Minimally invasive microneedles for ocular drug delivery
Thakur, R., Tekko, I., McAvoy, K., Donnelly, R. F., McMillian, H., & Jones, D. (2017). Minimally invasive microneedles for ocular drug delivery. Expert Opinion on Drug Delivery, 14(4), 525-537. https://doi.org/10.1080/17425247.2016.1218460, https://doi.org/10.1080/17425247.2016.1218460
Published in: Expert Opinion on Drug Delivery
Document Version: Peer reviewed version
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Publisher rights Copyright 2016 Taylor and Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Drug Delivery on 3/08/2016, available online: http://www.tandfonline.com/10.1080/17425247.2016.1218460.
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Minimally invasive microneedles for ocular drug delivery
Journal: Expert Opinion on Drug Delivery
Manuscript ID EODD-2016-0127.R1
Manuscript Type: Review
Ocular drug delivery, Posterior segment, Anterior segment, Microneedle, Keywords: Minimally-invasive
URL: http://mc.manuscriptcentral.com/eodd Email:[email protected] Page 1 of 37 Expert Opinion on Drug Delivery
1 2 3 REVIEW 4 5 Minimally invasive microneedles for ocular drug delivery 6 7 8 Thakur Raghu Raj Singh*, Ismaiel Tekko, Kathryn McAvoy, Ryan F Donnelly, 9 10 Hannah McMillian, David Jones 11 12 School of Pharmacy, Queen’s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast 13 BT9 7BL, UK 14 For Peer Review Only 15 16 *Corresponding Author 17 18 School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn 19 20 Road, Belfast, BT9 7BL, United Kingdom 21 22 Tel: +44 (0) 28 9097 5814 23 24 25 Fax: +44 (0) 28 9024 7794 26 27 Email: [email protected] 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54
55 56 57 58 59 60 URL: http://mc.manuscriptcentral.com/eodd Email:[email protected] Expert Opinion on Drug Delivery Page 2 of 37
1 2 3 Abstract 4 5 Introduction: Anterior and posterior segment eye diseases are highly challenging to 6 7 treat, due to the barrier properties and relative inaccessibility of the ocular tissues. 8 9 Topical eye drops and systemically delivered treatments result in low bioavailability. 10 Alternatively, direct injection of medication into the ocular tissues is clinically 11 12 employed to overcome the barrier properties, but injections cause significant tissue 13 14 damageFor and are associated Peer with a Reviewnumber of untoward side Only effects and poor patient 15 compliance. Microneedles (MNs) has been recently introduced as a minimally 16 17 invasive means for localizing drug formulation within the target ocular tissues with 18 19 greater precision and accuracy than the hypodermic needles. 20 21 Areas covered: This review article seeks to provide an overview of a range of 22 23 challenges that are often faced to achieve efficient ocular drug levels within targeted 24 25 tissue(s) of the eye. It also describes the problems encountered using conventional 26 hypodermic needle