Biotech Guide Baden-Württemberg Biotech Companies in the South-West of Germany BIOPRO Baden-Württemberg

Baden-Württemberg‘s Centers of Excellence

University of Excellence

Mannheim Heidelberg

Karlsruhe Stuttgart

Tübingen Reutlingen Hechingen Ulm

Freiburg Biberach Tuttlingen

Konstanz Contents

Your Guide to the Biotech Industry of Baden-Württemberg 2

Fields of Action 19

Company Profiles 27

Biotech Company Overview 145

Imprint 153

1 BIOPRO Baden-Württemberg

Foreword

sector. The red biotechnology sector, the fact that the healthcare industries – the pharmaceutical industry and the medical red biotechnology sector, pharma industry technology sector together form what are and medical technology sector – face fierce known as the healthcare industries which, international competition. as manufacturing sectors, are an important part of the healthcare industry as a whole. In the field of bioeconomy, the process of Further cooperation between the three sec- integrating biotechnology into the applica- tors is expected to provide additional impul- tion sectors is still in its infancy in Baden- ses for innovative products and services. Württemberg. The major focus is still on laying research foundations. As a state-wide The Baden-Württemberg government agency, it is our task to inform industry has recognised this potential and has and society of the new possibilities and expanded the activities of BIOPRO Baden- to develop perspectives. This creates the Dr. Ralf Kindervater Württemberg. In future, we will serve as unique chance to resolve in a “living lab” CEO BIOPRO a central point of contact for all sectors the chicken-egg dilemma between product Baden-Württemberg GmbH within the healthcare industries. Today, it is development and market. Many ideas rela- no longer just a case of informing the public ted to the field of bioeconomy such as the Biotechnology has come of age. As a cross- about the innovative power of biotechno- manufacture of biobased plastics are being sectoral technology, biotechnology contri- logy and increasing public acceptance for developed comparatively slowly as demand butes to further developments and innova- biotechnology, but also about analysing the is not yet high enough. On the other side tion in the traditional sectors “pharmaceu- problems of the entire healthcare industry of the coin, the market is underinformed tical industry” and “medical technology”. and developing measures to strengthen the about the possibilities and new materials This process will continue and is much industry in Baden-Württemberg in close within the bioeconomy and is therefore not more advanced in the pharmaceutical cooperation with industry associations. yet driving the development of innovative industry than in the medical technology Such action is necessary in view of the products and services forward. However,

2 people’s growing sustainability awareness Fields of activity: is leading to a change. At the same time, knowledge has increased considerably and the industry is now aiming to become not only sustainable, but also better. The Innovation support Business development support Business start-up services industry’s goal is not only to advance materials and processes that are based on new renewable resources and are on the point of replacing those made from fossil materials, Location marketing Area and cluster development Public relations work but also to produce materials with new, improved properties. Another effect is that completely different economic systems behalf of BIOPRO; the survey takes into nies with up to 50 employees generated that return to focussing more effectively on account classical biotechnology companies around 25% percent of this amount in 2010. regional substance flows can be developed. as well as biopharmaceutical manufactu- This also contributes to sustainability. rers and companies active in the fields of The present BiotechGuide Baden- bioinformatics, diagnostics and analytics Württemberg provides comprehensive As a cross-sectoral technology, biotech- and using state-of-the-art biotechnology information about biotechnology compa- nology remains of particular importance. methods. 123 datasets of companies who nies in Baden-Württemberg. It provides At present there is hardly any problem in had previously submitted information to customers, cooperation partners, investors the fields of health, environment, climate, the Baden-Württemberg Statistics Office and other people interested in biotechno- food and energy that cannot be solved were included in the survey; the number logy with information that facilitates the sustainably with biotechnology. of non-existing records was not estimated. search for and identification of suitable The analysis showed that the sector was cooperation partners in the region. According to our research, Baden-Württem- dominated by micro and small companies; berg is currently home to 159 active bio- 98 companies, i.e. around 80% of all biotech I hope that you will find this information technology companies. In 2010, Baden- companies, employed fewer than 50 people. useful. Please do not hesitate to contact Württemberg biotechnology companies Companies with more than 250 em ployees us should you need further assistance or generated taxable revenues of 3.5 billion generated around 87% of overall taxable have any queries. euros with 21,669 employees subject to revenues. The cumulated revenues of small- social security deductions. These figures and medium-sized companies, i.e. those With best wishes, are the result of an analysis carried out by with up to 250 employees, amounted to Dr. Ralf Kindervater, the Baden-Württemberg Statistics Office on around 441 million euros in 2010. Compa- CEO BIOPRO Baden-Württemberg GmbH

3 BIOPRO Baden-Württemberg

Foreword

Demographic change, social inequality, position by creating the right condi- energy- and resource scarcity, climate chan- tions for effective research institutions ge: Baden-Württemberg is excellently posi- and innovative companies as well as tioned to find answers to these major 21st strengthening the cooperation between century challenges, and at the same time science and industry. secure for itself competitive advantage. The Baden-Württemberg government Baden-Württemberg is the most innova- gives great importance to promoting bio- tive region in Europe. There is virtually technology, as pharmaceutical technology no other European region where so and biotechnology have the potential much money flows into research and to generate huge progress in the areas development as in Germany’s southwest. of medicine and therapy. Moreover, bio- Baden-Württemberg is a pretty suc- technology provides solutions that con- cessful competitor for research funds. tribute to avoiding the use of animals for It obtains a large number of European Nils Schmid, MdL the testing of pharmaceuticals. Research Council grants and has achie- Deputy Minister President and ved best results in the German govern- Minister of Finance and Economics Biotechnology will also play a key role mental Excellence Initiative. of Baden-Württemberg in the transition from fossil to renewable energy resources. Biotechnology is key The Baden-Württemberg government in the non-polluting and resource-saving contributes to consolidating this strong conversion of raw materials. Research must

4 lay the foundations for such applications. opportunities. The VC-BW Netzwerk für The Ministry of Science, Research and the Beteilungskapital draws the attention of Arts launched a bioeconomy initiative in international investors to high-tech start- spring 2012 to support the work of Baden- ups in Baden-Württemberg. Württemberg research institutions. At present, bioeconomy is mainly researched And last but not least, BIOPRO Baden- at universities, but we expect a larger Württemberg GmbH: An institution that number of companies to become involved carries out extremely valuable work. The in the issue as a consequence of the drive agency, jointly financed by the Baden- towards sustainable production processes. Württemberg Ministry of Finance and Economics and the Ministry of Science, Courageous entrepreneurs who turn Research and the Arts, supports companies innovative ideas into businesses are an and research institutions, represents the indispensable part of a dynamic company state on the national and international level landscape. Here too, Baden-Württemberg Theresia Bauer, MdL and provides important impulses for the is breaking new ground with a special Minister of Science, further development of the state’s scien- start-up initiative: EXI start-up vou- Research and the Arts of tific and economic activities, particularly chers, which are funded by the Baden- Baden-Württemberg in view of its new focus on the healthcare Württemberg Ministry of Finance and industries and the bioeconomy in 2013. We Economics, enable young entrepreneurs would like to express our immense gratitu- to make use of extensive coaching de to BIOPRO for the work they do.

5 BIOPRO Baden-Württemberg

BIOPRO The BIOPRO Baden-Württemberg GmbH Baden-Württemberg GmbH represents Germany’s best performing state in Breitscheidstr. 10 the biotech/life sciences sector. As a 100 % state- D-70174 Stuttgart owned, non-profit organisation, BIOPRO Baden- Phone: +49 (0) 711/21 81 85 00 Württemberg GmbH promotes biotech companies Telefax: +49 (0) 711/21 81 85 02 in all fields of application of modern biotechnology [email protected] in Baden-Württemberg. BIOPRO promotes and www.bio-pro.de supports the two strategic priorities „health“ and „bioeconomy“ by targeting areas such as biobased Contact person: materials, biomedical engineering, environment, Württemberg and its research institutions, techno- Dr. Ralf Kindervater bioenergy and biopharmaceuticals. logies, and companies known around the world. With its Internet portal, the BIOPRO Employees: 12 Specific measures to promote the economy, loca- Baden-Württemberg GmbH provides current tion marketing, and broad public relations work information and comprehensive background Services: are the main focus of our activities. In addition, our knowledge on biotechnology and the life sci- • Public relation work task is to promote and market science and research ences for target groups such as science, • Area and cluster development resources from universities, technical colleges and industry, culture, and the media. You can find • Location marketing research institutes. With strong com petences and the Internet portal at www.bio-pro.de. • Business development support direct contact with experts in the Baden-Württem- • Innovation support berg-based network, the BIOPRO Baden-Würt- The activities of the BIOPRO Baden-Württemberg • International networking temberg GmbH is available as the primary contact GmbH significantly strengthen the science and • Business start-up services for companies in all phases of development – from business location of Baden- Württemberg. The the foundation to financing or recapitalisation. aim is to start a movement which will allow all companies in the state to position themselves International relations to biotechnology clusters internationally and generate the best possible are being formed and used to make Baden- growth in synergetic surroundings.

6 Baden-Württemberg International - Our Support Services Baden-Württemberg Your one-stop agency on the way to success. Settling in a new region involves having to deal International Agency for Interna- Baden-Württemberg International (bw-i) is the with a wide variety of questions and obstacles. tional Economic and Scientiﬁc competence centre for the internationalisati- Baden-Württemberg International (bw-i) sup- Cooperation on, promotion and development of business, plies the answers and helps you overcome the Haus der Wirtschaft science and research of the State of Baden- obstacles – quickly and easily, based on local Willi-Bleicher-Str. 19 Württemberg. We lend support to domestic expertise and knowledge. D-70174 Stuttgart and foreign companies, clusters and networks, Phone: +49 (0) 711/2 27 87 0 research institutions and universities by serving • Provision of general information on Telefax: +49 (0) 711/2 27 87 22 as the central first-point-of-contact in all que- Baden-Württemberg as a location for [email protected] stions relating to internationalisation. business and science, as well as specific www.bw-i.de location and structural data. www.bw-invest.de Baden-Württemberg: Where ideas work. • Supply of general information on the legal There are many good reasons why Baden- framework and social insurance. Regional office in: Württemberg is a leading business location • Identification of suitable business and Nanjing, Province of Jiangsu, within Europe: scientific partners for your company. PR China • Attractive market, strategically located • Identification of potential sites and for expansion within the EU organization of site visits in cooperation Employees: 55 employees • Innovation region No. 1 in Europe with regional and local business-promotion • Networked business structure for agencies. Business Units: innovative industries • Support with administrative procedures. • Branches, Technologies • Highest manufacturing density of any • Gateway to all actors in the field of business and Innovation German state promotion and development, such as tech- • Science, Research and the Arts • Number one export state among the nology-oriented industrial institutions and • International Economic Relations noncity states of Germany sector-specific networks. • International Projects • Largest investor in research and development • Business Location among German states Baden-Württemberg • One of the highest densities of research facilities and number of patents among German states • Highest percentage of employees working in high-tech industries in Germany • Lowest unemployment rate in Germany • Excellent quality of life

7 BIOPRO Baden-Württemberg

BioRegion Freiburg BioRegion Freiburg — a dynamic region c/o Technology Foundation within the BioValley BioMed Freiburg Rathausgasse 33 The BioRegion Freiburg is a partner in the D-79098 Freiburg tri-national BioValley network which pools Phone: +49 (0) 761/38 81 12 01 the biotechnology potential of the centres of Telefax: +49 (0) 761/38 81 12 99 Freiburg (D), Basle (CH) and Strasbourg (F). [email protected] www.bioregion-freiburg.de The region is known for its excellent and highly diverse research and company lands- Contact person: cape. This takes in the University of Freiburg, Dr. Bernd Dallmann with its unique Faculty of Engineering, one of Dr. Michael Richter Germany’s biggest university hospitals, the Max Planck Institute for Immunobiology, the Tumor the Foundation are the City of Freiburg, the Production range/Services: Biology Center as well as five Fraunhofer University of Freiburg, the Chamber of Industry • BioTechPark Freiburg with lab Institutes, including the Fraunhofer Institute and Commerce Southern Upper Rhine, the and office space for biotech- of Physical Measurement Techniques, which Association of Industrial Enterprises Baden e.V., nology companies works on bioanalytics. the Sparkasse Freiburg – Nördlicher Breisgau • Coordinating and networking “Centers of Excellence” have sprung up in the and the Chamber of Handicrafts of Freiburg. • Support in economic areas of biomimetics, cell and developmental The board of management is located at the development biology, immunology, oncology, nanotech- economic development agency of the city of • Consulting nology, plant biology, tissue engineering and Freiburg. systems biology as well as neurotechnology. Fields of action: Particular mention should be made of the As the central coordination point for the • Laboratories high-performance technology transfer from the BioRegion Freiburg, the Technology • Biotechnology services University of Freiburg, whose portfolio takes Foundation Freiburg offers a broad range of • Biotechnology location in all the eminent high-tech companies. With services for example more than 100 biotech companies, including • Advice in all matters regarding business 40 which are R&D companies, the BioRegion foundation and settlement Freiburg is one of the most dynamic German • Provision of contacts to financial service biotech regions. providers, authorities etc. • Location marketing The Technology Foundation BioMed Freiburg • Management of the BioTechPark Freiburg was set up in 1996 as a central network for the • Support in finding cooperation partners. region by political, research and economic interests with the aim of creating secure jobs. The regional private equity company of the The Foundation also manages the German Sparkasse Freiburg – Nördlicher Breisgau is also BioValley coordination. The members of highly committed to the field of biotechnology.

8 BioTechPark Freiburg – a launching pad BioTechPark Freiburg for biotech companies Engesserstr. 4a–b D-79108 Freiburg The Technology Foundation BioMed Freiburg Phone: +49 (0) 761/50 31 92 0 runs the BioTechPark Freiburg, which offers Telefax: +49 (0) 761/38 81 12 99 optimum start-up and working conditions for both young and established biotechnology www.biotechpark.de companies. • 30,000 m² available space in the Innovation Contact person: Centre of Freiburg Dr. Michael Richter • 4,000 m² of subsidized space for start-up companies Services for the companies: • Low start-up rents — available for a period of • Advice in all matters regarding seven years business foundation and • Contracts for an unlimited period settlement e.g. in • Individual design of the rooms according to • conceptualisation the specific demands of the companies At the same time, the Foundation has a • strategy • Possibility to expand within the same scientific advisory board which decides on the • financing location companies that are to be admitted to the • marketing • Fully equipped Start-up laboratory BioTechPark Freiburg. • Contact with the authorities, etc. • Support in finding cooperation partners • Integration into the network BioRegion Freiburg and BioValley

9 BIOPRO Baden-Württemberg

BioRN Network e.V. Rhine-Neckar Biotech Cluster Beyond that, more than 80 service providers Im Neuenheimer Feld 582 for the biotech industry are located in the D-69120 Heidelberg The German Biotech Cluster Rhine-Neckar region. Phone: +49 (0) 6221/64 92 20 (BioRN) around the cities of Heidelberg, Telefax: +49 (0) 6221/64 92 215 Mannheim, Ludwigshafen and Darmstadt In the 2008 Leading-Edge Cluster Competition [email protected] has grown into one of Europe’s leading bio- the BioRN cluster was distinguished as one of www. biorn-network.org technology clusters. The region is home of of Germany’s most significant high tech regi- Contact person: numerous internationally renowned research ons by the Federal Ministry of Education and Sibylle Geilenberg institutes such as the European Molecular Research (BMBF) and was awarded grants of Biology Laboratory (EMBL), the German 40 million euro for developing the cluster into Production range/Services: Cancer Research Centre (DKFZ), and Europe’s prime location for medical biotech- Activities: the institutes and hospitals of Heidelberg nology in the coming years. • Fostering collaboration and University. Research at these institutes technology transfer between covers all aspects of cell and molecular bio- The BioRN Cluster Management, a public- public research institutions logy and molecular medicine. Competences private partnership, was founded in 2008 and private companies in cell culture and screening technolo- by the BioRN Network e.V. association to • Promoting the development gies are concentrated at the Mannheim foster the cluster‘s network, to develop the of the regional infrastructure University of Applied Sciences. Together, region and to market the cluster worldwide. for research and development more than 3,000 scientists in research insti- The company aims at bringing innovation • Connecting the Biotech Clus- tutions are working in biotechnology-related into society and expanding the industrial ter Rhine-Neckar with other areas. infrastructure. Partners are the Heidelberg innovation hubs world-wide Technology Park, the Rhine-Neckar Chamber The cluster is supported by international of Industry and Commerce and the Rhine- Services for members: companies in the biomedical and pharma- Neckar Metropolitan Region. • Access to a strong regional and ceutical/chemical sectors such as Abbott and international biomedical network BASF in Ludwigshafen, Becton Dickinson in • Free or discounted access to Heidelberg, Merck in Darmstadt, and Roche regional networking events Diagnostics in Mannheim. Thanks to the • Public relations support for com- excellent research environment and strong panies and research institutions support for startup companies in the mid- • Information about activities 1990s, about 80 innovative biotech compa- in the BioRN Cluster, partner nies with own R&D have settled in the regi- regions and the German bio- on. Many of these companies are involved tech landscape in developing and commercializing new pro- • Contact point for biotech ducts and technologies for the diagnosis and associations, government and therapy of human diseases, especially cancer, funding organizations cardiovascular and infectious diseases, and The logo „Invented in Germany“ stands for Leading- diseases of the immune and nervous systems. Edge Clusters (© BMBF)

10 Technologiepark Heidelberg

GmbH Marktplatz 10 D-69117 Heidelberg Campus Office: Im Neuenheimer Feld 582 D-69120 Heidelberg Phone: +49 (0) 6221/5 02 57 10 Telefax: +49 (0) 6221/5 02 57 11 The Technology Park Heidelberg growth of this high-tech location by offering com - [email protected] With its 80,000 square metres of rental space at prehensive support services and active networ- www.technologiepark-heidelberg.de five different locations, more than 80 local compa- king. It initiates and promotes local, national and nies and research facilities, Heidelberg Technology international networks, facilitates cooperation be- Contact person: Park is one of Germany’s most important biotech- tween science and business, supports technology Dr. André H.R. Domin, CEO nology centres and a world leader. The recently- transfer in established companies and startups, opened fifth site is part of Heidelberg’s new acquires external firms, offers lobbying services in Services: Bahnstadt district, where housing and high-tech national and international associations and serves • Helping Start-Ups and SMEs in go hand in hand in an attractive neighbourhood. as a contact for local municipal authorities and the life science sector The so-called Skylabs facility offers 20,000 square federal ministries. The International PartnerPort • Renting office and lab space metres of flexible office and laboratory space. At of Heidelberg Technology Park allows a simple • Financing the Technology Park, about 160 associated mem- and flexible presence on the German market. The • Management and marketing bers support the development of biotech compa- abundance of services is further demonstrated by • Legal affairs nies in the prosperous Rhine-Neckar metropolitan a multimedia conference centre, as well as parti- • Conference services and organiza- region. The city of Heidelberg and the Rhine- cipation in EU projects to promote collaboration tion of networking events, e.g. • “TP-Lunch Lectures”: seminars Neckar Chamber of Commerce are the corporate between European bioregions. Since its foundati- about current topics members of the Technologiepark Heidelberg on in the year 1984, the Technology Park’s mix of • “TP-Forum” for participants from GmbH. The Technologiepark Heidelberg GmbH biotechnology, medical technology, information science, business and politics is the central contact for all companies and coope - and communication technology and environmental • “TP-Apero”, monthly informal rating research institutions. Furthermore, Techno- technology has made it a vital source of inspira- meetings of tenants and logiepark Heidelberg GmbH promotes the rapid tion in connecting science and business. The Hei - associated members delberg University and renowned research institu- • Vivid networking via national tes such as the European Molecular Biology Labo - and international associations, ratory (EMBL), the German Cancer Research Cen - congresses and meetings ter (DKFZ), the Centre for Molecular Biology • Corporate Rates (ZMBH) as well as the University of Heidelberg’s • International PartnerPort: a Soft Biochemistry Centre (BZH) and the Max Planck Landing Facility Institute for Medical Research make up a fertile concentration of life sciences.

11 BIOPRO Baden-Württemberg

BioLAGO e.V. life science network Blarerstr. 56 D-78462 Konstanz Phone: +49 (0) 7531/28 42 72 2 Telefax: +49 (0) 7531/28 43 10 6 [email protected] www.biolago.org

Contact person: The executive committee of BioLAGO looks back on 5 years of successful networking in the life science sector • Andreas Baur at border-crossing Lake Constance. (© BioLAGO) General Manager [email protected] BioLAGO – Impulse for life sciences at neurs, helps with the realisation of ideas and • Klaus P. Schäfer border-crossing Lake Constance area offers marketable service providers for its mem- Chairman The area of Lake Constance, which has been bers – in short: the strengthening of the conte- [email protected] officially accredited as the fifth and youngest stability of the Lake Constance area as innovative • Michael Statnik BioRegion in Baden-Württemberg in 2005, location in Baden-Württemberg. The connection Public Relations holds a multi-layered life science environ- of research and industry is promoted for the main [email protected] ment with research institutions (among others part by issue-specific projects, annual events and the University of Constance, Biotechnology activities for direct contacts. BioLAGO e.V. has Production range/Services: Institute Thurgau, VIVIT-Insitute Dornbirn) recorded, accompanied and initiated over 75 coo- • Providing consulting as well as internationally successful companies peration projects between its members to date. services to start-ups (such as Takeda, Vetter, GATC Biotech). • Transfer of knowledge and Our Profile technology transfer These institutions and companies teamed up • over 80 equal members in research and indus- • Events with partner organisations from Germany, Switzer- try from 4 countries (Germany, Switzerland, • Public Relations land, Austria and Liechtenstein and created the Austria and Liechtenstein) • Brokering of space border-crossing network BioLAGO e.V. in 2007. • Brokering of contacts Developed from a group of regulars, the cluster professionalised by establishing an office in the technology centre in Constance in the middle of 2008. Supported by public and private partnerships the network promotes the interdisciplinary and international exchange in the domain of life sciences and biotechnology for more than five years now.

Several central services are executed by Business leader at Lake Constance: Europe’s leading specialist for DNA sequencing, GATC Biotech AG is BioLAGO: it connects scientists and entrepre- located in Constance. (© Frank Kühnel)

12 • about 6,000 highly qualified jobs in research campus of pharmaceutical company Takeda and industry recently opened up as a domain for life sci- • thereof 500 scientists in universities and ence, biotechnology and neighbouring High- research institutions Tech companies. On its grounds of around • network areas: health (pharma, diagnostics, 100.000 m², with 15 buildings the campus analytics) and environmental protection offers modern, versatile laboratories and high- grade office spaces. Most of the buildings were Our Mission built in the last ten years. From Start-Up to • providing various services like identification and medium-sized companies – new domiciling support of cooperative projects among members businesses profit from the established and pro- and outside partners lific life-science environment on the campus • creating and developing brand awareness for the and beyond (two universities: University of Lake Constance region as an international hub Constance, Hochschule Konstanz-University for life sciences of Applied Sciences, hospital and institutes). • fostering technology transfer between academia Moreover, a distinct infrastructure with bus and industry and rail connections is located right at the • support and coaching of start-ups and spin-offs campus area. Due to its spatial proximity to the neighbouring states Switzerland, Austria Technology Campus Constance and Liechtenstein, the location is especial- – new home of the life sciences ly attractive for internationally operating The region of Lake Constance is not only businesses. The regional branch network famous for its beautiful scenery and its BioLAGO supports new settling companies in quality of life, it is also a site of innovation the interconnection with the life science envi- with attractive conditions. In Constance, ronment at Lake Constance, which is marked the region’s largest city, the former research by small and medium sized companies.

The new Technology Campus in Constance offers a big variety of modern laboratories. (© BioLAGO)

13 BIOPRO Baden-Württemberg

BioRegio STERN The STERN BioRegion, comprising Stuttgart, Thinking business forward Management GmbH Tübingen, Esslingen, Reutlingen and Neckar Friedrichstr. 10 Alb, is a key center of biotechnology research BioRegio STERN Management GmbH is D-70174 Stuttgart and development in Germany combining the principal point of contact and source of Phone : +49 (0) 711/87 03 54 0 excellent opportunities for young entrepre- advice for biotechnology in the region. STERN Telefax: +49 (0) 711/87 03 54 44 neurs with outstanding research institutions. advises start-ups, established businesses and www.bioregio-stern.de Almost 90 biotechnology companies are esta- research institutions on subjects ranging from [email protected] blished in the STERN BioRegion. More than grant applications and financing options to Contact person: 120 companies from the traditionally strong technology transfer. Dr. Klaus Eichenberg, CEO field of medical technology complete the Employees: 11 picture. It organizes and participates in biotech fairs, promotes networking and offers com- Production range/Services: Excellent transport infrastructure and close prehensive services to all connected with • Information and PR service for proximity to an exceptionally high number of biotechnology in the STERN BioRegion. These young biotech firms renowned research institutes and universities services include advice on various kinds of fun- • Cooperation + networking make STERN BioRegion the ideal location for ding, press and public relations services. Anyone • Regulatory affairs companies of all sizes. More than 30,000 square founding a life science company or working/ • Online jobportal meters of office and lab space are available for researching in the field can profit from these • Information and advice on entrepreneurs and start-up companies in the services which are described in detail on funding options Tübingen-Reutlingen Technology Parcs and www.bioregio-stern.de. • Science communications and the Life Science Center in Esslingen. marketing Creating Synergies • REGiNA – Health Region

14 27 of the Future 32 Interdisciplinary thinking is essential.

79 81

• ELSA - Engineering - 35 Medical technology companies work toge- Bietigheim- 73 Bissingen 51 Backnang 10 57 35 Life Sciences - Automation 30 ther with players in fields as diverse as laser 49 47 76 10 63 48 34 Ludwigsburg

64 Branches Kornwestheim 60 88 and materials research, micro-systems tech-

52 74 51 37 65 80 Waiblingen 14 40 44 48 78 49 35 78 53 45 Leonberg 12 50 36 Schorndorf 42 29 42 Fellbach 56 • Regenerative medicine 27 25 37 63 nology, IT and nanotechnology. There are 22 30 43 29 Stuttgart 26 49 64 23 31 44 77 37 27 38 23 24 32 45 28 38 51 39 66 5 20 15 46 52 29 39 67 70 86 24 33 46 68 82 Esslingen 25 40 58 51 49 71 53 • Medical technology and devices 31 41 33 61 53 83 89 91 more than 120 medical technology compa- 52 50 52 50 81 87 54 Sindelfingen 47 47 69 54 40 72 Göppingen 5 84 2 18 53 Ostfildern 54 Böblingen 28 68 19 47 • Bioengineering 3 Filderstadt 75 nies in the high-tech medtech environment Leinfelden- 76 Kirchheim Echterdingen 85 77 29 73 unter Teck

55 r Nürtingen 1 ka • Automation Herrenberg 27 c 74 of the STERN Region with another 400 in Ne 62 2 3 15 59 9 10 6 8 13 44 19 75 28 6 32 25 32 43 71 4 9 22 26 50 11 18 21 34 55 5 10 14 30 36 Fields of action 12 11 22 35 60 Tuttlingen, where global players in the sector 7 16 15 45 37 69 2 6 19 23 36 42 65 8 Tübingen 8 30 16 31 20 3 28 33 26 16 56 9 17 17 27 38 61 58 4 13 20 27 33 43 56 24 7 18 28 39 54 41 Reutlingen 5 7 34 12 34 44 57 14 8 19 29 41 55 70 14 10 13 48 45 48 28 • Economic development 21 62 59 are just as much at home as their suppliers, Rottenbur g 17 46 66 72 1 46 am Neckar 38 42 24

39 • Services 35 67 90 some of them innovative small and medium- 10

15 20 17 25 6 13 21 18 26 Neckar -Alb 22 1 4 • Support 16 23 sized enterprises whose products attract inter-

Hechingen 31 40 36 43 41

3 14

4 2 7 • Marketing 11 11 national attention. Medical, technical, scien- Balingen 32 12 8 • Events Albstadt tific and industrial expertise is systematically 9 21 27 dovetailed here.

14 TTR Technologieparks

Tübingen-Reutlingen GmbH Gerhard-Kindler-Str. 6 D-72770 Reutlingen Phone: +49 (0) 7121/90 97 99 0 Telefax: +49 (0) 7121/90 97 99 15 ELSA Cluster initiative (Engineering-Life own business will be invited to Science2Start [email protected] Sciences-Automation) Lounges for discussion sessions and impulse www.ttr-gmbh.de talks. They can rely on the assistance of the Contact person: Thomas Dephoff Other key industries in the region besides bio- BioRegio Management GmbH team at all times. Founded 2001 technology are the fields of automation and Space: 22,000 sqm mechanical engineering as well as plant construc- The three best ideas will be awarded a mone- No. of companies: 40 tion. Many companies are automotive suppliers tary prize to be presented at BioRegio STERN’s now looking for other branches to diversify annual summer party – an occasion atten- Laboratories: their sales market. The ELSA Cluster initiative is ded by many decision-makers from business, Molecular Biology, Chemistry, funded by the Baden-Württemberg Ministry of research, politics and the financial sector. S-Laboratories Finance and Economic Affairs and aims at bring- Further information at www.science2start.de ing the life science clusters already working in the Next Airport: Stuttgart, 30 km region together with automation and engineering REGiNA – „Health Region of the Future“ clusters. A number of ELSA cluster events will LSC Esslingen take place to kick off cooperative projects across Regenerative medicine has the potential to revolu- Stadt Esslingen am Neckar branches and to encourage start-ups. tionize medicine for both patients and life science Dept. of Economic Development companies. To speed up the further development Rathausplatz 2 Science2Start - Targeted assistance to trans- of innovative research and the introduction of D-73728 Esslingen am Neckar form ideas into successful companies tailor-made therapy approaches and products on a Phone: +49 (0) 711/35 12-34 14 nation-wide scale, a Users’ Centre for Regenerative Telefax: +49 (0) 711/35 12-55 28 62 In the life sciences, a mine of ideas is waiting Medicine is currently being set up in the REGiNA www.lsc-esslingen.de to be exploited. They lie as yet undiscovered health region encompassing Stuttgart, Tübingen Contact person: Stephan Reichstein in laboratories, students’ rooms and professors’ and the Neckar-Alb region. The Federal Ministry Founded 2000 offices. BioRegio STERN’s Science2Start ideas of Education and Research, BMBF, is sponsoring Space: 2,000 sqm competition brings them to light and helps the this project which promotes cooperation between No. of companies: 5 Laboratories: owners to make a business out of them. researchers, doctors, business companies and the Molecular Biology, S-Laboratories various other branches involved in health care. All taking part will profit and three will win. The internet information portal and a telephone Finance Networks : Each outline will be examined for scientific hotline provide users (both doctors and patients) Life Science Fonds Esslingen excellence and economic potential and this feed- with up to date information on possible applica- back will be placed at participants’ disposal for tions of regenerative medicine. Next Airport: Stuttgart, 15 km further use. Those interested in founding their Further information at www.info-rm.de

15 BIOPRO Baden-Württemberg

BioRegionUlm e. V. Science, education, and industry are equally pharmaceutical products in Europe are pro- Olgastr. 95-101 well-represented in the BioRegionUlm. The duced in the BioRegionUlm. D-89073 Ulm biotech companies of the region focus on the Phone: +49 (0) 731/17 32 24 production of drugs. The BioRegionUlm is Ulm is also a city where business meets with its Telefax: +49 (0) 731/17 35 22 4 Europe’s central location for biotechnological University. The University and academic as well [email protected] production, in particular of pharmaceutical as industrial research institutions offer the ideal www.bioregionulm.de products. More than sixty enterprises from infrastructure for engaging in partnership and an [email protected] biotechnology, life sciences and medicinal engi- effective transfer of knowledge and technology. www.biopharmaxx.de neering have settled in the area between the For example the University of Ulm has enlarged Schwäbische Alb and the Lake of Constance. its life sciences’ field through the construction of Contact Person: two life science buildings where the university’s Dr. Niklas Nold A healthy mixture of established enterprises research excellence is concentrated and networ- of international reputation and start-ups in the king in the different biotech fields is guaranteed. Employees: 3 BioRegionUlm leads to a continuous dynamic development with excellent business figures. A germanwide unique degree specific course Production range/Services: The largest number of genetically engineered in pharmaceutical biotechnology at the • Consulting biotech start-ups • Cooperation between science and biotech-companises • Information services and public relations • Support of young talents

Branches: Life science industry (biotech, diagnostics, pharma, medical engineering)

Fields of action: • Biotechnology services • Biotechnology location • Cluster management

Boehringer employee purifying proteins (Photo: Boehringer Ingelheim)

16 University of Applied Sciences in Biberach Medicine, which is funded under the German BiotechnologieZentrum Ulm in cooperation with the University of government’s Excellence Initiative. (Biotechnology Center Ulm) Ulm (including the doctoral study course) part of the strengthens the biopharmaceutical excellence The dynamic development of the location can be TFU-TechnologieFörderungs in the BioregionUlm. Meanwhile a second put into figures. The BioRegion has shown the Unternehmen GmbH course in industrial biotechnology completes most growth in Germany in the area of pharma- (Technology Promotion Ltd.) Biberach’s study guide in this field. ceuticals. Since 2003 more than 2000 new jobs Sedanstr. 14 were provided. Planned and actual corporate D-89077 Ulm Since 2011 the Boehringer Ingelheim Ulm investments since 2003 come to over 1 bn €. Phone: +49 (0) 731/98 58 80 University Center (BIU) which is also Telefax: +49 (0) 731/98 58 83 45 supported by the government of Baden- The initiative BioPharMaXX is strengthening [email protected] Württemberg continues the extraordinarily the BioRegionUlm as a biopharmaceutical www.tfu.de successful scientific cooperation in the field cluster by networking all players of the value- of pharmaceutical biotechnology in the added chain (diagnostics, pharma, biotech and Contact person: Ulm Bioregion and opens up new strate- medical engineering) to create new products Ulrike Hudelmaier, gies for the Graduate School of Molecular and services for the growing health market. Arina Ingendorf

Employees: 6

Production range/Services: • TFU total area 10,000 m2 Biotechnology Center Ulm ca. 1,500 m2 laboratory-space • attractive renting conditions • reduced operating costs in start-up phase

Fields of action: • Start-ups and young companies find ideal surroundings with suitable laboratories, involve ment in Ulm Science City as well as contact to biotechnology companies in the region

Preparation of a chromatography column.

(Photo: Rentschler Biotechnology)

17 BIOPRO Baden-Württemberg

18 Fields of Action

19 BIOPRO Baden-Württemberg Page Agriculture/Food Analytics Bioinformatics Services Biotechnological Research Contract Production Custom Diagnostics Biotech Environmental Supplier Therapeutics Tissue Engineering Biotechnology White Cells/Cell Lines DNA/RNA Organisms Production Proteins/Peptides

Fields Experts in 29 4base lab GmbH •• • • 30 Acrovis® biostructures GmbH •• • • 31 Affimed Therapeutics AG • Agilent Technologies 32 Sales & Services GmbH & Co. KG ••• ••• • • 33 Agrano GmbH & Co. KG • 34 Aldevron Freiburg GmbH ••• •••• 35 Anoxymer GmbH •• 36 Apara Bioscience GmbH •• •• 37 Ascendis Pharma GmbH •• 38 ATG:biosynthetics GmbH ••• •• • • • 39 Atoll GmbH •• • BERTHOLD TECHNOLOGIES 40 GmbH & Co. KG •••• 41 Biametrics GmbH •• Bioassay-Labor für biologische 42 Analytik GmbH •• • 43 BioCat GmbH ••••• 44 BioChem GmbH •• 45 biomers.net GmbH •• • 46 BIOMEVA GmbH ••• • •• 47 BIOPHARM GmbH •• • •• • 48 BioRépair GmbH •• 49 biosyn Arzneimittel GmbH •• • • • 50 BioTeSys GmbH •• • 51 BioTissue Technologies GmbH •• • 52 BMG LABTECH GmbH •••

20 Page Agriculture/Food Analytics Bioinformatics Services Biotechnological Research Contract Production Custom Diagnostics Biotech Environmental Supplier Therapeutics Tissue Engineering Biotechnology White Cells/Cell Lines DNA/RNA Organisms Production Proteins/Peptides

Fields Experts in 53 Boehringer Ingelheim Biopharmaceuticals • • • •••• 54 CANDOR Bioscience GmbH ••••• • 55 cecolabs UG ••• • 56 CeGat GmbH ••• • • 57 Cellca GmbH ••• • • •• 58 Cellendes GmbH ••• 59 CellGenix GmbH ••• • 60 Cellzome AG ••• 61 CETICS Healthcare Technologies GmbH •••• 62 ChemCon GmbH •• 63 Comprehensive Biomarker Center GmbH ••• • • 64 Computomics GmbH & Co. KG •• • 65 Crinotec GmbH •• •• 66 Curetis AG •• 67 CureVac GmbH •• 68 Cytonet GmbH & Co. KG •• 69 da-cons GmbH data analysis & consulting •• 70 DIARECT AG •• •• DSM Nutritional Products 71 GmbH Grenzach •• 72 EMC microcollections GmbH ••• • 73 ExploSYS GmbH • 74 FRUTAROM Savory Solutions GmbH •• • 75 GATC Biotech AG ••• • 76 Genaxxon BioScience GmbH ••• • •• 77 Gene Bridges GmbH •••••• 78 Genotype GmbH •• •

21 BIOPRO Baden-Württemberg Page Agriculture/Food Analytics Bioinformatics Services Biotechnological Research Contract Production Custom Diagnostics Biotech Environmental Supplier Therapeutics Tissue Engineering Biotechnology White Cells/Cell Lines DNA/RNA Organisms Production Proteins/Peptides

Fields Experts in 79 Glycotope Biotechnology GmbH • •••• • • •• 80 Graffinity Pharmaceuticals GmbH •• • • 81 greenovation Biotech GmbH •• • 82 Greiner Bio-One GmbH •• 83 Hain Lifescience GmbH •• • 84 HB Technologies AG •• • • • 85 Heidelberg Pharma AG ••• • • • 86 HiSS Diagnostics GmbH ••••••• 87 Hydrotox GmbH ••• IBAM GbR Dr. Rainer Knörle & 88 Dr. Peter Schnierle ••• •

ibt- Immunological and 89 Biochemical Testsystems GmbH • •••• • 90 immatics biotechnologies GmbH •• 91 Insilico Biotechnology AG •• •• 92 Jobst Technologies GmbH • ••• 93 Junker Filter GmbH • LABOR DR. MERK & 94 KOLLEGEN GmbH •••• ••• 95 Labor für DNA-Analytik •• • • 96 Logopharm GmbH •••• • • 97 Mediagnost GmbH •••• • • 98 MEDICHEM Diagnostica GmbH & Co. KG •••• 99 Medicyte GmbH •••• menal GmbH Gesellschaft für medizinisch 100 naturwissenschaftliche Laboranalyik •• • • 101 MetaSystems GmbH •• • • •

22 Page Agriculture/Food Analytics Bioinformatics Services Biotechnological Research Contract Production Custom Diagnostics Biotech Environmental Supplier Therapeutics Tissue Engineering Biotechnology White Cells/Cell Lines DNA/RNA Organisms Production Proteins/Peptides

Fields Experts in 102 micro-biolytics GmbH •• • • 103 MicroMol GmbH •••• ••• 104 Multi Channel Systems MCS GmbH •• • • nadicom Gesellschaft für 105 angewandte Mikrobiologie mbH •••• • •

nanoTools Antikörpertechnik 106 GmbH & Co. KG •• 107 npi electronic GmbH •• 108 n-bio GmbH • 109 Oncotest GmbH ••• • ••• 110 PANATecs GmbH ••• • • 111 PEPperPRINT GmbH ••••• • 112 Peptide Specialty Laboratories GmbH •• • 113 PromoCell GmbH •• 114 ProQinase GmbH ••• • • • 115 Q-bios GmbH • •• • •••• 116 ravo Diagnostika GmbH • 117 rent-a-lab Dr. Carsten Tober ••• 118 Rentschler Biotechnologie GmbH ••• • ••• 119 RHEACELL GmbH & Co. KG •• • Roche Diagnostics GmbH 120 Roche Diagnostics Deutschland GmbH ••••• 121 Sciomics GmbH •••• • 122 SEARCH-LC GmbH •• • • 123 Sensovation AG ••• 124 SGS M-Scan GmbH ••• • •• 125 Subitec GmbH ••

23 BIOPRO Baden-Württemberg Page Agriculture/Food Analytics Bioinformatics Services Biotechnological Research Contract Production Custom Diagnostics Biotech Environmental Supplier Therapeutics Tissue Engineering Biotechnology White Cells/Cell Lines DNA/RNA Organisms Production Proteins/Peptides

Fields Experts in 126 SYGNIS Pharma AG ••• 127 SYMBIOSIS •• • •• • 128 SYNIMMUNE GmbH •• 129 Synovo GmbH ••• • • 130 TETEC AG •• 131 TEVA GmbH • 132 TherapySelect GmbH & Co. KG • 133 Thermo Fisher Scientific - Phadia GmbH •• • 134 TICEBA GmbH •• 135 Trenzyme GmbH • • •••• 136 varionostic GmbH •• • 137 VAXIMM GmbH • 138 Vetter Pharma International GmbH • Viscofan BioEngineering 139 a Business Unit of Naturin Viscofan GmbH •• 140 VIVACELL Biotechnology GmbH •• • • 141 WITec GmbH •• 142 Züblin Umwelttechnik GmbH • 143 Zwisler Laboratorium GmbH •• •

24 Definitions of Fields of Action

Agriculture/Food: Companies using diagnostics. Not included are manufacturers food additives, technical enzymes and bio- innovative biotechnological methods in the of laboratory articles such as 96-well plates. fuels with microorganisms, cells or their fields of nutrition and/or agriculture. This constituents. The term can also refer to does not include classical fermentation Environmental Biotech: Companies companies that carry out R&D in this field, technologies that have been used for many using biological systems in technological including the development of bacterial centuries, e.g. for the production of wine methods with the goal of reducing envi- strains. Companies from the field of red bio- and sauerkraut. ronmental stress and saving resources. The technology are not part of this field. companies typically combine knowledge in Analytics: Companies manufacturing pro- bioprocess engineering, applied microbiolo- ducts for laboratory analytics or providing gy and applied engineering to develop and Cells/Cell Lines: Companies active in analytical services, e.g. sequencing, HPLC. use methods for air and waste gas purifica- the field of cells/cell lines, including com- tion, soil decontamination, water and waste- panies that offer cell line development, Bioinformatics: Companies developing water purification or waste treatment. produce biotechnological products using software for application in the life sciences/ cells, develop/offer cell therapies as well biotechnology or providing clients with Suppliers: Companies manufacturing con- as companies that develop/manufacture bioinformatics or IT/IT services for specific sumables and equipment for biotechnolo- products for work involving cells (e.g., cell application in the field of systems biology. gical applications, e.g. reaction vials, centri- cultures); companies that use cells for bio- Not included are software products for use fuges, reagents, kits, antibodies for research technological services or contract research. in medical practices or clinics, e.g. software or diagnostics as well as devices for the ana- for sequence optimisation, modelling of lysis of experiments such as ELISA readers. DNA/RNA: Companies with activities signalling cascades. related to DNA/RNA, e.g., sequencing, Therapeutics: Companies focussed on epigenetics, cloning, therapeutic RNA. Biotechnological services: Companies research, development and production of providing clients with biotechnological products for therapeutic purposes using Production Organisms: Companies using laboratory services, e.g. sequencing, PCR, biotechnological tools, e.g. proteins, pep- cells or microorganisms for the biotechnolo- cloning, analytical methods, cell banks. tides, antibodies. gical production of antibodies/proteins, for example, as well as companies offering cell Contract Research: Companies carrying Tissue Engineering: Companies carrying and strain development for subsequent use out research projects in the fields of biotech- out research or other activities in the field in biotechnological manufacture of products. nology/life sciences on behalf of clients. of regenerative medicine. This includes, for example, the production of cell preparations, Proteins/Peptides: Companies with acti- Custom Production: Companies provi- tissues, and scaffolds that provide structural vities related to proteins/peptides, e.g. com- ding clients with contract production in the support for the attachment of patient cells panies that manufacture and commercialise field of biotechnology, e.g. the production of and subsequent tissue development. proteins/peptides/antibodies or companies primers, proteins. that produce them on behalf of third par- White Biotechnology: Companies ties; companies focussing on research and Diagnostics: Companies providing dia- employing biotechnological methods to production of proteins/peptides or com- gnostic laboratory services and companies manufacture industrial products such as panies that manufacture products for the manufacturing products for use in in vitro organic basic and fine chemicals, food and analysis of proteins.

25 BIOPRO Baden-Württemberg

26 Company Profiles

27 BIOPRO Baden-Württemberg 4base lab GmbH – 4base lab GmbH advanced molecular analysis Aspenhaustr. 25, Postfach 4023 D-72770 Reutlingen 4base lab GmbH was founded in 1996 and Phone: +49 (0) 7121/93 75 57 holds excellent expertises in molecular cloning Telefax: +49 (0) 7121/93 75 58 and gene analysis of human pathogens. As one [email protected] of the first biotech companies in Germany, www.4base-lab.de 4base lab operates its enterprise in compliance with the quality management standard as spe- Contact person: cified by the DIN EN ISO 9001:2000 and is Birgit Blum an accredited testing laboratory in accordance Ultrapure human BAC-DNA and genetic stabi- with DIN EN ISO/IEC 17025:2005. Facilities lity testing are additional services for diagnostic Employees: 10 include S1/L2 labs as well as strictly controlled manufacturers. PCR labs. 4base lab is also approved by regula- Production range/Services: tory authorities to analyse animal samples for 4base lab offers a wide range of molecular ser vices • Custom DNA sequencing epizootic diseases. Since 2006, 4base lab was including Real-Time PCR for the detection of • GMP/GLP compliant services for also authorized by the Regierungspräsidium pathogens in blood, pharmaceuticals, food, water, biopharmaceutical drugs Tübingen to perform GMP compliant services human or insect samples. In 1999, 4base lab (identity, contamination) for biopharmaceutical drugs, especially for achieved a permission of the Paul-Ehrlich-Institut • Biodistribution analysis of innovative RNA-based cancer therapeutics. to use its Hepatitis-C Real-Time assay for virus preclinical biopharmaceuticals detection in blood products. Recently, 4base • Quality surveillance for PCR 4base lab offers an extensive expertise in the lab developed a CE marked kit for the detec- inhibitors in consumables and development and validation of customized tion of Influenza A viruses (incl. H1N1, H5N1) viral contamination qNAT assays. GMP compliant methods for to be used for in vitro diagnostics. Multiplex • CE-Kit for the detection of biodistribution analysis of DNA-/RNA targets detection of Influenza A/B is also avai lable. Influenza A (incl. H1N1, H5N1) in tissue samples, detection of residual vector We also analyse community and environmental • Detection of Borrelia DNA or E. coli DNA in preclinical drugs are samples for presence of lyme-disease-causing DNA in ticks available for the pharmaceutical industry. bacteria utilizing state-of-the-art technology.

Fields of action: • Analytics • Biotechnological Services • Diagnostics • DNA/RNA

29 BIOPRO Baden-Württemberg

ACROVIS® biostructures GmbH Rathausgasse 1 D-89160 Dornstadt Phone: +49 (0) 7348/94 93 280 Telefax: +49 (0) 7348/94 93 278 [email protected] www.acrovis.de

Contact person: Dr. Thomas Haehner ACROVIS® biostructures was founded in Furthermore, ACROVIS® biostructures offers Employees: 7 October 2008. Our aim is to fill in a gap in the the benchmark technology fragment-based drug pharmaceutical value-added chain by rationali- design (FBDD) which is capable of finding novel Fields of action: zing and commercializing the industrial deve- hit structures. • Bioinformatics lopment of drug candidates by using benchmark • Contract Research technology. Depending on the NCE’s research and develop- • Proteins/Peptides ment needs of our clients, ACROVIS® biostruc- • Therapeutics ACROVIS® biostructures assists its clients in the tures offers a variety of services ranging from hit process of developing drug candidates which finding to optimization of a lead structure. Our feature both a highly specific inhibitory activity small molecules show a high inhibitory activity and outstanding pharmacokinetic properties with due to an excellent structural fitting, a high bio- almost zero toxicity. availability and a favorable side effect profile. This molecular properties make the process of drug Our in-house X-ray and NMR research facilities, development more successful. biophysical experiments and state-of-the-art CADD analysis deliver the respective data crucial for the structure-based drug design.

The process of optimization of a chemical compound takes into account the drug target in its essential conformational states.

In this highly complicated and challenging task, our in-house technology platform AcroDyn® is able to detect all the crucial states of a macromolecule. Consequently, the identification and optimization of the drug candidates become highly effective.

30 Affimed Therapeutics AG is a Heidelberg- Afﬁmed Therapeutics AG based clinical stage biotech company develo- Technologiepark ping TandAb antibodies in oncology. TandAbs Im Neuenheimer Feld 582 are human antibodies with excellent binding D-69120 Heidelberg properties and product stability. They are Phone: +49 (0) 6221/65 30 712 bispecific and tetravalent, comprising sole- Telefax: +49 (0) 6221/65 30 777 ly variable domains. TandAbs can bind to www.affimed.com immune effector cells (NK cells or T cells) targeting these cells to the tumor by binding Contact person: to a tumor-associated antigen where these Daniela Treiber immune effector cells display a very potent anti-tumor activity, which warrants further clini- and specific cytotoxic activity. The TandAb cal development. AFM11, a CD19/CD3 TandAb Employees: 37 antibody format promises both increased for the treatment of B-cell lymphomas, such therapeutic potential and superior safety as non-Hodgkin lymphoma (NHL) and acute Production range/Services: profiles compared to monoclonal antibodies. lymphoblastic leukemia (ALL), is in late stage • Biologics/Antibodies Furthermore, when compared to antibody preclinical development and expected to enter fragments and scaffolds, TandAbs show better phase I clinical studies in 2013. Both candidates Fields of action: targeting properties due their bivalent bin- address markets with high medical need and • Therapeutics ding and have a much longer half-life. significant sales potential.

Affimed’s therapeutic pipeline consists of two Affimed was founded in 2000 as a spin-off of TandAb products, AFM11 and AFM13. AFM13, the DKFZ in Heidelberg and employs 37 peo- a CD30/CD16A TandAb, has recently comple. Affimed is backed by a peer group of inves- pleted a phase I clinical trial in relapsed/refrac- tors including Orbimed, Aeris, LSP, BioMed tory Hodgkin Lymphoma patients. The trial Invest and Novo Nordisk A/S and recently established that AFM13 was safe and well tole- closed a Series D financing round with € 15.5 rated at all dose levels and showed meaningful million in September 2012.

31 BIOPRO Baden-Württemberg

Agilent Technologies Agilent Technologies Inc. (NYSE:A) is the Sales & Services GmbH & Co. KG world’s premier measurement company and Hewlett-Packard-Str. 8 a technology leader in communications, elec- D-76337 Waldbronn tronics, life sciences and chemical analysis. The Phone: +49 (0) 800/6 03 10 00 company’s 20,500 employees serve customers Telefax: +49 (0) 69/95 30 79 19 in more than 110 countries. Agilent had net [email protected] revenues of $6.9 billion in fiscal 2012. www.agilent.com/chem Agilent‘s Life Sciences and Chemical Analysis Contact person: Alexandra Nagel (LSCA) group is a world leading provider Branches: USA, Asia Pacific, EMEA of instrumentation, supplies, software and Employees: 20,500 services to life science and chemical analysis Production range/Services: markets. Microfluidics, microarrays Agilent is helping organizations to advance (Catalog & Custom Arrays), LSCA‘s key technology platforms include gas basic research, unlock the genetic causes of microarray scanner, QPCR & chromatographs (GC), liquid chromatographs disease and accelerate the discovery and devel- PCR, automation solutions, (LC), mass spectrometers (MS), microarrays, opment of new drugs. Agilent addresses the bioinformatics, bioconsumables, and microfluidics-based devices. These tech- needs of the entire pharmaceutical value chain liquid chromatography systems, nologies make possible the identification, with solutions for gene expression, proteomics, dissolution, magnetic resonance quantification, and analysis of the atomic, informatics, pharmaceutical analysis (for drug solutions, molecular spectroscopy, molecular, physical and biological properties development, QA/QC, and manufacturing), and mass spectrometry systems, ICP- of thousands of substances and products. regulatory compliance. As the leading provider MS systems, atomic spectroscopy, Agilent LSCA is a world market leader in gas of chemical analysis tools, Agilent develops and gas chromatography systems, UV- chromatography, liquid chromatography, mass markets solutions for the growing environ- visible spectrophotometer, electro- spectrometry, microfluidics and compliance mental, petrochemical, energy, food safety phoresis, X-ray christallography, services, with product and technology leader- and quality, and AgBio markets, and supports data handling, support/services, ship in many areas, including gene expression homeland security with instruments and exper- columns and supplies and proteomics analysis. In the life sciences, tise in biochemical detection and forensics.

Fields of action: • Agriculture/Food • Analytics • Bioinformatics • Diagnostics • Environmental Biotech • Supplier • DNA/RNA • Proteins/Peptides

32 Agrano GmbH & Co. KG Bahnhofstr. 35 D-79359 Riegel am Kaiserstuhl Phone: +49 (0) 7642/67 26 3 Telefax: +49 (0) 7642/67 26 9 [email protected] www.agrano.de Factory premises in Riegel am Kaiserstuhl

Contact person: Expertise in fermentation of microorganisms Jürgen Lamm, Director R&D Agrano GmbH & Co. KG, founded in 1996 Ralf Bredenhöller, Managing Director and located in Riegel am Kaiserstuhl near Freiburg, is specialised in the production of Employees: approx. 50 organic yeast. Today, the company has approximately 50 employees and supplies customers Production range/Services: with organic yeast products around the globe. Through intensive collaboration with colleges and uni- • Organic yeast products for indus- versities, Agrano GmbH & Co. KG can continuously expand its expertise in the research and development trial processing and the organic Agrano GmbH & Co. KG can also look back on of biotechnological processes. specialised trade many years of experience in collaboration with • fermentation on commission external companies during the development and (75,000 l). As all the fermentations are performed • fluidised-bed drying fermentation of special microorganisms. Ideal under sterile conditions and the most stringent • spray granulation conditions prevail in Riegel am Kaiserstuhl for hygiene standards, simultaneous processes are pos- • coating scaling up the biotechnological processes. sible in the various development stages. • agglomeration

For product development, a highly qualified team of Different separators and a vacuum rotary filter are Fields of action: microbiologists, biochemists and process engineers available for further processing. If required, additio- • Agriculture/Food is available. Using various fermenter sizes, the devel - nal down stream processes can be installed. In the opments can take place at laboratory scale (15 l) pilot facility, large product samples can be produ- through to complete production-ready facilities ced for initial market testing.

Sterile fermentation

33 BIOPRO Baden-Württemberg

Aldevron Freiburg GmbH Aldevron provides contract manufacturing Waltershofener Str. 17 and scientific services for antibody generati- D-79111 Freiburg on, protein manufacture and plasmid DNA Phone: +49 (0) 761/45 63 6 0 production. Aldevron Freiburg (formerly Telefax: +49 (0) 761/45 63 6 29 GENOVAC) is a biotechnology company loca- [email protected] ted in Freiburg, in the centre of the European www.aldevron.com BioValley. Our main business is focussed on the generation of custom-made antibodies Contact person: and complementary services as a service for generated a niche in this field. We are the leading Dr. Stefan Lang biotechnology and pharmaceutical companies company in the generation of antibodies by gene- as well as for academic customers. Aldevron tic immunisation. We have a patent-protected Branches: Aldevron in Fargo, ND Freiburg is a daughter company of US based technology that allows us to quickly bridge the and Madison, WI, USA Aldevron LLC. gap between the mass of DNA sequences that have become available to directly identify the Employees: 80 (worldwide) Aldevron Freiburg has established itself in the gene products and to study their function with world market as a company that is well known the help of antibodies. These antibodies have Production range/Services: for its high quality antibodies and has successfully ideal characteristics for diagnostic and therapeutic • Gene synthesis and optimisation applications. • Plasmid manufacturing • Antibody generation (genetic We offer a uniquely broad scope of antibody pro- immunisation, protein/peptide duction services that will progress your research Immunisation) from an in silico concept to a high affinity mono- • Antibody purification, fragmen- clonal with unprecedented speed, cost efficiency, tation, labelling, sequencing and success rate. Our process includes a fully • ELISA development integrated ability to assist in the design, undertake • Protein Expression (E. coli, animal studies, purify targets, and manufacture. insect cells, mammalian cells) As Aldevron’s antibody services facility we have • Antibody catalogue adopted all classical and state-of-the-art delivery methods to optimize the titre and quality of an Fields of action: antibody. Whether your project is a simple study • Biotechnological Services to generate polyclonal antisera, or a complex • Cells/Cell Lines undertaking culminating in the delivery of purified • Contract Research monoclonal antibodies, we are here to help. • Custom Production • DNA/RNA Our long standing experience, know-how, and • Production Organisms track record make us a preferred vendor for • Proteins/Peptides many large pharmaceutical and major biotechnology companies.

34 Botanical Health Ingredients for Anoxymer GmbH Functional Foods and Nutraceuticals Schelztorstr. 54-56 D-73728 Esslingen Anoxymer’s core competence is the bio-assay Phone: +49 (0) 711/90 12 10 90 guided isolation of bioactive natural carbohy- Telefax: +49 (0) 711/90 12 10 99 drate-based compounds from vegetables, herbs [email protected] and fruits for the development and commerciali- www.anoxymer.info zation of botanical health ingredients with clinically proven benefits for the health prevention. Contact person: Wolfgang Neldner Research & Development mercialized as health ingredients with disease In-vivo-assays (CAM-assay and its variations) are preventive properties e.g.: Planox® L for joint Employees: 6 used for the screening of anti-inflammatory, anti- health; Planox® A for digestive health; Planox® oxidative, anti-angiogenic or immunmodulating PG for cardiovascular health; further botanical Production range/Services: bio-activities. Toxic effects can be detected, e.g. extracts for mental performance and weight Standardized plant extracts as embryo-toxicity and mem brane-irritation as well. management are under development. health ingredients for functional Anoxymer also offers its CAM-assay to the phar- foods, nutritional supplements and maceutical industry for the screening of antiangi- Safety-Quality-Efficacy cosmeceuticals ogenic compounds, e.g. recombinant proteins and The ethno-botanical approach and the CAM- peptides, small molecules and natural compounds. assays guarantee for non-toxic extracts without Fields of action: side-effects. All extracts are completely waterso- • Agriculture/Food Products luble, standardized on carbohydrates, clinically • Analytics Various plant extracts (registered as Planox®) tested and adapted to different food matrices are biologically and chemically standardized to which preserve stability and bioavailability of Anoxymins®. These special extracts are com- the bio-active compounds.

35 BIOPRO Baden-Württemberg

Apara Bioscience GmbH Ferdinand-Porsche-Str. 5/1 D-79211 Denzlingen Phone: +49 (0) 7666/88 39 40 Telefax: +49 (0) 7666/88 39 41 [email protected] www.apara-bioscience.de

Contact person: Alexander Häringer Apara Bioscience GmbH

Employees: 5 The major focus of Apara Bioscience GmbH is requirements, whether the order concerns Production range/Services: the high quality synthesis of oligonucleotides 2 or 200 oligonucleotides. Our laboratory team Oligonucleotides and peptides and peptides. deals with customer orders both professionally and reliably. Fields of action: The company was established in January 2003 • Custom Production as a spin-off from Genescan Europe AG, a For further information about the reliable • DNA/RNA merger of four biotech companies, including services offered by Apara Bioscience, please • Proteins/Peptides BIG Biotech GmbH and BioChip Technologies contact us and we will be happy to discuss • Supplier GmbH. Oligonucleotide production was star- your particular requirements. ted by BIG Biotech GmbH back in 1993 which merged with Biochip Technologies GmbH in 2000. Hermann GbR became part of Apara Bioscience GmbH on 1st January 2007. The growth rate of Apara Bioscience GmbH over the last few years has led to increases in staff numbers and to the company itself becoming a limited liability company (GmbH). The managing director, Alexander Häringer, and his team consider themselves to be competent partners for their customers.

Apara Bioscience offers inexpensive conditions and rapid delivery of oligonucleotides and peptides, even for small orders. The expansion of our production capacities has enabled us to respond to individual customer

36 Ascendis Pharma GmbH Ascendis Pharma GmbH Im Neuenheimer Feld 584 Ascendis Pharma is an emerging speciality D-69120 Heidelberg pharmaceutical company which creates impro- Phone: +49 (0) 6221/4 38 53 0 ved, patentable versions of marketed drugs and Telefax: +49 (0) 6221/4 38 53 11 high-value development-stage opportunities. [email protected] The company operates within the therapeutic www.ascendispharma.com Heidelberg, Germany areas of endocrinology, central nervous system, Contact person: cardiology, ophthalmology and infectious diseases. Dr. Harald Rau, CSO Branches: The company is built upon a novel prodrug Palo Alto, CA (USA) technology, called TransCon, which conjuga- Copenhagen, Denmark tes peptides, proteins or small molecules to a Employees: 40 Copenhagen, Denmark carrier molecule in a reversible fashion. This unique reversibility allows an unmodified Production range/Services: active drug to be released (unlinked) in the Ascendis Pharma has built a high value body in a precise, time-controlled fashion, cre- pipeline with focus on endocrinology, ating a long-acting effect. Conventional conju- CNS, cardiology, ophthal mology and Palo Alto, CA, USA gation technologies are unable to achieve this infectious diseases. Using our inno- type of slow-release mechanism because the va tive prodrug tech nology platform carrier molecule cannot de-link from the drug. TransCon, we continue to analyze oppor tunities to develop a sustainable Ascendis Pharma has seven high-value pro- pipeline for the future and to optimize ducts in its portfolio, of which the lead pro- strategic business development value. gram – TransCon PEG hGH – is a superior Proprietary to Ascendis : growth hormone with a once-weekly dosing • TransCon human Growth Hormone regime, and this is part of the company’s spe- • TransCon Paliperidone cialty focus on endocrinology. • TransCon Pramipexole Partnered with sanofi: The company is headquartered in Palo Alto, • TransCon Insulin California and Copenhagen, Denmark. • TransCon Exendin • TransCon Ascendis Pharma‘s research site is located in Insulin/Exendin combination Heidelberg, Germany. Partnered with United Therapeutics: • TransCon Treprostinil

Fields of action: • Proteins/Peptides • Therapeutics

37 BIOPRO Baden-Württemberg

ATG:biosynthetics GmbH Weberstr. 40 D-79249 Merzhausen Phone: +49 (0) 761/8 88 94 24 Telefax: +49 (0) 761/8 88 94 25 [email protected] www.atg-biosynthetics.com ATG is a synthetic biology and biotech compa- optimization, metabolic engineering, signal ny that combines proprietary analytical and syn- pathway analysis, TALE Nucleases, etc.) Contact person: thetic bioinformatics tools and expertise with • Gene synthesis of individual genes and Dr. Hubert Bernauer systems for the design, assembly and expression gene clusters, TALE nucleases, etc. of (multi-)gene and multi-peptide constructs. Employees: 7 ATG offers products and services for R&D Production range/Services: in industrial and medical biotechnology, drug • Toggle multi-protein discovery, molecular diagnostics, metabolic expression kits and bio-engineering, etc. • PepID peptide library generation and expression system • Multi-gene recombineering / expression • Synthetic bioinformatics systems for E.coli, insect and mammalian • Gene and gene cluster synthesis cells (Toggle, MultiLabel) • Tailor-made expression systems for other Fields of action: (micro)organisms based on a modular • Analytics assembly strategy (Toggle) • Bioinformatics • Proprietary multi-peptide library design tool • Biotechnological Services as well as biosystems-based multipeptide library • Custom Production construction and expression system (PepID) • Diagnostics for rationally designed bio-peptide libraries. • DNA/RNA For use in assessing, identifying (mapping) • Proteins/Peptides and verifying peptide epitopes, antibodies, or • White Biotechnology protein-protein-interaction. Applications in R&D for diagnostics and therapy. • Plasmid production and purification • Gene intelligence solution EvoMAG for • Top-notch computational biology solutions/ multi-parametric sequence calculations for analysis for immunomics, metabolomics, complex (artificial) gene/combinatorial gene gene expression analysis in your target cluster design as well as formal and opera- organism of choice, etc. tional optimization of genes, genetic elements • Synthetic biology and bio-engineering and expression cassettes for diverse target/ projecting/consulting from gene design production organisms (for functional enzyme to (multi-gene) expression strategy.

38 Atoll GmbH Ettishofer Str. 10 D-88250 Weingarten Phone: +49 (0) 751/56 12 10 Telefax: +49 (0) 751/56 12 17 0 MediaScout® [email protected] PrePacked Chromatography Columns www.atoll-bio.com

The demand for biopharmaceutical products Contact person: in particular mAbs is increasing rapidly during Tim Schroeder, Dipl.-Ing. the last years. Branches: 1 (USA) The necessity for pharmaceutical companies Atoll GmbH develops manufactures and distri- of being ‘first on the market’ combined with butes MediaScout®, an innovative chromatogra- Employees: 14 the need to cut development costs makes the phic column technology platform for modern application of HTS techniques and pre-packed Downstream Process Development: Production range/Services: chromatography columns in both downstream • MediaScout process development as well as clinical manu- • ‘High Throughput Process Development’ • MiniColumn facturing indispensable. (HTPD) seamless to Pilot Scale • RoboColumn • Identical column hardware for all • MiniChrom Furthermore greater adoption of single-use chromatography media • ValiChrom and disposable systems in biomanufacturing • More than 6 year proven excellence in • MaxiChrom and development is going to require improved column packing • ResiQuot downstream device innovation in particular for • OEM manufacturer for all major resin suppliers ‘ready to use’ chromatography columns. • ISO 2001:2008 certified Fields of action: • Custom Production • Proteins/Peptides • Supplier

39 BIOPRO Baden-Württemberg

BERTHOLD TECHNOLOGIES

GmbH & Co. KG Calmbacher Str. 22 D-75323 Bad Wildbad Phone: +49 (0) 7081/17 70 Telefax: +49 (0) 7081/17 71 00 [email protected] www.berthold.com/bio

Contact person: Bernd Hutter Berthold Technologies vidually optimised optical paths („DOPS“) has been developed which is renowned in the field Branches: For more than 60 years Berthold Technologies, of GPCR research because of its outstanding Germany, Austria, Switzerland, with headquarters located in Bad Wildbad, BRET performance. Italy, France, Belgium, UK, USA, Germany, has developed instruments for ana- Japan, China, India, Australia lytical and biomedical research, for clinical diag- With the NightOWL Berthold Technologies nostics and for environmental monitoring. has been one of the first providers of an ima- Employees: 85 ging system to localise gene expression in The innovative products are characterised by living animals and whole plants. Production range/Services: their longevity, user friendliness and highest • Microplate luminometers sensitivity. Thousands of sold plate readers, The new NightSHADE LB 985 is the first ima- • Microplate fluorometers luminometers and gamma counters are proof ging system fully dedicated to plant research. • Microplate multimode readers of the high quality of the instruments. • Tube luminometers With the Mithras multimode reader for micro- The user is supported by a worldwide network • In vivo imagers plates a unique measurement device with indi- of subsidiaries, distributors and service points. • Gel imagers • Gamma counters • HPLC radio monitors

Fields of action: • Analytics • Diagnostics • Environmental Biotech • Proteins/Peptides

40 Biametrics GmbH is a successful spin-off com- The Biametrics Point-of-need device is designed Biametrics GmbH pany at the University of Tuebingen and serves as a smart solution for your on-site applications. Auf der Morgenstelle 18 as a service provider and know-how carrier at • Allows for detection of any biomolecular D-72076 Tübingen the interface of biotechnology / pharmaceutics, interations Phone: +49 (0) 7071/29 73 04 8 medical engineering and life science analy- • Fast - result can be obtained within minutes Telefax: +49 (0) 7071/29 57 72 sis. The patented Biametrics technology inclu- without need for sample treatment or [email protected] des label-free detection, surface chemistry and thermostabilization www.biametrics.com assay development for the time-resolved analy- • Easy to use - it doesn‘t need to be operated sis of any kind of biomolecular interaction. For by specially trained personel Contact person: collaborations with market-leading companies • Robust and cost-effective - aside from Dr. Florian Pröll Biametrics provides R&D services and licenses point-of-need aplications, it is possible to in the areas of IVD, life-science research, pro- use the device for teaching and educatio- Branches: cess control, and Homeland-Security. Besides nal purposes Life Science Analytics these development services, Biametrics can • Handheld - can be used anywhere where also act as a consultant for the series produc- you would also use a laptop Production range/Services: tion of sensor elements on the basis of label- Biosensors for life sciences and free technologies. Screening Device diagnostics

Based on innovative label-free biosensor tech- Fields of action: nology, Biametrics develops in cooperation • Analytics with / for customers analytical system solutions • Supplier in the areas of

• Life science analytics & research • Screening of biologics • Point of need (PON) applications • In-vitro diagnostics

Point-of-need Device The Biametrics Screening Device offers you the possibility to analyse thousands of different interaction simultaneously. • It supports free scalable DNA, peptide or Protein microarrays • Scalable sample volume from 250 to 1000 μL per measurement • Integrated software for full kinetic evaluation of the biomolecular interaction can be customised towards your needs

41 BIOPRO Baden-Württemberg

Bioassay - Labor für Bioassay GmbH biologische Analytik GmbH Im Neuenheimer Feld 515 Bioassay GmbH is an independent contract D-69120 Heidelberg laboratory, specializing in the development, Phone: +49 (0) 6221/4 33 88 90 validation and routine performance of bioana- Telefax: +49 (0) 6221/4 33 88 99 lytical assays in the area of Pharmacology and [email protected] Toxicology. We carry out qualified analytical [email protected] services on the sound basis of our GMP & www.bioassay-online.de GLP certification, which provides an excellent framework for successful projects and routine Contact person: bioanalysis. Dr. Sven-Michael Cords, COO serves to encourage continuous improvement, Bioassay GmbH specializes in biological assays inspire confidence and reinforce the transpar- Employees: 15 within the framework of the development & ency of our performance. quality control of pharmaceutical and chemical It goes without saying that we handle all Production range/Services: products, and is focussing on potency assays customer-specific data and processes with the • Bioanalytical services under GMP as well as on safety assays under utmost confidentiality. This is an integral part • Potency assays (GMP) OECD guidelines (GLP). of our philosophy. • Safety assays (GMP & GLP) • Assay development The GLP & GMP conform procedure and We combine standardized processes with flex- • Assay validation documentation is the basis for the reliability of ible organization, adapting constantly to the • Assay routine our services. This guarantees the acceptability current needs of the market and our custo- of the data generated in our laboratories as mers. This creates space for the enhancement Fields of action: part of the quality assurance of the products of our service portfolio. Key global players • Analytics undergoing testing. as well as start-up companies in the pharma- • Biotechnological Services ceutical and chemical industries trust in the • Proteins/Peptides The inspection of quality standards carried out experience and dedication of our bioanalytical by regulatory authorities and customer audits experts.

42 BioCat GmbH BioCat GmbH Technologiepark BioCat GmbH is a private company founded Im Neuenheimer Feld 584 in the year 2000. As a true solution provider, D-69120 Heidelberg BioCat supplies innovative products and ser- Phone: +49 (0) 6221/7 14 15 16 vices for life science research in an application- Telefax: +49 (0) 6221/7 14 15 29 and customer-oriented way. [email protected] www.biocat.com The product offering comprises a wide range Contact person: of high-quality research reagents and cutting- Dr. Michael Ehret edge technologies in the fields of genomics, Employees: 13 proteomics and cell biology. For tissue-related applications, tissue microarrays as well as RNA, Production range/Services: cDNA and proteins isolated from a wide vari- Reagents and services for life sci- ety of common and hard-to-obtain tissues are ence research with focus on genomics, proteomics and cell biology available. Fluorescent proteins, a large selection including of antibodies, ELISA kits, cell-based assays, • Tissue microarrays PCR and next generation sequencing reagents • Gene silencing as well as tools for microRNA, epigenetics and • microRNA analysis stem cell research complement the portfolio. • Epigenetics • PCR & qPCR The products and services provided have been • DNA, protein, and cell arrays developed by partners in Canada, Germany, • Libraries & clones (cDNA, ORF, Korea, Russia and the US. They are made BAC, 3’UTR, Promoter) available through BioCat to researchers in • DNA cloning & modification kits academia as well as in pharma and biotech • Sample preparation kits • Antibodies & ELISA kits industry. • Fluorescent proteins • Cell-based assays Moreover, BioCat is aiming at the co-develop- • Apoptosis & signal transduction ment of new products based on innovations • Transcription factor analysis generated in Germany, such as the production • Multiplex cytokine assays of protein arrays by Laser Induced Forward Transfer (LIFT) of proteins onto substrates. Fields of action: • Analytics • Custom Production • DNA/RNA • Proteins/Peptides • Supplier

43 BIOPRO Baden-Württemberg

BioChem GmbH BioChem GmbH Daimlerstr. 5 b – your analytical contract laboratory D-76185 Karlsruhe In 1973 BioChem was founded by Dr. Walter Phone: +49 (0) 721/97 37 0 Massmann († 1998), a medical specialist in Telefax: +49 (0) 721/97 37 222 pharmacology and microbiology who was a well [email protected] acknowledged occupational medicine expert. www.biochem.de The origin of BioChem‘s laboratory activities star- worthy partner for analytical quality control inclu- Contact person: ted with the analysis of biological and microbio- ding stability control and developmental activities. Dr. Jürgen Branke logical parameters. Stepwise our analytical service Technical Managing Director portfolio was extended by adding a variety of At BioChem you will find within our 3 core chemical and molecular biological testing proce- competencies of Branches: dures during the 80‘s and 90‘s. In 1981 BioChem • microbiological • Pharmaceutical industry was registered as a limited company. • physico-chemical • Chemical industry • molecular biological • Medical device industry testing a widespread variety of different tech- • Cosmetic industry nologies established.

Employees: >60 Sterility, bacterial endotoxin, microbial contamination testing are beside chromatographic, Production range/Services: elemental or PCR analysis only some keywords Analytical testing of giving an idea of our analytical portfolio. • Microbiological Due to continuous growth a new facility was • Physico-chemical set up and BioChem moved successfully into Please visit www.biochem.de to see our • Molecular biological samples a state-of-the-art laboratory in 1988 which was complete areas of expertise. partly modernized and renewed in 2005. Fields of action: BioChem established already in its early years the • Analytics Nowadays, under the direction of BioChem‘s highest quality standard following current GMP- / • Biotechnological Services principal shareholder Dr. Ludwig Massmann, GLP-regulations according different international we are part of several internationally establis- requirements. BioChem is GMP-/GLP-certified as hed business units which are consolidated well as FDA-inspected and registered. within the BioChem Holding GmbH.

The expertise of more than 60 in-house experts as microbiologists, chemists, molecular biologists, biotechnologists combined with a comprehensive network of high professionals allows us to serve all of your needs as a competent, reliable and trust-

44 biomers.net GmbH Söflinger Str. 100 D-89077 Ulm Phone: +49 (0) 731/7 03 96 0 Telefax: +49 (0) 731/7 03 96 11 [email protected] biomers.net is your service partner for all aspects delivery of your custom-synthesized products www.biomers.net of oligonucleotides. We offer you a broad product via express mail service. As a fully indepen- range from DNA primers over single- und multi- dent company being managed by its owners Contact person: modified complex oligonucleotides to RNA syn- we can give you a maximum on flexibility Dr. Matthias Resmini thesis in various scales. Our interdisciplinary team and efficiency due to lean hierarchies and with well proven expertise on the fields of nucle- fast decision making processes. Employees: 30 ic acid chemis try and oligonucleotide production enables us to cater to your most special require- Production range/Services: ments. Our experienced staff will be pleased to • Biopolymer synthesis assist you at all times with your questions around • Oligonucleotide custom selection and use of oligonucleotides. synthesis

A highly automated production and quality Fields of action: control lab and state-of-the-art computer • Biotechnological Services and database systems assure you fast order • Custom Production processing between electronic ordering • DNA/RNA through our online ordering system to the

Oligonucleotides biomers.net

45 BIOPRO Baden-Württemberg

BIOMEVA GmbH BIOMEVA GmbH, a reliable and experienced Czernyring 22 provider of contract services in the biopharmaceu- D-69115 Heidelberg tical industry, is dedicated to meeting the manu- Phone: +49 (0) 6221/90 26 0 facturing needs for the production of microbially Telefax: +49 (0) 6221/90 26 90 expressed protein products. Our current Good [email protected] Manufacturing Practices (cGMP) production www.biomeva.com facility and extensive technical expertise provide the support to obtain regulatory approval. Since Contact person: 1993 BIOMEVA has been producing more than Dr. Thomas Pultar, CEO 350 batches of cGMP- compliant material for over Production and purification systems include 30 customers worldwide. Partners benefit from the following: Employees: 40 BIOMEVA’s track-proven operational expertise in • Fermenters with working volumes of 10 L, the transfer, development, optimization, scale-up 100 L, and 1,000 L Production range/Services: and validation of cGMP processes. • Continuous centrifugation • Contract manufacturing of biophar- • High-pressure homogenizer maceuticals according to cGMP Large-scale production of Active • Protein micro-filtration and ultra-filtration • Microbial fermentation Pharmaceutical Ingredients • Sterile filtration • Strain development Our Heidelberg (Germany), facility is speci- • Column chromatography • Process development and alized in the manufacture of active pharmaceu- • Bulk product filling optimization tical ingredients expressed in microbial systems. • Cell banking Recombinant material on a clinical and com- Microbial Cell Banking • Development and validation mercial scale can be produced in batches of up Master and working cell banks are manufac tured, of analytical methods to 1,000 L. This facility houses laboratories for characterized and tested in state-of-the-art labora- • Process validation E. coli cell bank production, characterization tories according to FDA and ICH requirements. and storage, classified suites for fermentation, Fields of action: chromatography, bulk filling and QC laborato- Quality Control • Biotechnological Services ries. A Class 100/1,000 filling suite is maintained To support cGMP production activities, the qua- • Contract Research for bulk product filling. lity control (QC) group ensures that all facilities, • Custom Production equipment and critical materials are under con- • Production Organisms trol and cGMP-compliant. • Proteins/Peptides • Therapeutics Quality Assurance The mission of quality assurance (QA) is to ensure that all manufacturing at BIOMEVA fulfills cGMP requirements, and that we exceed clients’ quality expectations. Our QA auditors provide inspection, auditing and monitoring of all production activities.

46 With more than 27 years experience BIOPHARM BIOPHARM GmbH is a well-known innovator in the field of Regene- Czernyring 22 rative Medicine. With our proprietary Growth D-69115 Heidelberg Factor Platform Technology we can offer tailor Phone: +49 (0) 6221/53 83 0 made drug design for innovative products in the Telefax: +49 (0) 6221/53 83 20 field of bone, cartilage and wound regeneration. [email protected] With two major license deals in place (Phase I/II www.biopharm.de and Phase II) BIOPHARM has proven its unique www.pw-technologies.com market position and strong innovation pipeline. in partners who share our passion for innovation in Regenerative and Personalized Medicine and Contact person: BIOPHARM‘s business case covers drug dis- are interested to work with us to fully exploit the Dr. Frank Plöger covery and early stage development and all potential of our unique and proprietary Growth Fac- stages of pre-clinical development. We strive tor Platform Technology and associated expertise. Employees: 30 to out-license our projects to partners after pre-clinical proof-of-concept for further clinical We have a proven track record of moving pro- Production range/Services: development and commercialization. jects from early-stage research through to pre- • Regenerative Medicine clinical development. Our capabilities include • Woundhealing BIOPHARM‘s current projects include the world-class science, as well as an experienced • Orthopedics development of a bioactive scaffold for wound staff and state-of-the-art laboratory facilities in • Technology Scouting healing in cooperation with the Freudenberg the No.1 Biotech area in Germany. We invite Group (Germany), a bioactive bone cement potential partners to explore the unique opportu- Fields of action: incorporating the latest innovation of our growth nities of our current projects of the BIOPHARM • Biotechnological Services factor platform technology (in cooperation with product pipeline for further clinical development. • Contract Research University of Jena and funded by the Germany • Diagnostics Ministry of Education and Research) and the We seek strategic cooperations with academic • Proteins/Peptides development of a novel biomarker for liver fibro- institutions and companies in the Biotech, • Therapeutics sis (performed by PW Technologies GmbH, a Pharma and Med-Tech industry to constantly • Tissue Engineering sister company of BIOPHARM GmbH). supply our technology and product pipeline and to have access to complementary technology and INVESTMENT & PARTNERING development capabilities. Establishing partnerships and alliances is a key business strategy of BIOPHARM. We are interested TECHNOLOGY SCOUTING BIOPHARM understands what it takes to successfully identify potential technologies and product concepts. We have the expertise and capabilities to assess and examine whether early- stage developments bear a product potential addressing key markets.

47 BIOPRO Baden-Württemberg

BioRépair GmbH Blumenstr. 4 D-74889 Sinsheim Phone: +49 (0) 7261/97 17 60 Telefax: +49 (0) 7261/97 17 61 [email protected] www.biorepair.com

Contact person: Martin F. Trinkner

Branches: Blumenstr. 4 74889 Sinsheim, Germany Sterneckstr. 55 5020 Salzburg, Austria BioRépair® was founded in 1997 in the innovative BioRépair® offers diagnostics for human and BioRegio Rhein Neckar close to Heidelberg. veterinary labs. Employees: 5 In cooperation with universities and private institutes we develope and produce diagnostics Our main products are: Production range/Services: for immunological, mikrobiological and parasito- • Point of care testing • Parasitology logical detections. Our own research and deve- • Rapid tests • Microbiology lopment department guarantees for the output • Diagnostics for parasitology and microbiology • Point of care testing of new techniques and innovative diagnostics. • Western blots for parasitology • Products for veterinary diagnostics Fields of action: Our parasite concentration system (see picture) • Research products (Acute phase proteins) • Diagnostics is one of the leading products in Europe to • Supplier detect parasites, larvae and their eggs out of BioRépair is ISO 9001 certified – All our pro- stool samples from humans and animals. ducts are CE-marked

48 Product innovations in oncology and biosyn Arzneimittel GmbH intensive care medicine Schorndorfer Str. 32 biosyn Arzneimittel GmbH is a private owned D-70734 Fellbach pharmaceutical company located in Fellbach near Phone: +49 (0) 711/5 75 32 00 Stuttgart in the Federal Republic of Germany, Telefax: +49 (0) 711/5 75 32 99 founded in 1984. The company now has approx. [email protected] 80 employees in Germany and in its subsidiaries www.biosyn.de in Switzerland, Austria and the USA. Contact person: biosyn Arzneimittel GmbH has specialised pri- Dr. rer. nat. Thomas Stiefel marily in the fields of intensive care medicine and oncology. biosyn currently offers around 30 Branches: drugs approved in 22 countries worldwide. Wien (Austria) Balzers, Liechtenstein (Switzerland) biosyn markets world-wide pharmaceutical pro- Carlsbad, California (USA) ducts and active pharmaceutical ingredients in the fields of trace elements, minerals, biologics As a research oriented pharmaceutical company bio- Employees: approx. 80 and biotechnology, respectively. syn focuses on the development of innovative biotech products. About 25 per cent of the annual turnover Production range/Services: biosyn Arzneimittel GmbH represents a classi- are invested in research for highly effective drugs Hemocyanin (KLH), cal pharmaceutical company with all necessary based on new discoveries in molecular biology. IMMUCOTHEL®, VACMUNE®, functions: manufacturing, regulatory affairs, mar- cytostatics, hormone antagonists, keting, distribution, finances. Furthermore the keyhole limpet hemocyanin (KLH) for the treat- selenium compounds company operations are especially focused on ment of bladder cancer or as carriers for no vel R & D in product and clinical development. vaccines (IMMUCOTHEL®, VACMUNE ®). Fields of action: biosyn‘s laboratories in Fellbach are GMP-cer- • Agriculture/Food The manufacturing of biosyn‘s proprietary active tified. biosyn Vertriebs AG in Balzers, Liech ten - • Analytics pharmaceutical ingredients is established in their stein and the biosyn Corporation in Carlsbad, • Diagnostics own production facilities in Fellbach: Sodium California, USA, are subsidiaries of biosyn. biosyn • Proteins/Peptides selenite for injectable selenium (Selenase®) or also has a scientific office in Austria. • Therapeutics

Sea snail Megathura crenulata (keyhole limpet)

49 BIOPRO Baden-Württemberg

BioTeSys GmbH Founded in 1999 as a spin-off of the University of Schelztorstr. 54-56 Hohenheim, BioTeSys GmbH is nowadays a highly D-73728 Esslingen productive company certified according to ISO Phone: +49 (0) 711/31 05 71 50 9001:2008 in the sectors analytical chemistry, cell- Telefax: +49 (0) 711/31 05 71 51 based test systems and clinical studies. Additionally, [email protected] the sector analytical chemistry has been accredited www.biotesys.de according DIN IEC 17025:2005 since 2003.

Contact person: The range of services includes screening methods solicitor, if legal issues regarding product descrip- Dr. Jürgen Bernhardt for measuring the bioactive potential of substan ces tions or marketing need to be taken into consi- or substance mixtures by means of HPLC or pho- deration. Whenever external partners are called Employees: 17 tometry (accredited according to DIN / EN ISO upon, our team will plan and organise all necessary IEC 17025:2005), in vitro test procedures using services as well as prepare scientific reports based Production range/Services: single cell cultures, cocultures and organotypic cul - on the data obtained. If expert opinions should be • Cell based test systems ture models as well as planning, coordination and required, BioTeSys can arrange these through its (Uptake, Bioavailability, Effects, conduct of clinical studies in the area food, dietary well-established links to universities. This highly Cytotoxicity, automated cell cul- supplements, dietary foods for special medical pur - competitive efficient concept allows us to offer our ture processes) poses, cosmetics and consumer health care / OTC. customers a highly flexible and time-optimised ser- • Intervention studies for scientific vice of high quality at favourable terms. substantiation of products focused BioTeSys provides a service concept with a modu- on nutrition (NEM, EBD, func- lar structure. The interdisciplinary team of expe- As reliable service provider BioTeSys stands for tional food) and cosmetics rienced and motivated staff members form the quality. The advantages of an external service • Analytics focused on HPLC and core. A number of selected and reliable coopera- provider are obvious: You save time, since we are Photomety (various biological tion partners complete this team. This allows that working with state-of-the-art technology and the samples/ botanicals) extensive and complex task assignments, such as latest know-how at BioTeSys. You save money, as • In vivo / in vitro scientific substanti- multifaceted analytical requests (coupled-mass you no longer need to continuously modernise ation of ingredient/product effects GC/LC-, MS-ICP-, NMR-, mIR-methods, etc.), costly in-house analysis technology and finally, • In vitro Toxicity testing can be reliably processed. By involving medical most importantly, your business and its staff can specialists, specialised clinics or a certain group of fully focus on their actual core competences. A Fields of action: test subjects, BioTeSys can offer a wide range of team of young, highly-motivated staff members • Agriculture/Food options in the field of clinical studies. BioTeSys can will continue to ensure that properties are turned • Analytics also provide assistance by consulting a specialist into advantageous features. • Biotechnological Services

50 BioTissue Technologies GmbH BioTissue Technologies GmbH Engesserstr. 4b BioTissue Technologies is an innovative bio- D-79108 Freiburg im Breisgau technology company manufacturing and distri- Phone: +49 (0) 761/7 67 65 80 buting biological tissue replacement products Telefax: +49 (0) 761/7 67 64 30 in the medical market. Since 1997 BioTissue [email protected] Technologies has been specializing in the www.biotissue.de manufacture of autologous cell-based tissues as well as in advanced cell-free implants for Contact person: tissue regeneration. At the moment BioTissue Dr. Eszter Tanczos Technologies is active in two specialist areas: orthopaedics/trauma surgery and dental/maxil- Branches: lofacial surgery. BioTissue AG Zürich / TransTissueTechnologies Berlin Products BioSeed®-C is an autologous three-dimensi- in the periosteum. The graft consists of a Employees: 19 onal chondrocytes graft which is grown from complex three-dimensional cell system based the patient’s own cartilage cells. Indications on the patient’s vital cells. For over 10 years, Production range/Services: are traumatically conditioned articular carti- BioSeed®-Oral Bone has been used in jaw BioSeed®-C: autologous three- lage defects and early stages of arthritis. The bone augmentation, such as sinus lift opera- dimensional chondrocyte graft patented, stable and three-dimensional matrix tions, but also in lateral onlay grafts and BioSeed®-Oral Bone: autologous can also be used in arthroscopic surgery. Up to periodontology. three-dimensional jaw bone draft now more than 3000 patients have been trea- chondrotissue®: cell free cartilage ted successfully. The 3D-grafts are produced according to implant European legislation in a GMP laboratory, chondrotissue® is an advanced scaffold for specially developed for cell cultivation and Fields of action: intra-articular application in order to regene- managed under strict criteria. • Cells/Cell Lines rate traumatic or degenerative cartilage defects. • Therapeutics This product is a cell-free, off-the-shelf imp- Research • Tissue Engineering lant that is to be used in combination with BioTissue Technologies works together with microfracturing, since it uses the chondrogenic leading scientific centres in the field of ortho- potential of stem cells from the subchondral biology, in particular with the 100% subsidiary bone. Thanks to a combined technology the TransTissue Technologies GmbH in Berlin, scaffold is stable and flexible at the same time, which is in close relation with various research allowing an arthroscopic and secure fixation. departments of the Charité University Hospital, the Freiburg University Teaching Hospital, the BioSeed®-Oral Bone is a bone graft culti- University Hospitals in Heidelberg and Münster vated from the patient’s own cambium cells as well as with the ETH Zürich.

51 BIOPRO Baden-Württemberg

BMG LABTECH GmbH Allmendgrün 8 D-77799 Ortenberg Phone: +49 (0) 781/96 96 80 Telefax: +49 (0) 781/96 96 86 7 [email protected] www.bmglabtech.com

Contact person: Frau Sabine Schillinger BMG LABTECH GmbH engineers and produ- The latest masterpiece of the German engineers is Branches: ces highly sensitive microplate readers. In the the unique monochromator system with adjustable USA, UK, France, Japan, Australia year 2011 BMG LABTECH moved from their bandwidths. This technology is integrated in the location in Offenburg to their new building in multimode microplate reader named CLARIOstar. Production range/Services: Ortenberg in the Black Forest. • Microplate readers • Protein-Protein-Interaction The portfolio of BMG LABTECH includes mul- • Microbial Growth timode microplate readers like the FLUOstar, • Food Chemistry which measures all non-radioactive methods like • Antioxidants fluorescence, luminescence, absorbance; readers • Migration dedicated for absorbance measurements only as • GPCRs well as the high-end reader for high throughput • Membranes screening like the PHERAstar FS. • Aggregation/Adhesion • SNP Genotyping

Fields of action: • Analytics • DNA/RNA • Proteins/Peptides

52 Boehringer Ingelheim

Biopharmaceuticals GmbH Binger Str. 173 D-55216 Ingelheim Phone: +49 (0) 6132/77 0 Telefax: +40 (0) 6132/77 98 28 7 bioxcellence@boehringer- ingelheim.com www.bioxcellence.com

Boehringer Ingelheim As a leading biopharmaceutical contract manu- Contact person: Biopharmaceuticals GmbH facturer with more than 35 years of experience – Dr. Julia Knebel we have brought more than 20 molecules to the The Boehringer Ingelheim group is one of biopharmaceuticals market. All types of services Branches: 3 biopharmaceutical the world’s 20 leading pharmaceutical compa- from mammalian cell line or microbial strain manufacturing facilities: nies. Headquartered in Ingelheim, Germany, development to final drug production can be Germany, Austria, USA it operates globally with 145 affiliates and more delivered within a one-stop-shop concept. Biopharma Development and Manu- than 46,000 employees. Since it was founded facturing Site Germany: Biberach in 1885, the family-owned company has been Boehringer Ingelheim delivers services for pre- an der Riss, Baden Württemberg committed to researching, developing, manuf- clinical development up to global market sup- acturing and marketing novel medications of ply with a strong commitment to its customers Employees: 46,000 high therapeutic value for human and veteri- at its manufacturing facilities for mammalian nary medicine. cell culture and microbial fermentation. Production range/Services: Own Biopharmaceuticals: Boehringer Ingelheim Biopharma Contract Boehringer Ingelheim has many years of expe- Actilyse® / Metalyse® / Manufacturing is now represented by its new rience in multiple molecule classes such as Imukin® / Beromun® brand Boehringer Ingelheim BioXcellence™. monoclonal antibodies, recombinant proteins, interferons, enzymes, fusion molecules and Fields of action: plasmid DNA. Furthermore, high-titer platform • Biotechnological Services technologies for new antibody mimetic formats • Cells/Cell Lines such as scaffold proteins and antibody fragments • Custom Production are available for the manufacture of customer. • DNA/RNA • Production Organisms Boehringer Ingelheim can secure product sup- • Proteins/Peptides ply globally and throughout the entire product • Therapeutics lifecycle–transferring customer projects at any stage, delivering to almost any scale, to any market and thereby makes outsourcing easy.

53 BIOPRO Baden-Württemberg

CANDOR Bioscience GmbH Simoniusstr. 39 D-88239 Wangen im Allgäu Phone: +49 (0) 7522/7 95 27 0 Telefax: +49 (0) 7522/7 95 27 29 [email protected] www.candor-bioscience.com

Contact person: Dr. Peter Rauch, Dr. Tobias Polifke CANDOR Bioscience GmbH CANDOR quality comprises highest product Employees: 7 The ELISA Experts quality, highest quality standards and demanding quality control in production in addition to Production range/Services: CANDOR Bioscience GmbH is an internatio- comprehensive product support and customer • Antibody stabilizers nally oriented, innovative, profitable and priva- service. • Conjugate and coating stabilizers tely owned enterprise. for ELISA kit production The company is certified according to DIN EN • Optimizers for immunoassays CANDOR develops, produces and distributes a ISO 9001:2008. • Solutions for immunoassays comprehensive selection of premium solutions • customized buffer production for immunoassays. from 1 liter to 2000 liters batch volumes CANDOR offers more than 50 different pro- • ELISA development, optimiza- ducts including optimizers, blockers, stabilizers tion and validation and buffer solutions for immunoassays. By using these solutions the reliability of results can be Fields of action: improved, the assay can be simplified and pro- • Analytics cess times can be reduced. • Biotechnological Services • Custom Production • Diagnostics • Supplier • Proteins/Peptides

54 content. This gives our clients an opportunity to cecolabs UG analyze putative alterations in the composition of Waldhäuser Str. 70/8 these bacterial cell walls within a short time. Our D-72076 Tübingen scientists additionally support our clients in inter- Phone: +49 (0) 7071/29 77 61 9 preting the obtained results. These analysis, using Telefax: +49 (0) 7071/29 50 65 LC/MS, UPLC and ÄKTA systems, are of great [email protected] importance for, amongst other things, the deco- www.cecolabs.de ding of alterations in the cell walls of antibiotic resistant bacteria. In addition, our cell wall com- Contact person: ponents can be utilized in immunological studies Daniel Kühner cecolabs UG was founded in late 2011 by Daniel (inflammation, allergies) or as adjuvants in vaccine Doþan Doruk Demircioþlu Kühner, Doþan Doruk Demircioþlu and Prof. development. Dr. Friedrich Götz, as a spin-off company of the Employees: 6 chair of microbial genetics at the Interfaculty Our standard portfolio includes whole cell wall Institute of Microbiology and Infection Medicine extracts (so called crude extracts, which consist Production range/Services: Tübingen (IMIT). of the whole macromolecule PGN), PGN frag- • Peptidoglycan analysis ments in different package sizes and cell wall • Peptidoglycan isolation We are primarily specialized in the isolation enzymes, e.g. lysostaphin. Our ultrapure cell wall • Enzymes and purification of ultrapure bacterial cell walls components, as well as our services, are available • Isolation of microbial compounds (murein or peptidoglycan (PGN)) from all types to scientists all around the world. • Adjuvants of bacteria (gram-negatives and positives) and its fragments (e.g. monomers – hexamers up to Secondarily, we also offer other chemical com- polymers) via our newly developed technique pounds, e.g. Pam3Cys, Pam2Cys and others, which Fields of action: called Peptidoglycan-Next Generation Isolation are utilized in various fields of research (e.g. toll-like • Analytics (PGN-NGI). This technology also enables us to receptor research), as adjuvants and many more. • Biotechnological Services offer fast and accurate peptidoglycan analysis ser- • Custom Production vices, which also include the analysis of its amino We continuously extent our product portfolio. • Production Organisms acid composition or its wall teichoic acid (WTA) Please visit us on www.cecolabs.de

55 BIOPRO Baden-Württemberg

CeGaT GmbH CeGaT, Center for Genomics and Transcriptomics, Paul-Ehrlich-Str. 17 is a sequencing and diagnostics company. All rela - D-72076 Tübingen ted services are performed in-house. We offer: Phone: +49 (0) 7071/5 65 44 00 Telefax: +49 (0) 7071/5 65 44 22 1. Next-Generation-Sequencing: [email protected] CeGaT is applying the HiSeq 2500 (Illumina) www.cegat.de and SOLiD 5500xl (Life Technologies) Platforms for Next-Generation-Sequencing. Next- Contact person: Generation-Sequencing enables rapid and cost disease by NGS. The obtained data are analysed Dr. med. Dr. rer. nat. Saskia Biskup efficient sequencing of up to 600 Giga-bases and all variants being found are validated on per run. CeGaT sequences DNA and RNA of the capillary sequencer. Using Diagnostic Panels Employees: 45 humans, animals, plants and microorganisms. is significantly faster and less expensive than Depending on the particular project, Exomes, sequencing the single genes of a certain disease. Production range/Services: Transcriptomes, Epigenomes, microRNA or It also increases the probability to detect the • Molecular Genetics Diagnostics: complete Genomes are deciphered. In addition genetic cause of the illness. Sequencing of single genes, to pure sequencing, extensive bioinformatic ana- CeGaT is currently offering more than 97 interpretation of data and lysis of the generated data is offered. Diagnostic Panels covering over 1,000 medical report Genes for the following diseases: • Next-Generation-Sequencing 2. Molecular Diagnostics: • Brain Development Disorders (NGS): Sequencing of genomes, CeGaT offers genetic testing for all known dis- • Cardiac Diseases exomes, transcriptomes, etc. on ea se-causing variants in the human genome. This • Ciliopathies SOLiD 4 and SOLiD 5500xl, testing comprises Sanger-Sequencing, analysis • Connective Tissue Disease bioinformatic analysis of data of the data and issuing of a medical report. Two • Epilepsies & Migraine • Diagnostic Panels: Parallel 96-Capillary Sequencers are used for sequencing. • Eye Diseases sequencing of all genes related • Hearing Loss with a certain disease by NGS 3. Diagnostic Panels: • Ion Channel Diseases and medical report CeGaT has developed Diagnostic Panels in • Metabolic Diseases • Customized FISH assays collaboration with its clinical partners. These • Mitochodriopathies Diagnostic Panels enable a massive parallel • Neurodegenerative Diseases Fields of action: sequencing of all genes associated with a certain • Neuromuscular Diseases • Analytics • Rasopathies • Bioinformatics • Tumor Syndromes • Biotechnological Services • Diagnostics 4. Customized FISH-Assays: • DNA/RNA CeGaT offers the development of FISH (fluorescence in-situ hybridisation) assays for in-situ detec - tion of amplifications, deletions, and translocations for nearly all gene loci, tailored to individual needs.

56 Cellca: partner of the pharmaceutical industry Cellca GmbH Cellca is a recognized leader in custom develop- Uhlmannstr. 28 ments for biologics production for the pharma- D-88471 Laupheim ceutical industry. Cellca is specialized on upstream Phone: +49 (0) 7392/9 66 48 10 processing in particular the protein production in Telefax: +49 (0) 7392/9 66 48 29 mammalian cell lines. Cellca works for customers [email protected] worldwide for business or research purposes. www.cellca.de

Competitive technology platform with large liters scale in order to ensure process transfer Contact person: valuable benefits and scale-up to the production scale. Hugo de Wit Based on its in-depth expertise, know-how and intellectual property, Cellca has established a Proven track record Employees: 20 unique technology platform, which is one of the Cellca has a proven track record of successful most competitive systems available. It is cha- projects highlighting the promised strength Production range/Services: racterized by high efficiency regarding quality, and benefits: Custom developments for the quantity and short development time, robust- • More than 30 projects have been completed, production of biopharmaceutical ness and direct process scalability. So, customers > 95% deliver 3 g/L or more. proteins from mammalian (CHO) and partners benefit from reduced cost of goods, • Within six months Cellca can deliver a re - cell cultures: reduced risks and a faster time-to-clinic / market. search cell bank starting from DNA together • Cell line & process development with a direct scalable process that produces • Optimization of existing Products and services: delivering productivity > 3 g/L within 12 to 14 days cell fed batch culture. processes and media Cellca offers the following products and ser- • Cellca can improve the yield of an existing • For all types of antibodies and vices for the production of biopharmaceuticals process by a factor of 2 to 3 in 3 - 5 months. fusion proteins. from mammalian (CHO) cell cultures: • Cellca’s technology platform eliminates the • Cell line & process development need for expensive scale-up studies. Fields of action: • Optimization of existing processes and media. • In all projects comprising all types of antibo- • Biotechnological Services • For all types of antibodies and fusion proteins. dies and fusion proteins, targets had been • Cells/Cell Lines (over)achieved. • Contract Research The cell line development leads to processes pro- • Custom Production viding high protein concentration and high pro- Cellca: worldwide partnering for success • Production Organisms tein quality. All process parameters are defined at Cellca is in close cooperation with partners world- • Proteins/Peptides wide: small and large pharma companies, universi- • Therapeutics ties and research institutions. Important industrial partners are GE Healthcare Bio-Sciences Corp., Pro- tagen AG, and Rentschler Biotechnologie GmbH.

Whatever you are looking for, Cellca understands your needs and finds the right solution.

