R Graphics Output

Gene Set 1728 : PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Gene Set Null Distribution Heat Map for Genes in Gene Set G1[B_Nov] G2[Non_B_Nov] Class PIK3R1

5 INPP4A PIP5K1A Gene Set Null Density PIK3R2 CALML3 Observed Gene Set ES value PIK3CA FN3K ITPK1 PIK3C2G PLCG1

4 CDIPT

0.0 INPP5B DGKQ PLCE1 INPPL1 ITPKA PLCB1 PLCB3 INPP1 PIK3CB 3 ITGB1BP3 OCRL PIK3R3 INPP5E ITPR2 IMPA1 Zero crossing at 6822 PRKCA CDS1 P(ES) −0.5 Peak at 9795 INPP4B 2 PIK3C2A PLCD1 DGKG INPP5D PIK3CD SYNJ2 PIK3CG ITPKB PLCB4 1

Running Enrichment Score (RES) CALM1 DGKZ SYNJ1 PTEN PIP5K1C PIP5K1B

−1.0 PIK3R5 PIK3C3 ITPR3

0 CALM3 PLCG2 Neg. ES "G2[Non_B_Nov]" Pos. ES: "G1[B_Nov]" DGKA "G1[B_Nov]" "G2[Non_B_Nov]" ITPR1 INPP5A IMPA2

0 2000 4000 6000 8000 10000 12000 −0.6 −0.4 −0.2 0.0 0.2 0.4 swp350.u133a.CEL JD.ALD509.v5.U133A.CEL JD.ALD096.v5.U133A.CEL JD.ALD108.v5.U133A.CEL JD.ALD057.v5.U133A.CEL JD.ALD232.v5.U133A.CEL JD.ALD294.v5.U133A.CEL JD.ALD385.v5.U133A.CEL JD.ALD052.v5.U133A.CEL JD.ALD078.v5.U133A.CEL JD.ALD433.v5.U133A.CEL JD.ALD180.v5.U133A.CEL JD.ALD009.v5.U133A.CEL JD.ALD388.v5.U133A.CEL JD.ALD428.v5.U133A.CEL JD.ALD494.v5.U133A.CEL JD.ALD035.v5.U133A.CEL JD.ALD039.v5.U133A.CEL JD.ALD391.v5.U133A.CEL JD.ALD264.v5.U133A.CEL JD.ALD386.v5.U133A.CEL JD.ALD387.v5.U133A.CEL JD.ALD389.v5.U133A.CEL JD.ALD390.v5.U133A.CEL JD.ALD008.v5.U133A.CEL JD.ALD613.v5.U133A.CEL JD0396.ALL.v5.U133A.CEL JD0108.ALL.v5.U133A.CEL JD0146.ALL.v5.U133A.CEL JD0360.ALL.v5.U133A.CEL JD0367.ALL.v5.U133A.CEL JD0314.ALL.v5.U133A.CEL JD0420.ALL.v5.U133A.CEL JD0343.ALL.v5.U133A.CEL JD0173.ALL.v5.U133A.CEL JD0258.ALL.v5.U133A.CEL JD0287.ALL.v5.U133A.CEL JD0181.ALL.v5.U133A.CEL JD0239.ALL.v5.U133A.CEL JD0032.ALL.v5.U133A.CEL JD0361.ALL.v5.U133A.CEL JD0336.ALL.v5.U133A.CEL JD0267.ALL.v5.U133A.CEL JD0323.ALL.v5.U133A.CEL JD0150.ALL.v5.U133A.CEL JD0059.ALL.v5.U133A.CEL JD0123.ALL.v5.U133A.CEL JD0056.ALL.v5.U133A.CEL JD0058.ALL.v5.U133A.CEL JD0139.ALL.v5.U133A.CEL JD0107.ALL.v5.U133A.CEL JD0109.ALL.v5.U133A.CEL JD0085.ALL.v5.U133A.CEL JD0253.ALL.v5.U133A.CEL JD0426.ALL.v5.U133A.CEL JD0286.ALL.v5.U133A.CEL JD0282.ALL.v5.U133A.CEL JD0318.ALL.v5.U133A.CEL JD0066.ALL.v5.U133A.CEL JD0016.ALL.v5.U133A.CEL JD0048.ALL.v5.U133A.CEL JD0086.ALL.v5.U133A.CEL JD0193.ALL.v5.U133A.CEL JD0280.ALL.v5.U133A.CEL JD0320.ALL.v5.U133A.CEL JD0330.ALL.v5.U133A.CEL JD0328.ALL.v5.U133A.CEL JD0250.ALL.v5.U133A.CEL JD0220.ALL.v5.U133A.CEL JD0304.ALL.v5.U133A.CEL JD0395.ALL.v5.U133A.CEL JD0341.ALL.v5.U133A.CEL JD0263.ALL.v5.U133A.CEL JD0364.ALL.v5.U133A.CEL JD0437.ALL.v5.U133A.CEL JD0436.ALL.v5.U133A.CEL JD0382.ALL.v5.U133A.CEL JD0354.ALL.v5.U133A.CEL JD0342.ALL.v5.U133A.CEL JD0238.ALL.v5.U133A.CEL JD0247.ALL.v5.U133A.CEL JD0264.ALL.v5.U133A.CEL JD0390.ALL.v5.U133A.CEL JD0423.ALL.v5.U133A.CEL JD0432.ALL.v5.U133A.CEL JD0344.ALL.v5.U133A.CEL JD0039.ALL.v5.U133A.CEL JD0255.ALL.v5.U133A.CEL JD0421.ALL.v5.U133A.CEL JD0408.ALL.v5.U133A.CEL JD0080.ALL.v5.U133A.CEL JD0084.ALL.v5.U133A.CEL JD0124.ALL.v5.U133A.CEL JD0284.ALL.v5.U133A.CEL JD0349.ALL.v5.U133A.CEL JD0103.ALL.v5.U133A.CEL JD0425.ALL.v5.U133A.CEL JD0225.ALL.v5.U133A.CEL JD0433.ALL.v5.U133A.CEL JD0431.ALL.v5.U133A.CEL JD0252.ALL.v5.U133A.CEL JD0188.ALL.v5.U133A.CEL JD0272.ALL.v5.U133A.CEL JD0289.ALL.v5.U133A.CEL JD0407.ALL.v5.U133A.CEL JD0257.ALL.v5.U133A.CEL JD0095.ALL.v5.U133A.CEL JD0226.ALL.v5.U133A.CEL JD0154.ALL.v5.U133A.CEL JD0206.ALL.v5.U133A.CEL JD0102.ALL.v5.U133A.CEL JD0129.ALL.v5.U133A.CEL JD0192.ALL.v5.U133A.CEL JD0260.ALL.v5.U133A.CEL JD0036.ALL.v5.U133A.CEL JD0381.ALL.v5.U133A.CEL JD0203.ALL.v5.U133A.CEL JD0246.ALL.v5.U133A.CEL JD0274.ALL.v5.U133A.CEL JD0334.ALL.v5.U133A.CEL JD0186B.ALL.v5.U133A.CEL JD0185B.ALL.v5.U133A.CEL JD0332.R.ALL.v5.U133A.CEL JD0168.B.ALL.v5.U133A.CEL JD0297.R.ALL.v5.U133A.CEL JD0300.RR.ALL.v5.U133A.CEL JD0291.RR.ALL.v5.U133A.CEL Gene List Index ES Number of genes: 12930 (in list), 53 (in gene set) ES = −0.475 NES = −1.73 Nom. p−val= 0.00314 FWER= 0.962 FDR= 0.134