Anti-INPP5E (full length) polyclonal antibody (CABT-BL4927) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse Polyclonal antibody to Human INPP5E.

Immunogen Full length , (Human) INPP5E.

Isotype IgG

Source/Host Mouse

Species Reactivity Human

Purification Protein G purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 50 μg

Buffer 1×PBS, pH 7.2

Preservative None

Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.

BACKGROUND

Introduction The protein encoded by this is an inositol 1,4,5-trisphosphate (InsP3) 5-. InsP3 5- hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause ; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation

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Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved and various associated that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011]

GENE INFORMATION

Entrez Gene ID 56623

Protein Refseq NP_063945

UniProt ID Q9NRR6

Chromosome Location 9q34.3

Pathway 3-phosphoinositide degradation, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Phosphatidylinositol signaling system, organism-specific biosystem; Phosphatidylinositol signaling system, conserved biosystem;

Function activity; inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-4, 5- bisphosphate 5-phosphatase activity;

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Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved