CURRICULUM VITAE
Lars Christian Pedersen
ADDRESS Bldg. 101, MD F3-09 111 TW Alexander Dr NIEHS/NIH RTP, NC 27709 Email: [email protected] Phone: 984-287-3538 (work) EDUCATION
1990 B.S., Chemistry, University of North Carolina, Chapel Hill, NC 1994 Ph.D., Biochemistry, University of Washington, Seattle, WA
EMPLOYMENT 1991-1992 Teaching Assistant, University of Washington, Seattle, WA 1994-1996 PostDoc, Institute for Enzyme Research, U. of Wisconsin-Madison, Madison, Wis. 1996-1997 IRTA Fellow, NIEHS (NIH), RTP, NC 1997-2001 Research Fellow, NIEHS (NIH), RTP, NC 2001-present Staff Scientist, Co-Director of Structural Biology Core, Head of Structure Function Group, NIEHS (NIH), RTP, NC
ADJUNCT APPOINTMENTS 2007-present Adjunct Associate Professor with the Division of Chemical Biology and Medicinal Chemistry, School of Pharmacy, University of North Carolina at Chapel Hill, NC
HONORS & AWARDS 1994/95 The University of Washington Graduate School's Dissertation Prize in Protein Science (for thesis entitled: X-ray Structure Determination of Factor XIII) 1997 National Institutes of Health Award of Merit 2006 National Institutes of Health Peer Award 2011 NIEHS Paper of the Year Award: “The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. J. Allergy Clin Immunol. 125:909-17 (2010).” 2018 National Institute of Health Award of Merit for implementation of CryoEM at NIEHS
INVITED PRESENTATIONS:
1998 Department of Biochemistry and Biophysics, University of North Carolina 1998 Department of Biochemistry Research Seminar, Oklahoma Medical Research Foundation 2001 Kobe Pharmaceutical University, Japan. 2001 Osaka University, Japan. 2001 Xth International Workshop on Glucuronidation and the UDP-Glucuronosyltransferases, Japan 2001 Department of Pharmacy, University of North Carolina 2002 Department of Biochemistry, St. Louis University 2005 Biochemistry Seminar Series, North Carolina State University 2005 Biophysics Form, University of North Carolina 2006 Department of Biochemistry, University of Washington 2007 Japanese Society of Carbohydrate Research, Fukuoka, Japan 2008 Nebraska Research and Innovation Conference, Lincoln, Nebraska 2011 EAL:Proteoglycans:Health, Disease and Therapeutics, Nancy, France 2011 Current Opinion Conference: Structural Biology and DNA Repair, Amsterdam, Netherlands 2013 American Chemical Society Meeting: CARB section, New Orleans 2013 University of North Carolina Career Blitz, University of North Carolina 2013 Division of Medicinal and Natural Products Chemistry, University of Iowa 2014 Proteoglycans Gordon Conference, Andover New Hampshire 2014 12th International Symposium on Cytochrome P450, Kyoto Japan 2014 Pharmacogenetics Seminar Series, NIEHS 2016 University of Cincinnati, Dept. of Molecular Genetics Seminar Series, Cincinnati, Ohio 2017 University of South Carolina, Dept. of Chemistry and Biochemistry, Columbia, South Carolina
Articles in peer-reviewed journals:
1. PEDERSEN LC, Yee VC, Bishop PD, Le Trong I, Teller DC, Stenkamp RE. Transglutaminase factor XIII uses proteinase-like catalytic triad to crosslink macromolecules. Protein science : a publication of the Protein Society. 1994;3(7):1131-5. Epub 1994/07/01. doi: 10.1002/pro.5560030720. PubMed PMID: 7920263; PMCID: PMC2142901. 2. PEDERSEN LC, Yee VC, von Dassow G, Hazeghazam M, Reeck GR, Stenkamp RE, Teller DC. The corn inhibitor of blood coagulation factor XIIa. Crystallization and preliminary crystallographic analysis. Journal of molecular biology. 1994;236(1):385-7. Epub 1994/02/11. doi: 10.1006/jmbi.1994.1147. PubMed PMID: 8107123. 3. Yee VC, PEDERSEN LC, Le Trong I, Bishop PD, Stenkamp RE, Teller DC. Three- dimensional structure of a transglutaminase: human blood coagulation factor XIII. Proceedings of the National Academy of Sciences of the United States of America. 1994;91(15):7296-300. Epub 1994/07/19. PubMed PMID: 7913750; PMCID: PMC44386. 4. PEDERSEN LC, Benning MM, Holden HM. Structural investigation of the antibiotic and ATP- binding sites in kanamycin nucleotidyltransferase. Biochemistry. 1995;34(41):13305-11. Epub 1995/10/17. PubMed PMID: 7577914. 5. Yee VC, PEDERSEN LC, Bishop PD, Stenkamp RE, Teller DC. Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII. Thrombosis research. 1995;78(5):389-97. Epub 1995/06/01. PubMed PMID: 7660355. 6. Kakuta Y, Pedersen LG, Carter CW, Negishi M, PEDERSEN LC. Crystal structure of estrogen sulphotransferase. Nature structural biology. 1997;4(11):904-8. Epub 1997/11/14. PubMed PMID: 9360604. 7. Behnke CA, Yee VC, Trong IL, PEDERSEN LC, Stenkamp RE, Kim SS, Reeck GR, Teller DC. Structural determinants of the bifunctional corn Hageman factor inhibitor: x-ray crystal structure at 1.95 A resolution. Biochemistry. 1998;37(44):15277-88. Epub 1998/11/04. doi: 10.1021/bi9812266. PubMed PMID: 9799488. 