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Golimumab Drug Information

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Golimumab Drug Information Golimumab Drug information Golimumab can be used to treat rheumatoid arthritis and psoriatic arthritis. Golimumab should effectively Golimumab won’t be prescribed if: treat your condition, and stop it • your arthritis isn’t active causing damage to your joints. It • you haven’t tried standard has been tested and has helped treatments appropriate for many people. However, as with your condition first all drugs some people will have • you have an infection. side-effects. This leaflet sets out what you need to know. You may not be prescribed golimumab if you’ve had or have: What is golimumab • repeated infections and how is it used? • multiple sclerosis (MS) • cancer In rheumatoid arthritis and some • a serious heart condition other inflammatory conditions, • scarring of lung tissue (lung fibrosis). too much of a protein called TNF is produced in the body, causing You’ll have a chest x-ray and a inflammation, pain and damage to test to check whether you’ve ever the bones and joints. Anti-TNF drugs been exposed to tuberculosis such as golimumab (trade name: (TB). You may need treatment for latent (asymptomatic) TB Simponi) block the action of TNF before starting golimumab. and so reduce this inflammation. They’re not painkillers, but they can You may also be checked for modify the disease and should start to previous hepatitis infection, as improve your symptoms after about golimumab may increase the risk 12–14 weeks (after three or four doses). of hepatitis being reactivated. Golimumab can be prescribed by a consultant rheumatologist for: • rheumatoid arthritis • psoriatic arthritis Golimumab is an • axial spondyloarthritis (including ankylosing spondylitis) anti-TNF drug, which can modify There are national and local the underlying guidelines that determine when golimumab can be used and these disease process. vary depending on the condition. You’ll probably have further checks while you’re on golimumab to monitor its effects. If golimumab isn’t suitable for you your doctor will discuss other This drug can treatment options with you. reduce inflammation, When and how do I which in turn take golimumab? reduces the pain. Golimumab is given once a month by injection under the skin (subcutaneous injection), usually into your thigh, tummy or upper arm. It comes in a 50mg ‘pen-like’ device or a syringe which you or a relative can learn to use. Possible risks and side-effects If you forget a dose, you should take it The most common side-effects as soon as you remember. If it’s more are reactions at the injection site, than two weeks late, you should start such as redness, swelling or pain. a new schedule from the date you These reactions aren’t usually take the delayed dose. Otherwise, you serious. Regularly changing the can keep to your original schedule. injection site will help reduce NEVER inject a double dose to the chances of this irritation. make up for a forgotten dose. Golimumab affects your immune If you weigh more than 100 kg system, so you may be more likely (approximately 15 stone 10 lb) and to develop infections. You should you’ve not responded to golimumab tell your doctor or rheumatology after three or four doses, your doctor nurse straight away if you develop may increase your dose to 100 mg per a sore throat, fever or other signs of month for three or four injections. infection, or if you have any other Because it’s a long-term treatment it’s new symptoms that concern you. You important to keep taking golimumab should see your doctor straight away (unless you have severe side-effects): if any of your symptoms are severe. • even if it doesn’t seem to You should also see your doctor if be working at first you develop chickenpox or shingles • even when your symptoms or come into contact with someone start to improve (to help keep who has chickenpox or shingles. These the disease under control). infections can be severe if you’re on golimumab. You may need antiviral treatment, and your golimumab may be stopped until you’re better. Rarely, people may experience an allergic reaction. Contact your It may take healthcare team if you think 12-14 weeks you may be having an allergic for this drug to reaction. If the reaction is severe the drug will have to be stopped. take effect. The long-term side-effects of golimumab aren’t yet fully understood because it’s a relatively new drug. Anti-TNF drugs have been associated with some types of skin cancer – these can be readily Taking other medicines treated when diagnosed early. Golimumab is often prescribed Research so far hasn’t shown an along with other drugs, including increased risk of other cancers. methotrexate. Check with your doctor Very rarely, golimumab