Polyclonal Antibody to SNAI2 / SLUG - Purified

OriGene Technologies, Inc. OriGene Technologies GmbH

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AP07738PU-N Polyclonal Antibody to SNAI2 / SLUG - Purified

Alternate names: Neural crest transcription factor Slug, Protein snail homolog 2, SLUGH, Zinc finger protein SNAI2 Quantity: 50 µg Concentration: 1 mg/ml Background: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. Uniprot ID: O43623 NCBI: NP_003059.1 GeneID: 6591 Host: Rabbit Immunogen: Synthetic 13 amino acid peptide from near the center of human SNAI2 / SLUG Format: State: Liquid Ig fraction Buffer System: PBS containing 0.02% Sodium azide as preservative Applications: Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 1 - 2 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: Detects SNAI2 / SLUG Species: Human and Mouse. Other species not tested. Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: 1. Cohen M.E., Yin M., Paznekas W.A., Schertzer M., Wood S., Jabs E.W.: Human SLUG gene organization, expression, and chromosome map location on 8q. Genomics 51: 468-471 (1998) 2. Stegmann K., Boecker J., Kosan C., Ermert A., Kunz J., Koch M.C.: Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region. Mutat. Res. 406: 63-69 (1999) 3. Gerhard D.S. et al. (The MGC Project Team): The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14:2121-2127 (2004)

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20170919 1 / 2 AP07738PU-N: Polyclonal Antibody to SNAI2 / SLUG - Purified

Pictures: Immunohistochemistry staining of human brain, cerebellum (Formalin- fixed, Paraffin-embedded tissue after heat-induced antigen retrieval) using SNAI2 / SLUG antibody Cat.-No. AP07738PU-N (antibody concentration 5 ug/ml).

Immunohistochemistry staining of human heart (Formalin-fixed, Paraffin- embedded tissue after heat-induced antigen retrieval) using SNAI2 / SLUG antibody Cat.-No. AP07738PU-N (antibody concentration 5 ug/ml).

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20170919 2 / 2