Toward Long Distance, Sub-Diffraction Imaging Using Coherent Camera Arrays
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Subwavelength Resolution Fourier Ptychography with Hemispherical Digital Condensers
Subwavelength resolution Fourier ptychography with hemispherical digital condensers AN PAN,1,2 YAN ZHANG,1,2 KAI WEN,1,3 MAOSEN LI,4 MEILING ZHOU,1,2 JUNWEI MIN,1 MING LEI,1 AND BAOLI YAO1,* 1State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China 2University of Chinese Academy of Sciences, Beijing 100049, China 3College of Physics and Information Technology, Shaanxi Normal University, Xi’an 710071, China 4Xidian University, Xi’an 710071, China *[email protected] Abstract: Fourier ptychography (FP) is a promising computational imaging technique that overcomes the physical space-bandwidth product (SBP) limit of a conventional microscope by applying angular diversity illuminations. However, to date, the effective imaging numerical aperture (NA) achievable with a commercial LED board is still limited to the range of 0.3−0.7 with a 4×/0.1NA objective due to the constraint of planar geometry with weak illumination brightness and attenuated signal-to-noise ratio (SNR). Thus the highest achievable half-pitch resolution is usually constrained between 500−1000 nm, which cannot fulfill some needs of high-resolution biomedical imaging applications. Although it is possible to improve the resolution by using a higher magnification objective with larger NA instead of enlarging the illumination NA, the SBP is suppressed to some extent, making the FP technique less appealing, since the reduction of field-of-view (FOV) is much larger than the improvement of resolution in this FP platform. Herein, in this paper, we initially present a subwavelength resolution Fourier ptychography (SRFP) platform with a hemispherical digital condenser to provide high-angle programmable plane-wave illuminations of 0.95NA, attaining a 4×/0.1NA objective with the final effective imaging performance of 1.05NA at a half-pitch resolution of 244 nm with a wavelength of 465 nm across a wide FOV of 14.60 mm2, corresponding to an SBP of 245 megapixels. -
Near-Field Fourier Ptychography: Super- Resolution Phase Retrieval Via Speckle Illumination
Near-field Fourier ptychography: super- resolution phase retrieval via speckle illumination HE ZHANG,1,4,6 SHAOWEI JIANG,1,6 JUN LIAO,1 JUNJING DENG,3 JIAN LIU,4 YONGBING ZHANG,5 AND GUOAN ZHENG1,2,* 1Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA 2Electrical and Computer Engineering, University of Connecticut, Storrs, CT, 06269, USA 3Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA. 4Ultra-Precision Optoelectronic Instrument Engineering Center, Harbin Institute of Technology, Harbin 150001, China 5Shenzhen Key Lab of Broadband Network and Multimedia, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China 6These authors contributed equally to this work *[email protected] Abstract: Achieving high spatial resolution is the goal of many imaging systems. Designing a high-resolution lens with diffraction-limited performance over a large field of view remains a difficult task in imaging system design. On the other hand, creating a complex speckle pattern with wavelength-limited spatial features is effortless and can be implemented via a simple random diffuser. With this observation and inspired by the concept of near-field ptychography, we report a new imaging modality, termed near-field Fourier ptychography, for tackling high- resolution imaging challenges in both microscopic and macroscopic imaging settings. The meaning of ‘near-field’ is referred to placing the object at a short defocus distance with a large Fresnel number. In our implementations, we project a speckle pattern with fine spatial features on the object instead of directly resolving the spatial features via a high-resolution lens. We then translate the object (or speckle) to different positions and acquire the corresponding images using a low-resolution lens. -
Arxiv:1707.05927V1 [Physics.Med-Ph] 19 Jul 2017
Medical image reconstruction: a brief overview of past milestones and future directions Jeffrey A. Fessler University of Michigan July 20, 2017 At ICASSP 2017, I participated in a panel on “Open Problems in Signal Processing” led by Yonina Eldar and Alfred Hero. Afterwards the editors of the IEEE Signal Processing Magazine asked us to write a “perspectives” column on this topic. I prepared the text below but later found out that equations or citations are not the norm in such columns. Because I had already gone to the trouble to draft this version with citations, I decided to post it on arXiv in case it is useful for others. Medical image reconstruction is the process of forming interpretable images from the raw data recorded by an imaging system. Image reconstruction is an important example of an inverse problem where one wants to determine the input to a system given the system output. The following diagram illustrates the data flow in an medical imaging system. Image Object System Data Images Image −−−−−→ −−−→ reconstruction −−−−−→ → ? x (sensor) y xˆ processing (estimator) Until recently, there have been two primary methods for image reconstruction: analytical and iterative. Analytical methods for image reconstruction use idealized mathematical models for the imaging system. Classical examples are the filtered back- projection method for tomography [1–3] and the inverse Fourier transform used in magnetic resonance imaging (MRI) [4]. Typically these methods consider only the geometry and sampling properties of the imaging system, and ignore the details of the system physics and measurement noise. These reconstruction methods have been used extensively because they require modest computation. -
