ARIC V5 / NCS Code Book II, S.2 Page 1 of 6 ______Section 2: Central Agency Files

Retinal Preliminary Data - Right Eye: FORM CODE=RETP0 VERSION=1.0 Instructions: File contains the preliminary grading data for the participant's right eye.

Retinal Preliminary Data - Right Eye (RETP0)

Vers Vers

N Value Description 2628 0100

EventName EventName

N Value Description 2628 CSCC

Occurrence Occurrence

N Value Description 2628 1

RETP01 ARIC patient identifier

N Value Description 2628 Present Text suppressed

RETP02 ARIC patient acrostic ID

N Value Description 2628 X

RETP03 Right Eye

N Value Description 2628 Range 0 - 0 ( median=0 mean=0.0 std=0.0 )

RETP04 Visit Date

N Value Description 2579 Range 06JUL11:00:00:00 - 30OCT13:00:00:00 49 Missing

RETP05 ARIC exam phase

N Value Description 2628 Range 8 - 8 ( median=8 mean=8.0 std=0.0 )

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 2 of 6 ______Section 2: Central Agency Files

RETP06 Site name

N Value Description 2628 Present Text suppressed

RETP07 Photos

N Value Description 2628 Range 0 - 2 ( median=2 mean=1.9 std=0.3 )

RETP08 Photographer's Last Name

N Value Description 2628 Present Text suppressed

RETP09 date Received

N Value Description 2628 Range 18JUL11:00:00:00 - 31OCT13:00:00:00

RETP010 Date Graded

N Value Description 2584 Range 19JUL11:00:00:00 - 04NOV13:00:00:00 44 Missing

RETP011 Date of Pathology Report

N Value Description 28 Range 19JUL11:00:00:00 - 19JUL13:00:00:00 2600 Missing

RETP012 Reason for Pathology Notification

N Value Description 2555 0 No Pathology Reported 13 1 Large C/D Ratio Plus 2 4 Any (CSME or ME) 2 5 Branch Vein Occlusion / Central Vein Occlusion 3 6 Treatable Age-Related Maculopathy 5 7 Hollenhorst Plaque 3 99 Other 1 999 No photos taken for the eye 44 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 3 of 6 ______Section 2: Central Agency Files

RETP013 Photo Field 1 present

N Value Description 45 0 No 2538 2 Yes 1 9 No photos 44 Missing

RETP014 Photo Field 2 present

N Value Description 111 0 No 2472 2 Yes 1 9 No photos 44 Missing

RETP015 Photo Gradability

N Value Description 1476 0 All fields gradable 11 1 Disc ungradable 777 2 Portion of macula ungradable 262 3 Macula is ungradable 6 4 Portion of Disc and Macula Ungradable 43 5 Disc and Macula are ungradable 8 6 All fields ungradable 1 9 No photos taken for the eye 44 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 4 of 6 ______Section 2: Central Agency Files

RETP016 Diabetic Level

N Value Description 1 9 No photos taken for this eye 1940 10 DR Absent 32 12 Non-diabetic 75 13 Questionable 6 14 HE, SE, IRMA, without Microaneurysms 44 15 Hem only with no Microaneurysms 68 20 Microaneurysms only 31 31 Early Non-Proliferative 9 41 Moderate Non-Proliferative Diabetic Retinopathy 1 60 Fibrous Proliferation only 2 61 No retinopathy, with treatment 2 62 MAs only, with treatment 3 63 Early NPDR, with treatment 370 88 Cannot Grade 44 Missing

RETP017 Macular Edema

N Value Description 2197 0 None 5 1 Questionable 5 2 Present, not CSME 1 3 Present, CSME 375 8 Cannot Grade 1 9 No photos taken for the eye 44 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 5 of 6 ______Section 2: Central Agency Files

RETP018 ARM_Feedback (used in sending participant results only)

N Value Description 2023 0 No ARM 67 1 Drusen Only 80 2 Early ARM 42 3 Late ARM 68 7 Excluded for ARM 303 8 Cannot Grade 1 9 No photos taken for the eye 44 Missing

RETP018a Vasc_BVO_CVO_Prelim

N Value Description 2358 0 None 7 1 Questionable 10 2 Present 208 8 Cannot Grade 1 9 No photos taken for the eye 44 Missing

RETP019 Hollenhorst Plaque

N Value Description 2338 0 None 4 1 Questionable 5 2 Present 236 8 Cannot Grade 1 9 No photos taken for the eye 44 Missing

RETP020 Macular Hole

N Value Description 2157 0 None 6 1 Questionable 6 2 Present 414 8 Cannot Grade 1 9 No photos taken for the eye 44 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 6 of 6 ______Section 2: Central Agency Files

RETP021 Large Cup to Disc Ratio greater than or equal to .7

N Value Description 2176 0 None 211 1 Questionable 118 2 Present 78 8 Cannot Grade 1 9 No photos taken for the eye 44 Missing

RETP022 Choroidal Nevus

N Value Description 2213 0 None 30 1 Questionable 81 2 Present 259 8 Cannot Grade 1 9 No photos taken for the eye 44 Missing

RETP023 Traction from Surface Wrinkling Retinopathy

N Value Description 2088 0 None 22 1 Questionable 59 2 Present 414 8 Cannot Grade 1 9 No photos taken for the eye 44 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 1 of 7 ______Section 2: Central Agency Files

Retinal Preliminary Data - Left Eye: FORM CODE=RETP1 VERSION=1.0 Instructions: File contains the preliminary grading data for the participant's left eye.

Retinal Preliminary Data - Left Eye (RETP1)

Vers Vers

N Value Description 2628 0100

EventName EventName

N Value Description 2628 CSCC

Occurrence Occurrence

N Value Description 2628 1

RETP11 ARIC patient identifier

N Value Description 2628 Present Text suppressed

RETP12 ARIC patient acrostic ID

N Value Description 2628 X

RETP13 Left Eye

N Value Description 2628 Range 1 - 1 ( median=1 mean=1.0 std=0.0 )

RETP14 Visit Date

N Value Description 2628 Range 06JUL11:00:00:00 - 30OCT13:00:00:00

RETP15 ARIC exam phase

N Value Description 2628 Range 8 - 8 ( median=8 mean=8.0 std=0.0 )

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 2 of 7 ______Section 2: Central Agency Files

RETP16 Site name

N Value Description 2628 Present Text suppressed

RETP17 Photos

N Value Description 2628 Range 0 - 2 ( median=2 mean=1.9 std=0.4 )

RETP18 Photographer's Last Name

N Value Description 2628 Present Text suppressed

RETP19 date Received

N Value Description 2628 Range 18JUL11:00:00:00 - 31OCT13:00:00:00

RETP110 Date Graded

N Value Description 2574 Range 19JUL11:00:00:00 - 04NOV13:00:00:00 54 Missing

RETP111 Date of Pathology Report

N Value Description 28 Range 19JUL11:00:00:00 - 14AUG13:00:00:00 2600 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 3 of 7 ______Section 2: Central Agency Files

RETP112 Reason for Pathology Notification

N Value Description 2546 0 No Pathology Reported 11 1 Large C/D Ratio Plus 2 4 Any Macular Edema (CSME or ME) 2 5 Branch Vein Occlusion / Central Vein Occlusion 6 6 Treatable Age-Related Maculopathy 4 7 Hollenhorst Plaque 2 9 Macular Hole 1 99 Other 3 999 No photos taken for the eye 51 Missing