8. Kakuta Y, PEDERSEN LC, Chae K, Song WC, Leblanc D, London R, Carter CW, Negishi M. Mouse steroid sulfotransferases: substrate specificity and preliminary X-ray crystallographic analysis. Biochemical pharmacology. 1998;55(3):313-7. Epub 1998/03/04. PubMed PMID: 9484797. 9. Kakuta Y, Pedersen LG, PEDERSEN LC, Negishi M. Conserved structural motifs in the sulfotransferase family. Trends in biochemical sciences. 1998;23(4):129-30. Epub 1998/05/19. PubMed PMID: 9584614. 10. Kakuta Y, Petrotchenko EV, PEDERSEN LC, Negishi M. The sulfuryl transfer mechanism. Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis. The Journal of biological chemistry. 1998;273(42):27325-30. Epub 1998/10/09. PubMed PMID: 9765259. 11. Sueyoshi T, Kakuta Y, PEDERSEN LC, Wall FE, Pedersen LG, Negishi M. A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase. FEBS letters. 1998;433(3):211-4. Epub 1998/09/23. PubMed PMID: 9744796. 12. Bartolotti L, Kakuta Y, Pedersen L, Negishi M, Pedersen L. A quantum mechanical study of the transfer of biological sulfate. J Mol Struc-Theochem. 1999;461:105-11. doi: Doi 10.1016/S0166- 1280(98)00424-2. PubMed PMID: WOS:000079265300011. 13. Fox BA, Yee VC, PEDERSEN LC, Le Trong I, Bishop PD, Stenkamp RE, Teller DC. Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography. The Journal of biological chemistry. 1999;274(8):4917-23. Epub 1999/02/13. PubMed PMID: 9988734. 14. Kakuta Y, Sueyoshi T, Negishi M, PEDERSEN LC. Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1. The Journal of biological chemistry. 1999;274(16):10673-6. Epub 1999/04/10. PubMed PMID: 10196134. 15. Marsolais F, Laviolette M, Kakuta Y, Negishi M, PEDERSEN LC, Auger M, Varin L. 3'- Phosphoadenosine 5'-phosphosulfate binding site of flavonol 3-sulfotransferase studied by affinity chromatography and 31P NMR. Biochemistry. 1999;38(13):4066-71. Epub 1999/04/09. doi: 10.1021/bi982239m. PubMed PMID: 10194320. 16. Ong E, Yeh JC, Ding Y, Hindsgaul O, PEDERSEN LC, Negishi M, Fukuda M. Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis. The Journal of biological chemistry. 1999;274(36):25608-12. Epub 1999/08/28. PubMed PMID: 10464296. 17. Petrotchenko EV, Doerflein ME, Kakuta Y, PEDERSEN LC, Negishi M. Substrate gating confers steroid specificity to estrogen sulfotransferase. The Journal of biological chemistry. 1999;274(42):30019-22. Epub 1999/10/09. PubMed PMID: 10514486. 18. Gorokhov A, Perera L, Darden TA, Negishi M, PEDERSEN LC, Pedersen LG. Heparan sulfate biosynthesis: a theoretical study of the initial sulfation step by N-deacetylase/N- sulfotransferase. Biophysical journal. 2000;79(6):2909-17. Epub 2000/12/07. doi: 10.1016/s0006- 3495(00)76528-3. PubMed PMID: 11106599; PMCID: PMC1301170. 19. King RS, Sharma V, PEDERSEN LC, Kakuta Y, Negishi M, Duffel MW. Structure-function modeling of the interactions of N-alkyl-N-hydroxyanilines with rat hepatic aryl sulfotransferase IV. Chemical research in toxicology. 2000;13(12):1251-8. Epub 2000/12/22. PubMed PMID: 11123966. 20. PEDERSEN LC, Petrotchenko EV, Negishi M. Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. FEBS letters. 2000;475(1):61-4. Epub 2000/06/16. PubMed PMID: 10854859. 21. PEDERSEN LC, Tsuchida K, Kitagawa H, Sugahara K, Darden TA, Negishi M. Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I. The Journal of biological chemistry. 2000;275(44):34580-5. Epub 2000/08/18. doi: 10.1074/jbc.M007399200. PubMed PMID: 10946001. 22. Petrotchenko EV, PEDERSEN LC, Borchers CH, Tomer KB, Negishi M. The dimerization motif of cytosolic sulfotransferases. FEBS letters. 2001;490(1-2):39-43. Epub 2001/02/15. PubMed PMID: 11172807. 23. PEDERSEN LC, Darden TA, Negishi M. Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA. The Journal of biological chemistry. 2002;277(24):21869-73. Epub 2002/04/16. doi: 10.1074/jbc.M112343200. PubMed PMID: 11950836. 24. PEDERSEN LC, Petrotchenko E, Shevtsov S, Negishi M. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. The Journal of biological chemistry. 2002;277(20):17928-32. Epub 2002/03/09. doi: 10.1074/jbc.M111651200. PubMed PMID: 11884392. 25. Gorokhov A, Negishi M, Johnson EF, PEDERSEN LC, Perera L, Darden TA, Pedersen LG. Explicit water near the catalytic I helix Thr in the predicted solution structure of CYP2A4. Biophysical journal. 2003;84(1):57-68. Epub 2003/01/14. doi: 10.1016/s0006-3495(03)74832-2. PubMed PMID: 12524265; PMCID: PMC1302593. 26. Inoue K, Sobhany M, Transue TR, Oguma K, PEDERSEN LC, Negishi M. Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum. Microbiology (Reading, England). 2003;149(Pt 12):3361-70. Epub 2003/12/10. doi: 10.1099/mic.0.26586-0. PubMed PMID: 14663070. 27. Lee KA, Fuda H, Lee YC, Negishi M, Strott CA, PEDERSEN LC. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'- phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. The Journal of biological chemistry. 2003;278(45):44593- 9. Epub 2003/08/19. doi: 10.1074/jbc.M308312200. PubMed PMID: 12923182. 28. Mueller SO, Hall JM, Swope DL, PEDERSEN LC, Korach KS. Molecular determinants of the stereoselectivity of agonist activity of estrogen receptors (ER) alpha and beta. The Journal of biological chemistry. 2003;278(14):12255-62. Epub 2003/01/28. doi: 10.1074/jbc.M203578200. PubMed PMID: 12547836. 29. PEDERSEN LC, Dong J, Taniguchi F, Kitagawa H, Krahn JM, Pedersen LG, Sugahara K, Negishi M. Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis. The Journal of biological chemistry. 2003;278(16):14420-8. Epub 2003/02/04. doi: 10.1074/jbc.M210532200. PubMed PMID: 12562774. 30. Shevtsov S, Petrotchenko EV, PEDERSEN LC, Negishi M. Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. Environmental health perspectives. 2003;111(7):884-8. Epub 2003/06/05. PubMed PMID: 12782487; PMCID: PMC1241520. 31. Edavettal SC, Carrick K, Shah RR, PEDERSEN LC, Tropsha A, Pope RM, Liu J. A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate. Biochemistry. 2004;43(16):4680-8. Epub 2004/04/21. doi: 10.1021/bi0499112. PubMed PMID: 15096036. 32. Edavettal SC, Lee KA, Negishi M, Linhardt RJ, Liu J, PEDERSEN LC. Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. The Journal of biological chemistry. 2004;279(24):25789-97. Epub 2004/04/03. doi: 10.1074/jbc.M401089200. PubMed PMID: 15060080. 33. Garcia-Diaz M, Bebenek K, Krahn JM, Blanco L, Kunkel TA, PEDERSEN LC. A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Molecular cell. 2004;13(4):561-72. Epub 2004/03/03. PubMed PMID: 14992725. 34. Moon AF, Edavettal SC, Krahn JM, Munoz EM, Negishi M, Linhardt RJ, Liu J, PEDERSEN LC. Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. The Journal of biological chemistry. 2004;279(43):45185-93. Epub 2004/08/12. doi: 10.1074/jbc.M405013200. PubMed PMID: 15304505; PMCID: PMC4114238. 35. Batra VK, Beard WA, Shock DD, PEDERSEN LC, Wilson SH. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (London, England : 1993). 2005;13(8):1225-33. Epub 2005/08/09. doi: 10.1016/j.str.2005.05.010. PubMed PMID: 16084394. 36. Chen J, Avci FY, Munoz EM, McDowell LM, Chen M, PEDERSEN LC, Zhang L, Linhardt RJ, Liu J. Enzymatic redesigning of biologically active heparan sulfate. The Journal of biological chemistry. 2005;280(52):42817-25. Epub 2005/11/02. doi: 10.1074/jbc.M504338200. PubMed PMID: 16260789; PMCID: PMC4140617. 37. Garcia-Diaz M, Bebenek K, Gao G, PEDERSEN LC, London RE, Kunkel TA. Structure- function studies of DNA polymerase lambda. DNA repair. 2005;4(12):1358-67. Epub 2005/10/11. doi: 10.1016/j.dnarep.2005.09.001. PubMed PMID: 16213194. 38. Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, PEDERSEN LC. A closed conformation for the Pol lambda catalytic cycle. Nature structural & molecular biology. 2005;12(1):97-8. Epub 2004/12/21. doi: 10.1038/nsmb876. PubMed PMID: 15608652. 39. Ghosh M, Meiss G, Pingoud A, London RE, PEDERSEN LC. Structural insights into the mechanism of nuclease A, a betabeta alpha metal nuclease from Anabaena. The Journal of biological chemistry. 2005;280(30):27990-7. Epub 2005/05/18. doi: 10.1074/jbc.M501798200. PubMed PMID: 15897201. 40. Prasad R, Batra VK, Yang XP, Krahn JM, PEDERSEN LC, Beard WA, Wilson SH. Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. DNA repair. 2005;4(12):1347-57. Epub 2005/09/21. doi: 10.1016/j.dnarep.2005.08.009. PubMed PMID: 16172026. 41. Ueda A, Matsui K, Yamamoto Y, PEDERSEN LC, Sueyoshi T, Negishi M. Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR. The Biochemical journal. 2005;388(Pt 2):623-30. Epub 2004/12/22. doi: 10.1042/bj20041572. PubMed PMID: 15610065; PMCID: PMC1138970. 42. Batra VK, Beard WA, Shock DD, Krahn JM, PEDERSEN LC, Wilson SH. Magnesium- induced assembly of a complete DNA polymerase catalytic complex. Structure (London, England : 1993). 2006;14(4):757-66. Epub 2006/04/18. doi: 10.1016/j.str.2006.01.011. PubMed PMID: 16615916; PMCID: PMC1868394. 43. Batra VK, Shock DD, Prasad R, Beard WA, Hou EW, PEDERSEN LC, Sayer JM, Yagi H, Kumar S, Jerina DM, Wilson SH. Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(46):17231-6. Epub 2006/11/03. doi: 10.1073/pnas.0605069103. PubMed PMID: 17079493; PMCID: PMC1630674. 44. Garcia-Diaz M, Bebenek K, Krahn JM, PEDERSEN LC, Kunkel TA. Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Cell. 2006;124(2):331-42. Epub 2006/01/28. doi: 10.1016/j.cell.2005.10.039. PubMed PMID: 16439207. 45. Kirby TW, Harvey S, DeRose EF, Chalov S, Chikova AK, Perrino FW, Schaaper RM, London RE, PEDERSEN LC. Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex. The Journal of biological chemistry. 2006;281(50):38466-71. Epub 2006/09/16. doi: 10.1074/jbc.M606917200. PubMed PMID: 16973612; PMCID: PMC1876720. 