Table S1: Phenotypic Information related to SJIA-PAP subjects

Exposure to IL-1 Pt ID clubbing RadPattern or IL-6 blockade Bx Published SOMAscan cohort A y ST, GGO, consolidation y PAP/ELP 1,2 B y ST, nodules y na no C n GGO -> ST y na 1,2 D y ST, GGO, consolidation y PAP/ELP 1 E y ST, GGO, consolidation y na 1 F y ST, GGO y PAP/ELP 1 G y ST, GGO -> consolidation y na -> PAP/ELP 1 H y ST, GGO, consolidation y Likely PAP/ELP 1 I y ST, GGO y na 1,2 J y ST, GGO, consolidation y PAP/ELP 1

Verification Cohort A y ST, GGO, consolidation y PAP/ELP 1,2 D y ST, GGO, consolidation y PAP/ELP 1 F y ST, GGO y PAP/ELP 1 G y ST, GGO -> consolidation y PAP/ELP 1 K y consolidation# y na na L n ST# y PAP/ELP 2 M y fibrosis, consolidation# y PAP/ELP 2 N y ST# y PAP/ELP 2 O y ST, consolidation# y na 2 P y ST# y na na Q y ST, consolidation# y PAP/ELP 2 R y ST, GGO, consolidation# y PAP/ELP 2 S n ST, GGO# y na 2 T y ST# y na 2 U y ST# y PAP/ELP 2 PAP=Pulmonary Alveolar Proteinosis; ELP=Endogenous Lipoid Pneumonia ST=multi-lobular intra-lobular septal thickening; GGO=Ground Glass Opacities; -> indicates development after last sample #not part of systematic radiologic review in ref (1) below All patients (except B) published in (1) Saper, Chen, et al., Ann Rheum Dis, 2019 and/or (2) Schulert et al., Arth Rheum, 2019 Table S2: Proteins whose concentration significantly altered by the sJIA disease component

Gene Symbol ID Coefficients t P.Value FDR Full gene name Prt/Prt Complex mapped* S100A12 2.251266229 6.032033241 8.58E-08 0.000108996 S100 calcium binding protein A12 MMP3 2.217432084 5.546202576 5.76E-07 0.000243729 matrix metallopeptidase 3 PAPPA 1.175756804 5.570455678 5.25E-07 0.000243729 pappalysin 1 S100A9 1.099559551 5.472243281 7.67E-07 0.000243729 S100 calcium binding protein A9 MCL1 0.762550308 4.978906915 5.00E-06 0.001270632 MCL1, BCL2 family apoptosis regulator MAPK14 0.877587068 4.929042672 6.02E-06 0.001275133 mitogen-activated protein kinase 14 CKM -1.170378828 -4.853666572 7.96E-06 0.001445508 creatine kinase, M-type CNTN2 -0.667496825 -4.710058605 1.35E-05 0.00214414 contactin 2 EDAR -1.10782229 -4.612868542 1.92E-05 0.002442547 ectodysplasin A receptor NAGK 1.364851621 4.635406218 1.77E-05 0.002442547 N-acetylglucosamine kinase APOB -1.426212002 -4.576739369 2.19E-05 0.002484366 apolipoprotein B HAPLN1 -1.190719311 -4.557677813 2.35E-05 0.002484366 hyaluronan and proteoglycan link protein 1 CKB -1.222006538 -4.502845551 2.86E-05 0.002484935 creatine kinase B CKB.CKM, CKB FAP -0.804764545 -4.480367537 3.10E-05 0.002484935 fibroblast activation protein alpha GPI 1.047687369 4.472551881 3.18E-05 0.002484935 glucose-6-phosphate isomerase IL18 3.6475659 4.444409295 3.52E-05 0.002484935 interleukin 18 MMP1 1.347909655 4.459339234 3.34E-05 0.002484935 matrix metallopeptidase 1 GAPDH 2.228423265 4.421293608 3.82E-05 0.002555909 glyceraldehyde-3-phosphate dehydrogenase MAPK3 0.78186304 4.369730076 4.59E-05 0.002914891 mitogen-activated protein kinase 3 SAA1 3.016776649 4.303379627 5.79E-05 0.00350676 serum amyloid A1 GPC3 -0.682791531 -4.21907112 7.78E-05 0.003813042 glypican 3 LILRB2 0.722365392 4.18704467 8.69E-05 0.004063684 leukocyte immunoglobulin like receptor B2 FTH1 1.673096855 4.121412572 0.000109005 0.004618174 ferritin heavy chain 1 FTH1.FTL FUT5 0.68456594 4.056898669 0.000135942 0.005380091 fucosyltransferase 5 CD109 -0.586777073 -3.966380707 0.000184769 0.006347071 CD109 molecule HK2 1.218236915 3.969635951 0.000182752 0.006347071 hexokinase 2 GSK3A 0.64139195 3.952508008 0.000193606 0.006475622 glycogen synthase kinase 3 alpha GSK3A.GSK3B SLITRK5 -0.935087283 -3.919580413 0.000216238 0.006703381 SLIT and NTRK like family member 5 PKM2 1.01871023 3.883884242 0.000243639 0.006765746 NA PPP3CA 0.648722055 3.886448004 0.000241564 0.006765746 protein phosphatase 3 catalytic subunit alpha PPP3CA.PPP3R1 PRTN3 1.157976164 3.772549339 0.000352163 0.00913468 proteinase 3 COLEC12 -0.748316044 -3.758701358 0.000368529 0.00918431 collectin subfamily member 12 CTSV -0.737192857 -3.736622616 0.000396135 0.009499762 cathepsin V BCAN -0.624746995 -3.714762031 0.000425409 0.010012867 brevican FYN -1.086478202 -3.690449924 0.000460391 0.010639219 FYN proto-oncogene, Src family tyrosine kinase ITGA2B -0.805740518 -3.682073075 0.000473068 0.010736956 integrin subunit alpha 2b ITGA2B.ITGB3 IGHA1 0.664989929 3.61280457 0.000591436 0.012528588 immunoglobulin heavy constant alpha 1 IGHA1.IGHA2 LCN2 1.145530501 3.616246758 0.000584941 0.012528588 lipocalin 2 KYNU 0.986816086 3.599836103 0.000616527 0.012846003 kynureninase IL36A -1.723984034 -3.561804217 0.000696085 0.014043241 interleukin 36 alpha FCGR3B 0.995678631 3.467970518 0.000936189 0.017759653 Fc fragment of IgG receptor IIIb CRP 2.015314074 3.462928471 0.000951096 0.017777102 C-reactive protein MRC1 0.633109586 3.456230272 0.000971247 0.017890649 mannose receptor C-type 1 RETN 0.70260533 3.448366893 0.000995419 0.018040681 resistin KLK8 -0.675000668 -3.429183567 0.001056803 0.018180859 kallikrein related peptidase 8 MRC2 -0.676330115 -3.428661029 0.001058524 0.018180859 mannose receptor C type 2 FGR 1.031226964 3.403270748 0.001145424 0.019402124 FGR proto-oncogene, Src family tyrosine kinase MIA -0.608824356 -3.393689676 0.001179936 0.019476614 melanoma inhibitory activity OMD -0.772947597 -3.378591114 0.001236325 0.020145765 osteomodulin DLL4 0.622838128 3.349363268 0.001352793 0.021492495 delta like canonical Notch ligand 4 ARG1 0.937212532 3.200335815 0.002125637 0.030018716 arginase 1 F9 0.694989244 3.185456224 0.002222259 0.031038371 coagulation factor IX ACAN -0.789557187 -3.110973501 0.002770931 0.035937276 aggrecan IL6 0.875184946 3.088483302 0.002960021 0.038001884 interleukin 6 CCL16 0.80302904 3.039429964 0.00341499 0.042861872 C-C motif chemokine ligand 16 F2 -0.586859929 -3.020469738 0.003607689 0.043670219 coagulation factor II, thrombin IMPDH1 1.092833534 3.003950686 0.003783778 0.043719831 inosine monophosphate dehydrogenase 1 CD163 0.60137612 2.993530975 0.003898925 0.044497858 CD163 molecule MST1 -0.89971528 -2.921621891 0.004786733 0.051558793 macrophage stimulating 1 ANXA1 0.770844072 2.831994123 0.006154824 0.06359985 annexin A1 BPI 1.338630343 2.76763689 0.00735032 0.073561072 bactericidal/permeability-increasing protein IL1RL1 0.98512885 2.759642807 0.007512854 0.074600291 interleukin 1 receptor like 1 HNRNPA2B1 0.796750709 2.742829334 0.007865514 0.076900526 heterogeneous nuclear ribonucleoprotein A2/B1 ADRBK1 0.629098886 2.706686303 0.00867551 0.080485937 NA CDON -0.622995579 -2.709389463 0.008612387 0.080485937 cell adhesion associated, oncogene regulated TNFAIP6 0.606792963 2.710062752 0.008596731 0.080485937 TNF alpha induced protein 6 TFF1 0.736084344 2.67195038 0.009525155 0.086474801 trefoil factor 1 XRCC6 0.597138465 2.67226078 0.009517238 0.086474801 X-ray repair cross complementing 6 CA6 -1.039389931 -2.636474725 0.010470638 0.091780554 carbonic anhydrase 6 EPO 0.657346475 2.630858116 0.01062793 0.09189183 erythropoietin CA3 -0.679266429 -2.601498958 0.011485664 0.097975029 carbonic anhydrase 3 HGF 0.60288153 2.590043224 0.011837059 0.09897962 hepatocyte growth factor MMP8 1.064276273 2.448053123 0.017076939 0.130704429 matrix metallopeptidase 8 MMP9 0.664360023 2.448485006 0.017058253 0.130704429 matrix metallopeptidase 9 ICOSLG 0.60206072 2.432021248 0.017783716 0.134542282 inducible T-cell costimulator ligand COL8A1 0.672616053 2.416875883 0.018475385 0.135733565 collagen type VIII alpha 1 chain SFTPD 1.032516415 2.415991846 0.018516493 0.135733565 surfactant protein D MAPK1 0.686684336 2.40106143 0.019223227 0.13756474 mitogen-activated protein kinase 1 PPIF -0.799374275 -2.367748533 0.02088772 0.145072634 peptidylprolyl isomerase F AKR1A1 0.605561556 2.318367131 0.023591732 0.154093001 aldo-keto reductase family 1 member A1 LTA4H -1.444148219 -2.309253013 0.024123478 0.154824019 leukotriene A4 hydrolase PLA2G2A 0.990721527 2.27157691 0.026436103 0.163903839 phospholipase A2 group IIA MDK -0.806953514 -2.222574853 0.029735905 0.174287384 midkine CD177 0.689873471 2.186543509 0.032388365 0.179898302 CD177 molecule PTPN11 -0.606073471 -2.169812105 0.033689052 0.182173461 protein tyrosine phosphatase, non-receptor type 11 HSP90AA1 0.605987126 2.16499627 0.034071805 0.182722633 heat shock protein 90 alpha family class A member 1 HSP90AA1.HSP90AB1