RETP113 Photo Field 1 present

N Value Description 37 0 No 2537 2 Yes 3 9 No photos 51 Missing

RETP114 Photo Field 2 present

N Value Description 112 0 No 2462 2 Yes 3 9 No photos 51 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 4 of 7 ______Section 2: Central Agency Files

RETP115 Photo Gradability

N Value Description 1487 0 All fields gradable 7 1 Disc ungradable 747 2 Portion of macula ungradable 271 3 Macula is ungradable 4 4 Portion of Disc and Macula Ungradable 49 5 Disc and Macula are ungradable 9 6 All fields ungradable 3 9 No photos taken for the eye 51 Missing

RETP116 Diabetic Retinopathy Level

N Value Description 3 9 No photos taken for this eye 1916 10 DR Absent 35 12 Non-diabetic 84 13 Questionable 5 14 HE, SE, IRMA, without Microaneurysms 35 15 Hem only with no Microaneurysms 68 20 Microaneurysms only 31 31 Early Non-Proliferative Diabetic Retinopathy 12 41 Moderate Non-Proliferative Diabetic Retinopathy 2 60 Fibrous Proliferation only 1 61 No retinopathy, with treatment 2 62 MAs only, with treatment 3 63 Early NPDR, with treatment 380 88 Cannot Grade 51 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 5 of 7 ______Section 2: Central Agency Files

RETP117 Macular Edema

N Value Description 2166 0 None 5 1 Questionable 4 2 Present, not CSME 2 3 Present, CSME 1 7 Present but not diabetic 396 8 Cannot Grade 3 9 No photos taken for the eye 51 Missing

RETP118 ARM_Feedback (used in sending participant results only)

N Value Description 2035 0 No ARM 59 1 Drusen Only 69 2 Early ARM 48 3 Late ARM 70 7 Excluded for ARM 293 8 Cannot Grade 3 9 No photos taken for the eye 51 Missing

RETP118a Vasc_BVO_CVO_Prelim

N Value Description 2329 0 None 14 1 Questionable 9 2 Present 222 8 Cannot Grade 3 9 No photos taken for the eye 51 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 6 of 7 ______Section 2: Central Agency Files

RETP119 Hollenhorst Plaque

N Value Description 2317 0 None 7 1 Questionable 5 2 Present 245 8 Cannot Grade 3 9 No photos taken for the eye 51 Missing

RETP120 Macular Hole

N Value Description 2137 0 None 4 1 Questionable 6 2 Present 427 8 Cannot Grade 3 9 No photos taken for the eye 51 Missing

RETP121 Large Cup to Disc Ratio greater than or equal to .7

N Value Description 2180 0 None 191 1 Questionable 118 2 Present 85 8 Cannot Grade 3 9 No photos taken for the eye 51 Missing

RETP122 Choroidal Nevus

N Value Description 2224 0 None 25 1 Questionable 64 2 Present 261 8 Cannot Grade 3 9 No photos taken for the eye 51 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 7 of 7 ______Section 2: Central Agency Files

RETP123 Traction from Surface Wrinkling Retinopathy

N Value Description 2075 0 None 38 1 Questionable 40 2 Present 421 8 Cannot Grade 3 9 No photos taken for the eye 51 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 1 of 21 ______Section 2: Central Agency Files

Retinal Final Data - Right Eye: FORM CODE=RETF0 VERSION=1.0 Instructions: File contains the final grading data for the participant's right eye.

Retinal Final Data - Right Eye (RETF0)

Vers Vers

N Value Description 2625 0100

EventName EventName

N Value Description 2625 CSCC

Occurrence Occurrence

N Value Description 2625 1

RETF01 ARIC patient identifier, PatientCode

N Value Description 2625 Present Text suppressed

RETF02 ARIC patient acrostic ID, PatientNameCode

N Value Description 2625 X

RETF03 Right Eye

N Value Description 2625 Range 0 - 0 ( median=0 mean=0.0 std=0.0 )

RETF04 Visit Date, Visit_Date

N Value Description 2580 Range 06JUL11:00:00:00 - 30OCT13:00:00:00 45 Missing

RETF05 ARIC exam phase, Visit_Number

N Value Description 2625 Range 8 - 8 ( median=8 mean=8.0 std=0.0 )

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 2 of 21 ______Section 2: Central Agency Files

RETF06 Site name, Site_Name

N Value Description 2580 Present Text suppressed 45 Missing

RETF07 Photos present, Photos

N Value Description 45 0 No photos 137 1 Not all fields present 2443 2 All fields present

RETF08 Photographer's Last name, Photogropher_Last_Name

N Value Description 2580 Present Text suppressed 45 Missing

RETF09 Date Received, Received_Date

N Value Description 2624 Range 18JUL11:00:00:00 - 31OCT13:00:00:00 1 Missing

RETF010 Date Graded, Graded_Date

N Value Description 2625 Range 19JUL11:00:00:00 - 05NOV13:00:00:00

RETF011 Date of Pathology Report, Pathology_Date

N Value Description 29 Range 19JUL11:00:00:00 - 19JUL13:00:00:00 2596 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 3 of 21 ______Section 2: Central Agency Files

RETF012 Reason for Pathology Notification, Pathology_Reason

N Value Description 2551 0 No pathology reported 14 1 Large C/D ratio plus 2 4 Any macular edema (CSME or ME) 2 5 Branch vein occlusion / Central vein occlusion 3 6 Treatable age-related maculopathy 4 7 Hollenhorst plaque 1 9 Macular hole 3 99 Other 45 999 No photos taken for the eye

RETF013 Calculated variable for Age-related Maculopathy, ARM_Severity

N Value Description 1660 0 None 196 1 Early Stage ARM 41 2 Late Stage ARM 72 7 Eye excluded 611 8 Cannot Grade (NoPhoto) 45 9 No photos taken for this eye

RETF014 Photo Field 1 present, Photo_Field1

N Value Description 40 0 No 2540 2 Yes 45 9 No photos taken for this eye

RETF015 Photo quality assessment for Field 1 focus, Photo_Field1_Focus

N Value Description 1611 0 Good/fair 804 1 Borderline 119 2 Poor 46 8 Cannot Grade (No F1 Photo) 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 4 of 21 ______Section 2: Central Agency Files

RETF016 Photo quality assessment for Field 1 gradability, Photo_Field1_Grad

N Value Description 9 0 Field 1 ungradable 2531 2 Field 1 gradable 40 8 Cannot Grade (No F1 Photo) 45 9 No photos taken for the eye

RETF017 Photo Field 2 present, Photo_Field2

N Value Description 110 0 No 2470 2 Yes 45 9 No photos taken for this eye

RETF018 Photo quality assessment for Field 2 focus, Photo_Field2_Focus

N Value Description 1568 0 Good/fair 740 1 Borderline 163 2 Poor 109 8 Cannot Grade (No F2 Photo) 45 9 No photos taken for the eye

RETF019 Photo quality assessment for Field 2 gradability, Photo_Field2_Grad

N Value Description 31 0 Field 2 ungradable 2439 2 Field 2 gradable 110 8 Cannot Grade (No F2 Photo) 45 9 No photos taken for the eye

RETF020 Photo quality assessment for field definition, Photo_Field_Def

N Value Description 2484 0 No 96 2 Yes 45 9 No photos taken for this eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 5 of 21 ______Section 2: Central Agency Files

