumar, Baljit Jagpal, J Graeme Houston

Accelerated 3D Time-Resolved MR Angiography Using Cartesian HYPR LR Reconstruction...... 4464 Kang Wang, Jiang Du, Yijing Wu, Reed F. Busse, Kevin M. Johnson, Frank R. Korosec

Multicenter, Intraindividual Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine for MRA of the Peripheral Arteries ...... 4465 Tim Leiner, Suzanne Gerretsen, Thierry le Maire, Stephan Miller, Siegfried Thurnher, Christoph U. Herborn, Henrik Michaely, Harald Kramer, Angelo Vanzulli, Josef Vymazal, Martin Wasser

High Resolution Peripheral CE-MRA Featuring Continuous Table Movement (TimCT) and K-Space Segmentation: Initial Results ...... 4466 Michael O. Zenge, Sonja Kinner, Anton S. Quinsten, Harald H. Quick

Contrast-Enhanced MRA in the NSF Era: Potential for Contrast Dose Reduction...... 4467 Matthew J. Kuhn

Reducing Gd Dose for Moving Table MRA Using Cine-PC to Map Bolus Transit...... 4468 Grace Choi, Priscilla Winchester, Minh Chao, Yi Wang, Martin Raymond Prince

Comparison of Image Quality and Diagnostic Accuracy of 0.5 Molar Gadobenate Dimeglumine and 1.0 Molar Gadobutrol in Contrast-Enhanced Run Off MRA of the Lower Extremities ...... 4469 Johannes T. Heverhagen, Marina Achenbach, Jens Figiel, Christoph Weiss, Anna-Christina Stamm,Klaus Klose

LST-Based Optimization of Patient Specific Contrast Media Administration for CE-MRA: Validation Studies in Phantoms and Volunteers...... 4470 Daniel Kopeinigg, Dominik Fleischmann, Rudolf Stollberger, Roland Bammer

Blood-Pool Imaging Properties of Non Protein-Binding Extracellular Unspecific Gadolinium-Based Contrast Media ...... 4471 Patrick Asbach, Moritz Wagner, Matthias Rief, Matthias Taupitz, Bernd Hamm, Christian Klessen

First-Pass Whole-Body Magnetic Resonance Angiography at 3T with the Blood-Pool Contrast Agent Gadofosveset and the Extracellular Contrast Agent Gadoterate: A Randomized Study...... 4472 Yousef Wirenfeldt Nielsen

Blood Pool Enhanced MRA of Carotid Arteries: Added Value of Steady State Imaging...... 4473 Michele Anzidei, Alessandro Napoli, Beatrice Cavallo Marincola, Fulvio Zaccagna, Pier Luigi Di Paolo, Daniel Geiger, Chiara Zini, Carlo Catalano, Roberto Passariello

Whole-Body Imaging of Vascular Pathology in Fibulin-4 Mice Using Gd-Liposomes and Magnetic Resonance Angiography...... 4474 Piotr Alfred Wielopolski, Gerben Koning, Paula van Heijningen, Eric Kaijzel, Clemens Lowik, Monique Bernsen, Jeroen Essers

Flow-Sensitized Dephasing Prepared SSFP: A New Noncontrast MRA Technique ...... 4475 Zhaoyang Fan, John Sheehan, Xiaoming Bi, Rohan Dharmakumar, Renate Jerecic, James Carr, Debiao Li,

Non-Contrast Enhance MRA and Diffusion Weighted Imaging for a Non Invasive and Safe Morphological- Functional MR Study in Patients with Renal Insufficiency...... 4476 Isabelle Parienty, Francis Jouniaux, C C Fauré, D Maiza, A Prot, C Tavernier, G Rostoker, Faiza Admiraal-Behloul

Non Contrast-Enhanced 3D MR Angiography of Renal Arteries Using a Novel Inversion Recovery Steady State Free Precession Technique: Our Initial Experience...... 4477 Mayil Krishnam, Sachin Malik, Yutaka Natsuaki, Swati Deshmane, Derek Lohan, James Paul Finn, Stefan G. Ruehm, Gerhard Laub

Evaluation of the Renal Arteries: Comparison of Two Types of Non-Contrast MRA and Dynamic Contrast MRA...... 4478 Takayuki Masui, Motoyuki Katayama, Kimihiko Sato, Hiroki Ikuma, Hidekazu Seo, Megumi Ishii, Mitsuharu Miyoshi, Naoyuki Takei, Masayoshi Sugimura, Tetsuji Tsukamoto, Akihiko Kutsuna

Inhance (Inflow Inversion Recovery) Non-Contrast Renal MRA: Comparison with 3D Gadolinium Enhanced MRA in Clinical Patients ...... 4479 James F. Glockner, Naoki Takahashi, Akira Kawashima, David Woodrum, David W. Stanley, Naoyuki Takei, Mitsuharu Miyoshi, Sun Wei

Nonenhanced Renal MRA Using Time-SLIP with 3D Balanced SSFP: Optimization of Coronal Acquisition ...... 4480 Junji Takahashi, Sachiko Isono, Mitsue Miyazaki, Yoshinori Tsuji, Yusuke Hamada, Takashi Yoshida, Hiroshi Suzuki

Flow Inversion-Prepared Non-Contrast Enhancement in the Steady State (FINESS): A Novel SSFP-Dixon Technique for Non-Contrast MR Angiography of the Renal Arteries...... 4481 Manojkumar Saranathan, Ersin Bayram, Vijay Nimbargi, Ramesh Venkatesan, Naoyuki Takei, Mitsuharu Miyoshi, Wei Sun, James Glockner

Non-Contrast-Enhanced MR Portography Using Spin Labeling Technique: Comparison of Balanced SSFP and Half-Fourier FSE Sequence...... 4482 Hiroshi Sugimura, Kenichiro Yamaguchi, Ryuzo Ochiai, Eiji Furukoji, Tatefumi Sakae, Shozo Tamura, Toshiya Azuma, Tokunori Kimura, Yoko Tamaribuchi, Tatsuya Ohkubo, Yoshio Machida

Noncontrast MRA of Distal Lower Extremities Using Flow-Sensitized Dephasing Prepared SSFP...... 4483 Zhaoyang Fan, John Sheehan, Xiaoming Bi, Timothy J. Carroll, Renate Jerecic, James Carr, Debiao Li,

Highly Accelerated Non Contrast Enhanced MRA of the Lower Extremity Arteries at 3 Tesla Using an ECG- Triggered Variable Flip Angle 3D Fast Spin Echo (SPACE) Sequence...... 4484 Ruth P. Lim, Pippa Storey, Iliyana P. Atanasova, Danny C. Kim, Elizabeth M. Hecht, David R. Stoffel,Jian Xu, Qun Chen, Henry Rusinek, Vivian S. Lee

Evaluation of the Femoral Arteries: Before or After Tumor Treatments Using Non-Contrast MRA Using Subtraction Method Based on Velocity Encoding Technique ...... 4485 Takayuki Masui, Motoyuki Katayama, Mitsuharu Miyoshi, Kimihiko Sato, Hiroki Ikuma, Hidekazu Seo, Masayoshi Sugimura, Megumi Ishii, Naoyuki Takei, Tetsuji Tsukamoto

Nonenhanced MR Angiography of the Femoral Head Using Time-SLIP...... 4486 Jun Isogai, Mitsue Miyazaki, Takeshi Shimada, Hideo Hatakeyama, Takashi Yamada, Masashi Takeuchi, Shizuaki Maejima, Kenji Yodo, Tomoko Miyata

Non-Enhanced MR Angiography of the External Carotid Artery and Its Branches Using True Steady-State Free- Precession (SSFP) Sequence with Time Spatial Labeling Inversion Pulse (T-SLIP) Technique ...... 4487 Naoe Satogami, Tomohisa Okada, Takashi Koyama, Kimio Gotoh, Toshikazu Kamae, Kaori Togashi

Steady State MR Angiography of the Carotid Arteries: Are Intravascular Agents Necessary? a Feasibility Study to Evaluate the Potential of Gadobenate Dimeglumine for Combined First Pass and High-Resolution Steady State Vascular Imaging...... 4488 Alessandro Napoli, Carlo Catalano, Michele Anzidei, Roberto Passariello

Time-Efficient Artery and Vein Imaging in 3D TOF MRA of the Neck...... 4489 Amir Eissa, Alan H. Wilman

3D Time-Of-Flight MR Angiography with 2D Partial Fourier Techniques and Sensitivity Encoding for Improved Acceleration...... 4490 Yunhong Shu, Clifton R. Haider, John Huston, Stephen Riederer

Three Dimensional Phase Sensitive Inversion Recovery (PSIR) Turbo FLASH for Evaluation of Left Ventricular Myocardial Lesions in Infiltrative and Non-Ischemic Cardiac Diseases...... 4491 Aya Kino, Sven Zuehlsdorff, Aoife Keeling, Cormac Farrelly, John Sheehan, Peter Weale, Randal Ramsay, Terry Cunningham, Renate Jerecic, James C. Carr

1RR Phase Sensitive Inversion Recovery Late Gadolinium Enhancement MRI ...... 4492 Dana C. Peters, Daniel A. Herzka, Yuchi Han, Reza Nezafat, Basem Dokhan, Warren J. Manning

An Alternating Partial Fourier K-Space Segmentation Scheme for Imaging of Myocardial Delayed Enhancement ...... 4493 Dan W. Rettmann, Manojkumar Saranathan, Wei Sun, James Glockner

MADE: A Dark-Blood Delayed Enhancement Sequence to Improve Detection of Subendocardial Infarcts (Motion Attenuated Delayed Enhancement) ...... 4494 Michael Salerno, Frederick H. Epstein, Christopher M. Kramer

Low Dose Gadobenate Dimeglumine in Delayed Enhancement Cardiac MRI ...... 4495 Larry Allen Kramer, Roy Kumar, Sanjay Narotum, Catalin Loghin, Eduardo J. Matta, Anuradha T. Rao,Khader M. Hasan

A Saturation-Recovery Inversion-Recovery “black-Blood” GRE Sequence for Detection of Delayed Enhancement in the Assessment of Myocardial Infarction at 3.0 Tesla –Preliminary Results...... 4496 Kerstin Ulrike Bauner, Andreas F. Biffar, Martin Greif, Alexander Becker, Chistian Glaser, Maximilian F. Reiser, Armin M. Huber

Dark Blood Delayed Enhancement MRI for Evaluation of Myocardial Infarction and Non-Ischemic Cardiomyopathy in a Clinical Setting...... 4497 Cormac Farrelly, Wolfgang Rehwald, Aoife Keeling, John Sheehan, James Carr

Late Gadolinium Enhancement in Apparently Unenhanced Myocardium in Dilated Cardiomyopathy; Evaluation Using Myocardium to Lumen Ratio...... 4498 Atsushi Kono, Naoaki Yamada, Teruo Noguchi, Tadashi Watabe, Yoko Masukata, Yoshiro Hori

Phase-sensitive Reconstruction to Improve Visualization of Ablation Scar in Left Atrium Wall ...... 4499 E.G. Kholmovski, S. Vijayakumar, N.F. Marrouche

Early Enhancement with Gadobutrol Can Visualize Diffuse Myocardial Fibrosis in Dilated Cardiomyopathy : A Cardiovascular Magnetic Resonance Study ...... 4500 Oliver Strohm, Myra Sabene Cocker, Matthias G. Friedrich hp-GRAPPA for Delayed Enhanced Imaging of the Left Atrium ...... 4501 Sathya Vijayakumar, Nathan Burgon, Feng Huang, Eugene G. Kholmovski, Edward DiBella, Nassir F. Marrouche

Relationship Between Infarct Gray Zone and Characteristics of Ventricular Tachycardia Using Multi-Contrast Delayed Enhancement...... 4502 Jay Stephen Detsky, Gideon A. Paul, Kim A. Connelly, Alexander J. Dick, Graham A. Wright

Right Ventricular Involvement in Patients with Myocardial Infarction (MI): A Cardiac Magnetic Resonance (CMR) Study of Prevalence and Prognostic Implications ...... 4503 Iacopo Carbone, Marco Francone, Emanuela Algeri, Federica Ciolina, Ilaria Iacucci, Federica Vasselli, Carlo Catalano, Roberto Passariello

DE-MRI for Identifying the Ventricular Arrhythmia Substrate in Ischemic and Non-Ischemic Cardiomyopathy ...... 4504 Benoit Desjardins, Frank Bogun, Fred Morady

Assessment of Pericardial Inflammation Using Delayed Enhanced Phase-Sensitive Inversion-Recovery TurboFLASH...... 4505 Cormac Farrelly, Aoife Keeling, John Sheehan, Edward Wu, James Carr

In Vivo Contrast Enhanced MRI for Quantification of Cardiac Function and Infarct Size After Stem Cell Therapies in Mice ...... 4506 Leonie Paulis, Tessa Geelen, Alexandra Klein, Wilhelm Röll, Bernd Fleischmann, Klaas Nicolay, Gustav Strijkers

Magnetic Resonance Imaging Provides Non-Invasive Assessment of Pulmonary Hypertension Severity by Reduced Relative Area Change of the Pulmonary Artery...... 4507 Alejandro Roldán-Alzate, Scott B. Reeder, Jon G. Keevil, James R. Runo, Christopher J. Francois, Naomi C. Chesler

3D Contrast Enhanced MRA of the Pulmonary Arteries Using 2D Parallel Imaging (ARC); Rapid Single Breath Hold Pulmonary MRA in Patients with Dyspnea ...... 4508 Mark L. Schiebler, Scott K. Nagle, Scott B. Reeder, Christopher Francois, Dana Tudorascu, Reed F. Busse, Anja Brau, Jean H. Brittain, Thomas Grist

A Total Atherosclerotic Score for Whole Body MRA Is Related to Traditional Cardiovascular Risk Factors, IMT and Manifest Cardiovascular Disease ...... 4509 Tomas Hansen, Håkan Ahlström, Lars Lind, Johan Wikström, Lars Johansson

Quantification of Aortic Motion in Wild-Type and Apolipoprotein E-Deficient Mice Using Time Resolved MR Angiography: Possible Correlation Between Direction of Vessel Motion and Abdominal Aortic Aneurysm Bulging ...... 4510 Craig J. Goergen, Maj Hedehus, Charles A. Taylor, Philip S. Tsao, Joan M. Greve

Free-Breathing Whole-Heart 3D Cardiac MRI at 3.0 Tesla for Characterization of Interatrial Septum: A Comparison with Multislice Computed Tomography...... 4511 Abdalla A. Elagha, Roderic I. Pettigrew, Ahmed M. Gharib

Improved MRI Assessment of the Left Atrial Appendage Using Delayed Enhancement Imaging as Compared to Black Blood Fast Spin Echo Imaging...... 4512 Thanh D. Nguyen, Matthew D. Cham, Jason Chinitz, Pascal Spincemaille, James K. Min, Bruce B. Lerman, Martin R. Prince, Yi Wang, Jonathan W. Weinsaft,

Coronary Veins Imaging Using Free-Breathing Whole-Heart 3D Cardiac Magnetic Resonance Imaging (MRI) at 3.0 Tesla: A Comparative Study with Multi-Detector Computed Tomography (MDCT)...... 4513 Abdalla A. Elagha, Roderic I. Pettigrew, Ahmed M. Gharib

Quantification of Pulmonary Vein Off-Resonance Frequency Through the Cardiac Cycle: Implications for Non- Contrast Pulmonary Vein MRA ...... 4514 Peng Hu, Christian Stoeck, Dana C. Peters, Kraig V. Kissinger, Beth Goddu, Lois Goepfert, Neil M. Rofsky, Warren J. Manning, Reza Nezafat

Feasibility of Acoustically Triggered CINE Imaging for Global Cardiac Function Assessment Using an MR- Stethoscope...... 4515 Tobias Frauenrath, Fabian Hezel, Jane F. Utting, Gabriele A. Krombach, Thoralf Niendorf

Adaptive Heart Rate Prediction for Black-Blood Systolic Imaging ...... 4516 Julien Oster, Brice Fernandez, Maélène Lohezic, Damien Mandry, Pierre-André Vuissoz, Olivier Pietquin, Jacques Felblinger,

Free-Breathing Real Time Cardiac Function Assessment in Patients: A 3T Versus 1.5T Study...... 4517 Jean-Noel Hyacinthe, Magalie Vialon, Alexandru Cernicanu, Chirine Parsei, Sven Zuehlsdorff, Pierre Croisille, Pierre-Frederic Keller, Dominique Didier, Jean-Paul Vallee

Cardiac Cine: Advances at 7T ...... 4518 Lance J. DelaBarre, Peter Weale, Carl j. Snyder, Pierre-Francois van de Moortele, Greg Metzger, Sven Zuehlsdorff, Sonia Nielles- Vallespin, Pat Bolan, Eddie J. Auerbach, Kamil Ugurbil, Renate Jerecic, John Thomas Vaughan

Whole Heart Flow Sensitive 4D MRI...... 4519 Alex Frydrychowicz, Philipp Blanke, Max Russe, Jelena Bock, Aurelien F. Stalder, Daniela Föll, Raoul Arnold, Philip Kilner, Michael Markl

Turbulence Mapping Extends the Utility of Phase-Contrast MRI in Mitral Valve Regurgitation ...... 4520 Petter Dyverfeldt, John-Peder E. Kvitting, Gabriella Boano, Carljohan Carlhäll, Andreas Sigfridsson, Ulf Hermansson, Ann F. Bolger, Jan Engvall, Tino Ebbers

Optimized Estimation of Global and Regional Aortic Pulse Wave Velocity ...... 4521 Michael Markl, Wolf Wallis, Stefanie Brendecke, Jan Simon, Alex Frydrychowicz, Cornelius Weiller,Jürgen Hennig, Andreas Harloff

In-Vitro Turbulence Mapping in Prosthetic Heart Valves Using Generalized Phase- Contrast MRI ...... 4522 Petter Dyverfeldt, John-Peder E. Kvitting, Andreas Sigfridsson, Stefan Franzén, Ann F. Bolger, Tino Ebbers

Diffusion Weighted Imaging of Bone Marrow : Comparison of Apparent Diffusion Coefficients of Normal Bone Marrow and Metastatic Bone Disease to Inform the Development of a Protocol Optimised to Metastatic Bone Disease...... 4523 Christina Messiou, Veronica A. Morgan, David J. Collins, Nandita M. DeSouza

Bone Segmentation Algorithm by Using Geometric Features in Magnetic Resonance Imaging ...... 4524 June-Goo Lee, Youngkyu Song, Jee-Hyun Cho, Jong Baek Seo, Jong Hyo Kim, Gyunggoo Cho

Solid-State 1H and 31P MRI Detects Changes in Bone Mineralization and Water Content in OVX Rat Bone in Response to Treatment with Alendronate ...... 4525 Sailaja Anumula, Debra Horng, Suzanne L. Wehrli, Jeremy Magland, Felix W. Wehrli

Comparative Analysis of Capability for Bone Metastases Assessment Among Whole-Body Diffusion-Weighted Imaging, Whole-Body MR Imaging Without and with Diffusion-Weighted Imaging, Bone Scan and Whole-Body FDG-PET/CT in Non-Small Cell Lung Cancer Patients ...... 4526 Keiko Matsumoto, Yoshiharu Ohno, Hisanobu Koyama, Munenobu Nogami, Daisuke Takenaka, Yumiko Onishi, Nobukazu Aoyama, Hideaki Kawamitsu, Kazuro Sugimura

Internal Gradient Evaluation in Spongy Bone as a Potential NMR Parameter to Detect Osteoporosis Disease ...... 4527 Silvia De Santis, Mauro Rebuzzi, Giulia Di Pietro, Bruno Maraviglia, Silvia Capuani

High-Resolution 3D UTE Imaging of Cortical Bone ...... 4528 Ahi Sema Issever, Peder Larson, Sharmila Majumdar, Dan Vigneron, Roland Krug, Wang Chunsheng, Thomas Link

In Vivo Measurement of Cortical Bone Bulk Susceptibility with Ultrashort TE (UTE) Pulse Sequences...... 4529 Jing-Tzyh Alan Chiang, Jiang Du, Atsushi Takahashi, Robert F. Mattrey, Graeme Bydder

Quantitative Imaging of Cortical Bone Using Ultrashort TE (UTE) Sequences...... 4530 Jiang Du, Won Bae, Michael Carl, Mark Bydder, Atsushi M. Takahashi, Reni Biswas, Christine B. Chung, Graeme M. Bydder

Muscle Intracellular Free [Mg2+] Assessed by 31P MRS in Patients with Chronic Intestinal Failure on Long-Term Home Parenteral Nutrition...... 4531 Loris Pironi, Emil Malucelli, Maria Cristina Guidetti, Giovanna Farruggia, Bruno Barbiroli, Stefano Iotti

BOLD Response of Different Muscles to Ischemic Exercise...... 4532 Albrecht I. Schmid, Martin Andreas, Martin Meyerspeer, Ewald Moser, Michael Wolzt

B0 and B1 Correction of High Field T2 Maps of Human Calf Muscle ...... 4533 E. Brian Welch, Mark D. Does, Robin Avison, J. Christopher Gatenby, Malcolm J. Avison, Bruce M. Damon, John C. Gore

Diffusion Tensor Derived Soleus Architecture at Rest and Under Plantarflexion ...... 4534 Usha Sinha, John Hodgson, Shantanu Sinha

Preliminary Study for the Evaluation of the Muscle-Derived Stem Cell Metabolism Using MR Spectroscopy ...... 4535 Song I. Chun, Tae Hyung Kim, Kee Chin Tan, Min Young Choi, Jee Hyun Cho, Kwan Soo Hong, Jung Woog Shin, Ok Chan Jung, Young Il Yang, Chi Woong Mun

Gender-Specific Differences in MR Fiber Tractography of Skeletal Muscles ...... 4536 Yoshikazu Okamoto, Akira Kunimatsu, Tatsuo Kono, Yuka Kujiraoka, Manabu Minami

Muscle Functional Magnetic Resonance Imaging of the Trunk ...... 4537 Noriyuki Tawara, Osamu Nitta, Hironobu Kuruma, Mamoru Niitsu, Atsuto Hoshikawa, Toru Okuwaki, Akiyoshi Itoh

Correlation Between Muscle Magnetization Transfer Ratio and Muscle Strength in Chronic Inflammatory Demyelinating Ployneuropathy...... 4538 Christopher David James Sinclair, Mario A. Miranda, Pedro Cowley, Mary Reilly, John S. Thornton, Tarek A. Yousry,

Improved Fat Suppression Using Multi-Peak Reconstruction for IDEAL Chemical Shift Fat-Water Separation: Application with Fast Spin Echo Imaging ...... 4539 Richard Kijowski, Michael Woods, Kenneth Lee, Kuya Takami, Huanzhou Yu, Ann Shimakawa, Jean Brittain, Scott Reeder,

A Novel Algorithm for Eddy Current Effect Elimination in Three Points Dixon Method ...... 4540 Wu DongMei, Dai YongMing

An Iterative Algorithm Method for T2 Mapping ...... 4541 Weiwei Zhang, Yongchuan Lai, Wenhua Che

Comparison of IDEAL, MultiPeak IDEAL and Fat-Saturated FSE for Imaging of Osteoarthritis (OA) Knee Patients: Initial Clinical Experience...... 4542 Jian Zhao, Radu Bolbos, Ann Shimakawa, Huanzhou Yu, Xiaojuan Li, Sharmila Majumdar, Thomas Link

Temporal Dynamics of Gd-Enhaced T1 Relaxation Time in Deep and Superficial Femoral Articular Cartilage ...... 4543 Zana Hawezi, Carl Johan Tiderius, Jonas Svensson, Leif E. Dahlberg, Eveliina Lammentausta

Reduction of the Magic Angle Effect on Contrast in Magnetization Transfer Imaging of Human Cartilage...... 4544 Weiguo Li, Jun Li, Carol Muehleman, Richard Magin

Accelerated MR Protocol for Cartilage Volume Analysis and "Whole-Organ" Joint Assessment for Osteoarthritis Research Studies...... 4545 Vaishali Soneji Lafita, Richard Kijowski, David Rabago, Michael Woods, Dana Tudorascu, Jessica Klaers, Walter Block

Quantification of 3D Radial Undersampling Artifact to Obtain High Quality Isotropic Resolution (0.36 Mm) for Volumetric Cartilage Assessment...... 4546 Jessica L. Klaers, Ethan K. Brodsky, Walter F. Block

Comparison of Different Quantitative Approaches in T1p Relaxation Time Assessment of the Knee...... 4547 Yukihisa Takayama, Masamitsu Hatakenaka, Ken Okazaki, Takashi Yoshiura, Kei Nishikawa, Tomoyuki Okuaki, Ivan Zimine, Hiroshi Honda

Multicontrast Keyhole Imaging Enables Economy of Acquisition Time Up to 50% in Standard Diagnostic MRI- Knee Protocols...... 4548 Uwe Schuetz, Axel Bornstedt, Volker Rasche

A Fat Saturated Proton Density-Weighted 3D-TSE-Sequence for MRI of the Knee at 3T – First Clinical Results...... 4549 Mike Notohamiprodjo, Annie Horng, Matthias Pietschmann, Wilhelm Horger, Karin A. Herrmann, Jaeseok Park, Jose Garcia del Olmo Raya, Maximilian F. Reiser, Christian Glaser

In Vivo Sodium MRI at 3.0T of Patients with Previous ACL Injury...... 4550 Garry E. Gold, Seungbum Koo, Ernesto Starosweicki, Ronald Watkins, Brian A. Hargreaves, Neal K. Bangerter

In Vivo Follow-Up of Spontaneous Repair of Osteochondral Defects in Rabbit’s Patellar Groove with Quantitative MRI ...... 4551 Piia Kristiina Valonen, Hertta Pulkkinen, Virpi Tiitu, Mikko Lammi, Risto Ojala, Miika Nieminen, Ilkka Kiviranta

Risk Factors of Adhesion After Autologous Chondrocyte Implantation of the Knee ...... 4552 Atsuya Watanabe, Hiroshi Yoshioka, Shuhei Ogino, Tim Bryant, Tom Minas

T2 Relaxation Time of Matrix-Based Autologous Chondrocyte Transplantations (MACT) and Corresponding Healthy Cartilage of the Knee – a Prospective 2-Year Follow-Up Study...... 4553 Annie Horng, Matthias Pietschmann, José Raya, Peter Mueller, Maximilian F. Reiser, Christian Glaser

Changes in T1rho and T2 Relaxation Times of Tibiofemoral Articular Cartilage with Acute Loading ...... 4554 Richard B. Souza, Radu I. Bolbos, Brad T. Wyman, Marie Pierre Hellio, Thomas M. Link, Xiaojuan Li, Sharmila Majumdar

T1p MRI of Human Articular Cartilage at 3T: Topographic Variations and Correlation with Indentation Biomechanical Properties ...... 4555 Won C. Bae, Florian Buck, Reni Biswas, Eric Diaz, Sheronda Statum, Robert L. Sah, Eric Han, Jiang Du, Christine B. Chung

T1p Assessment of Human Cartilage in an Impact Injury Model...... 4556 Daniel Ross Thedens, Sirisha Tadimalla, James A. Martin, Annunziato Amendola, Douglas R. Pedersen

Bone Marrow Edema-Like Lesions and Cartilage Degeneration in Osteoarthritis Using 3T MR T1r Quantification: Longitudinal Assessment...... 4557 Jian Zhao, Radu Bolbos, Sharmila Majumdar, Thomas Link, Xiaojuan Li

Detection of Degenerative Cartilage Disease: Comparison of High Resolution Morphological MR and Quantitative T2 Mapping at 3.0 Tesla ...... 4558 Siegfried Trattnig, Sebastian Apprich, Pavol Szomolanyi, Marius Mayerhoefer, Katja Pinker, Tallal C. Mamisch, Goetz H. Welsch

Articular Cartilage Injury Associate with Acute Rupture of Anterior Cruciate Ligament Injury in the Knee: Assessment with T2 Mapping...... 4559 Atsuya Watanabe, Toshiyuki Okubo, Haruyasu Yamada, Tetsuya Kosaka, Masamichi Takahashi,Atsushi Nozaki, Takayuki Obata, Fumio Osone, Yuichi Wada

Voxel-Wise Assessment of Pathology Evolution in Articular Cartilage Based on Statistically Significant Changes of T2...... 4560 Jose G. Raya, Andreas Biffar, Annie Horng, Olaf Dietrich, Yuko Fukuda, Maximilian Felix Reiser, Christian Glaser

Cartilage T2 of the Patella and Focal Knee Abnormalities at 3T in Relation to Physical Activity in Non Symptomatic Subjects from the Incidence Cohort of the Osteoarthritis Initiative ...... 4561 Christoph Stehling, Hans Liebl, Ben Hyun, Nancy E. Lane, Roland Krug, Thomas M. Link

Combining Static and Dynamic MRI to Explain the Source of Patellofemoral Pain ...... 4562 Frances Theresa Sheehan, Calista M. Harbaugh, Nicole A. Wilson, Abrahm J. Behnam, Timothy J. Brindle, Katharine E. Alter

