Mouse CD antigens

Molec. Molec. Molec. Molec. Antigen Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor mass mass mass mass CD1d CD1.1/1.2, 43–49 Leukocytes, intestinal epithelial cells Antigen presentation, mucosal immunity, CD1-restricted TCR CD81 TAPA-1 26 kDa Tact cells, B cells, NK cells, With CD19 and CD21, signaling; – CD169 Sialoadhesin, 185 kDa Tissue subsets, Adhesion; cell–cell and cell–matrix CD43, CD206, CD278 ICOS, inducible 55–60 Tact and Th2 cells T cell co-stimulation, B7-H2 receptor, CD275 Ly-38 kDa associates with β-2-microglobin, ligand for thymocyte subsets, DCs, endothelial T cell co-stimulation Sn, -1 interactions; binds α2,3-sialylated ligands CD227 T cell CO- kDa cytokine production NKT cells cells, fibroblasts, melanomas, Stimulator, neuroblastomas, CD170 Siglec-F 140 kDa Macrophage subsets, , Adhesion – Ly115 CD2 LFA-2, Ly-37, 45–58 Lymphocytes, pre-B cells, Adhesion, T cell activation CD48 eosinophils SRBC-R kDa erythrocytes, myeloid cells, DCs CD82 KAI1, C33 50–53 Tact cells; mRNA: spleen, kidney Inhibition of tumor cell mobility – CD279 PD-1, 55 kDa Tact and Bact cells Negatively regulates lymphocytes, CD273, CD274 kDa CD171 , cell adhesion 200– CNS, PNS, glial cells, monocytes, T Homotypic adhesion; T cell co-stimulation; CD9, CD24, CD56, programmed T cell development CD3δ T3d 20 kDa T cells, thymocyte subsets, NKT cells TCR subunit; TCR expression and signaling MHC ligand: peptide molecule 210 cell subsets, B cells, DCs, lymph node integrin binding; knockout has CD142, CD166, death-1 CD83 HB15 43 kDa Mature DCs, Tact cells, thymic Regulation of T response – kDa reticular fibroblasts, some epithelial neuropathologies similar to CRASH disorder CD171, , T3e 20 kDa T cells, thymocyte subsets, NKT cells TCR subunit; TCR expression and signaling MHC ligand: peptide epithelial cells cells phosphocan, laminin CD280 ENDO180, 180 kDa Chondrocytes Collagen matrix remodeling, endocytic Mannose, fucose CD3ε UPARAP, MRC2 recycling on glycans CD84 SLAMF5, GR6 70–85 T cells, subset, NKT cells, T Homophilic adhesion, T/B cell interaction – CD172a SIRPα, Ptpns1 110 kDa Monocytes, macrophages, DCs, Adhesion, signal transduction CD47 CD3γ T3g 25 kDa T cells, thymocyte subsets, NKT cells TCR subunit; TCR expression and signaling MHC ligand: peptide kDa follicular helper cells, myeloid cells, neurons, stem cells CD281 TLR1 90 kDa Low levels in leukocytes, Innate immunity with CD282 (TLR2) Lipoprotein, CD4 Ly-4, L3T4 55 kDa Thymocyte subsets, T cell subsets, TCR co-receptor, thymic differentiation, MHC class II, IL-16 hematopoietic stem cells macrophages lipopeptide CD172b SIRPβ 60–90 Myeloid Engagement of SIRPβ promotes – DC subsets T cell activation CD85k GP49b, LILRB4, 37 kDa NKact cells, mast cells, myeloid cells Inflammation, inhibitor of cellular function MHC class I kDa phagocytosis in macrophages CD282 TLR2 90 kDa Myeloid lineage: macrophages and Response to bacterial lipoproteins Lipoproteins, gp49 receptor DCs in spleen glycans CD5 Ly-1 67 kDa Thymocytes, T cells, B1 cells T cell activation, T and B cell interaction CD72 CD176 Thomsen- Broad in embryo and tumor Migration act act CD6 T12 100– Thymocytes, T cells, neurons, not T cell differentiation and co-stimulation CD166 CD86 B70, B7-2, 80 kDa Monocytes, B cells, T cells, DCs T cell co-stimulation, T and B cell interaction CD28, CD152 Friedenreich CD283 TLR3 120 kDa DC subsets, macrophages, Activation of NF-κB dsRNA 130 on B cells Ly-58 tumor antigen fibroblasts, induced by LPS (intracellular) kDa CD87 UPA-R, PLAUR 37–70 Luminal epithelial cells of gastric PAR2-secreted uPA-binding , uPA CD177 NB1, Pdp3 56–62 subsets (surface and Migration CD31 (PE-CAM) CD7 40 kDa Human early T cell marker, CD7 – – kDa mucosa, neutrophils, macrophages, cell–matrix interactions kDa intracellular) CD284 TLR4, Ly87, 100 kDa Thioglycolate-elicited peritoneal Innate immunity LPS DCs Rasl2-8 macrophages knockout has normal phenotype CD178 , 38–42 Tact cells, testis; RNA: NK cells Apoptosis of CD95+ cells, immune privilege, CD95 Ly-2 32–34 Thymocyte subsets, T cell subsets, T cell differentiation; homodimer or MHC class I CD88 C5aR, C5r1 40 kDa Granulocytes, neurons, astrocytes, Neurodegeneration C5a CD95L, TNFSF6 kDa soluble form in serum, gld mutation CD285 TLR5 90 kDa DCs, monocytes, epithelial subsets – – CD8α microglia, DC subset kDa DC subsets, not fresh NK cells heterodimer with CD8β nonfunctional FasL CD286 TLR6 85 kDa Leukocytes, monocytes, DCs Pathogen recognition, activation of innate Bacterial diacyl- Ly-3 30 kDa Thymocyte subsets, T cell subsets, TCR co-receptor, T cell differentiation, MHC class I CD89 FcαR, IgA 55–75 Monocytes, macrophages, Phagocytosis, degranulation IgA CD179a pre-BCR, V 16 kDa Pro- and early pre-B cells B cell differentiation, signaling, pre-BCR – immunity lipopeptides CD8β receptor kDa neutrophils, B and T cell subsets not fresh NK cells homodimer or heterodimer with CD8α pre-B with IgM/CD79α/β CD288 TLR8 120 kDa Macrophages, DC subsets, Pathogen recognition, activation of innate GU-rich RNA CD9 p24 24–27 Myeloid cells, platelets, Tact cells, Adhesion, migration, T cell co-stimulation – CD90 Thy-1 18 kDa Thymocytes, T cells, hematopoietic Hematopoietic stem cell and neuron CD11b/CD18 CD179b pre-BCR, 22 kDa Pro- and early pre-B cells B cell differentiation, signaling, pre-BCR – plasmacytoid DCs, leukocytes immunity kDa B cell subsets, stromal cells, subsets, neurons differentiation, T activation lambda 5 with IgM/CD79α/β CD289 TLR9 120 kDa DC subsets (intracellular) Binds CpG DNA Pathogen- mesenchymal stem cells CD90.1 Thy-1.1 18 kDa Thy1a (Thy1.1) strains: AKR, RF, – – CD180 RP105, Ly-78 95–105 B cells, monocytes, DCs B cell recognition and signaling of LPS; with – associated CD10 CALLA, NEP, 100 kDa Fibroblasts, bone marrow stromal Zinc-binding metalloproteinase, neutral – and PL kDa MD-1, regulation of B cell growth and