RETF021 Photo quality assessment, haze present, Photo_Haze

N Value Description 875 0 No 1705 2 Yes 45 9 No photos taken for this eye

RETF022 Photo quality assessment, dust or dirt present, Photo_Dust_Dirt

N Value Description 2276 0 No 304 2 Yes 45 9 No photos taken for this eye

RETF023 Photo quality assessment, lashes present, Photo_Lashes

N Value Description 2502 0 No 78 2 Yes 45 9 No photos taken for this eye

RETF024 Photo quality assessment, arc present, Photo_Arc

N Value Description 2164 0 No 416 2 Yes 45 9 No photos taken for this eye

RETF025 Photo quality assessment, color balance (images not too red), Photo_Red_Chan

N Value Description 2576 0 No 4 2 Yes 45 9 No photos taken for this eye

RETF026 Photo quality assessment, proper illumination, Photo_Illum

N Value Description 1456 0 No 1124 2 Yes 45 9 No photos taken for this eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 6 of 21 ______Section 2: Central Agency Files

RETF027 Photo quality assessment, other issues with photo, Photo_Other

N Value Description 2545 0 No 35 2 Yes 45 9 No photos taken for this eye

RETF028 Photo Gradability, Gradability

N Value Description 1476 0 All fields gradable 11 1 Disc ungradable 776 2 Portion of macula ungradable 260 3 Macula is ungradable 6 4 Portion of Disc and Macula Ungradable 43 5 Disc and Macula are ungradable 8 6 All fields ungradable 45 9 No photos taken for the eye

RETF029 Diabetic Retinopathy Level, Diab_Ret_Level

N Value Description 45 9 No photos taken for this eye 1955 10 DR Absent 23 12 Non-diabetic 68 13 Questionable 6 14 HE, SE, IRMA, without Microaneurysms 44 15 Hem only with no Microaneurysms 47 20 Microaneurysms only 30 31 Early Non-Proliferative Diabetic Retinopathy 7 41 Moderate Non-Proliferative Diabetic Retinopathy 1 60 Fibrous Proliferation only 2 61 No retinopathy, with treatment 2 62 MAs only, with treatment 4 63 Early NPDR, with treatment 391 88 Cannot Grade

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 7 of 21 ______Section 2: Central Agency Files

RETF030 Diabetic Retinopathy- Hemmorhages/Micro-aneursyms, DR_HMA

N Value Description 1965 0 None 78 1 Questionable 59 2 Definite - MA's only 62 3 Hem only 48 4 Less than standard #2A 368 8 Cannot Grade 45 9 No photos taken for the eye

RETF031 Diabetic Retinopathy - Hard Exudate, DR_HE

N Value Description 2231 0 None 6 1 Questionable 14 2 Present 329 8 Cannot Grade 45 9 No photos taken for the eye

RETF032 Diabetic Retinopathy - Soft Exudate, DR_SE

N Value Description 2257 0 None 8 1 Questionable 14 2 Present 301 8 Cannot Grade 45 9 No photos taken for the eye

RETF033 Diabetic Retinopathy- Intraretinal Microvascular Abnormalities, DR_IRMA

N Value Description 2188 0 None 8 1 Questionable 8 2 Smaller than standard #8A 1 3 Larger or equal to standard #8A 375 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 8 of 21 ______Section 2: Central Agency Files

RETF034 Diabetic Retinopathy- Venous Beading, DR_VB

N Value Description 2387 0 None 1 1 Questionable 192 8 Cannot Grade 45 9 No photos taken for the eye

RETF035 Diabetic Retinopathy- New Vessels on Disc, DR_NVD

N Value Description 2477 0 None 2 1 Questionable 101 8 Cannot Grade 45 9 No photos taken for the eye

RETF036 Diabetic Retinopathy- New Vessels Elsewhere, DR_NVE

N Value Description 2332 0 None 2 1 Questionable 246 8 Cannot Grade 45 9 No photos taken for the eye

RETF037 Diabetic Retinopthy- Fibrous Proliferation, DR_FP

N Value Description 2423 0 None 2 1 Questionable 1 2 Fibrous Proliferation elsewhere (not on disc) 1 3 Fibrous Proliferation on disc only 153 8 Cannot Grade 45 9 No photos taken for the eye

RETF038 Diabetic Retinopathy- Pre-retinal or Vitreous Hemmorhage, DR_PRH_VH

N Value Description 2450 0 None 2 1 Questionable 128 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 9 of 21 ______Section 2: Central Agency Files

RETF039 Diabetic Retinopathy- Photocoagulation Scar, DR_PC_Scar

N Value Description 2484 0 None 4 1 Questionable scar or incomplete spatter 4 2 Local PC scars exist 17 3 Scatter or PRP treatment 71 8 Cannot Grade 45 9 No photos taken for the eye

RETF040 Diabetic Retinopathy-Focal Treatment, DR_Foc_Rx

N Value Description 2436 0 None 3 1 Questionable 15 2 MAs Rx only 1 3 Grid only 5 4 MAs + Grid Rx 120 8 Cannot Grade 45 9 No photos taken for the eye

RETF041 Macular Edema, Mac_Ed

N Value Description 2175 0 None 1 1 Questionable 5 2 Present, not Clinically Signifigant ME 1 3 Present, and Clinically Signifigant ME 398 8 Cannot Grade 45 9 No photos taken for the eye

RETF042 Macular Edema in center of macula, Mac_Ctr

N Value Description 2180 0 None 1 1 Questionable 1 2 Present, not Clinically Signifigant ME 398 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 10 of 21 ______Section 2: Central Agency Files

RETF043 ARM -Reasons for being excluded from grading, ARM_Exclude

N Value Description 2471 0 None 4 1 Trauma 28 2 Laser treatment 1 3 Vessel Occlusion 4 4 Dystrophy 5 5 Myopic Deneration 2 6 Histo / Toxo 3 7 Inflammatory 13 10 RPE Change not caused by ARM 1 11 not caused by ARM 5 12 Unknown Etiology 6 15 Other Reason 37 88 Cannot Grade 45 99 No photos taken for this eye

RETF044 ARM- Drusen > 125 microns, ARM_Dru_125

N Value Description 1704 0 None 24 1 Questionable 198 2 Present 87 3 Present in center circle 72 7 Excluded from ARM 495 8 Cannot Grade 45 9 No photos taken for the eye

RETF045 ARM- Soft Distinct Drusen, ARM_Soft_Dist

N Value Description 1547 0 None 56 1 Questionable 301 2 Present 112 3 Present in center circle 72 7 Excluded from ARM 492 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 11 of 21 ______Section 2: Central Agency Files

RETF046 ARM- Soft Indistinct Drusen, ARM_Soft_Indist

N Value Description 1731 0 None 82 1 Questionable 101 2 Present 53 3 Present in center circle 72 7 Excluded from ARM 541 8 Cannot Grade 45 9 No photos taken for the eye

RETF047 ARM- Soft Drusen Area >500 microns, ARM_Soft_Area_500

N Value Description 1833 0 None 143 2 Present 19 3 Present in center circle 72 7 Excluded from ARM 513 8 Cannot Grade 45 9 No photos taken for the eye

RETF048 ARM- Increased Pigment, ARM_Incr_Pigment

N Value Description 1677 0 None 48 1 Questionable 66 2 Present 92 3 Present in center circle 88 7 Pigment Other or Excluded for ARM 609 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 12 of 21 ______Section 2: Central Agency Files