In Vitro Correlation of MR Parameters Under Loading with Biomechanical Properties of Degenerated Articular Cartilage ...... 4563 Vladimir Juras, Pavol Szomolanyi, Zuzana Majdisova, Irene Sulzbacher, Stefan Gäbler, Siegfried Trattnig

3D High-Resolution In-Vivo Cartilage Deformation of the Knee at 3T After Different Static Exercises Frequently Practised in Craftsman Professions...... 4564 Annie Horng, José Raya, Monika Zscharn, Ulrike Hoehne-Hückstädt, Ingo Hermanns, Ulrich Glitsch,Rolf Ellegast, Maximilian F. Reiser, Christian Glaser

In Vivo Effects of Unloading and Compression on T2 and T1Gd (DGEMRIC) Relaxation Times of Healthy Knee Articular Cartilage at 3 Tesla ...... 4565 Marius E. Mayerhoefer, Goetz Welsch, Tallal C. Mamisch, Siegfried Trattnig

Assessment of Interscanner and Intravendor Variability of T2 Relaxation Times of Cartilage in Human Tibia at 1.5T and 3T...... 4566 Yuko Fukuda, Annie Horng, Jose Raya, Juergen Weber, Reiichi Ishikura, Shozo Hirota, Maximilian F. Reiser, Christian Glaser

Differences in T2 Values of Knee Cartilage Measured with Different Scanners ...... 4567 Eveliina Lammentausta, Juhani Multanen, Miika T. Nieminen

Use of a Dual-Echo Fast-Spin-Echo Sequence for T2 Mapping of Cartilage Within a Clinical Trial...... 4568 Jonathan Karl Riek, Edward A. Ashton

Long-Term and Short-Term Reproducibility of T2 Relaxation Time in Human Knee Cartilage...... 4569 Eveliina Lammentausta, Ilkka Hannila, Osmo Tervonen, Miika T. Nieminen

Ultra-Short TE-Enhanced T2 Mapping of Cartilage...... 4570 Ashley Williams, Yongxian Qian, David Bear, Fernando Boada, Constance Chu

Ultrashort Echo Time (UTE) Spin Echo (SE) MR Imaging for the Evaluation of Tmj: Benefits Over Gradient Echo Acquisition...... 4571 Hatice Tuba Sanal, Jiang Du, Atsushi Takahashi, Sheronda Statum, Richard Znamirowski, Graeme M. Bydder, Christine B. Chung

Ultrashort TE Imaging with Rescaled Digital Subtraction (UTE RDS) ...... 4572 Jiang Du, Christine B. Chung, Graeme M. Bydder

3T MR Imaging of the TMJ Using UTE Sequence in Volunteers...... 4573 Hatice Tuba Sanal, Jiang Du, Atsushi Takahashi, Sheronda Statum, Richard Znamirowski, Graeme M. Bydder, Christine B. Chung

Intra-Articular Hyaluronic Acid Treatment of Knee Osteoarthritis in Rats Investigated by Quantitative T2 Measurements ...... 4574 Ping-Huei Tsai, Ming-Chung Chou, Ming-Huang Lin, Chien-Yuan Lin, Hsiao-Wen Chung, Heng-Sheng Lee, Guo-Shu Huang

Double Inversion Recovery (DIR) MR Imaging to Improve a Contrast in Effusion Regions of the Knee ...... 4575 Geon-Ho Jahng, Wook Jin, Hyun Cheol Kim, Dal Mo Yang

Contrast Enhanced Ultrashort Echo Time MRI of the Achilles Enthesis in Normal Volunteers and Psoriatic Arthritis ...... 4576 Richard Hodgson, Andrew Grainger, Laura Coates, Philip O'Connor, Robert Evans, Matthew Robson

Longitudinal Changes in Rheumatoid Arthritis After Rituximab Assessed by Quantitative and Dynamic Contrast Enhanced High-Resolution 3-Tesla-MR Imaging...... 4577 Jan Fritz, Michael Fenchel, Claus D. Claussen, John A. Carrino, Marius S. Horger

Sodium In Vivo Measurement of T1 and T2 Relaxation Times of Articular Cartilage at 7 Tesla...... 4578 Stefan Zbyn, Vladimir Juras, Wolfgang Bogner, Pavol Szomolanyi, Goetz H. Welsch, Michal Bittsansky, Vladimir Mlynarik, Ewald Moser, Siegfried Trattnig

Rapid 3D-Sodium MRI of Knee Joint In-Vivo at 7T...... 4579 Ligong Wang, Yan Wu, Gregory Chang, Niels Oesingmann, Mark E. Schweitzer, Alexej Jerschow,Ravinder R. Regatte

Ultrashort Echo Time Imaging of Cortical Bone at 7 Tesla Field Strength ...... 4580 Roland Krug, Peder E. Larson, Chunsheng Wang, Andrew J. Burghardt, Douglas A.C. Kelley, Thomas M. Link, Xiaoliang Zhang, Dan Vigneron, Sharmila Majumdar

Multiparametric Analysis of Healthy and Diseased Articular Cartilage at 17.6 T and Correlation with Histology...... 4581 Jose G. Raya, Gerd Melkus, Olaf Dietrich, Silvia Adam-Neumair, Elisabeth Mützel, Maimilian F. Reiser, Peter Jakob, Christian Glaser

MRS Characteristics of Creatine Deficiency Syndrome ...... 4582 Ruppen Nalbandian, Hyla Allouche-Arnon, J. M. Gomori, Simon Edvardson, Orly Elpeleg, Rachel Katz-Brull

Intramyocellular Lipids Mobilization in Elderly: Relationships with Physical Activity, Maximal Aerobic Capacity and Insulin Sensitivity...... 4583 David M. Rouffet, Rachida Fissoune, Christophe Hautier, Dominique Sappey-Marinier, Martine Laville, Danielle Ibarolla, Monique Sothier, Marie-France Monnet, Michel Ovize, Marc Bonnefoy, Chris Boesch, Emmanuelle Canet-Soulas

Interrogation of Short T2 Components in Sclerotic Bone Metastases with Ultra Short TE MRI ...... 4584 Christina Messiou, David J. Collins, Matthew D. Robson, Veronica A. Morgan, Nandita M. DeSouza

Computed Diffusion Weighted Imaging (CDWI) for Improving Imaging Contrast...... 4585 Matthew Blackledge, Ben Wilton, Christina Messiou, Dow-Mu Koh, Matin O. Leach, David J. Collins

Parallel RF Transmission in Body MRI for Reduced Dielectric Shading, Improved B1 Homogeneity and Accelerated Imaging at 3.0T: Initial Clinical Experience in 40 Patients Using MultiTransmit...... 4586 Winfried A. Willinek, Juergen Gieseke, Guido Kukuk, Michael Nelles, Roy König, Magnus Andersson, Daniel Thomas, Nushin Morakkabati-Spitz, Romhild Hoogeveen, Christiane K. Kuhl, Hans H. Schild

Irregular Respiratory Motion Correction in 3D T2w-TSE (PACE) Liver Imaging...... 4587 Sang-Young Zho, Jaeseok Park, Dong-Hyun Kim,

VIBE with Projections Onto Convex Sets (POCS) for Abdominal Imaging ...... 4588 Agus Priatna, Eric Hatfield, Samuel Chang, Wilhelm Horger, Stephan Kannengiesser, Vamsi Narra

Pediatric Abdominal Navigated T1-Weighted MRI...... 4589 Shreyas S. Vasanawala, Daniel Gene Church, Yuji Iwadate, Robert Herfkens, Brian Andrew Hargreaves, Anja C. Brau

Intraindividual Comparison of Gadobenate Dimeglumine (MultiHance®) and Ferucarbotran (Resovist®) Enhanced MR Imaging of Hypervascular Liver Lesions...... 4590 Guenther Schneider, Wolfgang Loytved, Luigi Grazioli, Richard Semelka, Gianni Morana, Miles Andrew Kirchin, Arno Buecker, Peter Fries

Use of Iron Sensitive T2 MR Imaging as a Novel Method to Diagnose Hepatocellular Carcinoma...... 4591 Andrew Dean Hardie, Peter Romano

Can Gadolinium-Enhanced MRI Be Used for the Grading of Liver Fibrosis and Acute Hepatitis? ...... 4592 Thomas C. Lauenstein, Khalil Salman, Puneet Sharma, Roger Moreira, Diego R. Martin

Utility of Multiple-Echo Data Image Combination Sequence for SPIO-Enhanced T2-Weighted MR Imaging of Liver MRI at 3.0 T System ...... 4593 Ji Soo Choi, Myeong-Jin Kim, Joo Hee Kim, Jin-Young Choi, Yong Eun Chung

Determination of Optimal Liver-Lesion Contrast in LOW-TIDE B-SSFP Imaging...... 4594 Neville Dali Gai, Lawrence Yao

VIBE with Reversed Asymmetric Echo for Liver Imaging ...... 4595 Agus Priatna, Eric Hatfield, Samuel Chang, Wilhelm Horger, Stephan Kannengiesser, Vamsi Narra

Reduction in Artifacts in the Liver at 3T Using a 3D T2-Weighted Variable Flip-Angle Sequence (SPACE)...... 4596 Andrew Brian Rosenkrantz, Jignesh M. Patel, James S. Babb, Pipps Storey, Elizabeth M. Hecht

Hepatic MR Imaging with 3D Gradient Echo: Linear Cartesian K-Space Ordering with Partial Scan Along Both Slice and Phase Direction...... 4597 Kyung Ah Kim, Myeong-Jin Kim, Gwenael Herigault, Young Eun Chung

SPACE Vs. 3D TSE MRCP at 1.5T MRI with Regard to Difference of Echo Spacing...... 4598 Satoru Morita, Eiko Ueno, Ai Masukawa, Kazufumi Suzuki, Haruhiko Machida, Mikihiko Fujimura,Shinya Kojima, Masami Hirata, Takahiro Ohnishi, Kazuhiro Kitajima, Yasushi Kaji

Determination of Optimal Fat Suppression in LOW-TIDE B-SSFP Imaging Using Eigenvalue Analysis...... 4599 Neville Dali Gai, Lawrence Yao

Fatty Acid Composition of Subcutaneous Fat and Bone Marrow in Human Calf Is Affected by Diet and Exercise: an 1H-MRSI Study at 4T...... 4600 Min-Hui Cui, Jong Hee Hwang, Vlad Tomuta, CJ Segal-Isaacson, Daniel T. Stein

Estimation of Liver Iron Content with Spin-Echo Vs. Gradient-Echo Sequences ...... 4601 Arthur Peter Wunderlich, Holger Cario, Mathias Schmid, Markus Juchems

Location Matched Histological Validation of MRI Parameters Relating to Mural Crohn’s Disease Activity...... 4602 Shonit Punwani, Manuel Rodriguez-Justo, Enrico De Vita, Alan Bainbridge, Stuart Bloom, Steve Halligan, Stuart Taylor

Correlation Between Colonic Mural Apparent Diffusion Coefficient and Clinical/ Biochemical Markers of Inflammation in Acute Colitis...... 4603 Shonit Punwani, Rehana Hafeez, Doug Pendse, Alan Bainbridge, Paul Boulos, Steve Halligan, Stuart Taylor

Staging of Gastric Cancer: A Comparative Study with 64-MDCT and 1.5 T MRI...... 4604 Michele Anzidei, Alessandro Napoli, Beatrice Cavallo Marincola, Fulvio Zaccagna, Pier Luigi Di Paolo, Daniel Geiger, Chiara Zini, Carlo Catalano, Roberto Passariello

Characterization of the Effects of Different Classes of Anesthesia on Gut Motility in the Rat Small Intestine Using Dynamic MRI...... 4605 Amit Ailiani, Thomas Neuberger, Gino Banco, James Brasseur, Nadine Smith, Andrew Webb

Prospective Evaluation of the Value of Secretin in Magnetic Resonance Cholangiopancreaticography in Patients with Suspected Chronic Pancreatitis...... 4606 Johannes T. Heverhagen, Eric Schlaudraff, Klaus J. Klose

MR Cholangiography in Patients with Biliary Complications After Liver Transplantation: Which Sequence Enables Diagnosis and Differentiation Best?...... 4607 Sonja Kinner, Alexander Dechêne, Susanne C. Ladd, Thomas Zöpf, Guido Gerken, Gerald Antoch, Michael Forsting, Thomas C. Lauenstein

Magnetic Resonance Cholangio-Pancreatography (MRCP) of Post-Transplant Ischaemic-Type Biliary Lesion ITBL: Which Is the Best Imaging Sequence? ...... 4608 Andreas Helck, Christoph Johannes Zech, Helmut Diepolder, Wieland Sommer, Maximilian F. Reiser, Christian Glaser, Karin A. Herrmann

Breath-Held 3D Steady State Free Precession MRCP: Preliminary Experience and Comparison with Respiratory- Triggered 3D FRFSE ...... 4609 Christine U. Lee, James F. Glockner

High-Resolution Contrast-Enhanced MR Angiography for the Assessment of Vascular Complications of Pancreas Transplantation: 1.5 T Versus 3T...... 4610 Ahmed Mohamed Housseini, Patrick T. Norton, Ismaeel Mohammad Maged, Ehab Ahmed Abdel-Gawad, Timothy M. Schmitt, Kenneth L. Brayman, Hugo Bonatti, Timothy L. Pruett, Thomas E. Huerta, Klaus D. Hagspiel

Evaluation of Low and High B-Values for the Differentiation Between Pancreatic Carcinoma and Chronic Pancreatitis Using Diffusion-Weighted Imaging...... 4611 Miriam Klauss, Andreas Lemke, Katharina Grünberg, Moritz N. Wente, Hans-Ulrich Kauczor, Stefan Delorme, Lars Grenacher, Bram Stieltjes

Diagnosis of Chronic Pancreatitis with Secretin-Enhanced Diffusion-Weighted MR Imaging ...... 4612 Fatih M. Akisik, Kumaresan Sandrasegaran, Stuart Sherman, Chen Lin, Alex M. Aisen

Autoimmune Pancreatitis: MRI Pattern Including Manganese Enhancement ...... 4613 Sebastian Feuerlein, Andrik J. Aschoff, Markus S. Juchems, Hans-Juergen Brambs, Andrea S. Ernst

Optimization of Fat Suppression for 3.0T DWIBS...... 4614 Tomohiko Horie, Tesuo Ogino, Isao Muro, Taro Takahara, Hisamoto Moriguchi, Yutaka Imai,Kagayaki Kuroda, Marc Van Cauteren

Diffusion-Weighted MR Imaging for the Diagnosis of Intra-Abdominal or Anal Fistula ...... 4615 Masatoshi Hori, Aytekin Oto, Sarah Orrin, Kenji Suzuki, Richard L. Baron

The Evaluation of Diffusion Weighted MR Imaging for Perianal Fistulas...... 4616 Takeshi Yoshizako, Akihiko Wada, Megumi Nakamura, Ai Kobayashi, Koji Uchida, Shinji Hara, Akihiko Matumura, Shirou Ozaki, Hajime Kitagaki

Focal Hepatic Lesion Detection and Discrimination of Benign Lesions and Malignant Lesions: T2-Weighted Imaging Versus Diffusion-Weighted Imaging...... 4617 Dal Mo Yang, Hyun Cheol Kim, Geon-Ho Jahng, Wook Jin

Pancreatic Adenocarcinoma Enhancement Correlates with Histological Differentiation...... 4618 Thomas C. Lauenstein, Bobby Kalb, Juan Sarmiento, Khalil Salman, Volkan Adsay, Diego R. Martin

Small (≤ 2 Cm) Enhancing Lesions Seen Only During the Hepatic Arterial Phase: Evaluation with Gadobenate Dimeglumine (Gd-BOPTA) Enhanced MR Imaging During the Hepatobiliary Phase...... 4619 Michele Di Martino, Daniele Marin, Antonino Guerrisi, Gianmaria De Filippis, Francesca Galati,Carlo Catalano, Roberto Passariello

Hepatocellular Carcinoma in Liver Transplantation Candidates: Intraindividual Comparison of Gadobenate Dimeglumine (Gd-BOPTA) Enhanced MR Imaging and Multiphasic 64-Slice CT ...... 4620 Michele Di Martino, Daniele Marin, Antonino Guerrisi, Gianmaria De Filippis, Daniele Geiger, Carlo Catalano, Roberto Passariello

MRI Correlates of Intratumoral Tissue Types Within Colorectal Liver Metastases: A High Resolution Fresh Ex- Vivo Radiologic Pathologic Correlation Study ...... 4621 Laurent Milot, Maha Guindi, Steven Gallinger, Carol Anne Moulton, Kristy Brock, Laura Dawson, Masoom A. Haider

A T2 Magnetic Resonance Imaging Study of Pancreatic Iron Overload in Thalassemia Major, Thalassemia Intermedia and Thalasso-Drepanocytosis ...... 4622 Gennaro Restaino, Massimiliano Missere, Matteo Ciuffreda, Eleonora Cucci, Alessia Pepe, Giuseppina Sallustio

Metabolic Characterization of Primary Human Colorectal Cancers Using High Resolution Magic Angle Spinning 1H Magnetic Resonance Spectroscopy...... 4623 Martial Piotto, François-Marie Moussallieh, Baudouin Dillmann, Alessio Imperiale, Agnes Neuville, Cecile Brigand, Jean-Pierre Bellocq, Karim Elbayed, Izzie Namer

Detection and Quantification of D-Glucuronic Acid (GlcUA) in Human Bile by Using 1H MRS...... 4624 Tedros Bezabeh, Omkar B. Ijare, Nils Albiin, Urban Arnelo, Bo Lindberg, Ian CP Smith

Solid State 13C-NMR Analysis of Human Gall Bladder Stones ...... 4625 K Jayalakshmi, Kanchan Sonkar, Anu Behari, V. K. Kapoor, Neeraj Sinha

Quantitative Proton MR Spectroscopy as a Biomarker of Tumor Necrosis in the Rabbit VX2 Liver Tumor ...... 4626 Ihab R. Kamel, Manon Buijs, Josephina Vossen, li Pan, Nouha Salibi, Eleni Liapi, Christine Lorenz, Jean-Francois H. Geschwind

Prolonged Signal Decay in the Ablated Area After Radiofrequency Ablation in the Ferucarbotran-Administered Liver: A Basic Experimental Study for the Visualization of Ablative Margins in a Rabbit Model...... 4627 Kensaku Mori, Masayuki Yamaguchi, Hirofumi Fujii, Ryutaro Nakagami, Toshihiro Furuta, Manabu Minami

Non-Invasive and Quantitative Evaluation of Hepatic Fat Accumulation in Ob/ob Mice...... 4628 Hyeonseung Lee, Quan-yu Cai, Chulhyun Lee, Ki-Nam Min, Jong Kook Park, Kyeong-Hoon Jeong, Kwan Soo Hong

Quantitative in Vivo Assessment of Hepatic Lipid Using High-Speed T2-Corrected Multi-Echo Spectroscopy...... 4629 Puneet Sharma, Nashiely Pineda, Miriam Vos, Qin Xu, Xiaoping Hu, Diego Martin

Balanced Steady-State Free Precession Abdominal Imaging Using Two-Point Dixon Fat/Water Decomposition ...... 4630 Ersin Bayram, Vijay Nimbargi, Ramesh Venkatesan, Zachary Slavens, Sabina Prato, Manojkumar Saranathan, Lloyd Estkowski, Anthony Vu

Hepatic Vascular Flow Measurements by Phase Contrast MRI and Doppler Echography: A Comparative and Reproductibility Study...... 4631 Thierry Yzet, Roger Bouzerar, Jean-Dominique Allart, Fabien Demuynck, Brice Robert, Cécile Legallais, Marc-Etienne Meyer, Hervé Deramond, Olivier Balédent

MR-Imaging Characteristics and Post-Therapeutic Morphologic Changes in Liver Metastases from Neuroendocrine Tumors...... 4632 Wieland H. Sommer, Christoph J. Zech, Andreas Helck, Maximilian F. Reiser, Christine Schmid-Tannwald, Karin A. Herrmann

Chemoembolization Follow-Up of Hepatocellular Carcinoma with MRI: Utility of Evaluating Enhancement Features on a 1 Month Follow-Up in Predicting Residual Disease After Therapy...... 4633 Bobby Kalb, Diego R. Martin, Puneet Sharma, Abbas Chamsuddin

Effect of Hepatic Iron Deposition on DWI Measurements in Liver Cirrhosis ...... 4634 Hersh Chandarana, Kinh Gian Do, Ely Felker, Cristina Hajdu, Jens Jensen, Bachir Taouli

Quantitative Analysis for Diffusion-Weighted and Superparamagnetic Iron Oxide Enhanced Magnetic Resonance Imaging in Patients with Chronic Hepatitis C: Correlation with Pathologic Fibrosis and Inflammatory Scores and Clinical Severity...... 4635 Kiminori Fujimoto, Tatsuyuki Tonan, Shuji Nagata, Sanae Azuma, Osamu Nakashima, Masayoshi Kage, Takumi Kawaguchi, Naofumi Hayabuchi, Koji Okuda, Takeshi Johkoh

Hepatocellular Carcinoma (HCC) with Portal Venous Tumor Thrombosis (PVTT) Response to Yttrium-90 Radioembolizaion Evaluated by Functional MRI ...... 4636 Yi Wang, Robert J. Mccarthy, Paul Nikolaidis, Vahid Yaghmai, Laura Merrick, Andrew Larson, Reed Omary, Robert Lewandowski, Riad Salem, Frank H. Miller

Detection of Hepatocellular Carcinoma in Pre-Liver Transplant Patients: Diagnostic Performance of DWI Compared to Gadolinium-Enhanced Imaging ...... 4637 Mi-Suk Park, Jignesh Patel, Sooah Kim, Kinh Gian Do, Leonid Drozhinin, Lorenzo Mannelli, Bachir Taouli

Whole Body MRI for Tumor Staging in Patients with Renal Cell Carcinoma ...... 4638 Bernd B. Frericks, Bernhard C. Meyer, Alexander Huppertz, Karl-Juergen Wolf, Frank K. Wacker

Multi-Station Multi-Sequence Approach for Whole-Body Diffusion-Weighted Imaging...... 4639 Yeji Han, Sandra Huff, Jürgen Hennig, Ute Ludwig

A Combined Whole Body Diffusion- And Continous Table Movement STIRProtocol for the Assessment of Fever of Unknown Origin (FUO): First Results ...... 4640 Sabine Weckbach, Henrik J. Michaely, Dietmar J. Dinter, Stefan O. Schoenberg

Whole-Body MRI at 1.5 and 3 Tesla Compared to FDG-PET-CT for the Detection of Tumor Recurrence in Patients with Colorectal Cancer ...... 4641 Gerwin P. Schmidt, Andrea Baur-Melnyk, Alexander Haug, Becker Chistoph, Reinhold Tiling,Maximilian F. Reiser, Karin Herrmann

Early Assessing Tumor Response to Transarterial Chemoembolization by Diffusion-Weighted Imaging: Selection of the Optimal B Factor ...... 4642 Zhaoxia Jiang, Weijun Peng

Accuracy of Diffusion-Weighted Imaging for the Detection of Viable Tumor After Local Treatment of Hepatocellular Carcinoma in Cirrhotic Patients ...... 4643 Sung Eun Rha, Young Joon Lee, Soon Nam Oh, Seung Eun Jung, You Sung Kim, Jae Young Byun

Diagnostic Value of Normalized Liver ADC Using the Spleen as a Reference for the Diagnosis of Cirrhosis...... 4644 Kinh Gian Do, Hersh Chandarana, Cristina Hajdu, Ruliang Xu, Bachir Taouli

Apparent Diffusion Coefficient of Hepatocellular Carcinoma...... 4645 Paul Thomas Stanton, Fred Kelcz

Echo Planar Diffusion-Weighted MRI of the Abdomen and Pelvis: Comparison of Free-Breathing Monopolar and Bipolar Spin-Echo Sequences in Image Quality and Geometric Distortions...... 4646 Stavroula Kyriazi, Veronica A. Morgan, David J. Collins, Nandita M. DeSouza

Reproducibility of ADC Measurements of Abdominal Organs at 1.5T and 3T...... 4647 Andrew Rosenkrantz, Marcel Oei, Hersh Chandarana, Bachir Taouli

Respiratory Motion Artefact Reduction on Abdominal DWI: Simultaneous Use of Dual Bipolar Diffusion Gradient and Navigator Slice Tracking...... 4648 Tetsuo Ogino, Tomohiko Horie, Isao Muro, Taro Takahara, Marc Van Cauteren

Pitfalls in Abdominal Diffusion-Weighted Imaging – How Specific Is Restricted Water Diffusion for Malignancy? ...... 4649 Sebastian Feuerlein, Sandra Pauls, Markus S. Juchems, Hans-Juergen Brambs, Andrea S. Ernst

Gd-EOB-DTPA Enhanced MR Imaging Findings of Non-Diffuse Fatty Change of the Liver ...... 4650 Atsushi Higaki, Akira Yamamoto, Tsutomu Tamada, Hiroki Higashi, Tomohiro Sato, Akihiko kanki, Katsuyoshi Ito

High Resolution Double Arterial Phase Hepatic MR Imaging Using Adaptive 2D Centric View Ordering: Initial Clinical Experience...... 4651 Russell N. Low, Ersin Bayram, Neeraj Panchal, Lloyd Estowski

Quintuple Arterial Phase Gd-EOB-DTPA Enhanced Dynamic MR Imaging with Interleaved Stochastic Trajectories for Hepatocellular Carcinoma ...... 4652 Satoru Kitano, Nagaaki Marugami, Junko Takahama, Aya Hashimoto, Toshiaki Taoka, Shinji Hirohashi, Kimihiko Kichikawa

Gadolinium-Enhanced Multi-Phasic MR Imaging of the Liver and Pancreas at 3.0 Tesla: Qualitative and Quantitative Comparison with 1.5 Tesla ...... 4653 Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Yasuhiro Nakaya, Atsushi Nakamoto, Mitsuaki Tatsumi, Kaname Tomoda, Hironobu Nakamura

MR Cholangiography with Gd-EOB-DTPA: Biliary Enhancement Dynamics in Clinical Patients ...... 4654 Hiromitsu Onishi, Tonsok Kim, Masatoshi Hori, Takamichi Murakami, Mitsuaki Tatsumi, Yasuhiro Nakaya, Atsushi Nakamoto, Takahiro Tsuboyama, Kaname Tomoda, Hironobu Nakamura

Kinetic Analysis of Gd-EOB Uptake by Hepatocytes with Gd-EOB-Enhanced Dynamic MR Imaging ...... 4655 Hiromitsu Onishi, Tonsok Kim, Masatoshi Hori, Takamichi Murakami, Takahiro Tsuboyama, Mitsuaki Tatsumi, Atsushi Nakamoto, Yasuhiro Nakaya, Kaname Tomoda, Hironobu Nakamura

Contrast-Enhanced MR Cholangiography with Gd-EOB-DTPA: Visualization of the Biliary Ducts in Comparison with HASTE MR Cholangiography ...... 4656 Yoshihiko Fukukura, Takuro Kamiyama, Koji Takumi, Toshikazu Shindo, Yuichi Kumagai, Masayuki Nakajo

Comparison of Hepatic Enhancement and Tumor-To-Liver Contrast at Gd-EOBDTPA Enhanced MR Imaging Between 1.5 T and 3.0 T...... 4657 Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Yasuhiro Nakaya, Atsushi Nakamoto, Takahiro Tsuboyama, Mitsuaki Tatsumi, Kaname Tomoda, Hironobu Nakamura

The Usefulness of Gadoxetic Acid (Gd-EOB-DTPA)-Enhanced MRI for Follow-Up Study in Patients of Malignant Hepatic Tumors Performed RF Ablation: Correlated with Four-Phase MDCT ...... 4658 Jung-Hee Yoon, Eun-Joo Lee, Seong-Sook Cha, Sang-Suk Han, Suk-Jin Choi, Oh-Whan Park, Yeon-Jae Lee, Seong-Jae Park

Optimization of Primovist-Enhanced MR Imaging Protocol...... 4659 Akihiro Tanimoto, Akihisa Ueno, Shigeo Okuda

Dynamic Contrast-Enhanced MR Imaging of the Abdominal Solid Organ and the Major Vessel: Comparison of the Enhancement Effect Between Gd-EOB-DTPA and Gd-DTPA ...... 4660 Tsutomu Tamada, Katsuyoshi Ito, Hiroki Higashi, Takenori Yamashita, Teruki Sone, Shigeru Watanabe, Daigo Tanimoto, Akihiko Kanki, Akiyuki Torigoe

T2-Weighted MR Imaging of the Liver: Evaluation of the Effect in Signal Intensity After Gd-EOB-DTPA Enhancement...... 4661 Tsutomu Tamada, Katsuyoshi Ito, Hiroki Higashi, Teruki Sone, Akira Yamamoto, Naoto Egashira, Tomohiro Sato, Fuyuki Tanaka, Atsushi Higaki

Signal Changes in Liver, Spleen and Bone Marrow at SPIO (Ferucarbotran) Enhanced MR Imaging in Patients with Liver Cirrhosis, Hepatitis and Normal Liver ...... 4662 Akiyuki Torigoe, Akira Yamamoto, Takenori Yamashita, Makito Kobatake, Shigeru Watanabe, Daigo Tanimoto, Akihiko kanki, Katsuyoshi Ito