46. Lin P, PEDERSEN LC, Batra VK, Beard WA, Wilson SH, Pedersen LG. Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(36):13294-9. Epub 2006/08/30. doi: 10.1073/pnas.0606006103. PubMed PMID: 16938895; PMCID: PMC1569157. 47. Picher AJ, Garcia-Diaz M, Bebenek K, PEDERSEN LC, Kunkel TA, Blanco L. Promiscuous mismatch extension by human DNA polymerase lambda. Nucleic acids research. 2006;34(11):3259- 66. Epub 2006/06/30. doi: 10.1093/nar/gkl377. PubMed PMID: 16807316; PMCID: PMC1904104. 48. Garcia-Diaz M, Bebenek K, Krahn JM, PEDERSEN LC, Kunkel TA. Role of the catalytic metal during polymerization by DNA polymerase lambda. DNA repair. 2007;6(9):1333-40. Epub 2007/05/04. doi: 10.1016/j.dnarep.2007.03.005. PubMed PMID: 17475573; PMCID: PMC1989765. 49. Ghosh M, Meiss G, Pingoud AM, London RE, PEDERSEN LC. The nuclease a-inhibitor complex is characterized by a novel metal ion bridge. The Journal of biological chemistry. 2007;282(8):5682-90. Epub 2006/12/02. doi: 10.1074/jbc.M605986200. PubMed PMID: 17138564; PMCID: PMC2072808. 50. McKenna CE, Kashemirov BA, Upton TG, Batra VK, Goodman MF, PEDERSEN LC, Beard WA, Wilson SH. (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society. 2007;129(50):15412-3. Epub 2007/11/23. doi: 10.1021/ja072127v. PubMed PMID: 18031037; PMCID: PMC2677377. 51. Moon AF, Garcia-Diaz M, Bebenek K, Davis BJ, Zhong X, Ramsden DA, Kunkel TA, PEDERSEN LC. Structural insight into the substrate specificity of DNA Polymerase mu. Nature structural & molecular biology. 2007;14(1):45-53. Epub 2006/12/13. doi: 10.1038/nsmb1180. PubMed PMID: 17159995. 52. Sucato CA, Upton TG, Kashemirov BA, Batra VK, Martinek V, Xiang Y, Beard WA, PEDERSEN LC, Wilson SH, McKenna CE, Florian J, Warshel A, Goodman MF. Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Biochemistry. 2007;46(2):461-71. Epub 2007/01/11. doi: 10.1021/bi061517b. PubMed PMID: 17209556. 53. Xu D, Song D, PEDERSEN LC, Liu J. Mutational study of heparan sulfate 2-O- sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. The Journal of biological chemistry. 2007;282(11):8356-67. Epub 2007/01/18. doi: 10.1074/jbc.M608062200. PubMed PMID: 17227754. 54. Batra VK, Beard WA, Shock DD, PEDERSEN LC, Wilson SH. Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell. 2008;30(3):315-24. Epub 2008/05/13. doi: 10.1016/j.molcel.2008.02.025. PubMed PMID: 18471977; PMCID: PMC2399898. 55. Bebenek K, Garcia-Diaz M, Foley MC, PEDERSEN LC, Schlick T, Kunkel TA. Substrate- induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. EMBO reports. 2008;9(5):459-64. Epub 2008/03/29. doi: 10.1038/embor.2008.33. PubMed PMID: 18369368; PMCID: PMC2278112. 56. Bethea HN, Xu D, Liu J, PEDERSEN LC. Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(48):18724-9. Epub 2008/11/22. doi: 10.1073/pnas.0806975105. PubMed PMID: 19022906; PMCID: PMC2596202. 57. Lin P, Batra VK, PEDERSEN LC, Beard WA, Wilson SH, Pedersen LG. Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(15):5670-4. Epub 2008/04/09. doi: 10.1073/pnas.0801257105. PubMed PMID: 18391201; PMCID: PMC2311328. 58. Mueller GA, Moon AF, Derose EF, Havener JM, Ramsden DA, PEDERSEN LC, London RE. A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda. DNA repair. 2008;7(8):1340-51. Epub 2008/07/01. doi: 10.1016/j.dnarep.2008.04.018. PubMed PMID: 18585102; PMCID: PMC2583787. 59. Tone Y, PEDERSEN LC, Yamamoto T, Izumikawa T, Kitagawa H, Nishihara J, Tamura J, Negishi M, Sugahara K. 2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. The Journal of biological chemistry. 2008;283(24):16801-7. Epub 2008/04/11. doi: 10.1074/jbc.M709556200. PubMed PMID: 18400750; PMCID: PMC2423269. 60. Ullah H, Scappini EL, Moon AF, Williams LV, Armstrong DL, PEDERSEN LC. Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana. Protein science : a publication of the Protein Society. 2008;17(10):1771-80. Epub 2008/08/22. doi: 10.1110/ps.035121.108. PubMed PMID: 18715992; PMCID: PMC2548356. 61. Xu D, Moon AF, Song D, PEDERSEN LC, Liu J. Engineering sulfotransferases to modify heparan sulfate. Nature chemical biology. 2008;4(3):200-2. Epub 2008/01/29. doi: 10.1038/nchembio.66. PubMed PMID: 18223645; PMCID: PMC2676843. 62. Zhong X, PEDERSEN LC, Kunkel TA. Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity. Nucleic acids research. 2008;36(12):3892-904. Epub 2008/05/27. doi: 10.1093/nar/gkn312. PubMed PMID: 18503083; PMCID: PMC2475618. 63. Beard WA, Shock DD, Batra VK, PEDERSEN LC, Wilson SH. DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". The Journal of biological chemistry. 2009;284(46):31680-9. Epub 2009/09/18. doi: 10.1074/jbc.M109.029843. PubMed PMID: 19759017; PMCID: PMC2797239. 