Supplementary table 1 Detailed information about the in the prostate cancer & benign tissue (P & b) group The Differentially reported symbol name expressed frequency 7 DES1-7 Down-regulation 4 ANXA53,5,8,9 Up-regulation 4 ENO13,8,10,11 enlace 1, (alpha) Up-regulation heat shock 60kDa protein 1 4 HSPD11,3,4,11 Up-regulation (chaperonin) serpin peptidase inhibitor, clade F SERPINF13,6,12,1 4 (alpha-2 antiplasmin, pigment 1 Up, 2 Down 3 derived factor), member 1 4 VCL1,3,7,14 1 Up, 2 Down 3 ACPP3,6,11 acid phosphatase, prostate Up-regulation 3 ANXA33,7,9 annexin A3 Up-regulation 3 AZGP13,6,12 alpha-2- 1, -binding Up-regulation 3 FGG3,4,15 gamma chain 1 Up, 1 Down 3 GSN1,3,15 2 Up, 1 Down 3 GSTP13,10,14 glutathione S- pi 1 1 Up, 1 Down 3 HSPA51,3,4 heat shock 70kDa protein 5 Up-regulation 3 KRT83,4,7 8 1 Up, 1 Down 3 PHB3,4,6 prohibitin Up-regulation 3 POSTN1,6,16 periostin, osteoblast specific factor Up-regulation serpin peptidase inhibitor, clade C 3 SERPINC13,12,17 1 Up, 1 Down (antithrombin), member 1 3 TPD521,3,17 tumor protein D52 Up-regulation 3 TPM12,5,7 1 (alpha) 1 Up, 1 Down 3 TUBB4B3,4,6 , beta 4B class IVb Up-regulation v-akt murine thymoma viral oncogene 2 AKT19,10 - homolog 1 2 ALDOA11,16 aldolase A, -bisphosphate Up-regulation 2 AMACR6,13 alpha-methylacyl-CoA racemase Up-regulation 2 ANXA13,9 Up-regulation 2 ANXA73,7 annexin A7 Up-regulation 2 APCS7,16 P component, serum Up-regulation 2 APOA14,15 apolipoprotein A-I Down-regulation Rho GDP dissociation inhibitor (GDI) 2 ARHGDIA3,4 Up-regulation alpha ATP synthase, H+ transporting, 2 ATP5B4,6 mitochondrial F1 complex, beta Down-regulation polypeptide 2 B2M6,18 beta-2-microglobulin Up-regulation capping protein ( filament), 2 CAPG3,14 Down-regulation gelsolin-like 2 CAV19,13 1, protein, 22kDa Down-regulation 2 CKB4,5 creatine kinase, brain Down-regulation crystallin, zeta (quinone reductase)-like 2 CRYZL115,17 Up-regulation 1 dimethylarginine 2 DDAH13,9 Up-regulation dimethylaminohydrolase 1 2 ENDOD115,17 endonuclease domain containing 1 Up-regulation 2 EZR3,6 ezrin Up-regulation 2 F212,19 coagulation factor II () 1 Up, 1 Down 2 FGB3,19 fibrinogen beta chain 1 Up, 1 Down 2 FKBP43,8 FK506 binding protein 4, 59kDa 1 Up, 1 Down folate (prostate-specific 2 FOLH16,13 Up-regulation membrane antigen) 1 group-specific component (vitamin D 2 GC3,15 1 Up, 1 Down binding protein) 2 GSTM33,14 glutathione S-transferase mu 3 (brain) Up-regulation heterogeneous nuclear 2 HNRNPH11,3 Up-regulation ribonucleoprotein H1 (H) heterogeneous nuclear 2 HNRNPK3,7 Up-regulation ribonucleoprotein K 2 HP12,15 Down-regulation heat shock protein 90kDa alpha 2 HSP90AA13,16 Up-regulation (cytosolic), class A member 1 2 HSPA84,6 heat shock 70kDa protein 8 Down-regulation 2 HSPA91,4 heat shock 70kDa protein 9 (mortalin) Up-regulation 2 HSPB11,3 heat shock 27kDa protein 1 1 Up, 1 Down 2 HSPG21,15 2 1 Up, 1 Down 2 ILF215,17 interleukin enhancer binding factor 2 Up-regulation 2 KRT183,4 Up-regulation 2 KRT193,4 Up-regulation 2 KRT26,7 keratin 2 - 2 KRT52,13 Down-regulation 2 LDHA11,16 lactate A Up-regulation methylcrotonoyl-CoA carboxylase 2 2 MCCC26,14 Up-regulation (beta) 2 OGN1,16 Down-regulation 2 P4HB3,4 prolyl 4-hydroxylase, beta polypeptide Up-regulation protein disulfide family A, 2 PDIA31,7 Up-regulation member 3 2 PGAM110,11 phosphoglycerate mutase 1 Up-regulation 2 PSME13,16 proteasome (prosome, macropain) Up-regulation activator subunit 1 (PA28 alpha) proteasome (prosome, macropain) 2 PSME23,16 Up-regulation activator subunit 2 (PA28 beta) prostaglandin D2 synthase 21kDa 2 PTGDS15,19 1 Up, 1 Down (brain) ring finger and FYVE-like domain 2 RFFL15,17 Up-regulation containing E3 ubiquitin protein 2 S100A92,6 S100 calcium binding protein A9 Up-regulation serpin peptidase inhibitor, clade A 2 SERPINA14,15 (alpha-1 antiproteinase, antitrypsin), Down-regulation member 1 serpin peptidase inhibitor, clade G (C1 2 SERPING16,19 Down-regulation inhibitor), member 1 2 TF15,19 1 Up, 1 Down 2 TGM22,3 transglutaminase 2 Up-regulation 2 THY16,9 Thy-1 cell surface antigen Up-regulation 2 TPM24,7 tropomyosin 2 (beta) - 2 TYMP15,17 thymidine Down-regulation 2 UMOD6,15 uromodulin Down-regulation 2 VIM1,5 Down-regulation tyrosine 3-monooxygenase/tryptophan 