Anti-INPP5E (full length) polyclonal antibody (CABT-BL4927) This product is for research use only and is not intended for diagnostic use.
PRODUCT INFORMATION
Product Overview Mouse Polyclonal antibody to Human INPP5E.
Immunogen Full length protein, (Human) INPP5E.
Isotype IgG
Source/Host Mouse
Species Reactivity Human
Purification Protein G purified
Conjugate Unconjugated
Applications WB
Format Liquid
Size 50 μg
Buffer 1×PBS, pH 7.2
Preservative None
Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
BACKGROUND
Introduction The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011]
GENE INFORMATION
Entrez Gene ID 56623
Protein Refseq NP_063945
UniProt ID Q9NRR6
Chromosome Location 9q34.3
Pathway 3-phosphoinositide degradation, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Phosphatidylinositol signaling system, organism-specific biosystem; Phosphatidylinositol signaling system, conserved biosystem;
Function hydrolase activity; inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-4, 5- bisphosphate 5-phosphatase activity;
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Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved