Table of Contents (PDF)

Clinical Cancer Research Table of Contents

August 1, 2018 Volume 24 Number 15 SPECIAL FEATURES Perspectives

Highlights of This Issue 3475 3500 Report from the SWOG Radiation Oncology Committee: Research Objectives Workshop CCR Translations 2017 Paul Okunieff, Katherine Casey-Sawicki, Natalie A. Lockney, Bradford S. Hoppe, Heiko Enderling, 3477 The Need for Neddylation: A Key to Achieving Chelsea Pinnix, James Welsh, Sunil Krishnan, NED in Uveal Melanoma Greg Yothers, Martin Brown, Susan Knox, Robert Bristow, Jessica Yang, Omid Hamid, and Richard D. Carvajal Paul Spellman, Timur Mitin, Nima Nabavizadeh, See related article, p. 3741 Jerry Jaboin, H. Charles Manning, Felix Feng, Susan Galbraith, Abhishek A. Solanki, 3480 Tamoxifen Resistance Trumped and Oral Selective Matthew M. Harkenrider, Richard Tuli, Roy H. Decker, Estrogen Receptor Degraders Arrive Steven E. Finkelstein, Charles C. Hsu, Chul S. Ha, V. Craig Jordan Reshma Jagsi, Dean Shumway, Megan Daly, See related articles, p. 3681 and p. 3510 Tony J.C. Wang, Thomas J. Fitzgerald, Fran Laurie, David T. Marshall, David Raben, Louis Constine, þ 3483 Neratinib: Inching Up on the Cure Rate of HER2 Charles R. Thomas Jr, and Lisa A. Kachnic Breast Cancer? Nisha Unni, Dhivya R. Sudhan, and Carlos L. Arteaga See related article, p. 3486 CLINICAL TRIALS: TARGETED THERAPY

3510 A First-in-Human Study of the New Oral CCR Drug Updates Selective Estrogen Receptor Degrader AZD9496 for þ ER /HER2 Advanced Breast Cancer 3486 U.S. Food and Drug Administration Approval: Erika P. Hamilton, Manish R. Patel, Anne C. Armstrong, Neratinib for the Extended Adjuvant Treatment Richard D. Baird, Komal Jhaveri, Matthias Hoch, of Early-Stage HER2-Positive Breast Cancer Teresa Klinowska, Justin P.O. Lindemann, Harpreet Singh, Amanda J. Walker, Laleh Amiri-Kordestani, Shethah R. Morgan, Gaia Schiavon, Hazel M. Weir, and Joyce Cheng, Shenghui Tang, Pamela Balcazar, Seock-Ah Im See related commentary, p. 3480 Kimberly Barnett-Ringgold, Todd R. Palmby, Xianhua Cao, Nan Zheng, Qi Liu, Jingyu Yu, William F. Pierce, Selena R. Daniels, Rajeshwari Sridhara, Amna Ibrahim, Paul G. Kluetz, Gideon M. Blumenthal, Julia A. Beaver, and CLINICAL TRIALS: IMMUNOTHERAPY Richard Pazdur See related commentary, p. 3483 3519 A Multi-center Phase I Trial of Ipilimumab in Patients with Myelodysplastic Syndromes following Hypomethylating Agent Failure Review Amer M. Zeidan, Hanna A. Knaus, Tara M. Robinson, Andrea M.H. Towlerton, Edus H. Warren, Joshua F. Zeidner, 3492 Data Analysis Strategies in Medical Imaging Amanda L. Blackford, Amy S. Duffield, David Rizzieri, Chintan Parmar, Joseph D. Barry, Ahmed Hosny, Mark G. Frattini, Yair M. Levy, Mark A. Schroeder, John Quackenbush, and Hugo J.W.L. Aerts Anna Ferguson, Katherine E. Sheldon, Amy E. DeZern, Ivana Gojo, Steven D. Gore, Howard Streicher, Leo Luznik, and B. Douglas Smith