RETF049 ARM- Retinal Pigment Epithelium Depigmentation, ARM_RPE_Depig

N Value Description 1730 0 None 62 1 Questionable 43 2 Present 56 3 Present in center circle 72 7 Excluded from ARM 617 8 Cannot Grade 45 9 No photos taken for the eye

RETF050 ARM- Geographic Atrophy, ARM_Geog_Atrophy

N Value Description 2138 0 None 13 1 Questionable 9 2 Present 16 3 Present in center circle 72 7 Excluded from ARM 332 8 Cannot Grade 45 9 No photos taken for the eye

RETF051 ARM- Pigment Epithelial Detachment or Serous Detachment, ARM_PED_RD

N Value Description 2128 0 None 13 1 Questionable 3 3 Present in center circle 72 7 Excluded from ARM 364 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 13 of 21 ______Section 2: Central Agency Files

RETF052 ARM- Subretinal Hemmorhage, ARM_Subret_Hem

N Value Description 2162 0 None 5 1 Questionable 4 2 Present 1 3 Present in center circle 72 7 Excluded from ARM 336 8 Cannot Grade 45 9 No photos taken for the eye

RETF053 ARM- Subretinal New Vessels, ARM_SRNV

N Value Description 2164 0 None 3 1 Questionable 1 2 Present 1 3 Present in center circle 72 7 Excluded from ARM 339 8 Cannot Grade 45 9 No photos taken for the eye

RETF054 ARM-Subretinal Fibrous Scar, ARM_Subret_Fib_Scar

N Value Description 2161 0 None 6 1 Questionable 2 2 Present 8 3 Present in center circle 72 7 Excluded from ARM 331 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 14 of 21 ______Section 2: Central Agency Files

RETF055 ARM Treatment, ARM_Rx

N Value Description 2159 0 None 2 1 Questionable 17 2 Present 1 3 Present in center circle 72 7 Excluded from ARM 329 8 Cannot Grade 45 9 No photos taken for the eye

RETF056 ARM- Hard Drusen, ARM_Hard_Dru

N Value Description 1180 0 None 88 1 Questionable 580 2 Present 732 8 Cannot Grade 45 9 No photos taken for the eye

RETF057 Atypical ARM, ARM_Atypical

N Value Description 2144 0 No 16 2 Yes 72 7 Excluded from ARM 348 8 Cannot Grade 45 9 No photos taken for the eye

RETF058 ARM Feedback (used in sending participant results only), ARM_Feedback

N Value Description 2020 0 No ARM 67 1 Drusen Only 79 2 Early ARM 40 3 Late ARM 72 7 Excluded for ARM 302 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 15 of 21 ______Section 2: Central Agency Files

RETF059 Calculated variable for focal narrowing quadrants, CALC_Focal_Nar

N Value Description 2333 0 None 43 1 Questionable 14 2 Present in at least one quadrant 190 8 Cannot Grade 45 Missing

RETF060 Focal Narrowing Superior Temporal to Disc, Focal_Nar_ST

N Value Description 2337 0 None 12 1 Questionable 5 2 Present 226 8 Cannot Grade 45 9 No photos taken for the eye

RETF061 Focal Narrowing Superior Nasal to Disc, Focal_Nar_SN

N Value Description 2232 0 None 18 1 Questionable 3 2 Present 327 8 Cannot Grade 45 9 No photos taken for the eye

RETF062 Focal Narrowing Inferior Nasal to Disc, Focla_Nar_IN

N Value Description 2244 0 None 15 1 Questionable 6 2 Present 315 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 16 of 21 ______Section 2: Central Agency Files

RETF063 Focal Narrowing Inferior Temporal to Disc, Focal_Nar_IT

N Value Description 2313 0 None 17 1 Questionable 3 2 Present 247 8 Cannot Grade 45 9 No photos taken for the eye

RETF064 Calculated variable for AV nicking quadrants, CALC_AV_NICK_

N Value Description 2004 0 None 296 1 Questionable 139 2 Present in at least one quadrant 141 8 Cannot Grade 45 Missing

RETF065 Arterio-Venous Nicking Superior Temporal to Disk, AV_Nick_ST

N Value Description 2117 0 None 190 1 Questionable 104 2 Present 169 8 Cannot Grade 45 9 No photos taken for the eye

RETF066 Arterio-Venous Nicking Superior Nasal to Disk, AV_Nick_SN

N Value Description 2322 0 None 35 1 Questionable 7 2 Present 216 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 17 of 21 ______Section 2: Central Agency Files

RETF067 Arterio-Venous Nicking Inferior Nasal to Disk, AV_Nick_IN

N Value Description 2337 0 None 25 1 Questionable 4 2 Present 214 8 Cannot Grade 45 9 No photos taken for the eye

RETF068 Arterio-Venous Nicking Inferior Temporal to Disk, AV_Nick_IT

N Value Description 2212 0 None 124 1 Questionable 52 2 Present 192 8 Cannot Grade 45 9 No photos taken for the eye

RETF069 Branch Vein Occlusion, Vasc_BVO

N Value Description 2429 0 None 3 1 Questionable 9 2 Present 139 8 Cannot Grade 45 9 No photos taken for the eye

RETF070 Central Vein Occlusion, Vasc_CVO

N Value Description 2492 0 None 1 3 Present in center circle 87 8 Cannot Grade 45 9 No photos taken for the eye

RETF071 Branch Artery or Central Artery Occlusion, Vasc_BAO_CAO

N Value Description 2504 0 None 1 2 Present 75 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 18 of 21 ______Section 2: Central Agency Files

RETF072 Hollenhorst Plaque, Vasc_Hollenhorst

N Value Description 2381 0 None 4 1 Questionable 5 2 Present 190 8 Cannot Grade 45 9 No photos taken for the eye

RETF073 Peripapillary Atrophy, Oth_Peripap_Atrophy

N Value Description 1711 0 None 242 1 Questionable 574 2 Present 53 8 Cannot Grade 45 9 No photos taken for the eye

RETF074 Macular Hole, Oth_Mac_Hole

N Value Description 2180 0 None 5 1 Questionable 3 2 Present 392 8 Cannot Grade 45 9 No photos taken for the eye

RETF075 Large Cup to Disc Ratio > .7, Oth_Large_C_D_Ratio

N Value Description 2267 0 None 153 1 Questionable 88 2 Present 72 8 Cannot Grade 45 9 No photos taken for the eye

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RETF076 Asteroid Hyalosis, Oth_Asteroid

N Value Description 2532 0 None 2 1 Questionable 20 2 Present 26 8 Cannot Grade 45 9 No photos taken for the eye

RETF077 Choroidal Nevus, Oth_Nevus

N Value Description 2266 0 None 24 1 Questionable 73 2 Present 217 8 Cannot Grade 45 9 No photos taken for the eye

RETF078 Traction from Surface Wrinkling Retinopathy, Oth_SWR_Traction

N Value Description 2114 0 None 9 1 Questionable 38 2 Present 11 3 Present in center circle 408 8 Cannot Grade 45 9 No photos taken for the eye

RETF079 Cellophane Reflex from Surface Wrinkling Retinopathy, Oth_SWR_Cello

N Value Description 1612 0 None 73 1 Questionable 487 2 Present 16 3 Present in center circle 392 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 20 of 21 ______Section 2: Central Agency Files

RETF080 Presumed Ocular Histoplamosis Syndrome, Oth_POHS

N Value Description 2552 0 None 1 2 Present 27 8 Cannot Grade 45 9 No photos taken for the eye