death molecular patterns, Mme cells, non-lymphoid tissue endopeptidase ectoenzyme CpG DNA found in CD90.2 Thy-1.2 18 kDa Thy1b (Thy1.2) strains: Balb/c, – – CD181 CXCR1, IL8Rα 39 kDa Neutrophils, basophils, NK cells, T cell Chemotaxis of neutrophils IL-8 bacteria and viruses CD11a Integrin αL, 80 kDa T, B, and NK cells; granulocytes, Heterodimer with CD18, adhesion, CD54, CD102, CBA/J, C57BL/6, DBA, NZB, C3H/ subsets, monocytes He, SJL CD292 BMPR1A, ALK3 57 kDa Bone progenitor, broad Binds BMP 2 and 4, bone development, BMP-2, BMP-4 Ly‑15, ITGAL monocytes, macrophages, DCs, T cell co-stimulation CD242, CD50 CD182 40 kDa Neutrophils, basophils, NK cells, T cell Chemotaxis of neutrophils, also binds GRO thymocytes CXCR2, IL8Rβ IL-8; GRO-α, β, germ layer specification CD91 LRP1, α2MR 600 kDa Monocytes, macrophages, neurons, Lipoprotein metabolism -2-macroglobulin, subsets, monocytes and NAP-2 and ; NAP-2 α γ CD293 BMPR1B, ALK6 57 kDa Bone progenitor, developing retina Binds BMP, bone development, BMP-7, GDF5 CD11b Mac-1, integrin 170 kDa Myeloid, NK, and Tact cells; Heterodimer with CD18, adhesion to ECM, CD54, CD102, liver, fibroblasts, DCs LDLs, HSP96 CD183 CXCR3, Cmkar3, 40 kDa Tact cells (Th1), NK cells, eosinophils, T cell recruitment to inflammatory sites, CXCL9, CXCL10, neurogenesis αM, ITGAM, B cell subsets fibrinogen, and complement iC3b fibrinogen, iC3b CD93 AA4.1 antigen, 130– Progenitor marker for early B cells, Phagocytosis C1q, MBL2, SPA gpr9 GM-CSF–activated hematopoietic Th1 cell response, allograft destruction CXCL11 CR3 CD294 CRTH2, GPR44 55–70 Th2 cells, eosinophils, basophils Chemotaxis Binds prostaglandin C1qRp, early B 140 endothelial cells, megakaryoblasts, progenitors kDa D2 CD11c p150, integrin 150 kDa DCs, myeloid cells, NK cells, Heterodimer with CD18, adhesion Fibrinogen, iC3b lineage marker, kDa platelets CD184 CXCR4, Cmkar4, 45 kDa T cell subsets, B cells, DCs, Embryogenesis, lymphocyte migration, B cell CXCL12 (SDF-1) αX, ITGAX, CR4 T cell subsets Ly68 CD295 LeptinR, LEPR 132 kDa Broad Adipose metabolism, may be involved in Leptin fusin/LESTR, monocytes, endothelial cells development (human: 4 HIV co-receptor) immune dysfunction in obesity CD13 Aminopeptidase 150 kDa Myeloid cells, endothelial cells, DCs Zinc-binding metalloproteinase, antigen – CD94 KP43, 43 kDa NK cells, NKT cells Complex with NKG2, inhibition of NK MHC class I HLA-E sdf1r N, Lap1 processing cell function CD296 ART1, RT6, 37 kDa Heart and skeletal muscle, peripheral GPI-linked protein modifies integrin during – CD185 CXCR5, BLR1 45 kDa Spleen, resting B cells, T cells, skin- B cell migration into B cell follicles of spleen CXCL13 ART2 T cells, NK cell subsets differentiation CD14 LPS-R, Mo2 53–55 Macrophages, granulocyteslow LPS recognition, apoptosis LPS complex with CD95 Apo-1, Fas 35 kDa Thymocytes, lymphocytesact, Apoptosis induction, immune system CD178 derived DCs and Peyer’s patches kDa LPS-binding protein fibroblasts, monocytes, neutrophils regulation CD297 ART4, Dombrock 38 kDa Heart, lung, liver, spleen, erythroid, – – CD186 CXCR6 40 kDa Memory T cells Inflammatory response CXCL16 blood group monocytesact CD15 Lewis-X >150 Transient in brain stem cells Carbohydrate interaction – CD96 TACTILE 160 kDa T cells, NK cells Adhesion of activated T and NK cells CD155 CD191 CCR1, MIP-1αR, 39 kDa Neutrophils, monocytes, lymphocytes, Activation CCL3, CCL5, kDa (T cell activation CD298 Na+/K+-ATPase 52 kDa Broad Transporter – RANTES-R eosinophils, osteoclasts CCL7, CCL8, CCL9, increased late 3 subunit, CD16 50–60 NK cells, neutrophils, mast cells, Aggregated IgG CCL10, CCL13, β FcγRIII, Ly-17, Fcγ low-affinity receptor, phagocytosis, expression) ATP1B3 Fcγr3 kDa macrophages antibody-dependent cell-mediated CCL15, CCL16, cytotoxicity, NK cell activation CD97 TM7LN1, TM7S 90 kDa Lymphoid and myeloid cells Adhesion CD55 CCL23 CD300a Clm8, LMIR1, 35 kDa T and B cell subset, myeloid cells Receptors of the IgSF involved in immune – MMAC8, Pigr4, regulation CD98 4F2, Ly-10 80, Thymocytes, lymphocytes, Cell activation, calcium flux – CD192 CCR2 40 kDa T cell subsets, monocytes Chemotaxis CCL2, CCL7, CCL8, CD18 Integrin β2, 90–95 Leukocytes Heterodimer with CD11a, b, or c; adhesion CD54, CD102, MAIR-I, mcpir1 ITGB2 kDa fibrinogen, iC3b 40 kDa monocytes, bone marrow CCL12, CCL13 CD300lb Irem3, Lmir5 – Myeloid cells, mast cells Proposed activating receptor – CD19 B4 95 kDa B cells, follicular DCs, good B cell Complex with CD21, BCR co-receptor, – CD99 PILRβ, D4 32 kDa Cortical thymocytes Adhesion, T cell development – CD193 CCR3, MIP- 45 kDa Mast cells, basophils, platelets Chemotaxis CCL5, CCL7, CCL8, lineage marker, not plasma cells B cell activation/differentiation 1αRL2 CCL11, CCL13, CD300c Clm6 – Evidence at the transcript level – – CD100 Sema4d, 150 kDa Hematopoietic cells, T cells T/B cell interactions CD72, plexin B1 CCL15, CCL24, CD20 Ly-44, B1, 33–37 B cells, transitional T1 B cells B cell activation/differentiation – semaphorin H CCL26 CD300e Clm2 – Evidence at the transcript level Proposed activating receptor – MS4A2 kDa CD101 IgSF3 131 kDa Myeloid cells, DCs, T cell subsets, Role in susceptibility to type I diabetes – CD194 CCR4 41 kDa T cell subsets, B cells, macrophages Chemotaxis of leukocytes CCL17, CCL22 CD300lf Clm1, Lmir3 – Myeloid cells, mast cells, B cells Inhibitory receptor for myeloid cells and – Treg cell subsets mast cells CD21 CR2, CR1 150 kDa B cells, DCs CD21/CD35 variant of CR2 gene; C3d low complement C3dR; with CD19 and CD81, CD195 CCR5, Cmkbr5 45 kDa T cell subsets, NK cells, monocytes Chemotaxis CCL3, CCL4, CCL5, CD102 ICAM-2, Ly-60 55–65 Lymphocytes, monocytes, platelets, Co-stimulation CD11a/CD18 CCL8 CD301a Macrophage – Macrophages, immature DCs Cell adhesion GalNAc BCR co-receptor kDa endothelial cells galactose type-C CD22 Lyb-8, Siglec-2 140– B cells Adhesion, B cell– interactions, CD75 