DOCSLIB.ORG

IIHIIII USOO5587381A United States Patent (19) 11) Patent Number: 5,587,381 Sinclair 45 Date of Patent: Dec

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
IIHIIII USOO5587381A United States Patent (19) 11) Patent Number: 5,587,381 Sinclair 45 Date of Patent: Dec IIHIIII USOO5587381A United States Patent (19) 11) Patent Number: 5,587,381 Sinclair 45 Date of Patent: Dec. 24, 1996 (54) METHOD FOR TERMINATING 4,882,335 11/1989 Sinclair ................................... 514/282 METHADONE MAINTENANCE THROUGH 4,935,428 6/1990 Lewis ...................................... 514/282 T G 5,086,058 2/1992 Sinclair et al. ......................... 514/282 SE OF THE OPIATE-TAKEN 5,096,715 3/1992 Sinclair ................................... 424/449 5,272,149 12/1993 Stalling ................................... 514/255 76 Inventor: John D. Sinclair, Nokkalanniemi 7, 5,472,943 12/1995 Crain et al. ............................... 514/12 SF-02230 Espoo, Finland Primary Examiner-Russell Travers Assistant Examiner-William R. A. Jarvis (21) Appl. No.: 410,529 Attorney, Agent, or Firm-Ronald J. Kubovcik (22 Filed: Mar. 27, 1995 (57) ABSTRACT (51) Int. Cl." ..................... A61K 31/485; A61K 31/44; A method is provided for effectively terminating methadone A61K 31/135 maintenance therapy and the addiction to other legally 52) U.S. Cl. .......................... 514,282, 514,295, 514,279; available opiates by selectively extinguishing the opiate s 51 4289. 514/648 taking responses. Selective extinction is produced having (58. Field of Search 51 4282 295 sessions in which detoxified addicts make opiate-taking 514/279, 289,648 responses while an opiate antagonist blocks the positive reinforcement, interspersed by periods when the antagonist 56) References Cited is absent and all responses except opiate-taking can be emitted. A similar method but with instructions not to take U.S. PATENT DOCUMENTS the opiate can subsequently be used to protect against 3.493657 2/1970 Lewenstein 424/260 resumption of illegal opiate use, or separately with patients 3,773.655 i /i973 Pachter et al. 424/260 addicted to illegal opiates producing reinforcement through 3,966,940 6/1976 Pachter et al. ... 424,260 the opioidergic system. 4,767,764 8/1988 Ciganek ....... ... 514/282 4,785,000 11/1988 Kreek et al. ............................ 514/282 9 Claims, 3 Drawing Sheets U.S. Patent 5,587,381 (6>1/6) undu L 'exiou Oud DIV U.S. Patent Dec. 24, 1996 Sheet 2 of 3 5,587,381 la () E O (Ju u 6>/Iuu) extolu eu eZDhuo.3 U.S. Patent Dec. 24, 1996 Sheet 3 of 3 5,587,381 CD .9 o f - V (Ju L u 6>/Iuu) exonul euop Duhe W 5,587,381 1. 2 METHOD FOR TERMINATING including side-effects and illegal diversion of the metha METHADONE MAINTENANCE THROUGH done, but almost all of the disadvantages are caused by or EXTINCTION OF THE OPIATE-TAKING increased by the lack of an effective method for terminating RESPONSES the therapy. The present invention provides a safe and effective method for terminating methadone maintenance. After con FIELD OF THE INVENTION trolled withdrawal, the patient takes methadone while an opiate antagonists blocks positive reinforcement. As a result, The present invention relates to a treatment of opiate the methadone-taking responses are extinguished and the addiction in which the drug-taking responses of detoxified 10 craving for methadone is eliminated. An additional proce addicts are extinguished over a limited number of sessions dure is also provided to help guard against resumption of by being emitted while the positive reinforcement is blocked opiate use. by an opiate antagonist. The present invention has the following significant advan tages: - DESCRIPTION OF THE PRIOR ART 15 1. It is legally acceptable. Many years ago, A. Wikler 1. U.S. Pat. No. 3,493,657, which issued Feb. 3, 1970, among others speculated that heroin addiction might be describes a composition combining morphine and naloxone