RETF081 Retinal Detachment (not from ARM), Oth_Ret_Detach

N Value Description 2535 0 None 1 2 Present 44 8 Cannot Grade 45 9 No photos taken for the eye

RETF082 Other Treatment (not for ARM or DR), Oth_Rx

N Value Description 2537 0 None 11 2 Present 1 3 Present in center circle 31 8 Cannot Grade 45 9 No photos taken for the eye

RETF083 Other Chorioretinal Abnormalities, Oth_Chorioret_Abnorm

N Value Description 2540 0 None 11 2 Present 29 8 Cannot Grade 45 9 No photos taken for the eye

RETF084 Other issues not previously described, Oth_Other

N Value Description 2480 0 None 4 1 Questionable 75 2 Present 21 8 Cannot Grade 45 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 21 of 21 ______Section 2: Central Agency Files

RETF085 Calculated variable for Pure Geographic Atrophy, CALC_Pure_GA

N Value Description 72 7 2136 0 No definite Geographic Atrophy OR eye is Exudative 18 2 Definite Geographic Atrophy AND eye is not exudative 331 8 Cannot Grade Geographic Atrophy AND is not Exudative 23 9 No photos taken for the eye 45 Missing

RETF086 Calculated variable for Exudative ARM, CALC_Exudative

N Value Description 72 7 2156 0 No Definite Exudative ARM Lesions present 23 2 Any of the following ARM lesions definitely present: PED_RD; Subret_Hem; Subret_Fib_Scar; Rx; 329 8 Cannot Grade any Exudative Lesions 45 Missing

RETF087 Grader comment entered Yes/No, Comment

N Value Description 2625 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 1 of 21 ______Section 2: Central Agency Files

Retinal Final Data - Left Eye: FORM CODE=RETF1 VERSION=1.0 Instructions: File contains the final grading data for the participant's left eye.

Retinal Final Data - Left Eye (RETF1)

Vers Vers

N Value Description 2624 0100

EventName EventName

N Value Description 2624 CSCC

Occurrence Occurrence

N Value Description 2624 1

RETF11 ARIC patient identifier, PatientCode

N Value Description 2624 Present Text suppressed

RETF12 ARIC patient acrostic ID, PatientNameCode

N Value Description 2624 X

RETF13 Left Eye

N Value Description 2624 Range 1 - 1 ( median=1 mean=1.0 std=0.0 )

RETF14 Visit Date, Visit_Date

N Value Description 2571 Range 06JUL11:00:00:00 - 30OCT13:00:00:00 53 Missing

RETF15 ARIC exam phase, Visit_Number

N Value Description 2624 Range 8 - 8 ( median=8 mean=8.0 std=0.0 )

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 2 of 21 ______Section 2: Central Agency Files

RETF16 Site name, Site_Name

N Value Description 2571 Present Text suppressed 53 Missing

RETF17 Photos present, Photos

N Value Description 53 0 No photos 151 1 Not all fields present 2420 2 All fields present

RETF18 Photographer's Last name, Photogropher_Last_Name

N Value Description 2571 Present Text suppressed 53 Missing

RETF19 Date Received, Received_Date

N Value Description 2621 Range 18JUL11:00:00:00 - 31OCT13:00:00:00 3 Missing

RETF110 Date Graded, Graded_Date

N Value Description 2624 Range 19JUL11:00:00:00 - 05NOV13:00:00:00

RETF111 Date of Pathology Report, Pathology_Date

N Value Description 30 Range 19JUL11:00:00:00 - 14AUG13:00:00:00 2594 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 3 of 21 ______Section 2: Central Agency Files

RETF112 Reason for Pathology Notification, Pathology_Reason

N Value Description 2541 0 No pathology reported 12 1 Large C/D ratio plus 2 4 Any macular edema (CSME or ME) 2 5 Branch vein occlusion / Central vein occlusion 6 6 Treatable age-related maculopathy 4 7 Hollenhorst plaque 3 9 Macular hole 1 99 Other 53 999 No photos taken for the eye

RETF113 Calculated variable for Age-related Maculopathy, ARM_Severity

N Value Description 1649 0 None 175 1 Early Stage ARM 49 2 Late Stage ARM 74 7 Eye excluded 624 8 Cannot Grade (NoPhoto) 53 9 No photos taken for this eye

RETF114 Photo Field 1 present, Photo_Field1

N Value Description 43 0 No 2528 2 Yes 53 9 No photos taken for this eye

RETF115 Photo quality assessment for Field 1 focus, Photo_Field1_Focus

N Value Description 1653 0 Good/fair 758 1 Borderline 118 2 Poor 42 8 Cannot Grade (No F1 Photo) 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 4 of 21 ______Section 2: Central Agency Files

RETF116 Photo quality assessment for Field 1 gradability, Photo_Field1_Grad

N Value Description 13 0 Field 1 ungradable 2515 2 Field 1 gradable 43 8 Cannot Grade (No F1 Photo) 53 9 No photos taken for the eye

RETF117 Photo Field 2 present, Photo_Field2

N Value Description 111 0 No 2460 2 Yes 53 9 No photos taken for this eye

RETF118 Photo quality assessment for Field 2 focus, Photo_Field2_Focus

N Value Description 1556 0 Good/fair 741 1 Borderline 154 2 Poor 120 8 Cannot Grade (No F2 Photo) 53 9 No photos taken for the eye

RETF119 Photo quality assessment for Field 2 gradability, Photo_Field2_Grad

N Value Description 25 0 Field 2 ungradable 2435 2 Field 2 gradable 111 8 Cannot Grade (No F2 Photo) 53 9 No photos taken for the eye

RETF120 Photo quality assessment for field definition, Photo_Field_Def

N Value Description 2485 0 No 86 2 Yes 53 9 No photos taken for this eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 5 of 21 ______Section 2: Central Agency Files

RETF121 Photo quality assessment, haze present, Photo_Haze

N Value Description 911 0 No 1660 2 Yes 53 9 No photos taken for this eye

RETF122 Photo quality assessment, dust or dirt present, Photo_Dust_Dirt

N Value Description 2255 0 No 316 2 Yes 53 9 No photos taken for this eye

RETF123 Photo quality assessment, lashes present, Photo_Lashes

N Value Description 2488 0 No 83 2 Yes 53 9 No photos taken for this eye

RETF124 Photo quality assessment, arc present, Photo_Arc

N Value Description 2133 0 No 438 2 Yes 53 9 No photos taken for this eye

RETF125 Photo quality assessment, color balance (images not too red), Photo_Red_Chan

N Value Description 2568 0 No 3 2 Yes 53 9 No photos taken for this eye

RETF126 Photo quality assessment, proper illumination, Photo_Illum

N Value Description 1410 0 No 1161 2 Yes 53 9 No photos taken for this eye

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RETF127 Photo quality assessment, other issues with photo, Photo_Other

N Value Description 2533 0 No 38 2 Yes 53 9 No photos taken for this eye

RETF128 Photo Gradability, Gradability

N Value Description 1490 0 All fields gradable 7 1 Disc ungradable 745 2 Portion of macula ungradable 267 3 Macula is ungradable 4 4 Portion of Disc and Macula Ungradable 49 5 Disc and Macula are ungradable 9 6 All fields ungradable 53 9 No photos taken for the eye

RETF129 Diabetic Retinopathy Level, Diab_Ret_Level

N Value Description 53 9 No photos taken for this eye 1930 10 DR Absent 31 12 Non-diabetic 77 13 Questionable 2 14 HE, SE, IRMA, without Microaneurysms 30 15 Hem only with no Microaneurysms 65 20 Microaneurysms only 34 31 Early Non-Proliferative Diabetic Retinopathy 9 41 Moderate Non-Proliferative Diabetic Retinopathy 2 60 Fibrous Proliferation only 1 61 No retinopathy, with treatment 1 62 MAs only, with treatment 5 63 Early NPDR, with treatment 384 88 Cannot Grade

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 7 of 21 ______Section 2: Central Agency Files

RETF130 Diabetic Retinopathy- Hemmorhages/Micro-aneursyms, DR_HMA

N Value Description 1942 0 None 77 1 Questionable 77 2 Definite - MA's only 52 3 Hem only 50 4 Less than standard #2A 1 5 Greater than or equal to standard #2A 372 8 Cannot Grade 53 9 No photos taken for the eye

RETF131 Diabetic Retinopathy - Hard Exudate, DR_HE

N Value Description 2235 0 None 2 1 Questionable 14 2 Present 320 8 Cannot Grade 53 9 No photos taken for the eye

RETF132 Diabetic Retinopathy - Soft Exudate, DR_SE

N Value Description 2250 0 None 10 1 Questionable 16 2 Present 295 8 Cannot Grade 53 9 No photos taken for the eye

RETF133 Diabetic Retinopathy- Intraretinal Microvascular Abnormalities, DR_IRMA

N Value Description 2184 0 None 10 1 Questionable 8 2 Smaller than standard #8A 1 3 Larger or equal to standard #8A 368 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 8 of 21 ______Section 2: Central Agency Files

RETF134 Diabetic Retinopathy- Venous Beading, DR_VB

N Value Description 2401 0 None 170 8 Cannot Grade 53 9 No photos taken for the eye

RETF135 Diabetic Retinopathy- New Vessels on Disc, DR_NVD

N Value Description 2459 0 None 4 1 Questionable 108 8 Cannot Grade 53 9 No photos taken for the eye

RETF136 Diabetic Retinopathy- New Vessels Elsewhere, DR_NVE

N Value Description 2342 0 None 2 1 Questionable 227 8 Cannot Grade 53 9 No photos taken for the eye

RETF137 Diabetic Retinopthy- Fibrous Proliferation, DR_FP

N Value Description 2430 0 None 1 2 Fibrous Proliferation elsewhere (not on disc) 1 3 Fibrous Proliferation on disc only 139 8 Cannot Grade 53 9 No photos taken for the eye

RETF138 Diabetic Retinopathy- Pre-retinal or Vitreous Hemmorhage, DR_PRH_VH

N Value Description 2447 0 None 2 1 Questionable 122 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 9 of 21 ______Section 2: Central Agency Files

RETF139 Diabetic Retinopathy- Photocoagulation Scar, DR_PC_Scar

N Value Description 2479 0 None 4 1 Questionable scar or incomplete spatter 1 2 Local PC scars exist 18 3 Scatter or PRP treatment 69 8 Cannot Grade 53 9 No photos taken for the eye

RETF140 Diabetic Retinopathy-Focal Treatment, DR_Foc_Rx

N Value Description 2419 0 None 2 1 Questionable 17 2 MAs Rx only 4 4 MAs + Grid Rx 129 8 Cannot Grade 53 9 No photos taken for the eye

RETF141 Macular Edema, Mac_Ed

N Value Description 2171 0 None 4 1 Questionable 2 3 Present, and Clinically Signifigant ME 1 7 Present, but not diabetic 393 8 Cannot Grade 53 9 No photos taken for the eye

RETF142 Macular Edema in center of macula, Mac_Ctr

N Value Description 2175 0 None 1 1 Questionable 2 2 Present, not Clinically Signifigant ME 393 8 Cannot Grade 53 9 No photos taken for the eye

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RETF143 ARM -Reasons for being excluded from grading, ARM_Exclude

N Value Description 2460 0 None 1 1 Trauma 28 2 Laser treatment 1 3 Vessel Occlusion 4 4 Dystrophy 5 5 Myopic Deneration 1 6 Histo / Toxo 2 7 Inflammatory 22 10 RPE Change not caused by ARM 4 12 Unknown Etiology 6 15 Other Reason 37 88 Cannot Grade 53 99 No photos taken for this eye

RETF144 ARM- Drusen > 125 microns, ARM_Dru_125

N Value Description 1665 0 None 40 1 Questionable 212 2 Present 71 3 Present in center circle 74 7 Excluded from ARM 509 8 Cannot Grade 53 9 No photos taken for the eye

RETF145 ARM- Soft Distinct Drusen, ARM_Soft_Dist

N Value Description 1518 0 None 53 1 Questionable 319 2 Present 103 3 Present in center circle 74 7 Excluded from ARM 504 8 Cannot Grade 53 9 No photos taken for the eye

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RETF146 ARM- Soft Indistinct Drusen, ARM_Soft_Indist

N Value Description 1692 0 None 108 1 Questionable 97 2 Present 49 3 Present in center circle 74 7 Excluded from ARM 551 8 Cannot Grade 53 9 No photos taken for the eye

RETF147 ARM- Soft Drusen Area >500 microns, ARM_Soft_Area_500

N Value Description 1821 0 None 132 2 Present 18 3 Present in center circle 74 7 Excluded from ARM 526 8 Cannot Grade 53 9 No photos taken for the eye

RETF148 ARM- Increased Pigment, ARM_Incr_Pigment

N Value Description 1664 0 None 48 1 Questionable 70 2 Present 74 3 Present in center circle 91 7 Pigment Other or Excluded for ARM 624 8 Cannot Grade 53 9 No photos taken for the eye

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RETF149 ARM- Retinal Pigment Epithelium Depigmentation, ARM_RPE_Depig

N Value Description 1716 0 None 55 1 Questionable 43 2 Present 52 3 Present in center circle 74 7 Excluded from ARM 631 8 Cannot Grade 53 9 No photos taken for the eye

RETF150 ARM- Geographic Atrophy, ARM_Geog_Atrophy

N Value Description 2130 0 None 4 1 Questionable 13 2 Present 17 3 Present in center circle 74 7 Excluded from ARM 333 8 Cannot Grade 53 9 No photos taken for the eye

RETF151 ARM- Pigment Epithelial Detachment or Serous Detachment, ARM_PED_RD

N Value Description 2109 0 None 18 1 Questionable 4 2 Present 5 3 Present in center circle 74 7 Excluded from ARM 361 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 13 of 21 ______Section 2: Central Agency Files

RETF152 ARM- Subretinal Hemmorhage, ARM_Subret_Hem

N Value Description 2153 0 None 4 1 Questionable 1 2 Present 3 3 Present in center circle 74 7 Excluded from ARM 336 8 Cannot Grade 53 9 No photos taken for the eye

RETF153 ARM- Subretinal New Vessels, ARM_SRNV

N Value Description 2151 0 None 2 1 Questionable 1 2 Present 1 3 Present in center circle 74 7 Excluded from ARM 342 8 Cannot Grade 53 9 No photos taken for the eye

RETF154 ARM-Subretinal Fibrous Scar, ARM_Subret_Fib_Scar

N Value Description 2146 0 None 6 1 Questionable 4 2 Present 8 3 Present in center circle 74 7 Excluded from ARM 333 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 14 of 21 ______Section 2: Central Agency Files