2 YWHAQ6,9 5-monooxygenase activation protein, - theta 1 A1BG5 alpha-1-B glycoprotein Up-regulation 1 A2ML16 alpha-2-macroglobulin-like 1 - ABL proto-oncogene 1, non-receptor 1 ABL16 - tyrosine kinase 1 ACLY14 ATP citrate Up-regulation 1 ACTC13 actin, alpha, cardiac muscle 1 Up-regulation 1 ACTG21 actin, gamma 2, smooth muscle, enteric Down-regulation 1 ACTN13 , alpha 1 Up-regulation 1 ADM26 adrenomedullin 2 - 1 AFM6 afamin - 1 AGR213 anterior gradient 2 Up-regulation 1 AHNAK1 AHNAK nucleoprotein Down-regulation 1 AHSG6 alpha-2-HS-glycoprotein - 1 ALB4 albumin - 1 ALDH23 aldehyde dehydrogenase 2 family Up-regulation aldehyde dehydrogenase 9 family, 1 ALDH9A13 Up-regulation member A1 1 AMBP15 alpha-1-microglobulin/bikunin precursor Up-regulation 1 AMY1A17 amylase, alpha 1A - 1 ANXA117 annexin A11 - 1 ANXA211 - 1 ANXA44 annexin A4 - 1 AR6 androgen receptor - 1 ARHGAP13 Rho GTPase activating protein 1 Up-regulation ATP synthase, H+ transporting, 1 ATP5A11 mitochondrial F1 complex, alpha subunit Up-regulation 1, cardiac muscle ATP synthase, H+ transporting, 1 ATP5C111 mitochondrial F1 complex, gamma Up-regulation polypeptide 1 ATPase, H+ transporting, lysosomal 1 ATP6V1B23 Up-regulation 56/58kDa, V1 subunit B2 1 AZU116 azurocidin 1 Down-regulation 1 BECN110 beclin 1, autophagy related Down-regulation 1 BGN1 Up-regulation 1 BPIFB116 BPI fold containing family B, member 1 Up-regulation 1 BSG20 (Ok group) Up-regulation 1 C312 Up-regulation 1 C4A6 complement component 4A - 1 C4B12 Up-regulation 1 C56 - 1 CALD15 caldesmon 1 Down-regulation cullin-associated and 1 CAND116 Up-regulation neddylation-dissociated 1 capping protein (actin filament) muscle 1 CAPZA13 Up-regulation Z-line, alpha 1 1 CCND213 cyclin D2 Down-regulation 1 CCR69 chemokine (C-C motif) receptor 6 Up-regulation 1 CD149 CD14 molecule Up-regulation 1 CD15120 CD151 molecule (Raph blood group) Up-regulation 1 CD2769 CD276 molecule - CD59 molecule, complement regulatory 1 CD5915 Up-regulation protein 1 CDCP120 CUB domain containing protein 1 Up-regulation cadherin 1, type 1, E-cadherin 1 CDH116 Up-regulation (epithelial) 1 CFB6 - 1 CFL18 cofilin 1 (non-muscle) Up-regulation chromogranin A (parathyroid secretory 1 CHGA6 - protein 1) 1 CHMP4B2 charged multivesicular body protein 4B Up-regulation 1 CLDN313 claudin 3 Up-regulation 1 CLIC13 chloride intracellular channel 1 Up-regulation 1 CLU1 Down-regulation CNDP dipeptidase 2 (metallopeptidase 1 CNDP23 Up-regulation M20 family) 1 CNN11 , basic, smooth muscle Down-regulation 1 COL14A15 collagen, type XIV, alpha 1 Up-regulation 1 COL1A11 collagen, type I, alpha 1 Down-regulation 1 COL6A11 collagen, type VI, alpha 1 Down-regulation 1 COL6A23 collagen, type VI, alpha 2 Up-regulation 1 COL6A31 collagen, type VI, alpha 3 Down-regulation 1 COPS88 COP9 signalosome subunit 8 Up-regulation 1 COX5B1 cytochrome c oxidase subunit Vb Up-regulation 1 COX6C1 cytochrome c oxidase subunit VIc Up-regulation 1 CP6 (ferroxidase) - 1 CPB216 carboxypeptidase B2 (plasma) Up-regulation 1 CPN116 carboxypeptidase N, polypeptide 1 Up-regulation 1 CRABP16 cellular retinoic acid binding protein 1 - v-crk avian sarcoma virus CT10 1 CRKL8 Down-regulation oncogene homolog-like 1 CRP6 C-reactive protein, pentraxin-related - 1 CS11 citrate synthase Up-regulation 1 CXCL166 chemokine (C-X-C motif) ligand 16 - 1 DCN1 Down-regulation dimethylarginine 1 DDAH27 - dimethylaminohydrolase 2 1 DDH210 Developmental dysplasia of the hip 2 - dickkopf 1 DKK113 Down-regulation inhibitor 1 dickkopf WNT signaling pathway 1 DKK36 - inhibitor 3 1 DSG116 desmoglein 1 Down-regulation 1 DSP16 Down-regulation enoyl CoA hydratase, short chain, 1, 1 ECHS14 Up-regulation mitochondrial eukaryotic translation 1 EEF1A16 - 1 alpha 1 1 EFS13 embryonal Fyn-associated substrate Down-regulation 1 EGFR6 epidermal receptor - 1 EHD21 EH-domain containing 2 Up-regulation 1 EN26 engrailed homeobox 2 - 1 ENO23 enolase 2 (gamma, neuronal) Up-regulation 1 EPHA26 EPH receptor A2 - 1 ERBB26 erb-b2 receptor tyrosine kinase 2 - 1 ERG13 v-ets avian erythroblastosis virus E26 Up-regulation oncogene homolog enhancer of zeste 2 polycomb 1 EZH26 - repressive complex 2 subunit 1 FABP56 fatty acid binding protein 5 - 1 FASN13 fatty acid synthase