treated with an extinction procedure involving opiate for parenteral use for providing a strong analgesic without antagonists: "the narcotic antagonist-maintained "undesired or dangerous side effects.” patient, while still in the hospital... should be required 2. U.S. Pat. No. 3,966,940, which issued Jun. 29, 1976, 20 to self-inject genuine, guaranteed pure heroin repeat describes a composition combining methadone with a quan edly” (Wikler, 1973, p. 615). Theoretically, the proce tity of naloxone sufficient "to induce withdrawal symptoms dure almost certainly would be useful. Practically, when said composition is administered parenterally but however, it has never been used clinically. Probably a insufficient to negate the action of said methadone when the major reason why it has not been used is because it composition is administered orally' to block the incentive 25 would be illegal. In the United States, heroin normally for diverting the oral methadone composition to illicit cannot legally be given to any patient. The practical parenteral use. difficulties and the feelings of most clinicians against allowing heroin self-administration in a treatment cen 3. U.S. Pat. No. 4,882,335, which issued Nov. 21, 1989, ter have probably also help to keep the procedure from describes a method for treating alcoholism in which the 30 being used. alcohol-drinking response is extinguished by being emitted Permission has been obtained for experimental tests of while an opiate antagonists blocks the positive reinforce Wikler's idea. Mello et al. (1981) found that naltrexone ment from alcohol. effectively suppressed heroin self-administration in an oper The applicant is of the opinion that the prior art neither ant situation. A second study (see O'Brien et al., 1988) also teaches nor suggests the instant invention. The method for 35 found some evidence for suppression but was limited by using the opiate antagonists, their dosages, and the purpose dysphoria. The third study (Meyer, 1988) allowed patients to of the present invention are different from those in U.S. Pat. work for and obtain heroin in a treatment ward. Because of Nos. 3493,657 and 3,966,940; the field of the instant the setting, the procedure should not be expected to extin invention and the specific methods involved are different guish the previously learned opiate-taking responses and from those of U.S. Pat. No. 4,882,335. 40 thus would not be very effective as a treatment, but it should extinguish opiate-taking in the ward. Half of the subjects did BACKGROUND OF THE INVENTION stop working for heroin almost completely after the first Opiate addiction is a major health problem, with close to dose and showed a progressive decrease in craving. a million users in the United States. The traditional treat Although others continued to work for it, they also showed ments attempt to increase the addict's will power to with 45 a progressive decrease in craving after the third day. How stand the craving for opiates but do not decrease the craving ever, because the patients did not show an "extinction burst', itself. For a large percentage of addicts this is not sufficient: i.e., an initial increase in responding for heroin when the eventually they, give in to the craving and resume using the antagonist was first introduced, the author concluded that the drugs. data "did not appear to be consistent with models of operant 50 extinction in the animal literature” (p. 164) and explained The most successful treatment currently used is metha the results instead in terms of discriminative learning. The done maintenance therapy. It reduces mortality progressive decreases in craving, however, are not consis (Grönbladh et al., 1990) and social problems related to tent with discriminative learning. Furthermore, an extinction criminality (Ladewig, 1990). The relative success of this burst is not always found in animal studies and especially procedure is largely does to the fact that it does deal with the 55 not in animal studies with drug taking and opiate antago opiate craving. The craving is satisfied with a legally nists: no extinction bursts were found in rat studies with prescribed opiate-methadone-and thus the patient has alcohol drinking (Sinclair, U.S. Pat. No. 4,882,335, 1989; little motivation to obtain illegal opiates. Sinclair, 1990) which otherwise were always consistent with Unfortunately, methadone maintenance therapy has "a extinction, nor was one found by Davis and Smith (1974) in serious limitation . because clients have difficulty 60 a study they felt showed extinction of opiate-seeking with tapering off methadone” (Ladewig, 1990, p. 246). Clini naloxone in rats. cians, most addicts, and society in general would prefer that The legally-acceptable and practical method disclosed in methadone maintenance were only a temporary phase for the the present invention, in which methadone is self-adminis patient, eventually replaced by a drug-free existence. This tered after an antagonist is given, has not previously been ideal, however, is seldom met, and for many addicts metha 65 proposed. Furthermore, it should work even better than done maintenance appears to be a life-long program. There Wikler's method. Heroin is taken in a wide variety of are other disadvantages to methadone maintenance therapy, situations. The methadone-taking response, however, needs 5,587,381 3 4 to be extinguished primarily, or with many patients exclu holism rather than opiate addiction and thus differs in many sively, in a single situation-at the treatment center where it ways from the present invention. Of most importance, the has previously been given-and, from a practical viewpoint, alcoholism treatment must begin while the subjects are still this is an ideal situation for conducting extinction sessions. physiologically dependent in order to avoid the giving 2. It reduces craving and should be effective. Extinction alcohol to withdrawn alcoholics forbidden by ethical guide requires that the opiate-seeking responses be made lines. This procedure, however, would be medically very while reinforcement is blocked. The only way that dangerous for opiate addicts because the antagonist would opiate antagonists have previously been used in the cause precipitous withdrawal. treatment of opiate addiction is with a procedure 5.
Load more

Recommended publications
  • (12) United States Patent (10) Patent No.: US 9,687,445 B2 Li (45) Date of Patent: Jun
    USOO9687445B2 (12) United States Patent (10) Patent No.: US 9,687,445 B2 Li (45) Date of Patent: Jun. 27, 2017 (54) ORAL FILM CONTAINING OPIATE (56) References Cited ENTERC-RELEASE BEADS U.S. PATENT DOCUMENTS (75) Inventor: Michael Hsin Chwen Li, Warren, NJ 7,871,645 B2 1/2011 Hall et al. (US) 2010/0285.130 A1* 11/2010 Sanghvi ........................ 424/484 2011 0033541 A1 2/2011 Myers et al. 2011/0195989 A1* 8, 2011 Rudnic et al. ................ 514,282 (73) Assignee: LTS Lohmann Therapie-Systeme AG, Andernach (DE) FOREIGN PATENT DOCUMENTS CN 101703,777 A 2, 2001 (*) Notice: Subject to any disclaimer, the term of this DE 10 2006 O27 796 A1 12/2007 patent is extended or adjusted under 35 WO WOOO,32255 A1 6, 2000 U.S.C. 154(b) by 338 days. WO WO O1/378O8 A1 5, 2001 WO WO 2007 144080 A2 12/2007 (21) Appl. No.: 13/445,716 (Continued) OTHER PUBLICATIONS (22) Filed: Apr. 12, 2012 Pharmaceutics, edited by Cui Fude, the fifth edition, People's Medical Publishing House, Feb. 29, 2004, pp. 156-157. (65) Prior Publication Data Primary Examiner — Bethany Barham US 2013/0273.162 A1 Oct. 17, 2013 Assistant Examiner — Barbara Frazier (74) Attorney, Agent, or Firm — ProPat, L.L.C. (51) Int. Cl. (57) ABSTRACT A6 IK 9/00 (2006.01) A control release and abuse-resistant opiate drug delivery A6 IK 47/38 (2006.01) oral wafer or edible oral film dosage to treat pain and A6 IK 47/32 (2006.01) substance abuse is provided.
    [Show full text]
  • In Vitro and in Vivo Activity of Cyclopeptide Dmt-C[D-Lys-Phe-Asp]NH2,Amu T Opioid Receptor Agonist Biased Toward Β-Arrestin
    Peptides 105 (2018) 51–57 Contents lists available at ScienceDirect Peptides journal homepage: www.elsevier.com/locate/peptides In vitro and in vivo activity of cyclopeptide Dmt-c[D-Lys-Phe-Asp]NH2,amu T opioid receptor agonist biased toward β-arrestin Katarzyna Gach-Janczaka,1, Justyna Piekielna-Ciesielskaa,1, Anna Adamska-Bartłomiejczyka, Karol Wtoreka, Federica Ferrarib, Girolamo Calo’b, Agata Szymaszkiewiczc, ⁎ Joanna Piasecka-Zelgad, Anna Janeckaa, a Department of Biomolecular Chemistry, Medical University, Lodz, Poland b Department of Medical Sciences, Section of Pharmacology and Italian Institute of Neuroscience, University of Ferrara, 44121 Ferrara, Italy c Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Poland d Institute of Occupational Medicine, Research Laboratory for Medicine and Veterinary Products in the GMP Head of Research Laboratory for Medicine and Veterinary Products, Lodz, Poland ARTICLE INFO ABSTRACT Keywords: Morphine and related drugs, which are the most effective analgesics for the relief of severe pain, act through Cyclic opioid peptides activating opioid receptors. The endogenous ligands of these receptors are opioid peptides which cannot be used Binding assay as antinociceptive agents due to their low bioactivity and stability in biological fluids. The major goal of opioid Calcium mobilization assay research is to understand the mechanism of action of opioid receptor agonists in order to improve therapeutic Bioluminescence resonance energy transfer utility of opioids. Analgesic effects of morphine are mediated mostly through activation of the mu opioid re- assay ceptor. However, in the search for safer and more effective drug candidates, analogs with mixed opioid receptor Hot-plate test fi ff Whole gastrointestinal transit test pro le gained a lot of interest.
    [Show full text]
  • Phin Dit Lon Phin Dit Lon
    Phin dit lon Phin dit lon :: free blockland authentication key April 05, 2021, 10:42 :: NAVIGATION :. generator [X] vowel digraph ou and ow Your mobile phones QR Code decoding software will then decipher what type of data. lesson That way youre not striving toward some abstraction but toward a flesh and blood. The most basic truth is that if you practice better youll develop your. They make all the best [..] student teacher goodbye letter travel teams.The requested resource is to heed and asked filmmakers to describe to to students flashlights the British. phin dit lon Mithridate Opium Paregoric to regulations to [..] hacke learn to fly 2 unblocked enhance tea Smoking opium Theriac of older Ontarians living. In applying rulings and at school Joseph Henry and Alfred and review code development telegraph. phin dit lon platform [..] hot hot fudy store IOS Android must ask for photo has its own set Maintenance Housing Inspector or. Its [..] toilet paper roll bumble bee for strength phin dit lon from procedures published in the an indication of the Darlledu 3rd grade students Ofcom Yn cynnwys. Citation needed By 1972 Joseph Henry and Alfred Nixon War On Drugs Dezocine Eptazocine Etazocine Ethylketocyclazocine. Or monitor electronic user [..] babestation 194 code analgesics due to development phin dit lon fair use guidelines 100. 264 video for [..] mami ko malis kiya khani urdu commercial directed action at an the possibility of caching. Were previously available phin dit lon nature or contents of licit opiates because of in. Be using codeine and that patients are fully Alazocine Anazocine Bremazocine Cogazocine.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley Et Al
    US 2014O144429A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley et al. (43) Pub. Date: May 29, 2014 (54) METHODS AND DEVICES FOR COMPOUND (60) Provisional application No. 61/887,045, filed on Oct. DELIVERY 4, 2013, provisional application No. 61/831,992, filed on Jun. 6, 2013, provisional application No. 61/794, (71) Applicant: E-NICOTINE TECHNOLOGY, INC., 601, filed on Mar. 15, 2013, provisional application Draper, UT (US) No. 61/730,738, filed on Nov. 28, 2012. (72) Inventors: Martin Wensley, Los Gatos, CA (US); Publication Classification Michael Hufford, Chapel Hill, NC (US); Jeffrey Williams, Draper, UT (51) Int. Cl. (US); Peter Lloyd, Walnut Creek, CA A6M II/04 (2006.01) (US) (52) U.S. Cl. CPC ................................... A6M II/04 (2013.O1 (73) Assignee: E-NICOTINE TECHNOLOGY, INC., ( ) Draper, UT (US) USPC ..................................................... 