Dynamic Contrast-Enhanced MRI in Evaluating the Intranodular Hemodynamic Characteristics of Focal Hepatic Nodules in an Experimental Rat Model...... 4663 Dawei Yang, Cheng Zhou, Zhenghan Yang, Yue Guo

Characterization of Focal Liver Lesions Using Ferucarbotran-Enhanced Liver MRI: Efficacy of Percentage Signal Intensity Loss for Detecting Nodules Within Diffuse Liver Disease ...... 4664 Chen-Te Chou, Ran-Chou Chen,

Assessment of Transporters of Gd-EOB-DTPA in Various Hepatocellular Nodules During Hepatocarcinogenesis Induced in Rat Livers...... 4665 Natsuko Tsuda, Osamu Matsui

Multi-Site Transferability of Image Analysis Methods for Assessing Visceral Adipose Tissue by MRI...... 4666 Vincenzo Positano, Francesca Forestieri, Roberta Petz, Emma Di Gregorio, Maria Filomena Santarelli, Luigi Landini, Amalia Gastaldelli

A Semi-Empirical Predictor for Visceral Fat Fraction from 3D Dual Echo Dixon Technique...... 4667 Kajoli Banerjee Krishnan, Uday Patil, Rakesh Mullick, Patrice Hervo

FSE Triple-Echo Dixon (FTED) Preliminary Experience with a Novel Sequence for Fat Suppressed T2-Weighted Abdominal MR Imaging...... 4668 Russell Norman Low, Jingfei Ma, Neeraj Panchal

Simultaneous R2 and Fat Fraction Determination of the Liver with Modulus and Real Multiple Gradient-Echo MRI ...... 4669 Naoki Ohno, Tosiaki Miyati, Eri Ono, Harumasa Kasai, Masaki Hara, Yuta Shibamoto, Makoto Kawano, Miyuki Asahi, Tomoyuki Okuaki, Tomoyuki Yamamoto

MR Elastography for the Early Detection of Steatohepatitis in the Rat with Fatty Liver...... 4670 Najat Salameh, Benoît Larrat, Jorge Abarca-Quinones, Stéphane Pallu, Mylène Dorvillius, Isabelle Leclercq, Mathias Fink, Ralph Sinkus, Bernard E. Van Beers

Assessment of Hepatic Steatosis, Iron Overload and Combined Disease with 3 Tesla MR Three-Dimensional T1w Two-Point Dixon Imaging: In-Vivo Validation and In-Vitro Calibration of Decomposition Technique...... 4671 Daniel T. Boll, Grace M. Redmon, Stephen I. Zink, Daniele Marin, Elmar M. Merkle

Estimation of Fat Fraction Considering T2 Decay in Liver After SPIO Injection ...... 4672 Tomoyuki Okuaki, Kengo Yoshimitsu, Ivan Zimine, Shutaro Saiki, Marc Van Cauteren, Toshiaki Miyati

Single Breath Hold Multi-Echo Liver Fat Quantitation ...... 4673 Marko K. Ivancevic, Jouke Smink, Hero K. Hussain, Thomas L. Chenevert

Quantification of Iron Deposition in Chronic Liver Disease ...... 4674 Andrew Dean Hardie

Evaluation of the Liver Iron Concentration (LIC) at 3T in Comparison to 1.5T in Patients with Thalassemia and Falciforme...... 4675 Thomas Martin Doring, Flavia P. Junqueira, G M. Cunha, Antonio C. Coutinho Jr. , Antonio Adilton Carneiro, Marcio Bernardes, J L. Fernandes, Romeu Cortes Domingues

SPIO-Enhanced MR Evaluation of Regional Hepatic Blood Flow...... 4676 Takeshi Yoshikawa, Shohei Miyazaki, Nobukazu Aoyama, Kenya Murase, Yoshiharu Ohno, Tetsuo Maeda, Hideaki Kawamitsu, Kazuro Sugimura

Getting More Out of 31P MRS of the Human Liver Moving from 1.5T to 3T...... 4677 Ronald Ouwerkerk, Alena Horska, Michael Schär, Susanne Bonekamp, Mariana Lazo, Jeanne M. Clark

Differential Profile of Body Fluid Change in Type II Diabetic Patients and Healthy Volunteer Subjects Following Pioglitazone Treatment...... 4678 Young-Hoon Sung, Chun S. Zuo, Annaswamy Raji, Robert L. Dobbins, Derek J. Nunez, Donald C. Simonson, Rosemond A. Villafuerte, Rebecca J. Hodge, Sam R. Miller, Andrew P. Brown, Perry F. Renshaw, Michael E. Henry

Pilot Investigation of Intramyocellular and Abdominal Lipid Contents by 2D MR Spectroscopy and MRI in Patients with Type2 Diabetes and Impaired Fasting Glucose ...... 4679 Aparna Singhal, Preethi Srikanthan, Neil Wilson, Anthony Sosa, Sendhil Velan, Nagesh Ragavendra, RK S. Rathore, Rakesh K. Gupta, Michael Albert Thomas

Hepatic Phosphorus Metabolite Concentrations of Patients with Type 2 Diabetes Assessed by 31P 3D MRSI ...... 4680 Marek Chmelik, Albrecht Ingo Schmid, Stephan Gruber, Wolfgang Bogner, Julia Szendroedi, Martin Krssak, Siegfried Trattnig, Ewald Moser, Michael Roden,

Estimation of Liver Fat Fraction Using MR Spectroscopy and Multi-Echo MRI : Clinical Evaluation in Diabetic Population...... 4681 Ramkumar Krishnamurthy, Medhavi Jogi, Debra Dees, Raja Muthupillai, Mandeep Bajaj

Nephrogenic Systemic Fibrosis in Liver Disease: a Systematic Review ...... 4682 Sameer M. Mazhar, Masoud Shiehmorteza, Michael S. Middleton, Claude B. Sirlin

Characterization of Renal Masses: Is There a Threshold for Differentiating Noise from True Enhancement on Subtraction Imaging?...... 4683 Samson Wong, Sooah Kim, Nicole Hindman, Daniel Sahlein, Vivian S. Lee

Imaging of Different Subtypes of Solid Renal Tumors ...... 4684 Ewtim Rainer Dabew, Peter Fries, Marcus Katoh, Frank Becker, Arno Bücker, Günther Schneider

Diffusion Weighted MRI in Assessment of Renal Masses...... 4685 Kumaresan Sandrasegaran, Fatih M. Akisik, Chandru P. Sundaram, Magnus P. Rydberg, Chen Lin,Alex M. Aisen

Acute Ureteral Obstruction: Monitoring Treatment by Blood Oxygenation Level-Dependent MRI ...... 4686 Peter Vermathen, Sonia C. Simon-Zoula, Tobias Binser, Thomas M. Kessler, Maria Triantafyllou, Chris Boesch, Urs E. Studer, Harriet C. Thoeny

Evaluation of the Feasibility and Reproducibility of BOLD MRI in Healthy Volunteers Compared to Kidney Transplant Patients – Preliminary Study ...... 4687 Marica Cutajar, Stephen D. Marks, Paul Brogan, Isky Gordon

Development of a Method for Measuring the Dynamics of Oxygen Consumption in the Kidney Using Blood Oxygenation Level-Dependent Magnetic Resonance Imaging ...... 4688 Yoshinori Kusakabe, Yasuyoshi Inoue, Koji Okada, Youichi Yamazaki, Kenya Murase

Evaluation of Intra-Renal Oxygenation in Db/db Mice by BOLD MRI...... 4689 Lu-Ping Li, Sarah Halter, JoAnn Cabray, Pottumarthi V. Prasad

Variability of Renal ADC: Limitations of Monoexponential Model...... 4690 Jeff Lei Zhang, Eric E. Sigmund, Henry Rusinek, Hersh Chandarana, Qun Chen, Pippa Storey, Louisa Bokacheva, Vivian S. Lee

Quantification of Renal Diffusion-Weighted Images Using a Bi-Exponential Model...... 4691 Jeff Lei Zhang, Eric E. Sigmund, Henry Rusinek, Hersh Chandarana, Qun Chen, Pippa Storey, Louisa Bokacheva, Vivian S. Lee

Evaluation of Normal and Dysfunctional Renal Transplants Using DTI ...... 4692 Hersh Chandarana, Vivian S. Lee, David Stoffel, Laura Barisoni-Thomas, Devon G. John, Thomas Diflo, Eric E. Sigmund

Evaluation of Renal Allograft Function Early After Transplantation with Diffusion-Weighted MR Imaging - Initial Experience...... 4693 Ute Eisenberger, Tobias Binser, Chris Boesch, Felix J. Frey, Peter Vermathen, Harriet C. Thoeny

Assessing Native and Transplant Kidneys with Diffusion Weighted MR Imaging: Mean Vs Delta ADC...... 4694 Robert W. Garrett, Karl Vigen, Sean Fain, Garima Agrawal, Thomas Grist, Elizabeth A. Sadowski

DTI of Human Kidney at 3T - Simultaneous and Reliable Determination of Fractional Anisotropy, ADC and Perfusion Fraction...... 4695 Tobias Binser, Harriet C. Thoeny, Chris Boesch, Peter Vermathen

Diffusion-Weighted MR Imaging (DWI) in Adrenal Lesions: Clinical Applications ...... 4696 Yi Wang, Robert J. Mccarthy, Laura Merrick, Paul Nikolaidis, Vahid Yaghmai, Riad Salem, Frank H. Miller

Evaluation of 3.0T MR Diffusion-Weighted Imaging in Renal Malignant Tumor...... 4697 Yu Xiaoduo, Ou Yanghan

Diffusion MR Imaging: ADC Mapping of Malignant and Benign Breast Tumors...... 4698 Sunitha B. Thakur, Nicole Ishill, David D. Dershaw, Jason A. Koutcher, Elizabeth A. Morris

Diffusion Weighted Imaging of the Breast at 3.0T with BLADE-TSE: Initial Experience...... 4699 Chen Lin, Christian Geppert, Alto Stemmer, helmuth Schultze-Haakh, Shadie S. Majidi, Hal Douglas Kipfer

Diffusion Imaging of the Breast - Pearls and Pitfalls Learned During Routine Clinical Use...... 4700 Frederick Kelcz

Validation of a Nonrigid Registration Algorithm for Longitudinal Breast MR Images ...... 4701 Xia Li, Benoit Dawant, E. Brian Welch, A. Bapsi Chakravarthy, Darla Freehardt, Ingrid Mayer, Mark Kelley, Ingrid Meszoely, John Gore, Thomas Yankeelov

Ductal Carcinoma in Situ Diagnosed with Contrast-Enhanced Breast MR Imaging. Can Invasion Be Predicted? ...... 4702 Mariko Goto, Sachiko Yuen, Kei Yamada, Eiichi Konishi, Tsunehiko Nishimura

Clinicopathological Correlation of Residual Breast Cancer Diagnosed by MRI in Patients Receiving Neoadjuvant Chemotherapy with and Without Bevacizumab (Avastin®)...... 4703 Shadfar Bahri, Jeon-Hor Chen, Ke Nie, Rita S. Mehta, Philip M. Carpenter, Soon-Young Kwon, Hon J. Yu, Orhan Nalcioglu, Min- Ying Su

Characterization of Breast Tumors with Functional Imaging: Evaluation with Real-Time Ultrasound Elastography and Diffusion-Weighted MR Imaging with Apparent Diffusion Coefficient (ADC) Value Analysis ...... 4704 Naoto Egashira, Katsuyoshi Ito, Takenori Yamashita, Teruki Sone, Tsutomu Tamada, Akira Yamamoto

MRI Quantitative Changes of Breast Tissue Composition with Short-Term Tamoxifen Treatment in Cancer Patients...... 4705 Abimbola Oluwayemisi Orisamolu, Catherine S. Klifa, Sachiko Anne Suzuki, Juan Nicolas Lessing, Jessica E. Gibbs, Dorota Jakubowski-Wisner, Bonnie N. Joe, Eunsil Shelley Hwang, Nola M. Hylton

Quantitative Measures of Breast Density and Tissue Patterns Using MRI ...... 4706 Catherine Klifa, Julio Carballido-Gamio, Jessica Gibbs, Nola Hylton

Mammographic and MR Density in Dense Breasts: Is There a Correlation?...... 4707 Priya Kumar Sareen, Ava Kwong, Debra M. Ikeda, Catherine Klifa

MR-Based Computer-Aided Breast Density Measurement Compared with Mammographic Measurement...... 4708 Byron A. Feig, Jeon-Hor Chen, Ke Nie, Thomas J. Bakondy, Vashita Dhir, Kenneth Meng, R Oganeseyan, Orhan Nalcioglu, Min- Ying Lydia Su

Exclusion of Skin for Measurement of Fibroglandular Breast Density on 3D MRI...... 4709 Ke Nie, Daniel Chang, Jeon-Hor Chen, Chieh-Chih Hsu, Tzu-Ching Shih, Hoanglong Nguyen, Muqing Lin, Orhan Nalcioglu, Min- Ying Lydia Su

Clinical Assessment of Complex Valued Combinations of Ip- And Op-Data in MR Mammography...... 4710 Karl-Heinz Herrmann, Pascal AT Baltzer, Alexander Rauscher, Hartmut P. Burmeister, Werner A. Kaiser, Jürgen R. Reichenbach

Increasing the Scanning Efficiency of 3D FSE – IDEAL for Volumetric Breast Coverage...... 4711 Ananth J. Madhuranthakam, Ann Shimakawa, Huanzhou Yu, Martin P. Smith, Reed F. Busse, Scott B. Reeder, Neil M. Rofsky, Jean H. Brittain, Charles A. McKenzie

MR Mammography at 7 Tesla: Preliminary Results ...... 4712 Lale Umutlu, Stefan Maderwald, Oliver Kraff, Jens M. Theysohn, Sherko Kuemmel, Elke A. Hauth, Michael Forsting, Gerald Antoch, Mark E. Ladd, Harald H. Quick, Thomas C. Lauenstein

Parallel RF Transmission for Breast MRI at 3.0 Tesla: Preliminary Results...... 4713 Christiane K. Kuhl, Guido Kukuk, Juergen Gieseke, Yvonne Mekes-Rijckaert, Hans H. Schild

Measuring Renal Function During Routine Clinical MR Exams: Is 5 Min Enough?...... 4714 Jeff Lei Zhang, Henry Rusinek, Keyma Prince, Hersh Chandarana, David Stoffel, Louisa Bokacheva, Qun Chen, Pippa Storey, Vivian S. Lee

Characteristics and Reproducibility of the Arterial Input Function (AIF) Derived from Dynamic Contrast- Enhanced Magnetic Resonance Imaging (DCE-MRI) Studies and Its Effect on Renal Functional Parameters ...... 4715 Marica Cutajar, Iosif A. Mendichovszky, Paul S. Tofts, Isky Gordon

Measurement Accuracy of a Gadolinium Enhanced Magnetic Resonance Imaging Technique for the Measurement of Kidney Glomerular Filtration ...... 4716 Khalil Nabeel Salman, Saravanan Kokila Krishnamoorthy, Puneet Sharma, Bobby Kalb, Dana Tudorascu, Diego R. Martin

Blade DCE MRI - Towards Renal Perfusion Measurements with Reduced Motion Artifacts ...... 4717 Florian Lietzmann, Frank Zöllner, Lothar Rudi Schad

Towards Renal Compartment Segmentation Using an Unsupervised Neural Network Approach...... 4718 Frank Gerrit Zöllner, Lothar Rudi Schad

Automatic Estimation of Renal Cortical Thickness Using MRI Perfusion Curves ...... 4719 Luis Meneses, Cristian Tejos, Marcelo Andía, Mario Fava, Pablo Irarrazaval

Effect of Acute Hyperglycemia with Octreotide on Intra-Renal Oxygenation as Estimated by BOLD MRI in Rats ...... 4720 Lu-Ping Li, Joann Carbray, Sarah Halter, Pottumarthi V. Prasad

Monitoring Kidney Viability Before Transplantation by Means of 31P CSI and Oxygenated Hypothermic Perfusion...... 4721 Francois Lazeyras, Leo Buhler, Jean-Paul Vallee, Antonio Nastasi, Raphael Ruttimann, Philippe Morel, Jean-Bernard Buchs

High Intense Myometrial Tumors on T2-Weighted Images: Differentiation with Diffusion-Weighted Imaging and 1H-MR Spectroscopy ...... 4722 Mayumi Takeuchi, Kenji Matsuzaki, Masafumi Harada, Hiromu Nishitani

MR Manifestations of Hyperreactio Luteinalis: Value of Diffusion-Weighted Imaging in the Differentiation from Neoplastic Lesions ...... 4723 Mayumi Takeuchi, Kenji Matsuzaki, Hiromu Nishitani

Combined Use of T2-Weighted and Diffusion-Weighted 3T MR Imaging for Differentiating Uterine Sarcomas from Benign Leiomyomas...... 4724 Tomohiro Namimoto, Kazuo Awai, Takeshi Nakaura, Yumi Yanaga, Tetsuo Saito, Toshinori Hirai, Yasuyuki Yamashita

Diffusion-Weighted (DW) Imaging in Ovarian Cystic Lesions: Value of DW Imaging Compared to T2-Weighted Imaging at 3T MRI...... 4725 Tomohiro Namimoto, Kazuo Awai, Takeshi Nakaura, Yumi Yanaga, Shinichi Nakamura, Tetsuo Saito,Toshinori Hirai, Yasuyuki Yamashita

Susceptibility-Weighted Imaging for the Evaluation of Gynecologic Diseases ...... 4726 Mayumi Takeuchi, Kenji Matsuzaki, Hiromu Nishitani

The Time-Course Effect of Anticholinergic Agents on Intestinal Motion and Uterine Peristalsis: Evaluation on Cine MRI ...... 4727 Sayaka Daido, Asako Nakai, Tomohisa Okada, Toshikazu Kamae, Koji Fujimoto, Isao Ito, Kaori Togashi

Dynamic Contrast-Enhanced MRI of Cervical Tumors During Chemo-Radiation Correlated to Tumor Regression...... 4728 Uulke A. van der Heide, Catalina Arteaga de Castro, Greetje Groenendaal, Cornelis A.T. van den Berg, Ina M. Jurgenliemk- Schulz, Judith M. Roesink

DCE-MRI at 3T in Patients with Advanced Ovarian Cancer Undergoing Neo-Adjuvant Chemotherapy ...... 4729 Andrew Nicholas Priest, Andrew B. Gill, Masako Y. Kataoka, Ilse Joubert, Mary A. McLean, Martin J. Graves, John R. Griffiths, Robin Crawford, Helena Earl, James Brenton, David J. Lomas, Evis Sala

Silibinin Feeding Alters the Metabolic Profile in TRAMP Prostatic Tumors: A 1H-NMR Study ...... 4730 Natalie J. Serkova, Komal Raina, Andrea L. Merz, Rajesh Agarwal

Pre-Clinical Evaluation of Anti-Angiogenic Agent RO0281501 on R3327 AT Prostate Model Using Lactate MRS and DCE-MRI...... 4731 Jadegoud Yaligar, Sunitha B. Thakur, Mihai Coman, Mihaela E. Lupu, Ya Wang, Kenneth Kolinsky, Brian Higgins, Kristen L. Zakian, Jason A. Koutcher,

Comparison Between ADC and QSI-Derived Parameters Mapping and Early Effect of Radiation Therapy in a Rodent Tumour Model ...... 4732 Denis Rommel, Frank Peeters, Jorge Abarca-Quinones, Vincent Gregoire, Thierry Duprez

Proton Diffusion Weighted and Sodium MRI of Growing Intrahepatic and Subcutaneous Hepatocellular Carcinoma ...... 4733 Andriy Babsky, Shenghong Ju, Stacy Bennett, Bharath Atthe, Beena George, Gordon McLennan, Navin Bansal

Vascular Phenotyping of Brain Tumors with MR Microscopy (µMRI) ...... 4734 Arvind P. Pathak, Jiangyang Zhang, Melina Jones

Lesion Enhancement in a Rat Brain Tumor Model: Evaluation of 1 M Gadobutrol Vs Two Conventional Gadolinium Chelates, All Injected at a Dose of 0.1 Mmol/kg at 3T...... 4735 Ulrike Irmgard Attenberger, Val M. Runge, Carney B. Jackson, Shannon S. Baumann, Krista Birkemeier, Henrik J. Michaely, Stefan O. Schoenberg, Maximilian F. Reiser, Bernd J. Wintersperger

Osteoblastic and Angiogenic Reactions in Prostate Cancer Bone Metastasis Models Studied by Macromolecular DCE-MRI and µCT...... 4736 Hagit Dafni, Andrew J. Burghardt, Sharmila Majumdar, Nora M. Navone, Sabrina M. Ronen

A Dual Modality System for Simultaneous Monitoring of a Bi-Functional Optical & MRI Contrast Agent for Cancer Detection ...... 4737 Yuting Lin, Mehmet B. Unlu, Brian Grimmond, Anup Sood, Egidijus E. Uzgiris, Orhan Nalcioglu,Gultekin Gulsen

Lymph Node Volume and Apparent Diffusion Coefficient as a Biomarker for Metastatic Invasion in an Experimental Model...... 4738 Wenche Margrethe Klerkx, Albert Geldof, Fredy Visser, Taro Takahara, Peter Luijten, Peter Heintz, Willem Mali, Wouter Veldhuis

Advantages of Micron-Sized Magnetic Particles for Tracking Dendritic Cells in Preclinical Cancer Vaccine Studies...... 4739 Roja Rohani, Greg Dekaban, Christy Willert, Sonali De Chickera, Paula Foster

MRI/ MRS on Leukemia Development in MLL-AF9 Transgenic Mice...... 4740 Deborah DeRyckere, Margaret E. Macy, Kendra M. Hasebroock, Lori A. Gardner, Paul Jedlicka, Erica L. Bradshaw-Pierce, Andrea L. Merz, Lia Gore, Natalie J. Serkova

MR Characterization of Two Experimental Models of Ovarian Cancer: Metabolite Quantification and Diffusion and Perfusion Assessment...... 4741 Rossella Canese, Maria Elena Pisanu, Alessandro Ricci, Luisa Paris, Carmela Rozera, Massimo Spada, Albino Cesolini, Massimo Venditti, Massimo Giannini, Filippo Belardelli, Egidio Iorio, Franca Podo

The Analysis of Lipid and Macromolecule Signals in HR-MAS Data Reveals Information on the Nature of Cytoplasmic Lipid Droplets...... 4742 Martin Wilson, Greg M. Reynolds, Risto A. Kauppinen, Theo N. Arvanitis, Andrew C. Peet,

NMR Structural Characterization and Inhibition of Colon Cancer Cells by Components of Citrus Aurantium L...... 4743 G K. Jayaprakasha, Jadegoud Yaligar, G A. Nagana Gowda, Bhimanagouda S. Patil

A 1H NMR-Based Metabolomics Study of Cellular Senescence, Quiescence and Transformation ...... 4744 Basetti Madhu, Masako Narita, Masashi Narita, John R. Griffiths

Changes in High Spectral and Spatial Resolution Images of Murine Mammary Tumors Due to the Introduction of Carbogen ...... 4745 Sean Foxley, Marta Zamora, Erica Markiewicz, Gregory Karczmar

Simple, Universal Phantom for Multi-Center Apparent Diffusion Coefficient (ADC) Measurement ...... 4746 Marko K. Ivancevic, Charles R. Meyer, Craig J. Galban, Benjamin A. Hoff, Thomas C. Kwee, Brian D. Ross, Thomas L. Chenevert

Monitoring Therapeutic Response in a Murine Model of Medulloblastoma Treated with a Small Molecule Inhibitor of Hedgehog Signaling...... 4747 Bruno Alicke, Christopher Callahan, Ryan Ybarra, Stephen Gould, Joan Greve

Detection of Early Response to Proteasome Inhibitor Treatment in a Rat Glioma Model with Amide Proton Transfer (APT) Imaging...... 4748 Jinyuan Zhou, De-Xue Fu, Tingting Zhou, Bachchu Lal, John Laterra, Peter van Zijl,

Differential Effects of VEGF-Trap on Benign and Malignant Human Melanoma Xenografts Evaluated by DCE MRI ...... 4749 HuaLei Zhang, Hui Qiao, Fabao Gao, Karthik Raju, Steven Pickup, Xin Li, Jerry Glickson, Rong Zhou

Multi-Parametric MR Imaging for Anti-Angiogenic Tumor Treatment Monitoring – a Preclinical Study ...... 4750 Janine Ring, Stefanie Remmele, Walter Heindel, Thorsten Persigehl, Christoph Bremer

Study of Regression of Breast Tumor in Mice Model Using MRI ...... 4751 Sanjay Annarao, Preeti Singh, Madan Madav Godbole, Raja Roy, C L. Khetrapal

Application of a Biodegradable Macromolecular Contrast Agent in Dynamic Contrast Enhanced MRI to Assess the Efficacy of Indocyanine Green Enhanced Photothermal Cancer Therapy...... 4752 Yi Feng, Eun-Kee Jeong, Lyska Emerson, Zheng-Rong Lu

Combined Macromolecular DCE-MRI and Hyperpolarized 13C MRSI Indicate an Association Between Vascular and Metabolic Effects of Imatinib in a Prostate Cancer Bone Metastasis Model...... 4753 Hagit Dafni, Peder E. Z. Larson, Simon Hu, Robert Bok, Chris Ward, Chunsheng Wang, Lynn DeLosSantos, Xiaoliang Zhang, Daniel B. Vigneron, Sabrina M. Ronen

Quantitative DCE-MRI and Positron Emission Tomography (PET) for Assessment of Treatment Response in a Mouse Xenograft Model of Colorectal Cancer...... 4754 Erica Lynn Bradshaw-Pierce, Kendra M. Hasebroock, Andrea L. Merz, John J. Tentler, S Gail Eckhardt, Natalie J. Serkova

Hemodynamic Response Imaging for the Assessment of Anti-Angiogenic Treatment Response ...... 4755 Yifat Edrei, Eitan Gross, Natalie Corchia, Eli Pikarsky, Shmuel Ben-Sasson, Rinat Abramovitch,

Gemcitabine Uptake in Transplanted and Primary Pancreatic Ductal Adenocarcinoma: A 19F MRS Study ...... 4756 Basetti Madhu, Kenneth P. Olive, Mae A. Goldgraben, David A. Tuveson, John R. Griffiths

Therapeutic Effect of Bleomycin and Doxorubicin on Skin Tumors: Assessment by MRI...... 4757 Moganty Raja Rajeswari, Uma Sharma, N. R. Jagannathan, Ashok Sharma

Is Serial MR Spectroscopy Revealing an Anti-Tumor Effect of Cediranib in Human Glioblastoma? ...... 4758 Heisoog Kim, Ciprian Catana, Eva-Maria Ratai, Wei-Ting Zhang, Priscilla Yeo, Ovidiu Cristian Andronesi, Tracy T. Batchelor, Rakesh K. Jain, A. Gregory Sorensen

Evaluation of Diffusion Parameters as Early Biomarkers of Response to Therapy in High-Grade Gliomas ...... 4759 Inas Khayal, Trey Jalbert, Adam ElKhaled, Susan M. Chang, Soonmee Cha, Sarah J. Nelson,

Clinical Potential of Absolute Concentration of Total Choline in Breast Cancer Patients Using In-Vivo Proton MR Spectroscopy: Assessment of Early Therapeutic Response Following Neo-Adjuvant Chemotherapy...... 4760 Rani Gupta Sah, Uma Sharma, Rajinder Parshad, Naranamangalam R. Jagannathan

Preliminary Experience with 3D DCE-MRI Evaluation of Children Treated for Osteosarcoma with Chemotherapy Plus Bevacizumab...... 4761 Wilburn E. Reddick, Junyu Guo, Qing Ji, John O. Glass, Mary E. McCarville, Najat C. Daw

Prostate DCE-MRI with a 16-Channel Surface Array and Endorectal Coil Using Slice Oversampling and SENSE to Minimize Blood Inflow Effect...... 4762 Marcelino Bernardo, Yuxi Pang, Baris Turkbey, Raphael Alford, Vijay Shah, Ahmed M. Gharib, Peter Choyke

Magnetic Resonance Imaging of the Prostate Using a 32 Channel Vs. an 8 Channel Coil at 3T ...... 4763 Steffen Sammet, Guang Jia, Jiachao Liang, Francisco Aguila, Seongjin Choi, Jun Zhang, Michael Vincent Knopp

Evaluation of STIR-HASTE Whole Body MRI for the Initial Staging of Paediatric Lymphoma: A Correlation with PET/CT...... 4764 Shonit Punwani, Steve Bandula, Vineet Prakash, Alan Bainbridge, Enrico De Vita, Nicola Stevens, Stuart Taylor, Sharon Hain, Stephen Daw, Ananth Shankar, Paul Humphries

Multiparametric Comparison of Magnetic Resonance Spectroscopy and Dynamic Contrast Enhanced Magnetic Resonance Imaging with Surgical Pathology ...... 4765 Daniel Jason Aaron Margolis, Daisy Chien, Ana Gomez, Gerhard Laub, Timothy McClure, Rajakumar Nagarajan, Seong Ra, Albert Thomas, J. Paul Finn, Steven Raman