64. Cisneros GA, Perera L, Schaaper RM, PEDERSEN LC, London RE, Pedersen LG, Darden TA. Reaction mechanism of the epsilon subunit of E. coli DNA polymerase III: insights into active site metal coordination and catalytically significant residues. Journal of the American Chemical Society. 2009;131(4):1550-6. Epub 2009/01/06. doi: 10.1021/ja8082818. PubMed PMID: 19119875; PMCID: PMC2652123. 65. Garcia-Diaz M, Bebenek K, Larrea AA, Havener JM, Perera L, Krahn JM, PEDERSEN LC, Ramsden DA, Kunkel TA. Template strand scrunching during DNA gap repair synthesis by human polymerase lambda. Nature structural & molecular biology. 2009;16(9):967-72. Epub 2009/08/25. doi: 10.1038/nsmb.1654. PubMed PMID: 19701199; PMCID: PMC2767187. 66. Upton TG, Kashemirov BA, McKenna CE, Goodman MF, Prakash GK, Kultyshev R, Batra VK, Shock DD, PEDERSEN LC, Beard WA, Wilson SH. Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic letters. 2009;11(9):1883-6. Epub 2009/04/09. doi: 10.1021/ol701755k. PubMed PMID: 19351147; PMCID: PMC2722935. 67. Arana ME, Holmes SF, Fortune JM, Moon AF, PEDERSEN LC, Kunkel TA. Functional residues on the surface of the N-terminal domain of yeast Pms1. DNA repair. 2010;9(4):448-57. Epub 2010/02/09. doi: 10.1016/j.dnarep.2010.01.010. PubMed PMID: 20138591; PMCID: PMC2856611. 68. Batra VK, Beard WA, Hou EW, PEDERSEN LC, Prasad R, Wilson SH. Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nature structural & molecular biology. 2010;17(7):889-90. Epub 2010/06/08. doi: 10.1038/nsmb.1852. PubMed PMID: 20526335; PMCID: PMC2921931. 69. Batra VK, PEDERSEN LC, Beard WA, Wilson SH, Kashemirov BA, Upton TG, Goodman MF, McKenna CE. Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. Journal of the American Chemical Society. 2010;132(22):7617-25. Epub 2010/05/15. doi: 10.1021/ja909370k. PubMed PMID: 20465217; PMCID: PMC2891752. 70. Mueller GA, Edwards LL, Aloor JJ, Fessler MB, Glesner J, Pomes A, Chapman MD, London RE, PEDERSEN LC. The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. The Journal of allergy and clinical immunology. 2010;125(4):909-17.e4. Epub 2010/03/17. doi: 10.1016/j.jaci.2009.12.016. PubMed PMID: 20226507; PMCID: PMC2885876. 71. Mueller GA, Gosavi RA, Krahn JM, Edwards LL, Cuneo MJ, Glesner J, Pomes A, Chapman MD, London RE, PEDERSEN LC. Der p 5 crystal structure provides insight into the group 5 dust mite allergens. The Journal of biological chemistry. 2010;285(33):25394-401. Epub 2010/06/11. doi: 10.1074/jbc.M110.128306. PubMed PMID: 20534590; PMCID: PMC2919102. 72. Surya Prakash GK, Zibinsky M, Upton TG, Kashemirov BA, McKenna CE, Oertell K, Goodman MF, Batra VK, PEDERSEN LC, Beard WA, Shock DD, Wilson SH, Olah GA. Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis- (difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(36):15693-8. Epub 2010/08/21. doi: 10.1073/pnas.1007430107. PubMed PMID: 20724659; PMCID: PMC2936638. 73. Bebenek K, PEDERSEN LC, Kunkel TA. Replication infidelity via a mismatch with Watson- Crick geometry. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(5):1862-7. Epub 2011/01/15. doi: 10.1073/pnas.1012825108. PubMed PMID: 21233421; PMCID: PMC3033279. 74. Moon AF, Midon M, Meiss G, Pingoud A, London RE, PEDERSEN LC. Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae. Nucleic acids research. 2011;39(7):2943-53. Epub 2010/11/30. doi: 10.1093/nar/gkq1152. PubMed PMID: 21113026; PMCID: PMC3074123. 75. Mueller GA, Gosavi RA, Pomes A, Wunschmann S, Moon AF, London RE, PEDERSEN LC. Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity. Allergy. 2011;66(7):878-85. Epub 2011/01/25. doi: 10.1111/j.1398- 9995.2010.02532.x. PubMed PMID: 21255036; PMCID: PMC3107396. 76. Schorzman AN, Perera L, Cutalo-Patterson JM, PEDERSEN LC, Pedersen LG, Kunkel TA, Tomer KB. Modeling of the DNA-binding site of yeast Pms1 by mass spectrometry. DNA repair. 2011;10(5):454-65. Epub 2011/03/01. doi: 10.1016/j.dnarep.2011.01.010. PubMed PMID: 21354867; PMCID: PMC3084373. 77. Gosavi RA, Moon AF, Kunkel TA, PEDERSEN LC, Bebenek K. The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda. Nucleic acids research. 2012;40(15):7518- 27. Epub 2012/05/16. doi: 10.1093/nar/gks413. PubMed PMID: 22584622; PMCID: PMC3424563. 78. Moon AF, Xu Y, Woody SM, Krahn JM, Linhardt RJ, Liu J, PEDERSEN LC. Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(14):5265-70. Epub 2012/03/21. doi: 10.1073/pnas.1117923109. PubMed PMID: 22431632; PMCID: PMC3325653. 79. Batra VK, Perera L, Lin P, Shock DD, Beard WA, PEDERSEN LC, Pedersen LG, Wilson SH. Amino acid substitution in the active site of DNA polymerase beta explains the energy barrier of the nucleotidyl transfer reaction. Journal of the American Chemical Society. 2013;135(21):8078-88. Epub 2013/05/08. doi: 10.1021/ja403842j. PubMed PMID: 23647366; PMCID: PMC3918438. 80. Clausen AR, Murray MS, Passer AR, PEDERSEN LC, Kunkel TA. Structure-function analysis of ribonucleotide bypass by B family DNA replicases. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(42):16802-7. Epub 2013/10/02. doi: 10.1073/pnas.1309119110. PubMed PMID: 24082122; PMCID: PMC3801065. 81. Gosavi RA, Knudsen GA, Birnbaum LS, PEDERSEN LC. Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis. Environmental health perspectives. 2013;121(10):1194-9. Epub 2013/08/21. doi: 10.1289/ehp.1306902. PubMed PMID: 23959441; PMCID: PMC3801471. 82. Mueller GA, PEDERSEN LC, Lih FB, Glesner J, Moon AF, Chapman MD, Tomer KB, London RE, Pomes A. The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment. The Journal of allergy and clinical immunology. 2013;132(6):1420-6. Epub 2013/08/07. doi: 10.1016/j.jaci.2013.06.014. PubMed PMID: 23915714; PMCID: PMC3844097. 83. Peterson EJ, Kireev D, Moon AF, Midon M, Janzen WP, Pingoud A, PEDERSEN LC, Singleton SF. Inhibitors of Streptococcus pneumoniae surface endonuclease EndA discovered by high-throughput screening using a PicoGreen fluorescence assay. Journal of biomolecular screening. 2013;18(3):247-57. Epub 2012/09/28. doi: 10.1177/1087057112461153. PubMed PMID: 23015019; PMCID: PMC4773034. 84. Winuthayanon W, Piyachaturawat P, Suksamrarn A, Burns KA, Arao Y, Hewitt SC, PEDERSEN LC, Korach KS. The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor alpha. Environmental health perspectives. 2013;121(4):433-9. Epub 2013/04/05. doi: 10.1289/ehp.1206122. PubMed PMID: 23552522; PMCID: PMC3620745. 85. Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, PEDERSEN LC, Esko JD. Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS chemical biology. 2013;8(7):1611-20. Epub 2013/05/18. doi: 10.1021/cb4001553. PubMed PMID: 23679870; PMCID: PMC3806902. 86. Hewitt SC, Li L, Grimm SA, Winuthayanon W, Hamilton KJ, Pockette B, Rubel CA, PEDERSEN LC, Fargo D, Lanz RB, DeMayo FJ, Schutz G, Korach KS. Novel DNA motif binding activity observed in vivo with an estrogen receptor alpha mutant mouse. Molecular endocrinology (Baltimore, Md). 2014;28(6):899-911. Epub 2014/04/10. doi: 10.1210/me.2014-1051. PubMed PMID: 24713037; PMCID: PMC4042070. 87. Liu C, Sheng J, Krahn JM, Perera L, Xu Y, Hsieh PH, Dou W, Liu J, PEDERSEN LC. Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase. The Journal of biological chemistry. 2014;289(19):13407-18. Epub 2014/03/22. doi: 10.1074/jbc.M113.530535. PubMed PMID: 24652287; PMCID: PMC4036349. 88. Moon AF, Gaudu P, PEDERSEN LC. Structural characterization of the virulence factor nuclease A from Streptococcus agalactiae. Acta crystallographica Section D, Biological crystallography. 2014;70(Pt 11):2937-49. Epub 2014/11/06. doi: 10.1107/s1399004714019725. PubMed PMID: 25372684; PMCID: PMC4220975. 89. Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, PEDERSEN LC. Sustained active site rigidity during synthesis by human DNA polymerase mu. Nature structural & molecular biology. 2014;21(3):253-60. Epub 2014/02/04. doi: 10.1038/nsmb.2766. PubMed PMID: 24487959; PMCID: PMC4164209. 90. Mueller GA, Ankney JA, Glesner J, Khurana T, Edwards LL, PEDERSEN LC, Perera L, Slater JE, Pomes A, London RE. Characterization of an anti-Bla g 1 scFv: epitope mapping and cross-reactivity. Molecular immunology. 2014;59(2):200-7. Epub 2014/03/29. doi: 10.1016/j.molimm.2014.02.003. PubMed PMID: 24667070; PMCID: PMC4097036. 91. PEDERSEN LC, Birnbaum LS, Gosavi RA, Knudsen GA. Crystallographic analysis and mimicking of estradiol binding: Pedersen et al. Respond. Environmental health perspectives. 2014;122(4):A91-2. Epub 2014/04/03. doi: 10.1289/ehp.1307987R. PubMed PMID: 24691124; PMCID: PMC3984220. 92. Zheng X, PEDERSEN LC, Gabel SA, Mueller GA, Cuneo MJ, DeRose EF, Krahn JM, London RE. Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation. Nucleic acids research. 2014;42(8):5361-77. Epub 2014/02/28. doi: 10.1093/nar/gku143. PubMed PMID: 24574528; PMCID: PMC4005681. 93. Dou W, Xu Y, Pagadala V, PEDERSEN LC, Liu J. Role of Deacetylase Activity of N- Deacetylase/N-Sulfotransferase 1 in Forming N-Sulfated Domain in Heparan Sulfate. The Journal of biological chemistry. 2015;290(33):20427-37. Epub 2015/06/26. doi: 10.1074/jbc.M115.664409. PubMed PMID: 26109066; PMCID: PMC4536448. 94. French JE, Gatti DM, Morgan DL, Kissling GE, Shockley KR, Knudsen GA, Shepard KG, Price HC, King D, Witt KL, PEDERSEN LC, Munger SC, Svenson KL, Churchill GA. Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity. Environmental health perspectives. 2015;123(3):237-45. Epub 2014/11/07. doi: 10.1289/ehp.1408202. PubMed PMID: 25376053; PMCID: PMC4348743. 95. Kirby TW, Gassman NR, Smith CE, PEDERSEN LC, Gabel SA, Sobhany M, Wilson SH, London RE. Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS. Scientific reports. 2015;5:13405. Epub 2015/08/26. doi: 10.1038/srep13405. PubMed PMID: 26304019; PMCID: PMC4548243. 