57 BIOPRO Baden-Württemberg

Cellendes GmbH Markwiesenstr. 55 D-72770 Reutlingen Phone: +49 (0) 7121/1 59 40 0 Telefax: +49 (0) 7121/1 59 40 99 [email protected] www.cellendes.com

Contact person: Dr. Brigitte Angres Cellendes is a life science company offering a with bioactive factors, 3-D Life hydrogels achieve comprehensive technology for the controlled high performance to suit many applications. Employees: 4 design of cell environments in 3-D cell culture. This technology serves the increasing demand Main Features of 3-D Life Hydrogels: Production range/Services: for cell-based assays with a closer ressemblance • Defined composition of biologically inert • Biomimetic hydrogels for to the environment in the living organism. Areas synthetic polymers and biopolymers 3-D cell culture of application include basic research, drug devel- • User-controlled biomimetic modifications • Custom production of opment and biomedical engineering. (e.g. peptides, proteins) hydrogel reagents • Wide range of ligand density (up to 5 mmol/l) • 3-D cell-based assay The 3-D Life Technology: Cell Environment • Tunable gel strength development Design at Your Fingertips! • Choice of non-degradable, user- degradable and cell-degradable gels or combinations thereof Fields of action: Cellendes‘ 3-D Life products are a toolbox of • Amenable to automation for multi-well • Cells/Cell Lines reagents which provides high flexibility to the plate dispensing • Supplier user in composing hydrogels with biomimetic • Injectable cell delivery and in situ gel • Tissue Engineering modifications as desired for each specific cell formation culture. Due to the inert nature of the basic material and its high capacity for modification Applications: • 3-D cell cultivation in basic research • 3-D cell-based assays and tissue models for drug screening • Development of 3-D biomaterial for regenerative medicine and medical engineering

Cellendes seeks collaborations with academic and industrial partners to explore the use of the 3-D Life technology in complex cell-based assays and tissue models for drug screening as well as in biomedical engineering.

58 CellGenix GmbH is a biotech company active CellGenix GmbH in the field of cellular therapies and regenerative Am Flughafen 16 medicine. CellGenix was founded in 1994 and is D-79108 Freiburg located in Freiburg, Germany, where it operates a Phone: +49 (0) 761/8 88 89 0 state-of-the-art GMP manufacturing facility. The Telefax: +49 (0) 761/8 88 89 80 0 company develops, manufactures and markets [email protected] high-quality reagents for ex vivo cell culture. As www.cellgenix.com a first company to obtain a GMP manufacturing authorization for cell processing in Europe, Contact person: CellGenix can build on more than 15 years of in- CellGenix is continuously expanding its portfo- Prof. Dr. med. Felicia Rosenthal house experience in clinical cell therapies. lio of serum-free media and reagents for ex vivo cell processing: Employees: 50 High-quality Cell Culture Reagents • Serum-free media for the cultivation of den- CellGenix has taken the lead in providing custo- dritic cells, hematopoietic stem cells, T-cells, Production range/Services: mers with high-quality GMP reagents that are NK-cells and mesenchymal stem cells and • Cell Culture Reagents and Tools suitable, safe and reliable to be used as ancillary chondrocytes • Cell Therapy and Regenerative materials in clinical ex vivo cell culture. For many • Preclinical-grade and GMP-grade cytokines Medicine years, CellGenix has developed and manufactured for optimal growth support of differentiation products according to GMP guidelines and under of hematopoietic stem and progenitor cells, Fields of action: ADCF (Animal derived component-free) condi- as well as dendritic cells, T-cells, NK-cells, • Cells/Cell Lines tions. We have filed DMF (Drug Master File) for MSC, ESC and iPS cells • Supplier many of our products at the FDA and other major • Teflon bag systems with unique properties • Therapeutics regulatory authorities. Conformance with the for cell culture and cryopreservation • Tissue Engineering new USP (United States Pharmacopeia) General Chapter <1043> “ancillary materials for cell, gene, Quality Management System and tissue-engineered products” and USP <92> To further demonstrate our commitment to “growth factors and cytokines used in cell therapy continual improvement of quality and service manufacturing” supports our high quality claims. we have entered into the certification process for DIN ISO 9001:2008, a globally recognized Our products are used by leading experts and quality management system standard. The certi- proven in clinical trials throughout the world. fication was monitored by the TÜV and covers development, production, storage and distribution of ex vivo cell culture reagents. Hereby, CellGenix extends existing standards of quality in GMP manufacturing to embrace company- wide processes. On the basis of our quality standards as a reliable partner, we optimize quality, service and our daily delivery performance.

59 BIOPRO Baden-Württemberg

Cellzome GmbH Cellzome is a leader in Chemoproteomics, a Meyerhofstr. 1 technology which monitors the interaction of D-69117 Heidelberg small molecules with their protein targets under Phone: +49 (0) 6221/13 75 70 close-to-physiological conditions, directly in Telefax: +49 (0) 6221/13 75 72 01 cells or tissues. www.gsk.com Cellzome was founded 2000 as a spin-off of the Contact person: European Molecular Biology Laboratories (EMBL) Dr. Gitte Neubauer and is located on the EMBL campus in Heidel- berg, Germany. About 55 scientists and technical Employees: approx. 60 staff working at Cellzome represent 10 different nationalities and cover a variety of skill sets, ran- small molecules on the proteome, the protein Fields of action: ging from physics, mass spectrometry and bioinfor- content of a cell or tissue, which comprises in • Analytics matics to cell biology, compound screening, and excess of 10,000 different proteins. We apply • Proteins/Peptides medicinal chemistry. As an independent company, chemoproteomics in a quantitative manner at • Therapeutics Cellzome entered two drug discovery collabora- various stages in drug discovery and develop- tions with the GlaxoSmithKline (GSK) Immuno- ment, from screening to selectivity profiling Inflammation therapy area, the first, initiated Sep- of drugs in different cell and tissue types. tember 2008, focused on kinases and the second, A complementary platform is used to map initiated 2010, on epigenetic targets. The company disease-relevant signalling pathways. This is was acquired by GSK in May 2012 and was inte- achieved by the quantitative characterization of grated as fully owned GSK daughter company in multi-protein complexes or mapping of post- GSK’s Platform Technology and Sciences team. translational modifications, and the effect of drug candidates on these systems when applied Cellzome’s technology in vitro or in vivo. Cellzome has published 10 Cellzome has pioneered the advancement of landmark articles in the Nature journals which chemoproteomics to study the effects of active describe these approaches.

60 CETICS Healthcare

Technologies GmbH Schelztorstr. 54-56 D-73728 Esslingen a. N. Phone: +49 (0) 711/30 06 55 0 Telefax: +49 (0) 711/30 06 55 29 CETICS provides groundbreaking analysis tech- [email protected] nologies in the fields of in-vitro toxicity assays www.cetics-ht.com and in-vitro diagnostics. Contact person: With proprietary technologies, CETICS ensures Dr. Martin Winter a drastic simplification of analyses in • diagnostics, Production range/Services: • personalized medicine, and • TOXXs Analyzer: automated • toxicology. FADU genotoxicity assay • SPECCs Analyzer: mid-infrared Cost-effective high-precision infrared spectra But CETICS also offers applications in toxicolo- spectroscopy metabolomics and can be obtained from biological samples such gy and personalized medicine. CETICS employs in-vitro diagnostics as blood serum, liquor, and cell culture super- the automated FADU assay, where DNA strand • Toxicology natants with the patented AquaSpec MIR spec- breaks and DNA repair can be demonstrated • Therapeutic Drug Monitoring troscopy method. Complex information about very rapidly and, for many samples, fully auto- • Pharmaceutical Development the individual composition of every sample matically. This information is of central signi- becomes available in digital form. ficance for the Chemical Risk Assessment for Fields of action: REACH as well as for cancer therapy. • Analytics CETICS provides the market with completely • Diagnostics new diagnostic possibilities and simultane- Automated FADU systems can be combined • DNA/RNA ously ensures significant cost reductions, also with AquaSpec modules, thus greatly enhancing • Supplier for the quantitative determination of routine the retrieval of information in toxicology and parameters. personalized medicine.

61 BIOPRO Baden-Württemberg

ChemCon GmbH Company Profile Engesserstr. 4b ChemCon GmbH is specialized in Contract Re - D-79108 Freiburg search and Custom Synthesis in the field of small Phone: +49 (0) 761/55 97 0 molecule organic and inorganic chemistry. Our Telefax: +49 (0) 761/55 97 44 9 strong point is the development of Synthetic Rou - [email protected] tes and Small Scale Manufacturing (mg to kg) of www.chemcon.com Fine Chemicals and Active Pharmaceutical Ingre- Contact person: dients (API’s) for preclinical use, all clinical phases Dr. Jürgen Hain and commercial mate rial. Our main strength is the transfer from Laboratory R&D to cGMP chemistry Branches: in our FDA audited clean room facility and the ChemCon America, Inc. work with cytotoxic material in injectible grade 187 East Crystal Lake Ave., quality under full microbiological control. Suite 1005 Lake Mary, FL 32746, USA ChemCon‘s services are covering the che- Phone: +1 (407) 323 1710 mical and pharmaceutical industrie‘s needs Telefax: +1 (407) 323 7078 from early stage development to routine

API & HPAPI production. Employees: 60

Production range/Services: • Elaboration of chemical processes and syn- • Commercial API manufacturing in small scale • R&D and chemical thetic routes (mg to kg up to 1t/year) under cGMP with development complete set of GMP documentation (TypeII • cGMP manufacturing of API • Implementation of synthetic routes from our Drug Master Files, Master Cleaning Records) in • Reference-substances customer and scale-up of chemical processes full compliance with all FDA and EU guidelines • Organic chemistry • Inorganic chemistry • Development and custom synthesis of organic • Stability and degradation studies • Bio-Inorganic products and inorganic chemical specialties and stand- • Neuroactive and cytotoxic ards (e.g. multi-step synthesis; chemistry of natu - • Handling of toxic and air/moisture sensitive substances ral products and protecting groups; stereoselec- compounds • Chemistry for R&D use tive synthesis; ligand synthesis; complexation) • Microbiological quality • Work at temperatures between -100 °C and assurance and analytics • cGMP-development for small molecules in 230 °C under pressure • CMC section support pharmaceutics, generics, diagnostics and research chemicals

Fields of action: • Analytics • Process transfer from R&D to cGMP with • Custom Production scale-up from mg to kg and process validation

62 Comprehensive Biomarker

Center GmbH Im Neuenheimer Feld 583 D-69120 Heidelberg Phone: +49 (0) 6221/91 433 10 Telefax: +49 (0) 6221/91 433 12 [email protected] www.cbioc.com Comprehensive Biomarker Center GmbH (CBC) Contract Research & Services: The Center of Excellence for Genomic Biomarkers Pre-Analytics Contact person: • DNA/RNA extraction from body fluid Kathrin Waurich-Hähnlein Providing complete solutions from experimental samples (Blood, Serum, Plasma, Urine, CSF, design to biomarker signatures CBC is your partner …) & FFPE tissues Employees: 15 for Clinical Research & Testing. With a focus on Biomarker Discovery microRNAs from body fluids CBC offers full sup- • Microarray (microRNA-, mRNA-, Production range/Services: port for successful biomarker discovery, screening epigenetic Profiling) • Preanalytics: DNA/RNA procedures, analyses, and validation. • Next Generation Sequencing (Small RNA, Extraction Services Transcriptome, Exome/Subgenome) • Biomarker Discovery on Fields of activity: Biomarker Validation Microarray & NGS CBC provides comprehensive biomarker ser- • High-Throughput qRT-PCR, Multiplex • Biomarker Validation on qRT-PCR vices and solutions enabling early diagnosis, Multibead Assay (Luminex, Firefly) & Multiplex Multibead Assay patient stratification, and monitoring of treat- Biostatistics • Bioinformatics and Biomarker ment responses. Non-invasive sample sources • Biomarker Signature Development, Signature Development & like whole blood, serum, plasma or urine are Multivariate Analysis Verification the key for early detection and therapeutic • Clinical Research monitoring. Therefore CBC has established Quality: Organizations (CROs) highly effective protocols for the extraction of CBC’s broad expertise in biomarker signature devel - • Pharma/Biotech (R&D, total RNA from various sample sources. opment results from diverse biomarker studies that Translational Research,…) involved more than 5,000 clinical samples. • Clinical Research CBC is operating SOP-based: • Standardized, experienced RNA extraction services Fields of action: • Standardized QC & robust quantification • Analytics • Bioinformatics for diluted samples • Biotechnological Services • Standardized Bioinformatics • Diagnostics => ISO 17025 Certification • DNA/RNA Take advantage of our expertise, optimized protocols, established technologies, and perform biomarker studies from clinical body fluid samples.

63 BIOPRO Baden-Württemberg

computomics® molecular data analysis

Computomics GmbH & Co. KG Computomics is a bioinformatics service provider Sand 14 for the analysis of next-generation sequencing data D-72076 Tübingen from plants and crops. Computomics offers a range Phone: +49 (0) 7071/56 83 99 5 of services starting with the assembly and leading [email protected] up to complex interpretations. Their clients are www.computomics.com scientists working in bioscience companies.

Contact person: Computomics was founded by the two managing Dr. Sebastian J. Schultheiss directors Dr. Sebastian J. Schultheiss and Dr. Tobias Dezulian in October 2012 together with Production range/Services: four professors from the Max Planck Institutes in • Genome Assembly/Annotation Tübingen and the University of Tübingen, who the location of the sense-conveying “sentences” • Transcriptome work in the fields of machine learning, bioinfor- and “words” within the genomic sequence, i.e., • Metagenomics matics and plant genomics. the genes and exons that contain the construction • Genomic Selector® blueprints for proteins. Bioinformatics analysts can • Epigenetics Computomics’ field of expertise is the analysis of also identify the sequence differences between genome sequencing data of crops such as cereals, individual plants as well as epigenetic markers Fields of action: fruits and vegetables for their clients in the agri- – short methyl residues attached to nucleotides – • Agriculture/Food cultural industry. These analyses help their clients which are induced by environmental signals and • DNA/RNA to grow high-yield plants, or strains with resistances regulate the activity of genes. • Bioinformatics to drought, parasites or high salt concentrations. Computomics is able to complete these analy- A sequencing project of a crop genome results ses in the shortest possible time thanks to their in several terabytes of data. Using algorithms at specific experience of working with plant data the height of scientific possibility, Computomics’ and their proprietary analysis workbench in bioinformatics analysts assemble an entire plant combination with their profound knowledge of genome from several million short fragments. It is bioinformatics methods. This inherent compe- quite a challenge to arrange the nucleotides in the titive edge entails that plant science companies correct order due to the many repetitions in plant from around the world regularly place orders with genomes. Afterwards, proprietary algorithms reveal Computomics for scientific studies of their plants.

64 Crinotec GmbH Crinotec GmbH – making analysis easier Sindelfinger Str. 3 D-72070 Tübingen Fields of Activity Phone: +49 (0) 7071/63 97 400 Crinotec GmbH specializes in design of new Telefax: +49 (0) 7071/63 97 401 analytical techniques for foodstuffs and beve- [email protected] rages. The company is located in Tübingen, in www.crinotec.de the south of Germany near Stuttgart. www.winealyzer.de

We provide custom designed analytical instru- ring process, it becomes possible to determine Contact person: ments based on bio- and chemosensors. Our important analytes both quickly and accurately. Dipl. Chem. Andreas Fiedler main focus is the development of new analy- The usual methods almost had a lot of disad- tical systems by combining new technologies vantages – interference with the matrix, long Employees: 4 with well tried sensor techniques for a wide analysis times and laborious techniques. This range of application. disadvantages can be avoided by Crinotec- Production range/Services: technologies. • Chemosensors The in-house electronic design and proto- • Biosensors typing in conjunction with custom software Wine represents a very complex matrix, there- • Food and beverage design guarantees an inter-coordinated work- fore it is necessary to develop sensors having a analysis systems flow. Modern equipment allows a reliable vali- negligible cross sensitivity. • Development of analytical dation of the developed analytical techniques. instruments Philosophy • Data acquisition systems Innovative Products Our ambition is to provide a great flexibility • Electronic design Proprietary developments in new sensor coa- concerning new products and technologies. • Software design tings and special designed analytical methods Therefore we attach great importance to a close Fields of action: represent the basis for our actual product. collaboration with universities and partners in • Agriculture/Food With this Multi-Parameter Analysis System, medium-sized enterprises. This guarantees a fast • Analytics designed for the use in the wine manufactu- and successful design for many individual needs. • Contract Research • Custom Production

65 BIOPRO Baden-Württemberg

Curetis AG About Curetis Max-Eyth-Str. 42 Founded in 2007, Curetis AG is a molecular dia- D-71088 Holzgerlingen gnostics company which focuses on the develop- Phone: +49 (0) 7031/4 91 95 10 ment and commercialization of reliable, fast and Telefax: +49 (0) 7031/4 91 95 19 cost-effective products for diagnosing severe infec- [email protected] tious diseases. The diagnostic solutions of Curetis www.curetis.com AG will enable rapid multiparameter pathogen and antibiotic resistance detection in only a few platform enables the DNA-based testing of all Contact person: hours, a process that today can take up to days or clinically relevant Oliver Schacht, PhD even weeks with other techniques. samples in a fully automated, unsupervised analy- Employees: approx. 50 To date, Curetis has raised total funds of over sis process requiring only few, quick manual pre- € 49.1 million (~ USD 64 million). The com- paration steps. The analysis thus can be performed Production range/Services: pany is based in Holzgerlingen near Stuttgart, with minimal operator time and without the need • Unyvero™ Solution (MDx Germany. Curetis has signed collaboration agree- of skilled staff or special infrastructure. Thereby, instrument platform) ments with Heraeus Medical, Sanofi Pasteur clinically relevant information is available within • Unyvero™ P50 Pneumonia and Cempra Inc. as well as several international about four hours to support an informed therapy Application distribution agreements. decision as early as possible. • Unyvero™ ITI (Implant & Tissue Infections) Application in deve- About the Unyvero™ System The first CE-marked Unyvero™ Cartridge, Unyvero lopment The CE-marked Unyvero™ System is a versatile ™ P50, focuses on pneumonia testing and simul - hardware platform for the detection of a broad taneously analyses 39 DNA targets. The se cond Fields of action: panel of bacteria and antibiotic resistances from a Unyvero™ application for implant & tissue infec- • Diagnostics single sample in one run. It processes a disposa- tions is already in product development. Car tridges • DNA/RNA ble cartridge providing the necessary reagents to for additional indications, such as blood stream complete the analysis from sample to result. The infections and tuberculosis, are in preparation.

66 CureVac is developing an entirely new class of CureVac GmbH therapies based on a fundamental new understand- Paul-Ehrlich-Str. 15 ing of the medical potential of mRNA. Using its D-72076 Tübingen RNA technology platform, CureVac is currently Phone: +49 (0) 7071/9 20 53 0 developing novel therapeutic mRNA vaccines Telefax: +49 (0) 7071/9 20 53 101 (RNActive®) for cancer and prophylactic vaccines [email protected] for infectious diseases and adjuvants based on www.curevac.com non-coding RNAs (RNAdjuvant®) for enhancing the immune response of other vaccines. CureVac’s approach is based on the discovery Contact person: that when modified and formulated, the direct Verena Lauterbach The company has successfully completed Phase application of mRNA via injection can lead to 1/2a studies with its RNActive® cancer vaccines the expression of functional proteins as well as Employees: 100 in prostate cancer and non-small cell lung cancer the generation of a broad and potent immune (NSCLC). Results so far have shown that mRNA- response (RNActive® Technology). Until now, Production range/Services: based products are safe and capable of inducing mRNA was regarded as being unsuitable for • RNActive® Immunotherapy in balanced immune responses including humoral therapeutic applications because of its instabili- prostate and non-small cell lung and cellular, Th1 and Th2 and effector and ty and difficult handling. cancer memory responses. In prostate cancer CureVac’s • RNActive® prophylactic vaccines RNActive® vaccine has been initiated Phase IIb The company was originated in the laboratories of • RNAdjuvant® study. In addition to developing its own pipeline, Professors Rammensee and Jung and spun off from • Immunotherapy CureVac is collaborating with Sanofi Pasteur and Tübingen University in December 2000 to develop • Prophylactic vaccines In-Cell-Art on a $33.1 million project co-funded and commercialize mRNA as a therapeutic. In by the Defense Advanced Research Projects 2012 CureVac completed an €80 million finan- Fields of action: Agency (DARPA) for the development of pro- cing round with its main investor, dievini Hopp • DNA/RNA phylactic vaccines in infectious diseases utilizing BioTech Holding. To date, the company has raised • Therapeutics its RNActive® technology platform. approximately €145 million in equity financing.

67 BIOPRO Baden-Württemberg

Cytonet GmbH & Co. KG Albert-Ludwig-Grimm-Str. 20 D-69469 Weinheim Phone: +49 (0) 6201/25 98 0 Telefax: +49 (0) 6201/25 98 28 [email protected] www.cytonet.de

Branches: Heidelberg (Germany) Durham (NC, USA) The Cytonet Group is an international bio- by Cytonet. The liver cells are isolated from technology company with sites in Weinheim, non-transplantable donated livers. Employees: 40 Heidelberg, Germany and Durham, NC, USA. Cytonet has 40 employees and develops and Cytonet was founded by a demerger from the Production range/Services: produces cell-therapeutic products which Roche Group in April 2000. The Dietmar Hopp • Liver cell therapy offer alternatives for existent therapies, e.g. family owns the majority of shares. Managing organ transplantations. In order to provide directors are Dr. Wolfgang Rüdinger and Dipl.- Fields of action: liver cell preparation for the treatment of Kfm. Michael J. Deissner. The SELICA study • Cells/Cell Lines urea cycle defects (UCDs), cells from dona- on liver cell therapy as a treatment for inborn • Therapeutics ted livers (obtained from organ procurement errors of liver metabolism in neonates and organizations in the US) are isolated and infants is currently ongoing in Germany, the processed in a complex procedure developed USA and Canada.

68 Data Analysis & Consulting GmbH da-cons GmbH

Get information from raw data data analysis & consulting da-cons GmbH offers analysis, data management, Hermann-von-Helmholtz-Platz 1 archiving and visualisation of large multidimen- D-76344 Eggenstein-Leopoldshafen sional imaging data with a focus on life sciences. Phone: +49 (0) 721/75 40 80 42 The company is located on KIT campus and Telefax: +49 (0) 721/75 40 80 49 Goethe-University campus Frankfurt. [email protected] (data set kindly provided by Christian Mattheyer, Goethe University Frankfurt am Main, BMLS, www.da-cons.de Flexible image data analysis Physical Biology) The high technology service developed by da-cons to obtain temporal and spatial resolution of an Contact person: allows tailored combinations of existing processes object as well as an enormous richness of detail Dipl.-Biol. David Haumann and algorithms in order to analyse multidimension- in microscope images. al imaging data. Customers acquire image data sets Production range/Services: with light or x-ray based imaging systems. Image Customer benefit • Multidimensional image analysis raw data are analysed together with da-cons in Customers do not have to adjust to hardware • 3D Imaging in light sheet individually tailored image processing workflows and software requirements, they can focus microscope (see figure below, box 2). The desired information, principally on their individual problem and the • Data management contained in the image raw data, is extracted and corresponding experiments. They save invest- • Data archiving given back to the customer. ments in hardware, software and manpower. • Cluster computing

Cluster computing allows fast complex Examples from light sheet microscopy Fields of action: image analysis workflows Via cooperation with partners we can offer light • Analytics Thanks to cooperation with several computer sheet microscopy, visualisation and analysis from • Bioinformatics centres, the processing of large data amounts one hand. Analysis of 3D cell cultures, spheroids requires less time. This allows, e.g. in the con-text (see figure above). Tissues or roots from plants is of biological experiments, to examine dynamics possible. This can be done even with intranspa- and development of organisms. Via analysis of rent samples like human skin to evaluate blood these multidimensional data sets, da-cons is able capillary networks or elastin fibers.

69 BIOPRO Baden-Württemberg

DIARECT AG DIARECT AG Bötzinger Str. 29 B DIAgnostics by RECombinant Technology D-79111 Freiburg Phone: +49 (0) 761/47 97 90 DIARECT AG is a privately owned biotech Telefax: +49 (0) 761/47 97 929 company established in 1998. DIARECT‘s [email protected] expertise lies in the development, stand- www.diarect.com ardized large-scale production and worldwide distribution of recombinant and Contact person: native proteins. Dr. Katharina Bonfig The company is not only a leading manufac- Employees: 30 turer of autoimmune and infectious disease antigens, but also the European distributor of Production range/Services: SurModics‘ protein stabilization reagents and Providing customers with products and ser- • Recombinant and native blockers, BioFX substrates and Lumigen che- vices of constantly high quality is one of autoantigens miluminescent detection technologies, thus the cornerstones of DIARECT‘s philosophy. • Infectious disease antigens providing the key components for the deve- Therefore, all products are developed, pro- • Protein stabilizers and blockers lopment of diagnostic end products. duced and distributed according to a Quality • Colorimetric and chemilumines- Today DIARECT serves customers in more Management System that is certified for com- cent substrates than 40 countries worldwide. pliance with ISO 9001 and 13485 standards.

Fields of action: • Diagnostics • Production Organisms • Proteins/Peptides • Supplier

70 DSM Nutritional Products

GmbH Grenzach Emil-Barell-Str. 3 D-79639 Grenzach-Wyhlen Phone: +49 (0) 7624/90 90 Telefax: +49 (0) 7624/90 93 805 [email protected] www.dsm.com

Contact person: Dr. John Buckingham

Production range/Services: • Micronutrients • Life Sciences

Fields of action: • Agriculture/Food • Custom Production DSM – Bright Science. Brighter Living.™ in global markets such as food and dietary supplements, personal care, feed, pharmaceuticals, Royal DSM N.V. is a global science-based com- medical devices, automotive, paints, electrical pany active in health, nutrition and materials. and electronics, life protection, alternative energy By connecting its unique competences in Life and bio-based materials. DSM’s 23,500 emplo- Sciences and Materials Sciences DSM is driving yees deliver annual net sales of around € 9 billi- economic prosperity, environmental progress and on. The company is listed on NYSE Euronext. social advances to create sustainable value for all stakeholders. DSM delivers innovative solutions More information can be found at that nourish, protect and improve performance www.dsm.com.

71 BIOPRO Baden-Württemberg

EMC microcollections GmbH The Company Sindelfinger Str. 3 EMC microcollections GmbH is a biotech D-72070 Tübingen company dedicated to the production of highly Phone: +49 (0) 7071/40 74 0 diverse combinatorial compound collections Telefax: +49 (0) 7071/40 74 22 with drug-like quality for primary screening. [email protected] Based on a wide repertoire of in-house solid www.microcollections.de phase and solution chemistry applying combinatorial techniques and methodologies, EMC Contact person: offers an outstanding range of novel and struc- Dr. Renate Spohn turally complex scaffolds. EMC‘s strong scientific and experimental background supports Employees: 22 lead-optimisation with focussed compound collections. Production range/Services: EMC‘s experts in chemistry, biochemistry and • Parallel chemistry (solid phase biology have expanded the parallel chemistry and solution) process through development and acquisition • Method development and of own targets, biological assays and screening feasibility studies technology. • Organic compound collections • Screening compounds Products Management • Peptides and peptidomimetics EMC‘s business objective is to develop and EMC was founded in 1996 by Prof. Dr. • Immunochemicals provide novel strategies for the drug discovery Günther Jung, Prof. Dr. Jörg Metzger, Dr. process. Our strong knowledge in chemistry Friedrich Stracke and Prof. Dr. Karl-Heinz Fields of action: and the commitment to drug-like quality accel- Wiesmüller based on years-long expertise in • Analytics erate the identification of hits, lead-optimi- automated high-throughput synthesis and • Biotechnological Services sation and up-scaling. EMC offers the full range medicinal chemistry, assay development, pep- • Custom Production of products along the drug discovery process tide and protein chemistry, bioorganic che- • Proteins/Peptides on a servicing or partnership basis: mistry, immunochemistry and combinatorial • customer designed compound collections compound libraries. • protocols for high-throughput synthesis • analytically validated purified compounds • lead structure design and optimisation • nanobiotechnology • regenerative biology and medicine • third generation vaccines • peptide chemistry • immunochemicals

72 The ExploSYS GmbH and its Institute for ExploSYS GmbH Exploratory Systems was founded in 2005 with Otto-Hahn-Weg 6 the aim to provide research and services on D-70771 Leinfelden-Echterdingen the edge between mathematical modelling and Phone: +49 (0) 711/7 56 08 01 policy making. Telefax: +49 (0) 711/7 58 50 11 [email protected] Decision modelling for health economics www.explosys.de ExploSYS brings together biotechnology, economics, epidemiology, statistics and informatics Contact person: to develop cutting edge mathematical model- Dr. Markus Schwehm ling technology capable of realistically assessing health policy and intervention scenarios. The Production range/Services: interactive and high performance simulators and requires a set of advanced software tools: • Computational modelling are used for comparative effectiveness analysis Domain specific languages and graphic editors • Interactive simulation software and risk management, helping to achieve opti- help to express and revise models. Parallel • Parameter sensitivity analysis mal impact on health economics & outcomes simulation and sampling algorithms for deter- • Health economic evaluations research. The ExploSYS experts assist pharma- ministic and stochastic models allow to gene- • Data analysis & visualisation ceutical and biotechnology decision makers on rate a large number of model evaluations. • Bayesian & Markov methods a high scientific level, acting „what-if“ scenarios to the end. This results in reliable planning, Exploratory visualisation, data mining and lower costs and higher margins of safety. reporting help to translate simulation results Fields of action: into arguments for policy making. ExploSYS • Bioinformatics Exploratory modelling and visualisation has successfully applied its exploratory tools to ExploSYS research and services is centred health- and biotechnology-related policy pro- around the concept of exploratory modelling. blems, e.g. for pandemic intervention planning, This iterative and adaptive model develop- for economic evaluation of vaccination strate- ment process involves the handling of a large gies, for risk assessment of antiviral resistance number of models and simulation results or for the optimization of food supply chains.

73 BIOPRO Baden-Württemberg

FRUTAROM

Savory Solutions GmbH Leobener Str. 71 D-70469 Stuttgart Phone: +49 (0) 711/89 99 47 0 Telefax: +49 (0) 711/89 99 40 0 [email protected] www.frutaromsavory.com

Contact person: Dr. Christian Hertel Introduction microbiologists and biotechnologists. The team‘s Frutarom Savory Solutions is one of Europe’s know-how and years of expertise come together Employees: 22 leading manufacturers of meat starter cultures. in our starter cultures. Its continuous R&D efforts have enabled the Production range/Services: company to bring several innovative starter cul- Theory and practice are joined in our International • Starter cultures for food and tures to market in recent years. Starter cultures Technology Center (ITC) – ultimately each starter feed industry for the food industry have been developed and culture has to prove itself in use. We have specialists • Contractual manufacturing manufactured since 1989. and appropriate pilot plant production facilities in Germany and in Parma in Italy. In our pilot plant Fields of action: Frutarom Savory Solutions has its own research facilities we run small scale tests prior to large indus- • Agriculture/Food and development centres for starter cultures. trial trials to fully understand what happens in prac- • Custom Production Both the production of the individual strains as tice, comprehend the quality and the flavour im- • White Biotechnology the complete starter culture is in our hands. To pact. The best results are achieved when the star- ensure everything is harmonized we also offer ter culture is tailored to the end pro duct. Since there complementary ripening agents and seasonings. are numerous types of raw sausages and raw ham This way optimally integrated solutions are devel- with many different regional varieties, we have devel - oped under the one roof – which is unique in oped a wide range of starter cultures as each starter Europe. Our interdisciplinary R&D Cultures culture has its own profile of different properties. Team includes experienced food technologists, The foodstuff and feed market require high standards of product safety and quality. To guarantee this, FRUTAROM Savory Solutions GmbH is certified according to IFS 6.

The focus of our starter cultures is on fermen- ted meat products; however we also produce successfully cultures for agriculture, baking, dairy products and vegetable juice.

74 GATC Biotech AG GATC Biotech AG GATC Biotech is Europe’s leading service provi- Jakob-Stadler-Platz 7 der of DNA sequencing with more than 10.000 D-78467 Konstanz academic and industrial customers worldwide. For Phone: +49 (0) 7531/81 60 68 over two decades, we have offered sequencing and Telefax: +49 (0) 7531/81 60 81 bioinformatics solutions from single samples up to customerservice@gatc- large scale projects. GATC Biotech has sequenced biotech.com more than 5 million samples, ten thousands of www.gatc-biotech.com bacterial, plant and other whole genomes as well as www.facebook.com/gatcbiotech hundreds of whole human genomes. www.twitter.com/gatcbiotech

Having Agilent and Illumina Certified Service Headquartered in Constance, Germany, the com- Contact person: Provider status, GATC Biotech offers true multi- pany houses its ISO 17025 accredited Genome Lisa-Annina Quintes platform sequencing using all leading sequencing and Diagnostic Centre with a focus on Next and technologies in its own labs: Sanger Sequencing Third Generation sequencing. The European Branches: with a fleet of 16 ABI 3730xl, Next and Third Custom Sequencing Centre located in Cologne Subsidiaries in France, Great Generation Sequencing on several Roche GS focuses on Sanger Sequencing and serving as the Britain and Sweden FLX System, Illumina HiSeq 2000, Illumina logistical hub within Europe. All laboratories have MiSeq and Pacific Biosciences’ PacBio RS. highly integrated and fully automatic processing Employees: 140 pipelines and enable full compliance with latest In order to evaluate these immense data quan- state-of-the-art quality standards. Since 2010, Production range/Services: tities professionally, GATC Biotech keeps its GATC Biotech has been a key supplier for the Provider of DNA sequencing own IT farm. It consists of over 160 servers International Cancer Genome Project. services and bioinformatics – that is more than 900 processors in total. In software addition, there is over 1,8TB main memory and GATC Biotech‘s subsidiary LifeCodexx empha- 360TB fix-disk storage available. For instance, sises the development of clinically validated Fields of action: the Illumina HiSeq 2000s generate up to 8TB molecular diagnostic tests and offers a risk-free • Analytics per week of new data which is analyzed by the alternative to common invasive examination • Bioinformatics High Performance Cluster. methods such as amniocentesis. • Biotechnological Services • DNA/RNA

75 BIOPRO Baden-Württemberg

Genaxxon bioscience GmbH Genaxxon bioscience sees itself as a competent Söflinger Str. 100 partner for life science customers who are look- D-89077 Ulm ing for products and services from the molecular Phone: +49 (0) 731/36 08 12 3 biology segment. This understanding is based on Telefax: +49 (0) 731/36 08 96 2 its broad customer base that was built up over [email protected] 11 years of successful business. The company www.genaxxon.com with its headquarter in Ulm is headed by Dr. Norbert Troendle, a biochemist with an MBA Contact person: from the NIMBAS institute in Utrecht. Dr. Norbert Tröndle Genaxxon bioscience with its broad range of with a green dye for real-time PCR. A newer Employees: 5 molecular biology and cell biology products and development is a non-viral transfection reagent services was founded in 2002 by Dr. Norbert for lipofection with siRNA and DNA. To meet Production range/Services: Troendle. The joint expertise of the employees, the needs of our customers, Genaxxon bio- DNA-Polymerases, their laboratory experience and the knowledge science applied for ISO 9001:2008 certification PCR-Mastermixes, qPCR, about product sources enabled Genaxxon devel- and got approval in December 2010. dNTPs, agaroses, growth factors, oping a comprehensive range of products that fit amino acid analysis service, customer needs. To improve product quality and Besides PCR and related products the peptide peptide synthesis service, with that also customer satisfaction high empha- synthesis service and amino acid analysis ser- transfection reagent. sis is put on customer feedback and own quality vice grew to an important part of Genaxxon control. As customers play an important role bioscience business showing that quality and Fields of action: they will not end up at a meaningless hotline accuracy is important and well recognized by • Analytics but will talk directly to one of the competent our customers around the world. • Biotechnological Services stuff at Genaxxon. • Custom Production Products and quality are „made in Germany“- • DNA/RNA Renowned researchers from all over the world due to the focus on regional products, delivery • Proteins/Peptides use Genaxxon products. Quite a number is times are kept as short as possible. This pre- • Supplier mentioned in the scientific literature. serves the environment: short transport routes avoid unnecessary CO2 emissions. While our focus is on molecular biology pro- Last year, Genaxxon BioScience could demon- ducts we have been able to develop new pro- strate its social engagement and donated a ducts like a special hotstart polymerase with sum of money to the local relief operation proof-reading activity or qPCR-mastermixes „Drachenkinder“.