Up-regulation 1 FDPS3 farnesyl diphosphate synthase Up-regulation 1 FGA15 fibrinogen alpha chain Up-regulation 1 FLNC13 C, gamma Down-regulation 1 FLOT111 flotillin 1 - 1 FN16 fibronectin 1 - 1 FST6 follistatin - 1 FTH12 , heavy polypeptide 1 Up-regulation 1 FTL3 ferritin, light polypeptide Up-regulation 1 GDF156 growth differentiation factor 15 - 1 GDI23 GDP dissociation inhibitor 2 Up-regulation 1 GLO13 glyoxalase I Up-regulation binding protein (G 1 GNAI23 protein), alpha inhibiting activity Up-regulation polypeptide 2 1 GSTO13 glutathione S-transferase omega 1 Up-regulation 1 GUCY1A313 guanylate cyclase 1, soluble, alpha 3 Up-regulation hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA 1 HADHA6 - thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit HECT and RLD domain containing E3 1 HERC219 Down-regulation ubiquitin protein ligase 2 1 HGFAC16 HGF activator Up-regulation 1 HIST2H2BF2 histone cluster 2, H2bf Down-regulation heterogeneous nuclear 1 HNRNPA2B15 Down-regulation ribonucleoprotein A2/B1 heterogeneous nuclear 1 HNRNPL14 Up-regulation ribonucleoprotein L heterochromatin protein 1, binding 1 HP1BP31 Up-regulation protein 3 1 HPN13 hepsin Up-regulation 1 HPX12 Down-regulation 1 HRNR8 hornerin Up-regulation heat shock protein 90kDa alpha 1 HSP90AB116 Up-regulation (cytosolic), class B member 1 heat shock protein 90kDa beta (Grp94), 1 HSP90B16 - member 1 1 HSPA1A4 heat shock 70kDa protein 1A - 1 HSPA1B3 heat shock 70kDa protein 1B Up-regulation 1 HYPK8 huntingtin interacting protein K Down-regulation 2 (NADP+), 1 IDH211 Up-regulation mitochondrial insulin-like growth factor 1 1 IGF116 Up-regulation (somatomedin C) 1 IGHA119 immunoglobulin heavy constant alpha 1 Down-regulation 1 IGHV4-3119 immunoglobulin heavy variable 4-31 Down-regulation 1 IGL1 immunoglobulin lambda Down-regulation 1 IL66 interleukin 6 - IMP (inosine 5'-monophosphate) 1 IMPDH214 Up-regulation dehydrogenase 2 inter-alpha- inhibitor heavy chain 1 ITIH415 Up-regulation family, member 4 1 JAK26 Janus kinase 2 - 1 JUP16 junction Down-regulation 1 KHSRP8 KH-type splicing regulatory protein Up-regulation 1 KRT13 Up-regulation 3

1 KRT10 Up-regulation 1 KRT1514 Down-regulation 1 LAMC11 laminin, gamma 1 Down-regulation lymphocyte cytosolic protein 1 1 LCP116 Up-regulation (L-plastin) 1 LDHB16 B Up-regulation 1 LIMA16 LIM domain and actin binding 1 - 1 LMAN215 lectin, -binding 2 Up-regulation 1 LMNA6 A/C - LIM domain containing preferred 1 LPP1 Down-regulation translocation partner in lipoma 1 LRG16 leucine-rich alpha-2-glycoprotein 1 - 1 LUM16 Up-regulation 1 MACF119 -actin crosslinking factor 1 Down-regulation mannan-binding lectin serine peptidase 1 MASP215 Up-regulation 2 2, NAD 1 MDH211 Up-regulation (mitochondrial) 1 MMRN116 multimerin 1 Down-regulation 1 MPO19 myeloperoxidase Down-regulation 1 MSN14 moesin Down-regulation 1 MUC318 intestinal -like Up-regulation , light chain 6, alkali, smooth 1 MYL68 Down-regulation muscle and non-muscle 1 MYL914 myosin, light chain 9, regulatory Down-regulation 1 NDRG13 N-myc downstream regulated 1 Up-regulation NADH dehydrogenase (ubiquinone) 1 NDUFS13 Fe-S protein 1, 75kDa Up-regulation (NADH-coenzyme Q reductase) nucleophosmin (nucleolar 1 NPM11 Up-regulation phosphoprotein B23, numatrin) 1 NRP120 neuropilin 1 Up-regulation 1 NUP1073 nucleoporin 107kDa Up-regulation 1 OSTF18 osteoclast stimulating factor 1 Up-regulation 1 PARK73 parkinson protein 7 Up-regulation pyruvate dehydrogenase (lipoamide) 1 PDHB8 Down-regulation beta protein disulfide isomerase family A, 1 PDIA41 Up-regulation member 4 protein disulfide isomerase family A, 1 PDIA63 Up-regulation member 6 pyridoxal (pyridoxine, vitamin B6) 1 PDXK3 Up-regulation kinase phosphatidylethanolamine binding 1 PEBP11 Down-regulation protein 1 1 PFDN58 prefoldin subunit 5 Up-regulation 1 PGA318 pepsinogen 3, group I (pepsinogen A) Up-regulation 1 PGC6 progastricsin (pepsinogen C) - 1 PHB21 prohibitin 2 Up-regulation 1 PKM9 pyruvate kinase, muscle - 1 PLS316 plastin 3 Up-regulation 1 PON316 paraoxonase 3 Up-regulation 1 PPA26 (inorganic) 2 - 1 PRDX110 peroxiredoxin 1 - 1 PRDX27 peroxiredoxin 2 - 1 PRDX38 peroxiredoxin 3 Down-regulation 1 PRDX67 peroxiredoxin 6 - 1 PRKCDBP1 protein kinase C, delta binding protein Down-regulation proteasome (prosome, macropain) 26S 1 PSMC511 - subunit, ATPase, 5 1 PTEN6 phosphatase and tensin homolog - 1 PTX36 pentraxin 3, long - 1 PYGB14 phosphorylase, glycogen; brain Down-regulation 1 RAB3617 RAB36, member RAS oncogene family - 13

