Supplementary Table S4. DNA repair involvement of PARP inhibitor sensitisation found in the screen

Involved in Replication fork Previous publication stability/HR/Double Strand Break Repair or illustrating effect on PARP name Ensembl Gene ID BRCA1 function (yes if reference shown) Function inhibitor sensitivity BRCA1 ENSG00000012048 PMID: 10630642, PMID: 10549283 Critical HR factor. PMID: 15829967 NBN ENSG00000104320 PMID: 11062235, PMID: 9590181 Componant of the MRN complex PMID: 16912188 Fanconi's Anaemia . Provides critical bridge between the FA core FANCD2 ENSG00000144554 PMID: 11239454 complex and BRCA1 PMID: 16912188 RAD51C ENSG00000108384 PMID: 11331762 Rad51 homolog FANCO PMID: 23512992 RAD51D ENSG00000185379 PMID: 11751635 Accessory factor for recombination PMID: 21822267 Fanconi's Anaemia protein. Provides critical bridge between the FA core FANCE ENSG00000112039 PMID: 12093742 complex and FANCD2 RAD21 ENSG00000164754 PMID: 12546698 Sister cohesion FANCC ENSG00000158169 PMID: 15327776 Fanconi's Anaemia protein. PMID: 16912188 HUS1 ENSG00000136273 PMID: 16278671 Part of the 9-1-1 complex. Associated with ATR and TOPBP1 KAT5 ENSG00000172977 PMID: 16341205 aka TIP60. Mediates loading of HR repair ZSWIM7 ENSG00000214941 PMID: 16710300 aka SWS1. Part of SWS1-SWSAP1 complex RFC2 ENSG00000049541 PMID: 17170004 aka ELG1. Part of the RFC complex involved in PCNA loading TOPBP1 ENSG00000163781 PMID: 17765870 Activates ATR Part of the minichromosome maintenance (MCM) complex - a helicase MCM2 ENSG00000073111 PMID: 18180284 associated with replication forks Part of the minichromosome maintenance (MCM) complex - a helicase MCM3 ENSG00000112118 PMID: 18180284 associated with replication forks PMID: 18832051 Part of the minichromosome maintenance (MCM) complex - a helicase MCM6 ENSG00000076003 PMID: 18180284 associated with replication forks TEX11 ENSG00000120498 PMID: 18369460 NBN interacting protein involved in HR PMID: 18469862, PMID: 15572677 , PMID: DCLRE1B ENSG00000118655 15467758 5'-3' nuclease TIMELESS ENSG00000111602 PMID: 19112184 Sister chromatin cohesion BAP1 ENSG00000163930 PMID: 19117993 DUB enzyme involved in BRCA1 function ABL1 ENSG00000097007 PMID: 19285032 Abl kinase. Stablises RAD51/DNA nucleoprotein filament INIP ENSG00000148153 PMID: 19605351 aka SSB1. Associated with MRN complex SSRP1 ENSG00000149136 PMID: 19639603 aka FACT. Associated with RAD54 TOP3A ENSG00000177302 PMID: 19641493 Topisomerase/DNA unwinding. Forms complex with BLM. ESCO2 ENSG00000171320 PMID: 19738907 Sister chromatin cohesion ESCO1 ENSG00000141446 PMID: 19738907, PMID: 18614053 Sister chromatin cohesion aka HARP. SWI/SNF family member involved in chromatin remodelling at SMARCAL1 ENSG00000138375 PMID: 19841479, PMID: 22704558 DNA damage sites and/or replication forks SUMO1 ENSG00000116030 PMID: 20016603, PMID: 20016594 small ubiquitin-like modifier; modulates BRCA1 function PMID: 20049735, PMID: PMID: 20049735 , PMID: 22488521, PMID: 20944090, PMID: 23239809, PTEN ENSG00000171862 20944090 HR/maintainance of genomic stability PMID: 21468130 MUM1 ENSG00000160953 PMID: 20347427 Chromatin remodelling associated with stalled replication forks SMC3 ENSG00000108055 PMID: 20617204 Sister chromatin cohesion BRCC3 ENSG00000185515 PMID: 20817926 aka BRCC36. BRCA1 associated factor PMID: 21055983, PMID: 21055984, PMID: MMS22L ENSG00000146263 21055985 Required for RAD51 loading onto