76 Gene Bridges GmbH, founded 2000 as a Gene Bridges GmbH spin-off of the European Molecular Biology Im Neuenheimer Feld 584 Laboratories (EMBL), commercialises the D-69120 Heidelberg patented Red/ET Recombination technology. Phone: +49 (0) 6221/13 70 81 0 Red/ET Recombination, also referred to as Telefax: +49 (0) 6221/13 70 82 9 Ȝ-mediated recombination, allows fast and [email protected] cost-effective modification of DNA molecules. www.genebridges.com

E. coli cells which express phage-derived Contact person: protein pairs, either RecE/RecT from the Rac Gary Stevens (Licensing) prophage or RedĮ/Redȕ from Ȝphage, can pre- Dr. Harald Kranz (Services) cisely alter target DNA by homologous recombination using short (50bp long) homology business areas are „E. coli strain modification/ Employees: 12 arms for the reaction. White Biotech“ and the preparation of complex tailor-made DNA targeting constructs Production range/Services: In May 2004, Gene Bridges opened its which are necessary for the preparation of • Red/ET kits Commercial Centre in the Technology Park in „transgenic mouse models“ in order to analy- • Selection cassettes Heidelberg to offer customers the possibility ze the molecular mechanism of diseases like • DNA engineering services to outsource DNA modification projects. Our cancer or neurodegenerative disorders like team of DNA engineering specialists alrea- Huntington disease. Fields of action: dy performed customer projects for a great • Biotechnological Services number of pharma and biotechnology compa- Companies can alternatively license the tech- • Contract Research nies as well as academic institutes. The main nology for in-house use. • Custom Production • DNA/RNA • Supplier • White Biotechnology

77 BIOPRO Baden-Württemberg

Genotype GmbH Genotype GmbH is dedicated to molecular Angelhofweg 39 biology research and development of D-69259 Wilhelmsfeld innovative products for biotechnology. Main Phone: +49 (0) 6220/5 21 75 20 areas of activity are genomics, high throughput Telefax: +49 (0) 6220/5 21 75 25 DNA analysis and diagnostics, gene synthesis [email protected] as well as dependable methods for the prepara- www.genotype.de tion of nucleic acids.

Contact person: DNA analytical services for industry and aca- Dr. Michael Rieger demic customers started in 1984, establishing the first European company for DNA analyses. Production range/Services: • Genome research Since 1991 Genotype has been participating • Genomics in several international projects on genome • DNA analytical services research. These are mainly EU projects on • DNA sequencing services genome analysis of various model organisms. • Nucleic acids purification products Genotype’s DNA sequencing service includes template preparation, primer design, together Fields of action: with all subcloning steps including DNA libra- • Analytics ry preparation. This applies for small projects • Biotechnological Services such as rapid sequencing of PCR fragments up • DNA/RNA to precise analysis of large chromosomal re - gions or complete genomes.

78 Since more than 30 years in operation, Glycotope Glycotope Biotechnology GmbH Biotechnology GmbH is one of the most-expe- Czernyring 22 rienced and fully GMP-compliant contract manu- D-69115 Heidelberg facturing organisations in Germany. Phone: +49 (0) 6221/91 05 0 Telefax: +49 (0) 6221/91 05 10 We can produce purified batches for precli- [email protected] nical studies and GMP batches for clinical www.glycotope-bt.com phases and commercial batches. With four independent GMP-production suits, Glycotope Contact person: Biotechnology GmbH offers the entire process Dr. Jens Pohl of biopharmaceutical manufacturing from the clone to the drug ready to be administered in Employees: 75 clinical trials. Production range/Services: The GMP-production has meanwhile been In addition to manufacturing capacity, we are • Recombinant proteins increased to a capacity of several kilograms of offering to our clients • Diagnostic kits recombinant antibodies per fermenter unit per • Protein analytical services PHAGOTEST® year. Besides fed-batch fermentation, we are • Validation of methods according to BURSTTEST (PHAGOBURST®) capable of high efficient perfusion fermenta- ICH guidelines BASOTEST® tion technology ranging from 10 to 1000 L, pro- • Cell banking NK TEST® ducing batch sizes up to 12,000 L. Furthermore, • A large variety of bioassays THROMOCYTEST® we offer fill and finish for up to 500 vials/batch • Immune-monitoring of patient samples MIGRATEST® and release of the drug substance. • Quantification of DNA and host cell protein CE-Certified CMV-Kit in pharmaceutical products • Class One MHC-Tetramers

Our immunodiagnostic department offers in Fields of action: vitro test systems, flow cytometry and cell based • Analytics assays for drug screening and target validation. • Biotechnological Services • Cells/Cell Lines Glycotope Biotechnology GmbH has increased • Contract Research from 35 to 75 employees within the last two • Custom Production years and plans to expand even further in the • Diagnostics near future. Together with the parent company, • Production Organisms Berlin-based Glycotope GmbH, Glycotope • Proteins/Peptides Biotechnology GmbH forms the Glycotope • Therapeutics Group with currently 150 employees, repre- senting one of the largest Biotech companies in Germany.

79 BIOPRO Baden-Württemberg

Grafﬁnity Graffinity has built a unique approach to frag- Pharmaceuticals GmbH ment based discovery exploiting label-free low - A Member of the NovAliX Group - affinity surface plasmon resonance (SPR) screen- Im Neuenheimer Feld 518 ing of one of the largest fragment libraries for D-69120 Heidelberg the development of small molecule pharma- Phone: +49 (0) 6221/65 10 0 ceuticals. The SPR array screening platform fea- Telefax: +49 (0) 6221/65 10 11 1 tures a diverse collection of library compounds [email protected] (>116k compounds including >25k fragments www.graffinity.com with MW < 300Da) immobilized on gold chips. Such high density chemical microarrays (9,216 Contact person: sensor fields/array) can be rapidly screened more common classes such as kinases, prote- Dr. Thomas Neumann against any kind of soluble protein target in ases, metabolic enzymes etc., difficult target a label-free manner using our in-house devel- classes including protein-protein interaction Employees: 20 oped SPR imaging instruments. More than 100 (PPI) targets and inherently disordered proteins targets from various protein classes have been have also been addressed. Production range/Services: screened successfully over the past 10 years for Graffinity offers: pharma and biotech customers. In addition to Graffinity benefits from being part of the • Fragment based screening and drug NovAliX group, capable of providing comple- discovery services by high through- mentary biophysical tools for hit optimization put SPR screening of fragment li- and has become a strong partner for early-stage braries and rapid hit-to lead opti- integrated drug discovery. mization using biophysical tools. • The discovery and development The platform is also used for bioseparation of novel affinity ligands for bio- purposes, namely, the development of novel separation/purification of antibo- affinity ligands such as a “universal Fc binder” dies, including a universal (Fc) af- for antibody purification. finity ligand for the purification of antibodies (Protein A substitute) • Drug Discovery • Bioseparation

Fields of action: • Analytics • Contract Research • Proteins/Peptides • Therapeutics

80 Company Description greenovation Biotech GmbH greenovation biotech GmbH is a biopharma- Inselwiesenstr. 10 ceutical company offering production of com- D-74076 Heilbronn plex proteins for the pharmaceutical market as Phone: +49 (0) 761/4 70 99 0 well as IVD and research market employing its Telefax: +49 (0) 761/4 70 99 19 1 proprietary BryoTechnology™. [email protected] www.greenovation.com A GMP production facility is currently furnished at Biomeva, Heidelberg, Germany and will be Contact person: ready for production end of 2013 with one bio- Ms Manon Bartusel pharmaceutical API produced for greenovation’s moss cells. Large scale production is in certified, Phase I/II clinical trial study in Fabry disease. disposable bag-based reactors of the wave-type. A Branches: GMP facility will be ready for production end of Hans-Bunte-Str. 19, Products 2013 at Biomeva, Heidelberg, Germany. 79108 Freiburg, Germany BryokineTM FGF7 The first product ready to market is the recombi- Products will be fully physico-chemically and bio lo - Employees: 19 nant human Keratinocyte Growth Factor (FGF7/ gically characterized in a GMP certified analytic la- KGF) produced by the moss Physcomitrella pa t- bo ratory at PANATecs GmbH, Heilbronn, Germany Production range/Services: ens. FGF7/KGF is a 19 kDa to 28 kDa monome- • Bryokine, e.g. FGF7 ric glycoprotein. As a member of 23 known FGF Clinical Developments and Feasibility studies growth factors, it plays a central role in cell proli- Licensing Opportunities • Prodruction strain development feration, migration and differentiation, as well as greenovation has 2 pre-clinical programs in the • Clinical development homeostasis, response to injury, and tissue repair. area of enzyme replacement therapies (Fabry and • Licensing opportunities Gaucher) under way. • Biosimilars Services • Biopharmaceuticals For feasibility studies greenovation offers a tran- The first GMP manufactured product is the sient production system allowing for quick access alpha-Galactosidase for replacement therapy of Fields of action: to feasibility amounts of high quality protein pro- Fabry patients. The clinical trial phase I/II will • Custom Production duct as well as stable cell line development for a start in spring 2014. • Proteins/Peptides sustainable, cGMP-compliant production of APIs. • Therapeutics greenovation offers production of pharmaceutical All clinical programs are open for licensing proteins in eukaryotic cell systems, utilizing plant opportunities.

81 BIOPRO Baden-Württemberg

Greiner Bio-One GmbH Pioneering Technologies for the Diagnostic Maybachstr. 2 and Pharmaceutical Industries D-72636 Frickenhausen Phone: +49 (0) 7022/9 48 0 Specialists in the fields of biology, chemistry Telefax: +49 (0) 7022/9 48 514 and physics work together for Greiner Bio- [email protected] One BioScience to develop new products and www.gbo.com/bioscience solutions for the highly developed markets in Europe, Asia, and the USA. In the develop- Branches: ment of novel solutions for the future and the Belgium, Brazil, China, France, ongoing optimisation of existing solutions, spe- Japan, Netherlands, UK, USA cial emphasis is given to micros and nanotech- especially aimed at genotyping. The DNA-array nologies, in order to assure through increasing PapilloCheck ® for the simultaneous genotyping Employees: 360 miniaturization, right down to biochip techno- of 24 different types of human papilloma virus

Production range/Services: logy, the utmost efficiency for biomedical and (HPV) is a successful example therefore. The • DNA-arrays for diagnostics and basic research. The sequencing of the human biochip is an in-vitro diagnostica for the qua- analytics genome has enabled the early identification litative detection of human papilloma viruses ® • MICROLON , FLUOTRAC™, of diseases such as cancer, AIDS and diabetes, in clinical specimens. With it, medical labora- LUMITRAC™, UV-Star® and as well as more effective diagnosis of viral and tories and clinics will benefit from a specific μClear® microplates and stripwells for specialized immu- bacterial infections, and the development of identification of the causative agent for cervical noassay investigations suitable medicines and therapies. In collabo- carcinoma. • 96, 384 and 1536 well micro- ration with Lambda GmbH, Greiner Bio-One plates for high-throughput BioScience is currently developing biochips www.gbo.com/bioscience screening and other multiwell applications • CELLSTAR®, Advanced TC™ and CELLMASTER™ cell culture products • CELLCOAT® coated surface plastics • CRYO.S™ cryogenic storage tubes and datamatrix cryo rack • Labware

Fields of action: • Diagnostics • Supplier

82 Modern diagnostic systems help cure Hain Lifescience GmbH Hain Lifescience GmbH, founded in 1988, is Hardwiesenstr. 1 the manufacturer and distributor of molecular D-72147 Nehren diagnostic systems. The cornerstone of the Phone: +49 (0) 7473/94 51 0 company was laid in 1986 by the two brothers Telefax: +49 (0) 7473/94 51 31 David and Tobias Hain. The focus of the com- [email protected] pany today is the independent development, www.hain-lifescience.de production and distribution of modern diagnostic test systems and lab equipment. With Contact person: these products definite statements can be made, and development and the innovative products Michael Wirth for example about the presence of hereditary of high quality resulting from it. Close coope- diseases. Other test systems are used to identify ration with leading universities and reference Branches: bacteria which cause diseases such as tuberculo- centers guarantee timely transfer of recent sci- Spain, South Africa, East Africa sis, MRSA or other serious infections. entific knowledge into products for routine use. and Kenya, UK Since the company attaches great value on the Based on the continuous expansion of the inspected quality of their products, comprehen- Employees: approx. 90 company’s facilities, Hain Lifescience currently has sive quality control as well as the certified qua- more than 90 employees in Nehren in the district lity management according to ISO 9001/13485 Production range/Services: of Tübingen. Additional expansion steps included and the fulfillment of the European in-vitro diag- • Diagnostic test systems and the establishment of subsidiaries in Spain, South nostics guidelines are standard. This allows the lab equipment Africa, East Africa and Kenya, and UK. company to always keep the product portfolio in line with the most current state of knowledge Fields of action: The continuous company growth is in particular and developments, and thereby to constantly • Diagnostics due to substantial capital investment in research improve customer service. • DNA/RNA • Supplier

83 BIOPRO Baden-Württemberg

HB Technologies AG Since 2008, the INTAVIS Bioanalytical Instruments Paul-Ehrlich Str. 5 AG in Cologne is a subsidiary. The product lines D-72076 Tübingen of INTAVIS AG include laboratory instruments Phone: +49 (0) 7071/97 61 1 with a focus on peptide synthesis and in situ Telefax: +49 (0) 7071/97 61 90 hybridization. Furthermore INTAVIS offers [email protected] Custom Peptide Services and sells Resins. These www.h-net.com services complement the portfolio of HB Techno- logies AG and offer additional value for existing Contact person: and potential customers. Dr. Steffen Hüttner HB Technologies portfolio covers the

Branches: Cologne, Heidelberg, following modules Reutlingen (GER), Chicago (USA) HB Technologies AG is one of the largest • Production Software, Process Optimization for in- software companies concerning Life Science dustrial research facilities in Oligonucleotide, Pep- Employees: 32 and Engineering issues in the southern part of tide, Antibody, Bio-Assay and Genomic Analytics Germany. HB Technologies has expertise in con- Production range/Services: sulting and developing technical software solutions • Workflow Management Software for industrial • Software for Workflow since 1992 and a wealth of experience with over and research labs in cooperation with Robert Management 450 projects in the mentioned areas. Due to active Bosch GmbH • One-stop solutions for research participation in a number of research projects sup- laboratory instruments ported by state and federal government, existing • Engineering and Manufacturing for • Production Systems for oligos skills and services are continuously expanded. instruments and devices and peptides • Bio Assays The company is a software expert for automated • Bioinformatic Services mainly for sequencing • Bioinformatic Services e.g. production processes in industrial and research data (from standard evaluations up to complex analysis for sequencing data laboratories as well as laboratory instruments in pipelines) • Databases general. In addition HB Technologies is a com- • Validation for pharmaceutical petent partner for questions in development, • Lab Research Instruments for applications in and medical technologies programming and testing software and electronic PCR, Online-PCR, Liquid-handling, Bio- and • Consulting components in the automotive division. Medical tests

Fields of action: • Bioinformatics • Biotechnological Services • Custom Production • DNA/RNA • Proteins/Peptides

84 Heidelberg Pharma is a pharmaceutical company Heidelberg Pharma GmbH with a dual business model: Preclinical services Schriesheimer Str. 101 in pharmacology and bioanalytics as well as deve l- D-68526 Ladenburg opment of drugs to treat cancer. For investigating Phone: +49 (0) 6203/10 09 45 PRE-CLINICAL SERVICES Telefax: +49 (0) 6203/10 09 76 4 compounds in an exploratory way, our flexibility DRUG PROFILING & BIOANALYTICS allows customized experimental designs and the CANCER AND INFLAMMATORY DISEASE [email protected] development and validation of new models besides www.heidelberg-pharma.com a range of routinely used test systems. For in vitro profiling, we have over 100 tumor cell lines avail- Contact person: able in-house. Multiple human tumor xenograft Prof. Dr. Andreas Pahl models are in routine use at Heidelberg Pharma. Efficacy can be determined in tumors differing Employees: 39 in growth rate, response to clinical standards or IN THE “COURT OF ROSES” LADENBURG NEAR HEIDELBERG RHEIN-NECKAR TRIANGLE expression of selected target proteins. Moreover, Production range/Services: we have established a range of mechanistic and • Pre-clinical services disease models for the characterization of anti- • Antibody drug inflammatory drug candidates. Our bioanalyti- service provider, the company has developed an conjugates (ADC) cal service program includes plasma and tissue entirely new technology for the design and devel- pharmacokinetics, tissue distribution- and opment of antibody-drug-conjugates. The tech- Fields of action: mass balance studies using radiolabeled com- nology is based on access to a specific toxin that • Analytics pounds. State-of-the art lab equipment and SOP is coupled to antibodies. The approach offers • Biotechnological Services controlled processing ensure high quality and re- new perspectives for treating cancer patients that • Cells/Cell Lines producible data, which are reported according to have become resistant to conventional treatment • Contract Research regulatory standards. Besides being a preclinical and with tumor metastasis. • Proteins/Peptides • Therapeutics

HPLC with autosampler and -MS/MS Masspectrograph (Agilent/Applied Biosystems)

85 BIOPRO Baden-Württemberg

HiSS Diagnostics GmbH Güterhallenstr. 3 D-79106 Freiburg Phone: +49 (0) 761/38 94 90 Telefax: +49 (0) 761/38 94 920 [email protected] www.hiss-dx.de

Contact person: Georg Klopfer, Dr. Christina Schäfer HiSS Diagnostics GmbH is offering a wide • Enzymes and master mixes for PCR, RT-PCR, Employees: 12 range of products in diagnostics as well as in qPCR and other reagents for molecular bio- life science. HiSS Diagnostics was founded in logy, western blot detection and protein Production range/Services: 1989, is privately held and located in Freiburg, biochemistry Diagnostics: Germany. We are qualified for DIN EN ISO • Transfection reagents for DNA, siRNA and • molecular testing for leukemia 13485:2003, under CAMCAS. peptides for in vitro and in vivo applications & lymphoma • Antibody and filtration based kits for gentle, • in vitro diagnostics Main focus in diagnostics are products for fast and simple cell separation from whole Life Science: molecular testing for leukemia and lympho- blood, buffy coat or cell suspensions without • NGS library prep kits for all ma. Additionally we offer PCR and ELISA magnetic beads or centrifugation major platforms tests for microbiology and virology. Our port- • Non-toxic immunization adjuvant as alterna- • monoclonal & polyclonal antibodies folio is completed by quality control material tive to Freund’s complete adjuvant • ELISA kits for human, mouse & rat for blood banks, transfusion centers and viro- • transfection reagents logy labs. • cell isolation in 10 min. • non-toxic immunization adjuvant For life sciences HiSS Diagnostics offers: Services: • Next Generation Sequencing Library Prepa- • Custom antibody production ration Kits (gDNA, Amplicons, mRNA, small RNA) compatible with Illumina HiSeq Fields of action: and MiSeq as well as Ion Torrent PGM • Analytics and SOLiD • Cells/Cell Lines • Antibodies for Alzheimer’s and neurodegene- • Custom Production rative diseases, cell biology, immunopatho- • Diagnostics logy and against epitope tags • DNA/RNA • ELISA kits for human, mouse and rat cytokine • Proteins/Peptides detection as well as recombinant cytokines, • Supplier chemokines and growth factors

86 Hydrotox GmbH Hydrotox GmbH Bötzinger Str. 29 Hydrotox GmbH, founded in 1989, is a D-79111 Freiburg GLP-certified contract laboratory for carrying Phone: +49 (0) 761/4 55 12 0 out studies involving biodegradability, Telefax: +49 (0) 761/4 55 12 34 ecotoxicity and genotoxicity of substances, [email protected] complex mixtures and environmental samples. www.hydrotox.de Beside routine studies for chemical registration, flow management. Our clients are chemical e.g. in compliance with EU and OECD stand- industry, pharmaceutical companies, textile Contact person: ard guidelines and directives as well as EN and industry, construction material manufacturers Dr. Stefan Gartiser national standards, Hydrotox also performs and others. research projects for industry and public insti- Employees: 10 tutions and is board of expertice for environ- Coordinating closely with our clients and the mental labels. regulatory authorities and agencies, Hydrotox Production range/Services: works out the right solution for the task in Environmental risk assessment The main focus of research activities is on the hand. Systematic investigation strategies based GLP-studies concerning assessment of chemical substances, products on comprehensive research, the scientific and ecotoxicology, biodegradability and wastewater as well as on the integration economic assessment of all parameters and and mutagenicity of laboratory tests in product development, extensive documentation lead to ecologically the optimization of processes and material and economically convincing results. Fields of action: • Analytics • Contract Research • Environmental Biotech

87 BIOPRO Baden-Württemberg

IBAM GbR Dr. Rainer Knörle Founded in 1996 as a spin-off of the Neuro - & Dr. Peter Schnierle pharmacology section at the University Freiburg, Ferdinand-Porsche-Str. 5 IBAM is a privately owned laboratory for con- D-79211 Denzlingen tract research in (phyto-)pharmacology. Our Phone: +49 (0) 7666/88 45 75 8 expertise includes customised binding assays, Telefax: +49 (0) 7666/88 45 76 0 cellular and tissue assays for various enzymes, [email protected] transporters, receptors and ion channels. www.ibam.de Pharmacological investigation of drugs Contact person: We offer the characterisation of the pharmaco- Dr. Rainer Knörle logical profiles of chemical substances and plant extracts. Based on this knowledge, drug effects Production range/Services: may be explained and new drugs and indica- Western society since the turn of the century • Drug mode of action tions may be found. and allowed for a rise in the demand for natural • Drug discovery and development medicines. Most medicinal plants are used tradi- • Receptor binding assays IBAM provides several models to study drug- tionally without the knowledge of their pharma- • Functional assays induced modulation of hormone and neurotrans- cological action. • Hormone and neurotransmitter mitter release and uptake. We perform experi- uptake and release ments into binding of substances (drugs, plant We test plant extracts for their potential physi- • Enzyme inhibition assays extracts, etc.) to specific binding sites at receptors, ological or pharmacological activity by studying • Melanin affinity of drugs other proteins and biopolymers like melanin. their effects on hormone or neurotransmitter • CNS active plant extracts turnover, receptor binding or enzyme activities. Screening for pharmacologically active Several plant extracts with pharmacologically Fields of action: plant extracts confirmed medicinal benefit were identified. • Analytics Medicinal plants are used in folk medicine for • Biotechnological Services centuries. The rejection of synthetic or biome- • Contract Research dical products has become a growing trend in • Therapeutics

88 ibt – Immunological and ibt – Immunological and

Biochemical Testsystems GmbH Biochemical Testsystems GmbH Wiesenstr. 17 ibt develops, manufactures and distributes im- D-88521 Binzwangen munological reagents: recombinant proteins and Phone: +49 (0) 7371/95 22 00 0 antibodies (e.g. infectious diseases, transcription Telefax: +49 (0) 7371/95 22 00 7 research, hormones, enzymes, growth factors and [email protected] cytokines). A new focus is on development, www.ibtsystems.de manu facturing and distribution of immunoassay kits for Insulin-like Growth Factors (IGF‘s) and Contact person: Insulin-like Growth Factor Binding Proteins Dr. Lothar Seik (IGFBP‘s) and related molecules. Biotinylated IGF‘s and IGFBPs´ are available as well as a custom Production range/Services: biotinylation service. Applications of biotinylated • Recombinant proteins IGFs´ (and other peptides) are in western-ligand ibt participates in the BIOSCENT project within • Monoclonal and polyclonal blottting, ELISA, protease assays, IHC, immuno- the European Community‘s Seventh Framework antibodies precipitation, cross-linking, cell sorting, immu- Programme. In this project ELISA kits have been • Immunoassay kits nohistochemistry and experimental cell therapy. developed for the detection of SDF-1 alpha in • Ligand blotting kits A new research focus is on tissue engineering. human, rat and mouse samples. Fields of action: • Analytics • Custom Production • Diagnostics • Supplier • Proteins/Peptides • Tissue Engineering

89 BIOPRO Baden-Württemberg

immatics biotechnologies GmbH Paul-Ehrlich-Str. 15 D-72076 Tübingen Phone: +49 (0) 7071/53 97 0 Telefax: +49 (0) 7071/53 97 90 0 [email protected] www.immatics.com

Contact person: Paul G. Higham, CEO

Branches: Munich, Germany

Employees: 70 FTE immatics biotechnologies is a clinical-stage (TUMAPs) with the ability to specifically stimu- biopharmaceutical company developing ad- late the immune system against cancer cells. Production range/Services: vanced therapeutic vaccines that are active These vaccines – comprising multiple peptides immatics is currently developing against cancer. immatics’ lead product IMA901 confirmed to be naturally presented by real tumor three multi-TUMAP products in is in a Phase III clinical trial in renal cell tissue – offer the prospect of greater effectiveness clinical studies – IMA901 for the carcinoma and has completed its patient than existing cancer vaccine approaches combined treatment of renal cell carcinoma recruitment in Nov. 2012. immatics’ pipeline with fewer side effects. immatics’ products are (RCC) in a clinical Phase III study also includes IMA910, in Phase II for colorec- ‘drug like’ with stable, off-the-shelf formulations (patient recruitment completed), tal cancer, and IMA950 which is being deve- and robust easily scalable manufacturing. IMA910 for the treatment of colorec- loped for glioma. tal carcinoma (CRC) in Phase II and immatics is based in Tuebingen and Munich, IMA950 in collaboration with part- immatics’ technology platform rapidly generates Germany, and has raised more than €100 mil- ners for the treatment of brain cancer defined therapeutic cancer vaccines which are lion (US$130 million) in private equity in three (glioblastoma) in Phase I. Further based on multiple tumor-associated peptides financing rounds. product candidates like IMA941 for the treatment of gastric cancer and a project for treatment of non-small cell lung cancer patients are currently in pre-clinical development.

Fields of action: • Proteins/Peptides • Therapeutics

90 Insilico Biotechnology AG Meitnerstr. 8 D-70563 Stuttgart Phone: +49 (0) 711/46 05 94 0 Telefax: +49 (0) 711/46 05 94 10 [email protected] www.insilico-biotechnology.com

Contact person: Klaus Mauch, Vorstand

Insilico Biotechnology AG Employees: 20

Insilico Biotechnology is a market-leading Production range/Services: company providing solutions and software Insilico Professional Services for the simulation of living cells. An inter- • Identification of synthetic disciplinary team of experts offers custom- pathways for new bioproducts ised solutions for the efficient manufacturing • Identification of multiple of biotechnological products and for the gene-targets for improved development of drug test systems by using product yields high-performance computing and Insilico‘s • Optimization of media/feeding proprietary software. For world-leading com- • Prediction of long-term toxicity panies from the chemical and pharmaceutical Insilico Databases and Software industries, Insilico‘s technology lowers time, • Repository of prokaryotic and risk and costs of development processes. eucaryotic insilico strains Founded in 2001, Insilico is a privately held • Organ models company based in Stuttgart, Germany. • Enterprise software for systems- oriented process analysis • Software Development • Drug Testing

Fields of action: • Bioinformatics • Contract Research • Therapeutics • White Biotechnology

91 BIOPRO Baden-Württemberg

Jobst Technologies GmbH Jobst Technologies is a young technology Additional activities are contract research and Engesserstr. 4b orientated enterprise offering its core compe- development for medical device manufacturers D-79108 Freiburg t encies in the overlap between micro systems as well as product development for life science Phone: +49 (0) 761/55 77 52 0 technology and (bio)electrochemical analytics applications. Telefax: +49 (0) 761/55 77 52 2 both as service and products to his customers. [email protected] “Rational technology integration aiming at bio- www.jobst-technologies.com Our expanding product portfolio encompasses micro convergence“ is a slogan created by Gerhard sensors for cell adhesion, methanol, hydrogen Jobst, founder and CEO of Jobst Technologies. Contact person: peroxide, ethanol and oxygen, biosensors for glu- Gerhard Jobst cose, pyruvate, glutamate, glutamine and lactate. The company is partner in national and inter- We also offer microfluidic systems such as static national research projects in the fields of multi- Employees: 5 micromixers, complete monitoring solutions com- parameter monitoring for applications like drug prising of sensor arrays, microfluidics, electronics, screening or in cancer research at low oxygen Production range/Services: and software, and robotic dispensing systems for tension conditions. An additional European Biosensors for glucose, L-lactate, smallest volumes. The products are intended for project focuses on integrated optics. L-glutamine, and L-glutamate, clinical applications in the intensive clinical care L-pyruvate; sensors for oxygen, unit and for point of care application, for cell The flexibility of our technology portfolio not

H2O2; cell adhesion. Any combina- culture monitoring in biotechnology and for only ensures development and production at tions of the sensors – flow through environmental monitoring. Low flow rate multi- competitive costs but also allows realisation of or dip in format – and internal parameter monitoring at nl-volumes is one out- cost effective customised solutions for clinical volumes as low as 80 nl are pos- standing specialty the company offers. diagnostics and biotechnological applications. sible. Application: cell culture or clinical multiparameter monitoring.

Fields of action: • Analytics • Custom Production • Diagnostics • Environmental Biotech

92 Junker Filter GmbH Junker Filter GmbH Carl-Benz-Str. 11 Since the mid-50s Junker-Filter GmbH is suc- D-74889 Sinsheim cesful within the branch filtering mediums for Phone: +49 (0) 7261/92 83 0 dust filtration and solid/liquid separation. Telefax: +49 (0) 7261/92 83 99 [email protected] We number well-known companies among our www.junkerfilter.de longterm and continuous growing customer base from the following industries. Contact person: • implementation of practical concepts and Jürgen Junker • Chemical industry, pharmaceutical industry, new technologies in solid-/liquid separation food processing industry and beverages as well as in residue treatment Employees: approx. 100 • Power generation and dust separation • new development of the patent-registered sys- • Steel + Metal + Metallurgy tem “BEGA” = Biological-Electrical Gas Cleaner, Production range/Services: • Automotive industry which sets a new procedural standard for redu- • BEGA = Bioelectrical • Municipal and industrial waste water treatment cing odors and for the degradation performance Gas Cleaner • Recycling of VOC (volatile organic compounds) • Simultaneaous separation of dust and odor by combining an elec- Intensive research and development characterizes Junker Filter offers a wide range of service trical separator and a biofilter our work. Whereby the existent product range is and maintenance works around filter tech- continuously adjusted by developing procedures nology. We are the best contact, no matter Fields of action: and new products to supplement the actual pro- whether you are planning new filter con- • Environmental Biotech duct portfolio. Of particular importance are: cepts or improving existing filter systems. • tailor-made filter concepts for state-of-the-art Furthermore flexibility, know-how, continous dust filtration – our contribution to the main- innovation and umcompromising quality tenance of a clean environment completes our profile.