1 RND3 Rho family GTPase 3 Down-regulation 1 RPLP08 ribosomal protein, large, P0 Up-regulation 1 RPS81 ribosomal protein S8 Up-regulation 1 SAA112 serum amyloid A1 Down-regulation 1 SAA416 serum amyloid A4, constitutive Up-regulation 1 SBSN16 suprabasin Down-regulation 1 SCFV19 single-chain Fv fragment Down-regulation 1 SDPR1 serum deprivation response Down-regulation 1 SECTM115 secreted and transmembrane 1 Up-regulation 1 SELENBP17 selenium binding protein 1 - 1 SEMG16 semenogelin I - serpin peptidase inhibitor, clade A 1 SERPINA36 (alpha-1 antiproteinase, antitrypsin), - member 3 serpin peptidase inhibitor, clade A 1 SERPINA513 (alpha-1 antiproteinase, antitrypsin), Down-regulation member 5 serpin peptidase inhibitor, clade B 1 SERPINB514 Down-regulation (ovalbumin), member 5 serpin peptidase inhibitor, clade E 1 SERPINE13 (nexin, plasminogen activator inhibitor Up-regulation type 1), member 1 1 SFTPB16 surfactant protein B Up-regulation single-minded family bHLH transcription 1 SIM213 Up-regulation factor 2 synuclein, gamma (breast 1 SNCG13 Down-regulation cancer-specific protein 1) small nuclear ribonucleoprotein 200kDa 1 SNRNP2004 - (U5) 1 SORBS11 sorbin and SH3 domain containing 1 Down-regulation 1

1 SORBS2 sorbin and SH3 domain containing 2 Down-regulation 1 SORD1 dehydrogenase Up-regulation 1 SOX46 SRY (sex determining region Y)-box 4 - 1 SPON26 spondin 2, extracellular matrix protein - 1 SPP119 secreted phosphoprotein 1 Down-regulation SRC proto-oncogene, non-receptor 1 SRC6 - tyrosine kinase 1 SRSF12 serine/arginine-rich splicing factor 1 Up-regulation 1 STOML23 stomatin (EPB72)-like 2 Up-regulation serine/threonine kinase receptor 1 STRAP3 Up-regulation associated protein sushi, von Willebrand factor type A, 1 SVEP116 Down-regulation EGF and pentraxin domain containing 1 1 SYTL26 -like 2 - 1 TAGLN3 transgelin Up-regulation 1 TCP15 t-complex 1 Up-regulation 1 TFF313 trefoil factor 3 (intestinal) Up-regulation 1 TFG6 TRK-fused gene - 1 TGFB16 transforming growth factor, beta 1 - 1 THBS216 thrombospondin 2 Down-regulation 1 TIMP19 TIMP metallopeptidase inhibitor 1 Down-regulation 1 TKT11 transketolase Up-regulation 1 TLN11 1 Down-regulation transmembrane and immunoglobulin 1 TMIGD117 - domain containing 1 1 TMPRSS26 transmembrane protease, serine 2 - 1 TNC1 tenascin C Down-regulation 1 TP539 tumor protein p53 Up-regulation 1 TPI13 triosephosphate isomerase 1 Up-regulation tumor protein, translationally-controlled 1 TPT120 Up-regulation 1 1 TRAP114 TNF receptor-associated protein 1 Up-regulation 1 TTR15 transthyretin Down-regulation Tu translation elongation factor, 1 TUFM1 Up-regulation mitochondrial thioredoxin domain containing 12 1 TXNDC128 Up-regulation (endoplasmic reticulum)

1 ubiquitin-like modifier activating

1 UBA1 Up-regulation 1 ubiquitin carboxyl-terminal esterase L1 1 UCHL110 - (ubiquitin thiolesterase) ubiquinol-cytochrome c reductase core 1 UQCRC211 Up-regulation protein II UTP18 small subunit (SSU) 1 UTP1817 processome component homolog - (yeast) 1 WDR17 WD repeat domain 1 - X-ray repair complementing defective 1 XRCC63 Up-regulation repair in Chinese hamster cells 6 tyrosine 3-monooxygenase/tryptophan 1 YWHAB3 5-monooxygenase activation protein, Up-regulation beta tyrosine 3-monooxygenase/tryptophan 1 YWHAE3 5-monooxygenase activation protein, Up-regulation epsilon tyrosine 3-monooxygenase/tryptophan 1 YWHAG4 5-monooxygenase activation protein, - gamma tyrosine 3-monooxygenase/tryptophan 1 YWHAZ3 Up-regulation 5-monooxygenase activation protein, zeta zinc finger and BTB domain containing 1 ZBTB7A10 - 7A 1 ZYX1 Down-regulation Notes: “1 Up, 2 Down” indicates this protein was once reported as up-regulated and twice reported as down-regulated. “-” indicates literature did not provide expression information. In this table, the frequency with which proteins are reported is not consistent with the frequency of expression because some studies did not provide expression information.