single stranded DNA Essential for RAD51/DNA nucleoprotein filament generation. Interacts with MND1 ENSG00000121211 PMID: 21151113, PMID: 17639081 PSMC3IP (HOP2) and DMC1. aka HOP2. Essential for RAD51/DNA nucleoprotein filament generation. PSMC3IP ENSG00000131470 PMID: 21151113, PMID: 17639081 Interacts with MND1 and DMC1. aka SNF2H. SWI/SNF family member .Chromatin remodelling at DNA SMARCA5 ENSG00000153147 PMID: 21172662 damage sites and/or replication forks USP1 ENSG00000162607 PMID: 21482670, PMID: 21896657 USP1/UAF1 complex PMID: 21482670 RAD54L ENSG00000085999 PMID: 21885354, PMID: 9774452 Accessory factor for recombination ATAD5 ENSG00000176208 PMID: 21896657, PMID: 19755857 aka ELG1. Modulates the USP1/UAF1 complex as part of the FA pathway INO80D ENSG00000114933 PMID: 21947284 Chromatin remodelling protein involved in DSBR RAD52 ENSG00000002016 PMID: 2195330 Accessory factor for recombination GADD45A ENSG00000116717 PMID: 22135303 Transduction of DNA damage induced stress signals PMID: 22357538, PMID: 17643121, PMID: FAM175A ENSG00000163322 17643122, PMID: 18077395 aka ABRA1, Abraxas. UBA1 ENSG00000130985 PMID: 22456334 Ubiquitin-activating enzyme. Modulates BRCA1 and 53BP1. RNF168 ENSG00000163961 PMID: 23055523 E3 ubiquitin ligase for DSB repair BARD1 ENSG00000138376 PMID: 23306437 exists as heterodimer with BRCA1 to provide ubiquitin E3 ligase activity RAD51 ENSG00000051180 PMID: 8929543 DNA recombinase that mediates strand invasion PMID: 16912188 XRCC2 ENSG00000196584 PMID: 9660962 Accessory factor for recombination CDC14B ENSG00000081377 Cell cycle checkpoint regulator which acts in response to DNA damage CDK7 ENSG00000134058 Kinase subunits of TFIIH CDK7, CCNH, MNAT1 PMID: 18832051 DNASE1L2 ENSG00000167968 DNA editing/nuclease DNMT3A ENSG00000119772 DNA methyltransferase GTF2H3 ENSG00000111358 Core TFIIH subunit p34 PMID: 18832051 HELLS ENSG00000119969 DNA helicase LIG3 ENSG00000005156 DNA ligase involved in BER PMID: 18832051 MLH1 ENSG00000076242 Mismatch repair. Part of MutL heterodimer. NAP1L1 ENSG00000187109 Chromatin remodelling at DNA damage sites and/or replication forks ORC1L ENSG00000085840 origin of replication complex ORC5L ENSG00000164815 origin of replication complex DNA polymerase associated with sister chromatin cohesion and DNA repair. PAPD7 ENSG00000112941 Involved in response to topoisomerase inhibitors POLB ENSG00000070501 DNA polymerase involved in BER POLD3 ENSG00000077514 DNA polymerase implicated in NER POLH ENSG00000170734 xeroderma pigmentosum (XP) variant PMID: 18832051 POLM ENSG00000122678 Gap filling during non-homologous end-joining POLR2F ENSG00000100142 DNA polymerase PRMT6 ENSG00000198890 Regulator of Base excision repair RRM1 ENSG00000167325 Ribonuclease reductase E3 ubiquitin ligase, SWI/SNF related, homolog of S. cerevisiae Rad5; SHPRH ENSG00000146414 damage discrimination at stalled replication forks SMARCA2 ENSG00000080503 Chromatin remodelling at DNA damage sites and/or replication forks Involved in nonsense mediated decay. Also associated with chekcpoint SMG1 ENSG00000157106 signalling in response to DNA damage TOP2B ENSG00000157107 Topisomerase/DNA unwinding involved in DNA replication USP10 ENSG00000157108 Ubiquitin specific protease involved in p53 activation aka HAUSP. Involved in p53 activation. Facilitates PTEN nuclear USP7 ENSG00000157109 localisation XRCC4 ENSG00000157110 Ligase accessory factor