can cause before starting any new medications, a condition called drug-induced and mention you’re on golimumab if lupus, which can be diagnosed with you’re treated by anyone other than a blood test. The symptoms include your usual rheumatology team. a rash, fever and increased joint pain. • You can carry on taking a If you develop these symptoms you non-steroidal anti-inflammatory should contact your rheumatology drug (NSAIDs) or painkillers if team. This is usually mild and clears needed, unless your doctor up if golimumab is stopped. advises otherwise. • Don’t take over-the-counter or Reducing the risk of infection herbal remedies without discussing this first with your healthcare team. • Try to avoid close contact with It’s recommended you carry a people with severe active infections. biological therapy alert card so • For advice on avoiding infection anyone treating you will know from food, visit: http://www.nhs. that you’re on golimumab – uk/Conditions/Food-poisoning/ you can get a card from your Pages/Prevention.aspx rheumatology department. Vaccinations Fertility, pregnancy It’s usually recommended that and breastfeeding people on golimumab avoid If you’re planning to try for a baby, live vaccines such as yellow if you become pregnant, or if fever. However, sometimes a live you’re thinking of breastfeeding vaccine may be necessary – for talk to your rheumatologist. example rubella immunisation in Guidelines state that most anti-TNF women of childbearing age. drugs can be taken in pregnancy. If you’re offered shingles vaccination There is, however, no evidence on (Zostavax) it’s best to have it which to advise about the use of before starting golimumab. golimumab during pregnancy. Since it Shingles vaccination isn’t is very similar to other anti-TNF drugs recommended for people who it is unlikely to be harmful if taken in are already on golimumab. the first three months of pregnancy as it does not cross to the baby. Pneumococcal vaccine (which gives protection against the most If you were to take it throughout common cause of pneumonia) and pregnancy, particularly in the last yearly flu vaccines are safe with three months, then your baby should golimumab and recommended. not have a live vaccine until they are at least seven months of age. Having an operation If you are also taking methotrexate this drug should be stopped three Talk this over with your specialists. months before trying for a baby. It’s likely you will be advised Guidelines now state that men don’t to stop golimumab for a time need to stop taking methotrexate before and after surgery. when trying to father a child. We don’t know how golimumab Alcohol might affect men trying to father There’s no known interaction a baby, though other anti-TNF between golimumab and alcohol. drugs can be used in this situation. If you’re also taking methotrexate, Talk to your rheumatologist. you should stay well within It’s not known whether golimumab government guidelines for adults of may pass into your breast milk. no more than 14 units of alcohol per Other anti-TNF drugs may be used week. Your doctor may advise lower with caution in breastfeeding so limits. Methotrexate and alcohol can you should talk with your doctor interact and damage your liver. whether to use golimumab while breastfeeding. Arthritis Research UK Thank you for supporting Arthritis works to improve the Research UK. With your generosity we can keep doing our vital work. quality of life for people To donate visit with arthritis so that www.arthritisresearchuk.org/donate they can say they are in control, independent and recognised. We’re dedicated to funding research into A team of people contributed to this booklet. It the cause, treatment and cure of arthritis was written by Dr Elizabeth Rankin and updated so that people can live pain-free lives. by Dr Alison Jordan and Dr Ian Giles. An Arthritis Research UK medical advisor, Dr Neil For more expert information visit our Snowden, is responsible for the content overall. website or if you would like to tell us what you think about our booklets email Please note: we have made every effort to [email protected] ensure that this content is correct at time of or write to the address below. publication, but remember that information about drugs may change. This information Arthritis Research UK sheet is for general education only and does not list all the uses and side-effects associated Copeman House with this drug. St Mary’s Gate Chesterfield S41 7TD 0300 790 0400 www.arthritisresearchuk.org @ArthritisRUK /arthritisresearchuk Date published: 2015. Registered charity in England and Wales no. 207711, Scotland no. SC041156. ©Arthritis Research UK 2015 A Company registered in England and Wales. Limited by Guarantee no. 490500. 2279/D-GOL/15-1.
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