CD196 CCR6, KY411 45 kDa Mainly B cells; T cell and DC subsets Chemotaxis, Th17 cell differentiation CCL20 (MGL1) CD103 Integrin αIEL, 150 kDa Intra-epithelial lymphocytes, bone Complex with integrin β7; lymphocyte E-cadherin 160 B cell–T cell interactions, B cell activation, act CD197 CCR7, Cmkbr7 45 kDa T cell and DC subsets Migration, differentiation CCL19, CCL21 CD301b Macrophage Dermal DCs, BMDCs, connective TH2 priming, cell adhesion GalNAc + HML-1, ITGAE marrow mast cells, lymphocytes , homing kDa bone marrow homing receptor for IgD B galactose type-C tissue, macrophageslow Treg cell subsets CD198 CCR8, CC-CKR8 50 kDa Monocytes, macrophages, Chemotaxis CCL1 cells lectin (MGL2) CD104 β4 integrin, 220 kDa Epithelial cells, endothelial cells, Complex with CD49f, cell adhesion/ Laminin neutrophils, T cell subsets CD23 Fc RII, Ly-42, 45–49 B cells, not B1 cells, monocytes, Signal transduction IgE, CD21, CD11b, CD302 DCL-1, Clec13A 30 kDa Macrophages Cell adhesion and migration – ε ITGB4 immature thymocytes, Schwann cells, migration, differentiation, tumor metastasis CD199 CCR9, 43 kDa High in thymus; immature and mature Chemotaxis, role in T cell development after CCL25 Fcεr1a kDa macrophages, granulocytes, platelets, CD11c tumor cells, keratinocytes follicular DCs CMKBR10 T cells chemotaxis CD304 BDCA4, 130 kDa Thymic Treg cells, NKT cells, DCs, Axonal guidance, angiogenesis, cell survival, Semaphorin-3A, 1, stem cells, neurons, endothelial cells, migration vascular endothelial CD105 , Eng 95 kDa Endothelial cells, bone marrow cell Adhesion, embryonic angiogenesis TGF-β CD200 OX-2 45–50 Thymocytes, B cells, Tact cells, DCs, T cell co-stimulation, regulation of CD200R CD24 HSA, Ly-52, 35–52 B cells, granulocytes, monocytes, Several isoforms, B cell differentiation and CD62P subsets, macrophagesact Nrp, NP-1 some neoplastic cells growth factor A, act kDa endothelial cells, neurons oxidoreductase pathway nectadrin kDa macrophages, T cells, erythrocytes, adhesion, T cell co-stimulation plexin-1 act neurons CD106 VCAM-1 110 kDa Endothelial cells , follicular dendritic Adhesion/migration, co-stimulation CD49d/CD29, CD200R OX-2R – Myeloid cells, lymphocyte subsets, Inhibitory receptor, signal transduction CD200 cells, bone marrow myeloid CD49d/ 7 CD305 LAIR1 32–40 Broad, NK cells, B cells, T cells, Inhibitory receptor on NK and T cells – act β Langerhans DCs, dendritic epidermal CD25 Ly-43, p55, 55 kDa Pre-B, pre-T, Treg, and B cells, DCs Low-affinity IL-2 binding, complex with IL-2 kDa monocytes IL2Rα CD122 and CD132 to form high-affinity CD107a LAMP-1 120 kDa Plateletsact, Tact cells, endothelial Lysosomal membrane protein, metastasis -3, CD62L, T cells act CD307a FCRL1 (Fc 50 kDa Mature B cells Putative role in B cell activation and – IL-2 receptor, signal transduction cells , macrophages CD62E, CD62P CD201 Procr, EPC-R 25 kDa Endothelial cells, hematopoietic stem Regulate blood coagulation Protein C receptor-like 1), differentiation act act act cell subsets CD26 DPP4, THAM 110 kDa Thymocyte subsets; T , B, NK, and Dipeptidyl peptidase ectoenzyme, activation, Collagen, fibronectin CD107b LAMP-2 110 kDa Platelets , T cells, endothelial Lysosomal membrane protein, metastasis Galectin-3, CD62L, FCRH1, IFGP1, act epithelial cells adhesion cells , macrophages CD62E, CD62P CD202b Tie2, Tek 140 kDa Stem cells, endothelial cell subsets Angiogenesis Angiopoietin-1 IRTA5, FCRL1 CD27 T14, TNFRSF7 45 kDa Medullary thymocytes, T cells, NK T cell co-stimulation CD70 CD108 Sema7a 44 kDa Nervous system (high on myeloid and Adhesion/migration CD232 CD203c ENpp3, PC-1, 115 kDa Antibody-secreting B cells, basophils, Plasma cell alloantigen, ectoenzyme, Nucleotides CD307b FCRL2 (Fc 55 kDa Memory B cells Putative role in B cell development – cells, B cell subsets pDCs), B cells TWY mast cells, megakaryocytes, binding/clearance of extracellular receptor-like 2), act glioma cells nucleotides FCRH2, IFGP4, CD28 Tp44 45 kDa T cells, thymocytes, NK cells T cell co-stimulation CD80, CD86 CD109 Gov platelet 158 kDa T cell subset and platelets , Adhesion of ECM TGF β IRTA4, SPAP1, alloantigen Langerhans DCs, epithelial cells, CD204 MSR 220 kDa Macrophage subset (M2) Endocytosis of macromolecules LDL CD29 Integrin β1, 130 kDa Leukocytes, fibroblasts, endothelial Heterodimer with CD49a-f to form CD106, ECM, endothelium SPAP1A, SPAP1B, GPIIa, ITGB1 cells, epithelial cells VLA-1 through VLA-6, adhesion, MAdCAM-1 (macrophage SPAP1C embryonic development CD110 TPO-R, c-mpl 82–84 Megakaryocytes, platelets Megakaryocyte differentiation Thrombopoietin scavenger kDa receptor), ScvR CD307c FCRL3, Fc 89 kDa B and NK cells – – CD30 Ki-1, TNFRSF8 105– Tact cells Lymphocyte proliferation, apoptosis, CD153 low receptor-like 3, 120 peripheral tolerance CD111 PRR1, nectin-1, 64–72 Fibroblasts, epithelium, neurons Polio virus receptor–related protein 1, entry HSV, CD113 CD205 DEC-205, Ly75 205 kDa DCs, thymic epithelial cells, B cells, Antigen uptake/presentation, immune – FCRH3, IFGP3, kDa Pvrl kDa of HSV bone marrow stromal cells, pulmonary inhibition IRTA3, SPAP2 epithelial cells, brain capillaries CD31 PECAM-1, GPIIa 130– Leukocytes, endothelial cells Multiple isoforms, signaling, platelet– CD31, CD38 CD112 PRR2, Pvs, 64–72 Brain, spinal cord, spleen, kidney, Adhesion, not a receptor for polio virus HSV, CD111, CD113 CD307d FCRL4, Fc 57 kDa Memory B cells Possible inhibition of B cell receptor – 140 endothelial cell adhesion nectin-2 kDa heart, liver, macrophages, DCs CD206 Macrophage 180 kDa Macrophage subset (M2), DC subset, Phagocytosis/pinocytosis of mannose- Oligomannose- receptor-like 4, kDa mannose endothelial cells containing molecules containing FCRH4, IGFP2, CD113 PVRL3, nectin-3 100 kDa Broad, epithelial cells Adhesion molecule, interacts with afadin CD111, CD112 receptor (MMR), carbohydrates IRTA1 CD32 FcγRII, Ly-17, 40–60 Monocytes, macrophages, Antibody-dependent