Arxiv:2007.14139V2 [Physics.Optics] 1 Apr 2021 Plane and the Detector Plane
Accelerating ptychographic reconstructions using spectral initializations Lorenzo Valzania,1, 2, ∗ Jonathan Dong,1, 3, ∗ and Sylvain Gigan1 1Laboratoire Kastler Brossel, Ecole´ Normale Sup´erieure - Paris Sciences et Lettres (PSL) Research University, Sorbonne Universit´e,Centre National de la Recherche Scientifique (CNRS) UMR 8552, Coll`egede France, 24 rue Lhomond, 75005 Paris, France 2Laboratory for Transport at Nanoscale Interfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, 129 Uberlandstrasse, Dubendorf 8600, Switzerland 3Laboratoire de Physique de l'Ecole´ Normale Sup´erieure - Paris Sciences et Lettres (PSL) Research University, Sorbonne Universit´e,CNRS, Universit´ede Paris, 24 rue Lhomond, 75005 Paris, France (Dated: April 2, 2021) Ptychography is a promising phase retrieval technique for label-free quantitative phase imaging. Recent advances in phase retrieval algorithms witnessed the development of spectral methods, in order to accelerate gradient descent algorithms. Using spectral initializations on experimental data, for the first time we report three times faster ptychographic reconstructions than with a standard gradient descent algorithm and improved resilience to noise. Coming at no additional computational cost compared to gradient-descent-based algorithms, spectral methods have the potential to be implemented in large-scale iterative ptychographic algorithms. I. INTRODUCTION and the acquisition parameters. The quest for improved reconstruction performance culminated in the derivation Ptychography is a computational imaging technique of optimal spectral methods for the random measure- that enables label-free, quantitative phase imaging [1]. ments setting [9, 10]. Due to these breakthroughs, spec- It is based on a simple principle: scan a probe across tral methods for phase retrieval are rather well under- a sample, collect the corresponding intensity diffraction stood theoretically. -
Sub-Diffraction Imaging Using Fourier Ptychography and Structured Sparsity
SUB-DIFFRACTION IMAGING USING FOURIER PTYCHOGRAPHY AND STRUCTURED SPARSITY Gauri Jagatap, Zhengyu Chen, Chinmay Hegde, Namrata Vaswani Electrical and Computer Engineering, Iowa State University, Ames, IA 50011 ABSTRACT fewer samples suffice. The assumption of sparsity is natural in sev- eral applications in imaging systems, such as sub-diffraction imag- We consider the problem of super-resolution for sub-diffraction ing, X-ray crystallography, bio-imaging and astronomical imaging imaging. We adapt conventional Fourier ptychographic approaches, [12, 13, 14]; in these applications, the object to be imaged is often for the case where the images to be acquired have an underlying modeled as sparse in the canonical (or wavelet) basis. structured sparsity. We propose some subsampling strategies which Moving beyond sparsity, several algorithms that leverage more can be easily adapted to existing ptychographic setups. We then refined structured sparsity modeling assumptions (such as block use a novel technique called CoPRAM with some modifications, sparsity) achieve considerably improved sample-complexity for re- to recover sparse (and block sparse) images from subsampled pty- constructing images from compressive measurements [15, 16, 17]. chographic measurements. We demonstrate experimentally that this However, analogous algorithms in the context of phase retrieval are algorithm performs better than existing phase retrieval techniques, in not well-studied. In recent previous work [18], we have developed terms of quality of reconstruction, using fewer number of samples. a theoretically-sound algorithmic approach for phase retrieval that Index Terms— Phase retrieval, ptychography, sparsity, non- integrate sparsity (as well as structured sparsity) modeling assump- convex algorithms tions within the reconstruction process. However, that work also assumes certain stringent probabilistic assumptions on the measure- 1. -
This Is a Repository Copy of Ptychography. White Rose
This is a repository copy of Ptychography. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/127795/ Version: Accepted Version Book Section: Rodenburg, J.M. orcid.org/0000-0002-1059-8179 and Maiden, A.M. (2019) Ptychography. In: Hawkes, P.W. and Spence, J.C.H., (eds.) Springer Handbook of Microscopy. Springer Handbooks . Springer . ISBN 9783030000684 https://doi.org/10.1007/978-3-030-00069-1_17 This is a post-peer-review, pre-copyedit version of a chapter published in Hawkes P.W., Spence J.C.H. (eds) Springer Handbook of Microscopy. The final authenticated version is available online at: https://doi.org/10.1007/978-3-030-00069-1_17. Reuse Items deposited in White Rose Research Online are protected by copyright, with all rights reserved unless indicated otherwise. They may be downloaded and/or printed for private study, or other acts as permitted by national copyright laws. The publisher or other rights holders may allow further reproduction and re-use of the full text version. This is indicated by the licence information on the White Rose Research Online record for the item. Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing [email protected] including the URL of the record and the reason for the withdrawal request. [email protected] https://eprints.whiterose.ac.uk/ Ptychography John Rodenburg and Andy Maiden Abstract: Ptychography is a computational imaging technique. A detector records an extensive data set consisting of many inference patterns obtained as an object is displaced to various positions relative to an illumination field. -