DCE-MRI Evaluation of the Temporal Evolution of Bevacizumab Induced Anti-Vascular Effects in Colorectal Cancer Liver Metastases...... 4766 James P. O'Connor, Gordon C. Jayson, Alan Jackson, Chris J. Rose, Claire L. Mitchell, Yvonne Watson, Caleb Roberts, Sue Cheung, Giovanni A. Buonaccorsi, Andrew R. Clamp, Jurgees Hasan, Lynn Hope, Karen Davies, Olivia del Puerto, Geoff J. Parker

Accuracy of USPIO-Enhanced MRI for Staging of Rectal Cancer: A Multicenter Study in an Expert an 3 Regional Centers...... 4767 Monique Maas, Geerard L. Beets, Max J. Lahaye, Sanne ME Engelen, Jo PM Dohmen, Godelieve RJ Opdenakker, Doenja MJ Lambregts, Joachim E. Wildberger, Regina GH Beets-Tan

Accuracy of Gadofosveset Enhanced MRI for Predicting Nodal Status in Primary Rectal Cancer ...... 4768 Doenja MJ Lambregts, Geerard L. Beets, Alfons G. Kessels, Max J. Lahaye, Sanne ME Engelen, Monique Maas, Adriaan P. de Bruïne, Jan L. Verwoerd, Tim Leiner, Joachim E. Wildberger, Regina GH Beets-Tan

The Therapy Response Monitoring by DCE-MRI in Primary Liver Cancers...... 4769 David H. Gultekin, William R. Jarnagin, Jason A. Koutcher, Mithat Gonen, Dana Haviland, Leslie H. Blumgart, Michael I. D'Angelica, Yuman Fong, Ronald P. DeMatteo, Nancy E. Kemeny, Lawrence H. Schwartz

Assessment of the Antiangiogenic Therapy of Avastin in an Animal Colon Cancer Model with DCE-MRI and a Biodegradable Macromolecular Contrast Agent...... 4770 Xue-Ming Wu, Rongzuo Xu, Eun-Kee Jeong, James N. Lee, Zheng-Rong Lu

Evaluating Acute Response to the Novel HIF Inhibitor NSC-134754 in an Orthotopic Prostate Tumour Model by MRI ...... 4771 Lauren CJ Baker, Simon Walker-Samuel, Jessica K. Boult, Yann Jamin, Margaret A. Ashcroft, Simon P. Robinson

Elucidating the Relationship Between ADC Measures of Cellularity and [18F]FLTPET Indications of Cellular Proliferation in a Multimodal Imaging Study of Treatment Response...... 4772 Shelby Katherine Wyatt, Kevin Wilson, Tuhin Kumar Sinha, H. Charles Manning, Thomas E. Yankeelov, Robert J. Coffey, John C. Gore,

Dynamic Contrast-Enhanced MR Imaging for Early Detection of Vascular-Permeability Changes Following Combination Therapy with Anti-EGFR Antibody and Irinotecan in Orthotopic Pancreatic Tumor Xenografts: A Pilot Study ...... 4773 Hyunki Kim, Karri Folks, Lingling Guo, James George, Jeffrey Sellers, Donald Buchsbaum, Kurt Zinn

Early Detection of Radiation Response in Non-Hodgkin’s Lymphoma Xenografts...... 4774 Seung -Cheol Lee, Tim Jenkins, Stephen Pickup, Harish Poptani, Edward J. Delikatny, Jerry David Glickson

Multifunctional Microspheres with an Ultrahigh Holmium Load for Imaging and Therapy...... 4775 Wouter Bult, Peter Roland Seevinck, Gerard C. Krijger, Chris J.G. Bakker, Wim E. Hennink, Alfred D. van het Schip, Johannes Frank Nijsen

A Method for MR Imaging of Prostate Cancer Patients in the Radiotherapy Treatment Position Without Loss of Image Quality...... 4776 Scott Hanvey, John Foster, Martin Glegg

Registration of Magnetic Resonance Images of the Prostate Obtained with an Endorectal Coil to Histological Sections ...... 4777 Yousef Mazaheri, Oguz Akin, Amita Shukla-Dave, Daniel Chamudot, Liang Wang, Joanna Grater, Samson W. Fine, Victor Reuter, Jason A. Koutcher, Hedvig Hricak

Evaluation of Vascular and Metabolic Response in a Human Breast Cancer Model Treated with Docetaxel ...... 4778 Line Rørstad Jensen, Else Marie Huuse, Tone Frost Bathen, Pål Erik Goa, Steinar Lundgren, Ingrid Susann Gribbestad

In Vivo and Ex Vivo Choline Metabolite Profiles as Biomarkers for Treatment Response in Locally Advanced Human Breast Cancer...... 4779 Mariann Gjervik Heldahl, Beathe Sitter, Tone Frost Bathen, Maria Dung Cao, Steinar Lundgren,Ingrid Susann Gribbestad

Alteration of Fibroglandular Tissue Volume and Contrast Enhancements Measured by MRI in the Normal Breast of Patients Receiving Neoadjuvant Chemotherapy ...... 4780 Jeon-Hor Chen, H-J Yu, S Bahri, C-C Hsu, F-T Hsu, H-N Shih, M-C Lin, K Nie, O Nalcioglu, MY Su

Multiparametric MRI/MRS and Gene Expression Profiling for Monitoring Docetaxel Effects in MCF7 Xenografts...... 4781 Else Marie Huuse, Line Rørstad Jensen, Pål Erik Goa, Steinar Lundgren, Endre Anderssen, Tone Frost Bathen, Ingrid Susanne Gribbestad

Single-Dose X-Ray Irradiation Changes Significantly Tumor Perfusion, as Measured by In Vivo DCE 1H MRI...... 4782 HyungJoon Cho, Ellen Ackerstaff, Matthew Kaag, Mihai Coman, Jason A. Koutcher

Simultaneous Blood Volume and Vessel Size Imaging Technique for Localized Therapy Response Detection ...... 4783 Stefanie Remmele, Julien Sénégas, Thorsten Persigehl, Christoph Bremer, Janine Ring

Acute Vascular and Non-Vascular Enhanced MRI Measurements Made in C6 Tumour Xenografts Before and After MLN0518, a Potent PDGFRß Inhibitor, Treatment...... 4784 Daniel Philip Bradley, Jennifer Terkelsen, Donna Cvet, Barbara Hibner, Kristine Burke, Matthew D. Silva

Longitudinal Study of 1H MRS of Lactate Upon Treatment in a Non-Hodgkin’s Lymphoma Patient...... 4785 Seung -Cheol Lee, Eric A. Mellon, Harish Poptani, Edward James Delikatny, Jerry David Glickson

Dynamic Contrast Enhancement (DCE) MRI of Parotid Glands After Radiotherapy...... 4786 Kar-ho Francis Lee, Ka-Wai Yeung, Koon-Ming Kam, Buig-Yu Ma, Ann Dorothy King, Kwok-Hung Yu, Chen Wu Hu, Anil Ahuja

Hierarchical Versus Voxel-Wise Models for DCE-MRI in a Head and Neck Study with Lapatinib ...... 4787 Brandon Whitcher, Volker J. Schmid, David Collins, Matthew Orton, Dow-Mu Koh, Josep M. del Campo, Kevin Harrington, Iman A. El-Hariry

Multiparametric Non Invasive MRS Evalutation of Cisplatin Treatment in Ovarian Cancer...... 4788 Maria Elena Pisanu, Rossella Canese, Alessandro Ricci, Massimo Giannini, Luisa Paris, Massimo Spada, Carmela Rozera, Albino Cesolini, Filippo Belardelli, Paola Alberti, Delia Mezzanzanica, Silvana Canevari, Egidio Iorio, Franca Podo

Dynamic-Contrast Enhanced MRI and MR-Guided Biopsy in the Detection of Local Recurrence After Radiation Therapy for Prostate Cancer ...... 4789 Derya Yakar, Thomas Hambrock, Henkjan Huisman, Tom Scheenen, Christina Hulsbergen-vandeKaa, Emile van Lin, Jelle Barentsz, Jurgen Fütterer

Effects of Intensity Modulated Radiotherapy (IMRT) on Prostate Volume –Comparison of 39 Patients Before and After Radiotherapy ...... 4790 Christian M. Zechmann, Khurram Aftab, Patrik Zamecnik, Frederik L. Giesel, Christian Thieke, Jurgen Fütterer, Anette Kopp- Schneider, Stefan Delorme

Change in ADC Values in the Prostate During Radiotherapy...... 4791 Daniel Wilson, Sarah Bacon, Alastair McCabe, Brendan Carey

Volume 9

Assessment of Radiotherapy Treatment in Cervical Cancer Using Proton Magnetic Resonance Spectroscopy at 3 Tesla: A Pilot Study...... 4792 Yao Ding, Robert doug Sims, Jaya Lea, Paul Weatherall, Ralph Mason

3.0T MR Diffusion-Weighted Imaging in Monitoring Diffusion Changes in Lung Carcinoma After Chemoradiation ...... 4793 Qing Chang, Ning Wu, Han Ouyang, Yao Huang

Delay and Dispersion Correction for Simultaneous Quantification of Perfusion and Permeability in the Prostate Using DCE-MRI with a Dual-Contrast Sequence...... 4794 Lutz Lüdemann, Tobias Franiel, Matthias Taupitz, Hagen Rehbein, Dirk Beyersdorff

Evaluation of Slope-Based Hepatic Perfusion Index Quantification Methods Against Dual-Input Kinetic Model Based Approach...... 4795 Keiko Miyazaki, Matthew R. Orton, Dow-Mu Koh, V Lewington, David Atkinson, David J. Hawkes, Martin O. Leach, David J. Collins

The Effect of Image Registration on Pharmacokinetic Parameter Extraction Using 3D DCE-MRI ...... 4796 Andrew Melbourne, Matthew Orton, David Collins, Dow-Mu Koh, Martin Leach, David Hawkes, David Atkinson

Assessing the Effects of Water Exchange on Quantitative Dynamic Contrast Enhanced MRI (DCE-MRI) by Comparison with DCE-CT...... 4797 Lauren Jean Bains, Deirdre M. McGrath, Josephine H. Naish, Susan Cheung, M B. Taylor, J P. Logue, Geoff J M Parker, John C. Waterton, David L. Buckley

Comparison of Blood Flow Measurements Using 2-Compartment Model and Deconvolution Based Analysis of T1- Weighted DCE MRI of Breast Tumors...... 4798 Smitha Makkat, Robert Luypaert, Johan De Mey, Steven Sourbron

Quantitative MRI Assays of Angiogenesis with Microscopic Correlation in a Bevacizumab-Treated Human Breast Cancer Model...... 4799 Hans-Juergen Raatschen, Barbara Sennino, Yanjun Fu, David M. Shames, Robert C. Brasch

DCE and DWI in Evaluating Grades of Gliomas ...... 4800 Bob Lei Hou, Li Meng, Sasan Karimi, Weihua Liao, XiaoYi Wang

Systematic DCE-MRI Parameter Errors Caused by Disproportionate Transverse Relaxation (T2) Quenching of Tissue Compartmental Water Proton Signals...... 4801 Xin Li, Ryan A. Priest, Faisal Siddiqui, Tomasz M. Beer, Mark G. Garzotto, William J. Woodward,William D. Rooney, Charles S. Springer Jr.

Hepatic Perfusion Quantification Using a Dual-Input Kinetic Model with a Novel Portal Venous Estimation Method: Evaluation Against Other Model- And Slope-Based Perfusion Quantification Approaches...... 4802 Keiko Miyazaki, Matthew R. Orton, Dow-Mu Koh, V Lewington, David Atkinson, David J. Hawkes, Martin O. Leach, David J. Collins

Contrast Enhanced Image Registration Using Kullbach-Leibler Assisted Image Matching and Patching (KLAMP)...... 4803 Andrew Melbourne, David Collins, Martin Leach, Dow-Mu Koh, David Hawkes, David Atkinson

Applications of Dynamic Contrst-Enhanced MRI in Assessment of Spinal Bone Marrow...... 4804 Kyung K. Peck, Gregg Slater, Xiuyuan Wang, SeungEun Kim, Josh Yamada, Mark Bilsky, Eric Lis, Sasan Karimi

Enhancing Fraction Predicts Recurrence-Free Survival in Patients with Carcinoma of the Cervix Treated with Radiotherapy...... 4805 Stephanie B. Donaldson, James P.B. O'Connor, Catharine M.L. West, Bernadette M. Carrington, Susan E. Davidson, Andrew P. Jones, David L. Buckley

Galbumin, a New Blood Pool Agent, Extravasates from Tumour Vasculature ...... 4806 Firas Moosvi, Jennifer Baker, Stefan A. Reinsberg

Vessel Size Index and Blood Volume Imaging in Pancreatic Cancer Xenograft Model Using Ferumoxide...... 4807 Andrew C.H. Yung, Jenny C.H. Tso, Jennifer Flexman, Sylvia Ng, Donald Yapp, Piotr Kozlowski

Reproducibility and Cross-Validation of DCE-MRI and DCE-CT Perfusion Parameters in a Rat Tumor Model ...... 4808 Chaan S. Ng, Jim A. Bankson, Vikas Kundra, John C. Waterton, Ed F. Jackson

Measuring Non-Invasively Tumor Perfusion and Diffusion as a Function of Tumor Progression Using Proton Magnetic Resonance Imaging (1H MRI) ...... 4809 Asif Rizwan, Hyung JoonCho, Ellen Ackerstaff, Jason Koutcher

Improved Characterization of Breast Lesions with Relative ADC Accounting for Tissue Composition Variationq...... 4810 Jie Huang, Lori Hoisington, Tobias Hahn, Anna Babayan, Kevin Berger

The Role of Diffusion Weighted Imaging (DWI) and Volumetric Measurement in the Early Assessment of Tumor Response in Patients with Locally Advanced Breast Cancer (LABC) Undergoing Primary Chemotherapy (PCT)...... 4811 Laura Martincich, Ilaria Bertotto, Filippo Montemurro, Lisa Cellini, Ivana Sarotto, Daniele Regge

Determination of the Optimum B-Value for Diffusion Weighted Image of the Breast ...... 4812 Reiko Woodhams, Mayumi Satou, Hirofumi Hata, Satoko Kakita, Naoko Yoshimura, Keiichi Iwabuchi, Masanori Ozaki, Shinichi Kan

Microperfusion-Induced Elevation of ADC Is Suppressed After Contrast in Breast Carcinoma ...... 4813 Sachiko Yuen, Mariko Goto, Kei Yamada, Akiko Takahata, Kaori Nishida, Tsunehiko Nishimura

Measuring Water T2 and Water:fat Signal Ratios with MR Spectroscopy (TEAPRESS) and Chemical Shift Imaging (IDEAL): Preliminary Results in Phantoms and Breast Cancer Chemotherapy Patients ...... 4814 David John Manton, Gary Paul Liney, Peter Gibbs, Martin Lowry, Martin Darren Pickles, Lindsay W. Turnbull

Quantitative Proton Single-Voxel MR Spectroscopy in Malignant Breast Tumors at 3T: A Preliminary Study...... 4815 Hyeon-Man Baek, Hon J. Yu, Shadfar Bahri, Jeon-Hor Chen, Orhan Nalcioglu, Min-Ying Su

Quantification of Absolute Concentration of Choline for Differentiation of Malignant, Benign and Normal Breast Tissues by In-Vivo Proton MR Spectroscopy...... 4816 Rani Gupta Sah, Uma Sharma, Rajinder Parshad, Naranamangalam R. Jagannathan

Statistical Analysis of Two Dimensional MR Spectroscopy Combined with Dynamic Contrast Enhanced MRI in Breast Cancer Detection ...... 4817 Xiaoyu Liu, Scott Lipnick, James Sayre, Nanette Debruhl, Aparna Singhal, Albert Thomas

Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Breast at 3.0 Tesla: Combination of High Temporal- And Spatial Resolution - A New Approach...... 4818 Guenther Grabner, Katja Pinker, Stephan Gruber, Wolfgang Bogner, Thomas Helbich, Siegfried Trattnig

Pharmacokinetic Parametric Mapping and Pixel Histogram Analysis for Benign and Malignant Breast Lesion Discrimination: A Preliminary Shutter-Speed DCE-MRI Study ...... 4819 Ian Tagge, Yiyi Chen, Xin Li, Elizabeth Morris, Alina Tudorica, Charles Springer, Wei Huang

A High Specificity Biomarker for Breast Cancer Diagnosis: Shutter-Speed DCE-MRI Discrimination Among Seventy Seven Suspicious Lesions...... 4820 Wei Huang, Xin Li, Alina Tudorica, Elizabeth Morris, Yiyi Chen, Ian Tagge, Sunitha Thakur, Maayan Korenblit, Ya Wang, Zhigang Zhang, Jason Koutcher, Charles Springer

Kinetics and Morphology of Biopsy-Proven DCIS on Preoperative MRI: Can We Predict Occult Invasive Disease?...... 4821 Dorota Jakubowski Wisner, Belinda Chang, Hilda Tso, Christopher Flowers, Bonnie N. Joe, Juan Lessing, Jessica Gibbs, Kaoru Itakura, Shelley Hwang, Nola Hylton

Feasibility of MRI-Guided Large Core-Needle Biopsy of Suspiscious Breast Lesions at 3T...... 4822 Nicky HGM Peters, Carla Meeuwis, Chris JG Bakker, Willem PThM Mali, Arancha M. Fernandez-Gallardo, Richard van Hillegersberg, Marguerite E.I. Schipper, Maurice A.A.J. van den Bosch

3T Breast MRI Using Dixon Technique...... 4823 Basak Dogan, Jingfei Ma, Ken Hwang, Wei Tse Yang

Characterization of Breast Tumors with a Model-Dependent Analysis of Bolus-Tracking MRI...... 4824 Smitha Makkat, Robert Luypaert, Steven Sourbron, Tadeusz Stadnik, Johan De Mey

Accurately Differentiating Benign from Malignant Contrast-Enhancing Breast Lesions Using an Automated Method of Quantitative Washout Kinetics and Fractional Lesion Volume Analysis ...... 4825 Jie Huang, Tobias Hahn, Lori Hoisington, Kevin Berger

USPIO Enhanced Diffusion MRI Increases the Diagnostic Confidence for Detection of Pelvic Lymph Node Metastases in Patients with Bladder or Prostate Cancer...... 4826 Maria Triantafyllou, Johannes M. Froehlich, Peter Vermathen, Tobias Binser, Frederic Birkhaeuser, Achim Fleischmann, Urs E. Studer, Harriet C. Thoeny

Evaluating Prognostic Biomarkers of Prostate Cancer Behaviour: Use of Magnetization Transfer and Diffusion Weighted Contrast...... 4827 Sophie Riches, Vonnie A. Morgan, David J. Collins, Sharon Giles, Nandita M. DeSouza

Significantly Better Local Prostate Cancer Staging Performance with T2-Weighted 3T Endorectal Coil MR Imaging Compared with Real-Time Gray-Scale Tissue Harmonic Imaging TRUS...... 4828 Stijn Wilhelmus Heijmink, Tom W. Scheenen, Thomas Hambrock, Christina A. Hulsbergen-van de Kaa, J A. Witjes, Jelle O. Barentsz

Evaluation of the Prostate After Treatment with High-Intensity Focussed Ultrasound (HIFU) Therapy Using Whole Prostate Diffusion Weighted Imaging (DWI) Analysis ...... 4829 Alex Chapman, Nina Tunariu, Veronica Morgan, Nandita Desouza

Monitoring Prostate Cancer Progression with Diffusion Weighted Imaging: Utility of Fast and Slow Diffusion Components of the Apparent Diffusion Coefficient...... 4830 Veronica Anna Morgan, Sophie F. Riches, Sharon Giles, Nicholas Van As, Chris Parker, Nandita M. DeSouza

Shape-Based Interpolation of MRI Volumes in TRUS/Fusion Based Biopsy...... 4831 Xin Chen, Ramkrishnan Narayanan, John Kurhanewicz, Katsuto Shinohara, David Crawford, Anne Simoneau, Jasjit S. Suri

Identification and Analysis of Metabolic Biomarkers for Predicting Prostate Cancer Grades Using 1H HR-MAS Spectroscopy of Biopsy Tissues...... 4832 Vickie Zhang, Maria Grinde, Laura Tabatabai, Jeff Simko, Mark Albers, Daniel Vigneron, John Kurhanewicz

Asymmetry of Obturator Muscle Perfusion During Prostate MRI: Implications for the Reliability of Pharmacokinetic Analysis ...... 4833 Y Pang, B Turkbey, M Bernardo, D Thomasson, P Choyke

Accuracy of MRI/3D-MRSI Based TRUS-Biopsy in Peripheral Zone (PZ) and Transition Zone (TZ) of Prostate Gland in Patients Suspected for Cancer with Prior Negative Biopsy...... 4834 Claudia Testa, Raffaele Lodi, Caterina Tonon, Riccardo Schiavina, Giuseppe Martorana, Alessandro Franceschelli, Antonietta Derrico, Romeo Canini, Bruno Barbiroli

High-Resolution Diffusion-Weighted Imaging for the Diagnosis of Prostate Cancer ...... 4835 Carolin Reischauer, Bertram Jakob Wilm, Johannes M. Fröhlich, Peter Boesiger, Klaus U. Wentz

A Pattern Recognition Model for Automatic Classification of 1H MRSI Voxels in the Prostate ...... 4836 Lukasz Matulewicz, Kristen L. Zakian, Amita Shukla-Dave, Jacobus F.A. Jansen, Yousef Mazaheri, Hedvig Hricak, Jason Koutcher

Diffusion Weighted Imaging (DWI) of the Prostate Cancer at 3 T; Comparative Study with DWI at 1.5 T...... 4837 Atsushi Nakamoto, Hiromitsu Onishi, Tonsok Kim, Takahiro Tsuboyama, Masatoshi Hori, Yasuhiro Nakaya, Noboru Maeda, Hiroki Higashihara, Mitsuaki Tatsumi, Keigo Osuga, Kaname Tomoda,Hironobu Nakamura

Volumetric 3D T2-Weighted Sequence of the Prostate (SPACE): Comparison with Conventional 2D T2 for Image Quality and Tumor Detection ...... 4838 Jeffry M. Neil, Andrew Rosenkrantz, Xiangtian Kong, Jonathan Melamed, Samir Taneja, Herbert Lepor, Bachir Taouli

Correlation of Gleason Score and Tumor Size with High Resolution 3T Magnetic Resonance Image-Detected Prostate Cancer ...... 4839 Elizabeth Genega Genega, Nicholas Bloch, William DeWolf, R Elliot, Y Fu, Martin Sanda, A Tomaszewski, Andrew Wagner, Ivan Pedrosa, Neil Rofsky

Comparison of Unidirectional Diffusion Weighting with Isotropic Diffusion Weighting for the Detection of Prostate Tumors...... 4840 Marielle E.P. Philippens, Taro Takahara, Greetje Groenendaal, Uulke A. van der Heide

Changes in Dynamic Contrast Enhanced MRI Paramters in the First 8 Weeks of Prostate Radiotherapy...... 4841 Masoom A. Haider, Peter Chung, Warren Foltz, Anna Kirilova, Charles Catton, Padraig Warde, Andrew Bayley, Robert Bristow, Michael Milosevic, Cynthia Menard

Magnetic Resonance Spectroscopy with Receive Arrays: How to Combine the Signals...... 4842 Christopher Thomas Rodgers, Stefan Neubauer, Matthew D. Robson

SNR Improvement of MR Phased Array Spectroscopy Signals ...... 4843 Nicola Martini, Matteo Milanesi, Giulio Giovannetti, Daniele De Marchi, Vincenzo Positano, Luigi Landini, Maria Filomena Santarelli

Combination of Phased-Array Coil Signals in Localized 2D Correlated Spectroscopy: Artifacts and Remedies ...... 4844 Gaurav Verma, Nagarajan Rajakumar, Aparna Singhal, Scott Logan Lipnick, Michael Albert Thomas

Dependence of Rotating Frame Relaxation Rates on Frequency Offset: Spin-Lock Versus Adiabatic Rotation...... 4845 Silvia Mangia, Timo Liimatainen, Michael Garwood, Shalom Michaeli

Whole-Brain N-Acetylaspartate Quantification: Performance Comparison of NAA Versus Lipid Nulling...... 4846 Daniel Rigotti, Jan Hovener, Michael Amann, Peter Bachert, Achim Gass, Oded Gonen

High-Resolution 2D MR Spectroscopy Via Intermolecular Multiple-Quantum Coherences...... 4847 Xi Chen, Meijin Lin, Zhong Chen

Proton MR Spectroscopic Imaging (MRSI) Metabolite Ratios in Human Brain: Calculating Repeatability When Measurement Error Is Proportional to the Mean...... 4848 David John Manton, Gary Paul Liney, Roberto Garcia-Alvarez, Lindsay W. Turnbull

Biochemical, Anatomical and Neuropsychological Correlates in Hepatic Encephalopathy...... 4849 Aparna Singhal, Charles Hinkin, Nagarajan Rajakumar, Rajesh Kumar, Amir Huda, Steven-Huy B. Han, Virginia Elderkin- Thompson, James W. Sayre, Rakesh K. Gupta, Michael Albert Thomas

Improving Spectral Resolution of Proton MRSI by Deconvolving Field Inhomogeneities...... 4850 Zhengchao Dong, Bradley Peterson,

High-Resolution MRS Via Intermolecular Double-Quantum Coherences in Fields Inhomogeneous in Both B0 and B1 ...... 4851 Yanqin Lin, Congbo Cai, Shuhui Cai, Zhong Chen, Jianhui Zhong

A Novel Hybrid Method for Applying Independent Component Analysis to in Vivo Paediatric Brain Tumour 1H Magnetic Resonance Spectra...... 4852 Jie Hao, M P. Wilson, N P. Davies, Y Sun, K Natarajan, L MacPherson, A C. Peet, T N. Arvanitis,

Improved Spectral Resolution in 2D Localized Correlated Spectroscopy Using Enhanced Covariance NMR ...... 4853 Neil Wilson, Enrique Frias-Martinez, Michael Albert Thomas

Relaxation Time Measurements of 31P Metabolites in the Human Calf Muscle at 7 Tesla ...... 4854 Wolfgang Bogner, Marek Chmelik, Albrecht Ingo Schmid, Ewald Moser, Siegfried Trattnig, Stephan Gruber

In Vivo Animal NMR Studies Using Implantable Micro-Coil ...... 4855 Aziz Kadjo, Nicoleta Baxan, Raymond Cespuglio, André Briguet, Colette Rousset, Minh Dung Hoang, Danielle Graveron-Demilly, Latifa Fakri-Bouchet

Differentiation Between Brain Metastasis and Glioblastoma Using MRI and Two- Dimensional Turbo Spectroscopic Imaging Data...... 4856 Jan Luts, Teresa Laudadio, M.Carmen Martínez-Bisbal, Bernardo Celda, Sabine Van Huffel

Performance of the Steighlitz-McBride Algorithm for Spectral Parameter Estimation from a Rapid Multi- Gradient Echo Acquisition ...... 4857 Brian A. Taylor, Ken-Pin Hwang, John D. Hazle, Roger Jason Stafford

Quantification of Short-TE Metabolite Signals in Human Brain Using QUEST and a Simulated Basis Set ...... 4858 Hyeon-Man Baek, Sergey Cheshkov, Audrey J. Chang, Richard W. Briggs

The Quantitative Comparison of Doing Eddy Current Correction Before and After Combination for 1H MRS Using Phased Array Coils with LCModel...... 4859 Lung-Sheng Chang, Cheng-Wen Ko, Shang-Yueh Tsai, Tzu-Chao Chuang, Cheng-Yun Hsu

Exploiting Spatial Information for Estimating Metabolite Concentration in MRSI...... 4860 Anca Croitor Sava, Diana Sima, Jean Baptiste Poullet, Sabine Van Huffel

Statistical Methods to Determine the Reliability of in Vivo Single Voxel MRS Data...... 4861 Johannes Slotboom, Dirk van Ormondt

Systematic Error in the Measurement of [GABA]/[Cr] Ratio Using Methyl Resonance of Creatine ...... 4862 Pallab K. Bhattacharyya

PRESS Spectroscopy of Glutamate: Effects of Voxel Location and Field Strength ...... 4863 Jean D. Jutras, Chris C. Hanstock, Jeff Snyder, Alan H. Wilman

Turbo-Spin-Echo Based Correlated Spectroscopic Imaging of Breast Tissues in Vivo: A Preliminary Study...... 4864 Xiaoyu Liu, Gaurav Verma, Scott Lipnick, Sasd Ramadan, Nanette Debruhl, Michael Albert Thomas

Reproducibility of 3D 1H MR Spectroscopic Imaging of the Prostate at 1.5T...... 4865 Tom WJ Scheenen, Jurgen J. Fütterer, Elisabeth Weiland, Jaoping Lu, Barbara Holshouser, Paul van Hecke, Marc Lemort, Christian M. Zechmann, Heinz-Peter Schlemmer, Geert M. Villeirs, Jelle O. Barentsz, Stefan O. Roell, Arend Heerschap