cell-mediated Aggregated CD114 G-CSFR, 95, 139 Progenitor and mature neutrophils, Myeloid proliferation and differentiation G-CSF Mrc1 Fcγr2b kDa granulocytes, B cells, Tact cells, cytotoxicity IgG/immune CD307e FCRL5, Fc 106 kDa B cells Putative role in B cell development and – CSFGR, CSF3R kDa endothelial cells, placenta, some not NK cells complexes CD207 40 kDa Langerhans DCs Antigen capture and endocytic receptor, Mannose-bearing receptor-like 5, differentiation myeloid leukemias with Birbeck granules glycoproteins and CD307, FCRH5, CD33 Siglec-3, gp67 67 kDa Myeloid progenitors, granulocytes, Possible role in hematopoiesis Sialic acid glycolipids IRTA2, BXMAS1, microglia CD115 M-CSFR, c-fms, 150 kDa Monocytic progenitors, osteoclasts, Monocytic lineage proliferation/ M-CSF CSF1R macrophages differentiation, role in differentiation of CD208 DC-LAMP, 70–90 Activated DCs, interdigitating DCs Lysosomal protein – PRO820 CD34 Mucosialin 90–120 Hematopoietic precursors, capillary Adhesion CD62L osteoclasts Lamp3 kDa CD309 VEGFR2, Flk-1, 230 kDa Endothelial cells, angiogenic precursor Regulates adhesion and cell signaling VEGF kDa endothelial cells, bone marrow KDAR cells, hemangioblasts stroma, mast cells CD116 CSF2RA, GM- 70–85 Monocytes, granulocytes, DCs, Proliferation, differentiation GM-CSF CD209a DC-SIGN, CIRE 44 kDa DC subsets T cell and DC interaction CD54 CSF receptor kDa endothelial cells α CD314 NKG2D, KLRK1 42 kDa NK cells, CD8+ activated, not CD4+ Cytolysis and cytokine production; MHC class I, Rae1, CD35 Cr1, Cr2 190 kDa B cells, granulocytesact, follicular DCs CD21 and CD35 alternative splice variants C3b, C4b CD209b SIGN-R1 – Macrophage subsets (splenic, LN) – CD50 in the periphery, macrophagesact co-stimulatory ULBP4 of Cr2 gene, adhesion, phagocytosis CD117 c-, steel factor 145 kDa Hematopoietic stem and progenitor Activation of mast cells SCF cells, mast cells, neural crest–derived CD209c – – Evidence at the transcript level Probable pathogen-recognition receptor – CD315 CD9P1, SMAP6, 135 kDa B cell subsets, monocytesact Complexes with CD81 and CD9 – CD36 FAT, fatty acid 88 kDa Platelets, adipocytes, monocytes, Apoptosis, adhesion Collagen (I, IV, V), melanocytes, primordial germ cells CD209d – – Evidence at the transcript level Probable pathogen-recognition receptor – FPRP, PTGFRN translocase macrophages, endothelial cells, thrombospondin, CD118 LIFR 190 kDa Placenta, liver, kidney, heart, lung, Signal transduction, soluble form inhibits LIF erythrocytes, B cells oxidized LDL CD209e – – Evidence at the transcript level Probable pathogen-recognition receptor – CD316 EWI2, PGRL, 63–75 B cells, T cells, low on NK cells Complexes with CD81 and CD9, – brain epithelial cells LIF activity KASP kDa involved in cell migration CD37 Tspan26 40–60 Mature B cells, macrophagelow, T and B cell interaction, B cell survival – CD210 90–110 Th1 cells, B cells, NK cells, Signaling, related to IFN receptors IL-10 CD119 90–100 Macrophages, monocytes, B cells, Host defense, signal transduction IL-10Rα kDa monolow, neutrophillow IFNγR, ifγr1, IFN-γ kDa monocytes, mast cells, macrophages CD317 BST2, PDCA-1 30–36 Plasmacytoid DCs Trafficking of cytokines – kDa T cells, NK cells, neutrophils, Ifnγr kDa CD38 CD38-Rs1, T10 42 kDa B cells, marginal zone B cells (high), Ectoenzyme, ADP-ribosyl cyclase/hydrolase, CD31 endothelial cells CDw210b IL-10Rβ – T cells, B cells, NK cells, monocytes, – IL-10, IL-22 Tact cells, thymocyte subsets, subsets adhesion, proliferation macrophages CD318 CDCP1, 92 kDa Epithelial cells Adhesion – in yolk sac, fetal liver, and bone CD120a TNFR1, p55 50–60 Broad Apoptosis, signal transduction TNFα, TNFβ CD212 100 kDa Tact and NKact cells High-affinity binding to IL-12, with IL-12 IL-12 CUB domain- marrow kDa IL-12Rβ1 receptor b2; signaling; T and NK cell containing protein 1 CD39 Entpd1 70–100 Lymphocytesact, microglia, endothelial Ecto-nucleoside trisphosphate Nucleoside tri- and CD120b TNFR2, p75 75–85 Broad Apoptosis, signal transduction TNFα, TNFβ response to IL-12, signal transduction kDa cells, Treg cell subsets diphosphohydrolase, proliferation, diphosphates kDa CD213a1 65 kDa Monocytes, NK cells, fibroblasts, Low-affinity binding of IL-13, complexes IL-13 CD319 CRACC, 66 kDa T cell subset, B cells, NK cells NK cell activation – ATP clearance low IL-13Rα1, NR4 CD121a IL-1R, type I 80 kDa Broad Signal transduction IL-1α, IL-1β, IL-1Rα endothelial cells with CD124, inflammatory signaling SLAMF7 CD40 TNFRSF5 45–50 B cells, monocytes, macrophages, T and B cell interaction, B cell co- CD154 CD121b IL-1R, type II 68 kDa B cells, macrophages, monocytes, A decoy receptor CD213a2 65 kDa B cells, monocytes High-affinity binding of IL-13, signal IL-13 CD320 VLDL, Ng29 60 kDa Liver, kidney, placenta; B cell subset – Transcobalamin kDa T cell subsets, DCs, endothelial cells, stimulation, isotype switching, survival IL-1α, IL-1β, IL-1Rα IL-13Rα2 Th2 cells, epidermis transduction thymic epithelial cells, induced on CD321 JAM1, F11 32–41 Epithelial cells, endothelial cells, Tight junction, binds reovirus and LFA1, CD11a/CD18, CD122 90–110 NK cells, T cells, B cells, monocytes, IL-2R and IL-15R chain; signaling; with IL-2, IL-15 receptor, KAR kDa platelets platelet receptor reovirus cardiac myocytes IL-2Rβ, p70 CD215 IL-15Rα T and B cells Complexes with CD132 and CD122, IL-15 kDa Treg cells CD25 and CD132, form high-affinity IL-2R; development and survival of NK cells CD322 JAM2, VE-JAM 45 kDa High in endothelial venules and other Mediates trans-endothelial migration of – CD41 GPIIb, ITGA2B, 110– Platelets, megakaryocytes Complex with CD61; forms GPIIb/IIIa; Fibrinogen, lymphocyte development CD41b 125 platelet activation and aggregation fibronectin, vWF, CD217 IL-17R 120 kDa Granulocytes Signal transduction, neutrophil development IL-17 endothelial cells lymphocytes kDa thrombospondin