Anti-PPP4C (Aa 290-301) Polyclonal Antibody (DPABH-05441) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-PPP4C (aa 290-301) polyclonal antibody (DPABH-05441) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Immunogen Synthetic peptide: C-PQETRGIPSKKP, corresponding to C terminal amino acids 290-301 of Human PPP4C

Isotype IgG

Source/Host Goat

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB, ELISA, IHC-P

Format Liquid

Size 50 μg

Buffer pH: 7.30; Constituents: 0.5% BSA, 99% Tris buffered saline

Preservative 0.02% Sodium Azide

Storage Store at 4°C or -20°C long term. Avoid repeated freeze / thaw cycles. Store undiluted.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name PPP4C protein phosphatase 4, catalytic subunit [ Homo sapiens ]

Official Symbol PPP4C

Synonyms PPP4C; protein phosphatase 4, catalytic subunit; protein phosphatase 4 (formerly X), catalytic subunit; serine/threonine-protein phosphatase 4 catalytic subunit; PP4; PPX; protein phosphatase X; catalytic subunit; PP-X; protein phosphatase X, catalytic subunit; PP4C; PPH3; PPP4;

Entrez Gene ID 5531

Protein Refseq NP_002711

UniProt ID A0A024R625

Chromosome Location 16p11.2

Function NF-kappaB-inducing kinase activity; hydrolase activity; metal ion binding; protein binding; protein serine/threonine phosphatase activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]