Low-Rank Fourier Ptychography
LOW RANK FOURIER PTYCHOGRAPHY Zhengyu Chen, Gauri Jagatap, Seyedehsara Nayer, Chinmay Hegde, Namrata Vaswani Iowa State University ABSTRACT reconstruction problem is nascent, and several important questions remain unanswered. Rigorous guarantees of correctness of the meth- In this paper, we introduce a principled algorithmic approach for ods proposed in [8, 10] are not yet available. More worrisome is the Fourier ptychographic imaging of dynamic, time-varying targets. To issue of sample complexity of image reconstruction, since a basic the best of our knowledge, this setting has not been explicitly ad- requirement in all existing methods is that the number of measure- dressed in the ptychography literature. We argue that such a setting ments must exceed the resolution of the image. However, this re- is very natural, and that our methods provide an important first step quirement can be particularly challenging when imaging a dynamic towards helping reduce the sample complexity (and hence acquisi- scene involving a moving target; for a video sequence with q images tion time) of imaging dynamic scenes to managaeble levels. With each with resolution n, without using any structural prior assump- significantly reduced acquisition times per image, it is conceivable tions, the number of observations must be at least Ω(nq), which can that dynamic ptychographic imaging of fast changing scenes indeeed quickly become prohibitive. becomes practical in the near future. Index Terms— Phase retrieval, ptychography, low rank 1.2. Our Contributions 1. INTRODUCTION In this paper, we introduce a principled algorithmic approach for Fourier ptychographic imaging of dynamic, time-varying targets. To 1.1. Motivation the best of our knowledge, this setting has not been explicitly ad- dressed in the ptychography literature. -
Phase Retrieval for Fourier Ptychography Under Varying Amount of Measurements
BOOMINATHAN ET AL.: PHASE RETRIEVAL FOR FOURIER PTYCHOGRAPHY 1 Phase retrieval for Fourier Ptychography under varying amount of measurements Lokesh Boominathan12 1 Computational Imaging Lab, [email protected] Indian Institute of Technology Madras, Mayug Maniparambil1 Chennai, India [email protected] 2 Aindra Systems Honey Gupta1 Bengaluru, India [email protected] Rahul Baburajan1 [email protected] Kaushik Mitra1 [email protected] Abstract Fourier Ptychography is a recently proposed imaging technique that yields high- resolution images by computationally transcending the diffraction blur of an optical system. At the crux of this method is the phase retrieval algorithm, which is used for computationally stitching together low-resolution images taken under varying illumina- tion angles of a coherent light source. However, the traditional iterative phase retrieval technique relies heavily on the initialization and also needs a good amount of overlap in the Fourier domain for the successively captured low-resolution images, thus increas- ing the acquisition time and data. We show that an auto-encoder based architecture can be adaptively trained for phase retrieval under both low overlap, where traditional tech- niques completely fail, and at higher levels of overlap. For the low overlap case we show that a supervised deep learning technique using an autoencoder generator is a good choice for solving the Fourier ptychography problem. And for the high overlap case, we show that optimizing the generator for reducing the forward model error is an appropriate choice. Using simulations for the challenging case of uncorrelated phase and amplitude, we show that our method outperforms many of the previously proposed Fourier ptychog- raphy phase retrieval techniques. -
Sample Efficient Fourier Ptychography for Structured Data
1 Sample Efficient Fourier Ptychography for Structured Data Gauri Jagatap, Zhengyu Chen, Seyedehsara Nayer, Chinmay Hegde, Senior Member, IEEE and Namrata Vaswani, Fellow, IEEE Abstract—We study the problem of recovering structured data shifts induced by the optical lens setup. However, the sensing from Fourier ptychography measurements. Fourier ptychogra- apparatus is incapable of estimating the phase of the complex phy is an image acquisition scheme that uses an array of images values, and only the magnitudes can be measured. to produce high-resolution images in microscopy as well as long- distance imaging, to mitigate the effects of diffraction blurring. This setup can be molded to that of the classical problem The number of measurements is typically much larger than the of phase retrieval [7], [8], [9], which is a non-linear, ill- size of the signal (image or video) to be reconstructed, which posed inverse problem. In phase retrieval, the goal is to recon- translates to high storage and computational requirements. struct a discretized image (or video) of size n (or nq) from The issue of high sample complexity can be alleviated by utiliz- noisy, magnitude-only observations of the image’s discrete ing structural properties of the image (or video). In this paper, we first discuss a range of sub-sampling schemes which can reduce Fourier transform (DFT) coefficients. A generalized version the amount of measurements in Fourier ptychography setups; of this problem replaces the DFT coefficients with a generic however, this makes the problem ill-posed. Correspondingly, we linear operator constructed by sampling certain families of impose structural constraints on the signals to be recovered, probability distributions. -