96. Moon AF, Gosavi RA, Kunkel TA, PEDERSEN LC, Bebenek K. Creative template-dependent synthesis by human polymerase mu. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(33):E4530-6. Epub 2015/08/05. doi: 10.1073/pnas.1505798112. PubMed PMID: 26240373; PMCID: PMC4547271. 97. Mueller GA, PEDERSEN LC, Glesner J, Edwards LL, Zakzuk J, London RE, Arruda LK, Chapman MD, Caraballo L, Pomes A. Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis. The Journal of allergy and clinical immunology. 2015;136(5):1369-77. Epub 2015/05/02. doi: 10.1016/j.jaci.2015.03.015. PubMed PMID: 25930195; PMCID: PMC4624055. 98. Batra VK, Beard WA, PEDERSEN LC, Wilson SH. Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure (London, England : 1993). 2016;24(11):1863-75. Epub 2016/11/03. doi: 10.1016/j.str.2016.08.006. PubMed PMID: 27642161; PMCID: PMC5093059. 99. Moon AF, Krahn JM, Lu X, Cuneo MJ, PEDERSEN LC. Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic acids research. 2016;44(8):3946-57. Epub 2016/03/13. doi: 10.1093/nar/gkw143. PubMed PMID: 26969731; PMCID: PMC4856990. 100. Mueller GA, Randall TA, Glesner J, PEDERSEN LC, Perera L, Edwards LL, DeRose EF, Chapman MD, London RE, Pomes A. Serological, genomic and structural analyses of the major mite allergen Der p 23. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2016;46(2):365-76. Epub 2015/11/26. doi: 10.1111/cea.12680. PubMed PMID: 26602749; PMCID: PMC4732897. 101. Pham P, Afif SA, Shimoda M, Maeda K, Sakaguchi N, PEDERSEN LC, Goodman MF. Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification. DNA repair. 2016;43:48-56. Epub 2016/06/04. doi: 10.1016/j.dnarep.2016.05.029. PubMed PMID: 27258794; PMCID: PMC4917410. 102. Zheng X, PEDERSEN LC, Gabel SA, Mueller GA, DeRose EF, London RE. Unfolding the HIV-1 reverse transcriptase RNase H domain--how to lose a molecular tug-of-war. Nucleic acids research. 2016;44(4):1776-88. Epub 2016/01/17. doi: 10.1093/nar/gkv1538. PubMed PMID: 26773054; PMCID: PMC4770237. 103. Gabel SA, Duff MR, PEDERSEN LC, DeRose EF, Krahn JM, Howell EE, London RE. A structural basis for biguanide activity. Biochemistry. 2017. doi: 10.1021/acs.biochem.7b00619. PubMed PMID: 28766937. 104. Jamsen JA, Beard WA, PEDERSEN LC, Shock DD, Moon AF, Krahn JM, Bebenek K, Kunkel TA, Wilson SH. Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun. 2017;8(1):253. doi: 10.1038/s41467-017-00271-7. PubMed PMID: 28811466; PMCID: PMC5557891. 105. Xu Y, Moon AF, Xu S, Krahn JM, Liu J, PEDERSEN LC. Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases. ACS chemical biology. 2017;12(1):73-82. Epub 2017/01/21. doi: 10.1021/acschembio.6b00841. PubMed PMID: 28103688; PMCID: PMC5331487. 106. Kim K, PEDERSEN LC, Kirby TW, DeRose EF, London RE. Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications. Nucleic acids research. 2017;45(21):12374-87. doi: 10.1093/nar/gkx941. PubMed PMID: 29059378; PMCID: PMC5716189. 107. Moon AF, Pryor JM, Ramsden DA, Kunkel TA, Bebenek K, PEDERSEN LC. Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic acids research. 2017;45(15):9138-48. doi: 10.1093/nar/gkx527. PubMed PMID: 28911097; PMCID: PMC5587726. 108. Shizu R, Min J, Sobhany M, PEDERSEN LC, Mutoh S, Negishi M. Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation. The Journal of biological chemistry. 2018;293(1):333-44. doi: 10.1074/jbc.M117.806604. PubMed PMID: 29133527; PMCID: PMC5766923. 109. Min J, Perera L, Krahn JM, Jewell CM, Moon AF, Cidlowski JA, PEDERSEN LC. Probing Dominant Negative Behavior of Glucocorticoid Receptor beta through a Hybrid Structural and Biochemical Approach. Mol Cell Biol. 2018. doi: 10.1128/MCB.00453-17. PubMed PMID: 29437838; PMCID: PMC5879464. 110. Kirby TW, PEDERSEN LC, Gabel SA, Gassman NR, London RE. Variations in nuclear localization strategies among pol X family enzymes. Traffic. 2018. doi: 10.1111/tra.12600. PubMed PMID: 29931796. 111. Kaminski AM, Tumbale PP, Schellenberg MJ, Williams RS, Williams JG, Kunkel TA, PEDERSEN LC, Bebenek K. Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis. Nat Commun. 2018;9(1):2642. doi: 10.1038/s41467- 018-05024-8. PubMed PMID: 29980672; PMCID: PMC6035275. 112. PEDERSEN LC, Inoue K, Kim S, Perera L, Shaw ND. A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1. Commun Biol. 2019;2:255. doi: 10.1038/s42003-019-0499-y. PMID: 31312724 PMCID: PMC6620310. 113. Kaminski AM, Chiruvella KK, Ramsden DA, Kunkel TA, Bebenek K, PEDERSEN LC. Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res. 2019 Sep 26;47(17):9410-9422. doi: 10.1093/nar/gkz680. PMID: 31435651. 114. Kim K, Min J, Kirby TW, Gabel SA, PEDERSEN LC, London RE. Ligand binding characteristics of the Ku80 von Willebrand domain. DNA Repair (Amst). 2019 Oct 24;85:102739. doi: 10.1016/j.dnarep.2019.102739. PMID: 31733588.