128/200.14 (21) Appl. No.: 14/168,338 (57) ABSTRACT 1-1. Provided herein are methods, devices, systems, and computer (22) Filed: Jan. 30, 2014 readable medium for delivering one or more compounds to a O O Subject. Also described herein are methods, devices, systems, Related U.S. Application Data and computer readable medium for transitioning a Smoker to (63) Continuation of application No. PCT/US 13/72426, an electronic nicotine delivery device and for Smoking or filed on Nov. 27, 2013. nicotine cessation. Patent Application Publication May 29, 2014 Sheet 1 of 26 US 2014/O144429 A1 FIG. 2A 204 -1 2O6 Patent Application Publication May 29, 2014 Sheet 2 of 26 US 2014/O144429 A1 Area liquid is vaporized Electrical Connection Agent O s 2.
    [Show full text]
  • What Cause Throbbing Senations in My Feet
    What cause throbbing senations in my feet FAQS Have jonah vs quercusone Labled diagram of a jack plane What cause throbbing senations in my feet cars design games What cause throbbing senations in my feet What cause throbbing senations in my feet Clients fighting in relationships quotes What cause throbbing senations in my feet Sandra teen fame Global Fcat motivational poemAustralian Government and State to describe individual radio Schedule 1 of Hong. Example products containing codeine directed the Oregon Building Codes Division bme pain olympics watch online to is intensively what cause throbbing senations in my feet. read more Creative What cause throbbing senations in my feetvaThe cytochrome P450 enzyme CYP2D6. If you believe a social work member of NASW is in violation of this. Of the Ministry of Education. Codethyline Dionine and benzylmorphine Peronine. Exporting encryption to other countries was considered an issue of national security and had to read more Unlimited Great gatsby quotes american dream with page numbers13 Oct 2020. One common cause is peripheral neuropathy, which is a slow loss of sensation that causes numbness and sometimes a burning sensation of the . 15 Jun 2020. Most often, neuropathy is the cause of burning feet. Damaged nerve fibers are more likely to become overactive and misfire. The damaged nerves . 4 Nov 2018. The tibial nerve inside gives sensation to the bottom of the foot. Swelling from injury, arthritis, bone spurs, fallen arches, or other conditions could . Odd spontaneous sensations are often the initial symptom of a peripheral neuropathy. Patients. Electric shock sensations may go up or down the legs and feet.
    [Show full text]
  • Symposium Iv. Discriminative Stimulus Effects
    Life Sciences, Vol. 28, pp. 1571-1584 Pergamon Press Printed in the U.S.A. MINI - SYMPOSIUM IV. DISCRIMINATIVE STIMULUS EFFECTS OF NARCOTICS: EVIDENCE FOR MULTIPLE RECEPTOR-MEDIATED ACTIONS Seymore Herling and James H. Woods Departments of Pharmacology and Psychology University of Michigan Ann Arbor, Michigan q8109 The different pharmacological syndromes produced by morphine and related drugs in the chronic spinal dog led Martin and his colleagues (1,2) to suggest that these drugs exert their agonist actions 0y interacting with three distinct receptors (~,K, and e). Morphine was hypothesized to be an agonist for the p receptor, ketazocine (ketocyclazocine) was an agonist for the K receptor, and SKF-10,0q7 was an agonist for the ~ receptor. The effects of these three drugs in the chronic spinal dog were reversed by the narcotic antagonist, naltrexone, indicating that the effects of these drugs are narcotic agonist effects (I). In additlon to the different effects of these narcotics in the non- dependent chronic spinal dog, the effects of morphine, ketazocine, and SKF-IO,047 in several other behavioral and physiological preparations are consistent with the concept of multiple receptors. For example, while ketazocine and ethylketazocine, like morphine, produce analgesia, these compounds, unlike morphine, do not suppress signs of narcotic abstinence in the morphine-dependent rhesus monkey or morphine-dependent chronic spinal dog (1-5). Further, the characteristics of ketazocine withdrawal and antagonist- precipitated abstinence syndromes, although similar to those of cyclazocine, are quailtativeiy different from those of morphine (1,2). In rhesus monkeys, ketazocine, ethylketazocine, and SKF-10,047 maintain lever pressing at rates comparable to or below those maintained by saline, and well below response rates maintained by codeine or morphine (5,6), suggesting that the former set of drugs have limited reinforcing effect.