*: If a gene symbol is mapped to multiple annotated Somascan analytes (protein or protein complexes), the information is shown. Table S3: Proteins whose concentration significantly altered by the MAS disease component Gene Symbol ID Coefficients t P.Value FDR full_name Prt/Prt Complex mapped FTH1 3.399631014 8.478480327 4.19E-12 5.32E-09 ferritin heavy chain 1 FTH1.FTL HSPA1A 1.303989558 6.287296851 3.10E-08 9.86E-06 heat shock protein family A (Hsp70) member 1A MAP2K1 0.615474776 6.312923966 2.80E-08 9.86E-06 mitogen-activated protein kinase kinase 1 SERPINA4 -0.937763489 -6.405068942 1.94E-08 9.86E-06 serpin family A member 4 YES1 0.911991643 5.891712499 1.49E-07 3.80E-05 YES proto-oncogene 1, Src family tyrosine kinase ENO1 1.274696374 5.471017697 7.71E-07 0.000139934 enolase 1 MAPK14 1.34176103 5.359046795 1.19E-06 0.000188346 mitogen-activated protein kinase 14 HSP90AA1 1.541717073 5.089897471 3.30E-06 0.000465573 heat shock protein 90 alpha family class A member 1 HSP90AA1.HSP90AB1 AFM -0.811793112 -4.923343068 6.15E-06 0.000723785 afamin HSPA8 1.193320113 4.805976323 9.49E-06 0.000928127 heat shock protein family A (Hsp70) member 8 PLA2G2A 2.537238761 4.812063239 9.28E-06 0.000928127 phospholipase A2 group IIA HSP90AB1 1.067570601 4.780609148 1.04E-05 0.000946137 heat shock protein 90 alpha family class B member 1 HIST1H3A 1.553006523 4.545101983 2.45E-05 0.001633146 histone cluster 1 H3 family member a LBP 0.791793981 4.538426099 2.51E-05 0.001633146 lipopolysaccharide binding protein PRKCZ 0.804760109 4.554154518 2.38E-05 0.001633146 protein kinase C zeta THBS2 1.251949261 4.532292527 2.57E-05 0.001633146 thrombospondin 2 CA6 -1.839730651 -4.434859636 3.64E-05 0.002203595 carbonic anhydrase 6 NAMPT 1.600166221 4.278475234 6.32E-05 0.003493788 nicotinamide phosphoribosyltransferase DCTPP1 1.195168831 4.210757523 8.01E-05 0.004205713 dCTP pyrophosphatase 1 MPO 0.954850612 4.201313817 8.27E-05 0.004205713 myeloperoxidase FCN3 0.822268491 4.159890378 9.55E-05 0.00449439 ficolin 3 NAGK 1.659404418 4.087772132 0.000122335 0.005361643 N-acetylglucosamine kinase MAP2K4 -1.379796553 -4.003671051 0.000162896 0.006678716 mitogen-activated protein kinase kinase 4 GDI2 0.918223052 3.895542819 0.000234342 0.009006606 GDP dissociation inhibitor 2 MCL1 0.798717224 3.873765594 0.000251993 0.009006606 MCL1, BCL2 family apoptosis regulator MMP17 0.595401711 3.865455598 0.000259059 0.009006606 matrix metallopeptidase 17 LDHB 0.707544413 3.84726616 0.000275195 0.009204546 lactate dehydrogenase B STAT3 0.9387298 3.816673705 0.000304529 0.00992451 signal transducer and activator of transcription 3 AKR1A1 1.247129117 3.801542652 0.000320122 0.01017188 aldo-keto reductase family 1 member A1 POR 1.159717431 3.79144723 0.000330948 0.010259396 cytochrome p450 oxidoreductase GPI 1.25843132 3.776058904 0.000348127 0.010330923 glucose-6-phosphate isomerase FGG 0.678108073 3.705127656 0.000438957 0.011870509 fibrinogen gamma chain MDH1 0.880344575 3.714716428 0.000425472 0.011870509 malate dehydrogenase 1 XPNPEP1 1.387740104 3.707461407 0.000435638 0.011870509 X-prolyl aminopeptidase 1 CD27 -0.614582841 -3.638956661 0.000543764 0.014094009 CD27 molecule HGFAC -1.085257764 -3.617229109 0.0005831 0.014531774 HGF activator CAPG 0.827240288 3.59765475 0.000620846 0.014574341 capping actin protein, gelsolin like RBM39 0.781140644 3.57320891 0.000671257 0.014967852 RNA binding motif protein 39 ICOSLG 1.09429432 3.523717385 0.000785479 0.01692109 inducible T-cell costimulator ligand APOM -0.756921528 -3.485757829 0.000885352 0.018447245 apolipoprotein M YWHAB 0.880605704 3.4468683 0.00100009 0.019861167 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta YWHAB, YWHAB.YWHAE.YWHAG.YWHAH.YWHAQ.YWHAZ.SFN CTSV -0.737519067 -3.42738789 0.001062728 0.020465569 cathepsin V PTPN11 1.103376202 3.400491644 0.001155335 0.021621756 protein tyrosine phosphatase, non-receptor type 11 HTRA2 0.690483266 3.313543474 0.00150966 0.025247071 HtrA serine peptidase 2 HRG -0.672050266 -3.304348924 0.001552607 0.025628101 histidine rich glycoprotein PTPN6 1.261684265 3.290160501 0.001621146 0.026081984 protein tyrosine phosphatase, non-receptor type 6 YWHAZ 0.819023932 3.259602278 0.001778554 0.027907926 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta IL1RL1 1.406019984 3.240846423 0.001882171 0.028479036 interleukin 1 receptor like 1 CLEC1B -0.597932304 -3.115655415 0.002733014 0.037592137 C-type lectin domain family 1 member B PRTN3 1.030316413 3.120927359 0.002690899 0.037592137 proteinase 3 ASAH2 -0.792568667 -3.067844064 0.003144084 0.041197229 N-acylsphingosine amidohydrolase 2 MAPK3 0.725255462 3.069047525 0.003133065 0.041197229 mitogen-activated protein kinase 3 MRC1 0.633877747 3.048621504 0.003325063 0.042688439 mannose receptor C-type 1 ADRBK1 0.817521788 3.036283396 0.003446291 0.042943494 NA IGFBP2 1.035643888 3.04031507 0.003406233 0.042943494 insulin like growth factor binding protein 2 FAP -0.599323521 -2.985943578 0.003984812 0.048235197 fibroblast activation protein alpha THPO 0.667916412 2.972485846 0.004141486 0.049658767 thrombopoietin BMP10 0.675041353 2.921310717 0.004790952 0.0538632 bone morphogenetic protein 10 CD36 -0.726836342 -2.907153597 0.004986602 0.0538632 CD36 molecule IL18 3.464802204 2.9031643 0.005043053 0.0538632 interleukin 18 PYY -0.624946946 -2.906048671 0.005002178 0.0538632 peptide YY FCER2 0.713454419 2.822041425 0.006327167 0.060013651 Fc fragment of IgE receptor II PRDX1 0.702448006 2.778690918 0.007130885 0.064738253 peroxiredoxin 1 ITGA1 0.792001293 2.763270889 0.007438684 0.066067905 integrin subunit alpha 1 ITGA1.ITGB1 HAMP 1.610634376 2.740690335 0.007911451 0.067486272 hepcidin antimicrobial peptide VWF 0.877958445 2.713053642 0.008527494 0.071777781 von Willebrand factor STAT1 1.041445649 2.688571327 0.009109554 0.075183399 signal transducer and activator of transcription 1 PDGFB -0.84472126 -2.631373377 0.010613411 0.082367421 platelet derived growth factor subunit B PGAM1 1.379972744 2.63484296 0.010516115 0.082367421 phosphoglycerate mutase 1 RAC1 0.700934055 2.630853706 0.010628054 0.082367421 Rac family small GTPase 1 PDGFA -0.591292855 -2.618094025 0.010993411 0.084682579 platelet derived growth factor subunit A UBE2I 0.643534564 2.584284663 0.012017357 0.088364403 ubiquitin conjugating enzyme E2 I TPI1 0.664833687 2.547220745 0.013238638 0.092963031 triosephosphate isomerase 1 SHC1 0.61211794 2.542241572 0.013410993 0.093163162 SHC adaptor protein 1 TKT 0.591631136 2.513994728 0.014427732 0.097331052 transketolase F2 -0.642474418 -2.496164139 0.015104839 0.0988685 coagulation factor II, thrombin PI3 0.755231593 2.492526607 0.015246441 0.0988685 peptidase inhibitor 3 PRSS2 0.721001898 2.493595267 0.015204716 0.0988685 protease, serine 2 CAT 0.685412674 2.472067566 0.016065372 0.101587501 catalase IGHM -0.641461834 -2.460519006 0.01654491 0.102348016 immunoglobulin heavy constant mu IGHM.IGJ.IGK..IGL. SAA1 2.21597527 2.460357869 0.016551691 0.102348016 serum amyloid A1 CXCL13 0.860900442 2.452770014 0.016873848 0.10302182 C-X-C motif chemokine ligand 13 TNFRSF1B 0.699905341 2.445227046 0.017199668 0.10311688 TNF receptor superfamily member 1B ADSL 0.652828881 2.430864752 0.017835701 0.104949892 adenylosuccinate lyase NTN1 1.029074333 2.416432513 0.018495992 0.108333666 netrin 1 RET -0.596834722 -2.399213415 0.01931236 0.110690068 ret proto-oncogene BAD 0.591212373 2.380230589 0.020249553 0.112953495 BCL2 associated agonist of cell death S100A12 1.127968291 2.378219535 0.02035118 0.112953495 S100 calcium binding protein A12 S100A9 0.651480136 2.371240875 0.020707385 0.113825083 S100 calcium binding protein A9 TPT1 0.684222325 2.366045806 0.020976151 0.114423553 tumor protein, translationally-controlled 1 GNLY 0.734217793 2.351913751 0.021723075 0.116498009 granulysin FCGR3B 0.91875608 2.330275057 0.022912679 0.119352523 Fc fragment of IgG receptor IIIb CDON -0.668255305 -2.265795398 0.026807816 0.133618566 cell adhesion associated, oncogene regulated LEP -0.691993914 -2.206500176 0.030894688 0.144397064 leptin HIST3H2A 1.103189207 2.195070309 0.031742591 0.14657682 histone cluster 3 H2A LAG3 0.588793562 2.181755092 0.032756041 0.149221964 lymphocyte activating 3 SUMO3 0.634822297 2.176025308 0.033200801 0.149755012 small ubiquitin-like modifier 3 HIST2H2BE 0.758951347 2.171555168 0.033551447 0.15068512 histone cluster 2 H2B family member e LGALS9 0.60516485 2.10918635 0.038792385 0.163441503 galectin 9 IL1R1 -1.612387882 -2.097649429 0.039836242 0.166552184 interleukin 1 receptor type 1 MDK 0.902523744 2.082286681 0.041264059 0.170835893 midkine CRP 1.246753165 2.063024243 0.043116812 0.17677893 C-reactive protein PRKACA 0.837879231 2.05864277 0.043548149 0.177402875 protein kinase cAMP-activated catalytic subunit alpha CXCL9 0.973464496 2.052831573 0.044125985 0.177481413 C-X-C motif chemokine ligand 9 LCN2 0.813689672 2.053995424 0.04400973 0.177481413 lipocalin 2 Table S4: Proteins whose concentration significantly altered by the sJIA-PAP disease component Gene Symbol ID Coefficients t P.Value FDR full_name Prt/Prt Complex mapped ICAM5 0.846443494 5.139654079 2.07E-06 0.000916677 intercellular adhesion molecule 5 POR 1.082182934 5.129217848 2.16E-06 0.000916677 cytochrome p450 oxidoreductase MMP7 0.927518201 5.102130708 2.41E-06 0.000916677 matrix metallopeptidase 7 CCL11 0.708451121 4.990188794 3.73E-06 0.000916677 C-C motif chemokine ligand 11 ANG 0.721309076 4.956708219 4.25E-06 0.000916677 angiogenin GDF15 0.775165598 4.951867243 4.33E-06 0.000916677 growth differentiation factor 15 CAPN1 0.62832412 4.908995558 5.11E-06 0.000927715 calpain 1 CAPN1.CAPNS1 LDHB 0.587787775 4.681692829 1.22E-05 0.001936829 lactate dehydrogenase B S100A12 -1.664300731 -4.588267529 1.73E-05 0.002447341 S100 calcium binding protein A12 APOM 0.711000075 4.432038779 3.10E-05 0.003523465 apolipoprotein M REN 0.915497396 4.259051747 5.82E-05 0.005686816 renin FLRT3 0.62081125 4.173446337 7.91E-05 0.007179121 fibronectin leucine rich transmembrane protein 3 FUT5 -0.689397814 -4.00203719 0.000144778 0.012267512 fucosyltransferase 5 CCL15 0.760877528 3.951247772 0.000172724 0.013669992 C-C motif chemokine ligand 15 RET -0.720960447 -3.673599667 0.000443026 0.024481977 ret proto-oncogene HAMP -1.899087025 -3.632496994 0.000507583 0.026880747 hepcidin antimicrobial peptide NAGK 0.828559321 3.586803995 0.00058982 0.029986474 N-acetylglucosamine kinase CCL7 0.927730591 3.541589425 0.00068354 0.033414606 C-C motif chemokine ligand 7 CCDC80 -0.593197029 -3.438295419 0.000953305 0.04060835 coiled-coil domain containing 80 F5 0.606823905 3.436593001 0.000958498 0.04060835 coagulation factor V CCL17 0.971315296 3.276944482 0.001583552 0.062896703 C-C motif chemokine ligand 17 CCL25 0.883134117 3.234396174 0.00180574 0.069253778 C-C motif chemokine ligand 25 KYNU 0.927687027 3.226057059 0.001852579 0.069253778 kynureninase IL18 2.269773632 3.05371015 0.003115718 0.099452085 interleukin 18 MMP1 -0.91980654 -3.016945868 0.003472961 0.107661789 matrix metallopeptidase 1 ADIPOQ 0.607212126 2.930433231 0.004468754 0.126217485 adiponectin, C1Q and collagen domain containing Table S5: Gene Ontology Enrichment for different disease components Comparison set.name original.size filtered.size relevant.protein.size relevant.proteins pval padj LILRB2,MAPK14,F2,FCGR3B,FGR,FTH1,XRCC6,GPI,HSP90AA1,IL6,IMPDH1,ARG1,LCN2,LTA4H,MMP8,MMP9,PKM,MAPK1,PRTN3,RETN,CD1 Active sJIA vs. Healthy control GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY 555 147 25 77,S100A9,S100A12,BPI,TNFAIP6 4.16E-06 0.008897 Active sJIA vs. Healthy control GO_COLLAGEN_METABOLIC_PROCESS 113 33 10 F2,FAP,IL6,ARG1,MMP1,MMP3,MMP8,MMP9,PRTN3,MRC2 3.25E-05 0.023738 LILRB2,MAPK14,FCGR3B,FGR,FTH1,XRCC6,GPI,ANXA1,HSP90AA1,IL6,IL18,IMPDH1,ARG1,LCN2,LTA4H,MDK,MMP8,MMP9,PKM,MAPK1,PR Active sJIA vs. Healthy control GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 720 187 27 TN3,RETN,CD177,S100A9,S100A12,BPI,TNFAIP6 4.01E-05 0.023738 LILRB2,MAPK14,FCGR3B,FGR,FTH1,XRCC6,GPI,HSP90AA1,IL6,IL18,IMPDH1,ARG1,LCN2,LTA4H,MMP8,MMP9,PKM,PLA2G2A,MAPK1,PRTN Active sJIA vs. Healthy control GO_MYELOID_LEUKOCYTE_ACTIVATION 662 188 27 3,RETN,CD177,S100A9,S100A12,BPI,TNFAIP6,IL1RL1 4.44E-05 0.023738 LILRB2,CD109,MAPK14,FCGR3B,FGR,FTH1,XRCC6,GPI,ANXA1,HGF,HSP90AA1,IMPDH1,ITGA2B,ARG1,LCN2,LTA4H,MMP8,MMP9,PKM,MA Active sJIA vs. Healthy control GO_EXOCYTOSIS 914 203 27 PK1,PRTN3,RETN,CD177,S100A9,S100A12,BPI,TNFAIP6 0.000184 0.069897 LILRB2,MAPK14,EPO,F2,FCGR3B,FGR,ICOSLG,FTH1,FYN,XRCC6,GPI,ANXA1,HSP90AA1,IGHA1,IL6,IL18,IMPDH1,ITGA2B,ARG1,LCN2,LTA4 H,MDK,MMP8,MMP9,PKM,PLA2G2A,DLL4,PPP3CA,MAPK1,MAPK3,PRTN3,RETN,CD177,PTPN11,S100A9,S100A12,SAA1,SFTPD,BPI,TNFAIP Active sJIA vs. Healthy control GO_CELL_ACTIVATION 1475 374 41 6,IL1RL1 0.000196 0.069897 Active sJIA vs. Healthy control GO_MONOSACCHARIDE_CATABOLIC_PROCESS 66 16 6 AKR1A1,FUT5,GAPDH,GPI,HK2,PKM 0.000388 0.084411 LILRB2,CRP,MAPK14,EPO,F2,FGR,IL36A,GPC3,APOB,IGHA1,IL6,IL18,ARG1,LCN2,MRC1,PLA2G2A,MAPK1,MAPK3,S100A9,S100A12,SFTPD, Active sJIA vs. Healthy control GO_RESPONSE_TO_BACTERIUM 743 178 24 BPI,CA3,CO LEC12 0.000388 0.084411 Active sJIA vs. Healthy control GO_COLLAGEN_CATABOLIC_PROCESS 47 22 7 FAP,MMP1,MMP3,MMP8,MMP9,PRTN3,MRC2 0.000394 0.084411 Active sJIA vs. Healthy control GO_MACROPHAGE_CHEMOTAXIS 42 22 7 MAPK14,MDK,MST1,MAPK1,MAPK3,SAA1,SFTPD 0.000394 0.084411 LILRB2,CRP,MAPK14,F2,FCGR3B,FGR,FTH1,XRCC6,GPI,HSP90AA1,IGHA1,IL6,IL18,IMPDH1,ARG1,LCN2,LTA4H,MMP8,MMP9,PKM,MAPK1,P Active sJIA vs. Healthy control GO_LEUKOCYTE_MEDIATED_IMMUNITY 885 225 28 RTN3,RETN,CD177,S100A9,S100A12,BPI,TNFAIP6 0.000445 0.086609 Active sJIA vs. Healthy control GO_ORGANIC_ACID_METABOLIC_PROCESS 1183 118 18 AKR1A1,CKB,CKM,MAPK14,ACAN,GAPDH,GPI,ANXA1,HGF,HK2,ARG1,LTA4H,OMD,PKM,NAGK,MAPK3,BCAN,KYNU 0.000549 0.097866 LILRB2,CD109,MAPK14,GRK2,FCGR3B,FGR,FTH1,XRCC6,GAPDH,GPI,ANXA1,HGF,HK2,HSP90AA1,IL6,IMPDH1,ITGA2B,ARG1,LCN2,LTA4H, Active sJIA vs. Healthy control GO_SECRETION 1618 331 36 MMP8,MMP9,PKM,PLA2G2A,PPP3CA,MAPK1,PRTN3,RETN,CD177,PTPN11,S100A9,S100A12,SAA1,BPI,TNFAIP6,IL1RL1 0.000789 0.12557 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS 360 83 14 PPIF,EPO,FYN,XRCC6,ANXA1,HGF,IL6,ARG1,LCN2,MCL1,MMP3,MMP9,MAPK1,MAPK3 0.000895 0.12557 Active sJIA vs. Healthy control GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS 672 74 13 AKR1A1,CKB,CKM,MAPK14,GAPDH,GPI,ANXA1,HK2,LTA4H,PKM,MAPK3,BCAN,KYNU 0.000934 0.12557 Active sJIA vs. Healthy control GO_MACROPHAGE_MIGRATION 57 25 7 MAPK14,MDK,MST1,MAPK1,MAPK3,SAA1,SFTPD 0.000939 0.12557 Active sJIA vs. Healthy control GO_ANTIMICROBIAL_HUMORAL_RESPONSE 137 49 10 F2,GAPDH,IGHA1,LCN2,PLA2G2A,PRTN3,S100A9,S100A12,SFTPD,BPI 0.001158 0.137721 Active sJIA vs. Healthy control GO_SMALL_MOLECULE_CATABOLIC_PROCESS 452 49 10 AKR1A1,FUT5,GAPDH,GPI,GSK3A,HK2,ARG1,PKM,NAGK,KYNU 0.001158 0.137721 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES 170 52 10 PPIF,ANXA1,HGF,IL6,ARG1,LCN2,MMP3,MMP9,MAPK1,MAPK3 0.001879 0.211655 Active sJIA vs. Healthy control GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS 30 15 5 MAPK14,MDK,MST1,MAPK1,MAPK3 0.002281 0.232487 Active sJIA vs. Healthy control GO_HEXOSE_CATABOLIC_PROCESS 56 15 5 FUT5,GAPDH,GPI,HK2,PKM 0.002281 0.232487 LILRB2,CRP,MAPK14,F2,FCGR3B,FGR,FTH1,FYN,XRCC6,GPI,ANXA1,HSP90AA1,IGHA1,IL6,IL18,IMPDH1,ARG1,LCN2,LTA4H,MDK,MMP8,M Active sJIA vs. Healthy control GO_IMMUNE_EFFECTOR_PROCESS 1292 300 32 MP9,PKM,MAPK1,MAPK3,PRTN3,RETN,CD177,S100A9,S100A12,BPI,TNFAIP6 0.002651 0.246759 Active sJIA vs. Healthy control GO_HYPEROSMOTIC_RESPONSE 28 5 3 EPO,ICOSLG,XRCC6 0.002767 0.246759 Active sJIA vs. Healthy control GO_RESPONSE_TO_DOPAMINE 91 5 3 GSK3A,MAPK1,MAPK3 0.002767 0.246759 Active sJIA vs. Healthy control GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING 81 10 4 HNRNPA2B1,HSP90AA1,MAPK1,MAPK3 0.003079 0.249041 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY 36 10 4 HNRNPA2B1,HSP90AA1,MAPK1,MAPK3 0.003079 0.249041 Active sJIA vs. Healthy control GO_TELOMERE_ORGANIZATION 174 16 5 XRCC6,HNRNPA2B1,HSP90AA1,MAPK1,MAPK3 0.003142 0.249041 Active sJIA vs. Healthy control GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS 1827 138 18 AKR1A1,CKB,CKM,ACAN,EPO,FUT5,GAPDH,GPC3,APOB,IL6,IMPDH1,ARG1,OMD,PKM,MAPK1,MAPK3,BCAN,KYNU 0.003649 0.278919 Active sJIA vs. Healthy control GO_CARBOHYDRATE_CATABOLIC_PROCESS 200 32 7 AKR1A1,FUT5,GAPDH,GPI,GSK3A,HK2,PKM 0.004435 0.311253 Active sJIA vs. Healthy control GO_GLYCOLYTIC_PROCESS_THROUGH_FRUCTOSE_6_PHOSPHATE 29 11 4 GAPDH,GPI,HK2,PKM 0.004588 0.311253 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION 69 25 6 FGR,GAPDH,IL6,MMP8,SAA1,IL1RL1 0.0052 0.311253 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE 51 6 3 HNRNPA2B1,MAPK1,MAPK3 0.005263 0.311253 Active sJIA vs. Healthy control GO_BERGMANN_GLIAL_CELL_DIFFERENTIATION 8 6 3 MAPK1,MAPK3,PTPN11 0.005263 0.311253 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING37 6 3 HNRNPA2B1,MAPK1,MAPK3 0.005263 0.311253 Active sJIA vs. Healthy control GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES 235 69 11 PPIF,FYN,ANXA1,HGF,IL6,ARG1,LCN2,MMP3,MMP9,MAPK1,MAPK3 0.005298 0.311253 Active sJIA vs. Healthy control GO_GLUCOSE_IMPORT 75 18 5 MAPK14,GPC3,GSK3A,HK2,PTPN11 0.005527 0.311253 Active sJIA vs. Healthy control GO_REGULATION_OF_GLUCOSE_IMPORT 61 18 5 MAPK14,GPC3,GSK3A,HK2,PTPN11 0.005527 0.311253 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS 69 18 5 HGF,HNRNPA2B1,HSP90AA1,MAPK1,MAPK3 0.005527 0.311253 Active sJIA vs. Healthy control GO_RESPONSE_TO_INORGANIC_SUBSTANCE 568 111 15 PPIF,FYN,GSK3A,ANXA1,HGF,APOB,IL6,ARG1,LCN2,MMP3,MMP9,PPP3CA,MAPK1,MAPK3,TFF1 0.005865 0.315603 Active sJIA vs. Healthy control GO_ASTROCYTE_DIFFERENTIATION 83 34 7 F2,IL6,MAPK1,MAPK3,PTPN11,S100A9,CNTN2 0.006336 0.315603 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE 100 26 6 PPIF,ANXA1,HGF,IL6,ARG1,LCN2 0.006395 0.315603 Active sJIA vs. Healthy control GO_ENDOCYTOSIS 668 123 16 GRK2,GPC3,HSP90AA1,APOB,IGHA1,MRC1,PPP3CA,MAPK1,MAPK3,CD177,SAA1,SFTPD,CNTN2,COLEC12,CD163,MRC2 0.006465 0.315603 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS 19 12 4 MAPK14,MDK,MAPK1,MAPK3 0.006528 0.315603 Active sJIA vs. Healthy control GO_REGULATION_OF_TELOMERASE_ACTIVITY 48 12 4 HNRNPA2B1,HSP90AA1,MAPK1,MAPK3 0.006528 0.315603 Active sJIA vs. Healthy control GO_DEFENSE_RESPONSE_TO_BACTERIUM 341 81 12 CRP,F2,FGR,IGHA1,IL6,LCN2,PLA2G2A,S100A9,S100A12,SFTPD,BPI,COLEC12 0.006637 0.315603 Active sJIA vs. Healthy control GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT 1042 160 19 CKB,HAPLN1,ACAN,F2,FYN,XRCC6,SLITRK5,HSP90AA1,IL6,MDK,CDON,DLL4,PPP3CA,MAPK1,MAPK3,PTPN11,S100A9,BCAN,CNTN2 0.008182 0.349051 Active sJIA vs. Healthy control GO_MONOSACCHARIDE_METABOLIC_PROCESS 296 54 9 AKR1A1,MAPK14,FUT5,GAPDH,GPI,GSK3A,HK2,MST1,PKM 0.008681 0.349051 Active sJIA vs. Healthy control GO_RESPONSE_TO_DSRNA 53 7 3 MAPK1,MAPK3,COLEC12 0.008758 0.349051 Active sJIA vs. Healthy control GO_SKELETAL_MUSCLE_TISSUE_REGENERATION 40 7 3 ANXA1,PKM,PPP3CA 0.008758 0.349051 Active sJIA vs. Healthy control GO_NEUTROPHIL_EXTRAVASATION 14 7 3 MDK,PRTN3,CD177 0.008758 0.349051 Active sJIA vs. Healthy control GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING61 7 3 HNRNPA2B1,MAPK1,MAPK3 0.008758 0.349051 LILRB2,CRP,MAPK14,EPO,F2,FAP,FGR,FYN,XRCC6,GAPDH,IL36A,GPC3,ANXA1,APOB,IGHA1,IL6,IL18,ARG1,LCN2,MRC1,PLA2G2A,MAPK1, Active sJIA vs. Healthy control GO_RESPONSE_TO_BIOTIC_STIMULUS 1615 362 35 MAPK3,PRTN3,CD177,PTPN11,S100A9,S100A12,SAA1,CCL16,SFTPD,BPI,CA3,COLEC12,KYNU 0.008911 0.349051 Active sJIA vs. Healthy control GO_GLUCOSE_CATABOLIC_PROCESS 36 13 4 GAPDH,GPI,HK2,PKM 0.008945 0.349051 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_TRANSLATION 136 13 4 IL6,PKM,MAPK1,MAPK3 0.008945 0.349051 Active sJIA vs. Healthy control GO_REGULATION_OF_MACROPHAGE_MIGRATION 44 20 5 MAPK14,MDK,MST1,MAPK1,MAPK3 0.008971 0.349051 Active sJIA vs. Healthy control GO_ACUTE_PHASE_RESPONSE 47 28 6 CRP,EPO,F2,IL6,SAA1,CD163 0.009368 0.353469 LILRB2,CRP,MAPK14,F2,FGR,ICOSLG,XRCC6,GAPDH,IL36A,ANXA1,HGF,IL6,IL18,ARG1,MDK,MMP8,PTPN11,S100A9,S100A12,SAA1,SFTPD, Active sJIA vs. Healthy control GO_CYTOKINE_PRODUCTION 880 210 23 BPI,IL1RL1 0.00956 0.353469 Active sJIA vs. Healthy control GO_REGULATION_OF_INFLAMMATORY_RESPONSE 425 128 16 MAPK14,F2,ANXA1,HGF,IL6,IL18,MDK,MMP3,MMP8,MMP9,PLA2G2A,S100A9,S100A12,SAA1,TNFAIP6,IL1RL1 0.00958 0.353469 MAPK14,F2,FGR,FYN,XRCC6,ANXA1,HGF,IL6,IL18,ARG1,MDK,MMP3,MMP8,MMP9,PLA2G2A,MAPK3,PTPN11,S100A9,S100A12,SAA1,TNF Active sJIA vs. Healthy control GO_REGULATION_OF_DEFENSE_RESPONSE 747 199 22 AIP6,IL1RL1 0.010229 0.360486 MAPK14,F2,FYN,ANXA1,APOB,IGHA1,IL6,ITGA2B,MDK,MMP1,MST1,MAPK1,MAPK3,PRTN3,CD177,PTPN11,S100A9,S100A12,SAA1,CCL16 Active sJIA vs. Healthy control GO_LEUKOCYTE_MIGRATION 514 187 21 ,SFTPD 0.010247 0.360486 Active sJIA vs. Healthy control GO_PLATELET_ACTIVATION 158 46 8 F2,FYN,IL6,ITGA2B,MAPK1,MAPK3,PTPN11,SAA1 0.010276 0.360486 Active sJIA vs. Healthy control GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS 673 56 9 AKR1A1,ACAN,FUT5,GPC3,IMPDH1,OMD,PKM,NAGK,BCAN 0.01104 0.377749 Active sJIA vs. Healthy control GO_ENDOCRINE_SYSTEM_DEVELOPMENT 125 29 6 GSK3A,ANXA1,IL6,MDK,MAPK1,MAPK3 0.011177 0.377749 Active sJIA vs. Healthy control GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS 1126 119 15 AKR1A1,ACAN,FUT5,GAPDH,GPC3,GPI,GSK3A,HGF,HK2,IMPDH1,OMD,PKM,NAGK,BCAN,KYNU 0.011297 0.377749 Active sJIA vs. Healthy control GO_NADH_METABOLIC_PROCESS 41 14 4 GAPDH,GPI,HK2,PKM 0.01188 0.391121 Active sJIA vs. Healthy control GO_BODY_MORPHOGENESIS 49 8 3 GPC3,CDON,PTPN11 0.013329 0.411747 Active sJIA vs. Healthy control GO_MYELOID_CELL_APOPTOTIC_PROCESS 33 8 3 EPO,ANXA1,IL6 0.013329 0.411747 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_NEUROINFLAMMATORY_RESPONSE 18 8 3 IL6,IL18,MMP8 0.013329 0.411747 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 222 78 11 LILRB2,MAPK14,IL36A,IL6,IL18,ARG1,LCN2,MRC1,MAPK1,MAPK3,BPI 0.013511 0.411747 Active sJIA vs. Healthy control GO_REGULATION_OF_NEUROINFLAMMATORY_RESPONSE 43 22 5 IL6,IL18,MMP3,MMP8,MMP9 0.013672 0.411747 Active sJIA vs. Healthy control GO_EXTRACELLULAR_MATRIX_DISASSEMBLY 82 39 7 CTSV,FAP,IL6,MMP1,MMP3,MMP8,MMP9 0.013695 0.411747 Active sJIA vs. Healthy control GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS200 58 9 CRP,MAPK14,F2,FYN,HK2,HSP90AA1,MMP3,MMP8,CD177 0.013853 0.411747 Active sJIA vs. Healthy control GO_MYELOID_LEUKOCYTE_MIGRATION 221 111 14 MAPK14,ANXA1,IL6,MDK,MST1,MAPK1,MAPK3,PRTN3,CD177,S100A9,S100A12,SAA1,CCL16,SFTPD 0.014347 0.415532 Active sJIA vs. Healthy control GO_GRANULOCYTE_MIGRATION 149 79 11 MAPK14,ANXA1,MDK,MAPK1,MAPK3,PRTN3,CD177,S100A9,S100A12,SAA1,CCL16 0.014825 0.415532 Active sJIA vs. Healthy control GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION32 15 4 CRP,APOB,IL18,PLA2G2A 0.01537 0.415532 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_MACROPHAGE_MIGRATION 26 15 4 MAPK14,MDK,MAPK1,MAPK3 0.01537 0.415532 Active sJIA vs. Healthy control GO_RESPONSE_TO_OXIDATIVE_STRESS 458 101 13 PPIF,FYN,ANXA1,HGF,IL6,ARG1,LCN2,MCL1,MMP3,MMP9,MAPK1,MAPK3,CA3 0.015549 0.415532 PPIF,LILRB2,AKR1A1,MAPK14,GRK2,FYN,IL36A,GSK3A,ANXA1,HGF,APOB,IL6,IL18,ARG1,LCN2,MMP3,MMP9,MRC1,PKM,PPP3CA,MAPK1,M Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND 1220 244 25 APK3,PTPN11,BPI,COLEC12 0.015873 0.415532 Active sJIA vs. Healthy control GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS 109 23 5 HGF,HNRNPA2B1,HSP90AA1,MAPK1,MAPK3 0.01655 0.415532 Active sJIA vs. Healthy control GO_GLUCOSE_METABOLIC_PROCESS 214 50 8 AKR1A1,MAPK14,GAPDH,GPI,GSK3A,HK2,MST1,PKM 0.016875 0.415532 Active sJIA vs. Healthy control GO_CARBOHYDRATE_METABOLIC_PROCESS 630 81 11 AKR1A1,MAPK14,FUT5,GAPDH,GPI,GSK3A,HK2,MST1,PKM,NAGK,TFF1 0.017743 0.415532 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS 246 81 11 LILRB2,MAPK14,IL36A,IL6,IL18,ARG1,LCN2,MRC1,MAPK1,MAPK3,BPI 0.017743 0.415532 Active sJIA vs. Healthy control GO_RESPONSE_TO_HYDROGEN_PEROXIDE 146 41 7 PPIF,FYN,ANXA1,HGF,IL6,ARG1,LCN2 0.017903 0.415532 Active sJIA vs. Healthy control GO_CYTOKINE_SECRETION 131 41 7 FGR,GAPDH,IL6,MMP8,S100A12,SAA1,IL1RL1 0.017903 0.415532 Active sJIA vs. Healthy control GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT 144 32 6 ANXA1,HGF,IL6,ARG1,MDK,PKM 0.018072 0.415532 Active sJIA vs. Healthy control GO_RECEPTOR_MEDIATED_ENDOCYTOSIS 327 71 10 GRK2,HSP90AA1,APOB,IGHA1,MRC1,SAA1,SFTPD,CNTN2,COLEC12,CD163 0.018568 0.415532 Active sJIA vs. Healthy control GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT 577 71 10 PPIF,MAPK14,EPO,F2,FYN,GPC3,GSK3A,HK2,MMP9,PTPN11 0.018568 0.415532 Active sJIA vs. Healthy control GO_REGULATION_OF_OSSIFICATION 210 51 8 MAPK14,HGF,IL6,MDK,OMD,MAPK1,MAPK3,PTPN11 0.018918 0.415532 Active sJIA vs. Healthy control GO_INTERLEUKIN_6_PRODUCTION 170 51 8 LILRB2,IL36A,HGF,IL6,IL18,MMP8,PTPN11,BPI 0.018918 0.415532 Active sJIA vs. Healthy control GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS 71 9 3 HSP90AA1,MAPK1,MAPK3 0.019019 0.415532 Active sJIA vs. Healthy control GO_ENDOCRINE_PANCREAS_DEVELOPMENT 45 9 3 GSK3A,ANXA1,IL6 0.019019 0.415532 Active sJIA vs. Healthy control GO_REGULATION_OF_TELOMERE_MAINTENANCE 80 9 3 HNRNPA2B1,MAPK1,MAPK3 0.019019 0.415532 Active sJIA vs. Healthy control GO_DNA_GEOMETRIC_CHANGE 116 9 3 XRCC6,ANXA1,HNRNPA2B1 0.019019 0.415532 Active sJIA vs. Healthy control GO_CELLULAR_COMPONENT_MAINTENANCE 61 9 3 FYN,PRTN3,CD177 0.019019 0.415532 Active sJIA vs. Healthy control GO_FACE_DEVELOPMENT 48 9 3 MAPK1,MAPK3,PTPN11 0.019019 0.415532 Active sJIA vs. Healthy control GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 356 115 14 LILRB2,MAPK14,EPO,IL36A,APOB,IL6,IL18,ARG1,LCN2,MRC1,MAPK1,MAPK3,S100A9,BPI 0.019313 0.415532 Active sJIA vs. Healthy control GO_REGULATION_OF_BODY_FLUID_LEVELS 513 115 14 F2,F9,FAP,FYN,GPI,HK2,IL6,ITGA2B,MAPK1,MAPK3,PRTN3,CD177,PTPN11,SAA1 0.019313 0.415532 Active sJIA vs. Healthy control GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE 31 16 4 ANXA1,IL6,IL18,ARG1 0.019446 0.415532 Active sJIA vs. Healthy control GO_NAD_METABOLIC_PROCESS 50 16 4 GAPDH,GPI,HK2,PKM 0.019446 0.415532 Active sJIA vs. Healthy control GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS 192 16 4 AKR1A1,ACAN,OMD,BCAN 0.019446 0.415532 Active sJIA vs. Healthy control GO_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT 79 24 5 MAPK14,GPC3,GSK3A,HK2,PTPN11 0.019806 0.415532 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS167 24 5 GSK3A,IL6,PKM,MAPK1,MAPK3 0.019806 0.415532 Active sJIA vs. Healthy control GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS 368 33 6 AKR1A1,ANXA1,LTA4H,PKM,BCAN,KYNU 0.020905 0.43434 Active sJIA vs. Healthy control GO_COAGULATION 349 95 12 F2,F9,FAP,FYN,IL6,ITGA2B,MAPK1,MAPK3,PRTN3,CD177,PTPN11,SAA1 0.023016 0.457186 Active sJIA vs. Healthy control GO_CARBOHYDRATE_TRANSPORT 151 25 5 MAPK14,GPC3,GSK3A,HK2,PTPN11 0.023457 0.457186 Active sJIA vs. Healthy control GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY 59 25 5 MAPK14,IL18,MAPK1,MAPK3,BPI 0.023457 0.457186 Active sJIA vs. Healthy control GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT 118 25 5 MAPK14,GPC3,GSK3A,HK2,PTPN11 0.023457 0.457186 Active sJIA vs. Healthy control GO_ACTIVATED_T_CELL_PROLIFERATION 46 25 5 EPO,ICOSLG,FYN,IL18,ARG1 0.023457 0.457186 Active sJIA vs. Healthy control GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING 127 53 8 EPO,F2,FGR,FYN,HGF,IL18,MAPK1,MAPK3 0.023531 0.457186 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS 200 34 6 HGF,HNRNPA2B1,HSP90AA1,IL6,MAPK1,MAPK3 0.024027 0.457186 Active sJIA vs. Healthy control GO_FOAM_CELL_DIFFERENTIATION 38 17 4 CRP,APOB,IL18,PLA2G2A 0.024133 0.457186 Active sJIA vs. Healthy control GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH 77 17 4 FYN,HGF,MCL1,MMP3 0.024133 0.457186 Active sJIA vs. Healthy control GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS 288 74 10 CRP,MAPK14,F2,FYN,HK2,HSP90AA1,MMP3,MMP8,CD177,SFTPD 0.024356 0.457186 Active sJIA vs. Healthy control GO_HUMORAL_IMMUNE_RESPONSE 370 107 13 CRP,F2,GAPDH,GPI,IGHA1,IL6,LCN2,PLA2G2A,PRTN3,S100A9,S100A12,SFTPD,BPI 0.02447 0.457186 Active sJIA vs. Healthy control GO_PHAGOCYTOSIS 375 85 11 CRP,FGR,FYN,ANXA1,HSP90AA1,IGHA1,MAPK1,MAPK3,PRTN3,SFTPD,COLEC12 0.024847 0.457186 EDAR,KLK8,CD109,MAPK14,EPO,F2,FAP,FGR,FYN,XRCC6,ANXA1,HGF,HSP90AA1,IL6,IL18,ARG1,MCL1,MDK,MMP3,MMP8,MMP9,PLA2G2 Active sJIA vs. Healthy control GO_REGULATION_OF_RESPONSE_TO_STRESS 1538 332 31 A,PPP3CA,MAPK1,MAPK3,PTPN11,S100A9,S100A12,SAA1,TNFAIP6,IL1RL1 0.025262 0.457186 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY 88 10 3 PPIF,EPO,MMP9 0.02585 0.457186 Active sJIA vs. Healthy control GO_COLLAGEN_BIOSYNTHETIC_PROCESS 53 10 3 F2,IL6,ARG1 0.02585 0.457186 Active sJIA vs. Healthy control GO_SULFUR_COMPOUND_CATABOLIC_PROCESS 56 10 3 ACAN,OMD,BCAN 0.02585 0.457186 Active sJIA vs. Healthy control GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION 31 10 3 F2,IL6,CNTN2 0.02585 0.457186 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_CADMIUM_ION 38 10 3 MMP9,MAPK1,MAPK3 0.02585 0.457186 Active sJIA vs. Healthy control GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS 590 55 8 AKR1A1,CKB,CKM,IMPDH1,PKM,PLA2G2A,MAPK1,KYNU 0.028889 0.504161 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_SECRETION 372 87 11 GRK2,FGR,GAPDH,GPI,IL6,MMP8,RETN,CD177,PTPN11,SAA1,IL1RL1 0.029097 0.504161 Active sJIA vs. Healthy control GO_TYPE_2_IMMUNE_RESPONSE 39 18 4 ANXA1,IL6,IL18,ARG1 0.029449 0.504161 Active sJIA vs. Healthy control GO_DEFENSE_RESPONSE_TO_FUNGUS 41 18 4 GAPDH,ARG1,S100A9,S100A12 0.029449 0.504161 Active sJIA vs. Healthy control GO_REGULATION_OF_CELL_ACTIVATION 643 194 20 LILRB2,EPO,F2,FGR,ICOSLG,FYN,XRCC6,ANXA1,IGHA1,IL6,IL18,ARG1,MDK,MMP8,PLA2G2A,CD177,PTPN11,SFTPD,BPI,IL1RL1 0.030318 0.511769 LILRB2,CRP,MAPK14,EPO,F2,FGR,ICOSLG,FYN,XRCC6,GAPDH,IL36A,ANXA1,HGF,IGHA1,IL6,IL18,ARG1,LCN2,MDK,MMP3,MMP8,MMP9,M Active sJIA vs. Healthy control GO_DEFENSE_RESPONSE 1814 432 38 RC1,PLA2G2A,MAPK3,CD177,PTPN11,S100A9,S100A12,SAA1,CCL16,SFTPD,BPI,TNFAIP6,COLEC12,KYNU,IL1RL1,CD163 0.030371 0.511769 Active sJIA vs. Healthy control GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS 194 36 6 ACAN,GPC3,GSK3A,OMD,NAGK,BCAN 0.03118 0.521298 Active sJIA vs. Healthy control GO_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY 144 27 5 FGR,FYN,HSP90AA1,MAPK1,MAPK3 0.032006 0.52687 Active sJIA vs. Healthy control GO_SULFUR_COMPOUND_METABOLIC_PROCESS 371 27 5 AKR1A1,ACAN,OMD,BCAN,KYNU 0.032006 0.52687 Active sJIA vs. Healthy control GO_RESPONSE_TO_CORTICOSTEROID 164 46 7 CTSV,EPO,ANXA1,IL6,ARG1,MDK,PAPPA 0.032265 0.527084 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY34 11 3 FGR,ARG1,CD177 0.033823 0.528336 Active sJIA vs. Healthy control GO_REGULATION_OF_LIPID_STORAGE 52 11 3 CRP,APOB,IL6 0.033823 0.528336 Active sJIA vs. Healthy control GO_ENDODERMAL_CELL_DIFFERENTIATION 46 11 3 COL8A1,MMP8,MMP9 0.033823 0.528336 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY28 11 3 F2,GSK3A,CNTN2 0.033823 0.528336 Active sJIA vs. Healthy control GO_DECIDUALIZATION 25 11 3 CTSV,MAPK1,MAPK3 0.033823 0.528336 Active sJIA vs. Healthy control GO_RESPONSE_TO_CATECHOLAMINE 110 11 3 GSK3A,MAPK1,MAPK3 0.033823 0.528336 Active sJIA vs. Healthy control GO_MAINTENANCE_OF_LOCATION 324 57 8 CRP,F2,FTH1,HK2,APOB,IL6,LCN2,S100A9 0.035044 0.54241 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE 220 37 6 PPIF,GSK3A,MMP3,MMP9,MAPK1,MAPK3 0.035231 0.54241 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION 414 136 15 LILRB2,EPO,FGR,ICOSLG,FYN,XRCC6,ANXA1,IGHA1,IL6,IL18,MDK,MMP8,CD177,PTPN11,IL1RL1 0.035569 0.543697 Active sJIA vs. Healthy control GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS620 68 9 GAPDH,GPI,GSK3A,HK2,IMPDH1,PKM,NAGK,MAPK1,KYNU 0.036398 0.546693 PPIF,LILRB2,MAPK14,GRK2,EPO,F2,FGR,FYN,GAPDH,GPC3,GPI,GSK3A,ANXA1,HK2,IL6,ARG1,MMP8,MMP9,PPP3CA,MAPK1,MAPK3,PRTN3, Active sJIA vs. Healthy control GO_REGULATION_OF_TRANSPORT 1856 301 28 RETN,CD177,PTPN11,SAA1,SFTPD,IL1RL1 0.036475 0.546693 PPIF,LILRB2,AKR1A1,MAPK14,CTSV,GRK2,EPO,FYN,IL36A,GSK3A,ANXA1,HGF,APOB,IL6,IL18,ARG1,LCN2,MMP3,MMP9,MRC1,PKM,PPP3C Active sJIA vs. Healthy control GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND 1714 342 31 A,MAPK1,MAPK3,RETN,PTPN11,S100A9,BPI,TFF1,CA3,COLEC12 0.037804 0.546693 Active sJIA vs. Healthy control GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING 154 58 8 EPO,F2,FGR,FYN,HGF,IL18,MAPK1,MAPK3 0.038435 0.546693 Active sJIA vs. Healthy control GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS 469 80 10 XRCC6,HNRNPA2B1,HSP90AA1,IGHA1,IL6,MAPK1,MAPK3,PTPN11,SFTPD,TFF1 0.039692 0.546693 Active sJIA vs. Healthy control GO_NEUTROPHIL_HOMEOSTASIS 16 5 2 ANXA1,IL6 0.040108 0.546693 Active sJIA vs. Healthy control GO_RESPONSE_TO_SALT_STRESS 27 5 2 EPO,XRCC6 0.040108 0.546693 Active sJIA vs. Healthy control GO_TELOMERE_CAPPING 55 5 2 MAPK1,MAPK3 0.040108 0.546693 Active sJIA vs. Healthy control GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS 28 5 2 ACAN,OMD 0.040108 0.546693 Active sJIA vs. Healthy control GO_PRIMARY_MIRNA_PROCESSING 13 5 2 HNRNPA2B1,IL6 0.040108 0.546693 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION 37 5 2 ANXA1,BPI 0.040108 0.546693 Active sJIA vs. Healthy control GO_RESPONSE_TO_VITAMIN_A 19 5 2 EPO,ARG1 0.040108 0.546693 Active sJIA vs. Healthy control GO_REGULATION_OF_MACROPHAGE_PROLIFERATION 8 5 2 MAPK1,MAPK3 0.040108 0.546693 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS 15 5 2 FAP,IL6 0.040108 0.546693 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH17 5 2 MCL1,MMP3 0.040108 0.546693 Active sJIA vs. Healthy control GO_REGULATION_OF_TELOMERE_CAPPING 26 5 2 MAPK1,MAPK3 0.040108 0.546693 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING 17 5 2 MAPK1,MAPK3 0.040108 0.546693 Active sJIA vs. Healthy control GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION 396 115 13 COL8A1,HAPLN1,CTSV,ACAN,FAP,IL6,ITGA2B,MMP1,MMP3,MMP8,MMP9,BCAN,MIA 0.041723 0.546743 Active sJIA vs. Healthy control GO_RESPONSE_TO_WOUNDING 656 188 19 KLK8,CD109,EPO,F2,F9,FAP,FYN,ANXA1,IL6,ITGA2B,ARG1,MDK,PPP3CA,MAPK1,MAPK3,PRTN3,CD177,PTPN11,SAA1 0.041907 0.546743 Active sJIA vs. Healthy control GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS 115 20 4 ACAN,GPC3,OMD,BCAN 0.042016 0.546743 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT 128 20 4 PPIF,EPO,GSK3A,MMP9 0.042016 0.546743 Active sJIA vs. Healthy control GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION 75 20 4 F2,IL6,MDK,CNTN2 0.042016 0.546743 Active sJIA vs. Healthy control GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS 101 20 4 FYN,HGF,MCL1,MMP3 0.042016 0.546743 Active sJIA vs. Healthy control GO_RESPONSE_TO_NITROGEN_COMPOUND 1145 176 18 MAPK14,GRK2,FYN,GSK3A,ANXA1,IL6,ARG1,MMP3,MMP9,PKM,PPP3CA,MAPK1,MAPK3,RETN,PTPN11,TFF1,COLEC12,KYNU 0.042902 0.546743 Active sJIA vs. Healthy control GO_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS 49 12 3 F2,FAP,IL6 0.042922 0.546743 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION19 12 3 APOB,IL18,PLA2G2A 0.042922 0.546743 Active sJIA vs. Healthy control GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA49 12 3 PPIF,HGF,MMP9 0.042922 0.546743 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION54 12 3 MDK,CDON,DLL4 0.042922 0.546743 CKB,MAPK14,EPO,F2,FTH1,FYN,XRCC6,ANXA1,HK2,HNRNPA2B1,HSP90AA1,APOB,IGHA1,IL6,IL18,LCN2,MCL1,PLA2G2A,PPP3CA,MAPK1 Active sJIA vs. Healthy control GO_HOMEOSTATIC_PROCESS 1963 279 26 ,MAPK3,PTPN11,S100A9,SAA1,SFTPD,TFF1 0.043677 0.553075 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS106 39 6 CRP,MAPK14,F2,HSP90AA1,MMP8,CD177 0.044321 0.557922 Active sJIA vs. Healthy control GO_OSSIFICATION 410 93 11 MAPK14,FGR,GPC3,HGF,IL6,MDK,OMD,MAPK1,MAPK3,PTPN11,MRC2 0.044985 0.562967 PPIF,MAPK14,EPO,FYN,SLITRK5,GPC3,GSK3A,ANXA1,HGF,HK2,HNRNPA2B1,HSP90AA1,IL6,LCN2,MDK,MMP1,MMP3,MMP9,PPP3CA,MAP Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION1217 229 22 K1,MAPK3,S100A9 0.047791 0.580731 Active sJIA vs. Healthy control GO_APOPTOTIC_MITOCHONDRIAL_CHANGES 125 30 5 PPIF,GSK3A,HGF,HK2,MMP9 0.048106 0.580731 Active sJIA vs. Healthy control GO_INTERACTION_WITH_SYMBIONT 93 30 5 CRP,F2,GAPDH,ARG1,SFTPD 0.048106 0.580731 Active sJIA vs. Healthy control GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS 725 94 11 AKR1A1,GAPDH,GPI,ANXA1,APOB,IMPDH1,LTA4H,MST1,PKM,BCAN,KYNU 0.048125 0.580731 Active sJIA vs. Healthy control GO_REGULATION_OF_DNA_METABOLIC_PROCESS 365 50 7 GSK3A,HGF,HNRNPA2B1,HSP90AA1,IL6,MAPK1,MAPK3 0.048231 0.580731 Active sJIA vs. Healthy control GO_AMINOGLYCAN_CATABOLIC_PROCESS 67 21 4 ACAN,GPC3,OMD,BCAN 0.049278 0.580731 Active sJIA vs. Healthy control GO_RESPONSE_TO_CADMIUM_ION 64 21 4 ARG1,MMP9,MAPK1,MAPK3 0.049278 0.580731 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS 80 21 4 MAPK14,F2,FYN,MAPK1 0.049278 0.580731 Active sJIA vs. Healthy control GO_AGING 319 83 10 MAPK14,CTSV,EPO,GSK3A,ARG1,PPP3CA,MAPK1,MAPK3,RETN,KYNU 0.049457 0.580731 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION 462 142 15 LILRB2,MAPK14,FGR,XRCC6,GAPDH,IL36A,ANXA1,HGF,IL6,IL18,MDK,MMP8,PTPN11,SAA1,IL1RL1 0.049864 0.580731 CRP,FGR,FYN,XRCC6,GAPDH,IL36A,ANXA1,IGHA1,IL18,ARG1,LCN2,MRC1,CD177,PTPN11,S100A9,S100A12,SAA1,CCL16,SFTPD,BPI,COL Active sJIA vs. Healthy control GO_INNATE_IMMUNE_RESPONSE 986 230 22 EC12,KYNU 0.049898 0.580731 Active sJIA vs. Healthy control GO_INOSITOL_LIPID_MEDIATED_SIGNALING 196 61 8 EPO,F2,FGR,FYN,HGF,IL18,MAPK1,MAPK3 0.049918 0.580731 Active sJIA vs. Healthy control GO_CELLULAR_AMIDE_METABOLIC_PROCESS 1192 95 11 FUT5,GAPDH,GSK3A,IL6,ARG1,LTA4H,PKM,NAGK,MAPK1,MAPK3,KYNU 0.051413 0.580731 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION400 95 11 MAPK14,FGR,FYN,GAPDH,GPI,GSK3A,IL6,MMP8,MAPK1,SAA1,IL1RL1 0.051413 0.580731 Active sJIA vs. Healthy control GO_ENDODERM_FORMATION 55 13 3 COL8A1,MMP8,MMP9 0.053115 0.580731 Active sJIA vs. Healthy control GO_MATERNAL_PLACENTA_DEVELOPMENT 36 13 3 CTSV,MAPK1,MAPK3 0.053115 0.580731 Active sJIA vs. Healthy control GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION28 13 3 F2,GAPDH,ARG1 0.053115 0.580731 Active sJIA vs. Healthy control GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR 47 13 3 MAPK1,MAPK3,PTPN11 0.053115 0.580731 Active sJIA vs. Healthy control GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA54 13 3 HNRNPA2B1,IL6,PPP3CA 0.053115 0.580731 Active sJIA vs. Healthy control GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT 79 13 3 HSP90AA1,MAPK1,MAPK3 0.053115 0.580731 Active sJIA vs. Healthy control GO_GLIAL_CELL_DIFFERENTIATION 230 62 8 F2,IL6,MDK,MAPK1,MAPK3,PTPN11,S100A9,CNTN2 0.054196 0.580731 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE 158 62 8 IL6,IL18,MDK,MMP8,PLA2G2A,S100A9,S100A12,IL1RL1 0.054196 0.580731 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_TRANSPORT 944 207 20 MAPK14,GRK2,F2,FGR,FYN,GAPDH,GPC3,GPI,GSK3A,ANXA1,IL6,MMP8,PPP3CA,MAPK1,RETN,CD177,PTPN11,SAA1,SFTPD,IL1RL1 0.056153 0.580731 Active sJIA vs. Healthy control GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS 97 22 4 FYN,HGF,MCL1,MMP3 0.057191 0.580731 Active sJIA vs. Healthy control GO_TISSUE_REGENERATION 79 22 4 ANXA1,MDK,PKM,PPP3CA 0.057191 0.580731 Active sJIA vs. Healthy control GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY 64 22 4 CTSV,ARG1,MAPK1,MAPK3 0.057191 0.580731 Active sJIA vs. Healthy control GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS 21 6 2 FYN,MMP3 0.05753 0.580731 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE 22 6 2 CRP,IL6 0.05753 0.580731 Active sJIA vs. Healthy control GO_KERATAN_SULFATE_METABOLIC_PROCESS 33 6 2 ACAN,OMD 0.05753 0.580731 Active sJIA vs. Healthy control GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION 45 6 2 CD109,CTSV 0.05753 0.580731 Active sJIA vs. Healthy control GO_ORGANELLE_INHERITANCE 15 6 2 MAPK1,MAPK3 0.05753 0.580731 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_KILLING_OF_CELLS_OF_OTHER_ORGANISM11 6 2 GAPDH,ARG1 0.05753 0.580731 Active sJIA vs. Healthy control GO_TRACHEA_MORPHOGENESIS 11 6 2 MAPK1,MAPK3 0.05753 0.580731 Active sJIA vs. Healthy control GO_NEUTROPHIL_MEDIATED_CYTOTOXICITY 10 6 2 F2,ARG1 0.05753 0.580731 Active sJIA vs. Healthy control GO_NEUTROPHIL_MEDIATED_KILLING_OF_SYMBIONT_CELL 8 6 2 F2,ARG1 0.05753 0.580731 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS 42 6 2 EPO,XRCC6 0.05753 0.580731 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA28 6 2 PPIF,MMP9 0.05753 0.580731 Active sJIA vs. Healthy control GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS42 6 2 MAPK1,MAPK3 0.05753 0.580731 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS 22 6 2 MCL1,MMP3 0.05753 0.580731 Active sJIA vs. Healthy control GO_REGULATION_OF_T_HELPER_2_CELL_CYTOKINE_PRODUCTION 11 6 2 IL6,ARG1 0.05753 0.580731 Active sJIA vs. Healthy control GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT18 6 2 MAPK1,MAPK3 0.05753 0.580731 Active sJIA vs. Healthy control GO_GRANULOCYTE_CHEMOTAXIS 126 74 9 MAPK14,ANXA1,MDK,MAPK1,MAPK3,S100A9,S100A12,SAA1,CCL16 0.058196 0.584691 Active sJIA vs. Healthy control GO_HEAD_DEVELOPMENT 803 110 12 CKB,FYN,XRCC6,SLITRK5,MDK,CDON,PPP3CA,MAPK1,MAPK3,PTPN11,BCAN,CNTN2 0.062812 0.619789 Active sJIA vs. Healthy control GO_MONONUCLEAR_CELL_MIGRATION 96 64 8 MAPK14,ANXA1,IL6,MDK,MAPK1,MAPK3,S100A12,CCL16 0.063449 0.619789 CRP,F2,FGR,FYN,XRCC6,GAPDH,IL36A,ANXA1,IGHA1,IL6,IL18,ARG1,LCN2,MRC1,PLA2G2A,MAPK3,CD177,PTPN11,S100A9,S100A12,SAA Active sJIA vs. Healthy control GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM 1203 289 26 1,CCL16,SFTPD,BPI,COLEC12,KYNU 0.064327 0.619789 Active sJIA vs. Healthy control GO_SYNCYTIUM_FORMATION 60 14 3 CD109,MAPK14,CDON 0.064361 0.619789 Active sJIA vs. Healthy control GO_RESPONSE_TO_OSMOTIC_STRESS 85 14 3 EPO,ICOSLG,XRCC6 0.064361 0.619789 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_ION_TRANSMEMBRANE_TRANSPORT 103 14 3 PPIF,EPO,MMP9 0.064361 0.619789 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION 65 14 3 CRP,IL6,PTPN11 0.064361 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY147 23 4 GRK2,F2,GSK3A,CNTN2 0.065747 0.619789 Active sJIA vs. Healthy control GO_RESPONSE_TO_FUNGUS 54 23 4 GAPDH,ARG1,S100A9,S100A12 0.065747 0.619789 Active sJIA vs. Healthy control GO_ORGANIC_ACID_CATABOLIC_PROCESS 282 23 4 AKR1A1,ARG1,NAGK,KYNU 0.065747 0.619789 Active sJIA vs. Healthy control GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS 246 23 4 ANXA1,LTA4H,PKM,BCAN 0.065747 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_PROTEIN_LOCALIZATION 994 173 17 MAPK14,F2,FGR,FYN,GAPDH,GPC3,GPI,GSK3A,ANXA1,HSP90AA1,IL6,MMP8,PPP3CA,MAPK1,PTPN11,SAA1,IL1RL1 0.067648 0.619789 Active sJIA vs. Healthy control GO_CHEMICAL_HOMEOSTASIS 1213 173 17 CKB,EPO,F2,FTH1,FYN,HK2,APOB,IL6,IL18,LCN2,PPP3CA,MAPK1,MAPK3,PTPN11,S100A9,SAA1,SFTPD 0.067648 0.619789 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION 88 33 5 LILRB2,IL36A,IL6,MMP8,PTPN11 0.068273 0.619789 Active sJIA vs. Healthy control GO_DNA_BIOSYNTHETIC_PROCESS 191 33 5 HGF,HNRNPA2B1,HSP90AA1,MAPK1,MAPK3 0.068273 0.619789 Active sJIA vs. Healthy control GO_LEUKOCYTE_PROLIFERATION 313 124 13 LILRB2,CRP,EPO,ICOSLG,FYN,ANXA1,IL6,IL18,IMPDH1,ARG1,MAPK1,MAPK3,SFTPD 0.069956 0.619789 Active sJIA vs. Healthy control GO_LEUKOCYTE_CHEMOTAXIS 231 112 12 MAPK14,ANXA1,IL6,MDK,MST1,MAPK1,MAPK3,S100A9,S100A12,SAA1,CCL16,SFTPD 0.070363 0.619789 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE 383 112 12 FYN,XRCC6,IL6,IL18,ARG1,MDK,MMP8,PLA2G2A,MAPK3,S100A9,S100A12,IL1RL1 0.070363 0.619789 Active sJIA vs. Healthy control GO_NERVOUS_SYSTEM_PROCESS 1462 112 12 LILRB2,KLK8,FYN,GSK3A,HGF,MDK,DLL4,PPP3CA,MAPK1,MAPK3,CNTN2,CA6 0.070363 0.619789 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION 368 77 9 F2,ANXA1,HGF,IL6,ARG1,MMP8,SFTPD,BPI,IL1RL1 0.07175 0.619789 Active sJIA vs. Healthy control GO_GLIOGENESIS 307 77 9 F2,ANXA1,IL6,MDK,MAPK1,MAPK3,PTPN11,S100A9,CNTN2 0.07175 0.619789 Active sJIA vs. Healthy control GO_ACUTE_INFLAMMATORY_RESPONSE 111 44 6 CRP,EPO,F2,IL6,SAA1,CD163 0.073037 0.619789 Active sJIA vs. Healthy control GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION 142 24 4 PPIF,GSK3A,HK2,HSP90AA1 0.074935 0.619789 Active sJIA vs. Healthy control GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM 65 24 4 F2,GAPDH,ARG1,S100A12 0.074935 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION 32 15 3 IL6,IL18,ARG1 0.076609 0.619789 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSMEMBRANE_TRANSPORT45 15 3 MAPK14,GPC3,PTPN11 0.076609 0.619789 Active sJIA vs. Healthy control GO_LIPID_STORAGE 81 15 3 CRP,APOB,IL6 0.076609 0.619789 Active sJIA vs. Healthy control GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_CYTOKINE_PRODUCTION 23 15 3 IL6,IL18,ARG1 0.076609 0.619789 Active sJIA vs. Healthy control GO_KERATINOCYTE_PROLIFERATION 50 15 3 KLK8,CD109,MDK 0.076609 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION 53 15 3 MAPK14,IL18,CDON 0.076609 0.619789 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS66 15 3 FYN,HK2,MMP3 0.076609 0.619789 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE 16 7 2 IL6,IL18 0.077039 0.619789 Active sJIA vs. Healthy control GO_RESPONSE_TO_X_RAY 32 7 2 XRCC6,ANXA1 0.077039 0.619789 Active sJIA vs. Healthy control GO_RESPONSE_TO_AMINE 47 7 2 ARG1,PPP3CA 0.077039 0.619789 Active sJIA vs. Healthy control GO_CYTOSOLIC_TRANSPORT 165 7 2 MAPK1,MAPK3 0.077039 0.619789 Active sJIA vs. Healthy control GO_CEREBELLAR_CORTEX_DEVELOPMENT 50 7 2 MDK,PTPN11 0.077039 0.619789 Active sJIA vs. Healthy control GO_T_HELPER_2_CELL_CYTOKINE_PRODUCTION 15 7 2 IL6,ARG1 0.077039 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION 11 7 2 ANXA1,IL18 0.077039 0.619789 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION 22 7 2 MAPK14,CDON 0.077039 0.619789 Active sJIA vs. Healthy control GO_ARACHIDONIC_ACID_SECRETION 32 7 2 ANXA1,PLA2G2A 0.077039 0.619789 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION 11 7 2 GPI,IL6 0.077039 0.619789 Active sJIA vs. Healthy control GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS 26 7 2 GPI,HK2 0.077039 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_KILLING_OF_CELLS_OF_OTHER_ORGANISM 14 7 2 GAPDH,ARG1 0.077039 0.619789 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING22 7 2 IL6,PPP3CA 0.077039 0.619789 Active sJIA vs. Healthy control GO_TRACHEA_DEVELOPMENT 19 7 2 MAPK1,MAPK3 0.077039 0.619789 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA21 7 2 PPIF,HGF 0.077039 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS 41 7 2 FAP,IL6 0.077039 0.619789 Active sJIA vs. Healthy control GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS 104 7 2 ARG1,KYNU 0.077039 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_TAU_PROTEIN_KINASE_ACTIVITY 13 7 2 HGF,HSP90AA1 0.077039 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT 26 7 2 MAPK1,MAPK3 0.077039 0.619789 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MIRNAS_INVOLVED_IN_GENE_SILENCING_BY_MIRNA14 7 2 IL6,PPP3CA 0.077039 0.619789 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL23 7 2 IL6,MDK 0.077039 0.619789 Active sJIA vs. Healthy control GO_REGULATION_OF_METALLOPEPTIDASE_ACTIVITY 33 7 2 MAPK14,MAPK3 0.077039 0.619789 Active sJIA vs. Healthy control GO_CELLULAR_RESPONSE_TO_LIPID 588 126 13 LILRB2,MAPK14,IL36A,ANXA1,APOB,IL6,IL18,ARG1,LCN2,MRC1,MAPK1,MAPK3,BPI 0.077637 0.62226 Active sJIA vs. Healthy control GO_RESPONSE_TO_METAL_ION 365 67 8 PPIF,GSK3A,ARG1,MMP9,PPP3CA,MAPK1,MAPK3,TFF1 0.079098 0.629257 Active sJIA vs. Healthy control GO_PROCESS_UTILIZING_AUTOPHAGIC_MECHANISM 532 67 8 GAPDH,GSK3A,HGF,HK2,HSP90AA1,MCL1,MAPK3,S100A9 0.079098 0.629257 Active sJIA vs. Healthy control GO_T_CELL_PROLIFERATION 195 79 9 LILRB2,EPO,ICOSLG,FYN,ANXA1,IL6,IL18,ARG1,SFTPD 0.081808 0.647866 Active sJIA vs. Healthy control GO_WOUND_HEALING 536 152 15 CD109,F2,F9,FAP,FYN,ANXA1,IL6,ITGA2B,PPP3CA,MAPK1,MAPK3,PRTN3,CD177,PTPN11,SAA1 0.082043 0.647866 Active sJIA vs. Healthy control GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION 240 103 11 LILRB2,CRP,EPO,ICOSLG,ANXA1,IL6,IL18,ARG1,MAPK1,MAPK3,SFTPD 0.083306 0.655422 Active sJIA vs. Healthy control GO_AMINOGLYCAN_METABOLIC_PROCESS 172 35 5 ACAN,GPC3,HGF,OMD,BCAN 0.083977 0.655661 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION 207 68 8 LILRB2,F2,FGR,ANXA1,ARG1,MDK,SFTPD,BPI 0.084791 0.655661 Active sJIA vs. Healthy control GO_TRANSMEMBRANE_TRANSPORT 1608 104 11 PPIF,MAPK14,EPO,F2,FYN,GPC3,GSK3A,HK2,MCL1,MMP9,PTPN11 0.088015 0.655661 Active sJIA vs. Healthy control GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA 60 16 3 PPIF,HGF,MMP9 0.0898 0.655661 Active sJIA vs. Healthy control GO_ICOSANOID_METABOLIC_PROCESS 122 16 3 ANXA1,LTA4H,MAPK3 0.0898 0.655661 Active sJIA vs. Healthy control GO_SENSORY_PERCEPTION_OF_PAIN 106 16 3 FYN,MAPK1,MAPK3 0.0898 0.655661 Active sJIA vs. Healthy control GO_PANCREAS_DEVELOPMENT 79 16 3 GSK3A,ANXA1,IL6 0.0898 0.655661 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION 26 16 3 EPO,ICOSLG,IL18 0.0898 0.655661 Active sJIA vs. Healthy control GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT 168 16 3 MAPK14,CDON,PPP3CA 0.0898 0.655661 Active sJIA vs. Healthy control GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS 175 16 3 ANXA1,LTA4H,MAPK3 0.0898 0.655661 Active sJIA vs. Healthy control GO_LEUKOCYTE_CELL_CELL_ADHESION 364 129 13 LILRB2,EPO,ICOSLG,FYN,ANXA1,IL6,IL18,ARG1,MDK,CD177,PTPN11,S100A9,SFTPD 0.090164 0.655661 Active sJIA vs. Healthy control GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION 1193 69 8 MAPK14,GAPDH,HNRNPA2B1,IL6,PKM,PPP3CA,MAPK1,MAPK3 0.090723 0.655661 Active sJIA vs. Healthy control GO_ORGANOPHOSPHATE_METABOLIC_PROCESS 1057 117 12 AKR1A1,CKB,CKM,FGR,GAPDH,GPI,HK2,IMPDH1,PKM,PLA2G2A,MAPK1,KYNU 0.091785 0.655661 Active sJIA vs. Healthy control GO_CELLULAR_HOMEOSTASIS 971 142 14 CKB,EPO,F2,FTH1,FYN,HK2,IL6,LCN2,MCL1,PPP3CA,MAPK1,MAPK3,S100A9,SAA1 0.09235 0.655661 Active sJIA vs. Healthy control GO_REGULATION_OF_PEPTIDE_TRANSPORT 709 142 14 MAPK14,FGR,FYN,GAPDH,GPI,GSK3A,ANXA1,IL6,MMP8,PPP3CA,MAPK1,PTPN11,SAA1,IL1RL1 0.09235 0.655661 Active sJIA vs. Healthy control GO_TELENCEPHALON_DEVELOPMENT 259 36 5 SLITRK5,MDK,CDON,BCAN,CNTN2 0.092493 0.655661 Active sJIA vs. Healthy control GO_LIPID_LOCALIZATION 440 58 7 CRP,ANXA1,APOB,IL6,PLA2G2A,RETN,PTPN11 0.093394 0.655661 Active sJIA vs. Healthy control GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS 226 58 7 CTSV,EPO,ARG1,MMP9,PAPPA,MAPK1,MAPK3 0.093394 0.655661 Active sJIA vs. Healthy control GO_RESPONSE_TO_TOXIC_SUBSTANCE 250 47 6 AKR1A1,ARG1,LCN2,MAPK1,MAPK3,S100A9 0.094436 0.655661 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING88 47 6 EPO,F2,FGR,FYN,HGF,IL18 0.094436 0.655661 Active sJIA vs. Healthy control GO_REGULATION_OF_MACROPHAGE_ACTIVATION 59 26 4 IL6,MMP8,BPI,IL1RL1 0.095144 0.655661 Active sJIA vs. Healthy control GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS 100 26 4 AKR1A1,GAPDH,GPI,MST1 0.095144 0.655661 Active sJIA vs. Healthy control GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS 52 26 4 MAPK14,MDK,MAPK1,MAPK3 0.095144 0.655661 Active sJIA vs. Healthy control GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS 127 26 4 MAPK14,F2,FYN,MAPK1 0.095144 0.655661 Active sJIA vs. Healthy control GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS 268 26 4 IMPDH1,PKM,MAPK1,KYNU 0.095144 0.655661 Active sJIA vs. Healthy control GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS 113 26 4 ACAN,HGF,OMD,BCAN 0.095144 0.655661 LILRB2,MAPK14,GRK2,FGR,FYN,GAPDH,SLITRK5,GPC3,GSK3A,ANXA1,HGF,IL6,IL18,MDK,MMP8,PPP3CA,MAPK1,RETN,PTPN11,S100A9,S10 Active sJIA vs. Healthy control GO_CELL_CELL_SIGNALING 1809 301 26 0A12,SAA1,CCL16,CNTN2,TNFAIP6,IL1RL1 0.09753 0.655661 Active sJIA vs. Healthy control GO_AUTOPHAGY_OF_MITOCHONDRION 79 8 2 GSK3A,HK2 0.098276 0.655661 Active sJIA vs. Healthy control GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS 113 8 2 LTA4H,MAPK3 0.098276 0.655661 Active sJIA vs. Healthy control GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE16 8 2 MDK,S100A9 0.098276 0.655661 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE 14 8 2 ANXA1,ARG1 0.098276 0.655661 Active sJIA vs. Healthy control GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS 124 8 2 ARG1,KYNU 0.098276 0.655661 Active sJIA vs. Healthy control GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY 17 8 2 FAP,IL6 0.098276 0.655661 Active sJIA vs. Healthy control GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS 64 8 2 ACAN,BCAN 0.098276 0.655661 Active sJIA vs. Healthy control GO_THYROID_GLAND_DEVELOPMENT 21 8 2 MAPK1,MAPK3 0.098276 0.655661 Active sJIA vs. Healthy control GO_RESPONSE_TO_GONADOTROPIN 27 8 2 CTSV,PAPPA 0.098276 0.655661 Active sJIA vs. Healthy control GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION 25 8 2 FGR,CD177 0.098276 0.655661 Active sJIA vs. Healthy control GO_T_HELPER_2_CELL_DIFFERENTIATION 15 8 2 ANXA1,IL18 0.098276 0.655661 Active sJIA vs. Healthy control GO_THYMUS_DEVELOPMENT 46 8 2 MAPK1,MAPK3 0.098276 0.655661 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_GENE_SILENCING 36 8 2 IL6,PPP3CA 0.098276 0.655661 Active sJIA vs. Healthy control GO_MACROPHAGE_PROLIFERATION 12 8 2 MAPK1,MAPK3 0.098276 0.655661 Active sJIA vs. Healthy control GO_RESPONSE_TO_DEXAMETHASONE 41 8 2 EPO,ARG1 0.098276 0.655661 Active sJIA vs. Healthy control GO_LIVER_MORPHOGENESIS 22 8 2 IL6,MDK 0.098276 0.655661 Active sJIA vs. Healthy control GO_CELL_AGGREGATION 24 8 2 MAPK14,ACAN 0.098276 0.655661 Active sJIA vs. Healthy control GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS 202 8 2 ARG1,KYNU 0.098276 0.655661 Active sJIA vs. Healthy control GO_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION 43 8 2 GSK3A,HK2 0.098276 0.655661 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS 88 8 2 MAPK14,HNRNPA2B1 0.098276 0.655661 Active sJIA vs. Healthy control GO_NEGATIVE_REGULATION_OF_SYNAPSE_ORGANIZATION 25 8 2 LILRB2,FYN 0.098276 0.655661 Active sJIA vs. Healthy control GO_REGULATION_OF_PEPTIDE_SECRETION 432 94 10 FGR,GAPDH,GPI,ANXA1,IL6,MMP8,PPP3CA,PTPN11,SAA1,IL1RL1 0.098655 0.655661 Active sJIA vs. Healthy control GO_PEPTIDYL_SERINE_MODIFICATION 333 94 10 MAPK14,GRK2,EPO,GSK3A,HGF,HSP90AA1,IL6,MST1,MAPK1,MAPK3 0.098655 0.655661 MAS vs. active sJIA GO_ANTIMICROBIAL_HUMORAL_RESPONSE 137 49 14 CXCL13,GNLY,F2,HRG,IGHM,LCN2,CXCL9,PI3,PLA2G2A,PRSS2,PRTN3,S100A9,S100A12,H2BC21 1.86E-05 0.044402 NAMPT,MAPK14,F2,FCGR3B,FGG,ICOSLG,FTH1,GDI2,GPI,HRG,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IGFBP2,IGHM,IL18,LAG3,LBP,LCN2, LEP,LGALS9,MDK,MPO,PRDX1,CLEC1B,PDGFA,PDGFB,PGAM1,PLA2G2A,PRKCZ,MAPK3,PRSS2,PRTN3,BAD,PTPN6,PTPN11,RAC1,S100A9, MAS vs. active sJIA GO_CELL_ACTIVATION 1475 374 50 S100A12,SAA1,STAT3,TNFRSF1B,VWF,YES1,YWHAZ,CAT,IL1RL1,CD27,CD36 3.73E-05 0.04441 MAS vs. active sJIA GO_COAGULATION 349 95 19 F2,FAP,FGG,HGFAC,HRG,CLEC1B,PDGFA,PDGFB,PRKACA,MAPK3,PRTN3,PTPN6,PTPN11,RAC1,SAA1,VWF,YWHAZ,H3C1,CD36 0.000141 0.098608 CRP,MAPK14,F2,FCER2,FCGR3B,FTH1,GDI2,GPI,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IGHM,IL1R1,IL18,LAG3,LBP,LCN2,LEP,LGALS9,MDK ,CXCL9,MPO,PRDX1,PGAM1,PRKCZ,MAPK3,PRSS2,PRTN3,PTPN6,RAC1,S100A9,S100A12,STAT1,STAT3,TNFRSF1B,YES1,CAT,FCN3,CD27, MAS vs. active sJIA GO_IMMUNE_EFFECTOR_PROCESS 1292 300 41 CD36 0.00019 0.098608 MAS vs. active sJIA GO_PLATELET_ACTIVATION 158 46 12 F2,FGG,HRG,CLEC1B,PDGFA,PDGFB,MAPK3,PTPN6,PTPN11,SAA1,VWF,YWHAZ 0.000207 0.098608 CRP,MAPK14,F2,FCER2,FCGR3B,FTH1,GDI2,GPI,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IGHM,IL1R1,IL18,LAG3,LCN2,LEP,LGALS9,MPO,PR MAS vs. active sJIA GO_LEUKOCYTE_MEDIATED_IMMUNITY 885 225 33 DX1,PGAM1,PRKCZ,PRSS2,PRTN3,PTPN6,RAC1,S100A9,S100A12,TNFRSF1B,CAT,CD27,CD36 0.00028 0.111357 MAS vs. active sJIA GO_DEFENSE_RESPONSE_TO_BACTERIUM 341 81 16 CXCL13,GNLY,CRP,F2,IGHM,LBP,LCN2,MPO,PI3,PLA2G2A,HAMP,S100A9,S100A12,SHC1,H2BC21,CD36 0.000593 0.185039 MAS vs. active sJIA GO_REGULATION_OF_BODY_FLUID_LEVELS 513 115 20 F2,FAP,FGG,GPI,HGFAC,HRG,CLEC1B,PDGFA,PDGFB,PRKACA,MAPK3,PRTN3,PTPN6,PTPN11,RAC1,SAA1,VWF,YWHAZ,H3C1,CD36 0.000685 0.185039 MAS vs. active sJIA GO_HUMORAL_IMMUNE_RESPONSE 370 107 19 CXCL13,GNLY,CRP,F2,FCER2,GPI,HRG,IGHM,LCN2,CXCL9,PI3,PLA2G2A,PRSS2,PRTN3,PTPN6,S100A9,S100A12,H2BC21,FCN3 0.000726 0.185039 MAS vs. active sJIA GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS 100 26 8 AKR1A1,ENO1,GPI,LEP,MDH1,PGAM1,TKT,TPI1 0.000777 0.185039 MAS vs. active sJIA GO_OXIDATION_REDUCTION_PROCESS 1014 84 16 AKR1A1,MAPK14,ADSL,ENO1,FTH1,GPI,LDHB,LEP,MDH1,MPO,PRDX1,PGAM1,POR,TKT,TPI1,CAT 0.000909 0.190158 NAMPT,MAPK14,ENO1,F2,FAP,FGG,BMP10,HTRA2,HRG,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IL1R1,IL18,LAG3,LBP,LEP,LGALS9,MCL1, MDK,PRDX1,PDGFA,PDGFB,PLA2G2A,PRKACA,MAPK3,MAP2K1,BAD,PTPN6,PTPN11,S100A9,S100A12,SAA1,MAP2K4,STAT1,STAT3,TNFR MAS vs. active sJIA GO_REGULATION_OF_RESPONSE_TO_STRESS 1538 332 42 SF1B,TPT1,IL1RL1,CD27,CD36 0.000958 0.190158 MAS vs. active sJIA GO_MONOSACCHARIDE_CATABOLIC_PROCESS 66 16 6 AKR1A1,ENO1,GPI,PGAM1,BAD,TPI1 0.001158 0.211449 MAPK14,F2,FCGR3B,FTH1,GDI2,GPI,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,LCN2,LGALS9,MPO,PGAM1,PRSS2,PRTN3,PTPN6,RAC1,S100A MAS vs. active sJIA GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY 555 147 23 9,S100A12,TNFRSF1B,CAT,CD36 0.001243 0.211449 MAS vs. active sJIA GO_CELL_KILLING 172 71 14 GNLY,F2,FCER2,HRG,HSP90AB1,IL18,LAG3,LEP,LGALS9,PRDX1,BAD,PTPN6,HAMP,S100A12 0.001376 0.218431 MAPK14,FCGR3B,FTH1,GDI2,GPI,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IL18,LBP,LCN2,LGALS9,MDK,MPO,PGAM1,PRKCZ,PRSS2,PRTN3,P MAS vs. active sJIA GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE 720 187 27 TPN6,RAC1,S100A9,S100A12,STAT3,TNFRSF1B,CAT,CD36 0.00158 0.22344 NAMPT,MAPK14,FCGR3B,FTH1,GDI2,GPI,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IL18,LBP,LCN2,LGALS9,MPO,PGAM1,PLA2G2A,PRSS2,PR MAS vs. active sJIA GO_MYELOID_LEUKOCYTE_ACTIVATION 662 188 27 TN3,PTPN6,RAC1,S100A9,S100A12,TNFRSF1B,CAT,IL1RL1,CD36 0.00172 0.22344 MAS vs. active sJIA GO_ANTIMICROBIAL_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_ANTIMICROBIAL_PEPTIDE75 29 8 CXCL13,GNLY,F2,HRG,CXCL9,S100A9,S100A12,H2BC21 0.001726 0.22344 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_HEAT 125 23 7 HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,PRKACA,MAPK3 0.001816 0.22344 MAS vs. active sJIA GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS 288 74 14 CRP,MAPK14,F2,HSP90AA1,HSP90AB1,LEP,MPO,PRDX1,PDGFB,POR,RAC1,STAT3,CAT,CD36 0.002101 0.22344 MAS vs. active sJIA GO_DEFENSE_RESPONSE_TO_FUNGUS 41 18 6 GNLY,HRG,MPO,HAMP,S100A9,S100A12 0.002338 0.22344 MAS vs. active sJIA GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY 534 59 12 AKR1A1,ADSL,ENO1,GPI,LEP,MDH1,PGAM1,POR,STAT3,TKT,TPI1,CAT 0.002345 0.22344 MAS vs. active sJIA GO_REGULATION_OF_INTRACELLULAR_TRANSPORT 357 59 12 MAPK14,HTRA2,HSP90AB1,LEP,PRKACA,MAPK3,MAP2K1,BAD,PTPN11,YWHAB,YWHAZ,CD36 0.002345 0.22344 MAS vs. active sJIA GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM 65 24 7 GNLY,F2,FCER2,HRG,BAD,HAMP,S100A12 0.002391 0.22344 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION 19 8 4 F2,FGG,PDGFA,PDGFB 0.002442 0.22344 MAS vs. active sJIA GO_REGULATION_OF_METANEPHROS_DEVELOPMENT 23 8 4 PDGFA,PDGFB,RET,STAT1 0.002442 0.22344 MAPK14,FCGR3B,FGG,FTH1,GDI2,GPI,HRG,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,LCN2,LGALS9,MPO,PDGFA,PDGFB,PGAM1,SERPINA4, MAS vs. active sJIA GO_EXOCYTOSIS 914 203 28 PRSS2,PRTN3,PTPN6,RAC1,S100A9,S100A12,TNFRSF1B,VWF,CAT,CD36 0.002641 0.22344 MAS vs. active sJIA GO_GLUCOSE_CATABOLIC_PROCESS 36 13 5 ENO1,GPI,PGAM1,BAD,TPI1 0.00272 0.22344 MAS vs. active sJIA GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT 79 13 5 HSPA1A,HSPA8,HSP90AA1,HSP90AB1,MAPK3 0.00272 0.22344 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION400 95 16 MAPK14,FGG,HTRA2,GPI,HSP90AB1,LEP,LGALS9,PRKACA,PRKCZ,BAD,RAC1,SAA1,STAT3,YWHAB,YWHAZ,IL1RL1 0.00357 0.259835 MAS vs. active sJIA GO_RESPONSE_TO_TOXIC_SUBSTANCE 250 47 10 AKR1A1,HTRA2,LCN2,MPO,PRDX1,APOM,MAPK3,S100A9,CAT,CD36 0.003894 0.259835 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE 122 26 7 AKR1A1,MPO,PRDX1,APOM,S100A9,CAT,CD36 0.003951 0.259835 MAS vs. active sJIA GO_DETOXIFICATION 138 26 7 AKR1A1,MPO,PRDX1,APOM,S100A9,CAT,CD36 0.003951 0.259835 MAS vs. active sJIA GO_NADH_METABOLIC_PROCESS 41 14 5 ENO1,GPI,MDH1,PGAM1,TPI1 0.003954 0.259835 MAS vs. active sJIA GO_TRANSITION_METAL_ION_TRANSPORT 129 9 4 FTH1,HRG,LCN2,HAMP 0.004115 0.259835 MAS vs. active sJIA GO_IRON_ION_TRANSPORT 79 9 4 FTH1,HRG,LCN2,HAMP 0.004115 0.259835 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION 34 9 4 MAPK14,HSPA1A,STAT1,STAT3 0.004115 0.259835 MAS vs. active sJIA GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS 213 40 9 AKR1A1,ENO1,GPI,LEP,MDH1,PDGFB,PGAM1,TKT,TPI1 0.004145 0.259835 MAS vs. active sJIA GO_MEGAKARYOCYTE_DEVELOPMENT 17 5 3 PTPN6,PTPN11,THPO 0.00495 0.280713 MAS vs. active sJIA GO_PLATELET_MORPHOGENESIS 22 5 3 CLEC1B,PTPN6,PTPN11 0.00495 0.280713 MAS vs. active sJIA GO_PROTEIN_REFOLDING 23 5 3 HSPA1A,HSPA8,HSP90AA1 0.00495 0.280713 MAS vs. active sJIA GO_RESPONSE_TO_LIPOTEICHOIC_ACID 10 5 3 MAPK14,LBP,CD36 0.00495 0.280713 MAS vs. active sJIA GO_CARBOHYDRATE_METABOLIC_PROCESS 630 81 14 AKR1A1,MAPK14,ENO1,GPI,LDHB,LEP,MDH1,PDGFB,PGAM1,NAGK,BAD,STAT3,TKT,TPI1 0.005081 0.281482 MAS vs. active sJIA GO_MAINTENANCE_OF_LOCATION 324 57 11 CRP,F2,FTH1,LCN2,LEP,CXCL9,PRKACA,PTPN6,S100A9,YWHAB,CD36 0.005516 0.287063 MAS vs. active sJIA GO_REGULATION_OF_PLATELET_ACTIVATION 36 15 5 F2,FGG,HRG,PDGFA,PDGFB 0.005544 0.287063 MAS vs. active sJIA GO_HEXOSE_CATABOLIC_PROCESS 56 15 5 ENO1,GPI,PGAM1,BAD,TPI1 0.005544 0.287063 NAMPT,AKR1A1,CXCL13,MAPK14,GRK2,HTRA2,IL18,LBP,LCN2,LEP,CXCL9,MPO,MRC1,PRDX1,PDGFB,POR,PRKACA,PRKCZ,MAPK3,BAD,P MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND 1220 244 31 TPN11,HAMP,RAC1,RET,MAP2K4,SHC1,STAT1,STAT3,TNFRSF1B,YES1,CD36 0.00573 0.290392 MAS vs. active sJIA GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS 672 74 13 AKR1A1,MAPK14,ENO1,GPI,LDHB,LEP,PGAM1,POR,MAPK3,ASAH2,STAT3,TPI1,CD36 0.006017 0.296461 MAPK14,ENO1,F2,FGG,GDI2,HTRA2,HSPA1A,HSP90AA1,HSP90AB1,IL18,ITGA1,LEP,LGALS9,MCL1,PRDX1,CDON,PDGFA,PDGFB,PLA2G2 A,PRKACA,PRKCZ,MAPK3,MAP2K1,BAD,PTPN6,PTPN11,RAC1,RET,S100A9,S100A12,SAA1,MAP2K4,SHC1,STAT1,THPO,TPT1,UBE2I,YWHA MAS vs. active sJIA GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION 1864 351 41 Z,CAT,CD27,CD36 0.006098 0.296461 MAS vs. active sJIA GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT 263 51 10 MAPK14,HTRA2,HSP90AB1,LEP,PRKACA,BAD,PTPN11,YWHAB,YWHAZ,CD36 0.007225 0.344215 MAS vs. active sJIA GO_NAD_METABOLIC_PROCESS 50 16 5 ENO1,GPI,MDH1,PGAM1,TPI1 0.007537 0.345252 MAS vs. active sJIA GO_RESPONSE_TO_INTERLEUKIN_6 55 16 5 FGG,PTPN11,HAMP,STAT1,STAT3 0.007537 0.345252 MAS vs. active sJIA GO_RESPONSE_TO_FUNGUS 54 23 6 GNLY,HRG,MPO,HAMP,S100A9,S100A12 0.009005 0.363225 MAS vs. active sJIA GO_CELLULAR_OXIDANT_DETOXIFICATION 103 23 6 MPO,PRDX1,APOM,S100A9,CAT,CD36 0.009005 0.363225 MAS vs. active sJIA GO_AEROBIC_RESPIRATION 87 6 3 ADSL,MDH1,CAT 0.009302 0.363225 MAS vs. active sJIA GO_LIPID_DIGESTION 21 6 3 LEP,ASAH2,CD36 0.009302 0.363225 MAS vs. active sJIA GO_ORGANELLE_INHERITANCE 15 6 3 MAPK3,MAP2K1,YWHAZ 0.009302 0.363225 MAS vs. active sJIA GO_BERGMANN_GLIAL_CELL_DIFFERENTIATION 8 6 3 MAPK3,MAP2K1,PTPN11 0.009302 0.363225 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS27 6 3 LEP,PRKCZ,PTPN11 0.009302 0.363225 MAS vs. active sJIA GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION 50 11 4 MAPK14,HSPA1A,STAT1,STAT3 0.009454 0.363225 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS16 11 4 NAMPT,FCER2,MAP2K4,STAT1 0.009454 0.363225 MAS vs. active sJIA GO_GLYCOLYTIC_PROCESS_THROUGH_FRUCTOSE_6_PHOSPHATE 29 11 4 ENO1,GPI,PGAM1,TPI1 0.009454 0.363225 MAS vs. active sJIA GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS 57 17 5 MPO,PRDX1,RAC1,STAT3,CAT 0.009982 0.3715 MAS vs. active sJIA GO_FOAM_CELL_DIFFERENTIATION 38 17 5 CRP,IL18,PLA2G2A,STAT1,CD36 0.009982 0.3715 MAS vs. active sJIA GO_GRANULOCYTE_MIGRATION 149 79 13 CXCL13,MAPK14,IL1R1,ITGA1,LBP,MDK,CXCL9,MAPK3,PRTN3,RAC1,S100A9,S100A12,SAA1 0.010598 0.383655 MAS vs. active sJIA GO_NEUTROPHIL_MIGRATION 121 62 11 CXCL13,IL1R1,ITGA1,LBP,MDK,CXCL9,PRTN3,RAC1,S100A9,S100A12,SAA1 0.01063 0.383655 MAS vs. active sJIA GO_MONOSACCHARIDE_METABOLIC_PROCESS 296 54 10 AKR1A1,MAPK14,ENO1,GPI,LEP,MDH1,PGAM1,BAD,TKT,TPI1 0.01093 0.388582 MAS vs. active sJIA GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION 142 24 6 HSPA1A,HSP90AA1,BAD,STAT3,YWHAB,YWHAZ 0.01121 0.390054 MAPK14,F2,FGG,HSPA1A,HSP90AA1,HSP90AB1,IL18,ITGA1,LEP,LGALS9,MCL1,CDON,PDGFA,PDGFB,PLA2G2A,PRKCZ,MAPK3,MAP2K1, MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION1054 276 33 BAD,PTPN6,PTPN11,RAC1,RET,S100A9,S100A12,SAA1,MAP2K4,SHC1,THPO,UBE2I,CAT,CD27,CD36 0.011299 0.390054 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS 326 63 11 NAMPT,CTSV,HSPA8,LCN2,LEP,MAPK3,BAD,PTPN11,RAC1,MAP2K4,DCTPP1 0.011991 0.401157 NAMPT,AKR1A1,CXCL13,MAPK14,CTSV,GRK2,HTRA2,HSP90AB1,IGFBP2,IL18,LBP,LCN2,LEP,LGALS9,CXCL9,MPO,MRC1,PRDX1,PDGFB,P MAS vs. active sJIA GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND 1714 342 39 OR,PRKACA,PRKCZ,APOM,MAPK3,BAD,PTPN11,HAMP,RAC1,RET,S100A9,MAP2K4,SHC1,STAT1,STAT3,TNFRSF1B,YES1,CAT,CD27,CD36 0.012163 0.401157 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS106 39 8 CRP,MAPK14,F2,HSP90AA1,HSP90AB1,LEP,PDGFB,CD36 0.012228 0.401157 MAS vs. active sJIA GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS 590 55 10 NAMPT,AKR1A1,ADSL,ENO1,PDGFA,PDGFB,PLA2G2A,STAT3,TKT,TPI1 0.012442 0.401157 MAS vs. active sJIA GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE 582 72 12 MAPK14,HTRA2,HSPA8,HSP90AA1,HSP90AB1,LEP,BAD,STAT3,YWHAB,YWHAZ,CAT,CD36 0.012678 0.401157 MAS vs. active sJIA GO_MEGAKARYOCYTE_DIFFERENTIATION 100 12 4 PTPN6,PTPN11,THPO,H3C1 0.013286 0.401157 MAS vs. active sJIA GO_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS 20 12 4 NAMPT,FCER2,MAP2K4,STAT1 0.013286 0.401157 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID 67 12 4 HTRA2,LEP,RET,YES1 0.013286 0.401157 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION 31 12 4 IL1R1,LBP,MDK,RAC1 0.013286 0.401157 MAS vs. active sJIA GO_CARBOHYDRATE_CATABOLIC_PROCESS 200 32 7 AKR1A1,ENO1,GPI,PGAM1,BAD,STAT3,TPI1 0.013305 0.401157 MAS vs. active sJIA GO_ORGANIC_ACID_METABOLIC_PROCESS 1183 118 17 AKR1A1,MAPK14,ENO1,GPI,LDHB,LEP,MDH1,MPO,PDGFB,PGAM1,POR,NAGK,MAPK3,ASAH2,STAT3,TPI1,CD36 0.013708 0.405268 CXCL13,CRP,MAPK14,F2,FCER2,ICOSLG,GPI,HRG,HSPA1A,HSP90AA1,HSP90AB1,IGFBP2,IGHM,IL1R1,IL18,LAG3,LBP,LEP,LGALS9,MDK,PR MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 1101 301 35 KACA,PRKCZ,MAPK3,BAD,PTPN6,PTPN11,RAC1,STAT1,STAT3,THPO,YES1,FCN3,IL1RL1,CD27,CD36 0.013806 0.405268 MAS vs. active sJIA GO_CEREBELLAR_CORTEX_DEVELOPMENT 50 7 3 MDK,MAP2K1,PTPN11 0.015301 0.405268 MAS vs. active sJIA GO_REGULATION_OF_RNA_SPLICING 155 7 3 HSPA1A,HSPA8,RBM39 0.015301 0.405268 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION 22 7 3 MAPK14,CXCL9,CDON 0.015301 0.405268 MAS vs. active sJIA GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY 22 7 3 HSPA1A,HSP90AA1,HSP90AB1 0.015301 0.405268 MAS vs. active sJIA GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS 26 7 3 GPI,PGAM1,TKT 0.015301 0.405268 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT 14 7 3 PDGFA,PDGFB,RET 0.015301 0.405268 MAS vs. active sJIA GO_NEUTROPHIL_EXTRAVASATION 14 7 3 IL1R1,MDK,PRTN3 0.015301 0.405268 MAS vs. active sJIA GO_REGULATION_OF_METALLOPEPTIDASE_ACTIVITY 33 7 3 MAPK14,MAPK3,STAT3 0.015301 0.405268 CXCL13,GNLY,CRP,MAPK14,F2,IGHM,IL18,LBP,LCN2,LGALS9,CXCL9,MPO,MRC1,PI3,PLA2G2A,MAPK3,HAMP,S100A9,S100A12,SHC1,TN MAS vs. active sJIA GO_RESPONSE_TO_BACTERIUM 743 178 23 FRSF1B,H2BC21,CD36 0.015492 0.405268 MAS vs. active sJIA GO_RESPONSE_TO_HEAT 166 33 7 HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,PRKACA,MAPK3 0.015753 0.405268 MAS vs. active sJIA GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION 559 92 14 MAPK14,F2,HTRA2,HSP90AA1,HSP90AB1,LEP,PRKACA,PRKCZ,BAD,PTPN11,SUMO3,YWHAB,YWHAZ,CD36 0.01593 0.405268 MAS vs. active sJIA GO_AGING 319 83 13 NAMPT,MAPK14,CTSV,HTRA2,IGFBP2,LEP,MPO,MAPK3,MAP2K1,HAMP,STAT3,TNFRSF1B,CAT 0.015941 0.405268 MAS vs. active sJIA GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN 48 19 5 CXCL13,HRG,PTPN6,PTPN11,RET 0.016398 0.405268 MAS vs. active sJIA GO_REGULATION_OF_PROTEIN_IMPORT 62 19 5 MAPK14,HSPA8,HSP90AB1,LEP,CD36 0.016398 0.405268 MAS vs. active sJIA GO_RESPONSE_TO_MONOSACCHARIDE 207 41 8 NAMPT,CTSV,LEP,PRKACA,APOM,BAD,RAC1,CAT 0.016503 0.405268 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT181 41 8 MAPK14,HTRA2,HSP90AB1,LEP,PRKACA,BAD,YWHAB,YWHAZ 0.016503 0.405268 MAS vs. active sJIA GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS 127 26 6 MAPK14,F2,HSP90AB1,LEP,SUMO3,CD36 0.016719 0.406382 MAS vs. active sJIA GO_PROTEIN_LOCALIZATION_TO_ORGANELLE 979 102 15 MAPK14,F2,HTRA2,HSPA8,HSP90AA1,HSP90AB1,LEP,PRKCZ,BAD,SUMO3,STAT3,YWHAB,YWHAZ,CAT,CD36 0.01715 0.412218 MAS vs. active sJIA GO_RESPONSE_TO_MECHANICAL_STIMULUS 209 58 10 MAPK14,IGFBP2,MDK,MPO,MAPK3,BAD,PTPN11,RAC1,MAP2K4,STAT1 0.017934 0.412218 MAS vs. active sJIA GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS200 58 10 CRP,MAPK14,F2,HSP90AA1,HSP90AB1,LEP,PDGFB,RAC1,STAT3,CD36 0.017934 0.412218 MAS vs. active sJIA GO_RESPIRATORY_BURST 37 13 4 LBP,MPO,PGAM1,RAC1 0.017981 0.412218 MAS vs. active sJIA GO_MITOCHONDRIAL_TRANSPORT 271 34 7 HTRA2,HSPA1A,HSP90AA1,BAD,STAT3,YWHAB,YWHAZ 0.018507 0.412218 MAS vs. active sJIA GO_CELL_PROJECTION_ASSEMBLY 587 34 7 HRG,HSP90AA1,PDGFA,PRKACA,RAC1,CAPG,NTN1 0.018507 0.412218 MAS vs. active sJIA GO_GLUCOSE_METABOLIC_PROCESS 214 50 9 AKR1A1,MAPK14,ENO1,GPI,LEP,MDH1,PGAM1,BAD,TPI1 0.018709 0.412218 MAS vs. active sJIA GO_PROCESS_UTILIZING_AUTOPHAGIC_MECHANISM 532 67 11 NAMPT,HTRA2,HSPA8,HSP90AA1,LEP,MCL1,PRKACA,MAPK3,BAD,S100A9,STAT3 0.01881 0.412218 NAMPT,MAPK14,HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,LEP,MCL1,PGAM1,PRKACA,MAPK3,BAD,STAT3,TNFRSF1B,YWHAB,YWH MAS vs. active sJIA GO_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS 872 122 17 AZ 0.018885 0.412218 CXCL13,GNLY,CRP,MAPK14,ENO1,F2,FAP,HRG,HSP90AB1,IGHM,IL18,LAG3,LBP,LCN2,LEP,LGALS9,CXCL9,MPO,MRC1,PRDX1,PI3,PLA2G2 MAS vs. active sJIA GO_RESPONSE_TO_BIOTIC_STIMULUS 1615 362 40 A,PRKACA,MAPK3,PRSS2,PRTN3,PTPN6,PTPN11,HAMP,S100A9,S100A12,SAA1,SHC1,STAT1,TNFRSF1B,TPT1,YES1,H2BC21,FCN3,CD36 0.018963 0.412218 MAS vs. active sJIA GO_ATP_METABOLIC_PROCESS 311 42 8 ENO1,GPI,HSPA1A,HSPA8,PGAM1,BAD,STAT3,TPI1 0.019006 0.412218 MAS vs. active sJIA GO_REGULATION_OF_PEPTIDE_TRANSPORT 709 142 19 MAPK14,FGG,HTRA2,GPI,HSPA8,HSP90AB1,LEP,LGALS9,PRKACA,PRKCZ,BAD,PTPN11,RAC1,SAA1,STAT3,YWHAB,YWHAZ,IL1RL1,CD36 0.019837 0.412218 MAS vs. active sJIA GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE93 27 6 MAPK14,F2,LBP,LEP,STAT3,CD36 0.020075 0.412218 MAS vs. active sJIA GO_PYRUVATE_METABOLIC_PROCESS 152 27 6 ENO1,GPI,LDHB,PGAM1,STAT3,TPI1 0.020075 0.412218 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_AUTOPHAGY 85 20 5 NAMPT,HTRA2,LEP,MCL1,STAT3 0.020446 0.412218 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_HEMOPOIESIS 204 68 11 MAPK14,HSPA1A,IL18,LGALS9,MDK,PRKCZ,BAD,STAT1,STAT3,THPO,CD27 0.020896 0.412218 MAS vs. active sJIA GO_RESPONSE_TO_CARBOHYDRATE 233 51 9 NAMPT,CTSV,LEP,PRKACA,APOM,BAD,RAC1,MAP2K4,CAT 0.02117 0.412218 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY159 51 9 HSPA1A,IL18,LGALS9,PRKCZ,S100A9,S100A12,STAT3,CAT,CD36 0.02117 0.412218 MAPK14,F2,HTRA2,HSPA8,HSP90AA1,HSP90AB1,LEP,PRKACA,PRKCZ,MAPK3,MAP2K1,BAD,PTPN11,STAT3,YWHAB,YWHAZ,CAT,NTN1,C MAS vs. active sJIA GO_INTRACELLULAR_TRANSPORT 1758 143 19 D36 0.021286 0.412218 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELL_ADHESION 428 153 20 CXCL13,FGG,ICOSLG,HRG,IGFBP2,IL18,LEP,LGALS9,MDK,PRKCZ,PRSS2,BAD,PTPN6,PTPN11,RAC1,RET,SAA1,YES1,CD27,CD36 0.021488 0.412218 MAPK14,F2,HTRA2,HSP90AA1,HSP90AB1,LEP,LGALS9,CXCL9,PRKACA,PRKCZ,MAPK3,MAP2K1,BAD,PTPN6,PTPN11,RAC1,SUMO3,YWHA MAS vs. active sJIA GO_REGULATION_OF_CELLULAR_LOCALIZATION 1011 153 20 B,YWHAZ,CD36 0.021488 0.412218 MAPK14,F2,FGG,HTRA2,GPI,HSPA8,HSP90AA1,HSP90AB1,LEP,LGALS9,PRKACA,PRKCZ,BAD,PTPN11,RAC1,SAA1,SUMO3,STAT3,YWHAB, MAS vs. active sJIA GO_REGULATION_OF_PROTEIN_LOCALIZATION 994 173 22 YWHAZ,IL1RL1,CD36 0.021501 0.412218 CXCL13,CRP,F2,FCER2,FCGR3B,ICOSLG,HRG,HSP90AA1,HSP90AB1,IGHM,IL1R1,IL18,LAG3,LBP,LEP,LGALS9,PRKACA,PRKCZ,MAPK3,PTPN MAS vs. active sJIA GO_REGULATION_OF_IMMUNE_RESPONSE 1018 256 30 6,PTPN11,RAC1,MAP2K4,SHC1,STAT1,TNFRSF1B,YES1,FCN3,IL1RL1,CD36 0.021637 0.412218 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT 221 43 8 MAPK14,HTRA2,HSP90AB1,LEP,PRKACA,BAD,YWHAB,YWHAZ 0.021771 0.412218 F2,FGG,ICOSLG,HRG,IGFBP2,IGHM,IL18,LAG3,LBP,LEP,LGALS9,MDK,PDGFA,PDGFB,PLA2G2A,PRKCZ,BAD,PTPN6,PTPN11,RAC1,TNFRSF1 MAS vs. active sJIA GO_REGULATION_OF_CELL_ACTIVATION 643 194 24 B,YES1,IL1RL1,CD27 0.022413 0.412218 CXCL13,GNLY,CRP,F2,HRG,HSP90AB1,IGHM,IL18,LAG3,LBP,LCN2,LEP,LGALS9,CXCL9,MPO,MRC1,PRDX1,PI3,PLA2G2A,PRKACA,MAPK3,P MAS vs. active sJIA GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM 1203 289 33 TPN6,PTPN11,HAMP,S100A9,S100A12,SAA1,SHC1,STAT1,YES1,H2BC21,FCN3,CD36 0.022639 0.412218 MAS vs. active sJIA GO_INTRACELLULAR_PROTEIN_TRANSPORT 1179 96 14 MAPK14,HTRA2,HSPA8,HSP90AA1,HSP90AB1,LEP,PRKACA,BAD,PTPN11,STAT3,YWHAB,YWHAZ,CAT,CD36 0.022698 0.412218 MAS vs. active sJIA GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS 507 96 14 NAMPT,CTSV,ADSL,HSPA8,IGFBP2,LCN2,LEP,MPO,POR,MAPK3,HAMP,STAT1,DCTPP1,CAT 0.022698 0.412218 CXCL13,FGG,HRG,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,MPO,PLA2G2A,PRKACA,PRKCZ,APOM,MAPK3,BAD,PTPN11,RAC1,CAPG,H2BC MAS vs. active sJIA GO_PROTEIN_CONTAINING_COMPLEX_SUBUNIT_ORGANIZATION 1978 164 21 21,H3C1,H2AW,CD36 0.023002 0.412218 MAS vs. active sJIA GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE16 8 3 LBP,MDK,S100A9 0.023016 0.412218 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN21 8 3 CXCL13,PTPN6,RET 0.023016 0.412218 MAS vs. active sJIA GO_NUCLEOSOME_ORGANIZATION 183 8 3 H2BC21,H3C1,H2AW 0.023016 0.412218 MAS vs. active sJIA GO_INTESTINAL_ABSORPTION 40 8 3 LEP,HAMP,CD36 0.023016 0.412218 MAS vs. active sJIA GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY35 8 3 HSP90AB1,PTPN6,PTPN11 0.023016 0.412218 MAS vs. active sJIA GO_METANEPHRIC_NEPHRON_DEVELOPMENT 40 8 3 PDGFB,RET,STAT1 0.023016 0.412218 MAS vs. active sJIA GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRIAL_MEMBRANE49 14 4 HSP90AA1,BAD,YWHAB,YWHAZ 0.023592 0.414918 MAS vs. active sJIA GO_REGULATION_OF_NEUTROPHIL_MIGRATION 42 14 4 IL1R1,LBP,MDK,RAC1 0.023592 0.414918 MAS vs. active sJIA GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY 66 28 6 IL18,LAG3,LEP,LGALS9,PRDX1,PTPN6 0.023864 0.414918 MAS vs. active sJIA GO_ACUTE_PHASE_RESPONSE 47 28 6 CRP,F2,LBP,HAMP,SAA1,STAT3 0.023864 0.414918 MAS vs. active sJIA GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN 204 21 5 HSPA1A,HSPA8,HSP90AA1,HSP90AB1,SHC1 0.0251 0.427055 MAS vs. active sJIA GO_REGULATION_OF_CARTILAGE_DEVELOPMENT 71 21 5 BMP10,LEP,MDK,POR,PTPN11 0.0251 0.427055 MAS vs. active sJIA GO_REGULATION_OF_MEMBRANE_PERMEABILITY 88 21 5 HSPA1A,BAD,STAT3,YWHAB,YWHAZ 0.0251 0.427055 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_RNA_BIOSYNTHETIC_PROCESS 1365 107 15 ENO1,HSPA1A,HSPA8,LEP,PDGFB,HAMP,SHC1,STAT1,STAT3,UBE2I,YWHAB,H3C1,FCN3,H2AW,CD36 0.025874 0.437103 CXCL13,MAPK14,F2,IGHM,IL1R1,ITGA1,LBP,LEP,LGALS9,MDK,CXCL9,PDGFB,MAPK3,PRTN3,PTPN6,PTPN11,RAC1,RET,S100A9,S100A12,S MAS vs. active sJIA GO_LEUKOCYTE_MIGRATION 514 187 23 AA1,SHC1,YES1 0.027186 0.453929 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION 279 108 15 CXCL13,FGG,ICOSLG,IGFBP2,IL18,LEP,LGALS9,MDK,PRKCZ,BAD,PTPN6,PTPN11,RAC1,YES1,CD27 0.027962 0.453929 MAS vs. active sJIA GO_INTERLEUKIN_8_PRODUCTION 101 29 6 CRP,HSPA1A,LBP,LEP,LGALS9,STAT3 0.028106 0.453929 MAS vs. active sJIA GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT 112 29 6 MAPK14,HSP90AB1,LEP,PRKACA,PTPN11,CD36 0.028106 0.453929 MAS vs. active sJIA GO_REGULATION_OF_MRNA_METABOLIC_PROCESS 344 29 6 MAPK14,HSPA1A,HSPA8,YWHAB,YWHAZ,RBM39 0.028106 0.453929 MAS vs. active sJIA GO_MRNA_METABOLIC_PROCESS 887 45 8 MAPK14,HSPA1A,HSPA8,PRKACA,STAT3,YWHAB,YWHAZ,RBM39 0.028138 0.453929 NAMPT,MAPK14,ADSL,ENO1,ICOSLG,HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IGFBP2,LEP,MDK,MPO,PRKACA,MAPK3,BAD,PTPN1 MAS vs. active sJIA GO_RESPONSE_TO_ABIOTIC_STIMULUS 1237 198 24 1,HAMP,RAC1,MAP2K4,STAT1,CAT,H2AW 0.028311 0.453929 MAS vs. active sJIA GO_RESPONSE_TO_TEMPERATURE_STIMULUS 233 37 7 HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,PRKACA,MAPK3 0.028776 0.453929 MAS vs. active sJIA GO_PROTEIN_IMPORT 200 37 7 MAPK14,HSPA8,HSP90AA1,HSP90AB1,LEP,STAT3,CD36 0.028776 0.453929 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS 253 37 7 NAMPT,CTSV,HSPA8,LCN2,LEP,MAPK3,DCTPP1 0.028776 0.453929 MAS vs. active sJIA GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION 32 15 4 IL1R1,IL18,PRKCZ,TNFRSF1B 0.030155 0.45751 MAS vs. active sJIA GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION32 15 4 CRP,IL18,PLA2G2A,CD36 0.030155 0.45751 MAS vs. active sJIA GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION 53 15 4 MAPK14,IL18,CXCL9,CDON 0.030155 0.45751 MAS vs. active sJIA GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION 55 15 4 MPO,PLA2G2A,PRKACA,APOM 0.030155 0.45751 MAS vs. active sJIA GO_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION 55 15 4 HSPA1A,BAD,YWHAB,YWHAZ 0.030155 0.45751 MAS vs. active sJIA GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY45 15 4 HSPA1A,BAD,YWHAB,YWHAZ 0.030155 0.45751 MAS vs. active sJIA GO_MUSCLE_HYPERTROPHY 109 22 5 BMP10,LEP,HAMP,MAP2K4,TNFRSF1B 0.030385 0.458083 CXCL13,MAPK14,F2,FCER2,GDI2,HTRA2,HSPA1A,HSP90AA1,HSP90AB1,IL18,ITGA1,LEP,LGALS9,MMP17,PDGFA,PDGFB,POR,PRKACA,PR MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY 1469 296 33 KCZ,MAPK3,MAP2K1,PRTN3,BAD,PTPN11,RET,S100A9,S100A12,SAA1,MAP2K4,SHC1,STAT3,UBE2I,YWHAB 0.031792 0.46674 MAS vs. active sJIA GO_RESPONSE_TO_OXYGEN_RADICAL 31 9 3 MPO,PRDX1,CD36 0.032467 0.46674 MAS vs. active sJIA GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS 71 9 3 HSP90AA1,HSP90AB1,MAPK3 0.032467 0.46674 MAS vs. active sJIA GO_GOLGI_ORGANIZATION 151 9 3 MAPK3,MAP2K1,YWHAZ 0.032467 0.46674 MAS vs. active sJIA GO_REGULATION_OF_B_CELL_DIFFERENTIATION 29 9 3 BAD,PTPN6,CD27 0.032467 0.46674 MAS vs. active sJIA GO_FACE_DEVELOPMENT 48 9 3 MAPK3,MAP2K1,PTPN11 0.032467 0.46674 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL 28 9 3 MPO,PRDX1,CD36 0.032467 0.46674 MAS vs. active sJIA GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS 155 30 6 ENO1,GPI,PGAM1,BAD,STAT3,TPI1 0.03282 0.46674 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_COAGULATION 55 30 6 F2,FAP,FGG,HRG,PDGFA,PDGFB 0.03282 0.46674 MAS vs. active sJIA GO_MAINTENANCE_OF_LOCATION_IN_CELL 216 38 7 F2,FTH1,LCN2,CXCL9,PRKACA,PTPN6,S100A9 0.032919 0.46674 NAMPT,MAPK14,FAP,HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,LEP,MCL1,PGAM1,PRKACA,MAPK3,BAD,STAT3,TNFRSF1B,YWHAB,Y MAS vs. active sJIA GO_REGULATION_OF_CATABOLIC_PROCESS 1030 140 18 WHAZ 0.033876 0.477473 MAPK14,GRK2,FCGR3B,FGG,FTH1,GDI2,GPI,HRG,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,LCN2,LEP,LGALS9,MPO,PDGFA,PDGFB,PGAM1,S MAS vs. active sJIA GO_SECRETION 1618 331 36 ERPINA4,PLA2G2A,PRSS2,PRTN3,BAD,PTPN6,PTPN11,RAC1,S100A9,S100A12,SAA1,STAT3,TNFRSF1B,VWF,CAT,IL1RL1,CD36 0.034884 0.485181 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS1567 121 16 MAPK14,ENO1,HSPA1A,HSPA8,LEP,PDGFB,HAMP,SHC1,STAT1,STAT3,UBE2I,YWHAB,H3C1,FCN3,H2AW,CD36 0.035643 0.485181 MAS vs. active sJIA GO_RESPONSE_TO_RETINOIC_ACID 108 23 5 HTRA2,IGFBP2,LEP,RET,YES1 0.036324 0.485181 MAS vs. active sJIA GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN 71 23 5 CXCL13,HRG,PTPN6,PTPN11,RET 0.036324 0.485181 MAS vs. active sJIA GO_ERYTHROCYTE_HOMEOSTASIS 129 23 5 MAPK14,HSPA1A,PRDX1,STAT1,STAT3 0.036324 0.485181 MAS vs. active sJIA GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS 208 23 5 MAPK14,HSPA1A,HSPA8,YWHAB,YWHAZ 0.036324 0.485181 MAS vs. active sJIA GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY 331 102 14 MAPK14,IL18,ITGA1,LEP,PDGFB,PRKACA,PRKCZ,MAPK3,MAP2K1,PTPN11,RET,SAA1,MAP2K4,SHC1 0.036654 0.485181 MAS vs. active sJIA GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY 154 56 9 FCER2,IL1R1,IL18,LAG3,LEP,LGALS9,PRKCZ,PTPN6,TNFRSF1B 0.037068 0.485181 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS 330 56 9 NAMPT,MAPK14,MAPK3,BAD,PTPN11,HAMP,RAC1,MAP2K4,H2AW 0.037068 0.485181 MAS vs. active sJIA GO_GRANULOCYTE_CHEMOTAXIS 126 74 11 CXCL13,MAPK14,ITGA1,LBP,MDK,CXCL9,MAPK3,RAC1,S100A9,S100A12,SAA1 0.037162 0.485181 MAS vs. active sJIA GO_PLACENTA_DEVELOPMENT 156 39 7 MAPK14,CTSV,HSP90AB1,LEP,PDGFB,MAPK3,MAP2K1 0.037445 0.485181 MAS vs. active sJIA GO_TELOMERE_ORGANIZATION 174 16 4 HSP90AA1,HSP90AB1,MAPK3,H3C1 0.037694 0.485181 MAS vs. active sJIA GO_PROTEIN_INSERTION_INTO_MEMBRANE 65 16 4 HSP90AA1,BAD,YWHAB,YWHAZ 0.037694 0.485181 MAS vs. active sJIA GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS66 16 4 HSPA1A,BAD,YWHAB,YWHAZ 0.037694 0.485181 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MEMBRANE_PERMEABILITY 67 16 4 HSPA1A,BAD,YWHAB,YWHAZ 0.037694 0.485181 MAS vs. active sJIA GO_RNA_CATABOLIC_PROCESS 415 31 6 MAPK14,HSPA1A,HSPA8,TNFRSF1B,YWHAB,YWHAZ 0.038023 0.485181 MAS vs. active sJIA GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND 75 31 6 HTRA2,HSPA1A,LCN2,MCL1,BAD,RET 0.038023 0.485181 MAS vs. active sJIA GO_LYMPHOCYTE_MEDIATED_IMMUNITY 359 93 13 CRP,FCER2,IGHM,IL1R1,IL18,LAG3,LEP,LGALS9,PRDX1,PRKCZ,PTPN6,TNFRSF1B,CD27 0.038195 0.485181 MAS vs. active sJIA GO_WOUND_HEALING 536 152 19 F2,FAP,FGG,HGFAC,HRG,CLEC1B,PDGFA,PDGFB,PRKACA,MAPK3,PRTN3,PTPN6,PTPN11,RAC1,SAA1,VWF,YWHAZ,H3C1,CD36 0.038325 0.485181 MAS vs. active sJIA GO_CELLULAR_HOMEOSTASIS 971 142 18 CXCL13,F2,FTH1,LCN2,MCL1,CXCL9,MPO,PRDX1,PRKACA,MAPK3,BAD,PTPN6,HAMP,RAC1,S100A9,SAA1,TPT1,CD36 0.038497 0.485181 MAS vs. active sJIA GO_CHEMICAL_HOMEOSTASIS 1213 173 21 CXCL13,F2,FTH1,IL18,LCN2,LEP,CXCL9,PRKACA,APOM,MAPK3,BAD,PTPN6,PTPN11,HAMP,RAC1,S100A9,SAA1,STAT1,STAT3,TPT1,CD36 0.039694 0.496886 MAS vs. active sJIA GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS 774 133 17 NAMPT,ENO1,HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,LEP,MCL1,PRDX1,MAPK3,MAP2K1,BAD,MAP2K4,TPT1,CD27,CD36 0.041029 0.496886 MAS vs. active sJIA GO_CELLULAR_MACROMOLECULE_CATABOLIC_PROCESS 1201 94 13 MAPK14,CTSV,FAP,HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,PRKACA,TNFRSF1B,UBE2I,YWHAB,YWHAZ 0.041262 0.496886 MAS vs. active sJIA GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS 725 94 13 AKR1A1,ENO1,GPI,LEP,MDH1,MPO,PDGFB,PGAM1,POR,ASAH2,TKT,TPI1,DCTPP1 0.041262 0.496886 MAS vs. active sJIA GO_PHAGOCYTOSIS 375 85 12 CRP,HSP90AA1,HSP90AB1,IGHM,LBP,LEP,MAPK3,PRTN3,RAC1,YES1,FCN3,CD36 0.04286 0.496886 MAS vs. active sJIA GO_DIGESTION 141 24 5 LEP,PRSS2,ASAH2,HAMP,CD36 0.042933 0.496886 MAS vs. active sJIA GO_RESPONSE_TO_STARVATION 206 24 5 CTSV,ADSL,HSPA8,MAPK3,HAMP 0.042933 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION 20 10 3 IL1R1,IL18,PRKCZ 0.043629 0.496886 MAS vs. active sJIA GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS 63 10 3 AKR1A1,TKT,TPI1 0.043629 0.496886 MAS vs. active sJIA GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING 81 10 3 HSP90AA1,HSP90AB1,MAPK3 0.043629 0.496886 MAS vs. active sJIA GO_P38MAPK_CASCADE 52 10 3 MAPK14,LEP,LGALS9 0.043629 0.496886 MAS vs. active sJIA GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS 32 10 3 MPO,PRDX1,CAT 0.043629 0.496886 MAS vs. active sJIA GO_REGULATION_OF_FIBRINOLYSIS 14 10 3 F2,FAP,HRG 0.043629 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY 36 10 3 HSP90AA1,HSP90AB1,MAPK3 0.043629 0.496886 MAS vs. active sJIA GO_INTERLEUKIN_6_MEDIATED_SIGNALING_PATHWAY 34 10 3 PTPN11,STAT1,STAT3 0.043629 0.496886 MAS vs. active sJIA GO_RNA_PROCESSING 1442 32 6 HSPA1A,HSPA8,PRKACA,MAP2K1,STAT3,RBM39 0.043727 0.496886 MAS vs. active sJIA GO_SMALL_MOLECULE_CATABOLIC_PROCESS 452 49 8 AKR1A1,ENO1,GPI,LEP,PGAM1,NAGK,BAD,TPI1 0.044537 0.496886 MAS vs. active sJIA GO_MUSCLE_SYSTEM_PROCESS 467 58 9 GRK2,ENO1,BMP10,ITGA1,LEP,PRKACA,HAMP,MAP2K4,TNFRSF1B 0.045272 0.496886 MAS vs. active sJIA GO_NEUTROPHIL_CHEMOTAXIS 102 58 9 CXCL13,ITGA1,LBP,MDK,CXCL9,RAC1,S100A9,S100A12,SAA1 0.045272 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION 55 17 4 HRG,PRKCZ,RAC1,CD36 0.046221 0.496886 MAS vs. active sJIA GO_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE70 17 4 MAPK14,F2,LEP,STAT3 0.046221 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE55 17 4 IL1R1,IL18,PRKCZ,CD36 0.046221 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION73 17 4 MAPK14,BMP10,CXCL9,HAMP 0.046221 0.496886 MAS vs. active sJIA GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL81 17 4 F2,CXCL9,PRKACA,PTPN6 0.046221 0.496886 MAS vs. active sJIA GO_REGULATION_OF_KIDNEY_DEVELOPMENT 56 17 4 PDGFA,PDGFB,RET,STAT1 0.046221 0.496886 MAS vs. active sJIA GO_REGULATION_OF_COAGULATION 88 41 7 F2,FAP,FGG,HRG,PDGFA,PDGFB,CD36 0.04769 0.496886 CRP,GRK2,F2,HRG,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,LGALS9,MRC1,CLEC1B,MAPK3,BAD,RAC1,SHC1,STAT1,STAT3,UBE2I,YWHAB,F MAS vs. active sJIA GO_SYMBIOTIC_PROCESS 980 166 20 CN3 0.047789 0.496886 MAS vs. active sJIA GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS620 68 10 NAMPT,ADSL,ENO1,GPI,PGAM1,NAGK,BAD,STAT3,TPI1,DCTPP1 0.049209 0.496886 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_LIPID 588 126 16 CXCL13,MAPK14,HTRA2,IL18,LBP,LCN2,LEP,CXCL9,MRC1,MAPK3,BAD,HAMP,RET,TNFRSF1B,YES1,CD36 0.049617 0.496886 MAS vs. active sJIA GO_ACTIVATION_OF_MAPK_ACTIVITY 156 59 9 MAPK14,ITGA1,MAPK3,MAP2K1,PTPN11,RET,SAA1,MAP2K4,SHC1 0.049801 0.496886 MAS vs. active sJIA GO_FATTY_ACID_METABOLIC_PROCESS 396 33 6 MAPK14,LEP,POR,MAPK3,ASAH2,CD36 0.049944 0.496886 MAS vs. active sJIA GO_RESPONSE_TO_ETHANOL 122 33 6 LEP,BAD,HAMP,STAT3,CAT,CD27 0.049944 0.496886 CXCL13,MAPK14,FCER2,FGG,HTRA2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IL1R1,IL18,LBP,LCN2,LEP,LGALS9,MCL1,CXCL9,MRC1,PDGF B,PRKACA,MAPK3,PRTN3,ASAH2,BAD,PTPN6,PTPN11,HAMP,SAA1,SHC1,STAT1,STAT3,THPO,TNFRSF1B,YWHAZ,H3C1,IL1RL1,CD27,CD3 MAS vs. active sJIA GO_RESPONSE_TO_CYTOKINE 1225 362 38 6 0.05017 0.496886 MAS vs. active sJIA GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE103 25 5 HTRA2,MCL1,BAD,TNFRSF1B,TPT1 0.050223 0.496886 MAS vs. active sJIA GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY 59 25 5 MAPK14,IL18,LBP,MAPK3,CD36 0.050223 0.496886 MAS vs. active sJIA GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS 105 25 5 MPO,PLA2G2A,PRKACA,APOM,CD36 0.050223 0.496886 F2,FAP,FGG,HGFAC,HRG,MDK,CLEC1B,PDGFA,PDGFB,PRKACA,MAPK3,MAP2K1,PRTN3,PTPN6,PTPN11,RAC1,SAA1,MAP2K4,VWF,YWHA MAS vs. active sJIA GO_RESPONSE_TO_WOUNDING 656 188 22 Z,H3C1,CD36 0.050998 0.496886 MAS vs. active sJIA GO_CELLULAR_LIPID_METABOLIC_PROCESS 1098 97 13 MAPK14,HTRA2,LEP,PDGFA,PDGFB,PLA2G2A,POR,APOM,MAPK3,ASAH2,PTPN11,CAT,CD36 0.051511 0.496886 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 222 78 11 CXCL13,MAPK14,IL18,LBP,LCN2,CXCL9,MRC1,MAPK3,HAMP,TNFRSF1B,CD36 0.052048 0.496886 CRP,MAPK14,F2,ICOSLG,HSPA1A,HSP90AB1,IL1R1,IL18,LBP,LEP,LGALS9,MDK,PRKCZ,PTPN6,PTPN11,RAC1,S100A9,S100A12,SAA1,STAT1 MAS vs. active sJIA GO_CYTOKINE_PRODUCTION 880 210 24 ,STAT3,TNFRSF1B,IL1RL1,CD36 0.053348 0.496886 MAS vs. active sJIA GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION 1193 69 10 MAPK14,HSPA1A,HSPA8,MAPK3,MAP2K1,STAT3,TNFRSF1B,YWHAB,YWHAZ,H3C1 0.053626 0.496886 MAS vs. active sJIA GO_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY 448 69 10 CXCL13,HRG,HSPA1A,HSPA8,HSP90AA1,PRKCZ,PTPN11,RAC1,CAPG,CD36 0.053626 0.496886 NAMPT,CXCL13,GNLY,CRP,MAPK14,F2,ICOSLG,HRG,HSP90AB1,IGHM,IL1R1,IL18,LAG3,LBP,LCN2,LEP,LGALS9,MDK,CXCL9,MPO,MRC1,P RDX1,CLEC1B,PI3,PLA2G2A,PRKACA,PRKCZ,MAPK3,PTPN6,PTPN11,HAMP,RAC1,S100A9,S100A12,SAA1,SHC1,STAT1,STAT3,TNFRSF1B,Y MAS vs. active sJIA GO_DEFENSE_RESPONSE 1814 432 44 ES1,H2BC21,FCN3,IL1RL1,CD36 0.053662 0.496886 CXCL13,CRP,MAPK14,F2,FCER2,FCGR3B,ICOSLG,GPI,HRG,HSPA1A,HSP90AA1,HSP90AB1,IGFBP2,IGHM,IL1R1,IL18,LAG3,LBP,LEP,LGALS9, MDK,PLA2G2A,PRKACA,PRKCZ,MAPK3,BAD,PTPN6,PTPN11,RAC1,MAP2K4,SHC1,STAT1,STAT3,THPO,TNFRSF1B,YES1,H3C1,FCN3,IL1RL1 MAS vs. active sJIA GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS 1637 398 41 ,CD27,CD36 0.054301 0.496886 MAS vs. active sJIA GO_INTERLEUKIN_6_PRODUCTION 170 51 8 IL18,LBP,LEP,LGALS9,PTPN6,PTPN11,STAT3,CD36 0.05472 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION 235 98 13 ICOSLG,IGFBP2,IL18,LEP,LGALS9,MDK,PRKCZ,BAD,PTPN6,PTPN11,RAC1,YES1,CD27 0.05529 0.496886 MAS vs. active sJIA GO_CYTOLYSIS 29 18 4 F2,HRG,LBP,PLA2G2A 0.055735 0.496886 MAS vs. active sJIA GO_RESPONSE_TO_TYPE_I_INTERFERON 99 18 4 HSP90AB1,PTPN6,PTPN11,STAT1 0.055735 0.496886 MAS vs. active sJIA GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS 116 18 4 FTH1,LCN2,HAMP,S100A9 0.055735 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION58 18 4 HTRA2,BAD,YWHAB,YWHAZ 0.055735 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS 69 18 4 HSP90AA1,HSP90AB1,PDGFB,MAPK3 0.055735 0.496886 MAS vs. active sJIA GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY 220 11 3 H2BC21,H3C1,H2AW 0.056444 0.496886 MAS vs. active sJIA GO_MYOBLAST_FUSION 45 11 3 MAPK14,CXCL9,CDON 0.056444 0.496886 MAS vs. active sJIA GO_REGULATION_OF_LIPID_STORAGE 52 11 3 CRP,LEP,CD36 0.056444 0.496886 MAS vs. active sJIA GO_LIPID_OXIDATION 111 11 3 MAPK14,LEP,POR 0.056444 0.496886 MAS vs. active sJIA GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING 119 11 3 MAP2K1,STAT3,H3C1 0.056444 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT 32 11 3 BMP10,MDK,PO R 0.056444 0.496886 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION 68 11 3 NAMPT,MAPK14,HAMP 0.056444 0.496886 MAS vs. active sJIA GO_BONE_CELL_DEVELOPMENT 35 11 3 PTPN6,PTPN11,THPO 0.056444 0.496886 MAS vs. active sJIA GO_ASTROCYTE_DIFFERENTIATION 83 34 6 F2,MAPK3,MAP2K1,PTPN11,S100A9,STAT3 0.05668 0.496886 MAS vs. active sJIA GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS 128 34 6 HSP90AA1,HSP90AB1,MPO,RAC1,STAT3,CD36 0.05668 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION94 34 6 LBP,LEP,LGALS9,PTPN11,STAT3,CD36 0.05668 0.496886 MAPK14,ENO1,F2,BMP10,HTRA2,HRG,HSPA1A,HSP90AA1,HSP90AB1,IGFBP2,LEP,MDK,POR,PRKCZ,PRSS2,PTPN11,HAMP,S100A9,MAP2K MAS vs. active sJIA GO_GROWTH 983 201 23 4,SHC1,STAT3,TKT,NTN1 0.057722 0.496886 MAS vs. active sJIA GO_NATURAL_KILLER_CELL_PROLIFERATION 11 5 2 IL18,LEP 0.058068 0.496886 MAS vs. active sJIA GO_DE_NOVO_PROTEIN_FOLDING 41 5 2 HSPA1A,HSPA8 0.058068 0.496886 MAS vs. active sJIA GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY 38 5 2 HRG,RAC1 0.058068 0.496886 MAS vs. active sJIA GO_ALDITOL_METABOLIC_PROCESS 25 5 2 LEP,TPI1 0.058068 0.496886 MAS vs. active sJIA GO_CEREBELLAR_CORTEX_FORMATION 24 5 2 MAP2K1,PTPN11 0.058068 0.496886 MAS vs. active sJIA GO_REGULATION_OF_NUCLEOTIDE_BIOSYNTHETIC_PROCESS 42 5 2 ENO1,STAT3 0.058068 0.496886 MAS vs. active sJIA GO_RESPONSE_TO_FOOD 38 5 2 LEP,MPO 0.058068 0.496886 MAS vs. active sJIA GO_RESPONSE_TO_VITAMIN_A 19 5 2 HAMP,CAT 0.058068 0.496886 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN12 5 2 HRG,PTPN11 0.058068 0.496886 MAS vs. active sJIA GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY 16 5 2 PRKACA,APOM 0.058068 0.496886 MAS vs. active sJIA GO_HIPPO_SIGNALING 44 5 2 MAPK14,YWHAB 0.058068 0.496886 MAS vs. active sJIA GO_RESPONSE_TO_INTERFERON_BETA 31 5 2 HTRA2,STAT1 0.058068 0.496886 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA 22 5 2 HTRA2,STAT1 0.058068 0.496886 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS 19 5 2 LEP,STAT3 0.058068 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION 13 5 2 BAD,CD27 0.058068 0.496886 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION 7 5 2 LAG3,MDK 0.058068 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION 7 5 2 IL18,PRKCZ 0.058068 0.496886 MAS vs. active sJIA GO_ALDEHYDE_BIOSYNTHETIC_PROCESS 15 5 2 TKT,TPI1 0.058068 0.496886 MAS vs. active sJIA GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT26 5 2 PDGFB,STAT1 0.058068 0.496886 MAS vs. active sJIA GO_METANEPHRIC_GLOMERULUS_DEVELOPMENT 16 5 2 PDGFB,RET 0.058068 0.496886 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_GLOMERULUS_DEVELOPMENT 11 5 2 PDGFB,RET 0.058068 0.496886 MAS vs. active sJIA GO_INTESTINAL_LIPID_ABSORPTION 19 5 2 LEP,CD36 0.058068 0.496886 MAS vs. active sJIA GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION 37 5 2 GRK2,STAT3 0.058068 0.496886 MAS vs. active sJIA GO_REGULATION_OF_INTESTINAL_ABSORPTION 11 5 2 LEP,HAMP 0.058068 0.496886 MAS vs. active sJIA GO_REGULATION_OF_T_HELPER_1_CELL_CYTOKINE_PRODUCTION 5 5 2 IL1R1,IL18 0.058068 0.496886 MAS vs. active sJIA GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS 52 26 5 MAPK14,LBP,MDK,MAPK3,RAC1 0.058199 0.496886 MAS vs. active sJIA GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS 87 26 5 HSP90AA1,HSP90AB1,POR,RAC1,CD36 0.058199 0.496886 MAS vs. active sJIA GO_PROTEIN_LOCALIZATION_TO_NUCLEUS 277 43 7 MAPK14,F2,HSP90AB1,LEP,SUMO3,STAT3,CD36 0.059582 0.505066 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING 93 43 7 F2,FAP,FGG,HRG,MDK,PDGFA,PDGFB 0.059582 0.505066 MAS vs. active sJIA GO_REGULATION_OF_AUTOPHAGY 347 52 8 NAMPT,HTRA2,LEP,MCL1,PRKACA,MAPK3,BAD,STAT3 0.060331 0.509605 CXCL13,MAPK14,CTSV,HTRA2,IGFBP2,IL18,LBP,LCN2,LEP,LGALS9,MDK,CXCL9,MPO,MRC1,MAPK3,BAD,HAMP,RET,S100A9,STAT3,TNFR MAS vs. active sJIA GO_RESPONSE_TO_LIPID 909 213 24 SF1B,YES1,CAT,CD36 0.061591 0.516587 MAPK14,FGG,ITGA1,LEP,LGALS9,PRDX1,CDON,PDGFA,PDGFB,PLA2G2A,PRKCZ,MAPK3,MAP2K1,PTPN6,PTPN11,RET,S100A12,SAA1,MA MAS vs. active sJIA GO_REGULATION_OF_MAPK_CASCADE 751 213 24 P2K4,SHC1,THPO,YWHAZ,CD27,CD36 0.061591 0.516587 MAS vs. active sJIA GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS363 90 12 CXCL13,CRP,FCER2,IGHM,IL1R1,IL18,PRKCZ,PTPN6,STAT3,TNFRSF1B,IL1RL1,CD27 0.062472 0.520308 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY 264 90 12 MAPK14,ITGA1,PDGFA,PDGFB,MAPK3,MAP2K1,PTPN11,RET,S100A12,SAA1,MAP2K4,SHC1 0.062472 0.520308 MAS vs. active sJIA GO_CELLULAR_ION_HOMEOSTASIS 679 100 13 CXCL13,F2,FTH1,LCN2,CXCL9,PRKACA,MAPK3,PTPN6,HAMP,S100A9,SAA1,TPT1,CD36 0.06341 0.522198 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY345 100 13 MAPK14,HSP90AB1,ITGA1,PDGFA,PDGFB,MAPK3,MAP2K1,PTPN11,RET,S100A12,SAA1,MAP2K4,SHC1 0.06341 0.522198 CXCL13,MAPK14,F2,FTH1,HSPA1A,HSP90AA1,HSP90AB1,IL18,LCN2,LEP,LGALS9,MCL1,CXCL9,MPO,PRDX1,PLA2G2A,PRKACA,APOM, MAS vs. active sJIA GO_HOMEOSTATIC_PROCESS 1963 279 30 MAPK3,BAD,PTPN6,PTPN11,HAMP,RAC1,S100A9,SAA1,STAT1,STAT3,TPT1,CD36 0.064043 0.522198 CRP,F2,FCER2,ICOSLG,HRG,HSP90AA1,HSP90AB1,IGHM,IL1R1,IL18,LAG3,LBP,LGALS9,PRKACA,PRKCZ,MAPK3,PTPN6,RAC1,YES1,FCN3,C MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE 763 182 21 D36 0.064144 0.522198 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS 246 81 11 CXCL13,MAPK14,IL18,LBP,LCN2,CXCL9,MRC1,MAPK3,HAMP,TNFRSF1B,CD36 0.065575 0.522198 MAS vs. active sJIA GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY 108 44 7 F2,IL18,LAG3,LEP,LGALS9,PRDX1,PTPN6 0.06616 0.522198 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS 264 44 7 NAMPT,MAPK14,HTRA2,HSP90AB1,LEP,MCL1,STAT3 0.06616 0.522198 MAS vs. active sJIA GO_METANEPHROS_DEVELOPMENT 91 19 4 PDGFA,PDGFB,RET,STAT1 0.066226 0.522198 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION 35 19 4 MAPK14,LGALS9,MDK,CD36 0.066226 0.522198 MAS vs. active sJIA GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY 66 19 4 FCER2,HSP90AA1,LEP,POR 0.066226 0.522198 MAS vs. active sJIA GO_FIBRINOLYSIS 26 19 4 F2,FAP,FGG,HRG 0.066226 0.522198 MAS vs. active sJIA GO_TRANSITION_METAL_ION_HOMEOSTASIS 138 19 4 FTH1,LCN2,HAMP,S100A9 0.066226 0.522198 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_COLD_INDUCED_THERMOGENESIS 97 19 4 IL18,LCN2,LEP,CD36 0.066226 0.522198 MAS vs. active sJIA GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND48 19 4 HTRA2,HSPA1A,MCL1,RET 0.066226 0.522198 MAS vs. active sJIA GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING 127 53 8 F2,IL18,LEP,PDGFA,PDGFB,MAPK3,PTPN6,CAT 0.066295 0.522198 MAS vs. active sJIA GO_FC_RECEPTOR_MEDIATED_STIMULATORY_SIGNALING_PATHWAY 144 27 5 HSP90AA1,HSP90AB1,MAPK3,RAC1,YES1 0.066864 0.522198 MAS vs. active sJIA GO_INTERLEUKIN_12_PRODUCTION 57 27 5 MAPK14,LEP,LGALS9,MDK,CD36 0.066864 0.522198 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION 131 27 5 FGG,LEP,BAD,PTPN11,RAC1 0.066864 0.522198 MAS vs. active sJIA GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION 144 27 5 HTRA2,HSP90AA1,BAD,YWHAB,YWHAZ 0.066864 0.522198 MAS vs. active sJIA GO_REGULATION_OF_T_CELL_ACTIVATION 332 121 15 ICOSLG,IGFBP2,IL18,LAG3,LEP,LGALS9,MDK,PRKCZ,BAD,PTPN6,PTPN11,RAC1,TNFRSF1B,YES1,CD27 0.067713 0.527097 MAS vs. active sJIA GO_MYELOID_LEUKOCYTE_MIGRATION 221 111 14 CXCL13,MAPK14,IL1R1,ITGA1,LBP,MDK,CXCL9,PDGFB,MAPK3,PRTN3,RAC1,S100A9,S100A12,SAA1 0.067953 0.527244 MAS vs. active sJIA GO_PHAGOCYTOSIS_RECOGNITION 81 12 3 IGHM,FCN3,CD36 0.07083 0.530807 MAS vs. active sJIA GO_RNA_SPLICING 484 12 3 HSPA1A,HSPA8,RBM39 0.07083 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION19 12 3 IL18,PLA2G2A,CD36 0.07083 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS 19 12 3 MAPK14,MDK,MAPK3 0.07083 0.530807 MAS vs. active sJIA GO_INTERLEUKIN_13_PRODUCTION 21 12 3 IL18,LGALS9,PRKCZ 0.07083 0.530807 MAS vs. active sJIA GO_PROTEIN_CONTAINING_COMPLEX_REMODELING 32 12 3 MPO,PLA2G2A,APOM 0.07083 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_COAGULATION 29 12 3 F2,HRG,CD36 0.07083 0.530807 MAS vs. active sJIA GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY 52 12 3 FCER2,HSP90AA1,LEP 0.07083 0.530807 MAS vs. active sJIA GO_REGULATION_OF_TELOMERASE_ACTIVITY 48 12 3 HSP90AA1,HSP90AB1,MAPK3 0.07083 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION 122 36 6 FGG,HRG,MDK,PRKCZ,RAC1,CD36 0.071729 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE 214 92 12 FGG,LGALS9,PDGFA,PDGFB,PLA2G2A,PRKCZ,MAPK3,MAP2K1,PTPN11,SHC1,THPO,CD36 0.071774 0.530807 CXCL13,FCER2,HSPA1A,HSPA8,HSP90AA1,HSP90AB1,IL1R1,IL18,LBP,LCN2,LEP,MCL1,CXCL9,PDGFB,PRKACA,MAPK3,PRTN3,BAD,PTPN6, MAS vs. active sJIA GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY 807 293 31 PTPN11,SAA1,SHC1,STAT1,STAT3,THPO,TNFRSF1B,YWHAZ,H3C1,IL1RL1,CD27,CD36 0.07219 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY 183 54 8 HTRA2,LGALS9,MCL1,BAD,RET,S100A9,YWHAB,YWHAZ 0.072616 0.530807 MAS vs. active sJIA GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 166 45 7 ENO1,HTRA2,HSPA1A,MCL1,BAD,S100A9,TPT1 0.073164 0.530807 MAS vs. active sJIA GO_NUCLEOTIDE_PHOSPHORYLATION 135 28 5 ENO1,GPI,PGAM1,STAT3,TPI1 0.076212 0.530807 MAS vs. active sJIA GO_CIRCULATORY_SYSTEM_PROCESS 576 93 12 NAMPT,CRP,GRK2,FGG,BMP10,ITGA1,LEP,PDGFB,PRKACA,STAT1,YES1,CD36 0.076748 0.530807 MAS vs. active sJIA GO_T_CELL_CYTOKINE_PRODUCTION 43 20 4 IL1R1,IL18,PRKCZ,TNFRSF1B 0.07767 0.530807 MAS vs. active sJIA GO_SUPEROXIDE_METABOLIC_PROCESS 74 20 4 CRP,MPO,PRDX1,CD36 0.07767 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION 54 20 4 HSPA1A,LBP,LGALS9,STAT3 0.07767 0.530807 MAS vs. active sJIA GO_RIBOSE_PHOSPHATE_BIOSYNTHETIC_PROCESS 194 20 4 ADSL,ENO1,STAT3,TKT 0.07767 0.530807 MAS vs. active sJIA GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION73 20 4 HTRA2,BAD,YWHAB,YWHAZ 0.07767 0.530807 MAPK14,FGG,BMP10,HSPA1A,HSP90AB1,IL18,LGALS9,MDK,CXCL9,CDON,PLA2G2A,POR,PRKCZ,MAP2K1,BAD,HAMP,RAC1,RET,S100A9, MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION 1033 240 26 STAT1,STAT3,THPO,TNFRSF1B,CD27,NTN1,CD36 0.078296 0.530807 MAS vs. active sJIA GO_RIBOSE_PHOSPHATE_METABOLIC_PROCESS 427 55 8 ADSL,ENO1,GPI,PGAM1,BAD,STAT3,TKT,TPI1 0.079295 0.530807 MAS vs. active sJIA GO_PROTEIN_TARGETING 441 37 6 HTRA2,HSPA8,HSP90AA1,YWHAB,YWHAZ,CAT 0.080043 0.530807 MAPK14,HSP90AA1,HSP90AB1,IL18,ITGA1,LEP,PDGFA,PDGFB,PRKACA,PRKCZ,MAPK3,MAP2K1,PTPN11,RET,S100A12,SAA1,MAP2K4,SHC MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_ACTIVITY 539 155 18 1 0.080428 0.530807 MAS vs. active sJIA GO_RESPONSE_TO_NUTRIENT 171 46 7 ADSL,IGFBP2,LEP,POR,HAMP,STAT1,CAT 0.080595 0.530807 MAS vs. active sJIA GO_NUCLEAR_TRANSPORT 357 46 7 MAPK14,HSP90AB1,LEP,PRKACA,PTPN11,STAT3,CD36 0.080595 0.530807 MAPK14,FGG,ITGA1,LEP,LGALS9,CDON,PDGFA,PDGFB,PLA2G2A,PRKCZ,MAPK3,MAP2K1,PTPN11,RET,S100A12,SAA1,MAP2K4,SHC1,TH MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MAPK_CASCADE 553 187 21 PO,CD27,CD36 0.081611 0.530807 MAS vs. active sJIA GO_RESPIRATORY_BURST_INVOLVED_IN_DEFENSE_RESPONSE 13 6 2 LBP,MPO 0.082451 0.530807 MAS vs. active sJIA GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN12 6 2 FCER2,PTPN6 0.082451 0.530807 MAS vs. active sJIA GO_PHYSIOLOGICAL_CARDIAC_MUSCLE_HYPERTROPHY 38 6 2 HAMP,MAP2K4 0.082451 0.530807 MAS vs. active sJIA GO_OPSONIZATION 13 6 2 CRP,LBP 0.082451 0.530807 MAS vs. active sJIA GO_MULTICELLULAR_ORGANISM_AGING 35 6 2 CTSV,LEP 0.082451 0.530807 MAS vs. active sJIA GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS 21 6 2 RAC1,STAT3 0.082451 0.530807 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE 22 6 2 CRP,LEP 0.082451 0.530807 MAS vs. active sJIA GO_PROTEIN_SUMOYLATION 82 6 2 SUMO3,UBE2I 0.082451 0.530807 MAS vs. active sJIA GO_CEREBELLAR_CORTEX_MORPHOGENESIS 33 6 2 MAP2K1,PTPN11 0.082451 0.530807 MAS vs. active sJIA GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS 36 6 2 HSP90AA1,HSP90AB1 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION34 6 2 HSPA1A,RAC1 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY21 6 2 HSP90AB1,ITGA1 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION 12 6 2 LGALS9,PRKCZ 0.082451 0.530807 MAS vs. active sJIA GO_INTERLEUKIN_18_MEDIATED_SIGNALING_PATHWAY 8 6 2 IL18,PDGFB 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS34 6 2 BAD,RAC1 0.082451 0.530807 MAS vs. active sJIA GO_EATING_BEHAVIOR 33 6 2 LEP,STAT3 0.082451 0.530807 MAS vs. active sJIA GO_RESPONSE_TO_LEPTIN 24 6 2 LEP,STAT3 0.082451 0.530807 MAS vs. active sJIA GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME 113 6 2 HSPA8,RBM39 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION 23 6 2 MDK,TNFRSF1B 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_KILLING_OF_CELLS_OF_OTHER_ORGANISM11 6 2 FCER2,BAD 0.082451 0.530807 MAS vs. active sJIA GO_TRACHEA_MORPHOGENESIS 11 6 2 MAPK3,MAP2K1 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY37 6 2 HSPA1A,LBP 0.082451 0.530807 MAS vs. active sJIA GO_RESPONSE_TO_INTERLEUKIN_15 14 6 2 SHC1,STAT3 0.082451 0.530807 MAS vs. active sJIA GO_RESPONSE_TO_INTERLEUKIN_18 11 6 2 IL18,PDGFB 0.082451 0.530807 MAS vs. active sJIA GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT 15 6 2 PDGFB,RET 0.082451 0.530807 MAS vs. active sJIA GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION 24 6 2 MAPK14,LEP 0.082451 0.530807 MAS vs. active sJIA GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS42 6 2 MAPK3,MAP2K1 0.082451 0.530807 MAS vs. active sJIA GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION 50 6 2 HRG,RAC1 0.082451 0.530807 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION14 6 2 FAP,TNFRSF1B 0.082451 0.530807 MAS vs. active sJIA GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT18 6 2 MAPK3,MAP2K1 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY11 6 2 HTRA2,LGALS9 0.082451 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION 337 65 9 MAPK14,F2,HTRA2,HSP90AB1,LEP,PRKACA,BAD,YWHAB,YWHAZ 0.08326 0.530807 CXCL13,MAPK14,F2,FCER2,GDI2,HTRA2,HSPA1A,HSP90AA1,HSP90AB1,IL18,ITGA1,LEP,LGALS9,MMP17,PDGFA,PDGFB,POR,PRKACA,PR MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION 1823 342 35 KCZ,MAPK3,MAP2K1,PRTN3,BAD,PTPN11,RET,S100A9,S100A12,SAA1,MAP2K4,SHC1,STAT3,UBE2I,YWHAB,CAT,CD36 0.08462 0.530807 MAS vs. active sJIA GO_MYELOID_CELL_HOMEOSTASIS 154 29 5 MAPK14,HSPA1A,PRDX1,STAT1,STAT3 0.086234 0.530807 MAS vs. active sJIA GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM 99 29 5 CRP,LBP,PLA2G2A,H2BC21,CD36 0.086234 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION 111 29 5 MAPK14,BMP10,CXCL9,CDON,HAMP 0.086234 0.530807 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS 79 29 5 MAPK3,BAD,PTPN11,RAC1,MAP2K4 0.086234 0.530807 MAS vs. active sJIA GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS 145 29 5 LEP,PRKACA,BAD,RAC1,MAP2K4 0.086234 0.530807 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY98 29 5 ENO1,HTRA2,HSPA1A,MCL1,TPT1 0.086234 0.530807 MAS vs. active sJIA GO_CELLULAR_NITROGEN_COMPOUND_CATABOLIC_PROCESS 603 56 8 MAPK14,HSPA1A,HSPA8,POR,TNFRSF1B,YWHAB,YWHAZ,DCTPP1 0.086333 0.530807 MAS vs. active sJIA GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS 256 56 8 MAPK14,HSPA1A,LGALS9,PRDX1,PLA2G2A,PTPN11,STAT1,STAT3 0.086333 0.530807 MAS vs. active sJIA GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS 673 56 8 AKR1A1,ADSL,ENO1,PDGFB,NAGK,STAT3,TKT,TPI1 0.086333 0.530807 MAS vs. active sJIA GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN 356 115 14 CXCL13,MAPK14,IL18,LBP,LCN2,LGALS9,CXCL9,MPO,MRC1,MAPK3,HAMP,S100A9,TNFRSF1B,CD36 0.086398 0.530807 MAPK14,F2,HSP90AB1,IL1R1,IL18,LAG3,LBP,LEP,LGALS9,MDK,PLA2G2A,PRKACA,MAPK3,PTPN6,PTPN11,S100A9,S100A12,SAA1,STAT1,S MAS vs. active sJIA GO_REGULATION_OF_DEFENSE_RESPONSE 747 199 22 TAT3,TNFRSF1B,IL1RL1 0.086542 0.530807 MAS vs. active sJIA GO_REGULATION_OF_GROWTH 686 146 17 MAPK14,ENO1,F2,BMP10,HTRA2,HRG,HSPA1A,IGFBP2,LEP,POR,PRSS2,HAMP,S100A9,SHC1,STAT3,TKT,NTN1 0.086611 0.530807 MAS vs. active sJIA GO_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY30 13 3 BAD,YWHAB,YWHAZ 0.086685 0.530807 MAS vs. active sJIA GO_CELLULAR_DEFENSE_RESPONSE 54 13 3 GNLY,LBP,CXCL9 0.086685 0.530807 MAS vs. active sJIA GO_REGULATORY_T_CELL_DIFFERENTIATION 35 13 3 LAG3,LGALS9,MDK 0.086685 0.530807 MAS vs. active sJIA GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION28 13 3 F2,HRG,BAD 0.086685 0.530807 MAS vs. active sJIA GO_REGULATION_OF_GENE_SILENCING 139 13 3 MAP2K1,STAT3,H3C1 0.086685 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS 29 13 3 LBP,MDK,RAC1 0.086685 0.530807 MAS vs. active sJIA GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS 33 13 3 LBP,MDK,RAC1 0.086685 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT 40 13 3 PDGFA,PDGFB,RET 0.086685 0.530807 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING38 13 3 FGG,MDK,RAC1 0.086685 0.530807 MAS vs. active sJIA GO_REGULATION_OF_MAP_KINASE_ACTIVITY 342 105 13 MAPK14,ITGA1,PDGFA,PDGFB,MAPK3,MAP2K1,PTPN6,PTPN11,RET,S100A12,SAA1,MAP2K4,SHC1 0.087124 0.532124 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY 201 47 7 MAPK14,HTRA2,LGALS9,MAPK3,BAD,S100A9,STAT3 0.088452 0.53597 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING88 47 7 F2,IL18,LEP,PDGFA,PDGFB,PTPN6,CAT 0.088452 0.53597 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION 414 136 16 ICOSLG,IGFBP2,IGHM,IL18,LBP,LEP,LGALS9,MDK,PRKCZ,BAD,PTPN6,PTPN11,RAC1,YES1,IL1RL1,CD27 0.088468 0.53597 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION 105 38 6 IL18,LGALS9,MDK,PRKCZ,BAD,CD27 0.088878 0.53597 MAS vs. active sJIA GO_NEGATIVE_REGULATION_OF_WOUND_HEALING 78 38 6 F2,FAP,FGG,HRG,PDGFA,PDGFB 0.088878 0.53597 MAS vs. active sJIA GO_T_CELL_DIFFERENTIATION 253 66 9 IL18,LAG3,LEP,LGALS9,MDK,PRKCZ,BAD,STAT3,CD27 0.089912 0.54024 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS 80 21 4 MAPK14,F2,HSP90AB1,LEP 0.09004 0.54024 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION 350 116 14 ICOSLG,IGFBP2,IGHM,IL18,LEP,LGALS9,MDK,PRKCZ,BAD,PTPN6,PTPN11,RAC1,YES1,CD27 0.09147 0.547439 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_PROTEOLYSIS 369 76 10 MAPK14,ENO1,HTRA2,HSPA1A,LGALS9,MAPK3,BAD,S100A9,STAT3,TNFRSF1B 0.091957 0.548165 MAS vs. active sJIA GO_CELL_GROWTH 490 106 13 ENO1,F2,BMP10,HRG,HSPA1A,HSP90AA1,HSP90AB1,PRKCZ,PRSS2,HAMP,S100A9,MAP2K4,NTN1 0.092466 0.548165 MAS vs. active sJIA GO_METAL_ION_HOMEOSTASIS 658 96 12 CXCL13,F2,FTH1,LCN2,CXCL9,PRKACA,PTPN6,HAMP,S100A9,SAA1,TPT1,CD36 0.092988 0.548165 MAS vs. active sJIA GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION 181 57 8 IL18,LAG3,LGALS9,MDK,PRKCZ,BAD,PTPN6,CD27 0.093729 0.548165 MAS vs. active sJIA GO_REGULATION_OF_CELL_CELL_ADHESION 439 148 17 CXCL13,MAPK14,FGG,ICOSLG,IGFBP2,IL18,LAG3,LEP,LGALS9,MDK,PRKCZ,BAD,PTPN6,PTPN11,RAC1,YES1,CD27 0.095796 0.548165 MAS vs. active sJIA GO_ORGANOPHOSPHATE_METABOLIC_PROCESS 1057 117 14 NAMPT,AKR1A1,ADSL,ENO1,GPI,PDGFA,PDGFB,PGAM1,PLA2G2A,BAD,STAT3,TKT,TPI1,DCTPP1 0.096728 0.548165 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS 96 48 7 CXCL13,MAPK14,LBP,LGALS9,MDK,MAPK3,RAC1 0.096732 0.548165 MAS vs. active sJIA GO_REGULATION_OF_T_CELL_DIFFERENTIATION 150 48 7 IL18,LAG3,LGALS9,MDK,PRKCZ,BAD,CD27 0.096732 0.548165 MAS vs. active sJIA GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE83 30 5 IL1R1,IL18,PRKCZ,TNFRSF1B,CD36 0.096917 0.548165 MAPK14,GRK2,F2,FGG,HTRA2,GPI,HSPA1A,HSPA8,HSP90AB1,LEP,LGALS9,CXCL9,PDGFB,PRKACA,PRKCZ,MAPK3,MAP2K1,PRTN3,BAD,PT MAS vs. active sJIA GO_REGULATION_OF_TRANSPORT 1856 301 31 PN6,PTPN11,HAMP,RAC1,SAA1,STAT3,TNFRSF1B,YES1,YWHAB,YWHAZ,IL1RL1,CD36 0.097739 0.548165 MAS vs. active sJIA GO_POSITIVE_REGULATION_OF_SECRETION 372 87 11 GRK2,FGG,GPI,LEP,LGALS9,BAD,PTPN11,RAC1,SAA1,STAT3,IL1RL1 0.09908 0.548165 CXCL13,MAPK14,FAP,BMP10,HRG,IL18,LEP,MDK,CXCL9,CDON,CLEC1B,PDGFA,PRKACA,MAPK3,MAP2K1,PTPN6,PTPN11,RET,SHC1,STAT MAS vs. active sJIA GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS1202 224 24 1,STAT3,THBS2,YWHAZ,CD36 0.099626 0.548165 sJIA-PAP vs all sJIA GO_MONOCYTE_CHEMOTAXIS 66 44 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.000173 0.16479 sJIA-PAP vs all sJIA GO_LYMPHOCYTE_MIGRATION 116 52 6 RET,CCL7,CCL11,CCL15,CCL17,CCL25 0.000447 0.16479 sJIA-PAP vs all sJIA GO_LYMPHOCYTE_CHEMOTAXIS 64 34 5 CCL7,CCL11,CCL15,CCL17,CCL25 0.00046 0.16479 sJIA-PAP vs all sJIA GO_NEUTROPHIL_CHEMOTAXIS 102 58 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.000817 0.210097 sJIA-PAP vs all sJIA GO_RESPONSE_TO_CHEMOKINE 96 41 5 CCL7,CCL11,CCL15,CCL17,CCL25 0.001122 0.210097 sJIA-PAP vs all sJIA GO_NEUTROPHIL_MIGRATION 121 62 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.001173 0.210097 sJIA-PAP vs all sJIA GO_MONONUCLEAR_CELL_MIGRATION 96 64 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.001391 0.213548 sJIA-PAP vs all sJIA GO_RESPONSE_TO_INTERFERON_GAMMA 201 67 6 CCL7,CCL11,CCL15,CCL17,CCL25,KYNU 0.001775 0.228367 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_GTPASE_ACTIVITY 404 46 5 CCL7,CCL11,CCL15,CCL17,CCL25 0.001912 0.228367 sJIA-PAP vs all sJIA GO_GRANULOCYTE_CHEMOTAXIS 126 74 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.002985 0.299129 sJIA-PAP vs all sJIA GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR 319 102 7 HAMP,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ 0.003342 0.299129 sJIA-PAP vs all sJIA GO_GLIAL_CELL_DERIVED_NEUROTROPHIC_FACTOR_RECEPTOR_SIGNALING_PATHWAY10 5 2 RET,GDF15 0.003931 0.299129 sJIA-PAP vs all sJIA GO_METANEPHRIC_GLOMERULUS_DEVELOPMENT 16 5 2 RET,ADIPO Q 0.003931 0.299129 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_GLOMERULUS_DEVELOPMENT 11 5 2 RET,ADIPO Q 0.003931 0.299129 sJIA-PAP vs all sJIA GO_GRANULOCYTE_MIGRATION 149 79 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.004174 0.299129 sJIA-PAP vs all sJIA GO_REGULATION_OF_GTPASE_ACTIVITY 479 57 5 CCL7,CCL11,CCL15,CCL17,CCL25 0.004997 0.335741 sJIA-PAP vs all sJIA GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT 15 6 2 RET,ADIPO Q 0.005822 0.368149 sJIA-PAP vs all sJIA GO_REGULATION_OF_MAPK_CASCADE 751 213 10 REN,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.006623 0.395535 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT 14 7 2 RET,ADIPO Q 0.008048 0.455323 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY 1469 296 12 ANG,IL18,POR,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.008567 0.455975 sJIA-PAP vs all sJIA GO_ORGANIC_ACID_CATABOLIC_PROCESS 282 23 3 NAGK,KYNU,ADIPO Q 0.010465 0.455975 sJIA-PAP vs all sJIA GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION 25 8 2 IL18,CCL17 0.010595 0.455975 sJIA-PAP vs all sJIA GO_METANEPHRIC_NEPHRON_DEVELOPMENT 40 8 2 RET,ADIPO Q 0.010595 0.455975 sJIA-PAP vs all sJIA GO_REGULATION_OF_METANEPHROS_DEVELOPMENT 23 8 2 RET,ADIPO Q 0.010595 0.455975 sJIA-PAP vs all sJIA GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS 507 96 6 MMP7,POR,HAMP,KYNU,ADIPOQ,GDF15 0.010944 0.455975 sJIA-PAP vs all sJIA GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION 952 266 11 IL18,REN,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.011028 0.455975 sJIA-PAP vs all sJIA GO_RESPONSE_TO_NUTRIENT 171 46 4 POR,HAMP,KYNU,ADIPOQ 0.01283 0.510817 sJIA-PAP vs all sJIA GO_RESPONSE_TO_INTERLEUKIN_1 210 72 5 CCL7,CCL11,CCL15,CCL17,CCL25 0.013494 0.518068 sJIA-PAP vs all sJIA GO_SMALL_MOLECULE_CATABOLIC_PROCESS 452 49 4 FUT5,NAGK,KYNU,ADIPOQ 0.015968 0.57565 sJIA-PAP vs all sJIA GO_RESPONSE_TO_BIOTIC_STIMULUS 1615 362 13 CCDC80,ANG,IL18,HAMP,REN,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,KYNU,ADIPOQ 0.016573 0.57565 sJIA-PAP vs all sJIA GO_CHOLESTEROL_EFFLUX 64 10 2 APOM,ADIPOQ 0.0166 0.57565 sJIA-PAP vs all sJIA GO_LIPID_OXIDATION 111 11 2 POR,ADIPOQ 0.020034 0.662601 sJIA-PAP vs all sJIA GO_MYELOID_LEUKOCYTE_MIGRATION 221 111 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.021598 0.662601 sJIA-PAP vs all sJIA GO_LEUKOCYTE_CHEMOTAXIS 231 112 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.022497 0.662601 sJIA-PAP vs all sJIA GO_STEROL_HOMEOSTASIS 102 12 2 IL18,APO M 0.023738 0.662601 sJIA-PAP vs all sJIA GO_CELL_MATURATION 179 32 3 ANG,REN,RET 0.025914 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION 1823 342 12 ANG,IL18,POR,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.027556 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT 40 13 2 RET,ADIPO Q 0.027701 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_ETHANOL 122 33 3 HAMP,CCL7,ADIPOQ 0.028119 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_MAPK_CASCADE 553 187 8 RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,GDF15 0.028609 0.662601 sJIA-PAP vs all sJIA GO_LEUKOCYTE_MIGRATION 514 187 8 MMP1,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.028609 0.662601 sJIA-PAP vs all sJIA GO_ERK1_AND_ERK2_CASCADE 324 119 6 CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ 0.029532 0.662601 sJIA-PAP vs all sJIA GO_RENAL_SYSTEM_PROCESS 125 14 2 REN,ADIPO Q 0.031913 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_XENOBIOTIC_STIMULUS 130 14 2 POR,S100A12 0.031913 0.662601 sJIA-PAP vs all sJIA GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE 68 14 2 APOM,ADIPOQ 0.031913 0.662601 sJIA-PAP vs all sJIA GO_CELLULAR_RESPONSE_TO_DRUG 71 14 2 REN,ADIPO Q 0.031913 0.662601 sJIA-PAP vs all sJIA GO_INNATE_IMMUNE_RESPONSE 986 230 9 ANG,IL18,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,KYNU 0.033515 0.662601 sJIA-PAP vs all sJIA GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT 268 36 3 APOM,REN,ADIPOQ 0.035323 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE 214 92 5 CCL7,CCL11,CCL15,CCL17,CCL25 0.035676 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION32 15 2 IL18,ADIPO Q 0.036361 0.662601 sJIA-PAP vs all sJIA GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY 34 15 2 ANG,IL18 0.036361 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION 53 15 2 IL18,CCL17 0.036361 0.662601 sJIA-PAP vs all sJIA GO_EOSINOPHIL_CHEMOTAXIS 18 15 2 CCL7,CCL11 0.036361 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_CAMP 94 15 2 REN,ADIPO Q 0.036361 0.662601 sJIA-PAP vs all sJIA GO_EOSINOPHIL_MIGRATION 22 15 2 CCL7,CCL11 0.036361 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION1054 276 10 IL18,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.039544 0.662601 sJIA-PAP vs all sJIA GO_CELLULAR_AMIDE_METABOLIC_PROCESS 1192 95 5 FUT5,ANG,NAGK,REN,KYNU 0.040274 0.662601 sJIA-PAP vs all sJIA GO_EXTRACELLULAR_MATRIX_DISASSEMBLY 82 39 3 MMP1,MMP7,CAPN1 0.043403 0.662601 sJIA-PAP vs all sJIA GO_CELLULAR_LIPID_METABOLIC_PROCESS 1098 97 5 FUT5,ANG,POR,APOM,ADIPOQ 0.043537 0.662601 sJIA-PAP vs all sJIA GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION69 17 2 ANG,ADIPOQ 0.045924 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION73 17 2 HAMP,GDF15 0.045924 0.662601 sJIA-PAP vs all sJIA GO_MAMMARY_GLAND_MORPHOGENESIS 45 17 2 CCL11,CAPN1 0.045924 0.662601 sJIA-PAP vs all sJIA GO_FOAM_CELL_DIFFERENTIATION 38 17 2 IL18,ADIPO Q 0.045924 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_KIDNEY_DEVELOPMENT 56 17 2 RET,ADIPO Q 0.045924 0.662601 sJIA-PAP vs all sJIA GO_CELL_CHEMOTAXIS 310 135 6 S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.050857 0.662601 sJIA-PAP vs all sJIA GO_STEROL_TRANSPORT 118 18 2 APOM,ADIPOQ 0.051019 0.662601 sJIA-PAP vs all sJIA GO_DEFENSE_RESPONSE_TO_FUNGUS 41 18 2 HAMP,S100A12 0.051019 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS 1260 330 11 ANG,IL18,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.052161 0.662601 sJIA-PAP vs all sJIA GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM 1203 289 10 ANG,IL18,HAMP,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,KYNU 0.052722 0.662601 sJIA-PAP vs all sJIA GO_CHEMICAL_HOMEOSTASIS 1213 173 7 IL18,APOM,HAMP,CCL7,CCL11,CCL15,ADIPOQ 0.054018 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY 771 137 6 ANG,CCL7,CCL11,CCL15,CCL17,CCL25 0.054069 0.662601 sJIA-PAP vs all sJIA GO_METANEPHROS_DEVELOPMENT 91 19 2 RET,ADIPO Q 0.05631 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_IONIZING_RADIATION 144 19 2 HAMP,CCL7 0.05631 0.662601 sJIA-PAP vs all sJIA GO_GLOMERULUS_DEVELOPMENT 64 19 2 RET,ADIPO Q 0.05631 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_COLD_INDUCED_THERMOGENESIS 97 19 2 IL18,ADIPO Q 0.05631 0.662601 sJIA-PAP vs all sJIA GO_ANATOMICAL_STRUCTURE_MATURATION 234 44 3 ANG,REN,RET 0.058766 0.662601 sJIA-PAP vs all sJIA GO_INFLAMMATORY_RESPONSE 801 254 9 IL18,HAMP,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ 0.05936 0.662601 sJIA-PAP vs all sJIA GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS 672 74 4 LDHB,POR,KYNU,ADIPOQ 0.061004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_PHOSPHORYLATION 1668 381 12 ANG,IL18,REN,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.061028 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_BACTERIUM 743 178 7 CCDC80,ANG,IL18,HAMP,REN,S100A12,ADIPOQ 0.061601 0.662601 sJIA-PAP vs all sJIA GO_LIPID_MODIFICATION 271 20 2 POR,ADIPOQ 0.061787 0.662601 sJIA-PAP vs all sJIA GO_LIPID_HOMEOSTASIS 163 20 2 IL18,APO M 0.061787 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS 1915 388 12 ANG,IL18,REN,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.069266 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS 1180 345 11 ANG,IL18,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.069702 0.662601 sJIA-PAP vs all sJIA GO_FEEDING_BEHAVIOR 105 22 2 REN,GDF15 0.073262 0.662601 sJIA-PAP vs all sJIA GO_COLLAGEN_CATABOLIC_PROCESS 47 22 2 MMP1,MMP7 0.073262 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION 1864 351 11 IL18,REN,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.077752 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_FUNGUS 54 23 2 HAMP,S100A12 0.079242 0.662601 sJIA-PAP vs all sJIA GO_CARBOHYDRATE_METABOLIC_PROCESS 630 81 4 FUT5,LDHB,NAGK,ADIPOQ 0.079954 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_DRUG 397 81 4 POR,REN,RET,ADIPOQ 0.079954 0.662601 sJIA-PAP vs all sJIA GO_DEVELOPMENTAL_MATURATION 286 50 3 ANG,REN,RET 0.080178 0.662601 sJIA-PAP vs all sJIA GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION 396 115 5 CCDC80,MMP1,MMP7,ICAM5,CAPN1 0.080207 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS 1868 399 12 ANG,IL18,REN,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25,ADIPOQ,GDF15 0.083758 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND 149 24 2 REN,ADIPO Q 0.085374 0.662601 sJIA-PAP vs all sJIA GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM 65 24 2 HAMP,S100A12 0.085374 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_ORGANOPHOSPHORUS 134 24 2 REN,ADIPO Q 0.085374 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION 119 24 2 HAMP,GDF15 0.085374 0.662601 sJIA-PAP vs all sJIA GO_AGING 319 83 4 MMP7,HAMP,CCL11,KYNU 0.085868 0.662601 sJIA-PAP vs all sJIA GO_TAXIS 656 232 8 FLRT3,RET,S100A12,CCL7,CCL11,CCL15,CCL17,CCL25 0.087272 0.662601 sJIA-PAP vs all sJIA GO_ORGANIC_ACID_METABOLIC_PROCESS 1183 118 5 LDHB,POR,NAGK,KYNU,ADIPOQ 0.087606 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_ACTIVITY 539 155 6 ANG,IL18,RET,S100A12,ADIPOQ,GDF15 0.088736 0.662601 sJIA-PAP vs all sJIA GO_MYOBLAST_DIFFERENTIATION 86 25 2 IL18,CCL17 0.091647 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS 105 25 2 APOM,ADIPOQ 0.091647 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_RADIATION 446 53 3 HAMP,CCL7,CCL11 0.09202 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_ALCOHOL 234 53 3 HAMP,CCL7,ADIPOQ 0.09202 0.662601 sJIA-PAP vs all sJIA GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES277 53 3 FLRT3,RET,ADIPOQ 0.09202 0.662601 sJIA-PAP vs all sJIA GO_ADAPTIVE_THERMOGENESIS 155 26 2 IL18,ADIPO Q 0.098056 0.662601 sJIA-PAP vs all sJIA GO_NATURAL_KILLER_CELL_PROLIFERATION 11 5 1 IL18 0.099004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN19 5 1 REN 0.099004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_ANGIOTENSIN_LEVELS_IN_BLOOD 12 5 1 REN 0.099004 0.662601 sJIA-PAP vs all sJIA GO_NEGATIVE_REGULATION_OF_CELLULAR_EXTRAVASATION 9 5 1 CCL25 0.099004 0.662601 sJIA-PAP vs all sJIA GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT 19 5 1 POR 0.099004 0.662601 sJIA-PAP vs all sJIA GO_AMINO_SUGAR_METABOLIC_PROCESS 41 5 1 NAGK 0.099004 0.662601 sJIA-PAP vs all sJIA GO_FATTY_ACID_BETA_OXIDATION 74 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_NEURON_CELL_CELL_ADHESION 17 5 1 RET 0.099004 0.662601 sJIA-PAP vs all sJIA GO_NEGATIVE_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY13 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY24 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX 20 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_GRANULOCYTE_DIFFERENTIATION 34 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY 13 5 1 ANG 0.099004 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION 20 5 1 IL18 0.099004 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_VITAMIN_A 19 5 1 HAMP 0.099004 0.662601 sJIA-PAP vs all sJIA GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY 16 5 1 APOM 0.099004 0.662601 sJIA-PAP vs all sJIA GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE 17 5 1 APOM 0.099004 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_IMMOBILIZATION_STRESS 26 5 1 REN 0.099004 0.662601 sJIA-PAP vs all sJIA GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS 97 5 1 KYNU 0.099004 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION 7 5 1 IL18 0.099004 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY 38 5 1 POR 0.099004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS 18 5 1 POR 0.099004 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_PAIN 30 5 1 RET 0.099004 0.662601 sJIA-PAP vs all sJIA GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS29 5 1 POR 0.099004 0.662601 sJIA-PAP vs all sJIA GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT 19 5 1 FLRT3 0.099004 0.662601 sJIA-PAP vs all sJIA GO_GLYCOSYLATION 264 5 1 FUT5 0.099004 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTACTIC_PROTEIN_1_PRODUCTION12 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_RESPONSE_TO_EPINEPHRINE 16 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS 13 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT26 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS 35 5 1 KYNU 0.099004 0.662601 sJIA-PAP vs all sJIA GO_MODULATION_OF_AGE_RELATED_BEHAVIORAL_DECLINE 9 5 1 CCL11 0.099004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_RENAL_SYSTEM_PROCESS 35 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING 16 5 1 ADIPOQ 0.099004 0.662601 sJIA-PAP vs all sJIA GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS 26 5 1 NAGK 0.099004 0.662601 sJIA-PAP vs all sJIA GO_POSITIVE_REGULATION_OF_CELL_MATURATION 10 5 1 RET 0.099004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_INTESTINAL_ABSORPTION 11 5 1 HAMP 0.099004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_NMDA_RECEPTOR_ACTIVITY 36 5 1 CAPN1 0.099004 0.662601 sJIA-PAP vs all sJIA GO_REGULATION_OF_T_HELPER_1_CELL_CYTOKINE_PRODUCTION 5 5 1 IL18 0.099004 0.662601 Table S6 Pathology and immunostaining characteristics of patient lung specimens