Comparison Between Internal and External Validation of in Vivo 31P MRS Quantification ...... 4866 Jon Dudley, Wen-Jang Chu, Xin Wang, Matthew M. Norris, Jing-Huei Lee

Absolute Quantification of ATP and Other High Energy Phosphate Compounds in Cat Brain at 9.4T ...... 4867 Xiao-Hong Zhu, Yi Zhang, Wei Chen

Novel 31P Saturation Transfer Strategy for Measurement of Chemical Exchange Reaction Kinetics in Vivo ...... 4868 Qiang Xiong, Qinglu Li, Abdul Mansoor, Fei Du, Wei Chen, Jianyi Zhang,

Enhanced In-Vivo C13 Spectroscopy Using Adiabatic INEPT Sequences and Custom-Made RF Coils...... 4869 Ovidiu C. Andronesi, Dionyssios Mintzopoulos, Hellmut Merkle, A Aria Tzika,

Chemical Shift Change Shows Spatial Orientation of Lipids in Human Brain ...... 4870 Albert J.S. Idema, Jannie P. Wijnen, T. Scheenen, M. van der Graaf, A. Heerschap

Quantum-Mechanical Generalization of the Extended Phase Graph Method (QuaM-EPG) for the Simulation of Coupled Spin Systems Under SSFP Excitation...... 4871 Zenon Starcuk Jr. , Jana Starcukova, Oliver Strbak, Danielle Graveron-Demilly

New Technology: Mass Balance Phenotyping...... 4872 Peter Pediatitakis, Jason H. Winnike, Justyna Wolak, Kayvan R. Keshari, Rex E. Jeffries, Ryan Webb, Greg Young, Haakil Lee, Michael P. Gamcsik, Lee M. Graves, Paul B. Watkins, John Kurhanewizcz, Jeffrey M. Macdonald

An RF-Over-Fiber System for Reliable Signal Injection in ERETIC Spectroscopy ...... 4873 Matteo Pavan, Susanne Heinzer - Schweizer, Nicola De Zanche, Anke Henning, Peter Boesiger, Klaas Paul Pruessmann

Detection of Serine Isotopomers as a Measure of Mitochondrial Function...... 4874 Christopher Bryce Johnson, Peter Pediaditakis, Andrey Tikunov, Douglas Romney, Haakil Lee, Ekhson Holmuhamedov, Mike Gamcsik, Jeffrey MacDonald

Application of Stable Isotope Labelling in Cell Culture Experiments: [2-13C] pyruvate as Novel and Superior Substrate for in Vitro Metabolic Studies in Primary Mouse Hepatocytes...... 4875 Sven Gottschalk, Dieter Leibfritz, Claudia Zwingmann, Marc Bilodeau

Mass Balance Phenotyping of Primary Human Hepatocytes in 2D Cultures Treated with Acetaminophen...... 4876 Jason Hyun Winnike, Peter Pediaditakis, Paul Brent Watkins, Jeffrey Marshall Macdonald

Protective Effect of Hypothermia on Ammonia Toxicity and Energetic Disturbances in Astrocytes ...... 4877 Jessica Heins, Dieter Leibfritz, Claudia Zwingmann

Optimisation and Evaluation of Diffusion-Weighted Magnetic Resonance for Assessing Mobile Lipid Resoanances in Cancer ...... 4878 Dominik Zietkowski, Thomas R. Eykyn, Nandita M. deSouza, Geoffrey S. Payne

High Resolution MR Spectroscopy Reveals Radiation Induced Metabolic Changes in Mouse Liver Tissues ...... 4879 Poonam Rana, Ahmad Raza Khan, Poonam Singh, Shubhra Chaturvedi, Rajendra Prasad Tripathi, Subash Khushu

Exploration of the Effect of Whole Body Ionising Radiation Exposure on the Metabolism of Renal Tissue in Mice Using High Resolution 1H NMR Spectroscopy...... 4880 Poonam Rana, Ritika Agarwal, Ahmad Raza Khan, Shubhra Chaturvedi, Rajendra Prasad Tripathi, Subash Khushu

Increasing Indices of Bile Constituents Following Decompression Therapy Are Indicators of Restorative Function of Hepatocytes: 1H and 31P NMR Studies<...... 4881 Pratima Tripathi, Lakshmi Bala, Gourdas Choudhuri, C. L. Khetrapal

The Effect of pH on the Analysis of 1H MRS Data of Urine in Biomedical Applications ...... 4882 Omkar B. Ijare, Tom Blydt-Hansen, Tedros Bezabeh

Proton NMR Spectroscopic Analysis of Pus for Differentiation Between Amoebic and Pyogenic Liver Abscesses...... 4883 Santosh Kumar Bharti, Virendra Jaiswal, Ujjala Ghoshal, Raja Roy, S K. Mandal, S S. Baijal, U C. Ghoshal, C L. Khetrapal

MRS of Neuronal Progenitor Cells in Vivo ...... 4884 Wolfgang Weber-Fahr, Jens Benninghoff, Kai Schönig, Gabriele Ende, Sascha Sartorius

NAFLD Metabolic Signatures by HR-MAS Molecular Profiling ...... 4885 Jose Manuel Morales, Juan del Olmo, Jose Manuel Rodrigo, Bernardo Celda, Daniel Monleon

NMR Based Metabonomic Investigation on the Biochemical Effects Induced by Radiation Exposure in Mouse Serum...... 4886 Ahmad Raza Khan, Poonam Rana, Shubhra Chaturvedi, Rajendra Prasad Tripathi, Subash Khushu

NMR-Based Metabolomics of Bacterial Infections Studied in a Mouse-Model ...... 4887 Verena Hoerr, Graciela Andonegui, Lori Zbytnuik, Paul Kubes, Brent W. Winston, Hans J. Vogel

Metabonomic Differentiation of Long-Term Dietary Intervention with NMR Spectroscopy of Human Urine Samples ...... 4888 Jingjing Xu, Shuhui Cai, Jiyang Dong, Xuejun Li, Zhong Chen

Metabolism of Abnormal and Normal Colonic Mucosa of Patients with Ulcerative Colitis (UC) and Crohn’s Disease (CD): An In-Vitro Proton MRS Study ...... 4889 Uma Sharma, Rajiv R. Singh, Vineet Ahuja, Govind K. Makharia, Naranamangalam R. Jagannathan

High Spatial Resolution Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) in Human Brain at 3 Tesla Using 32- Channel RF Coil Array...... 4890 Akio Ernesto Yoshimoto, Andre van der Kouwe, Arvind Caprihan, Fa-Hsuan Lin, Lawrence L. Wald, Stefan Posse

Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) in Human Breast...... 4891 Chenguang Zhao, Patrick Bolan, Laurel Sillerud, Melanie Royce, Anne Marie Wallace, Steven Eberhardt, Robert Rosenberg, Philip Heintz, Lomo Lesley, Stefan Posse

Short TE Volumetric Spiral 1H MR Spectroscopic Imaging of the Human Brain at 3T Using Semi-LASER ...... 4892 Mohamed Tachrount, Laurent Lamalle, Jan Warnking, Christoph Segebarth

High Field MR Spectroscopy of the Human Brain at Short TE and TR ...... 4893 Vincent Oltman Boer, Jetse Sigiward van Gorp, Peter R. Luijten, Dennis Klomp

Comparison of TE-Averaged with Short TE Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) for Mapping Glutamate in Human Brain...... 4894 Kaung-Ti Yung, Shang-Yueh Tsai, Fa-Hsuan Lin, Pierre-Gilles Henry, Akio Yoshimoto, Stefan Posse

Multi-Echo Acquisition Based J-Resolved Spectroscopic Imaging on a Whole-Body 3T Scanner...... 4895 Gaurav Verma, Saadallah Ramadan, Nagarajan Rajakumar, Scott Logan Lipnick, Xiaoyu Sherry Liu, Michael Albert Thomas

Echo-Planar Based Correlated Spectroscopic Imaging (EP-COSI): Implementation and Evaluation in Human Skeletal Muscle Using a 3T MRI Scanner and a 8-Channel Knee Coil...... 4896 Scott Logan Lipnick, Saad Ramadan, Guarav Verma, Michael Albert Thomas

31P Spectroscopic Imaging with GRAPPA ...... 4897 Rahul Srinivasa Raghavan, Anshuman Panda, Julien Valette, Judy R. James, Keith Heberlein, Uwe Boettcher, Pierre-Gille Henry, Navin Bansal, Ulrike Dydak

Repeated Measures Performance of Whole-Brain Echo-Planar Spectroscopic Imaging at 4 Tesla...... 4898 Andreas Ebel, Norbert Schuff

Accelerating TE-Averaged 2D Magnetic Resonance Spectroscopic Imaging Using Data-Sharing ...... 4899 Kuang-Ta Kuo, Shang-Yueh Tsai, Yi-Ru Lin

In Vivo Fourier Shifted Two-Dimensional Zero-Quantum Coherence 1H NMR Spectroscopy of Glutamate and Glutamine ...... 4900 Sarah Rebecca Snyder, Sebastian Schmitter, Armin Nagel, Peter Bachert

Detection of Glutathione with High Precision in the Anterior Cingulate Using Short TE 1H MRS at 3T...... 4901 Ralf Mekle, Giulio Gambarota, Tanja Teichmann, Kim Q. Do, Rolf Gruetter

Correction of Frequency Drifts Induced by Gradient Heating in 1H Spectra Using Interleaved Reference Spectroscopy...... 4902 Thomas Lange, Maxim Zaitsev, Martin Buechert

VERSE Implementation for STEAM at 7 T...... 4903 Oleksandr Khorkhordin, Frank Godenschweger, Kai Zhong, Oliver Speck

Bo Anchored Spatial Excitation for Spectroscopic Imaging Under Field Inhomogeneity...... 4904 Arnaud Guidon, Allen W. Song

Stereoscopic Acquisition and Display of MR Spectroscopic Images ...... 4905 Richard A. Edden, Paul A. Warren, Christopher John Evans

J-Resolved 1H Spectroscopic Imaging of Human Brain...... 4906 Atilla Gonenc, Sulaiman Sheriff, Varanavasi Govind, Andrew A. Maudsley

Breast Tissue Classifications by CART Analysis of Localized 2D COSY...... 4907 Xiaoyu Liu, Scott lipnick, James Sayre, Shida Banakar, Nanette Debruhl, Michael Albert Thomas

Two-Dimensional Fitting for in Vivo NMR Spectra Quantification...... 4908 Antonio Napolitano, D Auer, W Koeckenberger

The Linear Relationship Between Cross-Peak Volume and Concentration of Metabolites in 2D Localized MR Spectroscopy...... 4909 Hui Liu, Jeon-Hor Chen, Hyeon-Man Baek, Mark J. Hamamura, Seung-Hoon Ha, Min-Ying Lydia Su, Orhan Nalcioglu

Measurements of IMCL in Tibialis Anterior in Normal and Ob/ob Mice Using a Cryogenic Surface Coil at 9.4 T...... 4910 Qiong Ye, Christof Baltes, Thomas Mueggler, Markus Rudin,

How Much Fat Is Under the Water Peak in Liver Fat MR Spectroscopy?...... 4911 Michael Simca Middleton, Gavin Hamilton, Mark Bydder, Claude B. Sirlin

Estimation of Intrinsic Relaxation Parameters of Human Brain Metabolites in Vivo...... 4912 Silvia Mangia, Michael Garwood, Pierre-Gilles Henry, Kamil Ugurbil, Shalom Michaeli

Automatic Detection of Lipid Peaks in MR Spectroscopic Image Data Using Artificial Neural Networks...... 4913 Balasrinivasa R. Sajja, Himanshu Bhat, Michael D. Boska, Ponnada A. Narayana

Study of the Characteristics of Normal Breast Tissue During Various Phases of Menstrual Cycle by in Vivo Volume Localized Proton MR Spectroscopy (MRS) ...... 4914 Naranamangalam R. Jagannathan, Mahesh Kumar, Uma Sharma, Rani Gupta Sah

Reduction of Endorectal Surface Coil Artifact in 1H Spectroscopic MRI of Prostate Cancer ...... 4915 Galen Durant Reed, John Kurhanewicz, Daniel B. Vigneron, Susan M. Noworolski

Quantitative Magic Angle Spinning Detection of Deuteration in Small Biopsies of Rat Brain...... 4916 Maria Rosa Fayos Carrio, Valeria Righi, Adele Mucci, Luisa Schenetti, Sebastián Cerdán

A Comparison Between Simulated and Experimental Basis Sets for the Analysis of Short-Echo In-Vivo MRS Data at 1.5T ...... 4917 Martin Wilson, Nigel P. Davies, Yu Sun, Kal Natarajan, Theo N. Arvanitis, Andrew C. Peet

Absolute Quantification of 1H Magnetic Resonance Spectroscopy of Human Brain Using qMRI...... 4918 Anders Tisell, Olof Dahlqvist Leinhard, Marcel Warntjes, Janne West, Peter Lundberg

Comparing Methods for Absolute Quantification of Brain Metabolites in Grey and White Matter ...... 4919 Claudia Testa, Emil Malucelli, David Neil Manners, Caterina Tonon, Raffaele Lodi, Bruno Barbiroli, Stefano Iotti jMRUI Version 4 : A Plug-In Platform...... 4920 Dan Stefan, Adrian Andrasecu, Emil Popa, Andrii Lazariev, Oliver Strbak, Zenon Starcuk, Miquel Cabanas, Dirk Ormondt, Danielle Graveron-Demilly

In Vitro Spectroscopic Method Under Clinical Conditions for in Vivo Mannitol Detection...... 4921 Gabriela Hossu, François Kauffmann, Nicolas Courouble, Caroline Henry, Mikael Jokic, Antoine Coquerel, Pierre Denise, Jean- Marc Constans,

Solid-State NMR Adiabatic TOBSY Provides Enhanced Sensitivity for Multidimensional High-Resolution Magic- Angle-Spinning H1 MR Spectroscopy in Burn Trauma ...... 4922 Valeria Righi, Ovidiu C. Andronesi, Dionyssios Mintzopoulos, A. Aria Tzika

Determinants of Magnetization Transfer Efficiency in Tissue and Cells...... 4923 Jin-Hong Chen, Rachael O'Connor, Penelope DeCarolis, Samuel Singer

Detection of Glycine Residue of Glutathione in Vivo ...... 4924 Lana G. Kaiser, Susanne Mueller, Gerald B. Matson, Karl Young

Fat Composition Assessment by 1H and 13C Spectroscopy in Mice ...... 4925 Marina Benito, Sonia Fernández, Paula Montesinos, Juan Jose Vaquero, Cristina Chavarrias, Manuel Desco

MR Elastography Sampling Requirements: Preliminary Investigations...... 4926 Kevin John Glaser, Armando Manduca, Richard Lorne Ehman

Data Reduction Analysis for Brain MR Elastography...... 4927 Matthew C. Murphy, Kevin J. Glaser, Armando Manduca, Joel P. Felmlee, Richard L. Ehman

Analysis of the Capability of Transurethral MR Elastography to Detect and Quantify Localized Stiffness Changes for Prostate Imaging...... 4928 Arvin Arani, Rajiv Chopra, Donald Plewes

Simulation of Wave Fields Observed in Brain MR Elastography by 3D Finite Element Analysis...... 4929 Uwe Hamhaber, Dieter Klatt, Sebastian Papazoglou, Ingolf Sack, Jürgen Braun

Computer Simulation of Breast Compression Based on Segmented Breast and Fibroglandular Tissues on MRI...... 4930 Tzu-Ching Shih, Dongxu Liu, Jeon-Hor Chen, Lizhi Sun, Ke Nie, Huiming Yin, Daniel Chang, Orhan Nalcioglu, Min-Ying Lydia Su

Magnetic Resonance Poroelastography of the Feline Brain ...... 4931 Phillip Robert Perrinez, S. Scott Lollis, Francis E. Kennedy, John B. Weaver, Ketih D. Paulsen

MRI-Based Noninvasive Measurement of Intracranial Compliance from the Relationship Between Transcranial Blood and CSF Flows: Modeling vs Direct Approach...... 4932 Rong-Wen Tain, Noam Alperin

Evaluation of Intracavitary Pneumatic Actuators for Prostate MR Elastography ...... 4933 Rajiv Chopra, Ali Punjani, Arvin Arani, Anthony Chau, Donald Plewes

Triple-Quantum-Filtered Sodium MRI of the Human Brain at 4.7T ...... 4934 Adrian Tsang, Rob Stobbe, Christian Beaulieu

Investigation of a Non-Alcoholic Fatty Liver Disease Model Using 23Na, 1H and 31P MR Techniques...... 4935 Paige Hopewell, Navin Bansal

Evaluation of Severe Anemia by Quantitatively Measuring Multi-Organ Oxygen Using 19 F MRI in a Rat Model ...... 4936 Siyuan Liu, Sameer J. Shah, Lisa J. Wilmes, Vikram Kodibagkar, Michael F. Wendland, Nola Hylton, Harriet W. Hopf, Ralph P. Mason, Mark D. Rollins

Single-Point 19F Imaging of Fluorinated Drugs Injected Into the Eye for the Treatment of Macular Degeneration...... 4937 Gerrit Hendrik van de Maat, Annette van der Toorn, B A. Zonnenberg, Peter R. Seevinck, Wouter Bult,J Frank Nijsen, Hendrik de Leeuw, Chris J. Bakker

A SNR Comparison Study of Multiple Mouse Embryo MRI...... 4938 Xiaoli Zhang, Jurgen E. Schneider, Angela Franklyn, R Mark Henkelman

Structural Characterization of Single Calcium Alginate Beads by 2.35 T MRI and MRS Methods...... 4939 Matteo Bascelli, Antonietta Fracassi, Leonardo Adamo Pajewski, Antonello Sotgiu, Marcello Alecci

Metabolic Spatial Heterogeneities in Brain Tumours Biopsies by NMR Microscopy...... 4940 Bernardo Celda, MCarmen Martinez-Bisbal, Beatriz Martinez-Granados, Vicent Esteve

MR Microscopy in Studying the Development of the Chick Inner Ear ...... 4941 Jerod Rasmussen, Vinod Kaimal, Scott K. Holland, Jaye Ward, Daniel Choo

Uncertainty in VFA T1 Mapping with Multiple Flip Angles...... 4942 Matthias Christian Schabel, Glen R. Morrell

Improved Quantification of Pharmacokinetic Parameters at 3 Tesla Considering B1 Inhomogeneities ...... 4943 Robert Merwa, Gernot Reishofer, Thorsten Feiweier, Karin Kapp, Franz Ebner, Rudolf Stollberger

Using DCE-MRI as a Method for Sequential in Vivo Evaluation of New Angiogenesis After Sinus Lift Augmentation...... 4944 Ulrike Fasol, Dagmar Fisch, Juergen Hennig, Moritz Palmowski, Michael Vogeler, Rainer Schmelzeisen, Ralf Gutwald, Sebastian Sauerbier

Quantitative Analysis of Pulmonary Perfusion Using First Pass Perfusion Magnetic Resonance Imaging ...... 4945 Jie J. Cao, Yi Wang, William Schapiro, Jeannette McLaughlin, Joshua Cheng, Michael Passick, Nathaniel Reichek

Contrast Enhanced MRI Signal Dynamics of FUS-Induced BBB Opening in Mouse Brain...... 4946 Axel Joachim Krafft, Jürgen Walter Jenne, Florian Maier, Marie Nicole Krause, Ana Martin-Villalba, Peter E. Huber, Wolfhard Semmler, Michael Bock

Dynamic Oxygen-Enhanced T1-Weighted MR in Tumour Xenografts...... 4947 Inna Linnik, Jose Ulloa, Marietta Scott, Carsten Liess, Jane Halliday, Josephine H. Naish, John C. Waterton, Geoffrey J.M. J.M. Parker

A Population-Based AIF for Quantitative DCE-MRI of the Rat Abdomen Acquired Using Dynamic High Temporally and Spatially Resolved CT ...... 4948 Jonas Svensson, Andreas Steingötter, Markus Schwaiger, Ernst Rummeny, Rickmer Braren

Influence of Contrast-Dependent T2 Effects on DCE-MRI of the Prostate at 7T ...... 4949 Gregory J. Metzger, Patrick J. Bolan

Functional Proton Electron Double Resonance Imaging: Concept and Experiment ...... 4950 Valery V. Khramtsov, Keerthi Shet, Eric Kesselring, Sergey Petryakov, Ziqi Sun, Jay L. Zweier, Alexandre Samouilov

Slice Selection Using Modulated Gradients for Fast 2D Single Point EPR Imaging ...... 4951 Nallathamby Devasahayam, Sankaran Subramanian, Shingo Matsumoto, Murali Cherukuri Krishna

Investigating DNP Markers for Stem Cell Tracking at Low Field...... 4952 Li Sze Chow, Behrouz Aflatoonian, Harry D. Moore, Martyn N.J. Paley

The Resolution of Oxygen in EPR Images...... 4953 Sankaran Subramanian, Chandramouli Gadisetti, Nallathamby Devasahayam, Shingo Matsumoto,Jeeva Munasinghe, Murali C. Krishna

Using Hyperpolarized [1-13C]Pyruvate as a Dynamic Marker for Intracellular pH...... 4954 Marie Allen Schroeder, Helen J. Atherton, Lisa C. Heather, Mark Aaron Cole, Kieran Clarke, George K. Radda, Damian J. Tyler

Co-Polarization of (1-13C) Pyruvate and 13C Sodium Bicarbonate by Dynamic Nuclear Polarization Allows Simultaneous Assessment of in Vivo PH and Tumor Metabolism...... 4955 David M. Wilson, Kayvan Keshari, Peder E. Larson, Albert P. Chen, Simon Hu, Robert A. Bok, Sarah J. Nelson, Daniel B. Vigneron, John Kurhanewicz

Application of Slice-Localized 13C Dynamic MR Spectroscopy and 2D 13C Dynamic MR Spectroscopic Imaging with Hyperpolarized [1-13C]-Pyruvate in a Human Glioblastoma Xenograft...... 4956 Ilwoo Park, Peder E. Larson, Janine M. Lupo, Robert Bok, Tomoko Ozawa, John Kurhanewicz, Daniel B. Vigneron, C David James, Sarah J. Nelson,

13 Alanine Signal and T2 Relaxation: A Potential Hyperpolarized C Metabolic Marker for Hepatocellular Carcinoma ...... 4957 Yi-Fen Yen, dirk Mayer, Patrick Le Roux, Randy Lee King, Dan Spielman, Jim Tropp, Adolf Pfefferbaum, Ralph E. Hurd, Shreyas Vasanawala

Selective Excitation of [13C]Bicarbonate Following Injection of Hyperpolarized [1- 13C]Pyruvate Allows for Enhanced Signal ...... 4958 Crystal Harrison, Matthew E. Merritt, A Dean Sherry, Craig Malloy,

Use of Hyperpolarized Carbon-13 Magnetic Resonance for Non-Invasive Observation of Metabolic Regulation ...... 4959 Marie Allen Schroeder, Helen J. Atherton, Lisa C. Heather, Julian L. Griffin, Kieran Clarke, George K. Radda, Damian J. Tyler

13 Acute Liver Failure Studied by Hyperpolarized 1,4- C2-Fumarate in CCl4 Injured Rat Liver ...... 4960 Rene in 't Zandt, Magnus Karlsson, Anna Gisselsson, Pernille Rose Jensen, Georg Hansson, Mathilde Lerche

13 13 1,4- C2 Malate Reports on Ischemia Related Reperfusion Injury, After Administration of Hyperpolarized 1,4- C2 Fumarate in Mouse Skeletal Muscle in Vivo ...... 4961 Pernille Rose Jensen, Rene in 't Zandt, Magnus Karlsson, Anna Gisselsson, Georg Hansson, Mathilde Hauge Lerche

Rapid Hyperpolarized-Gas Lung Imaging Using a Parallel-Spiral Acquisition with BOSCO Reconstruction...... 4962 Hao Tan, Weitian Chen, Peng Hu, G. W. Miller, T. A. Altes, J. F. Mata, E. E. de Lange, G. D. Cates, Ray F. Lee, Craig H. Meyer, John P. Mugler III,

Ultrahigh Temporal Resolution Dynamic Imaging of He-3 MRI Using Bolus Delivery ...... 4963 Rafael Luis O'Halloran, James H. Holmes, Eric T. Peterson, Ronald L. Sorkness, Mark L. Schiebler, Sean B. Fain,

Selective Saturation of Xe Dissolved Into Tissue and Xe Bound with Hemoglobin in Human Lungs in Hyperpolarized 129Xe MR ...... 4964 Yulin Chang, Talissa A. Altes, Isabel M. Dregely, Stephen Ketel, Iulian C. Ruset, Jaime F. Mata, F. William Hersman, John P. Mugler III, Kai Ruppert

Hyperpolarized 129Xe MR of the Sickle Cell Disease: Preliminary Findings...... 4965 Yulin Chang, Talissa Altes, Isabel M. Dregely, Stephen Ketel, Iulian C. Ruset, Jaime F. Mata, F.William Hersman, John P. Mugler III, Kai Ruppert

More Than 50 % 13C Polarization in Solution by the DNP-NMR Method: 200,000-Fold Enhancement Compared to 3 T and Room Temperature...... 4966 Jan Henrik Ardenkjaer-Larsen, Sven Macholl, Haukur Johannesson

DNP and EPR Properties of a Biocompatible Macromolecule for EPRI and in Vivo MRI ...... 4967 Björn Dollmann, Andrei Kleschyov, Kerstin Münnemann, Dariush Hinderberger

PASADENA Hyperpolarization: Instrumentation and Preparation of Tracers for in Vivo Application...... 4968 Jan-Bernd Hövener, Eduard Chekmenev, Larry Robertson, Kent Harris, Thao Tran, William Perman, Brian Ross, Pratip Bhattacharya

Optimization of 89Y DNP ...... 4969 Zoltan Kovacs, Steven Reynolds, Matthew E. Merritt

Real Time MR Thermometry for Monitoring Focused Ultrasound in the Liver...... 4970 Andrew B. Holbrook, Juan M. Santos, Elena Kaye, Viole Rieke, Kim Butts Pauly

Localized FFT Phase-Correction Algorithm for Improved Real-Time PRF Shift Thermometry ...... 4971 R. Jason Stafford, Axel J. Krafft, Roger Jason McNichols, Ashok Gowda, Michael Bock, John D. Hazle

A Fast Thermal Imaging Sequence for Focused Ultrasound Ablation of the Liver ...... 4972 Yuval Zur

MR-Guided Focused Ultrasound Ablation of the Rat Liver ...... 4973 Randy L. King, Viola Rieke, Kim Butts Pauly

A Novel Application for MR Thermometry: Post Mortem Interval Estimation in Forensic Medicine ...... 4974 Sara Maria Sprinkhuizen, Hedwig A. Tromp, Chris J. Bakker, Jessica D. Workum, Hendrik de Leeuw, Max A. Viergever, Lambertus Wilhelmus Bartels

Fast Temperature Measurement Using a 2DRF Pulse Enables Both Reduced-FOV Imaging and Fat Suppression...... 4975 Chang-Sheng Mei, Jing Yuan, Nathan J. McDannold, Lawrence P. Panych

Online Phase-Collection Based Correction of MR Thermometry for Breast HIFU Ablation: Evaluation Under Various Respiratory Motion Susceptibility Conditions in Phantom...... 4976 Matthieu Lepetit-Coiffe, Baudouin Denis de Senneville, Philippe Lourenco de Oliveira, Charles Mougenot, Bruno Quesson, Jean Palussiere, Chrit Moonen

Initial Evaluation of a Fast Chemical Shift Thermometry Technique in the Breast ...... 4977 Hua Ai, Brian A. Taylor, Andrew M. Elliott, Huong LePetross, John D. Hazle, Roger Jason Stafford

Increased Applicability of a Manipulator to Assist MR Guided Microwave Ablation of Liver Tumors and Clinical Experiences of 14 Cases ...... 4978 Shigehiro Morikawa, Toshiro Inubushi, Shigeyuki Naka, Koichiro Murakami, Yoshimasa Kurumi, Tohru Tani, Hasnine Akter Haque, Junichi Tokuda, Nobuhiko Hata

Automatic Passive Tracking of an Manually Steerable Instrument Holder for MRGuided Interventions Applied in LITT...... 4979 Axel Joachim Krafft, Florian Maier, Patrik Zamecnik, André de Oliveira, Jürgen Walter Jenne, Roger Jason Stafford, Kamran Ahrar, Axel Winkel, Wolfhard Semmler, Michael Bock

A Technique for Improving 2D X-Ray to 3D MRI Registration in Fluoroscopy-Guided Orthopedic Interventions...... 4980 Martijn John van der Bom, Josien Petronella Pluim, Matthew Gounis, Lambertus Wilbert Bartels

Validation of a Vasculature-Based Co-Registration Technique of X-Ray and MR Images for the Guidance of Cardiovascular Interventions...... 4981 Perry Radau, Andriy Smatukha, Peter Jones, Regis Vaillant, Alexander J. Dick, Graham A. Wright