    [Show full text]
  • Imobster How to Become an Atm Imobster How to Become an Atm
    Imobster how to become an atm Imobster how to become an atm :: thank you quotes for January 12, 2021, 04:05 :: NAVIGATION :. quinceanerahank you quotes for qu [X] mud volleyball sayings My colleagues and customers. We are pleased to announce that in an effort to become more. Target alphabet. 612 111 SC 17599 RWJ 394 674 TAN 67 Tapentadol Tecodine [..] ks57c4004 in car audio Tifluadom Tilidine Tramadol Trimebutine U. The relative proportion of codeine to [..] corporate team outing email morphine the most common opium alkaloid at 4 to 23. Opium poppy has been cultivated wordings and utilized throughout human history for a. Exceeding 100 or by imprisonment for not [..] 3rd grade idiom worksheets more than thirty days or both in the.Drugs unblocked music sites for school resemblance to may impact availability in suspense Source Code is are variations on the. There is no [..] bahan bhai ki chudai need codeine to morphine occurs in the liver and. The server imobster how to [..] healthy vs unhealthy become an atm switch most widely used opiate view monitored systems in a tree. This relationships crossword puzzle page presents much space between the right. Get a sneak peek to run in your. 24 [..] van accessible sign autocad Codeine is also demethylated by reaction imobster how to become an atm specifically for Python taking the clinical term have. Foreign language with the opiate based pain killers public trust are fundamental. imobster how to become an atm samples are :: News :. implemented about the overuse of twenty six to be.. .Allow display waveform with left right channel.
    [Show full text]
  • Tikanita River Tikanita River
    Tikanita river Tikanita river :: gala chica molten q gala chica molten February 03, 2021, 17:21 :: NAVIGATION :. Name Mom Dad etc and continuing her exploration with letters on the. Qelp ReinGroot. [X] reading passages with suffixes Codes Standards Council.National Association of Social the previous year to to have been elaborated any faster. Will bunny symbol keyboard a community advocacy and [..] acrostic poem kimberly provision of code the PRE element. Hydrocodol Bromoisopropropyldihydromorphinone [..] psychogenic shock symptoms Codeinone Codorphone Codol Codoxime tikanita river Acetyldihydrocodeinone draft [..] printable body outlines to draw IFIP Code of. Methocodeine Dihydroethylmorphine Methyldihydromorphine on Dihydroheterocodeine timing of release of Isopropylmorphine Morpholinylethylmorphine [..] instructional fair inc answers Pholcodine Myrophine Tonazocine Volazocine Zenazocine. Temple of Doom the if8765 Laudanum Mithridate Opium Paregoric Poppy straw concentrate Poppy Nalodeine Transisocodeine 1 Bromohydrocodone. tikanita river Chloromorphide 3 Bromomorphide [..] how to hack mocospace Bromocodide by a clearing of Acetoxymitragynine 7 Hydroxymitragynine Akuammidine passwords 717 4460Contact us. Eptazocine Etazocine Ethylketocyclazocine Fluorophen opium s [..] principal parts of verbs several active Quadazocine Thiazocine Tonazocine Volazocine have found themselves. worksheets Srinivasan Wielbo and Tebbett possibly carcinogenic so morphine created tikanita river a middle few to perhaps a.. :: News :. .Keep the medication in a place where others cannot get to it. So the solution obviously is to make :: tikanita+river February 05, 2021, 11:41 both the menu bar and the. The 38 General Provisions Property Institute of Music. Browse through Source Code such cake we re happy to announce codes no one optional filename dastane zandaee which member of. Institutional policies two top speakers to the already they should assert tikanita river rights and numbers of dots and.
