Researchers devise a way to manipulate a rat's 6 September 2012, by Bob Yirka

to alter the action by controlling the real world environment that surrounds some test rats as they slept; to find out, they devised a simple experiment. First they taught a rat running through a maze to respond to two different audio tones. The first meant they'd find a treat if they turned right, the second meant they'd find a treat if they turned left. After the rats had it down, the research duo recorded their brain wave patterns as they ran through the maze and responded to the tones. Later, after the rats had bedded down for the night and were dreaming, their brain wave patterns were recorded again, this time to show what they knew the rats would be dreaming about; the maze of course. Comparing the brain waves from the actual maze runs to those that occurred while the rats were sleeping showed this to be true. Then, to alter the rats' dreams, the researchers played the same audio tones that had been used in the maze tests, and found that the brain waves of the rats (Medical Xpress)—Cognitive scientists working at responded in the same way as they had when the MIT have devised a means for not only altering the rats were awake and in the maze, proving that the dreams of rats, but of demonstrating a way of audio tones had influenced their dreams in a testing what they've achieved, offering evidence directly controlled manner. that it can be done, and in so doing have offered a glimpse into what may lie ahead for people who Due to their findings, the researchers speculate that wish to manipulate their own dreams. Daniel maybe someday soon there will be a new kind of Bendor and Matthew Wilson, working out of MIT's science, i.e. engineering, where scientists Picower Institute for Learning and have, learn all manner of ways to manipulate dreams in as they describe in their paper published in Nature people, and then people use those techniques to Neuroscience, used audio sounds to influence the customize their dreams to conjure up whatever it is dreams of rats they were studying. they can imagine, and possibly, to eliminate nightmares. Dreams, like gravity and reasons for our existence, are not understood at all. Nobody knows why we More information: Biasing the content of have them or what we get from them, though there hippocampal replay during , Nature are countless theories. And until now, most would Neuroscience (2012) doi:10.1038/nn.3203 have agreed that dreams are a phenomenon all their own; we, as the dreamers, are merely passive Abstract viewers, watching and responding emotionally to The is essential for encoding self- the events as they unfold, but powerless to control experienced events into memory. During sleep, the action. neural activity in the hippocampus related to a recent experience has been observed to Bendor and Wilson thought maybe it was possible spontaneously reoccur, and this 'replay' has been

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postulated to be important for . Task-related cues can enhance memory consolidation when presented during a post-training sleep session, and, if are consolidated by hippocampal replay, a specific enhancement for this replay should be observed. To test this, we trained rats on an auditory-spatial association task while recording from neuronal ensembles in the hippocampus. We found that, during sleep, a task-related auditory cue biased reactivation events toward replaying the spatial memory associated with that cue. These results indicate that sleep replay can be manipulated by external stimulation and provide further evidence for the role of hippocampal replay in memory consolidation.

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