PRECISION MEDICINE AND IMAGING 3593 Clinicopathological Risk Factors for an Invasive Breast Cancer Recurrence after Ductal Carcinoma In Situ— – 3528 The Landscape of Actionable Genomic A Nested Case Control Study Alterations in Cell-Free Circulating Tumor DNA Lindy L. Visser, Lotte E. Elshof, Michael Schaapveld, from 21,807 Advanced Cancer Patients Koen van de Vijver, Emma J. Groen, Oliver A. Zill, Kimberly C. Banks, Stephen R. Fairclough, Mathilde M. Almekinders, Carolien Bierman, Stefanie A. Mortimer, James V. Vowles, Reza Mokhtari, Flora E. van Leeuwen, Emiel J. Rutgers, David R. Gandara, Philip C. Mack, Justin I. Odegaard, Marjanka K. Schmidt, Esther H. Lips, and Jelle Wesseling Rebecca J. Nagy, Arthur M. Baca, Helmy Eltoukhy, Darya I. Chudova, Richard B. Lanman, and 3602 Paclitaxel Plasma Concentration after the First AmirAli Talasaz Infusion Predicts Treatment-Limiting Peripheral Neuropathy 3539 Validation of a Plasma-Based Comprehensive Daniel L. Hertz, Kelley M. Kidwell, Kiran Vangipuram, Cancer Genotyping Assay Utilizing Orthogonal Feng Li, Manjunath P. Pai, Monika Burness, Tissue- and Plasma-Based Methodologies Jennifer J. Griggs, Anne F. Schott, Catherine Van Poznak, Daniel F. Hayes, Ellen M. Lavoie Smith, and Justin I. Odegaard, John J. Vincent, Stefanie Mortimer, N. Lynn Henry James V. Vowles, Bryan C. Ulrich, Kimberly C. Banks, Stephen R. Fairclough, Oliver A. Zill, Marcin Sikora, Reza Mokhtari, Diana Abdueva, Rebecca J. Nagy, Christine E. Lee, Lesli A. Kiedrowski, Cloud P. Paweletz, TRANSLATIONAL CANCER MECHANISMS Helmy Eltoukhy, Richard B. Lanman, Darya I. Chudova, AND THERAPY and AmirAli Talasaz 3611 3550 Exome Sequencing of Plasma DNA Portrays the A Rationally Designed Fully Human EGFRvIII: Mutation Landscape of Colorectal Cancer and CD3-Targeted Bispecific Antibody Redirects Discovers Mutated VEGFR2 Receptors as Human T Cells to Treat Patient-derived Modulators of Antiangiogenic Therapies Intracerebral Malignant Glioma Rodrigo A. Toledo, Elena Garralda, Maria Mitsi, Patrick C. Gedeon, Teilo H. Schaller, Satish K. Chitneni, Bryan D. Choi, Chien-Tsun Kuan, Carter M. Suryadevara, Tirso Pons, Jorge Monsech, Estela Vega, Alvaro Otero, David J. Snyder, Robert J. Schmittling, Scott E. Szafranski, Maria I. Albarran, Natalia Banos,~ Yolanda Duran, Xiuyu Cui, Patrick N. Healy, James E. Herndon II, Victoria Bonilla, Francesca Sarno, Roger E. McLendon, Stephen T. Keir, Gary E. Archer, Marta Camacho-Artacho, Tania Sanchez-Perez, Elizabeth A. Reap, Luis Sanchez-Perez, Darell D. Bigner, Sofia Perea, Rafael Alvarez, Alba De Martino, and John H. Sampson Daniel Lietha, Carmen Blanco-Aparicio, Antonio Cubillo, Orlando Domínguez, Jorge L. Martínez-Torrecuadrada, 3632 and Manuel Hidalgo Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma 3560 Immunogenomic Analyses of Advanced Serous Pravin Kesarwani, Antony Prabhu, Shiva Kant, Ovarian Cancer Reveal Immune Score is a Strong Praveen Kumar, Stewart F. Graham, Katie L. Buelow, Prognostic Factor and an Indicator of George D. Wilson, C. Ryan Miller, and Chemosensitivity Prakash Chinnaiyan Dapeng Hao, Jie Liu, Meng Chen, JingJing Li, Li Wang, Xiaobo Li, Qi Zhao, and Li-jun Di 3644 Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell 3572 Intraoperative Resection Guidance with Polyomavirus Photoacoustic and Fluorescence Molecular Ioannis Gavvovidis, Matthias Leisegang, Imaging Using an Anti–B7-H3 Antibody- Gerald Willimsky, Natalie Miller, Paul Nghiem, and Indocyanine Green Dual Contrast Agent Thomas Blankenstein Katheryne E. Wilson, Sunitha V. Bachawal, and Jurgen€ K. Willmann 3656 Enhanced Therapeutic Activity of Non- Internalizing Small-Molecule-Drug Conjugates 3583 A New Approach to Predict Progression-free Targeting Carbonic Anhydrase IX in Survival in Stage IV EGFR-mutant NSCLC Patients Combination with Targeted Interleukin-2 with EGFR-TKI Therapy Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, Jiangdian Song, Jingyun Shi, Di Dong, Mengjie Fang, Patrizia Murer, Giovanni Pellegrini, Francesca Pretto, Wenzhao Zhong, Kun Wang, Ning Wu, Yanqi Huang, Sarah Wulhfard, and Dario Neri Zhenyu Liu, Yue Cheng, Yuncui Gan, Yongzhao Zhou, Ping Zhou, Bojiang Chen, Changhong Liang, Zaiyi Liu, Weimin Li, and Jie Tian