Automatic Slice Positioning of the Interventional Guidewire Using Passive Paramagnetic Markers...... 4982 Sunil Patil, Oliver Bieri, Permi Jhooti, Klaus Scheffler

Multiparametric Monitoring of Chemical Ablatons Using a Rapid Chemical Shift Imaging Technique...... 4983 Brian A. Taylor, Andrew M. Elliott, John D. Hazle, Roger Jason Stafford

A Reliable Real Time Liver Motion Tracking for Application in Magnetic Resonance Guided High Intensity Focused Ultrasound Therapy...... 4984 Dattesh D. Shanbhag, Rekha Tranquebar, James C. Ross

Compressed Sensing for Highly Accelerated 3D Visualization of 19F-Catheters...... 4985 Carsten Oliver Schirra, David Brunner, Jochen Keupp, Reza Razavi, Tobias Schaeffter, Sebastian Kozerke

The Influence of Background Gradients in Multi Gradient-Echo MR Thermometry...... 4986 Sara Maria Sprinkhuizen, Chris J. Bakker, Lambertus Wilhelmus Bartels

Temperature Error Reduction During MRI Guided HIFU Treatment...... 4987 Xiaodong Zhou, Qiang He, Qiang Zhang, Cheng Ni

Practical Thoughts on Using Repeated Bipolar Gradients for MR-ARFI...... 4988 Jing Chen, Kim Butts Pauly

Measurements of Kinetic Stability, Blood-Brain Barrier Permeability and Cytotoxicity for Two Thulium Based Contrast Agents ...... 4989 Daniel Coman, Margarita Gattas-Sethi, Hubert K.F. Trubel, Peter Herman, Fahmeed Hyder, Garry Kiefer, Francesco d’Errico

Real-Time Non-Subtraction Thermal Ablation Monitoring In-Vivo Using RE-TOSSI ...... 4990 Jamal Jon Derakhshan, Sherif G. Nour, Simi Paul, Stephen R. Yutzy, Jeffrey L. Sunshine, Mark A. Griswold, Jeffrey L. Duerk,

Dynamics and Distributions of Temperature Changes During Pharyngeal Selective Brain Cooling by 1H CSI ...... 4991 Daniel Coman, Hubert K.F. Trubel, Peter Herman, Fahmeed Hyder,

Feasibility Study of a New System for MR-Guided Scanned Focused Ultrasound Hyperthermia in Small Animals ...... 4992 Robert Staruch, Rajiv Chopra

Computer Simulation and Temperature Measurement for MR Hyperthermia Therapy Using Coaxial-Slot Antenna...... 4993 Tae Hyung Kim, Kee Chin Tan, Song I. Chun, Ki Sueng Choi, Yong Hee Han, Chi Woong Mun

Design and Preliminary Clinical Studies of an MRI-Guided Transrectal Prostate Intervention System...... 4994 Axel Krieger, Peter Guion, Csaba Csoma, Iulian I. Iordachita, Anurag K. Singh, Aradhana Kaushal, Cynthia Menard, Gabor Fichtinger, Louis L. Whitcomb

Comparison of Two Real Time Tracking Methods for a Robotic Assistance System ...... 4995 Jaane Rauschenberg, André De Oliveira, Florian Maier, Wolfhard Semmler, Michael Bock

MRI-Guided Monitoring of Cement Injection in Vertebral Bodies ...... 4996 René Schilling, Hermann Josef Bail, Florian Wichlas, Christian Jürgen Seebauer, Jens Rump, Ulf Teichgräber

Nd:YAG Laser Based Laparoscopic Liver Resection in a 1.0 Tesla High Field Open MRI: Evaluation of Suitable Dynamic MR Sequences for Image Guided Surgery...... 4997 Sascha Santosh Chopra, Guido Schumacher, Sven Christian Schmidt, Christian Seebauer, Ioannis Papanikolaou, Ivo Van der Voort, Florian Streitparth, Jens Rump, Ulf Teichgraeber

An Optical and Electromagnetic Hybrid Tracking System for MR Image Guided Interventional Procedures ...... 4998 Shigehiro Morikawa, Hasnine Akter Haque, Shigeyuki Naka, Koichiro Murakami, Yoshimasa Kurumi,Tohru Tani, Toshiro Inubushi

Dual MRI-Tracking/SJM NavX Electro-Physiology Catheters for Navigation Inside an MRI: Initial Experience...... 4999 Ehud Schmidt, Jeremy D. Dando, Robert D. Darrow, Daniel Kacher, Laurence M. Epstein, Ferenc Jolesz, Charles L. Dumoulin, Vivek Y. Reddy

Tracking System for Real-Time MR-Guided Percutaneous Interventions at 1.5T ...... 5000 R. Jason Stafford, Barry Fetics, Amir Roth, Christine Lorenz, Axel J. Krafft, Michael Bock, Kamran Ahrar

MRPen – 3D Marker Tracking for Percutaneous Interventions ...... 5001 Florian Maier, Axel Joachim Krafft, André de Oliveira, Wolfhard Semmler, Michael Bock

Magnetic Resonance Guided Laser Thermal Therapy with Finite Element Simulation for Treatment Planning ...... 5002 Andrew Elliott, Anil M. Shetty, Roger McNichols, David Fuentes, John D. Hazle, R Jason Stafford

Percutaneous Laser Disc Decompression (PLDD) in an Open High-Field MRI...... 5003 Florian Streitparth, Thula Walter, Bernhard Schnackenburg, Bernd Hamm, Ulf Teichgräber

Real-Time Guidance and Thermal Monitoring of Interstitial Laser Ablation of Osteoid Osteomas in an Open High-Field MRI ...... 5004 Florian Streitparth, Bernhard Gebauer, Jens Rump, Sascha Chopra, Florian Wichlas, Bernd Hamm, Ulf Teichgräber

MR-Guided Thermal Ablation in Bone Using a Rapid Chemical Shift Imaging Technique...... 5005 Brian A. Taylor, Andrew M. Elliott, John D. Hazle, Roger Jason Stafford

Intravascular 3.0T MRI Using an MR Imaging-Guidwire...... 5006 Yanfeng Meng, Zhaoqi Zhang, Huidong Gu, Xing Lv, Jue Zhang, Jing Fang, Bensheng Qiu, Xiaoming Yang

Tapering Improves the Forward-Looking Properties of the Interventional Loopless Antennae...... 5007 Di Qian, AbdELMonem M. EL-Sharkawy, Paul A. Bottomley,

High Precision Measurement of Micro-Coil Locations for Real-Time Tracking Applications...... 5008 Melvyn Boon King Ooi, Sascha Krueger, William J. Thomas, Srirama V. Swaminathan, Truman R. Brown,

Interactive MR Image Scan Guidance with a Capability of Motion Compensation Using Endoscout Sensor...... 5009 Hasnine Akter Haque, Shigehiro Morikawa, Shigeyuki Naka, Koichiro Murakami

MR Compatible Phased Array HIFU Transducer for Localized Prostate Cancer Treatment; in Vitro Validation...... 5010 Lorena Petrusca, Rares Salomir, Emmanuel Blanc, Lucie Brasset, Francois Cotton, Jean-Yves Chapelon

3-D Control Over Spatial Heating Using Multi-Element Ultrasound Heating Applicators and Real-Time MR Temperature Feedback...... 5011 Rajiv Chopra, Kee Tang, Matthew Asselin, Mathieu Burtnyk, MIchael Bronskill,

Feasibility of Cardiac-Gated 3T MRI-Guided Myocardial Ablation with High Intensity Focused Ultrasound...... 5012 Aravind Swaminathan, Viola Rieke, Randy Lee King, John Pauly, Kim Butts-Pauly, Michael McConnell

T2-Weighted Imaging of the Left Atrium Acutely After Pulmonary Vein Isolation Demonstrates Wall Thickening and Edema...... 5013 Dana C. Peters, Jeff Hsing, Kraig V. Kissinger, Beth Goddu, Reza Nezafat, Jason E. Taclas, Mark E. Josephson, John V. Wylie, Warren J. Manning

Inductively Coupled Coils for Local SNR-Enhancement During MR-Guided Prostate Biopsy ...... 5014 Reiner Umathum, Axel Joachim Krafft, Andre de Oliveira, Michael Bock

Active Needle for Real-Time MRI-Guided Percutaneous Procedures ...... 5015 Christina Elena Saikus, Kanishka Ratnakaya, Anthony Z. Faranesh, Robert J. Lederman, Ozgur Kocaturk

A Gd-DTPA Based Insoluble Polymer Coating Technique for Endovascular Device Visualization...... 5016 Tomoka Kurita, Kagayaki Kuroda, Takeo Ohsaka

Optimization of Piezoelectric Motors to Enhance MR Compatiblity for Interventional Devices...... 5017 Yi Y. Wang, Mohammed Salman Shazeeb, Christopher H. Sotak, Gregory Scott Fischer

A Fast Clinically Viable 3D T2 Mapping Technique...... 5018 Ravi Teja Seethamraju, Vladimir Jellus, Timothy Hughes, Mukesh G. Harisinghani, Alexander Guimaraes,

Rapid T1 Mapping of Mouse Myocardium with Saturation Recovery Look-Locker Method...... 5019 Wen Li, Jia Zhong, Ming Lu, Mark Griswold, Xin Yu,

Improved Accuracy in T1 Mapping and Flip Angle Correction with Random Spoiling in Radial Gradient Echo Imaging ...... 5020 Wei Lin, Hee Kwon Song

Fast High-Resolution T1 Mapping Using Inversion Recovery Look-Locker Echo-Planar Imaging at a Steady State: Optimization for Accuracy and Reliability ...... 5021 Wanyong Shin, Hong Gu, Yihong Yang

Accuracy of T1 and Equilibrium Magnetization Maps Using a Spoiled Gradient-Recalled Echo Sequence with Variable Flip Angles at 4.7 T, 7 T, and 9.4 T: A Gadolinium-Doped Gel Phantom Study...... 5022 Hideto Kuribayashi, Takuya Minowa, Yoshie Maitani, Masaki Sekino, Hiroyuki Ohsaki, Masayuki Ueda, Yasuo Katayama

Flip Angle Optimisation Using an In-Vivo T1 Distribution-Weighted Approach Based on the Cramer-Rao Lower Bound Theory for Accurate T1 Quantification...... 5023 Keiko Miyazaki, David J. Collins, Dow-Mu Koh, Martin O. Leach, Matthew R. Orton

Simultaneous Quantitation of T1 and T2 Using a Novel 2D Magnetization-Prepared Multi-Slice Pulse Sequence...... 5024 Eric Tzguang Han

T1-Mapping Using Two Flip Angle Spoiled FLASH-EPI Hybrid Sequences ...... 5025 Christine Preibisch, Steffen Volz, Ralf Deichmann

Singleshot Measurements of T1 and Field Variation Using 2D Simultaneous Singleshot Spin-, Gradient-, and Stimulated-EPI (2D ss-SGSTEPI) ...... 5026 Xianfeng Shi, Xin Liu, EunKee Jeong

Fast T1 Mapping Using a CPMG Sequence ...... 5027 Robert L. Greenman, Robert V. Mulkern

Apparent Change in the T1 of Lipids in Mixture ...... 5028 Houchun Harry Hu, Krishna S. Nayak

Quantification of Noise Efficiency with T1 Corrected IDEAL Spoiled Gradient Echo Imaging...... 5029 Curtis Nathan Wiens, Bryan Thomas Addeman, Shawn Joseph Kisch, Catherine D. Hines, Hanzhou Yu, Jean H. Brittain, Scott B. Reeder, Charles A. McKenzie,

Accurate and Efficient Mapping of Flip Angle and T1 Using Simultaneous Actual Flip Angle - Variable Flip Angle Imaging (AFI-T1) ...... 5030 Samuel A. Hurley, Alexey A. Samsonov

Skin T1 Mapping at 1.5T, 3T, and 7T...... 5031 Joelle Karine Barral, Nikola Stikov, Erik Gudmundson, P. Stoica, Dwight George Nishimura

Fast Three-Point Approach for Volumetric T1 Mapping...... 5032 Rahul Sarkar, Alan R. Moody, General Leung

Towards Whole-Brain Quantitative T1 Mapping at 3.0T for Imaging Hippocampal Sclerosis...... 5033 Rebecca Sara Samson, Mark R. Symms, Mahinda Yogarajah, Niels Focke, John S. Duncan

Crushed Early Acquisition Spin Echo (CEASE): A Novel Technique for Positive Contrast and Spectroscopic Imaging of Superparamagnetic Particles...... 5034 Bernard MCW Siow, Aiqing Chen, Gavin Clowry, Li Sun, Andrew M. Blamire

Flow-Insensitve Magnetization Preparation for T2 Contrast ...... 5035 Christian Stehning, Jürgen Rahmer, Ulrike Blume, Tobias Schaeffter

Selective Depiction of Holmium-Loaded Microspheres (HoMS) Using Susceptibility Gradient Mapping (SGM): Initial Experience in Animal Models...... 5036 Peter Roland Seevinck, Gopal Varma, Hendrik de Leeuw, Julien Senegas, Tobias Schaeffter, Chris J.G. Bakker

Quantification of SPIO Using T2 and Phase Imaging...... 5037 Alexia Rodríguez-Ruano, Marina Benito, Cristina Santa Marta, Gema Elvira, Paula Montesinos, Juan Jose Vaquero, Augusto Silva, Manuel Desco

A Three-Field Study of Cerebral Transverse Relaxation Rates in Vivo: Implications for Brain Iron Measurements ...... 5038 Ana Maria Oros-Peusquens, Miriam Rabea Kubach, Maija Laurila, N. Jon Shah

Dependence of Blood R2 Relaxation Rate on Echo Spacing Using a CPMG Sequence at 7T...... 5039 Alexander Graeme Gardener, Susan Tracy Francis, Penny Anne Gowland

Magnetic Field Correlation Contrast in the Human Brain at 7 Tesla...... 5040 Maarten J. Versluis, Andrew G. Webb, Mark A. van Buchem, Matthias J P van Osch

Quantitative Analysis of Transverse Relaxation Due to Strongly Magnetized Micron-Sized Spheres Subjected to Unrestricted Diffusion in Gradient Echo and Spin Echo Imaging:Validation of Theory with Experiments and Monte Carlo Simulation ...... 5041 Peter Roland Seevinck, Koen Lucas Vincken, Gerrit Hendrik van de Maat, Chris J.G. Bakker

SPIO: Positive Contrast by Adiabatic IRON Using Repetitve Inversion Pulses...... 5042 Carsten Warmuth, Arne Hengerer, Robert Krieg, Jörg Schnorr, Michael Reinhardt

Observation of Time Dependent Magnetic Field Correlation in the Human Brain ...... 5043 Kathleen A. Williams, Kamila Szulc, Caixia Hu, Jens H. Jensen, Joseph A. Helpern

Quantification of the Regional Non-Hemin Iron in Human Brain in Vivo Through the Apparent Transverse Relaxation Rate of the Tissue Water at 4.7T...... 5044 Fumiyuki Mitsumori, Hidehiro Watanabe, Nobuhiro Takaya

Estimation of T2 in Severe Iron Overload Patients with Weighed Least Squares T2-IDEAL...... 5045 Huanzhou Yu, Ann Shimakawa, Scott B. Reeder, Jean H. Brittain, Charles A. McKenzie, Shreyas Vasanawala

Assessment of Iron Concentration in a Two-Pool Model of Brain Tissue ...... 5046 Christian Langkammer, Thomas Seifert-Held, Michaela Soellinger, Christian Enzinger, Franz Fazekas, Rudolf Stollberger, Stefan Ropele

Towards Microcalcifcation Detection Using Susceptibility Weighted Phase Imaging: Simulations and Phantom Experiments ...... 5047 Richard A. Baheza, E. Brian Welch, John C. Gore, Thomas E. Yankeelov

Multi-Echo Spin-Echo (MESE) Signal Behavior of Paramagnetic Holmium-166 Loaded Microspheres for Radiotherapy: Experiment and Simulation ...... 5048 Gerrit Hendrik van de Maat, Peter R. Seevinck, Koen L. Vincken, Hendrik de Leeuw, Chris J. Bakker

Simultaneous Spin/Gradient Echo Acquisitions in Conjunction with Arterial Spin Labeling for Quantification of T2 by Single Shot 3D Spiral GRASE Imaging ...... 5049 Johannes Gregori, Norbert Schuff, Matthias Günther

Efficient and Accurate Modeling of Pulsed Magnetization Transfer...... 5050 Dirk K. Müller, André Pampel, Toralf Mildner, Torsten Schlumm, Thies H. Jochimsen, Harald E.Möller

Reliability and Reproducibility of High Resolution Magnetization Transfer Imaging on 3T...... 5051 Ying Wu, Hongyan Du, Kelly H. Zou, Shawn Sidharthan, Eugene Dunkle, Robert Edelman, Ann Ragin

Quantitative Magnetization Transfer Imaging Using Non-Balanced SSFP ...... 5052 Monika Gloor, Klaus Scheffler, Oliver Bieri

Cardiac Magnetization Transfer Imaging Using SSFP at 3T...... 5053 Oliver Michael Weber, Peter Speier, Klaus Scheffler, Oliver Bieri

Intra- And Inter-Scanner Variability of Magnetization Transfer Ratio Using Balanced SSFP ...... 5054 Monika Gloor, Klaus Scheffler, Oliver Bieri

3D Amide Proton Transfer (APT) Imaging of the Whole Brain at 3T...... 5055 He Zhu, Joseph S. Gillen, Peter B. Barker, Peter C.M. van Zijl, Jinyuan Zhou,

Correlation of Potential Myelin Measures from Quantitative Magnetisation Transfer (qMT) and Multi- Component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT)...... 5056 Rebecca Sara Samson, Sean C L Deoni, Claudia A M Wheeler-Kingshott

An Improved Empirical Solution for Describing Chemical Exchange Saturation Transfer (CEST) MRI ...... 5057 Phillip Zhe Sun

Predicting Optimal Properties of CEST MRI Agents Under Practical Experimental Conditions ...... 5058 Phillip Zhe Sun, Guanshu Liu, Jinyuan Zhou, Peter van Zijl, Michael T. McMahon,

Quantitative Pulsed CEST...... 5059 Kimberly L. Desmond, Greg J. Stanisz,

Compensatory Amide Proton Transfer Ratio (CAPTOR) Imaging to Improve the Specificity of Tissue Acidosis MRI ...... 5060 Phillip Zhe Sun, A Gregory Sorensen

In Vivo Myelin Water Imaging Using Z-Shimmed Multi-Gradient-Echo Pulse Sequences at 3T...... 5061 Claudia Lenz, Markus Klarhöfer, Klaus Scheffler

Analytical Method for Correction of B1 Errors in High-Field Magnetization Transfer Ratio Mapping...... 5062 Vasily L. Yarnykh

Molecular Exchange in Breast Cells Studied with a New DW-MRI Method ...... 5063 Daniel Topgaard, Ingrid Åslund, Carin Malmborg, Anna Stenstam, Karin Bryskhe, Stina Oredsson

Incidental Magnetization Transfer Contrast by Fat Saturation Preparation Pulses in Multi-Slice MR Imaging: An Illustration of Look-Locker EPI Sequences ...... 5064 Wanyong Shin, Hong Gu, Yihong Yang

In Vivo Tumor Detection and Characterization by Fixed-Point Imaging Using Active Feedback Fields ...... 5065 Jon Furuyama, Dennis W. Hwang, Yung-Ya Lin

Multi-Parametric Approach to Automatic Regional Analysis of Quantitative Relaxation Times in the Brain ...... 5066 Benjamin Segun Aribisala, Andrew M. Blamire

Phase Contrast in the Post Mortem Rat Brain: Comparison with T2 and Histology...... 5067 Ana Maria Oros-Peusquens, Sebastian Hirsch, Joerg Felder, Avdo Celik, M Cremer, N. Jon Shah

How Reliable Are Current Practices in Reconstructing Relaxation Spectra for Detecting the T2 Myelin Water Signal When Applied to Real in Vivo T2 Decays?...... 5068 Keith S. Cover

Inconsistency in Interpretation of T2 and Diffusion in White Matter...... 5069 Sharon Peled

Variations in T2, T2 and T1 Between White Matter Tracts at 7.0 T...... 5070 Eleanor F. Cox, Pierre-Yves Herve, Peter J. Wright, Ashley Loftipur, Olivier Mougin, Susan E. Pritchard, Tomas Paus, Penny A. Gowland

Quantifying White Matter: Integrating Diffusion Tensor Imaging and Bound Pool Fractions...... 5071 Nikola Stikov, Lee Michael Perry, John Mark Pauly, Brian A. Wandell, Robert F. Dougherty

High Resolution Myelin Water Imaging in Rat Spinal Cord in Vivo with Actively Decoupled Implanted RF Coil ...... 5072 Piotr Kozlowski, Jie Liu, Jenny Ch Tso, Nathan Wolfe, Andrew C. Yung

Intrinsic Connectivity Contrast: A Novel Contrast Mechanism for Investigating a Wide Range of Brain Disorders...... 5073 R. Todd Constable, Yuko Hara, Nallakkandi Rajeevan, Fuyuze Tokoglu, Xenios Papademetris

Pulsed Saturation Transfer for Quantifying CEST in the Presence of MT...... 5074 Kimberly L. Desmond, Greg J. Stanisz,

Multeslice Gradient Echo CEST Imaging ...... 5075 W Thomas Dixon, Ileana Hancu, A Dean Sherry, James Ratnaker, Donald E. Woessner, Elena Vinogradov, Robert E. Lenkinski, David C. Alsop

Using the Linewidth of the Amide Proton CEST Effect of MRI-PARACEST Agents for pH Mapping ...... 5076 Alex Xuexin Li, Craig K. Jones, Mojmir Suchy, Robert H.E. Hudson, Ravi S. Menon, Robert Bartha

Application of Parallel Imaging to Reduce SAR in CEST Experiments...... 5077 Elena Vinogradov, Aaron K. Grant, Phillip M. Robson, Ilena Hancu, W Thomas Dixon, A Dean Sherry, Robert E. Lenkinski

Amide Proton Transfer (APT) MRI: A 3T vs. 7T Comparison ...... 5078 Guang Jia, Jinyuan Zhou, Seongjin Choi, Wenbo Wei, Steffen Sammet, Daniel James Clark, Stefan Fischer, Michael V. Knopp

Modeling the Influence of TR and Excitation Flip Angle on the MTR Obtained from 3D FLASH MRI...... 5079 Gunther Helms, Henning Dathe, Peter Dechent

Optimization of Quantitative Magnetization Transfer Imaging Using a Selective Inversion Recovery Pulse ...... 5080 Ke Li, Zhongliang Zu, Junzhong Xu, John C. Gore, Heather M. Whitney, Daniel F. Gochberg

Impact of Magnetization Transfer on Relaxometry Using Transient Steady-State Free Precession Imaging ...... 5081 Jan Ole Blumhagen, Francesco Santini, Oliver Weber, Klaus Scheffler, Oliver Bieri

The Use of Binomial Pulses for Suppression of Long T2 Signals...... 5082 Atsushi Mark Takahashi

A Flexible Design Algorithm for Single-Shot 2D Circular/Elliptical OVS RF Pulses ...... 5083 Xiaoping Wu, Nate Powell, Malgorzata Marjanska, Michael Garwood, Kâmil Ugurbil, Pierre-François Van de Moortele

High Resolution Reduced-FOV Single-Shot FSE Imaging Using 2DRF Pulses with Less Blurring and Low SAR ...... 5084 Jing Yuan, Tzu-Cheng Chao, Yi Tang, Lawrence P. Panych

Selective Composite Adiabatic Refocusing Pulses for 3D RARE Imaging ...... 5085 Ziqi Sun

An On-The-Fly Radiofrequency Pulse for Bilateral Excitation with Independently Modulated Phase...... 5086 Ernesto Staroswiecki, John M. Pauly, Bruce Lewis Daniel, Brian Andrew Hargreaves

Multi-Frequency Parallel Transmit fopr Multi-Slice Scan Acceleration...... 5087 Laura Sacolick, Florian Wiesinger, Schulte F. Rolf, Dong Chen, Guido Kudielka, Wolfgang Loew,Mika W. Vogel

Counteracting RF Inhomogeneity on the Upper Legs at 3T Using Strongly Modulating Pulses...... 5088 Nicolas Boulant, Alexandre Vignaud, Pierre G. Carlier

RF Pulses for in Vivo Spectroscopy at High Field Designed Using Optimal Control...... 5089 Gerald B. Matson, Karl Young, Lana G. Kaiser

Electrodynamic Analysis of SAR and Transmit Homogeneity for RF Shimming on a Dielectric Cylinder...... 5090 Riccardo Lattanzi, Yudong Zhu, Daniel K. Sodickson

Slice-Selective Array-Optimized Composite Pulse for Simultaneous Improvement in Excitation Uniformity and Reduction of SAR ...... 5091 Bu Sik Park, Kyunghyun Sung, John McGarrity, Zhipeng Cao, Sukhoon Oh, Mark Watson, Scott Schilliak, Labros Petropolous, Christopher M. Collins

Experimental Estimation of Local SAR in a Multi-Transmit System...... 5092 Ulrich Katscher, Christian Findeklee, Tobias Voigt

Imaging Conductivity and Local SAR of the Human Brain...... 5093 Tobias Voigt, Olaf Doessel, Ulrich Katscher

A Novel Three Dimensional Radiofrequency Pulse for Small Voxel Excitation ...... 5094 Natee Ina, Suwit Saekho,

A Dual-Band Three-Dimensional Tailored RF Pulse for Simultaneous Susceptibility Artifact and B1+ Inhomogeneity Reduction...... 5095 Cungeng Yang, Weiran Deng, V. Andrew Stenger

Correction of Parallel Transmit RF Pulses at 9.4 T Using Measured Gradient Waveforms ...... 5096 Xiaoping Wu, J. Thomas Vaughan, Kâmil Ugurbil, Pierre-François Van de Moortele

An Efficiency Metric for k-Space Trajectories ...... 5097 Christopher J. Hardy, Luca Marinelli

Microstructural Assessment of Dental Tissues by Quantitative MRI Using Ultra-Short Echo Times (UTE): Initial In-Vivo Evaluation ...... 5098 Saïd Boujraf, Christian Hofmann, Johannes Ulrici, Erich Hell, Bernd Haller, Volker Rasche

In-Vitro Quantification of Dental Filling Induced Artifacts in Dental Magnetic Resonance Imaging Using Ultrashort Echo Time (UTE) at 3 Tesla...... 5099 Saïd Boujraf, Christian Hofmann, Regina Maschka, Johannes Ulrici, Erich Hell, Bernd Haller, Volker Rasche

Microstructural Assessment of Dental Tissues by Quantitative MRI Using Ultra-Short Echo Times (UTE): In- Vitro Evaluation ...... 5100 Saïd Boujraf, Christian Hofmann, Johannes Ulrici, Erich Hell, Bernd Haller, Volker Rasche

Imaging of Short T2 Species Using a Dual Adiabatic Inversion Recovery Ultrashort TE (DIR UTE) Sequence...... 5101 Jiang Du, Christine B. Chung, Mark Bydder, Won Bae, Atsushi M. Takahashi, Graeme M. Bydder

Improved Cardiac Shim Using Field Map Estimate from Multi-Echo Dixon Method ...... 5102 Peter Kellman, Diego Hernando, Saurabh Shah, Sven Zuehlsdorff, Andreas Greiser, Renate Jerecic

Fat Suppressed FSE Pelvic MR Imaging with Two New FSE Based Dixon Pulse Sequences: A Comparison of IDEAL FSE and FSE Triple Echo Dixon ...... 5103 Russell Norman Low, Neeraj Panchal,

Comparison of Susceptibility-Weighted Imaging and Magnetic Field Correlation Imaging ...... 5104 Caixia Hu, Jens H. Jensen, Kathleen Williams, Maria Fatima Falangola, Joseph A. Helpern

Fast, High Resolution T2 Mapping Using 3D MGE and 3D EPI, with 3D Correction for Macroscopic Dephasing Effects...... 5105 Simon Robinson, Markus Barth, Jorge Jovicich

Reference Phantom Validation of T2-Mapping: Maximum Likelihood Estimation of T2 from Magnitude Phased- Array Multi-Echo Data...... 5106 Clemens Bos, Adri Duijndam, Julien Sénégas

T1p -Weighted MRI Senses Partial Pressure of Oxygen...... 5107 Dharmesh R. Tailor, James E. Baumgardner, Walter R. T. Witschey, Ravinder Reddy

MR Contrast Generated by Altering Parameters of Adiabatic Pulses: Theoretical Simulations and in Vivo MRS Results...... 5108 Silvia Mangia, Timo Liimatainen, Michael Garwood, Pierre-Gilles Henry, Shalom Michaeli

Contrast Enhancement for Early Tumor Detection by Active Feedback Self-Nutation...... 5109 Sophia Y. Yang, Fang Liu, Dennis W. Hwang, Yung-Ya Lin

Intra and Inter-Site Reproducibility of Myelin Water Volume Fraction Values Derived Using mcDESPOT...... 5110 Sean CL Deoni, Rebecca Samson, Claudia A.M. Wheeler-Kingshot