CD123 IL-3Rα 70 kDa Lymphocyte subsets, basophils, Low-affinity binding to IL-3; with CDw131, IL-3 CD324 E-cadherin, 120 kDa Non-neural epithelial cells Binding to integrin aE/b7 and homotypic CD103, PS1, CD218a IL-18Rα, IL1Rrp 70 kDa Th1 cells, NK cell subsets, neutrophils IL-18 hematopoietic progenitors, form high-affinity IL3 binding, signal Th1 cell differentiation, activation of NF‑κB uvomorulin interactions mediate cell adhesion catenins, internalin CD42 GP9, GPIX 20 kDa Platelets, megakaryocytes Platelet activation, aggregation macrophages, plasmacytoid DCs, transduction CD218b IL-18Rβ, 70 kDa T cells, NK cells, DCs IL-18 CD42a GPIX, GP9 22 kDa Platelets, megakaryocytes Complex with CD42b, c, and d; platelet vWF, thrombin megakaryocytes Forms heterodimeric receptor with IL‑18Rα CD325 N-cadherin, 140 kDa Brain, skeletal muscle, cardiac muscle Adhesion, may be involved in neuronal N-cadherin, IL18RAP to enhance IL-18 binding cadherin-2 recognition mechanism catenins, FGFR, PS1 adhesion/activation low CD124 IL-4Rα 140 kDa Lymphocytes , monocytes, Complex with CD132 or IL-13Rα chain, T IL-4, IL-13 hematopoietic precursors, fibroblasts, CD220 , 140, 70 Broad Regulation of metabolism Insulin CD326 Ep-CAM, EGP, 40 kDa Epithelial cells Adhesion, migration CD305, CD326 CD42b GPIbα 145 kDa Platelets, megakaryocytes Complex with CD42a, c, and d; platelet vWF, thrombin cell growth and differentiation, soluble form adhesion/activation epithelial cells IR kDa Ly-74 CD125 60 kDa Eosinophils, basophils Complex with CDw131 for low-affinity IL-5 IL-5 CD221 IGF-1R 140, 70 Broad Signal transduction, IGF-I, IGF-II, insulin CD327 SIGLEC6 49 kDa Placenta, spleen, B cells, sialic acid Adhesion, membrane-bound and secreted forms, Sialyl-Tn motifs, leptin CD42c GPIbβ 24 kDa Platelets, megakaryocytes Complex with CD42a, b, and d; platelet vWF, thrombin IL-5Rα adhesion/activation binding, complex with β subunit for high- kDa proliferation/differentiation dependent sialic acid–dependent affinity IL-15 binding, signal transduction CD42d GPV 82 kDa Platelets, megakaryocytes Complex with CD42a, b, and c vWF, thrombin CD222 IGF-IIR, 220– Broad, 90–95% intracellular T cell coactivator; transport from TGFβ-L A P, CD328 SIGLEC7, AIRM-1 75 kDa Resting and activated NK cells; placenta, Sialic acid–dependent adhesion, inhibition of NK α2,3- and α2,6-linked act M6P/IGF2R 250 Golgi apparatus to lysosomes CD126 IL-6Rα 80 kDa B cells, plasma cells, most Low-affinity IL-6 binding; complex with IL-6 plasminogen, liver, spleen; lower in granulocytes and cell activation, hemopoiesis sialic acid CD43 Leukosialin, 115 and T cells, Tact cells, early B cells, B Isoforms, signaling, B cell survival, CD54 leukocyteslow, fibroblasts CD130 for high-affinity IL-6 binding; signal kDa proliferin, LIF, IGF-II monocytes Ly-48, Spn, 135 cell subsets, not resting B cells, adhesion transduction in soluble form sialophorin kDa plateletslow, not DCs CD223 LAG-3 70 kDa Tact and NKact cells Negative regulation of T cell activation, role MHC class II CD329 SIGLEC9 50 kDa Neutrophils, monocytes Sialic acid–dependent adhesion molecule α2,3- and α2,6-linked CD127 IL-7Rα 65–75 Pro-B cells, T cells With CD132, for high-affinity IL-7 binding; T IL-7 in natural killing sialic acid CD44 H-CAM, Pgp-1, 80–95 Hematopoietic and nonhematopoietic Adhesion Hyaluronic acid kDa and B cell development and activation Hermes antigen kDa cells, except platelets, hepatocytes, CD224 γ-glutamyl 27, 68 Yolk sac, protoplasmic astrocytes, Cleaves extracellular glutathione, cell – CD331 FGFR1, FLT2, 30 kDa Fibroblasts, epithelial cells Wound healing and bone development aFGF, bFGF testis CD128 See CD181 and – – – – transferase kDa endothelial cells, embryonic stem metabolism N-SAM CD182 1 (GGT1), cell lines CD45 LCA, Ly-5, 180– Leukocytes, not mature erythrocytes Tyrosine phosphatase, leukocyte – γ-glutamyl CD332 FGFR2, KGFR, 115– Fibroblasts, epithelial cells, ectoderm Embryonic limb development, AER aFGF, bFGF PTPRC 240 differentiation/activation, pan-leukocyte CD129 IL-9Rα – T, B, erythroid, and myeloid cell Association with CD132, B and T cell IL-9 transpeptidase KSAM 135 of embryo kDa marker precursors; mast cells; macrophages; development (GGTP) kDa epithelial cells CD333 FGFR3, ACH, 115 kDa Fibroblasts, epithelial cells, astrocytes Bone and CNS development aFGF, bFGF CD45.1 Ly5.1 180– Ly-5.2 strains: SJL, DA, STS/A, Tyrosine phosphatase, signal transduction – CD225 Interferon- 12 kDa Primordial germ cells Adhesion, differentiation – CD130 130 kDa Broad in adult and embryonic cells Oncostatin M, IL-6, CEK2 240 and RIII IL-6Rβ, GP130 Common β chain of IL-6R, IL-11R, LIFR, induced kDa OSMR, signal transduction LIF transmembrane CD334 FGFR4, TKF 110 kDa Fibroblasts, epithelial cells, Bone development aFGF, bFGF protein 1, CD45.2 Ly5.2 180– Ly-5.1 strains: BALB/c, C3H, Tyrosine phosphatase, signal transduction – CD131 IL-3R, AIC2B/A, 95–120 Monocytes, granulocytes, early B cells Two genes in mouse, signaling, with α – hepatocytes 240 C57BL/6, DBA/1, DBA/2, AKR, A, common kDa fragilis2, Mil2 subunits of IL-3, IL-5, GM-CSF receptors CD335 NKp46, Ly-94, 46 kDa NK cells NK cell activation Viral HA, kDa and 129 , Csf2rb1, β CD226 DNAM-1, PTA-1, 65 kDa Th1 cells, CD8+ T cells, platelets Platelet activation, T cell differentiation, CD112, CD155 MAR1 heparan sulfate Csf2rb2 CD45R B220 220 kDa B cells, NK cell progenitors, Tyrosine phosphatase, signal transduction – TLiSA1 co-stimulation, Th1 cell function lymphokine-activated killer cells, Tact CD132 64 kDa T cells, B cells, NK cells, monocytes, Subunit of receptors for IL-2, IL-4, IL-7, IL-13, – Common β CD227 Muc1, EMA 300 kDa Lymphocytes, tumors, epithelial cells, Adhesion, organogensis – CD336 NKp44, Ly-95 44 kDa NKact cells, T cell subsets Activation of NK cells upon non-MHC ligand Viral HA cells, T cells with lpr/lpr mutant alleles granulocytes, DCs