93 BIOPRO Baden-Württemberg

LABOR DR. MERK & KOLLEGEN

GmbH Beim Braunland 1 D-88416 Ochsenhausen Phone: +49 (0) 7352/91 19 30 Telefax: +49 (0) 7352/91 19 40 [email protected] www.labormerk.de Labor Dr. Merk & Kollegen GmbH (LMK) was Association for the Control of Virus Diseases), Contact person: founded in 1971 and holds excellent expertise in LMK offers antiviral efficacy testing of disinfec- Dr. Ingrid Rapp biosafety testing for virology, microbiology and tants for human and veterinary use. toxicity of intermediates or final products from Employees: 45 pharmaceutical industries or medical device In addition to standard microbiological methods, manufacturers. A wide range of GMP and GLP cleaning and steam validation studies of medical Production range/Services: compliant methods for preclinical studies or devices are offered. • Biosafety testing (GMP and GLP) quality control of final product testing is availa- • Validation of manufacturing pro- ble. Stability testing of veterinary vaccines is The company has been operating since the begin- cess steps for virus elimination an additional service for pharmaceutical indus- ning in the in vitro diagnostic fields like virology or inactivation tries. Since 2008, LMK is authorized by the and microbiology of infectious disease serology. • Extraneous agent testing; Testing Regierungspräsidium Tübingen to perform GMP LMK is certified according to DIN EN 13485 and of disinfectants for antiviral and compliant services for viral, mycoplasma and DIN EN ISO 9001:2008 for the production of in antimicrobial efficacy microbial contamination testing. vitro diagnostic devices and research reagents. LMKs´ • Microbial cleaning or steam laboratories develop, design and manufacture test sterilization validation studies Validation of manufacturing process steps for kits and reagents, also on customer request. • In vitro toxicity testing virus elimination or inactivation, testing of • Development and production substances for antiviral activity or extraneous LMK cooperates with companies, universities of In vitro diagnostics agent testing of materials of animal or cell cul- and research institutions to generate expert ture origin are available with a broad range of experience and exchange of know-how. With Fields of action: human or animal pathogenic virus/cell systems. our well experienced team we are prepared to • Analytics Since 2005, as member of the expert commit- meet the customers‘ needs with appropriate • Biotechnological Services tee “virus disinfection” of the DVV (German and innovative solutions. • Cells/Cell Lines • Custom Production • Diagnostics • Production Organisms • Proteins/Peptides

94 Labor für DNA-Analytik Labor für DNA-Analytik Klarastr. 66 Labor für DNA-Analytik was founded in 1993. D-79106 Freiburg It supports scientists involved in molecular Phone: +49 (0) 761/40 79 56 biology and medicine in their research. It Telefax: +49 (0) 761/40 79 56 offers more than 25 years of experience in [email protected] DNA- analysis and research in molecular bio- www.dna-analytik.de logy. Main activities are focused on: PCR based pathogen detection in human samples, cloning, Contact person: development of new PCRs according to the Dr. Juliane Alt-Mörbe customer‘s need, DNA sequencing including sation (FISH), STR-based analysis of human primer design and mutation analysis, cDNA samples, paternity testing, species identification Employees: 2 synthesis, cloning, fluorescent in situ hybridi- by DNA barcoding. Production range/Services: Services in molecular biology: PCR, PCR-based identification of pathogens, DNA sequencing and cloning, FISH, STR profiling, paternity tests, identification of cell lines

Fields of action: • Analytics • Biotechnological Services • Diagnostics • DNA/RNA

95 BIOPRO Baden-Württemberg

Logopharm GmbH Schlossstr. 14 LOGOPHARM GmbH is a biotech company D-79232 March-Buchheim that provides specialized services in proteomic Phone: +49 (0) 761/2 03 51 27 target and biomarker R&D with independent Telefax: +49 (0) 761/2 03 51 91 discovery projects for CNS indications. The [email protected] company located in Freiburg (Germany) was www.logopharm.com founded by a team of scientists and business experts. It combines proprietary proteomic Contact person: technologies, long-term experience in functio- Dr. Uwe Schulte nal membrane protein analysis and innovative drug development concepts with a focus on Branches: 1 in Freiburg (GER) membrane proteins and protein complexes. Our proprietary developments include the Employees: 5 CompleXio technology for the identification of protein-protein interactions in native tis- Production range/Services: sue, microproteomic analysis with ultimate • Proteomic services (membrane sensitivity and label-free quantitative mass protein purification and spectrometry. The used strategies are broadly implementation of technology, individually characterization) applicable to targets and biomarkers, require adapted to our customers’ needs. In addition, • Mass spectrometry (label-free very small amounts of sample and show a we have established research collaborations quantification, PTM-analysis) lower error rate than current high-throughput with distinguished academic and commercial • Technology development approaches. Based on this we offer advanced partners to promote our technology and inde- • ComplexioLyte detergent buffers proteomic services, research consulting and pendent development projects. • Validated antibodies

Fields of action: • Analytics • Bioinformatics • Biotechnological Services • Contract Research • Supplier • Proteins/Peptides

96 Mediagnost Mediagnost GmbH Aspenhaustr. 25 Mediagnost Company (GmbH) is a leading D-72770 Reutlingen company located in the Technologie-Park Phone: +49 (0) 7121/5 14 84 0 Tübingen-Reutlingen that develops, manu- Telefax: +49 (0) 7121/5 14 84 10 factures and markets innovative biomedical [email protected] diagnostics and raw products like monoclonal www.mediagnost.de antibodies and antigens for pharmaceutical companies. Contact person: Dr. Lutz Pridzun Mediagnost operates through direct offices in Germany and in the United States (Mediagnost Branches: of America, Phoenix, Arizona) and through a Mediagnost of America, Phoenix, network of distributors worldwide. USA Mediagnost was formed in 1985, its primary purpose was to commercialize antigen and Production range/Services: antibodies to pharmaceutical companies. Since Diagnostics in endocrinology and 1985 Mediagnost has largely extended and infectious diseases: ELISA, RIA, its main focus lies on designing innovative Multiplex, PCR, ligand binding assa- diagnostic tools (Endocrinology, Diagnostic ys, reagents and raw material, cell of infections, Nucleic Acid Technology, culture service, diagnostic service Nanotechnology) in a swift transfer from the scientific research base directly to the customer. Fields of action: • Diagnostics • Biotechnological Services • Custom Production • Contract Research • Cells/Cell Lines • Production Organisms

97 BIOPRO Baden-Württemberg

MEDICHEM Diagnostica MEDICHEM has access to an experience of more GmbH & Co. KG than 20 years in development and production of Kringstr. 3-5 in-vitro diagnostic products. The office is located D-71144 Steinenbronn in Steinenbronn, close to the Stuttgart Airport. Phone: +49 (0) 7157/53 04 0 The quality management system of MEDICHEM Telefax: +49 (0) 7157/53 04 11 Diagnostica GmbH & Co. KG is certified accor- [email protected] ding to EN ISO 9001 and EN ISO 13485. www.medichem.de The foundation of MEDICHEM Diagnostica MEDICHEM provides reference material for in- Contact person: has been made by Atou Khalide Lô in 1986. At ternal accuracy and precision testing. Precision tes- Mr. Insa Lô that time it was a sole proprietorship. In 1998 his ting focuses mainly on the longitudinal expansion son Insa Lô joined the company as a partner, he of the single control test within the quality control Employees: 14 finally became managing director in 2004. Now, batch, i.e. a specific concentration range next to MEDICHEM Diagnostica employs 14 permanent legal or generally applicable boundary values. Production range/Services: workers and additionally several freelancers in In-vitro diagnostic research and development affairs. Accuracy testing materials are additionally used Reference material for internal to review the compliance level of the indivi- accuracy and precision testing dual measurement result with the real value (whole blood, serum, urine, hair) of the indicator. The compliance level has to be evaluated trustworthy by a minimum of Fields of action: representative testings with validated, mostly • Analytics internal standardized and evident methods, • Custom Production especially proficiency tests. • Diagnostics • Supplier For internal accuracy testing MEDICHEM provides both accuracy test samples as well as selected proficiency test samples, taken from proficiency tests for well-known professional medical associations i.e. DGKL (German Society for Clinical Chemistry and Laboratory Medicine) or GTFCh (Society of Toxicological and Forensic Chemis- try). This happens after the evaluation of the respective proficiency test and the successive result approval of the proficiency test authority. Those proficiency tests can therefore be used as reference test samples, currently the reference material most suitable and characterized best for forensic-toxicological analyses.

98 New in vitro Assays: Medicyte GmbH Medicyte is a life science company specialized in Im Neuenheimer Feld 581 the controlled generation of high quality human D-69120 Heidelberg primary cells in virtually unlimited quantities. Phone: +49 (0) 6221/7 29 25 30 Medicyte’s proprietary technologies, upcyte® and Telefax: +49 (0) 6221/7 29 25 31 vericyte®, for the first time enable the production [email protected] of commercially available standardized human www.medicyte.com cells from different donors. There is a growing list of companies using upcyte® cell strains and Contact person: vericyte® cells as an alternative to current in vitro Stefan Holder models for cell-based R&D. Managing Director upcyte® cell strains – the better alternative: Employees: 18 Medicyte is establishing its proprietary products as gold standards and the preferred source of Production range/Services: human cell-based products for research, industri- 2. Therapeutic applications in • Novel cell assays e.g. for al and therapeutic applications. Key applications regenerative medicine: ADME-Tox for Medicyte’s products are: • Development of novel primary cell therapies • upcyte® and vericyte® cells in for liver and bone regeneration. superior quality and virtually 1. Cell assays for drug discovery & unlimited quantity development and basic research: 3. Non-pharmaceutical applications: • Cell therapeutic co-development • Replacement of cell lines and existing primary • Models for toxicity screening in the chemical • Primary cell media and cell cell models with standardized upcyte® cells. and cosmetics industry (REACH). culture products • Novel high end primary cell models for pharmaceutical industry, e.g. in vitro ADME-Tox. Further information can be found at Fields of action: • Customized production of upcyte® cells. www.medicyte.com • Cells/Cell Lines • Custom Production • Supplier • Tissue Engineering

99 BIOPRO Baden-Württemberg

menal GmbH menal GmbH is a GLP/GCP conform analytical Gesellschaft für medizinisch natur- lab, based in Emmendingen near Freiburg. wissenschaftliche Laboranalyik Im Hausgrün 15 Over a period of more than 20 years, menal has D-79312 Emmendingen built up and established a strong partnership Phone: +49 (0) 7641/93 33 46 with the pharmaceutical industry, specialising Telefax: +49 (0) 7641/93 33 489 in bioanalytical research into pharmacokinetics [email protected] and pharmacodynamics. www.menal.de Individuality and flexibility distinguish our Contact person: laboratory from others. Personal contact and Tobias Engelmann, fast processing are our priority, which enable Dr. Peter Engelmann our customers worldwide to easily keep up with advancing developments. Highest quali- Employees: 12 ty analyses “performed in Germany” include analytics for clinical studies according to Production range/Services: GCP/GLP, analytics for pre-clinical studies • Collagen-R in different concen- (Toxicology), analytics for pharmacodynamics trations for cell culture use and pharmacokinetics and quantitative analysis • Analytics for clinical studies of active pharmaceutical ingredients/metabo- according to GCP/GLP lites in biological matrices. LC/MS/MS methods • Analytics for pre-clinical and different bioassays can be performed. studies (Toxicology) • Analytics for pharmacodynamics As a manufacturer of sterile Collagen-R in and pharmacokinetics different concentrations for cell culture, menal • Quantitative analysis of active are distributing their products worldwide. pharmaceutical ingredients/ metabolites in biological matrices • Method development • Method validation • Reporting

Fields of action: • Analytics • Biotechnological Services • Supplier • Proteins/Peptides

100 MetaSystems is an employee-owned German MetaSystems GmbH company specializing in automated scanning Robert-Bosch-Str. 6 and image analysis for cytogenetics, cancer D-68804 Altlussheim genetics, toxicology, pathology, forensic sci- Phone: +49 (0) 6205/3 96 10 ences and other applications. MetaSystems is Telefax: +49 (0) 6205/3 22 70 based on more than 26 years of experience in [email protected] image analysis and automated microscopy. This www.metasystems.de background ensures MetaSystems being at the Contact person: forefront of technology. Today, more than 1,600 Dr. Andreas Plesch laboratories in over 80 countries rely on the quality and stability of MetaSystems products. cases, importing and exporting case and image Branches: data to other data management systems, and the Altlussheim (50 employees) MetaSystems is the manufacturer of the renow- generation of informative reports and statistics Boston (12 employees) ned slide scanning platform Metafer, an innova- queries is easily possible. Hereby data integrity Hong Kong (12 employees) tive system for unattended automated microsco- is guaranteed by MetaArchive, the professional Bangalore (2 employees) py imaging. The system scans up to 800 slides archiving software. The outstanding flexibility of fully automatically, reads bar codes, and provides MetaSystems devices allow the configuration of Employees: 50 extensive tools for automated image enhance- highly professional multi-user workplaces. ment and analysis. Metafer is the perfect system Production range/Services: to automate clinical cytogenetic imaging (in MetaSystems is proud to offer complete solu- • Automated slide scanning plat- combination with the karyotyping system Ikaros tions for clinical image analyses, including a wide form Metafer for cytogenetics, and the FISH imaging system Isis), to reliably range of high quality DNA probe kits (XCyting toxicology, and pathology evaluate toxicology and radiation biodosimetry Probes). The probe kits portfolio includes chro- • Karyotyping system Ikaros with tests, and to generate high quality digital slides, mosome paints and multicolor FISH probes for integrated case data management e.g. from tissue sections in pathology labs. human, mice, and rat chromosomes, multicolor • Fluorescence imaging chromosome banding probes (mBAND), and a system Isis with modules for Any data obtained with MetaSystems devices are continuously growing number of locus-specific mFISH, mBAND, and CGH organized with the help of the integrated patient probe kits to identify clinical syndromes in hema- • DNA probe kits for multi-fluoro- and case management software. Fast retrieval of tology, pathology, and other domains. chrome analyses and haemato- logy diagnostics

Fields of action: • Analytics • Bioinformatics • Diagnostics • DNA/RNA • Supplier

101 BIOPRO Baden-Württemberg

micro-biolytics GmbH With the AquaSpecTM Technology, micro-biolytics Schelztorstr. 54-56 offers a new class of analytical technology within D-73728 Esslingen liquid solutions. This innovating technology is Phone: +49 (0) 711/90 12 11 0 based on middle infrared spectroscopy which is Telefax: +49 (0) 711/90 12 11 90 0 recognized as the most sensitive optical absorp- process knowledge is essential. The AquaSpecTM [email protected] tion technique for detecting all molecular details Technology can give a detailed insight in the com- www.micro-biolytics.com in lowly concentrated organic compounds (e.g. position of the culture broth. Enabling the simul- compared to NIR or UV/VIS). The AquaSpecTM taneous detection of many relevant substances such Contact person: Technology platform provides fast and powerful as substrates, products or side products even in low Andreas Wolf tools to detect the state as well as changes of an concentrations within a two minutes measurement. observed solution. By means of the fully auto- Employees: 9 mated MIRA – Analyzer Series the AquaSpecTM Diagnostics – determine diseases Technology offers a wide range of applications in by specific patterns Production range/Services: pharmaceutical, clinical and other analytical fields. Some diseases generate specific changes in the • Pharmaceutics metabolic pattern of blood or other body fluids • drug screening, formulation and Applications: Pharmaceutics – stability studies and can be identified and classified by their charac - stability studies By AquaSpecTM Technology, aqueous as well as teristic spectroscopic markers using AquaSpecTM • Proteomics – identify and organic solutions can be investigated in the range Technology. Our partner Cetics Healthcare Tech- characterize proteins of minutes without sample pre-treatment, yielding nologies ensures a drastic simplification of ana- • Process Analytical Technology detailed information about the current state of lyses in toxicology, cell culture quality control, and manufacturing QC – the measured sample. Thus, in many applications pharmaceutical development. Cost-effective high- optimize processes AquaSpecTM Technology is an additional option or precision infrared spectra can be obtained from • Diagnostics – determine diseases alternative to HPLC and GC. biological samples such as blood serum, liquor, by specific patterns and cell culture supernatants with the patented • Service measurements Process Analytical Technology AquaSpecTM MIR spectroscopy method. Complex • Feasibility studies and manufacturing QC – optimize processes information about the individual composition of In Process Analytical Technology, the main challen ge every sample becomes available in digital form. Fields of action: is to find out properties and compositions of rele - • Agriculture/Food vant substances with highest quality demands. micro- Food & quality analysis with Q • Food • Analytics biolytics develops individual AquaSpecTM Process The Q • FOOD analysis system, a compact very • Biotechnological Services Analytical Technology solutions and provides overall precise system for liquids such as beer and soft • Supplier customer support. AquaSpecTM MIRA Analyzers can drinks. The analysis method gives you the possi- be implemented for both laboratory and process bility to measure the most important ingredients environment (atline/online) and are in line with at once, e.g. bitterness, alcohol, sugar, or the pH the FDA Process Analytical Technology initiative. value. The result is already available a few minutes One of the main aims in fermentation/cell culture after the measurement, without involving an is to improve the space-time yield and reduce time external laboratory. Secure the quality of the pro- for process development. But therefore detailed ducts themselves - right on the production line.

102 The Biotech Company MicroMol was founded in MicroMol GmbH 1997 by the microbiologists Dr. Andrea and Hedwigstr. 2-8 Dr. Andreas Dreusch and is still a private and D-76199 Karlsruhe independent enterprise with an innovative Phone: +49 (0) 721/94 15 213 concept combining highly qualified technical Telefax: +49 (0) 721/94 15 214 expertise with competence in Food Quality [email protected] • [email protected] Management. MicroMol engages at the moment www.micromol.com • www.fpqs.de 30 skilled scientific employees working in different fields of activity divided into research, consulting Contact person: Dr. Wolfgang Rudy and service/contract research. MicroMol’s strength models. Moreover – based on its specific pathogen Employees: 30 lies in the power to flexibly implement and mana- free origin - this system represents a powerful new ge customer directed R&D tasks in the fields of platform for recombinant expression in eukaryotic Production range/Services: • Implementation of Western blotting Microbiology, Molecular Biology/Biochemistry cells. Last but not least MicroMol is able to imple- and ELISA applications and Tissue Culture/Immunology. For this purpose ment specialized customer orientated demands, • Epitope determination/scanning of MicroMol offers a perfectly equipped Research including PCR strategies, cloning and expression proteins and antibodies Laboratory with about 400 square meters lab of recombinant proteins and detection strategies • Generation and evaluation of space located in the south of Karlsruhe. in a reasonable time frame. specific antisera • Advanced Microbiology • Microbiological analysis To provide deeper insight into its project portfolio In addition to that MicroMol’s food branch (Food of food samples MicroMol finds itself as one of the rare specialists Production Quality Service; http://www.fpqs.de) • Implementation of PCR strategies for the detection an determination of bacterio- provides sophisticated consulting strategies for food • Cloning on demand phages in cell banks an expression cultures. In the producers according to international guidelines, • Generation, expression and purification of recombinant proteins in field of sophisticated functional testing models among them the ISO 22000:2005, IFS and BRC. prokaryotic and eukaryotic systems MicroMol has set up a platform for the alternative In this regard MicroMol offers a special laboratory • Advanced tissue culture applications evaluation of chemicals, substances and cosmetics platform for the evaluation of food samples, the • Detection and determination according to their cytotoxicity as well as to their determination of microorganisms and microbial of bacteriophages • Determination of cytotoxicity, skin corrosive and irritative potential to the skin (DIN/ contamination in nutrition, fermenter cultures and corrosion and irritation according to ISO 10993-5; OECD 431). The field of complex other substrates as well as the determination of DIN/ISO 10993-5 and OECD 431 testing is complemented by the generation of a food allergens with immunological test systems. • Development of functional cell panel of proprietary chicken enterocyte cell lines culture models serving for the establishment of in vitro pathogen MicroMols Lab Services are accredited Fields of action: infection- as well as complex gut penetration according to the standard ISO 17025:2005 • Agriculture/Food • Analytics • Biotechnological Services • Cells/Cell Lines • Custom Production • Production Organisms • Proteins/Peptides

103 BIOPRO Baden-Württemberg

Multi Channel Systems The success of the medium-sized business MCS GmbH Multi Channel Systems is based on its con- Aspenhaustr. 21 stantly growing highly-specialized work force. D-72770 Reutlingen The majority of the creative team holds a Phone: +49 (0) 7121/90 92 50 PhD in physics, biology, electronics, computer Telefax: +49 (0) 7121/90 92 511 sciences or engineering. The wide variety of [email protected] experiences is incorporated in the develop- www.multichannelsystems.com ment of innovative high-tech products. applications. Our team has research experience and knows the daily work in laboratories and Contact person: Karl-Heinz Boven Multi Channel Systems MCS GmbH was foun- its problems. Thus, we can develop products ded in 1996 and is based in the Science and researchers really need. Branches: Technology Park in Reutlingen in Southwest 10 distribution partners worldwide Germany, from where it operates globally. Furthermore, we are in permanent dialog with The main focus of our company is the devel- scientists and strive to be at the cutting edge Employees: 45 opment of precision scientific measuring of technology. This opens up our high innova- instrumentation and equipment in the field of tion potential. Additionally, we are constantly Production range/Services: electrophysiology for research groups at uni- involved in several national and international • Recording systems for in vitro versities and for the pharmaceutical industry. projects pushing the limits and developing and in vivo electrophysiology: Because of their modular principle, our pro- innovations constantly. Complete multi-channel systems ducts can be extended and adjusted to specific for extracellular recording for experimental needs. All this, as well as over 15 years of experience neuronal and cardiac applications and over 700 satisfied MEA-System users • Automated injection and scree- Our goal is the consequential implementation world-wide make us the global market leader ning devices for Xenopus oocytes of customer-oriented and innovative technolo- in the field of non-clinical microelectrode array • Stimulus generators for current gies. The development according to customers’ electrophysiology. In doing so we are assisted and voltage stimulation needs means development near to the specific by 10 distribution partners worldwide. • Data acquisition systems, ampli - fiers, and microelectrode arrays • Software for data acquisition, analysis, and stimulation

Fields of action: • Analytics • Bioinformatics • Custom Production • Supplier

104 nadicom Gesellschaft für angewandte nadicom Gesellschaft für

Mikrobiologie mbH angewandte Mikrobiologie mbH Hertzstr. 16 nadicom is a leading international operating D-76187 Karlsruhe GMP-certified biotech company specialising in Phone: +49 (0) 721/60 84 44 81 the identification and characterisation of bacte- Telefax: +49 (0) 721/60 84 46 18 ria and fungi in pure cultures, environmental [email protected] samples and complex mixed cultures. www.nadicom.com

tify micro-organisms, nadicom’s exclusive data- Contact persons: base “tree by nadicom” containing more than Dr. Bernhard Nüßlein (CEO), 45,000 validated entries, is applied. Anja Dolderer (PR)

For the root-cause analyses of microbial conta- Branches: minants we offer genotyping. In this sector we Karlsruhe and Marburg (Germany) have established various validated methods of DNA-fingerprints for bacterial and fungal strains. Employees: 8 Our company is active for the pharmaceutical, food, cosmetics, chemical and agricultural nadicom’s knowledge database “fybase by Production range/Services: industry as well as in building analyses. nadicom” has been created to offer our clients • GMP-compliant identification a fast and comprehensive description of the of microbial isolates (bacteria, For the identification of micro-organisms, the results obtained in laboratory services. Our fungi, yeasts) most modern molecular-biological methods are growing database gives a broad overview about • Molecular-biological identifica- applied. Qualitative identification of bacteria, the prevalent micro-organisms (more than 500 tion of moulds and dust samples fungi and yeast from pure cultures is carried species) present in the pharmaceutical labora- • DNA fingerprinting out via PCR-based methods. To exactly iden- tory including detailed description, classifica- • Education and consultation tion, risk evaluation and literature. • Genotyping

Contracted research represents another focus Fields of action: of the range of services offered. Here, nadicom • Analytics currently works with partners in environmental • Bioinformatics microbiology. The main focus is here on the • Biotechnological Services stimulation of plant-microbe interactions. • Contract Research • DNA/RNA Our services are completed with educational • Environmental Biotech seminars for laboratory personnel in industry and secondary education and consultation in the field of microbiology and environmental monitoring.

105 BIOPRO Baden-Württemberg

nanoTools Antikörpertechnik NanoTools Antikörpertechnik is a science dri- Because of our vast experience in protein che- GmbH & Co. KG ven, product and customer oriented company mistry and antibody design, we are particularly Tscheulinstr. 21 providing monoclonal and polyclonal antibo- well-qualified for the development of antibodies D-79331 Teningen dy development services and products. The directed to ”difficult epitopes“ such as highly Phone: +49 (0) 7641/45 56 70 company was founded in 1994 and is privately conserved proteins, neoepitopes, haptens and Telefax: +49 (0) 7641/45 56 71 owned. It currently occupies close to 1,000 phosphorylated epitopes. Small and large scale [email protected] square meters laboratory facility in Teningen antibody production is performed by serum-free www.nanotools.de near Freiburg. cell culture techniques.

Contact person: Besides providing individually tailored Antibodies are purified by non-denaturing Dr. Petra Schüssler custom solutions, the company develops, chromatographic methods and either deliver- manufactures and markets phosphorylation ed in liquid form or lyophilized according to Employees: 17 and modification-state specific monoclonal our customer’s specifications. Antibodies may antibodies and other innovative reagents for be labelled with Biotin, fluorescent dyes or Production range/Services: signal transduction and Alzheimer research, enzymes on request. • Monoclonal antibodies for high-throughput screening (HTS) and prote- autophagy omics. Innovative Products for Cell Biology and • Cell biology Signal Transduction Research • Oncology Custom Antibody Development and With regard to our own products, nanoTools • Signal transduction Production Antikörpertechnik develops new innovative • Alzheimer research nanoTools Antikörpertechnik offers specialized tools for signal transduction research and related services for the development of antigens and fields. One important example is the develop- Fields of action: mono- and polyclonal antibodies. We focus on ment of ”phosphorylation site“ – specific anti- • Supplier providing individual solutions that are specifi- bodies that distinguish between the activated • Proteins/Peptides cally tailored to optimally suit our customer‘s (phosphorylated) and nonactivated forms of needs. signalling molecules.

106 The company npi electronic GmbH develops npi electronic GmbH and produces measurement equipment for Hauptstr. 96 use in the life sciences (physiological and D-71732 Tamm pharmacological basic research). Phone: +49 (0) 7141/9 73 02 30 Telefax: +49 (0) 7141/9 73 02 40 The company npi electronic GmbH was [email protected] founded in 1989. Based on developments of www.npielectronic.com Hans Reiner Polder during his diploma thesis in 1984, existing intracellular measurement Contact persons: procedures could be improved enormously. Dr. Martin Weskamp By the years, a complete appliance portfolio for the registration of bioelectrical signals was Employees: 10 developed, expanded by systems for substance nics and control theory and make them available applications, micromanipulators, recording for researchers in life sciences. One of the most Production range/Services: chambers and supported by a software for ambitious recent projects was the development Voltage clamp amplifiers, patch data acquisition and experiment control. of the ScreeningTool for high-quality automated clamp amplifiers, bridge amplifiers, drug screening using Xenopus oocytes. extracellular amplifiers, micromani- Today the product and service offer includes pulators, perfusion systems, ionto- development of new measurement processes, npi electronic GmbH is also an industry phoresis systems, drug application custom specific equipping of laboratories as well partner in the CMPB in Göttingen, and of systems, chambers, temperature as training of the employees. Instruments from the Bernstein Center for Computational controllers, data acquisition sys- npi electronic GmbH combine modern electro- Neuroscience in Munich. tems, stimulus isolators

Fields of action: • Custom Production • Supplier

107 BIOPRO Baden-Württemberg

n-bio GmbH Max-Stromeyer-Str. 116 D-78467 Konstanz Phone: +49 (0) 7531/45 71 89 0 Telefax: +49 (0) 7531/45 71 89 90 [email protected] www.n-bio.de

Contact person: Michael Schuster Efficient solutions for a clean environment and communal customers alike. From prelimi- Production range/Services: Our company n-bio is your competent part- nary designs or feasibility studies for project • Biogas from organic waste ner for the production of biogas from organic developers all the way to execution planning • Feasibility studies waste and renewable crops. Our staff has more and construction supervision – the engineering • Planning of biogas plants than 10 years of experience in designing, buil- experience of n-bio is your key to success in • Project management ding and operating biogas plants. bioenergy. We have an impressive record of • Biogas for agriculture successfully completed international projects in • Microbiology Extensive knowledge of both plant engineering the UK, Scandinavia, Austria and the Baltics. and microbiology enables us to build tailor- Fields of action: made high quality biogas plants in accordance If you are looking for a competent engineering • Environmental Biotech with industrial standards. Our company spe- partner for international projects, do not hesi- cializes in the anaerobic digestion of organic tate to contact n-bio at our offices in Constance. waste such as supermarket waste, kitchen waste and waste from the food industry.

n-bio is a subsidiary company of FARMATIC Anlagenbau GmbH combining our excellence in process engineering with 50 years of bolted steel tank construction and the design of highly efficient vertically stirred tall digesters. Vertically stirred tall digesters based on the CSTR principle are superior to conventional AD systems because of their higher energy efficiency and better intermixing of the substrate. They require very little maintenance and can be erected worldwide with consistent quality.

n-bio designs, builds and commissions complex biogas projects for agricultural, industrial

108 Oncotest is a CRO specialised on preclinical and cost-efficient screening using these suspensions. Oncotest GmbH efficacy profiling of novel anti-cancer molecules. Am Flughafen 12-14 Promising indications and potential biomarkers Once suitable tumor models are identified by the D-79108 Freiburg are identified using a combination of in vitro in vitro and ex vivo screenings, as well as pharmaco- Phone: +49 (0) 761/5 15 59 14 and in vivo studies with Oncotest‘s extensively logical and molecular characterization, drugs can Telefax: +49 (0) 761/5 15 59 55 characterized collection of more than 350 unique be profiled in vivo. Since Oncotest’s patient-derived [email protected] patient-derived tumor xenografts (PDX) growing xenografts (PDX) are transplanted and passaged as www.oncotest.de in nude mice. Oncotest has an industry-leading solid tumor fragments and not cell lines, they retain experience, gained by pioneering the rapidly grow- relevant characteristics of the donor material such as Contact person: ing xenograft field, and a more than 20-year track tumor architecture, molecular and protein altera - Prof. Dr. H. H. Fiebig, CEO record since then. The company is exclusively tions. This contributes to making these models high - focused on oncology and has a highly committed ly predictive with respect to the patient situation. Employees: 80 and expert team, supporting its customers throughout tailoring and execution of their studies. Biomarker hypothesis can be derived by correlating Production range/Services: pharmacological data from Oncotest’s assays with Oncotest offers in vitro and in vivo Oncotest offers a sophisticated system for step- molecular characteristics. Oncotest’s tumor model screens on permanent tumor cell wise screening of compounds and tumor types: collection is sufficiently large to enable early bio- lines (monolayer assay) or patient- The monolayer assay is a 2D high throughput marker identification for novel compounds, already derived xenografts (clonogenic screen for a broad range of compounds based on in a preclinical setting with a meaningful study size. assay and in vivo studies), early bio- a cell proliferation assay, supporting late discove- marker identification, and mecha- ry/ early development. Oncotest provides more Since all Oncotest assays are based on proprietary nism of action studies in Oncology than 200 cell lines, 60 of which are proprietary. PDX models, customers are enabled to use the same models for all studies in a stepwise and stre- Fields of action: For the tumor clonogenic assay (TCA) more than amlined approach towards clinical trials. Oncotest’s • Analytics 300 PDX models can be resected directly from competence in assay system integration guarantees • Biotechnological Services mice and prepared as cell suspensions to provide efficient testing with accurate and relevant results, • Cells/Cell Lines a useful tool for guiding in vivo studies. Oncotest’s ultimately reducing the attrition rates in clinical tri- • Contract Research new 96 well clonogenic assay allows for very fast als and bringing better drugs to the market faster. • DNA/RNA • Proteins/Peptides Oncotest tumor histotypes ^ƚĞƉǁŝƐĞĞǀĂůƵĂƟŽŶ Skin Head/ Neck • Therapeutics

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ŝŽŵĂƌŬĞƌ/ĚĞŶƟĮĐĂƟŽŶ

Histology, Protein Services

109 BIOPRO Baden-Württemberg

PANATecs GmbH PANATecs is a service provider for protein Inselwiesenstr. 10 analysis and a manufacturer of diagnostic D-74076 Heilbronn products. PANATecs has been awarded the Phone: +49 (0) 7131/79 70 40 ISO 9001 Certificate. The company possesses Telefax: +49 (0) 7131/79 70 42 99 manufacturing authorization for test labo- [email protected] ratories in accordance with §13 of the 15th www.panatecs.com Amendment of the Medicines Act.

Contact person: For almost 10 years, PANATecs has been per- Dr. Thomas Frischmuth (CEO) forming essential work for the pharmaceutical, diagnostic testing and biotechnology indus- Employees: 20 tries. With its team of highly qualified scientists and technicians – all with experience of Production range/Services: industry - PANATecs supports technological • CMC (chemistry manufacturing progress in the Life Sciences industry. and controls) and protein characterization PANATecs Services: LIFE SCIENCE TOOLS: • R&D analyses and peptide CMC AND PROTEIN CHARACTERIZATION: PANATecs is an established developer of synthesis PANATecs offers analytical characterization innovative life science tools for use in protein • Life Science Tools for use in of proteins and antibodies, as well as method analysis, immunology and cell biology. The protein analysis, immunology and development and analyses for GMP release. products are used as instruments for scree- cell biology Much of PANATecs‘ work deals with mass ning T-cell immune reactions and for control- spectrometric studies of active substances. ling protein production. Fields of action: • Analytics R&D ANALYSES AND PEPTIDE SYNTHESIS: • Biotechnological Services The routine mass spectrometric analyses, • Custom Production N-terminal sequencing and quantitative • Proteins/Peptides amino acid analyses make PANATecs the ideal • Supplier partner for resolving problems in early R&D. PANATecs synthesizes customer-specific peptides in their own peptide synthesis laboratory. The company specializes in unusually long or complex proteins, obviously with reliable quality control.

110 PEPperPRINT GmbH Rischerstr. 12 D-69123 Heidelberg Phone: +49 (0) 6221/72 64 488 Telefax: +49 (0) 6221/72 64 475 [email protected] www.pepperprint.com

Contact person: Dr. Volker Stadler

PEPperPRINT is a young and innovative bio- power or technical infrastructure. They include Production range/Services: tech company based in Heidelberg and a spin- microarray design and synthesis as well as immu- • PEPperCHIP® Peptide Microarrays off of the German Cancer Research Center. The noassays, read-out, data evaluation and reporting. for clinical & biomedical research company provides the new peptide microarray (epitope mapping, serum antibo- platform PEPperCHIP® for immunological PEPperPRINT’s portfolio is complemented by dy profiling, kinase substrate research, biomarker discovery and peptide drug PEPperSlides® NHS Glass Slides, which are the screening...) development. Due to its proprietary and award- ideal substrate for covalent immobilization of • PEPperMAP® comprehensive pep- winning peptide laser printing technology, the proteins such as antibodies, antibody fragments, tide microarray analysis service high-content PEPperCHIP® microarrays set enzymes or receptors. PEPperSlides® NHS Glass • PEPperSlides® NHS Glass Slides a new standard in terms of peptide diversity, Slides are based on a sophisticated 3D polymer for protein immobilization signal quality and content flexibility. coating that blocks non-specific protein interaction 100times better than BSA. Fields of action: The PEPperCHIP® platform is predominantly • Analytics applied for antibody characterization by epitope • Biotech Services mapping and epitope permutation scans. PEPper- • Custom Production CHIP® microarrays further allow the profiling of • Diagnostics antibody immune responses in blood sera linked • Proteins/Peptides with infection, immunization, autoimmune disea - • Therapeutics ses or cancer. Besides antibody analysis, PEPper- CHIP® microarrays are a perfect tool for kinase substrate profiling and the incorporation of unna- tural amino acids makes PEPperCHIP® microarrays also suitable for peptide drug optimization.