3668 MEIS1 and MEIS2 Expression and Prostate 3741 Neddylation Blockade Diminishes Hepatic Cancer Progression: A Role For HOXB13 Binding Metastasis by Dampening Cancer Stem-Like Partners in Metastatic Disease Cells and Angiogenesis in Uveal Melanoma Raj R. Bhanvadia, Calvin VanOpstall, Hannah Brechka, Yanli Jin, Ping Zhang, Yun Wang, Bei Jin, Jingfeng Zhou, Nimrod S. Barashi, Marc Gillard, Erin M. McAuley, Jing Zhang, and Jingxuan Pan Juan Manuel Vasquez, Gladell Paner, Wen-Ching Chan, See related commentary, p. 3477 Jorge Andrade, Angelo M. De Marzo, Misop Han, Russell Z. Szmulewitz, and Donald J. Vander Griend 3755 Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with 3681 BQ323636.1, a Novel Splice Variant to NCOR2, as Cisplatin Resistance and Identify PDMP as a a Predictor for Tamoxifen-Resistant Breast Resensitizing Agent Cancer Josep M. Piulats, August Vidal, Chun Gong, Ellen P.S. Man, Ho Tsoi, Terence K.W. Lee, Francisco J. García-Rodríguez, Clara Munoz,~ Marga Nadal, Paul Lee, Sai-Ting Ma, Lai-San Wong, Mai-Yee Luk, Catia Moutinho, María Martínez-Iniesta, Josefina Mora, Emad A. Rakha, Andrew R. Green, Ian O. Ellis, Agnes Figueras, Elisabet Guino, Laura Padulles, Eric W.-F. Lam, Kwok-Leung Cheung, and Ui-Soon Khoo Alvaro Aytes, David G. Molleví, Sara Puertas, See related commentary, p. 3480 Carmen Martínez-Fernandez, Wilmar Castillo, Merce Juliachs, Victor Moreno, Purificacion Munoz,~ 3692 Epigenome-wide SRC-1–Mediated Gene Milica Stefanovic, Miguel A. Pujana, Enric Condom, Silencing Represses Cellular Differentiation in Manel Esteller, Josep R. Germa, Gabriel Capella, Advanced Breast Cancer Lourdes Farre, Albert Morales, Francesc Vinals,~ Elspeth Ward, Damir Varešlija, Sara Charmsaz, Xavier García-del-Muro, Julian Ceron, and Ailis Fagan, Alacoque L. Browne, Nicola Cosgrove, Alberto Villanueva Sinead Cocchiglia, Siobhan P. Purcell, Lance Hudson, Sudipto Das, Darran O'Connor, Philip J. O'Halloran, 3767 Phenformin-Induced Mitochondrial Dysfunction Andrew H. Sims, Arnold D. Hill, and Leonie S. Young Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR 3704 Insulin-Like Growth Factor 2 mRNA-Binding Sonia R. Veiga, Xuemei Ge, Carol A. Mercer, Protein 3 is a Novel Post-Transcriptional María I. Hernandez-Alvarez, Hala Elnakat Thomas, Regulator of Ewing Sarcoma Malignancy Javier Hernandez-Losa, Santiago Ramon y Cajal, Caterina Mancarella, Michela Pasello, Selena Ventura, Antonio Zorzano, George Thomas, and Sara C. Kozma Andrea Grilli, Linda Calzolari, Lisa Toracchio, Pier-Luigi Lollini, Davide Maria Donati, Piero Picci, Stefano Ferrari, and Katia Scotlandi CORRECTIONS 3717 A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune 3781 Correction: A Phase II Study of Gefitinib Cell Populations for Aggressive Cutaneous Squamous Cell David Tamborero, Carlota Rubio-Perez, Ferran Muinos,~ Carcinoma of the Head and Neck Radhakrishnan Sabarinathan, Josep M. Piulats, Aura Muntasell, Rodrigo Dienstmann, Nuria Lopez-Bigas, 3782 Correction: PI3K Inhibition Reduces Mammary and Abel Gonzalez-Perez Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses 3729 Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo RETRACTION Viktoria Laszlo, Zsuzsanna Valko, Ildiko Kovacs, Judit Ozsvar, Mir Alireza Hoda, Thomas Klikovits, 3783 Retraction: Update on the Application of Dora Lakatos, Andras Czirok, Tamas Garay, Interleukin-2 in the Treatment of Renal Alexander Stiglbauer, Thomas H. Helbich, Marion Groger,€ Cell Carcinoma Jozsef Tovari, Walter Klepetko, Christine Pirker, Michael Grusch, Walter Berger, Frank Hilberg, Balazs Hegedus, and Balazs Dome

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ABOUT THE COVER

The cover shows a section of CT-2A murine glioma cells 6 days post orthotopic implantation. Hematoxylin and eosin staining reveals a highly invasive tumor infiltrating the brain parenchyma. For details, see the article by Gedeon and colleagues on page 3611 of this issue.

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Clin Cancer Res 2018;24:3475-3783.

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