and IL-15R; signaling; mutation: X-linked increased in pregnancy homolog binding SCID CD45RA – – – Exon A isoform, tyrosine phosphatase – CD228 , 80–95 mRNA: cartilage (high), testis – – CD337 Ncr3, IC7, Ly117 – Mouse IC7 mRNA in liver – – CD133 Prominin-1 115– Primitive cells like hematopoietic Unknown function – CD45RB – 200– T cell subsets, B cells, monocytes, Tyrosine phosphatase, signal transduction – Mfi2 kDa (moderate) 120 progenitors; neural, retina, and CD338 ABCG2, Mxr, 73 kDa Stem cell subsets (side population) Multidrug resistance transporter – 240 macrophages, DCs kDa epithelial cells CD229 Ly-9, Lgp100 95, 110 Thymocytes, T cells, B cells, bone Adhesion CD229 ABC15, BCRP1 kDa kDa marrow subsets, not erythrocytes CD134 OX-40, Ly-70, 48–50 Tact cells Apoptosis, T cell activation/differentiation CD252 CD339 Jagged-1, 135 kDa Bone marrow stromal and Hematopoiesis, Th2 cell fate Notch 1, notch 2, CD45RC – 200– T cell subsets, B cells Tyrosine phosphatase, signal transduction – Txgp1 kDa CD230 Prion protein, 35 kDa mRNA: DC subset, neurons – CD230 serrate1 macrophages, stromal cell lines notch 3 240 PrnP kDa CD135 Flt3/Flk2, EMS- 130– Hematopoietic progenitors: myeloid Myeloid and lymphoid development; FLT3 ligand CD340 ErbB-2, c-neu, 185 kDa Fetal heart, gonads, adult uterine Member of the ERBB family of receptor – like tyrosine 150 and primitive B cell progenitors, fetal expansion of hematopoietic progenitors CD231 TALLA-1, A15, 30–45 Transformed T cells; mRNA: brain, T cell acute lymphoblastic leukemia marker, – HER2 epithelial cells, and in synaptic sites of tyrosines; involved in a wide range of cellular CD46 MCP, membrane 41 kDa Broad Complement regulation, role in fertilization C3b, C4b kinase 3 kDa liver, adult bone marrow and DCs TSPAN7 kDa colon, muscle, heart, kidney, spleen neuronal function muscle fibers responses cofactor protein CD136 STK, MST1R, 180 kDa Hematopoietic cells – Macrophage CD232 VESP-R, 200 kDa Broad, DCs Possible role in DC function Pox virus–encoded CD344 Frizzled-4, F24 59 kDa Embryonic and adult tissue Activation of the Wnt/ -catenin pathway; Wnt, norrin CD47 I A P, I TG P, 50 kDa Hematopoietic cells, epithelial cells, Complex with 3 integrins; adhesion; Thrombospondin β β RON stimulating protein plexinC1 semaphorin protein regulation of tissue and cell polarity neurophilin endothelial cells, fibroblasts, platelets binds SIRP CD137 4-1BB, 30 kDa Tact cells, T cells, B cells, DCs, T cell co-stimulation CD137 ligand CD233 Band3, SLC4A1 90 kDa Erythrocytes; mRNA: epithelial cells, Anion pump, CO transport, linking – 2 CD349 Frizzled-9, Fzd9 65 kDa Selectively expressed in the Wnt-2, Wnt-7a CD48 Blast-1, BCM-1, 45 kDa Broad on lymphocytes, not fibroblasts Adhesion, T cell co-stimulation CD2, CD229 Activation of the Wnt/β-catenin pathway; TNFRSF9 macrophages (4-1BB ligand) other tissues membrane to cytoskeleton developing embryo and adult Sgp-60 regulation of tissue and cell polarity CD138 Syndecan-1, 80–150 Epithelial cells, plasma cells, B cell differentiation ECM CD234 Duffy, Dfy, DARC 36–37 RNA: endothelial cells, epithelial cells, Duffy blood group antigen chemokine – act CD350 Frizzled-10, 64 kDa Embryonic and adult tissue Wnt CD49a VLA-1, ITGA1, 180 kDa T cells, endothelial cells Adhesion, complex with CD29 Collagen, laminin Sdc1 kDa pre-B cells, neurons kDa erythrocytes, embryonic receptor Activation of the Wnt/β-catenin pathway; integrin α1 Fzd10 regulation of tissue and cell polarity CD140a PDGFRα 180 kDa Fibroblasts, smooth muscle, Embryonic development, signaling PDGF-A, PDGF-B, CD235a , 36 kDa Erythrocytes – – CD49b VLA-2, ITGA2, 165 kDa Platelets, T cell subsets, Adhesion, complex with CD29 Collagen, laminin glial cells, chondrocytes PDGF-C Gypa CD351 FCAMR 70 kDa Oligodendrocytes, B cells, – IgM, IgA integrin α2 megakaryocytes, NK cells macrophages, T cells, Tact cells CD140b PDGFRβ 180 kDa Fibroblasts, smooth muscle cells, Signaling PDGF-B CD238 Kell blood group, 110 kDa Erythrocytes; mRNA: spleen – – CD49c VLA-3, ITGA3, 125 kDa B cell subsets, Tlow cells Adhesion, complex with CD29 Laminin, fibronectin, glial cells, chondrocytes Kel CD352 SLAMF6, Ly108, 60 kDa T, B, and NK cells Enhances NK cell activity – integrin α3 collagen NTB-A CD141 , 100 kDa Monocytes, neutrophils, endothelial Initiation of protein C anticoagulant pathway Thrombin CD239 B-CAM, Lu 78–85 mRNA: broad, erythrocytes Lutheran blood group, B adhesion to laminin Laminin α5 chain CD49d VLA-4, ITGA4, 150 kDa T cells, B cells, monocytes Adhesion, complex with CD29 or β7 Fibronectin, CD106, Thbd cells, smooth muscle kDa CD353 SLAMF8, Blame – Evidence at the transcript level Possible role in B-lineage commitment or – integrin α4 MAdCAM modulation of BCR signaling CD142 , 45 kDa Embryonic development – Clotting factor VIIa CD241 Rh 50, 50 kDa Erythrocytes Rh antigens with CD47 and LW CD11a/CD18; CD49e VLA-5, ITGA5, 135 kDa Thymocytes, Tact cells, splenic B cells Adhesion, complex with CD29 Fibronectin factor III, F3 RhAg CD11b/CD18; CD51; CD354 TREM1 30 kDa Monocytes, DCs, macrophage Innate immune response to infection Necl-2 integrin α5 β1 and β5 integrins subsets, platelets, megakaryocytes, CD143 ACE (angiotensin 170 kDa Endothelial cells Peptidyl-peptidase, angiotensin-converting Angiotensin I, microglia, hepatocytes, osteoclasts CD49f VLA-6, ITGA6, 120 kDa Memory T cells, thymocytes, platelets Adhesion, complex with CD29 Laminin converting enzyme bradykinin CD242 ICAM-4, 42 kDa RNA: broad Adhesion, Landsteiner-Wiener blood group – integrin α6 enzyme) LW blood group CD355 Class-I MHC- 70 kDa NKact cells, CD8 Tact cells Adhesion – restricted T-cell CD50 ICAM5, Ticn, 130 kDa Brain, dopaminergic neurons Adhesion CD11a/CD18 CD144 Cadherin-5, 130 kDa Endothelial cells Adhesion, intercellular interaction Homotypic binding CD243 MDR-1, Abcb1, 170 kDa T cell subsets, stem cells, small Ion pump, cytokine