Patient Diagnosis Age Major histologic IL-18 ICAM-5 MMP-7 CCL2 Galectin-3 CCL17 Code (Years) findings 1 sJIA 2 PAP/ELP ++ +++ ++ +++ +++ +

2 sJIA 1.5 PAP ND ++ + +++ +++ ND

3 sJIA 11 ELP +++ ND + ++ + ND

4* sJIA 5 PAP ++ + + ND + ND

5 sJIA 3 PAP/ELP ND ++ + ND +++ ND

6 sJIA 2 PAP ND + ++ ND ND -

7 sJIA 3 Limited ELP ND ++ - ND ND ND

8 sJIA 6 PAP/ELP + ++ + ND ND + 8* 7 PAP + ++ + + 9 GATA2 20 PAP/ELP/Fibrosis/PH ++ +++ ++ +++ +++ ND TN 10 SFTPC 1.5 Chronic pneumonitis ++ ++ + ++ +++ ND of Infancy 11* NKX2.1 5 ELP/Fibrosis +++ ND ++ ++ ++ ND

12 Idiopathic 9 Chronic ++ + + ++ +++ ND ILD bronchiolitis/PAP 13 Control 11 Asthma/Aspiration + ++ -/+ ++ +++ ND

14* Control 2 Acute - + -/+ +++ +++ ND bronchopneumonia 15 Control 5 Lung adjacent to + + + ND ND + tumor

* Lung sample obtained at autopsy; remainder are surgical lung biopsies

PAP, pulmonary alveolar proteinosis; ELP, endogenous lipoid pneumonia; NSIP, non-specific interstitial pneumonia; VOD, veno- occlusive disease; PHTN, pulmonary hypertension; ND, not done due to limited material.

+, rare/few foci/mild; ++, occasional/scattered foci/moderate; +++, frequent/many foci/severe Table S7: Demographics for the verification cohort

Patient Groups Age, median (IQR) Female % Inactive sJIA 11 (5-14) 85% (11/13) Active sJIA 7 (4.4-8.9) 50% (5/10) MAS 5 (2.2-16) 75% (6/8) sJIA-PAP* 7.6 (5.5-10) 53% (8/15)

Note: The disease characters for each cases of sJIA-PAP were shown in Table S1 Table S8: Protein abundance alterations in other types of ILDs identified in the literatures

Serum BAL fluid Gene Name sJIA-PAP IPF Study 1 IPF Study 2 RA-ILD* NEHI Surfactant mutant CCL11 Significant Not Significant Not Significant NA Not Significant Not Significant GDF15 Significant Not Significant Significant NA Not Significant Not Significant CCL17 Significant Not Significant Significant Significant Significant Significant CCL25 Significant Not Significant Not Significant NA Not Significant Not Significant CCL7 Significant Not Significant Not Significant NA Significant Significant ICAM5 Significant Significant Significant Significant Significant Not Significant LGALS3 Significant Not Significant Not Significant Significant Not Significant Not Significant MMP7 Significant Significant Not Significant Significant Not Significant Significant Ref Number 23 24 38 39 39

"Significant" means: 1. The author identified the protein abundance change and thus reported the summary statistics 2. AND the summary statistics pass the significance threshold as our study (sJIA-PAP): FDR < 20% and minimal fold change of 1.5. *: This study is only available thru an abstract, thus without full list of proteins with abundance change. We cannot determine whether other unreported proteins reached significance threshold in abundance change, so NA is reported.