Evaluation of k-t SENSE for Cardiac Imaging of Rats at 9.4T...... 5111 Anthony N. Price, Kenneth K. Cheung, Shaihan J. Malik, Mark F. Lythgoe

Preserving Signal Contrast in Multi-Slice Black Blood Fast Spin Echo ...... 5112 Ananth J. Madhuranthakam, Jesse L. Wei, Jean H. Brittain, Neil M. Rofsky, David C. Alsop

Comparison of Black Blood and Bright Blood Cardiac MR Imaging by Prospective- And Retrospective ‘wireless’ Gating Methods for Evaluation of Mouse Heart Function at 9.4T...... 5113 Sandra Margaretha Bovens, Bernard C. te Boekhorst, Meike van den Berk, Kees W. van de Kolk, Arno Nauerth, Niels Gadellaa, Marcel G. Nederhoff, Gerard Pasterkamp, Michiel ten Hove, Cees J. van Echteld

Optimization of Variable-Density Cartesian Sampling for Time-Resolved Imaging ...... 5114 Reed F. Busse, Kang Wang, James H. Holmes, Jean H. Brittain, Frank R. Korosec

A Low Curvature Uniformly Sampled Trajectory for 3D Imaging: The Interlocking Loops Trajectory...... 5115 Eric Wong

Shells with Integrated RadiaL and Spiral (SWIRLS): An Improved Shells k-Space Trajectory...... 5116 Yunhong Shu, Matt A. Bernstein

On Optimal Encoding of Flow in Three-Directional Phase-Contrast Sequences...... 5117 Francesco Santini, Michael Markl, Klaus Scheffler

Improved Radial Spoiled Gradient Echo Imaging with Randomized RF Phases and Gradient Moments ...... 5118 Wei Lin, Hee Kwon Song

Effects of Relaxation During RF Pulses on the Signal Intensity of Spoiled Gradient Echo Sequences...... 5119 Nicolas Boulant

Simultaneous Acquisition of Gradient Echo / Spin Echo BOLD and Perfusion with a Separate Labeling Coil...... 5120 Christopher Glielmi, Qin Xu, Richard Cameron Craddock, Xiaoping Hu

Recovery of Signal Loss Due to In-Plane Susceptibility Gradients in Gradient Echo EPI by Acquiring Extended Phase-Encoding Lines ...... 5121 Kwan-Jin Jung,

Field Map Measurements Using a TrueFISP Sequence...... 5122 Sven Zuehlsdorff, Peter J. Weale, Saurabh Shah, Andreas Greiser, Renate Jerecic

Simultaneous B1 and T1 Mapping Based on Modified "Actual Flip-Angle Imaging" ...... 5123 Tobias Voigt, Ulrich Katscher, Kay Nehrke, Olaf Doessel

Modulated Repetition Time Look Locker (MORTLL): a Method for Rapid High Resolution Three Dimensional T1 Mapping...... 5124 Neville Dali Gai, John Butman

A Multi-Spectral Three-Dimensional Acquisition Technique for Imaging Near Metal Implants ...... 5125 Kevin M. Koch, John E. Lorbiecki, R Scott Hinks, Kevin F. King

Phase Accrual During Excitation in Ultrashort TE (UTE) Imaging: an Alternate Definition of TE for Phase Measurements ...... 5126 Jing-Tzyh Alan Chiang, Michael Carl, Mark Bydder, Jiang Du, Robert F. Mattrey, Graeme Bydder

Assessment of Motion Sensitized Driven Equilibrium (MSDE) Improvement for Whole Brain Application...... 5127 Makoto Obara, Masatoshi Honda, Yutaka Imai, Marc Van Cauteren, Kagayaki Kuroda

Non-Contact Tracking of Involuntary Head Motions by Ultra-Wideband Radar for Improved High- And Ultra- High Field Magnetic Resonance Brain Imaging ...... 5128 Florian Thiel, Mathias Hein, Jürgen Sachs, Ulrich Schwarz, Tomasz Lindel, Frank Seifert

Non-Linear Effects at High-Speed Moving Table Imaging ...... 5129 Ulrich Katscher, Oliver Lips

SVD Eigenimage Based SENSE...... 5130 Yu Li, Feng Huang, Wei Lin, Charlie Saylor, Arne Reykowski

High Pass SENSE ...... 5131 Feng Huang, Yu Li, Wei Lin, Charlie Saylor, Arne Reykowski

An Unsupervised Method to Enhance Both SNR and Edges for PPI...... 5132 Weihong Guo, Feng Huang

GRAPPA Operator for Wider RadiaL Band (GROWL) ...... 5133 Wei Lin, Feng Huang, Yu Li, Charles Saylor, Arne Reykowski

Atlas Based Sparsification of Image and Theoretical Estimation (ABSINTHE) ...... 5134 Eric Pierre, Nicole Seiberlich, Stephen Yutzy, Jean Tkach, Mark Griswold,

Reconstruction Efficiency and Accuracy Improvement in Real Time Dynamic Parallel Imaging Through Explicit Tracking of Calibration Information...... 5135 Roger Nana, Xiaoping Hu

O-Space Imaging: Tailoring Encoding Gradients to Coil Profiles for Highly Accelerated Imaging...... 5136 Pelin Aksit Ciris, Jason Peter Stockmann, Lick-Kong Tam, Robert Todd Constable

Parallel Imaging Technique Using Localized Gradients (PatLoc) Reconstruction Using Orthogonal Mode Decomposition...... 5137 Fa-Hsuan Lin, Thomas Witzel, Jonanthan Polimeni, Juergen Hennig, Gerrit Schultz, John W. Belliveau, Lawrence L. Wald

Comparison of TSENSE, k-t SENSE and PINOT Fast Imaging Methods on Cine MRI...... 5138 Lei Hou Hamilton, Javier Acebrón Fabregat, David Moratal, Senthil Ramamurthy, Sebastian Kozerke, Marijn E. Brummer

Comparison of k-t-SENSE and k-t-GRAPPA Applied to Cardiac Cine and Phase Contrast Imaging...... 5139 Bernd André Jung, Sebastian Kozerke

Optimized Parallel Imaging for Dynamic PC-MRI with Multi-Directional Velocity Encoding ...... 5140 Hsu-Hsia Peng, Simon Bauer, Hsiao-Wen Chung, Juergen Hennig, Bernd Jung, Michael Markl

Extending GRAPPA Kernels to 4D: Application on Time-Resolved 3D Phase Contrast Imaging...... 5141 Bernd André Jung, Simon Bauer, Michael Markl

TV Regularization for High-Pass GRAPPA with Higher Net Acceleration Factor...... 5142 Xiaojing Ye, Yunmei Chen, Feng Huang

In-Vivo-Sensitivity-Based Regularization of Parallel MR Image Reconstruction...... 5143 Qi Duan, Ricardo Otazo, Jian Xu, Daniel K. Sodickson

In Vivo Receive Sensitivity Measurement ...... 5144 Jinghua Wang, Maolin Qiu, June Watzl, Robin de Graff, Robert Todd Constable

Updating Pre-Scan Sensitivity Maps with the Minimum Number of ACS Lines ...... 5145 Feng Huang, Yu Li, Wei Lin, Charlie Saylor, Arne Reykowski

Reconstruction of Retrospectively-Gated Cardiac Data Using a Combination of GRAPPA, SPACE-RIP, UNFOLD and an Adaptive Regularization Scheme ...... 5146 Tzu-Cheng Chao, William Scott Hoge, Jing Yuan, Hsiao-Wen Chung, Bruno Madore

High Spatial Frequencies Are More Dynamic Than Low Spatial Frequencies in Cardiac Motion...... 5147 Mireia Sanz Blasco, Sumati Krishnan, David Moratal, Senthil Ramamurthy, Marijn E. Brummer

Real-Time Shallow-Breathing Cardiac MRI Using Patient-Adaptive Parallel Imaging...... 5148 Behzad Sharif, John Andrew Derbyshire, Anthony Z. Farnesh, Robert J. Lederman, Yoram Bresler

An Auto-Calibrated k-t Approach for Fast 3D Dynamic Contrast-Enhanced Abdominal Imaging...... 5149 Peng Lai, Anja C. Brau, Philip J. Beatty, Shreyas Vasanawala, Manojkumar Saranathan

Accelerated Acquisition and Reconstruction of Non-CPMG Fast Spin Echo Sequences ...... 5150 Ken-Pin Hwang, Patrick Le Roux, Xiaoli Zhao, Zhiqiang Li

Spline-Based Variational Reconstruction of Variable Density Spiral k-Space Data with Automatic Parameter Adjustment...... 5151 Benedicte Delattre, Jean-Noël Hyacinthe, Jean-Paul Vallée, Dimitri Van De Ville

Spiral MR Reconstruction Using FOCUSS ...... 5152 Hisamoto Moriguchi, Yutaka Imai

Automatic Regularization for Magnetic Resonance Inverse Imaging...... 5153 Aapo Nummenmaa, Matti S. Hamalainen, Fa-Hsuan Lin

Optimal Combination and Filtering for 7 T – Phase Images ...... 5154 Shan Yang, Kai Zhong, John Grinstead, Oliver Speck

Improved Coil Combination for Homodyne-Corrected Phased Array Images ...... 5155 Ryan Fobel, Greg J. Stanisz

A Selective Acceleration and Multi-Resolution Approach to Multi-Echo Imaging...... 5156 Suchandrima Banerjee, Cornelius Von Morze, Douglas AC Kelley, Philip J. Beatty, Daniel B. Vigneron, Eric T. Han

Improved Visualization of the Subthalamic Nuclei by Reducing Susceptibility Induced Signal Losses in T2 Weighted Multi-Gradient-Echo Images...... 5157 Steffen Volz, Elke Hattingen, Christine Preibisch, Thomas Gasser, Ralf Deichmann

Effect of Reordering on Dynamic Contrast Enhancement ...... 5158 Vibhas Deshpande, Gabriel Acevedo-Bolton, Helmuth Schultze-Haakh, David Saloner, Gerhard Laub

Improved Image Quality by Noquist Acceleration of Cardiac MRI ...... 5159 Senthil Ramamurthy, David Moratal, James W. Parks, Stamatios Lerakis, Marijn E. Brummer

Comparison of Prospective ECG-Gated MRI with Wireless, Retrospective Gated MRI for Evaluation of Heart Function in Healthy and Infarcted Mouse Heart...... 5160 Sandra Margaretha Bovens, Bernard C. te Boekhorst, Krista den Ouden, Kees W. van de Kolk, Arno Nauerth, Marcel G. Nederhoff, Gerard Pasterkamp, Michiel ten Hove, Cees J. van Echteld

A Navigator Gated Free-Breathing FSE for Black Blood Cardiac Imaging ...... 5161 Liuquan Cheng, Yi Wang, Pascal Spincemaille, Thanh D. Nguyen, Qian Zhao, Na Yang

Recoverability Bounds for Parallel Compressive Sensing MRI...... 5162 Joshua D. Trzasko, Armando Manduca

Investigation of Sparsifying Transforms for Compressed Sensing in MRI Reconstruction...... 5163 Christopher Baker, Kevin King, Dong Liang, Leslie Ying

Sparse Image Reconstruction Using the Generalized Sampling Theorem for MR Angiography...... 5164 Nicole Seiberlich, Hyun Jeong, Timothy J. Carroll, Mark A. Griswold

Evaluation of Continuous Approximation Functions for the l0-Norm for Compressed Sensing ...... 5165 Carlos A. Sing-Long, Cristian A. Tejos, Pablo Irarrazaval,

Comparative Evaluation of L1 vs Lp Minimization Techniques for Compressed Sensing MRI...... 5166 Juan Carlos Ramirez Giraldo, Joshua D. Trzasko, Armando Manduca

Compressed Sensing Reconstruction Based on Maximum Intensity Projection Images ...... 5167 Dong-Hyun Kim, Sung-Min Gho

Compressed Sensing in Dynamic Enhanced Lung Imaging: A Comparison with k-t BLAST...... 5168 Jia-Shuo Hsu, Su-Chin Chiu, Tzu-Cheng Chao, Yi-Ru Lin, Hsiao-Wen Chung

Incorporating Self-Referenced Information Into Compressed Sensing in Dynamic Imaging...... 5169 Tzu-Cheng Chao, Bruno Madore, Ming-Long Wu, Jing Yuan, Hsiao-Wen Chung

Compressed Sensing for Active Feedback Contrast-Enhanced in Vivo Tumor Imaging ...... 5170 Luan Vu, Jon Furuyama, Thomas Goldstein, Stanley Osher, Yung-Ya Lin

Blade by Blade Compressed Sensing for PROPELLER...... 5171 Eric Aboussouan, Jim Pipe

Self-Adjusted Regularization Ratio for Robust Compressed Sensing...... 5172 Feng Huang, Yunmei Chen

Compressed Sensing for Motion Artifact Reduction...... 5173 Joelle Karine Barral, Dwight George Nishimura

Reconstruction of Magnetic Resonance Inverse Imaging Using the Minimum L-1 Norm Constraint...... 5174 Fa-Hsuan Lin, Thomas Witzel, Jonanthan Polimeni, John W. Belliveau

An Improved Approach in Applying Compressed Sensing in Parallel MR Imaging ...... 5175 Bing Wu, Richard Watts, Rick Millane, Philip Bones

A Novel Fast Dynamic Cardiac Data Reconstruction Method Using Prior Knowledge and Adaptive Matching Pursuits ...... 5176 Muhammad Usman, Philip G. Batchelor

HTGRAPPA: TGRAPPA Based B1-Weighted Image Domain Reconstruction for Real-Time MRI ...... 5177 Haris Saybasili, Peter Kellman, Mark A. Griswold, J. Andrew Derbyshire, Michael A. Guttman

A Real-Time Motion Compensation Package and Active Marker Headband for Brain MRI ...... 5178 Melvyn Boon King Ooi, Sascha Krueger, William J. Thomas, Srirama V. Swaminathan, Truman R. Brown

In-Vivo Applications of Optical Real-Time Motion Correction Using a Monovision System ...... 5179 Murat Aksoy, Matus Straka, Stefan Skare, Rexford Newbould, Samantha Holdsworth, Juan Santos,Roland Bammer

Image Instability Evaluation and Motion Correction for High-Resolution MRI of the Rat Retina...... 5180 Xiaodong Zhang, yingxia Li, Timothy Q. Duong

Rotation Correction with Self-Navigated MRI ...... 5181 Jason Mendes, Dennis L. Parker

A Kalman Filtering Framework for Prospective Motion Correction...... 5182 Julian Maclaren, Oliver Speck, Jürgen Hennig, Maxim Zaitsev

Reducing Artifacts in Dynamic MRI Movies Using a Spline Interpolated Sliding Window Technique ...... 5183 Eric Frederick, Iga Muradyan, Mirko Hrovat, Hiroto Hatabu, Samuel Patz

Pitfalls of Complex Summation and Its Variant Method in Synthesizing the Phase- Cycled SSFP Images to Suppress the Band Artifact ...... 5184 Kwan-Jin Jung,

Azimuthal Sorting in Tandem with Elliptical Reordering (ASTER): A New k-space Reordering Scheme for Reduced Motion Sensitivity...... 5185 Manojkumar Saranathan, Ersin Bayram, Ananth Madhuranthakam

In-Vivo Flow-Artifact Suppression Using Parallel Spatially Selective Excitation ...... 5186 Johannes Thomas Schneider, Martin Haas, Jürgen Hennig, Sven Junge, Wolfgang Ruhm, Peter Ullmann

Prospective Motion Correction with Stereoscopic Optical Tracking at 7T...... 5187 Daniel Stucht, Peter Schulze, Maxim Zaitsev, K. A. Danishad, Ilja Y. Kadashevich, Oliver Speck

The Effect of Magnetization Transfer on Rapid T2 Estimation with Phase-Cycled Variable Nutation SSFP...... 5188 Hendrikus Joseph Alphons Crooijmans, Klaus Scheffler, Oliver Bieri

Correction of Off-Resonance Effects in Multi-Component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT)...... 5189 Sean CL Deoni

A New Synthesis Method of Phase-Cycled SSFP Images to Remove the Band Artifact by Combining Complex Summation and Maximum Intensity Projection Techniques...... 5190 Kwan-Jin Jung,

19F/1H Simultaneous 3D Radial Imaging of Atherosclerotic Rabbits Using Self-Navigated Respiratory Motion Compensation...... 5191 Jürgen Rahmer, Jochen Keupp, Shelton D. Caruthers, Oliver Lips, Todd A. Williams, Samuel A. Wickline, Gregory M. Lanza

High Frame Rate Cardio-Respiratory Imaging Using Model-Based Reconstruction ...... 5192 Pierre-André Vuissoz, Freddy Odille, Brice Fernandez, Maelene Lohezic, Adnane Benhadid, Damien Mandry, Jacques Felblinger

On the Feasibility of Accelerating Self-Gated Cine Cardiac Imaging in Rodents Using SENSE ...... 5193 Christof Baltes, David Ratering, Markus Rudin,

Removal of Residual Motion Artifacts in fMRI Using Constrained Independent Component Analysis...... 5194 Kiran Kumar Pandey, Douglas C. Noll

Wii – Highly Sensitive Tracking of Patient Motion...... 5195 Olga Tymofiyeva, Michael Ledwig, Kurt Rottner, Ernst-Juergen Richter, Peter Michael Jakob

Prospective Head Movement Correction for High-Resolution MRI Using a Single Camera...... 5196 Lei Qin, Fenghua Jin, Yang Tao, Jeff H. Duyn

On the Application of Phase Correction and Use of k-Space Entropy in Partial Fourier Diffusion-Weighted EPI...... 5197 Samantha J. Holdsworth, Stefan Skare, Roland Bammer

Comparison of Physiological Trigger Modes for DWI in the Abdomen...... 5198 Tobias Binser, Harriet C. Thoeny, Chris Boesch, Peter Vermathen

Comparison of Quantitative Artifact Level in TGRAPPA and TSENSE Reconstruction During Deep Breathing ...... 5199 Mihaela Jekic, Yu Ding, Yiu-Cho Chung, Subha V. Raman, Jennifer Dickerson, Sven Zuehlsdorff, Sonia Nielles-Vallespin

Respiratory Navigation Scheme for Free-Breathing 3D SPGR Liver Imaging: Technical Feasibility ...... 5200 A. C. Brau, Y. Iwadate, E. Bayram, P. M. Young, S. Vasanawala, R. J. Herfkens

Simple Method for Free-Breathing Multi-Slice T2w-TSE Liver Imaging Without PACE ...... 5201 Sang-Young Zho, Jaeseok Park, Dong-Hyun Kim

3-D Prospective Motion Correction for MR Spectroscopy...... 5202 Brian Keating, J C. Roddey, Weiran Deng, Anders Dale, Nathan White, V Andrew Stenger, Thomas Ernst

Real-Time Prospective Rigid-Body Motion Correction with the EndoScout Gradient-Based Tracking System ...... 5203 Andre Jan Willem van der Kouwe, Barry Fetics, Dmitry Polenur, Abraham Roth, Erez Nevo

Real-Time Optical Motion Correction for Diffusion Tensor Imaging ...... 5204 Murat Aksoy, Matus Straka, Stefan Skare, Rexford Newbould, Samantha Holdsworth, Juan Santos, Roland Bammer

Variable Sampling Density Spherical Navigator Echoes (VSD SNAV) for Prospective 3D Alignment ...... 5205 Junmin Liu, Maria Drangova

Self-Navigator for Free-Breathing 3D SSFP Cardiac Imaging: Center of Mass Along the Slice Direction Versus the Image Signal Sum Using the Center of k-Space...... 5206 Pascal Spincemaille, Jing Liu, Thanh Dang Nguyen, Martin Prince, Yi Wang

Practicality Makes a Comeback: Dynamic MRI Without the Overhead...... 5207 Uygar Sümbül, John Mark Pauly

Computational Model of the Left Ventricle Motion Using Tagged Magnetic Resonance Imaging (tMRI)...... 5208 Mohammed Dahawy Alenezy, Tareq M. Alrefae, Jack Shi, Mehmet Bigen

Free Breathing Black-Blood Systolic Imaging Using Heart Rate Prediction and Motion Compensated Reconstruction ...... 5209 Maelene Lohezic, Brice Fernandez, Julien Oster, Damien Mandry, Olivier Pietquin, Pierre-Andre Vuissoz, Jacques Felblinger

3-D Multi-Coil Motion Correction for Spiral Projection Imaging ...... 5210 Kenneth O. Johnson, Eric Aboussouan, James G. Pipe

Quantitative Evaluation and Optimization of 3D PROspective MOtion (PROMO) Through Offline Simulation...... 5211 Jian Zhang, Daniel Rettmann, Eric Han, Cooper Roddey, Nate White, Joshua Kuperman, Juan Santos, Anders Dale, Ajit Shankaranarayanan

Geometric Distortion Correction in Echo Volumar Imaging...... 5212 Wenlong Qian, Paul M. Glover, Richard W. Bowtell

Evaluation of EPI Geometric Distortion Correction Using Phase Labeling for Additional Coordinate Encoding (PLACE) ...... 5213 Sheeba Arnold, Markus Vogler, Oliver Hinds, Susan Whitfield-Gabrieli, Michael Hamm, Josef Pfeuffer, Christina Triantafyllou

Compensation of Respiration-Induced Off-Resonance in Real-Time Spiral k-t BLAST Imaging ...... 5214 Holger Eggers

Free-Breathing Dynamic Magnetic Resonance Imaging of the Abdomen...... 5215 Frederik J. de Bruijn, Yan Zhang, André M. Sprengers, Aart J. Nederveen, Jaap Stoker, Rolf M. Lamerichs

Improved R2 Measurement Accuracy with Absolute SNR Truncation and Optimal Coil Combination...... 5216 Xiaoming Yin, Saurabh Shah, Peter Kellman, Andrew C. Larson

A General Method for Correction of Intensity Inhomogeniety in Two Point Dixon Imaging...... 5217 Ola Friman, Olof Dahlqvst Leinhard, Peter Lundberg, Magnus Borga

Scanner Calibration for Multisite Geometric Accuracy: How to Do It ...... 5218 Berkay Kanberoglu, Ted Trouard, Lina Karam, Josef P. Debbins

PET Effects on MR Data Quality in an Integrated MR-PET Human Brain Scanner ...... 5219 Thomas Benner, Andre J. W. van der Kouwe, Ciprian Catana, Michael Hamm, A. Gregory Sorensen, Bruce R. Rosen

Motion Induced Magnetic Susceptibility and Field Map Estimation in fMRI...... 5220 Desmond Yeo, Jeffery Fessler, Boklye Kim

Performance of Stereo Vision and Retro-Grate Reflector Motion Tracking Systems in the Space Constraints of an MR Scanner...... 5221 Brian Armstrong, Brian Andrews-Shigaki, Robert T. Barrows, Todd P. Kusik, Thomas Ernst, Oliver Speck

Combine Reconstructions Using Non-Local Operator and Its Application in PPI...... 5222 Weihong Guo, Hu Cheng, Feng Huang

Retrospective Self-Navigated Cine Imaging Using the Unused Echo in Alternating TR SSFP...... 5223 Hsu-Lei Lee, Ajit Shankaranarayanan, Krishna S. Nayak,

Cardiac and Respiratory Motion Compensated Reconstruction Driven Only by 1D Navigators ...... 5224 Freddy Odille, Sergio Uribe, Tobias Schaeffter, David Atkinson

Real-Time Adaptive Motion Correction for Coronary MR Angiography...... 5225 Markus Henningsson, Sergio A. Uribe Arancibia, Andrea J. Wiethoff, Philip G. Batchelor, Rene M. Botnar

Real-Time Motion Corrected MRS Using EPI Navigators...... 5226 Aaron T. Hess, Matthew Dylan Tisdall, Ernesta M. Meintjes, Andre J. W. van der Kouwe,

Phase Based Navigator Echo Analysis with a Virtual Large Loop RF Coil ...... 5227 Yuji Iwadate, Kenichi Kanda, Akira Nabetani, Tetsuji Tsukamoto

The Effects of Induced B0 and B1 Magnetic Field Perturbations on Efforts to Image Near Embedded Metal Hardware...... 5228 Kevin M. Koch, Kevin F. King, Graeme C. McKinnon

Quantitative Evaluation of Metal Artifact with New Turbo Spin Echo Imaging Techniques...... 5229 Chen Lin, Brian Dale, Larry Friggle, Leverett Neville, Annette Douglas-Akinwande, Kenneth Buckwalter

Rigid Body Motion Detection with Lissajous Navigator Echoes...... 5230 Marcus G. Ullisch, Tony Stöcker, Mark A. Elliott, Kaveh Vahedipour, N. Jon Shah

Noise Bias Correction for Signal Averaged Images...... 5231 Elena Olariu, Arturo Cardenas-Blanco, Ian Cameron

PARAMAP: An Automated Imaging Analysis Tool for Quantitative CEST Molecular Imaging: Validation in Vitro ...... 5232 Julien Flament, Benjamin Marty, Sébastien Mériaux, Julien Valette, Christelle Medina, Caroline Robic, Marc Port, Franck Lethimonnier, Fawzi Boumezbeur

Rapid Motion Detection Using Pre-Rotated Baseline Spherical Navigator Echoes...... 5233 Junmin Liu, Maria Drangova

Increasing the Effectiveness of the UNFOLD Technique by Removing Phase Trends ...... 5234 Yanle Hu

TV Regularization for Segmented GRAPPA with Higher Net Acceleration Factor ...... 5235 Yunmei Chen, Xiaojing Ye, Haili Zhang, Jiangli Shi, Feng Huang

MPRAGE Using EPI Navigators for Prospective Motion Correction ...... 5236 Matthew Dylan Tisdall, Aaron Hess, Andre van der Kouwe

Iterative Image Reconstruction for PROPELLER-MRI: Through-Plane Motion Considerations...... 5237 Ashish A. Tamhane, Mark Anastasio, Konstantinos Arfanakis

Correction for Chemical Shift Artifacts in Magnetic Resonance Electrical Impedance Tomography ...... 5238 Mark Jason Hamamura, Orhan Nalcioglu, Lufti Tugan Muftuler

DCE-MRI Tumor Registration by Using TV-L1 Optical Flow...... 5239 Michael Hofer, Thomas Pock, Karin Kapp, Thomas Bauernhofer, Franz Ebner, Rudolf Stollberger

Self-Navigated IDEAL Water-Fat Separation ...... 5240 Yun Jiang, Jeffrey Tsao

Impact of B1 Inhomogeneities on AIF Selection in DCE-MRI at 3 Tesla...... 5241 Robert Merwa, Gernot Reishofer, Thorsten Feiweier, Karin Kapp, Franz Ebner, Rudolf Stollberger

Morphometry of Intratumoral Enhancement Patterns on 4D Spectral Images for Differential Diagnosis of Breast Tumors in Dynamic Contrast-Enhanced MRI...... 5242 Sang Ho Lee, Jong Hyo Kim, In Chan Song, Yun Sub Jung, Jeong Seon Park, Woo Kyung Moon

Application of Vessel Exclusion for Development of Computer-Aided Diagnosis for Breast MRI ...... 5243 Muqing Lin, Ke Nie, Jeon-Hor Chen, Orhan Nalcioglu, Min-Ying Lydia Su

Association of Carotid Atherosclerosis Eccentricity with High Risk Plaque Features: An MRI Study ...... 5244 Huijun Chen, Li Dong, William S. Kerwin, Wei Yu, Hideki Ota, Hunter Underhill, Xihai Zhao,Zhaoqi Zhang, Zach Miller, Thomas S. Hatsukami, Chun Yuan

Depiction of SPIO in Atherosclerotic Plaque Using True Resolution SGM ...... 5245 Gopal Varma, Marcus Richard Makowski, Hannes Dahnke, Stephen Keevil, Rene M. Botnar, Tobias Schaeffter

A MRI-Based Virtual Cystoscopy System for Evaluation of the Entire Bladder ...... 5246 Jerome Zhengrong Liang, Lihong Li, Chaijie Duan, Su Wang, Mark Wagshul, Hongbing Lu

Deconvolution and QSI of Simulated Phase Images of the Human Brain: Applications to Assess Susceptibility ...... 5247 Guenther Grabner, Siegfried Trattnig, Markus Barth

Simulation of Nasal Air Flow from MRI Data – a Feasibility Study...... 5248 Arthur Peter Wunderlich, Barbara Doll, Marc Scheithauer, Wolfgang Freund, Karsten Urban, Ulrich Simon

MR Elastography Inversions Without Phase Unwrapping ...... 5249 Kevin John Glaser, Richard Lorne Ehman

A Model-Based Fully Automatic Algorithm for Brain Extraction on 3D MRI Scans...... 5250 Babak A. Ardekani, Alvin H. Bachman

A Robust Parametric Method for Bias Field Estimation and Segmentation of MR Images ...... 5251 Chunming Li, Li Wang, J. Chris Gatenby, Adam Anderson, John C. Gore

Template-Based Bias Correction: Application to Paediatric Brain MRI ...... 5252 Maria Murgasova, Joseph V. Hajnal, Serena J. Counsell, A David Edwards, Daniel Rueckert