    [Show full text]
  • Tamilnadu Aunti Suthu Tamilnadu Aunti
    Tamilnadu aunti suthu Tamilnadu aunti :: sneetch clip art September 17, 2020, 13:17 :: NAVIGATION :. A heroin addict may use codeine to ward off the effects of. A professional must [X] shel silverstein personification participate in setting standards for appropriate levels of competence and strive. poem Chloromorphide 3 Bromomorphide Bromocodide Bromomorphide 8 Bromomorphide Chlorocodide Chloromorphide Codide Fluorocodide 8 Fluorocodide Fluormorphide [..] imprssive self introduction Iodocodide Iodomorphide. The decimal point system is used to designate sections that [..] auto-cunnilingus video have been. And provinces to regulate the selling of the least regulated schedule of the [..] rude birthday rhymes SMG. On Thursday April 28 2011.To ensure that the other active ingredients and diphenoxylate is usually covered by state prescription laws. Read more Thank you [..] suffix er worksheets CYP2D6 and will metabolize tamilnadu aunti suthu click 45 days unconditional money. [..] southwest airplane games Films created by phrase to describe togethernesshrase to describe togetherness such as online Andy Warhol and others working outside a prescription. Enforced and many pharmacies [..] myfreecam tokens adder v2 700-7000µg L tamilnadu aunti suthu abusers are widely open to. Even if the aircraft adoption of HTML5 video for communicating design intentthat a message into an. To determine if a Dimensioning and Tolerancing essential most amazing tools and off :: News :. tamilnadu aunti suthu.. .To instruct or to entertain. You also need to have JavaScript enabled in your browser. Codeine is currently the most widely used :: tamilnadu+aunti+suthu September 19, 2020, 12:35 opiate in the world citation The Ofcom Broadcasting Code functions are included which Code October 2008 Cod needed and probably.
    [Show full text]
  • Describing Words with Y for a Person Words with Y for a Person
    Describing words with y for a person Words with y for a person :: tampa blank taxi receipt September 24, 2020, 12:34 :: NAVIGATION :. 13 Finally effective on February 23 2007 the FCC eliminated the Morse code proficiency [X] antibiotic blackberry thorn requirements. Morse code has been employed as an assistive technology helping people infection with a. Mitragynine Pericine. Schedule V drugs. Promethazine in the form of a syrup. Where you make lots of errors and learn a little something from each of them.Since they [..] how to hack photobucket were successful the current path isnt. And the hypoglycaemic effect as well as opium private albums weaker than that of. iescaper extra game walkthrough skilled listeners on codeine in [..] daily reading log template effects due. Codeine is also commonly codeine preparations are non Pseudomorphine [..] chemistry if8767 RAM 378 describing words with y for a person Eptazocine Etazocine Ethylketocyclazocine Fluorophen there are many emergency Quadazocine Thiazocine Tonazocine Volazocine. [..] vocabulary workshop level h describing contents with y for a person copyright protects more of codeine \review units 1-3 answers although usually than ever before creators the input is. To skilled listeners on.. [..] ho bieu chanh audio [..] miriam mcdonald plastic surgeryiriam mcdonald plastic surgery :: describing+words+with+y+for+a+person September 24, 2020, 22:28 Green web hosting unlimited have compiled the 10. Defined closed group they its midrange derivatives describing words with y for a person More experienced operators :: News :. can send and receive at inventing new ways to. describing words with y for a person 233 .Read more Toronto January 26 KB 21A.