The PEPperMAP® services enable to benefit from PEPperPRINT’s new peptide microarray platform PEPperCHIP® without any need for time, man-

111 BIOPRO Baden-Württemberg

Peptide Specialty Peptide Specialty Laboratories (PSL) GmbH Laboratories GmbH was founded in August 2000 as a spin-off com- Im Neuenheimer Feld 583 pany of the German Cancer Research Center D-69120 Heidelberg (DKFZ) in Heidelberg, Germany. The com- Phone: +49 (0) 6221/88 96 12 pany is located within the Technology Park Telefax: +49 (0) 6221/88 96 13 Heidelberg in direct neighborhood of univer- [email protected] sity institutes, university hospitals and other www.peptid.de biotech companies.

Contact person: The major goals of the PSL GmbH are the Dr. H.-R. Rackwitz production and marketing of peptides, peptide of peptides with chain lengths of 50 or more analogues, bioconjugates and peptide speci- amino acids. Employees: 7 fic antisera. Dr. Hans-Richard Rackwitz, one of the cofounders and manager of the PSL Furthermore, services of PSL GmbH include Production range/Services: GmbH, has many years of experience in the the purification of the peptides by HPLC as • Peptides field of peptide synthesis and antibody pro- well as HPLC analysis and MALDI-TOF mass • Bioconjugates duction, which is well documented in a large spectrometry for synthesis and purity con- • Polyclonal antibodies in guinea number of publications. trol. Our main customers are found within pigs and rabbits the industry and the research community of The instrumentation of PSL GmbH allows the Germany and the European Community but Fields of action: simultaneous syntheses of up to 144 peptides we also serve any customer around the world. • Custom Production with a chain length of up to 30 amino acids. • Proteins/Peptides Highly optimized synthesizers are set up to Information about our products and prices are • Supplier yield peptide amounts of up to one gram. available in the internet under These synthesizers also enable the syntheses http://www.peptid.de.

112 For more than 20 years PromoCell has been PromoCell GmbH a reliable supplier of biomedical products Sickingenstr. 63/65 to research and industry. We are an ethically D-69126 Heidelberg responsible partner in all areas of cell culture Phone: +49 (0) 6221/64 93 4 0 research and associated specialist fields. Due to Telefax: +49 (0) 6221/64 93 4 40 the quality of our product range and the relia- [email protected] bility of our advice and service, we are now the www.promocell.com leading European manufacturer in the field of www.promokine.info primary human cell culture. Serum- and prote- www.promocell-academy.com in-free PromoCell media open up new opportunities in the areas of tissue engineering, Our Sales Philosophy Contact person: protein expression and process standardisation PromoCell has specialists in your field. You can Dr. Irma Börcsök within cell culture. With the PromoKine be offered skilled advice on choosing and ap- product line, we provide a wide range of cell plying the correct PromoCell product. In addi- Employees: 55 biology tools. tion this knowledge will be delivered to you in your own native language. For this purpose and Production range/Services: Customers are invited both to consult our for your convenience we have established the • Normal human cells from advisory service and to visit our PromoCell Cell Line (free phone line) in France, Germany, different locations, e.g. skin, Academy, to take full advantage of our exten- the United Kingdom and the United States of bloodvessels, fat tissue, bones sive expertise. It will be rewarding for us to America. • Stem and blood cells know that we have contributed to your • Cell-type specific media, success. We Welcome Your Requests and low serum, serum-free Suggestions • Cell Biology Tools: PromoCell is active globally, with own sales Our current programme is the result of your Transfection representatives and a distribution network wishes and suggestions. PromoCell is com- Cell analysis kits spread across many countries. mitted to providing its customers, at all times, Cytokines and ELISAS with appropriate and innovative solutions to • Classical media their queries, in the form of both products • Buffers; bio-reagents and technical support. Your satisfaction with PromoCell products will be guaranteed Fields of action: through a dynamic interaction with ourselves. • Cells/Cell Lines Contact PromoCell. We are here to help you. • Supplier

113 BIOPRO Baden-Württemberg

ProQinase GmbH Company Focus and Future Perspective Breisacher Str. 117 ProQinase is a leading biology contract service D-79106 Freiburg provider (CRO) dedicated to support pharmaceu- Phone: +49 (0) 761/2 06 17 80 tical and biotech companies in the development Telefax: +49 (0) 761/2 06 17 81 of novel therapies for cancer treatment. The com- [email protected] pany has a long-lasting scientific experience in the www.proqinase.com fields of tumour angiogenesis and protein kinase research as proven by its contribution to two suc- Contact person: cessful development projects in cancer going from Dr. Christoph Schächtele scratch to clinical trials in Phase I and Phase III.

Employees: 37 Products & Services • Angiogenesis assays: cellular assay and ProQinase has established a comprehensive in vivo model based on spheroids from Production range/Services: Cancer Drug Discovery Platform which com- human endothelial cells • Recombinant protein prises the following products and services: Moreover ProQinase enables rapid access to kinases & substrates • More than 280 recombinant protein kinases clinical trials due to its affiliation with the • Biochemical assay services: • Screening services with more than 380 Tumor Biology Center Freiburg, Germany.

HTS, IC50-profiling protein kinases (HTS, IC50 and large scale • Cellular assay services profiling) with rapid turnover in high Business and Deals • In vivo testing services speed robotic systems Most of the largest pharma companies are • Angiogenesis assay services • Cellular assays, target-specific and pheno- among our customers. typic assays, e.g. proliferation and colony We are offering Fields of action: formation assays • Frame work contracts for the service • Analytics • In vivo models, subcutaneous and orthoto- business • Biotechnological Services pic test systems • Standard discounts • Cells/Cell Lines • Attractive conditions • Custom Production • Proteins/Peptides Background • Therapeutics ProQinase was founded 2001 as a subsidiary of the Tumor Biology Center Freiburg, one of the largest privately owned hospitals of this type in Europe, to market the broad know-how about protein kinases. Our team of internationally trained scientists owns more than 20 years of scientific expertise in protein kinase and signal transduction research, coming both from the industrial and academic area.

114 Knowledge-based custom speciﬁc products Q-bios GmbH and consultance for the life sciences Paul-Wittsack-Str. 10 Q-bios GmbH, founded in 2009, is a spin- D-68163 Mannheim off from the Institute for Molecular and Cell Phone: +49 (0) 621/29 26 53 7 Biology, Department of Biotechnology, at the Telefax: +49 (0) 621/43 95 53 2 Mannheim University of Applied Sciences. [email protected] Q-bios provides services for the life sciences www.q-bios.com in general and the biotechnology and pharmaceutical industry in particular. The success Contact person: of Q-bios is based on broad knowledge and Dr. rer. nat. Andreas Lux long-time experience of the two company‘s founders in microbiology, molecular and cell Employees: 3 biology, genetics, medical genetics and protein analytics. This allows for customer-specific Production range/Services: solutions. • Recombinant proteins • Antigens Q-bios provides services in bulk or retail Taq. Q-bios has started to specialise on the • Taq polymerase recombinant protein production using bacte- manufacturing of client-specific PCR Master • PCR Master Mixes rial, insect cell and eukaryotic cell expression Mixes for real-time PCR and diagnostic pur- • Assay development systems, as well as molecular and cell biology poses. Furthermore, all of our PCR related • Training assay development and production. All custo- products and PCR Master Mixes are offered in mers profit from our project specific counsel- a lyophylised form. Fields of action: ling service. Products can be purchased directly • Biotechnological Services from us or are marketed by a distributor. Many • Cells/Cell Lines of our products are intermediates and are used • Custom Production by nationally and internationally acting dia- • Diagnostics gnostica companies. • DNA/RNA • Production Organisms One of Q-bios’ major products is the produc- • Proteins/Peptides tion and client-specific formulation of the • Supplier thermostable DNA polymerase from Thermus aquaticus (Taq). We offer Taq polymerases with variable activity concentrations (1 U/μl - 60 U/ μl) formulated, for example, as a HotStart-Taq suited for real-time PCR or as Taq in glycerol free storage buffer. In addition, we provide Taq polymerases of different purity grades ranging from regular preparation grade to DNA-free

115 BIOPRO Baden-Württemberg

ravo Diagnostika GmbH ravo Diagnostika was founded in 1995 by Oltmannsstr. 5 Prof. Dr. med. Arnold Vogt, former director of D-79100 Freiburg the Department of Immunology of the Institute Phone: +49 (0) 761/40 74 88 of Medical Microbiology and Hygiene, Albert- Telefax: +49 (0) 761/40 74 77 Ludwigs-University in Freiburg, Germany, and [email protected] two of his co-workers, Dr. rer. nat. Christiane www.ravo.de Rasiah and Dr. med. Sebastian Rauer. Contact person: Dr. Christiane Rasiah We focus our activities to development and production of immunoassays for the diagnosis of Employees: 11 infectious and autoimmune diseases and we set a high value on good quality and support. Production range/Services: • Indirect hemagglutination assays Our customers are medical laboratories all over for the diagnosis of: the world. The product range comprises indirect Aspergillus fumigatus, Candida haemagglutination assays, enzyme-linked immu- albicans, Borrelia burgdorferi, nosorbent assays, immunefixation assays and Helicobacter pylori and immunoblots. Leptospira • ELISA’s for the diagnosis of We introduced a Quality System according to infections with Candida albi- EN ISO 9001 and EN ISO 13485 and according cans, Borrelia burgdorferi and to the Council Directive 98/79/EC, Annex Helicobacter pylori. IV- Section 3. • Line Assays (Immunoblots) for the detection/diagnosis of: - Paraneoplastic autoantibodies anti- HuD, anti-Yo, anti-Ri, anti-Amphi- physin, anti-CV2 (CRMP5), anti- Ma1, anti-Ma2 (Ta) and anti-SOX1. - Autoantibodies anti-GAD65 - Autoantibodies anti-MAG - Lyme disease • ISAGA’s and DIFA for the diagnosis of Toxoplasmosis

Fields of action: • Diagnostics

116 We offer: rent-a-lab Dr. Carsten Tober • [125I]-iodination service Aspenhaustr. 25 for peptides, antibodies, DNA etc. with D-72770 Reutlingen common methods (chloramine T, lacto- Phone: +49 (0) 7121/51 53 67 0 peroxidase etc.) Telefax: +49 (0) 7121/51 53 67 9 • receptor binding assays [email protected] classical receptor saturation, homologous www.rent-a-lab.biz displacement, heterologous displacement with [3H]- [14C]- and [125I]-labelled ligands Contact person: • in vivo receptor occupancy studies Dr. Carsten Tober after application of test compounds in rat and mice Employees: 3

A 96-well harvester for microplate assays … Production range/Services: • Custom labelling service • pharmacology of GPCRs with [125I] by [35S]GTPgS binding tests (functional) to • Enzyme assays investigate G protein activation (also • Transmitter reuptake available: Ga-subtyp-specific assays) • Receptor binding assays • GPCR pharmacology Services are customized to meet specific needs • RIAs reaching from individual small scale solutions • In vivo – receptor occupancy to microplate solutions for medium-through- assays put screening (MTS). • Receptor mutagenesis studies

Fields of action: • Analytics • Biotechnological Services rent-a-lab operates a modern radionuclide laboratory • Contract Research

• enzyme assays with radioactive or absorption read-outs • transmitter reuptake into rat synaptosomes (presynapses) • RIAs with [3H]- and [125I]-labelled tracers to quantify target molecules in serum/plasma or tissue extracts ... enabling e.g. [35S]-GTPƣS-screens

117 BIOPRO Baden-Württemberg

Rentschler Biotechnologie GmbH Rentschler Biotechnologie GmbH is an inter- Erwin-Rentschler-Str. 21 national full-service contract manufacturer D-88471 Laupheim with a highly skilled staff of 650 and has more Phone: +49 (0) 7392/70 15 55 than 35 years of experience in the develop- Telefax: +49 (0) 7392/70 14 00 ment, production and approval of biophar- [email protected] maceuticals in compliance with international www.rentschler.de GMP standards. Regulatory advice and fill and finish are part of the company‘s service Contact person: range. As a pioneer in the development and Dr. Alexander Götz production of biopharmaceuticals, Rentschler was the first company in the world to gain Branches: 1 (USA) market authorization for an interferon-contai- success of any project – rapidly and reliably. ning drug. Dedicated to deliver high-quality Rentschler is flexible when it comes to ser- Employees: 650 biopharmaceuticals produced in mammalian vices, capacity and products – for process cell culture, Rentschler has nine stand-alone development or production of materials for Production range/Services: GMP suites with volumes of 30, 50, 100, 250, clinical trials and the market, whether low- Advanced Services: 500, 1,000 and 2,500 liters, allowing the pro- dose cytokines or high-dose antibodies and • Corporate project management duction of material for clinical trials and for biosimilars. • Cell line development supplying the market. • Bioprocess development Rentschler Biotechnologie is a responsible • Production of active Rentschler provides customized, integrated and experienced partner to implement pro- pharmaceutical ingredients (API) biopharmaceutical services, from cell line to ject goals, coordinate operations and com- • Formulation, fill and finish the development and production of the active municate progress updates to its customers. • Quality control ingredient and from marketing authorization Combined with Rentschler’s experience in • Regulatory affairs to fill and finish. The long-term experience of international regulatory affairs and authori- • Quality assurance Rentschler Biotechnologie combined with the ties, this speeds up the time to market and range of comprehensive services ensures the ensures the market success.

Fields of action: • Analytics • Biotechnological Services • Cells/Cell Lines • Custom Production • Production Organisms • Proteins/Peptides • Therapeutics

118 RHEACELL GmbH & Co. KG Im Neuenheimer Feld 517 D-69120 Heidelberg Phone: +49 (0) 6221/71 833 0 Telefax: +49 (0) 6221/71 833 29 [email protected] www.rheacell.com

Contact person: Dr Christoph Ganss, MD Professor Dr Markus Frank, MD

Branches: A Joint Venture between a strong partner Offices and laboratory at and TICEBA technology park Heidelberg

Founded in 2012 RHEACELL is dedicated to the Production range/Services: development of human pharmaceuticals based on • Drug development based ABCB5 positive mesenchymal skin stem cells. For on stem cells selected indications RHEACELL strives for the improvement of quality of life as well as abate- Fields of action: ment and healing of ailments of patients. • Cells/Cell Lines • Custom Production RHEACELL is obligated to meet the requi- As a licensee of a number of patents of • Supplier rements of the European law throughout Harvard University, Cambridge/USA, the whole development process of stem cell- RHEACELL has worldwide exclusive rights to based pharmaceuticals. Similarly, latest inter- this technology. RHEACELL can make use of national findings of science and technology as this technology when developing pharmaceu- well as in-house know-how of RHEACELL’s ticals. Professor Dr Markus Frank, MD is assi- qualified staff play a key role in realizing sting RHEACELL as scientific advisor. He has the mission. The requirements of Good particular expertise in stem cell research. Manufacturing Practice will be met throughout the entire process.

119 BIOPRO Baden-Württemberg

Roche Diagnostics GmbH Roche Diagnostics As one of the hubs of the Group’s diagnostics Roche Diagnostics business, Roche Mannheim plays a central role. Deutschland GmbH Headquartered in Basel, Switzerland, Roche The Rhine-Neckar Metropolitan Region with Sandhofer Str. 116 is a leader in research-focused healthcare its biotech clusters provides the company with D-68305 Mannheim with combined strengths in pharmaceuticals an excellent research and development envi- Phone: +49 (0) 621/75 90 and diagnostics. Roche is the world’s largest ronment. Roche Mannheim is the third largest [email protected] biotech company with truly differentiated site in the Roche Group and one of the most www.roche.de medicines in oncology, virology, inflamma- diverse. It is a major operational hub for the tion, metabolism and CNS. Roche is also the Group’s Diagnostics Division and headquarters Contact person: world leader in in-vitro diagnostics, tissue- of the division’s Diabetes Care unit. Activities at Dr. Monika Mölders based cancer diagnostics and a pioneer in the site include research and development, pro- diabetes management. Roche’s personalized duction, strategic marketing and global logistics Fields of action: healthcare strategy aims at providing medi- for the Diagnostics Division and production • Analytics cines and diagnostic tools that enable tangible and packaging of finished biopharmaceuticals • Diagnostics improvements in the health, quality of life for Roche’s Pharmaceuticals Division. More than • DNA/RNA and survival of patients. 7,500 people are employed at the site. • Proteins/Peptides • Therapeutics

120

Sciomics – Antibody meets microarray Sciomics GmbH Schneidmühlstr. 19 Sciomics GmbH was founded in spring 2013 as a D-69115 Heidelberg spin-off company of the German Cancer Research Phone: +49 (0) 6221/32 71 23 3 Center (DKFZ). Since 2003 our team is expe- [email protected] rienced in the production and application of anti- www.sciomics.de body microarrays as a tool for the analysis of complex protein samples. Sciomics offers a complete Contact person: analysis service of your samples with standardised Dr. Christoph Schröder as well as customised arrays. Production range/Services: Analyse your protein sets of interest • Custom antibody microarrays Using antibody microarrays it is possible to analy- analysis service including the protein extraction • Analysis service se complete signalling pathways, up-/downstream from plasma, serum, tissue or cell culture samp- • Proteomic profiling elements of your protein of interest or hits from les, the sample labelling, the incubation as well • Antibody characterisation next generation sequencing. For such an analysis as the subsequent data analysis. • Biomarker discovery and only very small sample volumes such as 15μL are verification needed. This facilitates a robust and multiplex Identiﬁcation of protein biomarker signatures analysis of plasma or tissue proteins not only In addition, antibody microarrays are a valuable Fields of action: from human but also from murine samples. tool for the identification or verification of protein • Analytics biomarkers. Based on complex antibody microar- • Biotechnological Services We offer standardised arrays or produce custo- rays, biomarker signatures were identified for a • Custom Production mised arrays for your list of targets or with your prognosis in bladder cancer and a diagnosis of pan- • Diagnostics selection of antibodies. Based on more than a creatic cancer. Contact us to learn more about the • Proteins/Peptides decade of experience in profiling studies with potential of complex antibody microarrays for your antibody microarrays, we also offer a complete protein biomarker screening or verification study.

Typical results of an antibody microarray profiling study

121 BIOPRO Baden-Württemberg

SEARCH-LC GmbH Bergstr. 140 D-69121 Heidelberg Phone: +49 (0) 6221/41 86 04 Telefax: +49 (0) 6221/41 86 08 [email protected] www.search-lc.com

Production range/Services: Parameter-specific kits for the LightCycler® system of ROCHE Diagnostics Search-LC GmbH was founded within an time. This approach reduces the incidence cooperation between ROCHE Diagnostics of recurrent infections and malignant disease Fields of action: GmbH and the Institute of Immunology of the as well as the degree of the kidney damage • Analytics University of Heidelberg. The company offers in transplanted patients significantly, which • Biotechnological Services currently more than 1,000 parameter-specific greatly improves their long-term outcome. In • DNA/RNA kits for the LightCycler® system of ROCHE the area of chronic-bowel disease Search-LC • Supplier Diagnostics. has identified multiparametric patterns, which measure the degree of inflammation in situ On the diagnostic sector Search-LC GmbH and can be employed to monitor anti-inflam- has developed an assay which measures the matory therapy. individual degree of immunsuppression in patients using Calcineurinin inhibitors, Another activity of the company is the eva- which permitted an individual adaptation of luation of assays to detect micrometastases in the immunsuppressive therapy for the first sentinel lymph nodes.

122 Sensovation is focused on the development Sensovation AG and manufacturing of unique innovative imag- Markthallenstr. 5 ing systems. Sensovation offers intelligent D-78315 Radolfzell optical detection solutions ranging from sci- Phone: +49 (0) 7732/30 27 8 20 entific cameras up to highly integrated instru- Telefax: +49 (0) 7732/30 27 8 39 mentation for multiplexed diagnostics. [email protected] www.sensovation.com Our product line includes a range of cooled, high resolution, high sensitivity scientific Contact person: cameras for low-light imaging applications. Dr. Hanswilly Müller These cameras are used in biotechnology and – with increasing demand – in the photovoltaic Employees: ca. 30 industry for characterization of solar cells and modules. Production range/Services: FLAIR Fluorescent Array Imaging Reader – automated • SamBa - scientific cameras For the field of diagnostics and clinical research microarray reader system for readout and analysis for • CLAIR and FLAIR array Sensovation offers solutions for multiplexed fluorescent microarrays in 96-well plates. imaging readers for diagnostics, which enables simultaneous multiplexed diagnostics detection of several parameters in one sample. the wells of 96-well plates. Other formats, e.g. • Customized microscopy systems Sensovation currently offers microarrays rea- slides can also be accommodated. FLAIR is de- ders in its multiplex series: CLAIR and FLAIR. signed for multiplex-enabled fluorescent read-out. Fields of action: CLAIR is an imaging reader for colorimetric The instruments are astonishingly compact and • Analytics read-out of microarrays on the bottom of affordable and have been designed with routine • Diagnostics applications in mind. Sensovation’s instrument • Supplier concept enables the easy transition of microarray applications from research to clinical routine. Thus Sensovation offers a new dimension in multiplexed imaging for diagnostics, point- of-care and biotechnology.

Sensovation is primarily active in the OEM business and also designs customer specific imaging products. With systems insight, Sensovation works together with diagnostic companies during the assay development process. The result coolSamBa HR-320 scientific cooled camera for is a cost efficient and application-tailored plat- high sensitivity and high resolution imaging in form, with the tools and services needed for biotechnology and diagnostics. successful multiplexed analysis.

123 BIOPRO Baden-Württemberg

SGS M-Scan GmbH SGS M-Scan are the world’s number one bio- Engesserstr. 4a pharmaceutical mass spectrometry & biophysical D-79108 Freiburg characterisation service provider with over 30 Phone: +49 (0) 761/61 16 77 60 years of industry leading, global regulatory pro- Telefax: +49 (0) 761/61 16 77 66 ven experience. At our laboratories in Germany [email protected] (“Biotechpark” Freiburg), Switzerland, the UK and www.sgs.com/m-scan the US we provide GLP/cGMP compliant analyses for biopharmaceuticals, from small molecules/new Contact person: molecular entities and peptides through to pro- Marie-Ann Dhaen teins and glycoproteins, such as monoclonal anti- M-Scan offers a global service and is dedicated to Phone: +49 (0) 761/61 16 77 60 bodies. To date, we have worked on the top 30 guiding and supporting clients from initial drug Dr. Pascale Seiter, Office Bonn biological products that have made it to market, discovery through to full regulatory approval. Phone: +49 (0) 228/85 09 14 5 as well as on many other originator, biosimilar and biobetter products still in development. Production range/Services: Branches: SGS M-Scan is part of Structural, physicochemical and biophysical analysis the SGS Life Sciences Services We have extensive experience of applying our of peptides, (glyco)proteins and antibodies: Amino group. SGS Life Science Services is specialist analytical skill-set at all stages of the Acid Analysis, N- and C-Terminal Sequencing, De the largest network of contract ana- product lifecycle from cell line selection, process Novo Protein Sequencing, Intact Molecular weight, lytical laboratories with 19 facilities verification, pharmacokinetic & metabolism stu- Peptide Mapping, Disulfide Bridge Analysis, in 11 countries. dies through to final product characterisation. PTMs, Protein Aggregation (SEC-MALS, SV-AUC, DLS), Capillary Electrophoresis (cIEF), Liquid Employees: >65 within Analytical packages can be designed to conform Chromatographic Patterns, Spectroscopic Profiles SGS M-Scan Europe to the appropriate FDA/EMA/ICH guidelines (e.g. (CD, DSC, FTIR, NMR), Glycosylation Analysis ICH Q6B for structural and physicochemical cha- (Glycosylation Site, Oligosaccharide Population, Fields of action: racterization). As an experienced, professional, Monosaccharide Composition, Sialic Acid Analysis, • Analytics independent partner in drug development, SGS Linkage Analysis, 2-AB Labeling) etc. • Biotechnological Services • Contract Research • DNA/RNA • Proteins/Peptides • Therapeutics

124 Subitec GmbH Julius-Hölder-Str. 36 D-70597 Stuttgart Phone: +49 (0) 711/36 54 02 90 Telefax: +49 (0) 711/36 54 02 91 0 [email protected] www.subitec.com

Contact person: Dr. Peter Ripplinger

Employees: 10 As a spin-off of the Fraunhofer Institute for Two other pilot plants in greenhouses are in Interfacial Engineering and Biotechnology operation since 2010. Production range/Services: (IGB), Subitec’s platform technology is based • Photobioreactors on a specially designed low cost panel reactor Superior Technology: • Microalgae biomass built on the airlift-loop-principle (patent grant- • High scalability and modularity • Carotinoids ed world-wide). In contrast to conventional • Use in both greenhouses and on open non- • Omega-3-fatty acids photobioreactors, the flat-panel airlift (FPA) agricultural land • Biogas reactor achieves complete intermixing and • Optimum light supply to the algae resulting • Biodiesel hence improved light distribution to the cells. from targeted flow with static mixers offsets Through the installation of “static mixers” in the limitations caused by poor light distribution Fields of action: liquid flow, algal cells are transported by turbu- and inhibition caused by high light intensity • Agriculture/Food lence from the dark reactor zone to the illumi- • Much higher cell density in comparison with • Environmental Biotech nated surface layer at set intervals. The reactor other reactors • White Biotechnology achieves high cell densities thus enhancing the • Low operating costs due to airlift-driven economy of the production process. intermixing • Net energy production is possible due to The FPA reactor is manufactured from two deep- low energy input drawn half-shells including the static mixers by twin-sheet-technology guaranteeing low production costs (patent granted). In a scale-up process the FPA reactor volume was enhanced from 6 to 180 litres.

In spring 2008, two pilot plants with 1.3 to 4 m³ reactor volume started operation using flue gas from combined heat and power units. © Thomas Ernsting

125 BIOPRO Baden-Württemberg

SYGNIS Pharma AG tional features make them ideally suited for the Im Neuenheimer Feld 515 Next Generation Sequencing equipment. Next D-69120 Heidelberg Generation Sequencing is the fastest growing Phone: +49 (0) 6221/45 46 and most lucrative segment in the genomic Telefax: +49 (0) 6221/45 47 00 space and is potentially the key to opening up [email protected] the potential scale of personalised medicine. www.sygnis.de Early 2013, SYGNIS has been granted the Euro- Contact person: pean and US patent for a new basic technology Pilar de la Huerta CEO/CFO for the detection of protein-protein interactions, a screening platform for the development of novel Branches: drugs. Protein-protein interactions falls within the X-POL BIOTECH, S.L.U. scope of proteomics, a field that is growing in im- (Madrid, Spain) portance for research into new customized drugs. SYGNIS Pharma AG is a biotech company listed SYGNIS’ new platform can be used to improve Employees: 18 in the Prime Standard of the German Stock Ex- the characterization of new drugs in development change. Until the end of 2012 SYGNIS specialised and identification of new therapeutic targets. Production range/Services: in research and development of innovative thera- Polymerases, proteins and tools pies in the area of neurodegenerative diseases. SYGNIS is seeking partnerships or outlicensing for molecular diagnostics and basic in the field of molecular diagnostic, in particu- drug screening platform According to the 2012 newly defined business lar DNA amplification and sequencing. strategy and following the merger with Spain- Fields of action: based X-Pol Biotech, SYGNIS focuses on the In addition outlicensing opportunities for its • Diagnostics development and marketing of novel technolo- drug screening platform (protein-protein inter- • DNA/RNA gies and products in molecular biology, e.g. in actions) are of high interest to SYGNIS. • Proteins/Peptides the field of DNA amplification, sequencing and drug screening. These technologies and products are targeted at the Life Sciences market in the areas of basic, applied and clinical research.

For the key product QualiPhi™, an improved polymerase for amplifying DNA, an exclusive worldwide license has been granted to Qiagen in 2012. The Company expects first revenues based on this license in a short period of time.

In addition to QualiPhi™ the Company has generated new mutant polymerases whose func-

126 SYMBIOSIS – The Analytical Company – is the SYMBIOSIS, business division of Biopharm GmbH offering part of Biopharm GmbH services and solutions for biopharmaceuticals Handelsstr. 15 and classical pharmaceuticals. D-69214 Eppelheim Phone: +49 (0) 6221/53 83 0 SYMBIOSIS integrates the extensive experience Telefax: +49 (0) 6221/53 83 52 and expertise of Biopharm GmbH in analytical [email protected] services of more than 27 years combined with a www.symbiosis.de customer-focused approach driven by excellence in process, communication and quality. GMP Contact person: and GLP certiﬁed we operate according to the Stefan Künzig highest quality assurance standards. Analysis of drug substances and drug products of biopharmaceuticals and classical pharmaceuticals Employees: 35 SYMBIOSIS solutions are customer-driven sets of • Stability testing according to ICH/FDA analytical methods designed to meet regulatory guidelines, incl. storage Production range/Services: requirements. SYMBIOSIS solutions are designed • Release testing SYMBIOSIS offers an extensive set to accelerate drug product development and to • Development and validation of analytical of analytical methods for a wide provide analytical support throughout drug prod- methods in accordance with ICH/FDA range of substances from small uct life cycles. An extensive range of methods guidelines molecules to antibodies. We sup- combined with our expert knowledge provides • Comparability testing port you through all stages of the accurate analysis and consistent results in accor- (incl. Biosimilars/Biobetters) development life cycle of your pro- dance with GMP and GLP requirements. • Safety testing, testing of clinical trial samples. duct from discovery to market.

SYMBIOSIS offers an extensive set of analytical Fields of action: methods for a wide range of substances from • Analytics small molecules to antibodies. We support you • Biotechnological Services through all stages of the development life cycle • Diagnostics N-terminal protein sequencing using Edman Sequencer (© SYMBIOSIS) of your product from discovery to market. • Proteins/Peptides • Therapeutics • Tissue Engineering

Cell based assays (© SYMBIOSIS)

127 BIOPRO Baden-Württemberg

SYNIMMUNE GmbH Auf der Morgenstelle 15 D-72076 Tübingen Phone: +49 (0) 7071/29 78 843 Telefax: +49 (0) 7071/29 35 272 [email protected] www.synimmune.com

Contact person: Dr. Ludger Große-Hovest (CSO) SYNIMMUNE GmbH is a biotechnology SYIMMUNE have pioneered this field from the company focusing on the development of mid-80ies and have contributed significantly to Production range/Services: optimized mono- and bispecific antibodies for the development of recombinant antibody scaf- Synimmune is currently developing improved immunotherapy of hematopoietic folds that allow for the production of bispecific two optimized antibodies, one and solid malignancies. antibodies with improved stability and function. mono- and one bi-specific antibody, for the treatment of acute The company was founded in 2010 as a spin- SYNIMMUNE’s goal is to enhance the therapeu- myeloid leukemia (AML). A third off of the Department of Immunology at the tic efficacy of antibody treatment by improving lead compound, a bi-specific anti- University of Tübingen. the selective activation of immune cells, and to body directed against the tumor bridge the “translational gap” between concep- vasculature, is in the pre-clinical Research activities at SYNIMMUNE focus on tion and clinical evaluation as fast as possible. To development and will be used the development of third generation anti-tumor this end, SYNIMMUNE is establishing its own for the treatment of solid tumors. antibodies with further improved therapeutic GMP-compliant production unit and works in Synimmune is co-developing with activity. A common theme of the strategies close co-operation with the University Hospital industrial and academic partners pursued is the preservation of the selectivity in Tübingen. The development, GMP-compliant bispecific antibodies based on of antibody effector functions, that is their production and compassionate need application Synimmune’s proprietary bispecific dependency upon specific binding to an antigen. of optimized third generation antibodies has antibody platform. In SYNIMMUNE’s view, this is best achieved by been performed within three years. This has bispecific antibodies capable of inducing target been achieved within a project supported by the Fields of action: cell-restricted activation of immune effector GO-Bio program of the BMBF. SYNIMMUNE • Proteins/Peptides cells via receptors such as CD3 and CD28 on T has originated from this program and will • Therapeutics cells, and CD16 on NK cells. The founders of maintain and foster its academic roots.

128 Synovo GmbH Paul-Ehrlich-Str. 15 D-72076 Tübingen Phone: +49 (0) 7071/96 43 25 Telefax: +49 (0) 7071/96 43 26 [email protected] www.synovo.com

Contact person: Dr. Michael Burnet

Synovo GmbH is a drug discovery company provide fast data turn-around to early phase Employees: 23 focussing on inflammatory and bone diseases. projects. Our experience is that rapid Synovo provides pharmacology and chemistry feedback to discovery chemistry is required in Production range/Services: services for clients in the pharmaceutical and order to most efficiently and cost effectively • Pharmacological testing of biotechnology industries. prioritise leads before resources are expended substances on less promising areas. As a consequence, • Models for bone diseases Synovo’s pharmacology services include we routinely organise studies to meet tight • Models for inflammatory diseases efficacy studies in a range of models including time-lines and limited compound supplies. • Pharmacokinetics those relevant to rheumatoid arthritis, • Synthetic chemistry osteoporosis, osteoarthritis and sepsis. Synovo’s customers are drawn from throughout • Compound purification These studies are often combined with Europe, Australia, Canada and the US and • Compound formulation pharmacokinetic and formulation studies to include both small and large firms. We support the selection of optimal conditions welcome enquiries and will always do our Fields of action: and formulations. best to assist in any technical matter related to • Analytics our business area. • Biotechnological Services In support of the pharmacology activities, • Cells/Cell Lines Synovo provides synthetic chemistry services • Contract Research in the areas of analog synthesis, scale-up and • Therapeutics formulation exploration. Synovo’s team of chemists have a broad experience of medicinal chemistry and have completed a wide range of tasks from small parallel chemistry collections to specific elaboration of analog series. To maintain the quality of our synthetic products, we routinely employ preparative HPLC. This capacity can also be provided to third parties. Synovo’s main goal in its service business is to

129 BIOPRO Baden-Württemberg

TETEC AG Aspenhaustr. 18 D-72770 Reutlingen Phone: +49 (0) 7121/514 87 60 Telefax: +49 (0) 7121/514 87 61 [email protected] www.tetec-ag.com

Contact person: Dr. Klaus Maleck, MBA

Employees: approx. 50 TETEC AG: New chances through help patients with chronic back pain (painful Production range/Services: regenerative medicine disc) and herniated discs. • NOVOCART 3D • NOVOCART Inject Using the body’s own tissue, millions of Our product portfolio also offers a cell-free • NOVOCART Basic patients will have the chance of successful material, NOVOCART® Basic, to be used • Med tech treatment of cartilage damage, which cannot mainly in smaller cartilage defects. be properly addressed with today’s medical Fields of action: approaches. TETEC develops innovative Affiliated with B. Braun/Aesculap, TETEC • Cell/Cell Lines therapies for orthopedic indications with an can provide an outstanding distribution net- • Tissue Engineering expert team of scientists and specialists. work. We work actively to share our know- TETEC was founded in Tübingen in the year ledge with the specialist MDs through pro- 2000 with the goal to develop novel treat- fessional user training and support with the ments for tissue repair. The company has ultimate goal to improve the quality of life today approx. 50 employees, bringing with of our patients. them expertise in a wide range of disciplines such as cellular and material science, clinical and pharmaceutical development and regulatory affairs. TETEC is developing new procedures for the treatment of complex cartilage damages and diseases affecting the human skeletal and locomotion systems.