export, CTL function CD48 associated telencephalin VE-cadherin to CD144 P-gp intestine, kidney molecule CD51 Vitronectin 125, 24 Platelets, megakaryocytes, endothelial Adhesion, complex with CD61 Vitronectin, CD146 MUC18, S-endo, 130 kDa Embryonic tissue, mammary tumors Adhesion during development – CD244 2B4, Ly-90, 78 kDa NK cells, NKT cells, lymphokine- NK cell activation, CD48 receptor, MHC- – (CRTAM) receptor, Itgav, kDa cells, osteoblasts vWF, fibrinogen, mcom Nmrk activated killer cells, strain-specific unrestricted killing CD357 TNFRSF18, Gitr 66–70 Tact and Treg cells Participation in dominant immunological TNFSF18 integrin αv thrombospondin act isoforms CD244.1 (in BALB/c) and kDa self-tolerance CD147 Neurothelin, 55–65 Leukocytes , erythrocytes, platelets, Adhesion, blood-brain barrier – CD244.2 (C57/Bl6) CD52 CAMPATH-1, 12 kDa Mature lymphocytes, Treg cell subsets – – , Bsg kDa endothelial cells CD358 TNFRSF21, Dr6 – Hematopoietic and nonhematopoietic Apoptosis APP MB7, CLS1 CD246 ALK 200 kDa mRNA: brain; not normal lymphocytes Anaplastic lymphoma kinase, brain – cells; tumor cells CD148 PTPRJ, PTP-eta 240– Broad in hematopoietic cells, Role in B cell signaling – development CD53 OX-44 35–42 Leukocytes, DCs, osteoblasts, Signaling – 260 endothelial cells CD360 IL-21R, Nilr 60 kDa T cells, B cells, NK cells, DCs Complex with CD132, activation, IL-21 kDa osteoclasts kDa CD247 TCR zeta, 16 kDa T cells, NK cell subsets TCR subunit, signaling, low-level impaired – proliferation, development, apoptosis CD3 ε immune function CD54 ICAM-1, Ly-47 85–110 Endothelial cells, monocytes, resting Adhesion, T cell co-stimulation CD11a/CD18, CD150 SLAM, IPO-3 75 kDa T cells, B cells, hematopoietic stem Co-stimulation, proliferation, Ig production CD150 CD361 EVI2B – Widely expressed in hematopoietic – – kDa lymphocytes (high on activation) CD11b/CD18, CD43 cell subsets CD248 TEM1, endosialin 175 kDa Endothelial cells tissue May function in tumor progression and – cells angiogenesis CD55 Decay 60–70 Broad, induced in uterus by estrogen Similar to Crry, protection from autologous C3b, C4, CD97 CD151 PETA-3, SFA-1 32 kDa Endothelial cells, megakaryocytes, Adhesion, signaling – CD362 Syndecan-2, 25 kDa Epithelial cells, neuronal cells, Adhesion, migration FGFb accelerating kDa complement attack platelets CD252 OX-40 ligand, 35 kDa Bact cells, cardiac myocytes T and B cell interaction, CD134 SDC2, HSPG1, mesenchymal cells factor gp34 T cell co-stimulation CD152 CTLA-4, Ly-56 33 kDa Tact cells, B cell subset, Treg Negative T cell stimulation CD80, CD86 SYND2 CD56 NCAM 20–185 Neural tissue, multiple isoforms; not Adhesion, neuron development, skeletal Heparan sulfate act act act CD253 TRAIL, APO-2L – NK cells, liver NK cells Apoptosis CD261, CD262, CD363 Sphingosine- 40 kDa Lymphocytes, endothelial cells, Adhesion, migration, cytoskeletal S1P kDa on mouse NK cells myogenesis CD153 CD30L, 40 kDa T cells, macrophages , neutrophils, T cell co-stimulation CD30 CD263, CD264 TNFRSF8 B cells, induced on cardiac myocyte 1-phosphate monocytes/macrophages, neural cells organization CD57 B3GAT1, HNK-1 38 kDa RNA cloned Adhesion molecule, memory – act receptor 1 act CD254 TRANCE, 35 kDa T cells, osteoblasts T cell and DC communication, osteoclast CD265, OPG CD154 CD40L, gp39, 32–39 Transiently on T cells, B cell subsets B cell and DC co-stimulation, T cell CD40 RANKL, OPGL differentiation, T and B cell interaction (S1PR1), EDG1, CD59 Protectin, MAC- 19 kDa Broad Blocking of membrane attack C8, C9 Ly-62, TNFRSF5 kDa (intracellular), platelets, macrophages, activation Lpb1 inhibitor complex assembly DCs CD256 APRIL, TALL-2 16 kDa Tact cells, monocytes, macrophages Stimulates T and B cell proliferation CD267, CD269 CD364 PI16, peptidase 49 kDa T cell subsets (Treg and memory) Putative serine protease inhibitor – CD61 GPIIIa, integrin 105 kDa Platelets, megakaryocytes, Complex with CD41 or CD51, adhesion Vitronectin, CD155 PVR 80–90 Broad hematopoietic, epithelial Adhesion, induce cytotoxicity Polio virus, CD96, CD257 BLyS, BAFF, 45 kDa Monocytes, broader expression upon Induces B cell proliferation CD267, CD269, inhibitor 16, β3, ITGB3 macrophages, endothelial cells fibronectin, vWF, kDa CD226 TA LL-1 stimulation CD268 MSMBBP fibrinogen act + CD156a ADAM8, MS2 69 kDa Neutrophils, monocytes Metalloprotease, leukocyte extravasation – CD258 LIGHT, HVEM-L 28 kDa T cells, immature DCs, may be Induces T cell proliferation, also binds HVEM CD270, LTβR CD365 TIM-1, HAVCR1, 38 kDa Activated CD4 T cells, B cell subset Role in T-helper cell development, involved in Hepatitis A virus, CD62E E-, 107– Endothelial cells Leukocyte rolling and migration; tumor Sialyl Lewis X, ESL- intracellular HAVCR-1, TIMD1 hepatitis A virus entry into cells phosphatidylserine, ELAM-1, Sele 97 115 metastasis 1, CD162 CD156b TACE/ADAM 17 100 kDa Broad Zinc metalloprotease, – TIM4, IgA kDa TNF-converting enzyme CD262 TRAIL-R2, DR5, – Broad expression Activates NF-κB and mediates apoptosis, CD253 Apo2, TRICK2, p53-dependent expression CD366 TIM-3, HAVCR2, 33 kDa Th1 cells Inhibitory receptor on Th1 cells – CD62L L-selectin, 74 and B cells, T cells, monocytes, Lymphocyte homing; leukocyte tethering CD34, CD57, CD156c ADAM10, kuz, 60 kDa Neural precursors, fibroblasts Proteolytic cleavage of cell-surface – KILLER TIMD3 LECAM-1, SELL 95 kDa granulocytes, NK cells, thymocytes and rolling CD162, GlyCAM-1, kuzbanian, molecules including Notch, TNFα, APP, and MAdCAM-1 Madm ephrin-A2 CD265 RANK, 97 kDa Broad expression Binding mediates osteoclastogenesis and CD254 CD367 CLEC4A, DCIR, 27 kDa B cells, monocytes, granulocytes, Inhibitory receptor on DCs and B cells – TRANCE-R, T cell and DC interactions DDB27, CLECSF6 plasmacytoid DCs, monocyte DCs CD62P P-selectin, SELP 140 kDa Plateletsact, endothelial cells Adhesion, neutrophil rolling, platelet- CD162, sialyl CD157 BST-1, Ly-65, 