REFLECTIVE MODE FOURIER PTYCHOGRAPHY by Basel
REFLECTIVE MODE FOURIER PTYCHOGRAPHY by Basel Salahieh Committee Members Rongguang Liang (Chair), Jeffrey Rodriguez (Member), Tom Milster (Member) __________________________ Copyright © Basel Salahieh 2015 A Master’s Report Submitted to the College of the OPTICAL SCIENCES In Partial Fulfillment of the Requirements For the Degree of MASTER OF SCIENCE In the Graduate College THE UNIVERSITY OF ARIZONA 2015 Table of Contents List of Figures ................................................................................................................................. 3 Abstract ........................................................................................................................................... 4 Overview of Reflective Imaging Systems ...................................................................................... 5 Background in Optics ................................................................................................................. 5 Limitations of Conventional Imaging Systems........................................................................... 6 Introduction to Fourier Ptychography ............................................................................................. 7 Algorithm .................................................................................................................................... 7 Simulating the Iterative FP Algorithm ........................................................................................ 9 Case Studies on Selected FP Parameters ................................................................................. -
Computational Imaging for VLBI Image Reconstruction
Computational Imaging for VLBI Image Reconstruction Katherine L. Bouman1 Michael D. Johnson2 Daniel Zoran1 Vincent L. Fish3 Sheperd S. Doeleman2;3 William T. Freeman1;4 1Massachusetts Institute of Technology, CSAIL 2Harvard-Smithsonian Center for Astrophysics 3MIT Haystack Observatory 4Google Abstract Very long baseline interferometry (VLBI) is a technique for imaging celestial radio emissions by simultaneously ob- serving a source from telescopes distributed across Earth. The challenges in reconstructing images from fine angular resolution VLBI data are immense. The data is extremely sparse and noisy, thus requiring statistical image models such as those designed in the computer vision community. In this paper we present a novel Bayesian approach for VLBI image reconstruction. While other methods often re- (a) Telescope Locations (b) Spatial Frequency Coverage quire careful tuning and parameter selection for different Figure 1. Frequency Coverage: (A) A sample of the telescope locations types of data, our method (CHIRP) produces good results in the EHT. By observing a source over the course of a day, we obtain mea- under different settings such as low SNR or extended emis- surements corresponding to elliptical tracks in the source image’s spatial sion. The success of our method is demonstrated on realis- frequency plane (B). These frequencies, (u; v), are the projected baseline lengths orthogonal to a telescope pair’s light of sight. Points of the same tic synthetic experiments as well as publicly available real color correspond to measurements from the same telescope pair. data. We present this problem in a way that is accessible to members of the community, and provide a dataset website a lack of inverse modeling [36], resulting in sub-optimal im- (vlbiimaging.csail.mit.edu) that facilitates con- ages. -
Deep Learning in Biomedical Optics
Deep learning in biomedical optics Lei Tian,1* Brady Hunt,2 Muyinatu A. Lediju Bell,3,4,5 Ji Yi,4,6 Jason T. Smith,7 Marien Ochoa,7 Xavier Intes,7 Nicholas J. Durr3,4* 1Department of Electrical and Computer Engineering, Boston University, Boston, MA, USA 2Thayer School of Engineering, Dartmouth College, Hanover, NH, USA 3Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA 5Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA 6Department of Ophthalmology, Johns Hopkins University, Baltimore, MD, USA 7Center for Modeling, Simulation, and Imaging in Medicine, Rensselaer Polytechnic Institute *Corresponding author: L. Tian, [email protected]; N.J. Durr, [email protected] This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imag- ing, in vivo microscopy, widefield endoscopy, optical coher- ence tomography, photoacoustic imaging, diffuse tomogra- phy, and functional optical brain imaging. For each of these domains, we summarize how deep learning has been ap- plied and highlight methods by which deep learning can enable new capabilities for optics in medicine. Challenges and opportunities to improve translation and adoption of Fig 1: Number of reviewed research papers which utilize DL deep learning in biomedical optics are also