Artificial Neural Network Analysis of Differences in Fiber Tracks Between Term and Preterm Children...... 5253 Lutfi Tugan Muftuler, Ke Nie, Orhan Nalcioglu, Christine E. McLaren, Min Ying Su

High Resolution Positive Contrast Imaging: Application to the Visualization of Localized Vascular Abnormalities ...... 5254 Thomas G. Perkins, Julien Sénégas, Hannes Dahnke, Elliot Sandberg, William W. Orrison

Rapid Quantification of Stroke Infarct from Diffusion Weighted Images ...... 5255 Sumit K. Nath, Rakesh Mullick, Dattesh Shanbhag, Uday Patil

Noise Performance of IDEAL Considering Relaxation and Multiple Spectral Peaks of Fat...... 5256 Stephan van Zyl, Peter Börnert, Holger Eggers, Michael M. Morlock

Efficient and Effective Anisotropic Smoothing of Diffusion Tensor Images in Log-Euclidean Framework...... 5257 Qing Xu, Adam W. Anderson, John C. Gore, Zhaohua Ding

Leveraging Open Source/Freeware Tools and Design Methodologies in Translational Research: A Siemens-Based Case Study -- From Raw Diffusion and Structural Data to PACS and the Web ...... 5258 Rudolph Pienaar, Ruopeng Wang, Bruce Fischl, Van Wedeen, Patricia Ellen Grant

NeuroGrid Portal: A Web Interface Providing Processing Tools for Neuro-Imaging Research...... 5259 Ali A. Khanban, Yu Chen, Gianlorenzo Fagiolo, Nick C. Fox, Derek L. G Hill, Daniel Rueckert, Jo V. Hajnal

High Dynamic Range Processing Improves Global Contrast...... 5260 Jerod Michael Rasmussen, Vinod Kaimal

Consistency in Automated Versus Manual Definition of MRI Scan Volume Orientations of the Human Heart ...... 5261 Harald Sepp Heese, Sebastian P. M. Dries, Daniel Bystrov, Jochen Peters, Olivier Ecabert, Juergen Weese, Chiel J. den Harder, Wendy de Kok, Arianne M. van Muiswinkel

Simultaneous Mapping of Functional Connectivity and Activation Using Real-Time fMRI ...... 5262 Dae-Jin Kim, Bumhee Park, Hae-Jeong Park

Simple Subject-Specific Spatial Smoothing for BOLD fMRI...... 5263 Robert L. Barry, John A. Sexton, John C. Gore,

Evaluation of the Image Intensity Non-Uniformity Correction Power in Voxel-Based Morphometry...... 5264 Masami Goto, Osamu Abe, Tosiaki Miyati, Hiroyuki Kabasawa, Takeshi Iwatsubo, Hiroshi Matsuda,Fumio Yamashita, Shigeki Aoki, Harushi Mori, Naoto Hayashi, Kenji Ino, Keiichi Yano, Kyouhito Iida, Kazuo Mima, Kuni Ohtomo

Effects of the Modulation in the White Matter Voxel Based Morphometry ...... 5265 Ozlem Ozmen Okur, Cengizhan Ozturk, Kubilay Aydin

A Robust Breast Segmentation Method to Support Computer Aided Evaluation and Breast Density Assessment...... 5266 Gokhan Ertas, Martin O. Leach

Development of a Computer Algorithm-Based Method for Identification of Blood Vessels on Dynamic Contrast Enhanced Breast MRI...... 5267 Muqing Lin, Jeon-Hor Chen, Ke Nie, Orhan Nalcioglu, Min-Ying Lydia Su

Design of an MR Phantom for Comparison of Frequency Based Texture Analysis Techniques...... 5268 Robert Allan Brown, Richard Frayne

Demonstration of a Novel Edge Analysis Technique Using a Purpose Built MR Phantom...... 5269 Robert Allan Brown, Ashley D. Harris, Richard Frayne

Automatic Quality Assessment in Structural Brain Magnetic Resonance Imaging ...... 5270 Bénédicte Mortamet, Matt A. Bernstein, Clifford R. Jack Jr, Jeffrey L. Gunter, Chadwick Ward, Paula J. Britson, Reto Meuli, Jean- Philippe Thiran, Gunnar Krueger

Simultaneous Identification of Noise and Estimation of Noise Standard Deviation in MRI ...... 5271 Cheng Guan Koay, Evren Özarslan, Carlo Pierpaoli

A Framework for Correcting the Noise-Induced Bias in Noisy Magnitude MR Signals ...... 5272 Cheng Guan Koay, Evren Özarslan, Peter J. Basser

Characterization of Image Heterogeneity Using Minkowski Functionals ...... 5273 Holly C. Canuto, Mikko I. Kettunen, Charles I. McLachlan, Anant S. Krishnan, Andre' A. Neves,De-en Hu, Michael P. Hobson, Kevin M. Brindle

Landmark-Based Prostate MR Image Matching Using Incompressible Large Deformation Diffeomorphism...... 5274 Xiaofeng Liu, Steven Roys, Jerry L. Prince, Rao Gullapalli

Non-Rigid Registration of T1 MR Images Constrained with Fractional Anisotropic (FA) Maps ...... 5275 Xia Li, Benoit Dawant, Xin Hong, Zhaohua Ding, John Gore, Adam Anderson

Metrics for Quantifying the Quality of MR Images ...... 5276 Francisco Prieto, Marcelo Guarini, Cristian Tejos, Pablo Irarrazaval

Improved Visualization of Iron-Rich Structures in the Brain with 3D Multiecho GRE Imaging ...... 5277 Yunhong Shu, Matt A. Bernstein, Marsha Swatosh, John Huston, Kiaran P. McGee, Kendall H. Lee

Use of Multi-Spectral MR Data to Generate an Attenuation Map for Application to PET/MR Hybrid Imaging...... 5278 Harry Robert Marshall, Robert Z. Stodilka, Benoit Lewden, Jean Theberge, Eric Sabondjian, Alexandre Legros, Andrea Mitchell, Lela Dorrington, Jane Sykes, Frank S. Prato

Navigator Filtering Using Principle Component Analysis...... 5279 Sergio Andres Uribe Arancibia, Philipp Batchelor, Claudia Prieto, Reza Razavi, Tobias Schaeffter

Augmenting Surgery Planning for Neoadjuvant Chemotherapy Patients by 3D Transformation of Prone Breast MR Images to the Supine Images in the Operating Room Setting ...... 5280 Ruparani Chittineni, Jeon-Hor Chen, Orhan Nalcioglu, Min-Ying Su

Implicit Reference-Based Group Registration in Structural and Functional MRI Studies...... 5281 Xiujuan Geng, Hong Gu, Thomas J. Ross, Yihong Yang

Effects of Patient Population Specific Atlases on Automatic Segmentation of Subcortical Structures in Freesurfer...... 5282 Istvan Csapo, Jared Price, Troy Russell, Jeff Dewey, Ekta Sem, Daniel McCaffrey, Charles R.Guttmann, Bradford Navia, David F. Tate

A Simple Semi-Automated Method for Caudate Volume and Shape Analysis...... 5283 Karlene M. Fraser, Mitul A. Mehta, Ruth L. O'Gorman,

Automatic Segmentation of Deep Grey Matter Structures for the Assessment of DTI Images ...... 5284 Emil Malucelli, David Neil Manners, Claudia Testa, Caterina Tonon, Giovanni Rizzo, Valerio Carelli,Giuseppe Nicoletti, Aldo Quattrone, Bruno Barbiroli, Raffaele Lodi

Reliability and Validity of MRI-Based Automated Volumetry Software Relative to Manual Measurement of Subcortical Structures in HIV-Infected Patients from a Multisite Prospective Study...... 5285 Jeffrey Dewey, George Han, Troy Russell, Jared Price, Daniel McCaffrey, Ekta Sem, Joy Chinazom Anyanwu, Charles Guttmann, Bradford Navia, Ronald Cohen, David Tate

Calculation of Optic Nerve Dimensions Using Gaussian Fitting of MR Images ...... 5286 Li Sze Chow, Lauren Wallis, Nigel Hoggard, Simon J. Hickman, Martyn N.J. Paley

Multilevel Segmentation and Classication of MS Lesions ...... 5287 Alvina Goh, Christophe Lenglet, Mariappan Nadar

Computer-Aided GBM Tumor ROI Contouring and Mapping Framework for Structural and Physiological MR Images in a Multi-Center Clinical Trial...... 5288 Jing Huo, Matthew S. Brown, Jeffry R. Alger, Whitney B. Pope, Hyun J. Kim, Jonathan G. Goldin

Model Error Maps as Robust Features for T1/T2-Weighted Data Segmentation ...... 5289 Umesh Suryanarayana Rudrapatna, Annette van der Toorn, Ivo A. Tiebosch, Josien P.W Pluim, Rick M. Dijkhuizen

Motion Correction for Perfusion Weighted Images in Stroke: Approach and Impact on Quantification ...... 5290 Rakesh Mullick, Dattesh Shanbhag, Uday Patil, Xiaodong Tao

Model-Based Automatic Detection of the Anterior and Posterior Commissures on MRI Scans ...... 5291 Babak A. Ardekani, Alvin H. Bachman

MARM: Multiscale Adaptive Regression Models for Neuroimaging Data ...... 5292 Yimei Li, Hongtu Zhu, Dinggang Shen, Songyuan Tang, Weili Lin

Statistic Model of Respiratory Motion by Using Dynamic MRI...... 5293 Gang Gao, Jamie McClelland, Dave Hawkes

Automatic Macro-Vessel-Minimization Using Independent Component Analysis and Local Scaling Functions...... 5294 Gernot Reishofer, Stephen Keeling, Robert Merwa, Christian Enzinger, Stefan Ropele, Rudolf Stollberger, Franz Ebner

Hemodynamic Characterization of the Trans-Thoracic Circulation by Contrast-Enhanced Magnetic Resonance Imaging ...... 5295 Massimo Mischi, Harrie CM van den Bosch, Jacques A. den Boer, Jan Verwoerd, Rene JE Grouls,Hendrikus HM Korsten

Volume Tracking - A Novel Method for Visualization and Quantification of Cardiac Blood Flow...... 5296 Johannes Töger, Håkan Arheden, Gustaf Söderlind, Einar Heiberg

Estimation of Left Ventricle Parameters from Cine MR Data: Fully Automatic Versus Manual Analysis...... 5297 Thomas Ki-Yong Broussaud, Alain Nchimi

In Vivo Cardiac NMR Diffusion Weighted Imaging(DWI) for the Human Heart: Tackling Motion Issue with Temporal Maximum Intensity Projection(tMIP)-DWI and First Results in Humans ...... 5298 Stanislas Rapacchi, Pierre Croisille, Magalie Viallon, Denis Grenier, Peter Kellman, Han Wen

Adaptive Trigger Delay Using a Predictive Model Applied to Black Blood Fast Spin Echo Cardiac Imaging in Systole ...... 5299 Brice Fernandez, Julien Oster, Maelene Lohezic, Damien Mandry, Olivier Pietquin, Pierre-André Vuissoz, Jacques Felblinger

Doubled Scan Efficiency in Multi-Slice Real-Time Cine TrueFISP Cardiac Imagingby Pseudo-Continuous Sliding Slice Acquisition...... 5300 Andreas Greiser, Sven Zuehlsdorff, Edgar Mueller

3D Dynamic Contrast-Enhanced Using Undersampled Golden-Radial Phase Encoding...... 5301 Claudia Prieto, Sergio Uribe, Reza Razavi, David Atkinson, Philipp Beerbaum, Tobias Schaeffter

Time-Resolved Contrast-Enhanced Radial Ghost MRA ...... 5302 Hyun Jong Jeong, Ioannis Koktzoglou, Christopher S. Eddleman, John Sheehan, James Carr, Timothy John Carroll, Robert Edelman

Time-Resolved MRA Using Radial Multi-Echo Sequence and Sliding Window Reconstruction ...... 5303 Hyun Jong Jeong, Saurabh Shah, Christopher S. Eddleman, John Sheehan, James Carr, Timothy John Carroll

Fast Imaging Sequence for Free-Breathing Planning in Cardiac Imaging...... 5304 Tamer A. Basha, Monda L. Shehata, Nael F. Osman

T2 Weighted Preparation with Selective Response: Contrast Mechanism for Dark Blood Imaging and Arterial- Venous Discrimination...... 5305 Peter Kellman, Anthony Z. Faranesh, J. Andrew Derbyshire, Logi Vidarsson

Comparison of Large Phased Arrays Using Stacked Segments...... 5306 Wolfgang Driesel, André Pampel, Toralf Mildner, Stefan Hetzer, Harald E. Möller

Multi Arm Archimedean Coil for High Field MRI ...... 5307 Sofia Sanchez, Silvia Sandra Hidalgo, Sergio Enrique Solis, Mario Rosas, Alfredo Odon Rodriguez

Noise Figure Limits for Circular Loop MR Coils...... 5308 Ananda Kumar, William Alan Edelstein, Paul Arthur Bottomley

A High Temperature Superconducting (HTS) Coil for Imaging of Human Extremities...... 5309 Hoon-Sin Cheong, Ivo Volkov, Neil Alford, Chris Randell, Jim Wild, Martyn Paley

Hybrid Decoupling for RF Coils...... 5310 Dashen Chu, Ricardo Matias, Scott Lindsay,Robert Stormont, Eddy Boskamk, Saban Kurucay

Model-Based MRI Coil Tuning Algorithm...... 5311 Liang Liu, Charles Bouman, Thomas Talavage, Victor Taracila, YunJeong Stickle, Limin Feng, Pei H Chan, Fraser Robb

Frequency Division Multiplex for Phased Array Receive Coils...... 5312 Joseph Iannotti, Steven Go, Kevin Dufel, Bill Platt, Eric Fiveland

Coil Performance vs. Preamplifier Location in the MR Phased Array...... 5313 Randy O. Giaquinto, Joseph E. Piel

A High Throughput 8 Channel Mouse Probehead for 9.4 T ...... 5314 Titus Lanz, Matthias Müller, Hannah Barnes, Jürgen E. Schneider

A 16-Channel Rat-Body Array Coil with an Integrated Birdcage Transmitter at 7T ...... 5315 Martin Tabbert, Marco Motz, Marcos Lopez, Erhard Pfrommer, Sven Junge

An Array RF Coil for Rabbit Thoracic Arteries Imaging at 200MHz...... 5316 Raimo PJ Joensuu

A Four Channel SENSE Microcoil Array with Integrated Physiology Support System for Imaging Four Mouse Brains...... 5317 Marcelino Bernardo, Peter Choyke

A Semi-Flexible 32-Ch RF Coil Array for Clinical 3T Brain Imaging...... 5318 Yu Li, Matthias Gyori, KD McClellan, Charlie Saylor, Arne Reykowski

An Improved 28 Channel Coil Array for Optic Nerve Imaging ...... 5319 Robb Merrill, J. Rock Hadley, Emilee Minalga, Dennis Parker, Sathya Vijayakumar, Seong-Eun Kim Choi, Laura Bell, John Rose,

Coil System for Optimal MR Mammography and MR-Guided Intervention...... 5320 Bernadette Marie Kaufman, Yoshinori Hamamura, Ashok Menon, Jovan Jevtic

Simplified RF Modeling of Coil Arrays Composed of Cylindrically Arranged Modules ...... 5321 Andre Pampel, Wolfgang Driesel, Harald E. Moeller

SNR Benefits of Surface Coil Lift-Off at High Magnetic Field Strength ...... 5322 Qi Duan, Graham Wiggins, Bei Zhang, Riccardo Lattanzi, Bernd Stoeckel, Daniel K. Sodickson

A Novel Metamaterial Transmit/receive Coil Element for 7 T MRI – Design and Numerical Results...... 5323 Jochen Mosig, Achim Bahr, Thomas Bolz, Mark E. Ladd

Improving SNR and RF by Adding a Stripline to Endorectal Coil for the 7T...... 5324 Catalina S. Arteaga, Bob van den Bergen, Peter L. Luijten, Uulke A. van der Heide, Dennis W.J. Klomp

Trap Design Performance for RF Coils for Dual-Frequency MRI & MRS ...... 5325 Arash Dabirzadeh, Mary Preston McDougall

Design of a Patch Antenna for Creating Traveling Waves at 7 Tesla ...... 5326 Bei Zhang, Graham Wiggins, Qi Duan, Daniel K. Sodickson

Low Eddy Current RF Body Coils ...... 5327 Ed Boskamp, Bijay Shah, Ken Rohling, Anton Linz

Litz Wire Radiofrequency Coils for Hyperpolarized Noble Gas Imaging of Rodent Lungs at 74 mT...... 5328 William Dominguez Viqueira, Warren Berger, Juan Parra-Robles, Giles E. Santyr

A Numerical Comparison of Conservative E-Field Shield Designs in a Solenoidal Coil ...... 5329 Bu Sik Park, Andrew G. Webb, Christopher M. Collins,

Magnetron Volume Coil for Magnetic Resonance Imaging of Rodents...... 5330 Jaime Fabian Vazquez, Oscar Rene Marrufo, Sergio Enrique Solis, Silvia Sandra Hidalgo, Alfredo Odon Rodriguez

A Novel 4 T Double Tuned (1H-23Na) Surface Tem Resonator ...... 5331 Assunta Vitacolonna, Sandro Romanzetti, Nadim Jon Shah, Marcello Alecci

A Simplified Procedure for Remote Tuning Local MRI Coils for Maximum Signal-To-Noise Ratio...... 5332 William J. O'Reilly, Paul K. Jackson, Andrzej Jesmanowicz

Counter Rotating Current Coil for 3-D Eye Growth Study of Infant Rhesus Monkeys...... 5333 Flora S. Ip, Jenny Huang, Kurt H. Bockhorst, Kishore Mogatadakala, Terry L. Blasdel, Ponnada A. Narayana, Earl L. Smith III, Jarek Wosik

Low E-Field and Low Acoustic Birdcage Coil Design...... 5334 Saikat Saha

Reduced Sample Heating in High Field Micro-MRI Using a Copper Wire Shield: Experimental and Numerical Results...... 5335 Bu Sik Park, Thomas Neuberger, Andrew G. Webb, Don C. Bigler, Christopher M. Collins

Validation of Electromagnetic Field Simulation for MR Coil Design at 3 Tesla...... 5336 Wolfgang Loew, Georg Strauss, Mika W. Vogel

Slotted End-Ring Volume Coil for Small Animal Magnetic Resonance Imaging at 7T...... 5337 Oscar Rene Marrufo, Sergio Enrique Solis, Silvia Sandra Hidalgo, Alfredo O. Rodriguez

Comparison of Coil Realisations for Applications Employing Parallel Excitation...... 5338 Jörg Felder, Sandro Romanzetti, Marcello Alecci, N. Jon Shah

Alternating Impedance Element for 7T Multi-Channel Transceive Coil ...... 5339 Can Akgun, Lance DelaBarre, Carl J. Snyder, Jinfeng Tian, Anand Gopinath, Kamil Ugurbil, John Thomas Vaughan

Shielded Microstrip Head Array at 7T ...... 5340 Bing Wu, Chunsheng Wang, Douglas Kelley, Duan Xu, Daniel Vigneron, Sarah Nelson, Xiaoliang Zhang

Using Separated Volume Transmit and Local Receiver Arrays for Body Imaging at 7T ...... 5341 Carl Jason Snyder, Lance DelaBarre, Jinfeng Tian, Can Akgun, Greg Metzger, Steen Moeller, Kamil Ugurbil, J. Thomas Vaughan

An 8-Channel Rat-Body Array Coil for Transceive at 9.4T...... 5342 Martin Tabbert, Daniela Schinko, Johannes Schneider, Peter Ullmann, Hans Post, Sven Junge

Calibration of Transceive-Array RF Power Using Lanthanide Shift Agents...... 5343 Andrew T. Curtis, Ravi S. Menon

+ Boosting B1 Efficiency for RF Transmit Surface Elements by a Radiative Antenna Design ...... 5344 Alexander J. Raaijmakers, Jan J. W. Lagendijk, Dennis W. Klomp, Bob van den Bergen, Cecilia Possanzini, Paul R. Harvey, Cornelis A. van den Berg

Performance Optimization of a Multi-Channel Transmit Coil with Significant Coupling Between Elements...... 5345 Mikhail Kozlov, Robert Turner

Current Controlled Transmit/Receive Elements in Parallel Excitation and Parallel Imaging ...... 5346 Evgeniya Kirilina, André Kuehne, Tomasz Lindel, Werner Hoffmann, Thomas Riemer, Frank Seifert

An 8-Channel Add-On RF Shimming System for Whole-Body 7 Tesla MRI Including Real-Time SAR Monitoring...... 5347 Andreas Klaus Bitz, Irina Brote, Stephan Orzada, Oliver Kraff, Stefan Maderwald, Harald H. Quick, Pedram Yazdanbakhsh, Klaus Solbach, Achim Bahr, Thomas Bolz, Karsten Wicklow, Franz Schmitt, Mark E. Ladd,

16-Bit Vector Modulator for B1 Shimming in 7T MRI...... 5348 Pedram Yazdanbakhsh, Sebastian Held, Irina Brote, Andreas Bitz, Stephan Orzada, Mark E. Ladd,Klaus Solbach

High-Bandwidth, High-Efficiency RF Amplitude Modulation for On-Board Transmit Amplifiers...... 5349 Natalia Gudino, Jeremiah A. Heilman, Mark A. Griswold

Reconfigurable Electronic Tune-Detune Circuit for RF Coil Systems ...... 5350 Peter Serano, Mathew Brevard, William Nastri, Reinhold Ludwig

A 32 Channel RF Array and Integrated Gradient Insert ...... 5351 Martyn NJ Paley, James Paley, Ian Young

Bo Anchored Spatial Excitation (BASE) for Effective Fat Suppression Under Bo Inhomogeneity: Implication for Parallel Transmission...... 5352 Allen W. Song, Nan-Kuei Chen, Brian Soher

Transmit SENSE with Measured and Simulated B1+ Fields ...... 5353 Yik-Kiong Hue, Tiejun Zhao, Hai Zheng, Yongxian Qian, Fernando E. Boada, Tamer S. Ibrahim

SAR and Temperature Evaluations for B1 Shimming at 7 Tesla ...... 5354 Lin Tang, Tamer S. Ibrahim

Comparing SAR Calculated in Multiple Human Body Models at 1.5T ...... 5355 Zhangwei Wang, Christopher M. Collins, Jason Jin, Victor Taracila, Qing X. Yang, Fraser J. Robb

Fast E1, B1 and SAR Simulation with the Use of Graphics Processors...... 5356 Lohith Kini, Larry L. Wald, Elfar Adalsteinsson,

Minimum SAR for RF Shimming by Allowing Spatial Phase Variation ...... 5357 Yigitcan Eryaman, Celal Alp Tunc, Ergin Atalar

MRI-Compatible 12-Lead ECG: Improved MHD Suppression, Ischemia Monitoring, and Non-Invasive Cardiac Output...... 5358 Ehud Jeruham Schmidt, Gari Clifford, Michael Jerosch-Herald, Raymond Y. Kwong, Laurence Epstein,Daniel Kacher, Charles L. Dumoulin, Ferenc Jolesz

Optimization of SAR Calculation for 3-D EM Time and Frequency Domain Data ...... 5359 Mikhail Kozlov, Thomas Rothe, Robert Turner

Acoustic Noise Reduction Through Pulse Sequence Design: Timings, Eddy-Currents, fMRI...... 5360 Xingxian Shou, Xin Chen, Jamal J. Derakhshan, Jeffrey L. Duerk, Robert W. Brown

Experimental Study of Active Acoustic Noise Control in a 4T MRI Scanner In-Situ...... 5361 Brent Rudd, Mingfeng Lee, Teik C. Lim, Jing-Huei Lee

Numerical Determination of SNR Using an Anatomic Pixel Rat Brain Model...... 5362 Rafael Rojas, Sergio Enrique Solis, Oscar Rene Marrufo, Alfredo Odon Rodriguez

Modeling of RF Induced Implant Lead Current for MRI...... 5363 Volkan Acikel, Ergin Atalar

Fluoroptic Measurements of MRI-Related Heating at Cardiac Pacemaker Leads in Vivo: Initial Results ...... 5364 Peter Nordbeck, Oliver Ritter, Michael Friedrich, Michelle Maxfield, Marcus Warmuth, Philipp Ehses, Ingo Weiss, Karl-Heinz Hiller, Peter M. Jakob, Mark E. Ladd, Harald H. Quick, Wolfgang R. Bauer

The Safety of MRI in Patients with Implanted Sacral Neuromodulation Systems: RF-Induced Heating...... 5365 John S. Thornton, David W. Carmichael, Shahid Khan, Clare J. Fowler, Thomas M. Kessler

SAR Behavior During Whole-Body MultiTransmit RF Shimming at 3.0T...... 5366 Paul R. Harvey, Zhiyong Zhai, Michael Morich, Giel Mens, Gert van Yperen, Gordon DeMeester, Ingmar Graesslin, Romhild Hoogeveen

SAR Reduction in Parallel Transmission by Allowing Spatial Phase Variation...... 5367 Haldun Ozgur Bayindir, Yigitcan Eryaman, Celal Alp Tunc, Ergin Atalar

A Multi-Channel SAR Prediction and Online Monitoring System at 7T ...... 5368 Irina Brote, Stephan Orzada, Oliver Kraff, Stefan Maderwald, Harald H. Quick, Pedram Yazdanbakhsh, Klaus Solbach, Karsten Wicklow, Achim Bahr, Thomas Bolz, Mark E. Ladd, Andreas K. Bitz,

Realisation of a Flexible Power Measurement Application for Parallel Transmit ...... 5369 Guido Kudielka, Mika Vogel, Wolfgang Loew

Feasibility of Active Cable Trap to Attenuate MRI-Induced RF Currents...... 5370 Marta Gaia Zanchi, John Mark Pauly, Greig Cameron Scott

Improved RF Safety of Interventional Devices Using Cable Traps...... 5371 Krishna N. Kurpad, Erik T. Bieging, Mahdi S. Rahimi, Orhan Unal

New Method to Quantify RF Induced Currents Inside Conductive Wires...... 5372 Michiel R. van den Bosch, Marinus A. Moerland, Astrid L. van Lier, Lambertus W. Bartels, Jan J. Lagendijk, Cornelis A. van den Berg

Continuous Monitoring of RF-Safety for Implantable MR-Conditional Devices...... 5373 Ingmar Graesslin, Julia Weller, Peter Koken, Jouke Smink, Bjoern Annighoefer, Sascha Krueger

Safety of Simultaneous Intra-Cranial EEG-fMRI: Magnetic Field Gradient Induced Voltages...... 5374 David W. Carmichael, Louis Lemieux

3D MRI Thermometry of MR-Induced Heating of a Wire and Determination of Total Generated Heat...... 5375 Philipp Ehses, Marcos A. Lopez, Michael Friedrich, Florian Fidler, Peter Nordbeck, Marcus Warmuth, Peter M. Jakob, Wolfgang R. Bauer

RF Heating Due to a Deep Brain Stimulation Electrode at 9.4 T (400.2 MHz) in Porcine Heads ...... 5376 Devashish Shrivastava, Timothy Hanson, Aviva Abosch, J. Thomas Vaughan

The Effect of Human Model Resolution on Numerical Calculation of SAR and Temperature in MRI...... 5377 Zhangwei Wang, Christopher M. Collins, Shuren Zhao, Fraser J. Robb

A Comparison of Local SAR Using Individual Patient Data and a Patient Template ...... 5378 Stefanie Buchenau, Martin Haas, Juergen Hennig, Maxim Zaitsev

A Standard Implant for Determination of Local SAR in Testing of RF-Induced Heating of an Implant ...... 5379 John A. Jallal, John A. Nyenhuis, Sung Min Park

Occupational Exposure to Electro-magnetic Fields in MRI: A Survey of Working Practices from 1 T-7 T……………………….5380 D.W. McRobbie, M. Oberle, A. Papadaki, R. Quest, K. Hansson Mild, M. Capstick, J. Hand, N. Kuster

Transmit Array Concepts for Improved MRI Safety in the Presence of Long Conductors...... 5381 Maryam Etezadi-Amoli, Marta Gaia Zanchi, Pascal Stang, William R. Overall, Adam B. Kerr, John M. Pauly, Greig C. Scott

RF Energy Deposition and RF Power Requirements in Parallel Transmission with Increasing Distance from the Coil to the Sample...... 5382 Cem Murat Deniz, Riccardo Lattanzi, Yudong Zhu, Graham Wiggins, Daniel K. Sodickson

SAR Assessment of Transmit Arrays: Deterministic Calculation of Worst- And Best-Case Performance...... 5383 David Otto Brunner, Jan Paska, Juerg Froehlich, Klaas Paul Pruessmann

The Effect of Solution Electrical Conductivity in Pacemaker Lead Tip Heating at 1.5 Tesla...... 5384 Deborah Anne Langman, Ira B. Goldberg, Paul J. Finn, Jack W. Judy, Daniel B. Ennis

Resistance and Inductance Based MRI-Safe Implantable Lead Strategies ...... 5385 Paul A. Bottomley, William A. Edelstein, Ananda Kumar, Justin M. Allen, Parag Karmarkar

Author Index