38–48 Endothelial cells, myeloid cells, early ADP-ribosyl cyclase and ADP-ribose Fibronectin ODFR neutrophil, binds to CD24 Lewis X Bp3 kDa B cells, T cell subsets, bone marrow hydrolase, pre-B growth CD368 CLEC4D, MCL, 24 kDa Monocytes, macrophages Endocytic receptor – stroma CD266 TWEAK receptor, 14 kDa mRNA in liver regeneration Cell migration, proliferation, angiogenesis, CD255 CLECSF8, CLEC- CD63 MLA1, LAMP3, 53 kDa Granulocytes, B cells, platelets, Lysosomal membrane protein, translocates – Fn14 activates NF-κB pathway 6, MPCL DC-LAMP, nonhematopoietic tissue, basophilsact, to surface upon activation CD159a NKG2A, Klrc1 43 kDa NK and NKT cells With CD94, inhibitory signaling Qa-1 TSPAN30 and platelets CD267 TACI, 32 kDa Tact cells, B cells Stimulates B and T cell function CD256, CD257 CD369 CLEC7A, 27 kDa Monocytes, macrophages, DCs, Lectin, necessary for TLR2-mediated – CD159c NKG2C – NK and NKT cells With CD94, stimulatory signaling Qa-1 TNFRSF13b DECTIN-1, neutrophils, lymphocyteslow inflammatory response CD64 FcγRI 72 kDa Monocytes, macrophages, DCs, High-affinity IgG receptor, phagocytosis, IgG CD160 BY55 27 kDa NK cells, intestinal intraepithelial Co-stimulation, NK cell activation Classical and non- CLECSF12, granulocytesact trypsin sensitive, ADCC CD268 BAFFR, Bcmd 25 kDa B cells, Tact cell subsets Promotes survival of mature B cells and CD257 lymphocyte subsets, T cell subset classical MHC class I B cell response CD370 CLEC9A, 27 kDa DCs (conventional DCs, plasmacytoid DCs) Endocytic receptor – CD66a Ceacam1, 140– Epithelial cells, endothelial cells, Cell–cell interaction, hepatitis virus receptor MHV S1 spike HEEE9341, CD161a Klrb1a, Ly55, – Evidence at the transcript level Stimulation of NK cells – CD269 BCMA, 35 kDa Mature B cells (membrane and Survival and proliferation CD256, CD257 C-Cam 180 B cells, NK cell subsets, monocytes, glycoprotein Ly55a, Nkrp1a UNQ9341, DNGR1 kDa DCs, granulocytes TNFRSF17 perinuclear) CD371 CLEC12A, CLL-1, 30 kDa Neutrophils, eosinophils, monocytes, Signal transduction – CD161b Klrb1b, Ly55b, 40 kDa NK and NKT cells Inhibition of NK cytotoxicity Clec2D CD270 TNFRSF14, 30 kDa T cells, monocytes, DCs, B cells, Stimulatory and inhibitory signaling CD258, CD272, CD68 Macrosialin, 87–115 Predominantly intracellular, tissue Lysosomal-associated protein, phagocytosis Oxidized LDL Nkrp1b MICL, DCA L-2 DC subset GP110 kDa macrophages, low expression in DCs HVEM neutrophils HSV-1, HSV-2 CD161c NKR-P1c, Ly‑55, 40 kDa NK cells, T cell subset of NK1.1 strains NK cell–mediated cytotoxicity – act act act CD271 NGFR, 45 kDa Neurons, neural crest stem cells, Tumor suppressor–mediated cell survival NGF, BDNF, NT-3, CD69 Activation 35–39 T cells, B cells, NK cells, Early activation marker, thymocyte – NK1.1 inducer kDa granulocytesact, thymocytes, platelets development TNFRSF16, mesenchymal stem/stromal cells, and death NT-4 molecule, VEA CD162 PSGL-1, Slp1 120 kDa Bone marrow DCs, mast cells, many Adhesion, leukocyte rolling CD62P, CD62E, p75(NTR), Bex3, melanocytes, astrocytes, oligodendro- Abbreviations leukocytes; high on T cells CD62L Ngfrap1 cytes, subset of lymphoid cells CD70 Ki-24, TNFRSF7 50, 70, Bact cells, Tact cells, cardiac myocytes T and B cell co-stimulation CD27 including follicular dendritic cells 90, 160 CD163 Scavenger 100– Peritoneal macrophages, Breaks down hemoglobin complexes, Oxidized hemoglobin DC: dendritic cell MHC: major histocompatibility complex kDa receptor 130 M2 macrophage adhesion CD272 B and T 33 kDa T cells, B cells, bone marrow, splenic Negative regulation CD270, LTβR cysteine-rich kDa lymphocyte macrophages, bone marrow–derived NKT: natural killer T AML: acute myeloid leukemia CD71 T9, TrfR 95 kDa Proliferating cells, reticulocytes, Iron uptake, cell activation Transferrin type 1 protein attenuator DCs erythroid precursors M30 (BTLA) Th: T helper HA: hemagglutinin CD72 Lyb-2 40–45 B cells, follicular DCs, T cell subsets B cell co-stimulation CD100, CD5 CD164 MGC-24, A115, 80 kDa mRNA: broad expression from various Hematopoietic progenitor–stroma interaction – CD273 B7DC, PD-L2, 25 kDa DC subsets, monocytes, macrophages Co-stimulation or suppression of CD279 kDa A24 adult and embryonic tissues PDCD1L2 T cell proliferation Treg: regulatory T TCR: T cell receptor + CD73 Nt5e 69 kDa Treg cells, CD4 T cells, myeloid BM Ecto-5´-nucleotidase, T cell co-stimulation, – act CD274 B7-H1, PD-L1, 33 kDa Leukocytes, decrease in mature Proliferation and cytokine production CD279 CD166 ALCAM 105 kDa T cells, monocytes, epithelial cells, Adhesion, T cell development, T and B CD6 PBMC: peripheral blood mononuclear cell BCR: B cell receptor adhesion fibroblasts, Bact cells cell interaction, role in nervous system, PDCD1LG1 thymic T, B, NK, and dendritic cells pluripotent stem cell marker CD74 Ii, Ia-invariant 33–43 B cells, macrophages, monocytes MHC class II traffic and function, – CD275 B7-H2, GL50, 40 kDa Antigen-presenting cells, B cells, Lymphocyte co-stimulation CD278 HSC: hematopoietic stem cell chain kDa antigen presentation CD167a DDR1 120 kDa Epithelial cells, myoblasts, brain, early Discoidin domain receptor, tyrosine kinase, Collagen ICOS-L, B7h, DCs, macrophages B7RP-1 CD79a Igα, MB-1, 33, 45 B cells BCR subunit; BCR expression and signaling – marker neuroectoderma adhesion Ly-54 kDa CD168 RHAMM, 70–73 Broad, high on B cells Adhesion, cell locomotion, tumor metastasis Hyaluronan CD276 B7-H3, B7RP-2 40–45 In vitro–cultured DCs and monocytes, Negative regulator of T cell activation – hyaluronan- kDa kDa antigen-presenting cells, developing CD79b Igβ, B29 37 kDa B cells BCR subunit; BCR expression and signaling – mediated bone CD80 B7, B7-1, Ly-53 60 kDa Bact cells, Tact cells, monocytes, Co-stimulation, T and B cell interaction CD28, CD152 motility receptor macrophages, DCs, pancreatic β cells (HMMR)

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