RETF155 ARM Treatment, ARM_Rx

N Value Description 2143 0 None 1 1 Questionable 19 2 Present 1 3 Present in center circle 74 7 Excluded from ARM 333 8 Cannot Grade 53 9 No photos taken for the eye

RETF156 ARM- Hard Drusen, ARM_Hard_Dru

N Value Description 1186 0 None 86 1 Questionable 540 2 Present 759 8 Cannot Grade 53 9 No photos taken for the eye

RETF157 Atypical ARM, ARM_Atypical

N Value Description 2124 0 No 15 2 Yes 74 7 Excluded from ARM 358 8 Cannot Grade 53 9 No photos taken for the eye

RETF158 ARM Feedback (used in sending participant results only), ARM_Feedback

N Value Description 2031 0 No ARM 59 1 Drusen Only 67 2 Early ARM 49 3 Late ARM 74 7 Excluded for ARM 291 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 15 of 21 ______Section 2: Central Agency Files

RETF159 Calculated variable for focal narrowing quadrants, CALC_Focal_Nar

N Value Description 2301 0 None 56 1 Questionable 15 2 Present in at least one quadrant 199 8 Cannot Grade 53 Missing

RETF160 Focal Narrowing Superior Temporal to Disc, Focal_Nar_ST

N Value Description 2300 0 None 27 1 Questionable 4 2 Present 240 8 Cannot Grade 53 9 No photos taken for the eye

RETF161 Focal Narrowing Superior Nasal to Disc, Focal_Nar_SN

N Value Description 2225 0 None 15 1 Questionable 5 2 Present 326 8 Cannot Grade 53 9 No photos taken for the eye

RETF162 Focal Narrowing Inferior Nasal to Disc, Focla_Nar_IN

N Value Description 2214 0 None 29 1 Questionable 4 2 Present 324 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 16 of 21 ______Section 2: Central Agency Files

RETF163 Focal Narrowing Inferior Temporal to Disc, Focal_Nar_IT

N Value Description 2298 0 None 14 1 Questionable 8 2 Present 251 8 Cannot Grade 53 9 No photos taken for the eye

RETF164 Calculated variable for AV nicking quadrants, CALC_AV_NICK_

N Value Description 1995 0 None 317 1 Questionable 116 2 Present in at least one quadrant 143 8 Cannot Grade 53 Missing

RETF165 Arterio-Venous Nicking Superior Temporal to Disk, AV_Nick_ST

N Value Description 2117 0 None 215 1 Questionable 68 2 Present 171 8 Cannot Grade 53 9 No photos taken for the eye

RETF166 Arterio-Venous Nicking Superior Nasal to Disk, AV_Nick_SN

N Value Description 2296 0 None 46 1 Questionable 13 2 Present 216 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 17 of 21 ______Section 2: Central Agency Files

RETF167 Arterio-Venous Nicking Inferior Nasal to Disk, AV_Nick_IN

N Value Description 2308 0 None 29 1 Questionable 7 2 Present 227 8 Cannot Grade 53 9 No photos taken for the eye

RETF168 Arterio-Venous Nicking Inferior Temporal to Disk, AV_Nick_IT

N Value Description 2228 0 None 103 1 Questionable 59 2 Present 181 8 Cannot Grade 53 9 No photos taken for the eye

RETF169 Branch Vein Occlusion, Vasc_BVO

N Value Description 2418 0 None 5 1 Questionable 6 2 Present 142 8 Cannot Grade 53 9 No photos taken for the eye

RETF170 Central Vein Occlusion, Vasc_CVO

N Value Description 2483 0 None 2 2 Present 86 8 Cannot Grade 53 9 No photos taken for the eye

RETF171 Branch Artery or Central Artery Occlusion, Vasc_BAO_CAO

N Value Description 2492 0 None 1 2 Present 78 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 18 of 21 ______Section 2: Central Agency Files

RETF172 Hollenhorst Plaque, Vasc_Hollenhorst

N Value Description 2359 0 None 6 1 Questionable 5 2 Present 201 8 Cannot Grade 53 9 No photos taken for the eye

RETF173 Peripapillary Atrophy, Oth_Peripap_Atrophy

N Value Description 1729 0 None 242 1 Questionable 546 2 Present 54 8 Cannot Grade 53 9 No photos taken for the eye

RETF174 Macular Hole, Oth_Mac_Hole

N Value Description 2168 0 None 5 1 Questionable 3 2 Present 395 8 Cannot Grade 53 9 No photos taken for the eye

RETF175 Large Cup to Disc Ratio > .7, Oth_Large_C_D_Ratio

N Value Description 2266 0 None 121 1 Questionable 102 2 Present 82 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 19 of 21 ______Section 2: Central Agency Files

RETF176 Asteroid Hyalosis, Oth_Asteroid

N Value Description 2528 0 None 4 1 Questionable 12 2 Present 3 3 Present in center circle 24 8 Cannot Grade 53 9 No photos taken for the eye

RETF177 Choroidal Nevus, Oth_Nevus

N Value Description 2273 0 None 22 1 Questionable 54 2 Present 1 3 Present in center circle 221 8 Cannot Grade 53 9 No photos taken for the eye

RETF178 Traction from Surface Wrinkling Retinopathy, Oth_SWR_Traction

N Value Description 2115 0 None 15 1 Questionable 26 2 Present 8 3 Present in center circle 407 8 Cannot Grade 53 9 No photos taken for the eye

RETF179 Cellophane Reflex from Surface Wrinkling Retinopathy, Oth_SWR_Cello

N Value Description 1649 0 None 64 1 Questionable 460 2 Present 10 3 Present in center circle 388 8 Cannot Grade 53 9 No photos taken for the eye

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 20 of 21 ______Section 2: Central Agency Files

RETF180 Presumed Ocular Histoplamosis Syndrome, Oth_POHS

N Value Description 2540 0 None 1 1 Questionable 1 2 Present 29 8 Cannot Grade 53 9 No photos taken for the eye

RETF181 Retinal Detachment (not from ARM), Oth_Ret_Detach

N Value Description 2527 0 None 1 1 Questionable 43 8 Cannot Grade 53 9 No photos taken for the eye

RETF182 Other Treatment (not for ARM or DR), Oth_Rx

N Value Description 2529 0 None 9 2 Present 33 8 Cannot Grade 53 9 No photos taken for the eye

RETF183 Other Chorioretinal Abnormalities, Oth_Chorioret_Abnorm

N Value Description 2535 0 None 7 2 Present 29 8 Cannot Grade 53 9 No photos taken for the eye

RETF184 Other issues not previously described, Oth_Other

N Value Description 2477 0 None 5 1 Questionable 67 2 Present 22 8 Cannot Grade 53 9 No photos taken for the eye

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RETF185 Calculated variable for Pure Geographic Atrophy, CALC_Pure_GA

N Value Description 73 7 2118 0 No definite Geographic Atrophy OR eye is Exudative 17 2 Definite Geographic Atrophy AND eye is not exudative 332 8 Cannot Grade Geographic Atrophy AND is not Exudative 31 9 No photos taken for the eye 53 Missing

RETF186 Calculated variable for Exudative ARM, CALC_Exudative

N Value Description 73 7 2134 0 No Definite Exudative ARM Lesions present 31 2 Any of the following ARM lesions definitely present: PED_RD; Subret_Hem; Subret_Fib_Scar; Rx; 333 8 Cannot Grade any Exudative Lesions 53 Missing

RETF187 Grader comment entered Yes/No, Comment

N Value Description 2624 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 1 of 4 ______Section 2: Central Agency Files

Retinal Vessel Measurement Data - Right Eye: FORM CODE=RETV0 VERSION=1.0 Instructions: File contains the vessel measurement data from the participant's retinal scan (right eye).