Reviews or Letters:
1. Yee VC, Le Trong I, Bishop PD, PEDERSEN LC, Stenkamp RE, Teller DC. Structure and function studies of factor XIIIa by x-ray crystallography. Seminars in thrombosis and hemostasis. 1996;22(5):377-84. Epub 1996/01/01. doi: 10.1055/s-2007-999035. PubMed PMID: 8989820. 2. Negishi M, Pedersen LG, Petrotchenko E, Shevtsov S, Gorokhov A, Kakuta Y, PEDERSEN LC. Structure and function of sulfotransferases. Archives of biochemistry and biophysics. 2001;390(2):149-57. Epub 2001/06/09. doi: 10.1006/abbi.2001.2368. PubMed PMID: 11396917. 3. PEDERSEN LC, Darden TA, Kakuta Y, Negishi M. Crystal structure-based analysis of human glucuronyltransferase 1. Trends Glycosci Glyc. 2001;13(70):121-9. PubMed PMID: WOS:000169187500002. 4. Yoshimitsu K, PEDERSEN LC, Masahiko N. [Structural biology of heparan sulfate sulfotransferase]. Tanpakushitsu kakusan koso Protein, nucleic acid, enzyme. 2001;46(9):1254-60. Epub 2001/08/07. PubMed PMID: 11486371. 5. Yoshinari K, Petrotchenko EV, PEDERSEN LC, Negishi M. Crystal structure-based studies of cytosolic sulfotransferase. Journal of biochemical and molecular toxicology. 2001;15(2):67-75. Epub 2001/04/03. PubMed PMID: 11284047. 6. PEDERSEN LC, Negishi, M. Sulfotransferases. Wiley Encyclopedia of Molecular Medicine. 2002;5:3056-7. 7. Kakuta Y, Li L, PEDERSEN LC, Pedersen LG, Negishi M. Heparan sulphate N- sulphotransferase activity: reaction mechanism and substrate recognition. Biochemical Society transactions. 2003;31(2):331-4. Epub 2003/03/26. doi: 10.1042/. PubMed PMID: 12653630. 8. Negishi M, Dong J, Darden TA, Pedersen LG, PEDERSEN LC. Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2. Biochemical and biophysical research communications. 2003;303(2):393-8. Epub 2003/03/28. PubMed PMID: 12659829. 9. Verdugo DE, PEDERSEN, LC, Bertozzi, C.R. Small Molecule Inhibitors of the Sulfotransferases, in Carbohy. In: Wong C-H, editor. Carbohydrate-Based Drug Discovery: Wiley- VCH Verlag GmbH & Co. KGaA; 2003. p. 781-97. 10. Liu J, PEDERSEN LC. Anticoagulant heparan sulfate: structural specificity and biosynthesis. Applied microbiology and biotechnology. 2007;74(2):263-72. Epub 2006/11/30. doi: 10.1007/s00253-006-0722-x. PubMed PMID: 17131147; PMCID: PMC1876722. 11. Moon AF, Garcia-Diaz M, Batra VK, Beard WA, Bebenek K, Kunkel TA, Wilson SH, PEDERSEN LC. The X family portrait: structural insights into biological functions of X family polymerases. DNA repair. 2007;6(12):1709-25. Epub 2007/07/17. doi: 10.1016/j.dnarep.2007.05.009. PubMed PMID: 17631059; PMCID: PMC2128704. 12. Moon AF, Mueller GA, Zhong X, PEDERSEN LC. A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction. Protein science : a publication of the Protein Society. 2010;19(5):901-13. Epub 2010/03/03. doi: 10.1002/pro.368. PubMed PMID: 20196072; PMCID: PMC2868234. 13. Liu J, Moon AF, Sheng J, PEDERSEN LC. Understanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approach. Current opinion in structural biology. 2012;22(5):550-7. Epub 2012/07/31. doi: 10.1016/j.sbi.2012.07.004. PubMed PMID: 22840348; PMCID: PMC3711681. 14. Bebenek K, PEDERSEN LC, Kunkel TA. Structure-function studies of DNA polymerase lambda. Biochemistry. 2014;53(17):2781-92. Epub 2014/04/11. doi: 10.1021/bi4017236. PubMed PMID: 24716527; PMCID: PMC4018081. 15. Mueller GA, Maleki SJ, PEDERSEN LC. The molecular basis of peanut allergy. Current allergy and asthma reports. 2014;14(5):429. Epub 2014/03/19. doi: 10.1007/s11882-014-0429-5. PubMed PMID: 24633613; PMCID: PMC4785306. 16. Pomes A, Chruszcz M, Gustchina A, Minor W, Mueller GA, PEDERSEN LC, Wlodawer A, Chapman MD. 100 Years later: Celebrating the contributions of x-ray crystallography to allergy and clinical immunology. The Journal of allergy and clinical immunology. 2015;136(1):29-37.e10. Epub 2015/07/07. doi: 10.1016/j.jaci.2015.05.016. PubMed PMID: 26145985; PMCID: PMC4502579. 17. Pham P, Afif SA, Shimoda M, Maeda K, Sakaguchi N, PEDERSEN LC, Goodman MF. Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members. DNA repair. 2017;54:8-12. Epub 2017/04/08. doi: 10.1016/j.dnarep.2017.03.007. PubMed PMID: 28388461. 18. Mueller GA, Min J, Foo ACY, Pomés A, PEDERSEN LC. Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions. Curr Allergy Asthma Rep. 2019 Feb 28;19(3):17. doi: 10.1007/s11882-019-0848-4. PMID: 30815753.