Supplementary table 2 Detailed information about the proteins in the high & low metastatic tendency of prostate cancer group The Differentially reported Gene symbol Protein name expressed frequency 4 ACPP1,5,21,22 acid phosphatase, prostate 1 Up, 2 Down 4 HSPA51,4,5,23 heat shock 70kDa protein 5 3 Up, 1 Down 4 VCL1,2,5,20 vinculin 2 Up, 2 Down 3 ACTN120,24,25 actinin, alpha 1 Down-regulation 3 ANXA120,21,25 annexin A1 1 Up, 1 Down 3 AZGP122,26,27 alpha-2-glycoprotein 1, zinc-binding Up-regulation 3 COL6A25,27,28 collagen, type VI, alpha 2 1 Up, 1 Down 3 DES1,2,4 Desmin Down-regulation 3 FLNA2,5,20 filamin A, alpha Down-regulation 3 LMNA2,5,11 lamin A/C 2 Up, 1 Down malate dehydrogenase 2, NAD 3 MDH25,23,25 2 Up, 1 Down (mitochondrial) 3 MYH91,20,21 myosin, heavy chain 9, non-muscle 1 Up, 1 Down 3 TLN11,20,25 talin 1 1 Up, 1 Down 2 AHNAK1,20 AHNAK nucleoprotein Up-regulation 2 ANPEP20,25 alanyl (membrane) aminopeptidase Down-regulation 2 ANXA1120,25 annexin A11 Up-regulation 2 ANXA320,25 annexin A3 Down-regulation 2 ANXA55,20 annexin A5 Up-regulation 2 ANXA720,25 annexin A7 Up-regulation 2 ARHGDIA4,23 Rho GDP dissociation inhibitor (GDI) alpha 1 Up, 1 Down ATP synthase, H+ transporting, 2 ATP5B4,25 mitochondrial F1 complex, beta 1 Up, 1 Down polypeptide capping protein (actin filament) muscle 2 CAPZA15,20 Up-regulation Z-line, alpha 1 2 CNN11,5 calponin 1, basic, smooth muscle Down-regulation 2 COL6A12,27 collagen, type VI, alpha 1 Down-regulation 2 CTSD2,27 cathepsin D Up-regulation 2 EPHA220,28 EPH receptor A2 - 2 EZR2,20 ezrin Up-regulation 2 GLO12,23 glyoxalase I 1 Up, 1 Down 2 GSN2,5 gelsolin Down-regulation 2 HSPA1A4,20 heat shock 70kDa protein 1A Down-regulation 2 HSPA84,20 heat shock 70kDa protein 8 Down-regulation 2 HSPB12,25 heat shock 27kDa protein 1 1 Up, 1 Down 2 HSPD11,25 heat shock 60kDa protein 1 (chaperonin) Up-regulation 2 IGFBP527,28 insulin-like growth factor binding protein 5 - 2 LGALS35,27 lectin, galactoside-binding, soluble, 3 Down-regulation LGALS3BP22,2 lectin, galactoside-binding, soluble, 3 2 - 7 binding protein 2 MYL91,2 myosin, light chain 9, regulatory Down-regulation nucleophosmin (nucleolar phosphoprotein 2 NPM11,23 Up-regulation B23, numatrin) 2 NUCB125,27 nucleobindin 1 Down-regulation 2 OGN5,11 osteoglycin Up-regulation 2 P4HB4,27 prolyl 4-hydroxylase, beta polypeptide Down-regulation peptidylglycine alpha-amidating 2 PAM27,28 Up-regulation monooxygenase protein disulfide isomerase family A, 2 PDIA31,23 Up-regulation member 3 2 PRDX42,5 peroxiredoxin 4 Up-regulation serpin peptidase inhibitor, clade A (alpha-1 2 SERPINA14,27 Down-regulation antiproteinase, antitrypsin), member 1 2 SFN21,27 stratifin Down-regulation 2 TF2,21 transferrin 1 Up, 1 Down 2 TGFB227,28 transforming growth factor, beta 2 - 2 TIMP121,27 TIMP metallopeptidase inhibitor 1 Down-regulation 2 TPM320,29 Up-regulation Tu translation elongation factor, 2 TUFM1,24 Up-regulation mitochondrial 2 VDAC124,25 voltage-dependent anion channel 1 Up-regulation 1 A1BG5 alpha-1-B glycoprotein Up-regulation 1 ACP129 acid phosphatase 1, soluble Up-regulation 2

1 ACTA1 actin, alpha 1, skeletal muscle Down-regulation 1 ACTA220 actin, alpha 2, smooth muscle, aorta - 1 ACTB20 actin, beta - 1 ACTN420 actinin, alpha 4 - 1 ACTR220 ARP2 actin-related protein 2 homolog - (yeast) ADAM metallopeptidase with 1 ADAMTS121 Down-regulation thrombospondin type 1 motif, 1 1 AGRN21 agrin - v-akt murine thymoma viral oncogene 1 AKT123 Up-regulation homolog 1 1 ALB4 albumin Up-regulation aldehyde dehydrogenase 1 family, 1 ALDH1A325 Down-regulation member A3 acidic (leucine-rich) nuclear 1 ANP32A25 Down-regulation phosphoprotein 32 family, member A 1 ANXA220 annexin A2 - 1 ANXA45 annexin A4 Up-regulation 1 ANXA620 annexin A6 - 1 APEH25 acylaminoacyl-peptide hydrolase Down-regulation 1 APOC326 apolipoprotein C-III Up-regulation 1 APP27 amyloid beta (A4) precursor protein - 1 APRT23 adenine phosphoribosyltransferase Down-regulation 1 ARCN12 archain 1 Down-regulation 1 ARF320 ADP-ribosylation factor 3 - 1 ARF420 ADP-ribosylation factor 4 - 1 ARF520 ADP-ribosylation factor 5 - 1 ARF620 ADP-ribosylation factor 6 - actin related protein 2/3 complex, subunit 1 ARPC220 - 2, 34kDa actin related protein 2/3 complex, subunit 1 ARPC320 - 3, 21kDa actin related protein 2/3 complex, subunit 1 ARPC420 - 4, 20kDa actin related protein 2/3 complex, subunit 1 ARPC5L20 - 5-like 1 ASPN1 asporin Up-regulation ATPase, Na+/K+ transporting, alpha 1 1 ATP1A120 - polypeptide ATP synthase, H+ transporting, 1 ATP5H2 Up-regulation mitochondrial Fo complex, subunit d 1 B2M27 beta-2-microglobulin - 1 B3GAT328 beta-1,3-glucuronyltransferase 