With NOVOCART® 3D and NOVOCART® Inject, we set new benchmarks in the treatment of cartilage damages and with NOVOCART® Disc we are currently investigating how to best

130 Teva’s Expertise in Biotechnology TEVA GmbH Graf-Arco-Str. 3 Teva has a brand base in Germany, with D-89079 Ulm innovative drugs, brand products, generics Phone: +49 (0) 731/40 20 2 and over-the-counter medicines. With its Telefax: +49 (0) 731/40 27 83 2 diversified portfolio, Teva ranks third in the [email protected] German retail market. In the German head- www.teva.de quarters in Ulm and the site in Blaubeuren/ Weiler, Teva has state-of-the-art production Contact person: facilities both for chemical products and for Dr. Hermann Allgaier the production of biotechnological agents. Internationally Teva, whose company head- Production range/Services: quarters are in Israel, is among the 10 largest Development and manufacture of pharmaceutical concerns worldwide and is biopharmaceuticals with emphasis the world market leader among generics bridge’ is first attached to the amino acid on Biosimilars and Me-Better- enterprises. threonine in position 134 of the Filgrastim Products, GlycoAdvance® and molecule to which the polyethylene glycol GlycoPegylation® platform techno- Product Pipeline (PEG) ‘tail’ can then be specifically attached. logy for proteins with sophisticated characteristics With ratiograstim and TevaGrastim, Teva Highly efficient multipurpose plant developed the very first G-CSF biosimilar, Fields of action: which has been successfully placed in the At the Ulm site Teva has its own highly • Therapeutics German market for two years now. The same efficient multipurpose plant to manufacture is true of Teva’s own development Eporatio, biotech active ingredients from mammalian a biotechnologically produced erythropoe- cell cultures. Teva controls the whole supply tin. With the company’s own development chain for Lipegfilgrastim, from production of Lipegfilgrastim, a long acting recombinant the Filgrastim intermediate product XM21, the G-CSF, another biotechnologically produced enzymes and reagents necessary for the pegyla- preparation for supportive therapy is short- tion reaction and the aseptic bottling of the ly expected to receive approval for release drug. Certain enzymes and reagents, as well as throughout the EU. Lipegfilgrastim will be the active agent itself, are produced directly in used to treat cancer patients with neutrope- the company’s own biotechnological multipur- nia in order to stimulate the bone marrow pose plant. The required testing and approval to produce white blood cells to reduce procedures also take place at Teva. The plant the duration of severe neutropenia. When has also been approved by the FDA for the developing this product Teva used the new production of Lipegfilgrastim and has received platform technology of GlykoPEGylierung®. authorization for this product to be supplied In this two-stage enzymatic approach a ‘sugar to the United States market.

131 BIOPRO Baden-Württemberg

TherapySelect Dr. Frank Kischkel TherapySelect Dr. Frank Kischkel is a biotech TherapySelect cooperates with KPS Carl-Bosch-Str. 4 and medtech company located in Heidelberg, Diagnostics GmbH in order to offer patients D-69115 Heidelberg which belongs to the biotechnology cluster molecular gene profiling of their tumors Phone: +49 (0) 6221/89 36 15 2 Rhine-Neckar (BioRN). TherapySelect‘s focus is in combination with the data analysis. The Telefax: +49 (0) 6221/89 36 15 3 the development, clinical validation, marketing service is called ONCOMPASSTM. The inten- [email protected] and sales of diagnostic tests for cancer patients. So tion is to know the therapeutic consequence www.therapyselect.de its field of activity is the personalized medicine resulting of the tumor gene profile. This (or personalized oncology). The company‘s aim is cooperation gives information not only on Contact person: to increase patient‘s survival and quality of life as the established targeted-drugs but also on the Dr. Frank Kischkel well as to reduce the costs in health care system. targeted-drugs in clinical development and whether they might be effective for the par- Production range/Services: TherapySelect has three main areas of activity. ticular patient. As a service there is also the • Diagnostic test for cancer patients Firstly development and sales of own or licensed patient assistance service which helps to enter • Chemotherapy resistance assay products, secondly distribution of other diagnostic into a clinical trial, if wanted by patients or (CTR-Test®) tests, and thirdly offering its diagnostic platform(s) physicians. (The CTR-Test® is a diagnostic for pharma companies product development. tool to predict ineffectiveness of Unsuccessful clinical trials are the most expen- chemotherapies through in vitro TherapySelect sales its own clinically well sive obstacle in drug development. By com- testing of living tumor cells from validated chemotherapy resistance assay (CTR- bining diagnostic tools with the drug already individual patients.) Test ®) worldwide. The test is an in vitro che- during clinical trials, one increases the success • ONCOMPASSTM moresistance assay on living tumor cells. The of the clinical development and makes the • Patient assistance services CTR-Test® has shown in various clinical trials to drug more efficient if it is only administered to • Pharma services be greater than 95% accurate in predicting inef- patients which have an increased susceptibility fectiveness of chemotherapies prior to admini- towards the drug. The CTR-Test® is such a Fields of action: stration of the drugs. Thus the CTR-Test® saves diagnostic technology. With this test all drugs, • Diagnostics patients toxicity and enhances life quality. In which act directly onto the target cells, can be addition the further development of the CTR- tested and assessed. TherapySelect offers the Test ® technology as a platform for new products technology to pharma companies for all clinical is supported by governmental grants. trial phases worldwide.

132 As the ImmunoDiagnostic experts within Thermo Fisher Scientiﬁc Thermo Fisher Scientific, formerly known as - Phadia GmbH Phadia with headquarters in Uppsala, Sweden, Munzinger Str. 7 we develop, manufacture and market complete D-79111 Freiburg blood test systems to support the clinical dia- Phone: +49 (0) 761/4 78 05 0 gnosis and monitoring of allergy, asthma and Telefax: +49 (0) 761/4 78 05 120 autoimmune diseases. For almost 40 years, we [email protected] have been the global leader in allergy testing www.thermoscientific.com/phadia and have become one of the world’s leading autoimmune disease test providers. Our 1,300 Contact person: employees world-wide serve more than 3,000 Heiko von Bachmann laboratories in more than 60 countries. Employees: 1300 The center of excellence in Freiburg, Germany, is the home of research, development, produc- Production range/Services: tion and marketing of our autoimmunity tests. Blood test systems supporting the clincial diagnoses of allergies and Thermo Fisher Scientific - the leader in ser- autoimmune diseases ving science - solves complex analytical issues, improves diagnostics and increases productivity. Fields of action: We enable our customers to make the world • Analytics healthier, cleaner and safer. • Diagnostics • Proteins/Peptides

133 BIOPRO Baden-Württemberg

TICEBA GmbH About TICEBA Tissue & Cell Banking Im Neuenheimerfeld 517 TICEBA is a highly innovative German life sci- D-69120 Heidelberg ence company, working in the field of stem cell Phone: +49 (0) 6221/71 833 0 research and regenerative medicine. Telefax: +49 (0) 6221/71 833 29 [email protected] Based upon its own research and exclusively www.ticeba.com licensed medical procedures, TICEBA practices the sampling, qualitative analysis, and long- Contact person: term storage of adult stem cells taken from Dr Christoph Ganss, MD human skin. The process employs the latest international research findings and the highest Employees: 17 international standards.

Branches: TICEBA is the first private tissue bank world- TICEBA is the only company to dispose of a Offices and laboratory at wide offering its clients the personal and individu- global patent for the evaluation of the quality technology park Heidelberg al cryogenic storage of their skin tissue and the of stem cells of the skin. Professor Dr Markus stem cells contained therein – as a unique ser- Frank, MD is scientific counselor to TICEBA. Production range/Services: vice for health prophylaxis on the highest level He is a scientist for basic research at the • Tissue & Cell Banking worth the expense and in accordance with the “Transplantation Research Center of Brigham • Discovery of the new ABCB5 latest developments of science and technology. and Women’s Hospital and Children’s glycoprotein by Professor Dr Hospital Boston, Harvard Medical School”. Markus Frank, which marks the TICEBA was founded by the physician and His focus in research is on adult stem cells of pluripotent stem cells in the skin entrepreneur Dr Christoph Ganss, MD in the skin, transplantation immunology as well • Global business activities the year 2003. The company started its busi- as cancer research. He is the one who has ness operations on 1 March 2005. TICEBA is discovered ABCB5 P-glycoproteins that play Fields of action: located in the technology park in Heidelberg, a key role with regard to adult stem cells of • Biotechnological Services Germany. The manufacturing license within the skin and multidrug resistance. Professor • Cells/Cell Lines the meaning of section 20b and section 20c Frank has been awarded several scientific was granted in January 2009. prices and scholarships.

134 Trenzyme GmbH Byk-Gulden-Str. 2 D-78467 Konstanz Phone: +49 (0) 7531/12 29 00 Telefax: +49 (0) 7531/12 29 01 1 [email protected] www.trenzyme.com With more than 12 years of experience as full customizes molecular biology, protein bioche- service supplier for the life science industry, we mistry and cell culture expertise for its clients. Contact person: have a clear mission: Trenzyme is a DIN EN ISO 9001:2008 certified Dr. Reinhold Horlacher company. Accelerating your innovation and saving valua- Employees: 10 ble research time & budget! Our core competences are: • Cell line development Production range/Services: Our life science experts together with an out- • Protein expression and purification • From gene to cell line standing collection of state-of-the-art laboratory (E.coli, insect cells, yeast) • Cell culture innovation equipment and technology allow us to always • Gene synthesis and custom cloning • Cell line development fulfill our clients‘ needs at highest quality stand- • Single cell cloning ards and maximum pace. Trenzyme is a privately owned German con- • Protein expression tract research organization offering highly indi- • Protein purification As modular life science full service supplier we vidualized and modular services. • Highly customized services offer any research and development challenge • Gene synthesis in one-stop for our business partners. Founded in 2000, Trenzyme has steadily in- • Custom cloning creased its customer base and enjoys long-term With scientific professionals in each individu- business relationships with regional and global Fields of action: al life science field Trenzyme combines and life science players across all industries. • Biotechnological Services • Cells/Cell Lines • Custom Production • DNA/RNA • Production Organisms • Proteins/Peptides

135 BIOPRO Baden-Württemberg

varionostic GmbH Söflinger Str. 100 D-89077 Ulm Phone: +49 (0) 731/36 08 07 56 Telefax: +49 (0) 731/36 08 07 54 [email protected] www.varionostic.de

Contact person: Uwe Gerstenmaier varionostic – the DNA Methylation Expert valuable information on the gene activity varionostic is Europe’s leading expert for DNA in the human genome under certain condi- Employees: 6 methylation analysis using newest platforms of tions. The methylation level of specific regions Pyrosequencing and MassARRAY. We offer our of the DNA is especially important for cancer Production range/Services: customers from industry and academia outstand- research but also for neuroscience e.g. psychia- • DNA methylation assays ing tailored services from assay design to data try and other academics. (customized and predesigned/ analysis. Scientists can also profit from our pre- ready-to-use) designed methylation assays developed within varionostic, as THE methylation expert, gives you • Epigenetics our own research facilities. Our unique speciali- quantitative data on the methylation of the CpG • Pharmacogenetics sed competence is the basis for highest quality regions and single CpGs you are interested in. • Clinical genetics in epigenetic research and services to oncology, • Pyrosequencing service neurosciences, stem cell projects etc. Research & Development • Capillary sequencing service Together with partners from clinical research and • Realtime PCR service Additional services for epigenetic research industry, varionostic is performing its own epige- • MassARRAY service include genotyping, allele quantification, netic research. Our objective is to continuously (MALDI-TOF) short read sequencing and species identifica- improve our service, in particular by developing • Accreditation: DIN EN ISO/IEC tion. With our state-of-the-art lab (including predesigned methylation assays. 17025:2005 (Genetic Diagnostics) Pyrosequencing, MassARRAY/MALDI-TOF, capillary sequencing and qPCR) we can detect Fields of action: all types of snips, polymorphisms and muta- • Analytics tions. Besides human samples, the company • Biotechnological Services also runs typing of BACs and other species. • DNA/RNA Lab has an accreditation and is competent under the terms of DIN EN ISO/IEC 17025:2005 in the fields of genetic diagnostics.

DNA methylation and gene activity Quantitative DNA methylation analysis gives

136 VAXIMM GmbH Julius-Hatry-Str. 1 D-68163 Mannheim Phone: +49 (0) 621/835 968 70 Telefax: +49 (0) 621/835 968 99 [email protected] www.vaximm.com

Contact person: Dr. Heinz Lubenau

Developing Active Anti-angiogenic Besides VXM01, VAXIMM has a pipeline of Employees: 6 Immunotherapies for Cancer Patients complementary candidate vaccines on the same platform. VXM06, targeting a prominent Product range/Services: VAXIMM is a company that is primarily focused tumor-specific antigen, recently completed ani- • Development of active anti- on developing active immunotherapies (vac- mal proof-of-concept. angiogenic immunotherapies cines) for patients suffering from cancer. Our for cancer patients initial product candidate VXM01 is targeting the VXM01 has started human clinical trials in • Oncology tumor vasculature, which is essential for tumors December 2011. VXM01 has successfully com- • Immunology to grow beyond microscopic size. VXM01 has pleted a first-in-man safety and biomarker trial • R&D Therapeutics shown impressive anti-tumor activity in various in pancreatic cancer patients, conducted at the • Preclinical animal studies testing different tumor types, University Hospital in Heidelberg. different experimental setups, and different out- Fields of action: come measures. At the same time, the vaccine For further information, please visit • Therapeutics was remarkably well tolerated in these animals. www.vaximm.com

137 BIOPRO Baden-Württemberg

Vetter Pharma Meet Vetter International GmbH Vetter is a leading contract development and Eywiesenstr. 5 manufacturing organization (CDMO) that speci- D-88212 Ravensburg alizes in the aseptic filling of syringes, cartridges Phone: +49 (0) 751/37 00 0 and vials. The company has extensive experience Telefax: +49 (0) 751/37 00 40 00 with biologics and other complex compounds, [email protected] including monoclonal antibodies, peptides, inter- www.vetter-pharma.com ferons and vaccines. Collaborating with pharma/ biotech clients worldwide, Vetter supports Contact person: products from preclinical development through Oskar Gold, Vice President global market supply. Through its U.S. and KAM & Corporate Marketing European facilities, Vetter Development Service provides state-of-the-art support for early-stage Branches: products, with seamless transfer at Phase III to Vetter Pharma International USA Inc. Vetter Commercial Manufacturing for large-scale 4901 Searle Parkway, Suite 300A production. The company offers state-of-the-art Skokie, IL 60077 technology and innovative processes to promote Vetter Commercial Manufacturing Phone: +1 847 581 6888 product quality and maximize API yield. Vetter Commercial Manufacturing provides Phase Fax: +1 847 581 6880 III manufacturing through global market supply, [email protected] Vetter Development Service featuring: At Vetter Development Service, we partner with • Fill and finish Employees: approx. 3000 our clients from preclinical development through • Analytical service Phase III, featuring: • Regulatory support Product range/Services: • Formulation support • Product life cycle management • Vetter Development Service • Process development • Vetter Commercial • Clinical trial manufacturing Vetter Packaging Solutions Manufacturing • Analytical service Vetter Packaging Solutions helps our clients match • Vetter Packaging Solutions • Regulatory support their product with the appropriate drug-delivery system (primary packaging); secondary packaging, Fields of action: and packaging services, featuring: • Custom Production • Customized packaging development • Specialized technologies • Proven platform technologies • Packaging services • Logistic services

Dosage Forms Syringes, cartridges, vials

138 Viscofan BioEngineering Viscofan BioEngineering

a Business Unit of Viscofan BioEngineering is a business unit Naturin Viscofan GmbH of Viscofan S.A., the worldwide leader in the Badeniastr. 13 manufacture of collagen, cellulose, fibers and D-69469 Weinheim plastic products for the food industry. The com- Phone: +49 (0) 6201/8 63 58 pany has facilities in Europe, America and Asia, Telefax: +49 (0) 6201/8 62 26 and sells its products in more than 160 countries [email protected] all over the world. It is listed on the Spanish www.viscofan-bioengineering.com Stock Market. Viscofan BioEngineering focuses its activities on the development of innovative Contact person: biomaterials on the basis of collagen for appli- academic groups in Germany, Spain and the US Petra Görg cation in cell culture, tissue engineering and to research and develop the use of these bio- regenerative medicine. materials as cell-based assays and as cell-seeded Employees: 5 implants in selected medical indications, in the Their latest development is the Collagen Insert, field of e.g. heart disease or age-related macular Product range/Services: which contains a self supporting and semi-per- degeneration (AMD). • Collagen cell carrier meable collagen membrane. The Insert is suited • Collagen inserts for air lift cell cultivation. The company has offices and laboratories • Regenerative Medicine in Weinheim (Germany) as part of Naturin Besides the further development of its innova- Viscofan GmbH, the German subsidiary of Fields of action: tive collagen scaffolds, Viscofan BioEngineering Viscofan S.A. and collagen centre of excellence • Supplier has entered into collaborations with several for the whole group. • Tissue Engineering

139 BIOPRO Baden-Württemberg

VIVACELL Biotechnology GmbH Vivacell Biotechnology GmbH is a privately owned Ferdinand-Porsche-Str. 5 contract-based research organisation (CRO) that D-79211 Denzlingen provides specialised in vitro and in vivo models Phone: +49 (0) 7666/90 28 77 for testing and developing pharmaceutical and Telefax: +49 (0) 7666/90 28 78 phytopharmaceutical compounds, extracts and [email protected] nutraceuticals. VivaCell Biotechnology GmbH was Dermatology / cosmetics www.vivacell.de founded in 1999 as a spin-off of the University of Fibroblast and keratinocyte proliferation and migra - Freiburg Medical School. In 2003, Vivacell moved tion, Anti-inflammatory activity, Anti-oxidant Contact persons: to his own facility in Denzlingen. VivaCell’s precli- capacity, UVB induced ROS, PPARĮ, PPARį Dr. Kurt Appel nical services include standard protocols and pro - and PPARȖ, collagen, metalloproteinases, Dermal Dr. Bernd Fiebich tocols adapted to the needs of the customers using papilla cells, growth fractors, Hair (5alpha-reduc- a variety of in vitro and in vivo systems. VivaCell is tase I and II, dermal papilla cells, growth factors Branches: combining highly qualified cellular and molecular (IGF, KGF, PDGF, TGF etc.) TERT activity. VIVACELL ESPANA (E) biology knowledge and expertise in various fields with a focus on immunology and neurobiology. Oncology / angiogenesis Employees: 6 At VivaCell, we offer complete research projects Proliferation inhibition assays (human tumor from basic R&D up to pre-clinical research (GLP) cell lines), clonogenic assays (human tumor Production range/Services: in one hand. Our clients do not have to gather the xenografts, human tumor cell lines, and hemato- • Immunmodulation / inflammation research data from various CROs. poetic stem cells). Subcutaneous models, ortho - • CNS topic models with human xenografts, and murine • Dermatology / cosmetics Immunmodulation and inflammation tumor models. 3D in vitro angiogenesis assay. • Allergy Proliferation/activation of T-/B-lymphozytes, • Oral care phagocytic activity, coagulation assays. Primary Allergy • Oncology / angiogenesis human monocytes, T-/B-lymphozytes, fibro- Histamine release, histamine induced inflam- • ADME blasts, keratinocytes, melanocytes, endothelial mation, mast cell stabilization. • Toxicity cells, colon epithelial cells, and tumor cell lines • Pharma (parameters e.g prostaglandins, cytokines). In Oral care • Phytopharmaceuticals vivo models (IBD, CIA etc.). Gingival inflammation (cytokines, prostaglan- • Nutraceuticals dins, MMPs, NF-kappaB), Proliferation of gingi- • Pharmacology CNS studies in vitro and in vivo val fibroblasts, Gingival tissues, Determination Microglia/astrocytes/neurons, cell lines (para- of inflammatory parameters in sulkus samples Fields of action: meters e.g. prostaglandins, cytokines, NO). Or - • Agriculture/Food ganotypic hippocampal slice cultures, Neuro- ADME • Analytics toxicity and neuorprotection, Neuro transmitters Gastrointestinal absorption, blood-brain • Cells/Cell Lines and receptors. In vivo disease models for: barrier, dermal systems, PgP, metabolism • Contract Research stroke, Parkinson’s disease, epilepsy, Huntington’s disease, migraine, peripheral neuropathy, pain, Toxicity anxiety, depression, schizophrenia, etc. Cytotoxicity, genotoxicity, irritation, sensitization, etc.

140 WITec GmbH Lise-Meitner-Str. 6 D-89081 Ulm Phone: +49 (0) 731/1 40 70 0 Telefax: +49 (0) 731/1 40 70 200 [email protected] www.witec.de

Contact person: Harald Fischer ([email protected])

Branches: USA, Singapore WITec is a manufacturer of high resolution opti- optical resolution beyond the diffraction limit can cal and scanning probe microscopy solutions for be easily obtained with the Scanning Near-field Employees: 40 (Germany) scientific and industrial applications. A modular Optical Microscope alpha300 S also featuring product line allows the combination of different AFM and confocal microscopy capabilities. The Production range/Services: microscopy techniques such as Raman, NSOM, award winning TrueSurface Imaging mode allows • High-resolution optical and or AFM in one instrument. Focusing on inno- confocal Raman imaging guided by surface topo- scanning probe microscopes vations and constantly introducing new techno- graphy. TrueSurface Microscopy follows the sur- • Confocal Raman microscopes logies, WITec is the leading expert for a wide face topography with high precision, so that even • Atomic Force microscopes variety of optical, structural, and chemical imaging rough or inclined samples always stay in focus • Scanning near-field optical tasks. Areas of application for WITec’s Imaging while performing confocal Raman imaging. microscopes systems include life science, biomedical research, polymer sciences, pharmaceutics, geoscience, and Fields of action: nanotechnology. • Analytics • Supplier For high resolution chemical imaging the WITec Confocal Raman Microscope alpha300 R provides the ability to perform in-situ Raman imaging at a lateral resolution down to 200 nm. Confocal Raman Microscopy allows imaging of the chemical properties of a sample nondestructively while requiring no staining and only minimal sample preparation if any. Automated measurements on large samples can be easily accomplished with the WITec alpha500 automated Confocal Raman & Atomic Force Microscope. Images with an

141 BIOPRO Baden-Württemberg

Züblin Umwelttechnik GmbH Otto-Dürr-Str. 13 D-70435 Stuttgart Phone: +49 (0) 711/82 02-0 Telefax: +49 (0) 711/82 02-154 [email protected] www.zueblin-umwelttechnik.com

Contact person: Dr. Hans-Georg Edel

Employees: 125 Specialist of environmental technology we employ appropriate methods to stimulate and accelerate degradation processes that would Branches: Stuttgart, Berlin, Chem- ZÜBLIN Umwelttechnik is a leading, interna- otherwise only occur at a slow pace. We can there- nitz, Dortmund, Hamburg, Nurem- tionally oriented environmental engineering fore ensure that the removal of pollutants from berg, Strasbourg, Milan, Cracow company with more than 20 years of experience water, soil or air takes place in a manner that is in the remediation of contaminated sites and friendly to the environment and to your budget. Product range/Services: the cleanup of groundwater, soil and air. • Environmental remediation We establish a balance between the demands of • Biofilm reactors The objective of ZÜBLIN Environmental Bio- economic progress and the need to preserve a • Biological waste air purification technology is to promote the growth of the exist- natural, congenial environment for future gene- • Biological soil decontamination ing microflora in a natural way. Backed by our rations. ZÜBLIN Umwelttechnik offers environ- • BioAirlift extensive know-how and experience in this field, mental technology for human beings. • Biosparging • Biological biogas desulphurisation

Fields of action: • Environmental Biotech

142 Zwisler Laboratorium GmbH Blarerstr. 56 D-78462 Konstanz Phone: +49 (0) 7531/99 11 00 Telefax: +49 (0) 7531/99 11 01 [email protected] www.zwisler-laboratorium.com

Contact person: Dr. Walter Zwisler

Production range/Services: • Quality Control • Invitro Pyrogen Testing (MAT) • Endotoxin Test (LAL) • Integrity Tests Microbial contamination under fluorescence microscope (Microbial Ingress Test) • Cytotoxicity Test for Zwisler Laboratorium GmbH is a privately Medical Devices owned service laboratory located in Konstanz, • Reprocessing Validation Germany, founded in 2003. for Medical Devices • Bioburden Test Zwisler Laboratorium GmbH is ISO 17025 • Development of customer- accredited and is GLP- and GMP-certified. related Tests • Microbiology Customers The Lab is focused on microbiological and • Medical Device Manufacturer cell culture methods to demonstrate the high Invitro Pyrogen Test (human blood) with Medical Device • Packaging and Pharmaceutical quality production process of our customers. Industry We are a partner to achieve highest quality • Mainly from Europe and USA standards. Fields of action: A main focus - with worldwide customers - is • Analytics the Invitro Pyrogen Testing (MAT, EP 2.6.30) • Biotechnological Services of Pharmaceuticals and Medical Devices. • Cells/Cell Lines

Another main Field of Action are Integrity Tests for Pharmaceutical and Cosmetic Packaging (Microbial Ingress Tests). Cell culture under the microscope (Cytotox-Test)

143 BIOPRO Baden-Württemberg

144 Biotech Company Overview

145 BIOPRO Baden-Württemberg

146 Page Company City

29 4base lab GmbH Reutlingen

30 ACROVIS® biostructures GmbH Dornstadt

31 Affimed Therapeutics AG Heidelberg

32 Agilent Technologies Sales & Services GmbH & Co. KG Waldbronn

33 Agrano GmbH & Co. KG Riegel am Kaiserstuhl

34 Aldevron Freiburg GmbH Freiburg

35 Anoxymer GmbH Esslingen

36 Apara Bioscience GmbH Denzlingen

37 Ascendis Pharma GmbH Heidelberg

38 ATG:biosynthetics GmbH Merzhausen

39 Atoll GmbH Weingarten

Baden-Württemberg International Agency for 7 Stuttgart International Economic and Scientific Cooperation

40 BERTHOLD TECHNOLOGIES GmbH & Co. KG Bad Wildbad

41 Biametrics GmbH Tübingen

42 Bioassay-Labor für biologische Analytik GmbH Heidelberg

43 BioCat GmbH Heidelberg

44 BioChem GmbH Karlsruhe

45 biomers.net GmbH Ulm

46 BIOMEVA GmbH Heidelberg

47 BIOPHARM GmbH Heidelberg

6 BIOPRO Baden-Württemberg GmbH Stuttgart

8/9 BioRegion Freiburg c/o Technology Foundation BioMed Freiburg Freiburg

10/11 BioRN Network e.V. Heidelberg

12/13 BioLAGO Konstanz

14/15 BioRegio STERN Management GmbH Stuttgart

16/17 BioRegion Ulm e. V. Ulm

48 BioRépair GmbH Sinsheim

49 biosyn Arzneimittel GmbH Fellbach

17 BiotechnologieZentrum Ulm Ulm

9 BioTechPark Freiburg Freiburg

147 BIOPRO Baden-Württemberg

Page Company City

50 BioTeSys GmbH Esslingen

51 BioTissue Technologies GmbH Freiburg

52 BMG LABTECH GmbH Ortenberg

53 Boehringer Ingelheim Biopharmaceuticals GmbH Ingelheim

54 CANDOR Bioscience GmbH Wangen

55 cecolabs UG Tübingen

56 CeGaT GmbH Tübingen

57 Cellca GmbH Laupheim

58 Cellendes GmbH Reutlingen

59 CellGenix GmbH Freiburg

60 Cellzome GmbH Heidelberg

61 CETICS Healthcare Technologies GmbH Esslingen a. N.

62 ChemCon GmbH Freiburg

63 Comprehensive Biomarker Center GmbH Heidelberg

64 Computomics GmbH & Co. KG Tübingen

65 Crinotec GmbH Tübingen

66 Curetis AG Holzgerlingen

67 CureVac GmbH Tübingen

68 Cytonet GmbH & Co. KG Weinheim

69 da-cons GmbH data analysis & consulting Eggenstein-Leopoldshafen

70 DIARECT AG Freiburg

71 DSM Nutritional Products GmbH Grenzach Grenzach-Wyhlen

72 EMC microcollections GmbH Tübingen

73 ExploSYS GmbH Leinfelden-Echterdingen

74 FRUTAROM Savory Solutions GmbH Stuttgart

75 GATC Biotech AG Konstanz

76 Genaxxon bioscience GmbH Ulm

77 Gene Bridges GmbH Heidelberg

78 Genotype GmbH Wilhelmsfeld

79 Glycotope Biotechnology GmbH Heidelberg

80 Graffinity Pharmaceuticals GmbH Heidelberg

148 Page Company City

81 greenovation Biotech GmbH Heilbronn

82 Greiner Bio-One GmbH Frickenhausen

83 Hain Lifescience GmbH Nehren

84 HB Technologies AG Tübingen

85 Heidelberg Pharma AG Ladenburg

86 HiSS Diagnostics GmbH Freiburg

87 Hydrotox GmbH Freiburg

88 IBAM GbR Dr. Rainer Knörle & Dr. Peter Schnierle Denzlingen

89 ibt- Immunological and Biochemical Testsystems GmbH Binzwangen

90 immatics biotechnologies GmbH Tübingen

91 Insilico Biotechnology AG Stuttgart

92 Jobst Technologies GmbH Freiburg

93 Junker Filter GmbH Sinsheim

94 LABOR DR. MERK & KOLLEGEN GmbH Ochsenhausen

95 Labor für DNA-Analytik Freiburg

96 Logopharm GmbH March-Buchheim

97 Mediagnost GmbH Reutlingen

98 MEDICHEM Diagnostica GmbH & Co. KG Steinenbronn

99 Medicyte GmbH Heidelberg

100 menal GmbH Gesellschaft für medizinisch naturwissenschaftliche Laboranalytik Emmendingen

101 MetaSystems GmbH Altlussheim

102 micro-biolytics GmbH Esslingen

103 MicroMol GmbH + FPQS Karlsruhe

104 Multi Channel Systems MCS GmbH Reutlingen

105 nadicom Gesellschaft für angewandte Mikrobiologie mbH Karlsruhe

106 nanoTools Antikörpertechnik GmbH & Co. KG Teningen

107 npi electronic GmbH Tamm

108 n-bio GmbH Konstanz

109 Oncotest GmbH Freiburg

110 PANATecs GmbH Heilbronn

111 PEPperPRINT GmbH Heidelberg

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Page Company City

112 Peptide Specialty Laboratories GmbH Heidelberg

113 PromoCell GmbH Heidelberg

114 ProQinase GmbH Freiburg

115 Q-bios GmbH Mannheim

116 ravo Diagnostika GmbH Freiburg

117 rent-a-lab Dr. Carsten Tober Reutlingen

118 Rentschler Biotechnologie GmbH Laupheim

119 RHEACELL GmbH & Co. KG Heidelberg

Roche Diagnostics GmbH 120 Mannheim Roche Diagnostics Deutschland GmbH

121 Sciomics GmbH Heidelberg

122 SEARCH-LC GmbH Heidelberg

123 Sensovation AG Radolfzell

124 SGS M-Scan GmbH Freiburg

125 Subitec GmbH Stuttgart

126 SYGNIS Pharma AG Heidelberg

127 SYMBIOSIS Eppelheim

128 SYNIMMUNE GmbH Tübingen

129 Synovo GmbH Tübingen

11 Technologiepark Heidelberg GmbH Heidelberg

TFU – TechnologieFörderungsUnternhemen GmbH 17 Ulm BiotechnologieZentrum Ulm

130 TETEC AG Reutlingen

131 TEVA GmbH Ulm

132 TherapySelect Dr. Frank Kischkel Heidelberg

133 Thermo Fisher Scientific - Phadia GmbH Freiburg

134 TICEBA GmbH Heidelberg

135 Trenzyme GmbH Konstanz

17 TTR Technologieparks Tübingen-Reutlingen GmbH Reutlingen

136 varionostic GmbH Ulm

137 VAXIMM GmbH Mannheim

150 Page Company City

138 Vetter Pharma International GmbH Ravensburg

Viscofan BioEngineering 139 Weinheim a Business Unit of Naturin Viscofan GmbH

140 VIVACELL Biotechnology GmbH Denzlingen

141 WITec GmbH Ulm

142 Züblin Umwelttechnik GmbH Stuttgart

143 Zwisler Laboratorium GmbH Konstanz

151 BIOPRO Baden-Württemberg

Notes

152 Imprint

// Publisher BIOPRO Baden-Württemberg GmbH Breitscheidstraße 10 | 70174 Stuttgart/Germany

// Editorial Management Introduction and company database BIOPRO Baden-Württemberg GmbH

// Design & Photos BIOPRO Baden-Württemberg GmbH

// Production Designwerk Kussmaul

BIOPRO Baden-Württemberg GmbH Breitscheidstraße 10 | 70174 Stuttgart/Germany Phone +49 (0) 711/21 81 85-00 | Fax +49 (0) 711/21 81 85-02 E-Mail: [email protected] | www.bio-pro.de

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BIOPRO Baden-Württemberg GmbH • Breitscheidstr. 10 • 70174 Stuttgart/Germany Phone: +49 (0) 711-21 81 85 00 • Fax: +49 (0) 711-21 81 85 02 • E-Mail: [email protected]