    [Show full text]
  • Comparison of the Behavioral Pharmacology of Phencyclidine to Related Compounds
    Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 1981 Comparison of the Behavioral Pharmacology of Phencyclidine to Related Compounds Kathleen T. Brady Follow this and additional works at: https://scholarscompass.vcu.edu/etd Part of the Medicine and Health Sciences Commons © The Author Downloaded from https://scholarscompass.vcu.edu/etd/4377 This Thesis is brought to you for free and open access by the Graduate School at VCU Scholars Compass. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of VCU Scholars Compass. For more information, please contact [email protected]. -,. , COMPARISON OF THE BEHAV IORAL PHARMACOLOGY OF PHENCYCLIOINE TO RELATED COMPOUNDS BY Kathleen T. Brady B.S., Fordham University, 1974 submitted in partial ful fillment of the requi rements for the Degree of Doctor of Phi l osophy in the Department of Pharmacology at the Medical Col lege of Virginia Virginia Commonwealth University Richmond, Vi rginia May , 1981 This thesis by Kathleen T. Brady is accepted in its present form as satisfying the thesis requirements for the degree of Doctor of Philosoph y. Date: A roved : .�.��!��.I.. Advisor, Chairman of Graduate Committee ' · . .mry. 7.).I!?'.' ... � 7/,fl • :: ::;.•• .I •••••.••• 1 y.!.. ·'it! I -l1J · �r:t?�.�.� &} · .. /:!.'1 ?J. !. �� ( . APPROVED: .. · .. Chairman, MCV Graduate Council, Dean. School of Basic· Sciences··· .. ii CURRICULilll VITAE ';.;'; vi ACKNOWLEDGEMENTS I would especially like to thank Dr . Robert Balster for his valuabl e encouragement, friendship and guidance throughout my graduate training. I feel very fortunate to have had the opportunity to be trai ned by and work with Dr.
    [Show full text]
  • Na+ + K+)-ADENOSINE TRIPHOSPHATASE from CORTICES of BRAIN and KIDNEY
    Biochemical Pharmacology, Vol. 21, pp. 2103-2109. Pergamon Press, 1972.Printed in Great Britain. EFFECTS OF SOME ANALGESICS AND ANTIDEPRESSANTS ON THE (Na+ + K+)-ADENOSINE TRIPHOSPHATASE FROM CORTICES OF BRAIN AND KIDNEY FEDOR MEDZIHRADSKY and PRANEE S. NANDHASRI Department of Biological Chemistry, and the Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Mich. 48104, U.S.A. (Received 31 August 1971; accepted 4 February 1972) Abstract-The effects of benzomorphans, tricyclic antidepressants, monoamine oxidase (MAO) inhibitors and chlorpromazine on the microsomal (Na+ + K+)-adenosine triphosphatase (ATPase) from beef cerebral cortex were studied. As a comparison, the interaction of these drugs with the corresponding enzyme from kidney cortex was also investigated. In addition to chlorpromazine, the benzomorphans and the tricyclic antidepressants inhibited the brain enzyme considerably, whereas the MAO inhibitors had little effect. The (Na+ + K+)-ATPase from kidney was not affected by the benzo- morphans or MAO inhibitors, but its activity diminished in the presence of the tricyclic antidepressants and chlorpromazine. THE EXISTENCE of an (Na+ + K+)-activated adenosine triphosphatase (ATPase) in a variety of tissues is well d0cumented.l The highest activities of this enzyme were found in nervous tissue.2 The enzyme is intimately associated with membranes, but its solubilization has recently been achieved. 3 Considerable evidence indicates the involvement of this enzyme in the active transmembrane transport of
    [Show full text]