3 Up-regulation UDP-Gal:betaGlcNAc beta 1,4- 1 B4GALT428 Up-regulation , polypeptide 4 1 BCCIP25 BRCA2 and CDKN1A interacting protein Down-regulation 1 BGN1 biglycan Up-regulation 1 C1S27 complement component 1, s - subcomponent 1 C327 complement component 3 - 1 CALR23 Up-regulation CAP, adenylate cyclase-associated 1 CAP125 Down-regulation protein 1 (yeast) 1 CAPRIN125 cell cycle associated protein 1 Down-regulation chaperonin containing TCP1, subunit 2 1 CCT22 Up-regulation (beta) chaperonin containing TCP1, subunit 6A 1 CCT6A2 Up-regulation (zeta 1) CD59 molecule, complement regulatory 1 CD5928 Up-regulation protein 1 CDH228 cadherin 2, type 1, N-cadherin (neuronal) - 1 CFB27 complement factor B - 1 CFD27 complement (adipsin) - 1 CFL120 cofilin 1 (non-muscle) - 1 CHID128 chitinase domain containing 1 Up-regulation 1 CKB23 creatine kinase, brain Down-regulation 1 CLIC42 chloride intracellular channel 4 Up-regulation 1 CLTC20 , heavy chain (Hc) - 1 COL14A15 collagen, type XIV, alpha 1 Up-regulation 1 COL2A127 collagen, type II, alpha 1 - 1 COL6A31 collagen, type VI, alpha 3 Up-regulation 1 COMT23 catechol-O-methyltransferase Down-regulation 1 COTL120 coactosin-like F-actin binding protein 1 - 1 COX5B1 cytochrome c oxidase subunit Vb Up-regulation 1 CPE5 carboxypeptidase E Down-regulation 1 CS25 citrate synthase Up-regulation (cadherin-associated protein), 1 CTNNB120 - beta 1, 88kDa catenin (cadherin-associated protein), 1 CTNND120 - delta 1 1 CTSL27 cathepsin L - 1 CTSZ5 cathepsin Z Up-regulation 1 CUL224 cullin 2 - 1 CXCL327 chemokine (C-X-C motif) ligand 3 - 1 CYFIP120 cytoplasmic FMR1 interacting protein 1 - 1 CYR6127 cysteine-rich, angiogenic inducer, 61 - 1 (-associated 1 DAG127 - glycoprotein 1) DEAD (Asp-Glu-Ala-Asp) box 3, 1 DDX3X25 Down-regulation X-linked 1 DERL124 derlin 1 - DIP2 disco-interacting protein 2 homolog 1 DIP2B20 - B (Drosophila) 1 DPYSL32 dihydropyrimidinase-like 3 Down-regulation developmentally regulated GTP binding 1 DRG125 Up-regulation protein 1 1 DSTN20 (actin depolymerizing factor) - 1 DYNC1H120 , cytoplasmic 1, heavy chain 1 - 1 ECH12 enoyl CoA hydratase 1, peroxisomal Up-regulation enoyl CoA hydratase, short chain, 1, 1 ECHS14 Down-regulation mitochondrial EGF-like repeats and discoidin I-like 1 EDIL320 - domains 3 1 EHD120 EH-domain containing 1 - 1 EHD420 EH-domain containing 4 - eukaryotic translation initiation factor 2B, 1 EIF2B225 Down-regulation subunit 2 beta, 39kDa eukaryotic translation initiation factor 2, 1 EIF2S225 Up-regulation subunit 2 beta, 38kDa eukaryotic translation initiation factor 3, 1 EIF3A25 Up-regulation subunit A 1 EPRS23 glutamyl-prolyl-tRNA synthetase Down-regulation 1 ERP292 endoplasmic reticulum protein 29 Up-regulation 1 FABP52 fatty acid binding protein 5 Up-regulation family with sequence similarity 3, member 1 FAM3C25 Down-regulation C phenylalanyl-tRNA synthetase, alpha 1 FARSA25 Up-regulation subunit phenylalanyl-tRNA synthetase, beta 1 FARSB25 Up-regulation subunit 1 FBLN127 fibulin 1 - 1 FGA1 fibrinogen alpha chain Down-regulation 1 FGG4 fibrinogen gamma chain Down-regulation 1 FLNB20 filamin B, beta - 1 FLNC20 filamin C, gamma - 1 FN127 fibronectin 1 - folate hydrolase (prostate-specific 1 FOLH122 - membrane antigen) 1 1 FSCN120 fascin actin-bundling protein 1 - 1 FSTL127 follistatin-like 1 - 1 FTL2 ferritin, light polypeptide Up-regulation 1 FUS24 FUS RNA binding protein - 1 G6PD5 -6-phosphate dehydrogenase Down-regulation 1 GALNT227 polypeptide - N-acetylgalactosaminyltransferase 2 polypeptide 1 GALNT627 - N-acetylgalactosaminyltransferase 6 1 GBA28 glucosidase, beta, acid Up-regulation 1 GDF1527 growth differentiation factor 15 - 1 GGCT2 gamma-glutamylcyclotransferase Up-regulation 1 GLUD11 glutamate dehydrogenase 1 Up-regulation guanine nucleotide binding protein (G 1 GNAI220 protein), alpha inhibiting activity - polypeptide 2 glycerol-3-phosphate dehydrogenase 1 1 GPD14 Down-regulation (soluble) 1 GPI25 glucose-6-phosphate isomerase Down-regulation 1 GRN27 granulin - 1 GSTM22 glutathione S-transferase mu 2 (muscle) Down-regulation 1 GSTP12 glutathione S-transferase pi 1 Down-regulation 1 H1F01 H1 histone family, member 0 Down-regulation 1 HAGH5 hydroxyacylglutathione hydrolase Up-regulation 1 HEXB2 hexosaminidase B (beta polypeptide) Up-regulation 1 HMGB129 high mobility group box 1 Up-regulation heterogeneous nuclear ribonucleoprotein 1 HNRNPA323 Down-regulation A3 heterogeneous nuclear ribonucleoprotein 1 HNRNPC2 Up-regulation C (C1/C2) heterogeneous nuclear ribonucleoprotein 1 HNRNPD25 D (AU-rich element RNA binding protein 1, Up-regulation 37kDa) heterogeneous nuclear ribonucleoprotein 1 HNRNPH11 Up-regulation H1 (H) 1 HP26 haptoglobin Up-regulation 1 HPR2 haptoglobin-related protein Down-regulation heat shock protein 90kDa alpha 1 HSP90AA120 - (cytosolic), class A member 1 heat shock protein 90kDa alpha 1 HSP90AB120 - (cytosolic), class B member 1 heat shock protein 90kDa beta (Grp94), 1 HSP90B123 Up-regulation member 1 1 HSPA924 heat shock 70kDa protein 9 (mortalin) - 1 HSPE11 heat shock 10kDa protein 1 Up-regulation 1 HSPG227 heparan sulfate proteoglycan 2 - 1 HTRA128 HtrA serine peptidase 1 Up-regulation 1 ICAM128 intercellular adhesion molecule 1 - 1 IGFBP227 insulin-like growth factor binding protein 2, - 36kDa 1 IGFBP428 insulin-like growth factor binding protein 4 - 1 IGFBP627 insulin-like growth factor binding protein 6 - immunoglobulin heavy constant gamma 1 1 IGHG15 Down-regulation (G1m marker) 1 IL627 interleukin 6 - 1 IMPA12 inositol(myo)-1(or 4)-monophosphatase 1 Up-regulation 1 INHBA27 inhibin, beta A - 1 INHBB27 inhibin, beta B - integrin, alpha 2 (CD49B, alpha 2 subunit 1 ITGA220 - of VLA-2 receptor) integrin, alpha 3 (antigen CD49C, alpha 3 1 ITGA320 - subunit of VLA-3 receptor) 1 ITGA620 integrin, alpha 6 - integrin, beta 1 (fibronectin receptor, beta 1 ITGB120 polypeptide, antigen CD29 includes - MDF2, MSK12) 1 ITGB420 integrin, beta 4 - 1 JUP20 junction plakoglobin - 1 KARS20 lysyl-tRNA synthetase Up-regulation potassium channel tetramerization domain 1 KCTD125 Down-regulation containing 12 1 KLK1122 kallikrein-related peptidase 11 Up-regulation 1 KLK222 kallikrein-related peptidase 2 - 1 KLK527 kallikrein-related peptidase 5 - 1 KLK627 kallikrein-related peptidase 6 - 1 KRT111 keratin 1 - 1 KRT102 keratin 10 Up-regulation 1 KRT82 Up-regulation 1 LAMC227 laminin, gamma 2 - 1 LCN125 lipocalin 1 Down-regulation 1 LCN227 lipocalin 2 - 1 LCP120 lymphocyte cytosolic protein 1 (L-plastin) - 1 LDHB2 lactate dehydrogenase B Down-regulation 1 LGALS12 lectin, galactoside-binding, soluble, 1 Down-regulation 1 LMAN123 lectin, mannose-binding, 1 Down-regulation 1 LMNB12 Up-regulation 1 LRG127 leucine-rich alpha-2-glycoprotein 1 - latent transforming growth factor beta 1 LTBP128 Up-regulation binding protein 1 latent transforming growth factor beta 1 LTBP227 - binding protein 2 1 LTBP328 latent transforming growth factor beta Up-regulation binding protein 3 1 MAN1A128 mannosidase, alpha, class 1A, member 1 Up-regulation 1 MAP2K22 mitogen-activated protein kinase kinase 2 Up-regulation myristoylated alanine-rich protein kinase C 1 MARCKS20 - substrate 1 MCCC22 methylcrotonoyl-CoA carboxylase 2 (beta) Up-regulation 1 MDK27 midkine (neurite growth-promoting factor 2 - mannosyl (alpha-1,6-)-glycoprotein 1 MGAT528 beta-1,6-N-acetyl-glucosaminyltransferase Up-regulation

1 MME21 membrane metallo-endopeptidase Down-regulation matrix metallopeptidase 1 (interstitial 1 MMP128 - collagenase) 1 MSN20 moesin - 1 MUC5B27 , oligomeric /gel-forming - 1 MYDGF27 myeloid-derived growth factor - 1 MYO1B20 myosin IB - 1 MYO1C20 myosin IC - 1 MYO1D20 myosin ID - 1 MYOF20 myoferlin - N-ethylmaleimide-sensitive factor 1 NAPA20 - attachment protein, alpha 1 NCKAP120 NCK-associated protein 1 - 1 NFE2L225 nuclear factor, erythroid 2-like 2 Down-regulation NME/NM23 nucleoside diphosphate 1 NME12 Up-regulation kinase 1 NME/NM23 nucleoside diphosphate 1 NME21 Up-regulation kinase 2 1 NPC227 Niemann-Pick disease, type C2 - 1 OXCT12 3-oxoacid CoA transferase 1 Up-regulation 1 PA2G425 proliferation-associated 2G4, 38kDa Up-regulation 1 PABPC125 poly(A) binding protein, cytoplasmic 1 Up-regulation 1 PARK721 parkinson protein 7 Down-regulation proprotein convertase subtilisin/ type 1 PCSK1N28 Up-regulation 1 inhibitor programmed cell death 6 interacting 1 PDCD6IP20 - protein protein disulfide isomerase family A, 1 PDIA41 Up-regulation member 4 protein disulfide isomerase family A, 1 PDIA623 Up-regulation member 6 prenyl (decaprenyl) diphosphate synthase, 1 PDSS224 - subunit 2 1 PFN120 1 - 1 PGAM129 phosphoglycerate mutase 1 Up-regulation 1 PGM35 phosphoglucomutase 3 Down-regulation progesterone receptor membrane 1 PGRMC128 Up-regulation component 1 1 PHB225 prohibitin 2 Up-regulation 1 PKM20 pyruvate kinase, muscle - 1 PLAG124 pleiomorphic adenoma gene 1 - 1 PLAU27 plasminogen activator, - 1 PLEC20 - 1 PLG27 plasminogen - 1 PLS320 plastin 3 - 1 PLTP27 phospholipid transfer protein - 1 PLXNB220 plexin B2 - 1 POSTN1 periostin, osteoblast specific factor Up-regulation 1 PPA22 pyrophosphatase (inorganic) 2 Up-regulation 1 PPIA20 peptidylprolyl isomerase A (cyclophilin A) - 1 PRDX223 peroxiredoxin 2 Down-regulation 1 PRDX325 peroxiredoxin 3 Up-regulation 1 PRDX629 