Retinal Vessel Measurement Data - Right Eye (RETV0)

Vers Vers

N Value Description 2584 0100

EventName EventName

N Value Description 2584 CSCC

Occurrence Occurrence

N Value Description 2584 1

RETV01 ARIC patient identifier

N Value Description 2584 Present Text suppressed

RETV02 Right Eye

N Value Description 2552 Range 0 - 0 ( median=0 mean=0.0 std=0.0 ) 32 Missing

RETV03 ARIC exam phase

N Value Description 2584 Range 8 - 8 ( median=8 mean=8.0 std=0.0 )

RETV04 Central Retinal Ateriole Equivalent

N Value Description 2125 Range 93.64658613 - 215.251417 ( median=142.8320746 mean=142.43664965 std=15.48782115 ) 459 Missing

RETV05 Central Retinal Venule Equivalent

N Value Description 2108 Range 124.0524196 - 303.301948 ( median=204.6615734 mean=204.82765462 std=23.93447992 ) 476 Missing

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RETV06 Number of Veins

N Value Description 2334 Range 2 - 12 ( median=7 mean=7.0 std=1.3 ) 250 Missing

RETV07 Number of Arteries

N Value Description 2334 Range 0 - 15 ( median=7 mean=7.3 std=1.5 ) 250 Missing

RETV08 Ungradeable artery

N Value Description 232 0 No 243 1 Yes 2109 Missing

RETV09 Ungradeable vein

N Value Description 233 0 No 222 1 Yes 2129 Missing

RETV010 Photo Field Definition

N Value Description 247 0 No 18 1 Yes 2319 Missing

RETV011 Photo Issue-Illumination

N Value Description 181 0 No 787 1 Yes 1616 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 3 of 4 ______Section 2: Central Agency Files

RETV012 Photo Issue-Artifact

N Value Description 245 0 No 31 1 Yes 2308 Missing

RETV013 Photo Issue-Pathology

N Value Description 246 0 No 14 1 Yes 2324 Missing

RETV014 Photo Issue-Treatment

N Value Description 249 0 No 8 1 Yes 2327 Missing

RETV015 Photo Issue-Other

N Value Description 249 0 No 14 1 Yes 2321 Missing

RETV016 Cannot grade; fewer than 4 vessels, Reject Less Than 4 Veins

N Value Description 249 0 No 31 1 Yes 2304 Missing

RETV017 Cannot grade; fewer than 4 vessels, Reject Less Than 4 Arteries

N Value Description 249 0 No 44 1 Yes 2291 Missing

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RETV018 Cannot Grade Photo Issue-Washed Out

N Value Description 236 0 No 93 1 Yes 2255 Missing

RETV019 Cannot Grade Photo Issue-Focus

N Value Description 226 0 No 174 1 Yes 2184 Missing

RETV020 Cannot Grade Photo Issue-Disk Head Not Visible

N Value Description 249 0 No 9 1 Yes 2326 Missing

RETV021 Cannot Grade; Other

N Value Description 249 0 No 4 1 Yes 2331 Missing

RETV022 Date of Retinal Analysis Grading

N Value Description 2383 Range 27JUL11:00:00:00 - 04NOV13:00:00:00 201 Missing

RETV023 Grader comment

N Value Description 2584 Present Text suppressed

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 1 of 4 ______Section 2: Central Agency Files

Retinal Vessel Measurement Data - Left Eye: FORM CODE=RETV1 VERSION=1.0 Instructions: File contains the vessel measurement data from the participant's retinal scan (left eye).

Retinal Vessel Measurement Data - Left Eye (RETV1)

Vers Vers

N Value Description 2561 0100

EventName EventName

N Value Description 2561 CSCC

Occurrence Occurrence

N Value Description 2561 1

RETV11 ARIC patient identifier

N Value Description 2561 Present Text suppressed

RETV12 Left Eye

N Value Description 2530 Range 1 - 1 ( median=1 mean=1.0 std=0.0 ) 31 Missing

RETV13 ARIC exam phase

N Value Description 2561 Range 8 - 8 ( median=8 mean=8.0 std=0.0 )

RETV14 Central Retinal Ateriole Equivalent

N Value Description 2099 Range 81.50861928 - 235.8946947 ( median=143.3729955 mean=142.92694770 std=15.75567291 ) 462 Missing

RETV15 Central Retinal Venule Equivalent

N Value Description 2095 Range 123.7924866 - 319.8904223 ( median=203.7571099 mean=204.78002788 std=23.92844599 ) 466 Missing

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Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 2 of 4 ______Section 2: Central Agency Files

RETV16 Number of Veins

N Value Description 2314 Range 2 - 12 ( median=7 mean=7.0 std=1.3 ) 247 Missing

RETV17 Number of Arteries

N Value Description 2314 Range 0 - 12 ( median=7 mean=7.2 std=1.5 ) 247 Missing

RETV18 Ungradeable artery

N Value Description 250 0 No 256 1 Yes 2055 Missing

RETV19 Ungradeable vein

N Value Description 255 0 No 215 1 Yes 2091 Missing

RETV110 Photo Field Definition

N Value Description 275 0 No 22 1 Yes 2264 Missing

RETV111 Photo Issue-Illumination

N Value Description 184 0 No 835 1 Yes 1542 Missing

______

Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 3 of 4 ______Section 2: Central Agency Files

RETV112 Photo Issue-Artifact

N Value Description 276 0 No 26 1 Yes 2259 Missing

RETV113 Photo Issue-Pathology

N Value Description 276 0 No 6 1 Yes 2279 Missing

RETV114 Photo Issue-Treatment

N Value Description 277 0 No 4 1 Yes 2280 Missing

RETV115 Photo Issue-Other

N Value Description 277 0 No 8 1 Yes 2276 Missing

RETV116 Cannot grade; fewer than 4 vessels, Reject Less Than 4 Veins

N Value Description 277 0 No 31 1 Yes 2253 Missing

RETV117 Cannot grade; fewer than 4 vessels, Reject Less Than 4 Arteries

N Value Description 276 0 No 40 1 Yes 2245 Missing

______

Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40 ARIC V5 / NCS Code Book II, S.2 Page 4 of 4 ______Section 2: Central Agency Files

RETV118 Cannot Grade Photo Issue-Washed Out

N Value Description 262 0 No 78 1 Yes 2221 Missing

RETV119 Cannot Grade Photo Issue-Focus

N Value Description 256 0 No 154 1 Yes 2151 Missing

RETV120 Cannot Grade Photo Issue-Disk Head Not Visible

N Value Description 275 0 No 8 1 Yes 2278 Missing

RETV121 Cannot Grade; Other

N Value Description 276 0 No 11 1 Yes 2274 Missing

RETV122 Date of Retinal Analysis Grading

N Value Description 2483 Range 27JUL11:00:00:00 - 04NOV13:00:00:00 78 Missing

RETV123 Grader comment

N Value Description 2561 Present Text suppressed

______

Based on data retrieved November 12, 2014 : Job UC5958F8b by KXJ on 28NOV14 11:40