peroxiredoxin 6 Up-regulation protein kinase, cAMP-dependent, 1 PRKACA25 Down-regulation catalytic, alpha protein kinase, cAMP-dependent, 1 PRKAR1A25 Down-regulation regulatory, type I, alpha 1 PRKCDBP1 protein kinase C, delta binding protein Down-regulation 1 PROS128 (alpha) Up-regulation 1 PSAP27 prosaposin - 1 PTGES325 prostaglandin E synthase 3 (cytosolic) Down-regulation 1 PTGR25 prostaglandin reductase 2 Down-regulation 1 PTMA23 prothymosin, alpha Up-regulation protein tyrosine phosphatase, receptor 1 PTPRS21 Down-regulation type, S 1 PTX327 pentraxin 3, long - 1 PYGB5 phosphorylase, glycogen; brain Down-regulation 1 RAB1020 RAB10, member RAS oncogene family - 1 RAB11A20 RAB10, member RAS oncogene family - 1 RAB1220 RAB11A, member RAS oncogene family - 1 RAB1320 RAB12, member RAS oncogene family - 1 RAB1420 RAB13, member RAS oncogene family - 1 RAB1A20 RAB14, member RAS oncogene family - 1 RAB1B20 RAB1A, member RAS oncogene family - 1 RAB22A20 RAB1B, member RAS oncogene family - 1 RAB27B20 RAB27B, member RAS oncogene family - 1 RAB3520 RAB35, member RAS oncogene family - 1 RAB5A20 RAB5A, member RAS oncogene family - 1 RAB5B20 RAB5B, member RAS oncogene family - 1 RAB7A20 RAB7A, member RAS oncogene family - 1 RAB8A20 RAB8A, member RAS oncogene family - 1 RAB8B20 RAB8B, member RAS oncogene family - 1 RDX20 radixin - 1 RNASET227 ribonuclease T2 - roundabout, axon guidance receptor, 1 ROBO128 Up-regulation homolog 1 (Drosophila) 1 RPL10A1 ribosomal protein L10a Up-regulation 1 RPL1425 ribosomal protein L14 Down-regulation 1 RPS624 ribosomal protein S6 - 1 RPSA25 ribosomal protein SA Up-regulation 1 S100A827 S100 calcium binding protein A8 - 1 S100A927 S100 calcium binding protein A9 - 1 SCRN15 secernin 1 Down-regulation succinate dehydrogenase complex, 1 SDHA2 Up-regulation subunit A, flavoprotein (Fp) 1 SDPR1 serum deprivation response Down-regulation 1 SEC132 SEC13 homolog (S. cerevisiae) Up-regulation sema domain, immunoglobulin domain 1 SEMA3F27 (Ig), short basic domain, secreted, - (semaphorin) 3F 1 SERBP125 SERPINE1 mRNA binding protein 1 Up-regulation 1 SMAD224 SMAD family member 2 - 1 SMAD424 SMAD family member 4 - 1

1 SORBS1 sorbin and SH3 domain containing 1 Down-regulation 1 SORD1 Up-regulation 1 SPINT127 serine peptidase inhibitor, Kunitz type 1 - 2

1 SRSF1 serine/arginine-rich splicing factor 1 Down-regulation 1 STC227 stanniocalcin 2 - 1 STOML22 stomatin (EPB72)-like 2 Up-regulation 1 STX420 4 - 1 STXBP320 syntaxin binding protein 3 - synaptotagmin binding, cytoplasmic RNA 1 SYNCRIP25 Up-regulation interacting protein 1 SYNJ225 synaptojanin 2 Down-regulation 1 SYNM5 , protein Up-regulation 1 TAGLN2 transgelin Down-regulation 1 TALDO123 transaldolase 1 Up-regulation 1 TCP15 t-complex 1 Up-regulation 1 TGM225 transglutaminase 2 Down-regulation 1 TGM421 transglutaminase 4 Down-regulation 1 THBS127 thrombospondin 1 - 1 TIMP227 TIMP metallopeptidase inhibitor 2 - 1 TINAGL127 tubulointerstitial nephritis antigen-like 1 - 1 TLR927 toll-like receptor 9 - 1 TPI129 triosephosphate isomerase 1 Up-regulation 1 TPM11 tropomyosin 1 (alpha) Down-regulation 4

1 TPM2 tropomyosin 2 (beta) Up-regulation 1 TPT127 tumor protein, translationally-controlled 1 - 1 TTC385 tetratricopeptide repeat domain 38 Down-regulation 1 TUBA1B20 tubulin, alpha 1b - 1 TUBB20 tubulin, beta class I - 1 TUBB4A20 tubulin, beta 4A class IVa - 1 TUBB4B4 tubulin, beta 4B class IVb Up-regulation twisted gastrulation BMP signaling 1 TWSG128 Up-regulation modulator 1 1 UBE2N2 ubiquitin-conjugating enzyme E2N Up-regulation ubiquitin carboxyl-terminal esterase L1 1 UCHL12 Down-regulation (ubiquitin thiolesterase) 1 VAMP820 vesicle-associated 8 - 1 VIM25 vimentin Up-regulation 1 YBX124 Y box binding protein 1 - tyrosine 3-monooxygenase/tryptophan 1 YWHAB20 - 5-monooxygenase activation protein, beta tyrosine 3-monooxygenase/tryptophan 1 YWHAE20 5-monooxygenase activation protein, - epsilon tyrosine 3-monooxygenase/tryptophan 1 YWHAG4 5-monooxygenase activation protein, Up-regulation gamma tyrosine 3-monooxygenase/tryptophan 1 YWHAQ20 - 5-monooxygenase activation protein, theta tyrosine 3-monooxygenase/tryptophan 1 YWHAZ20 - 5-monooxygenase activation protein, zeta 1 ZYX1 zyxin Down-regulation Notes: “1 Up, 2 Down” indicates this protein was once reported as up-regulated and twice reported as down-regulated. “-” indicates literature did not provide expression information. In this table, the frequency with which proteins are reported is not consistent with the frequency of expression because some studies did not provide expression information.

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