Annual Academic Meeting (Incorporating the Annual Blair Bell Research Society Competition) Joint RCOG/Blair Bell Research Society

Programme – Thursday 27 February

2nd Floor Foyer 9.30am REGISTRATION AND REFRESHMENTS

Main Hall 10.00am Welcome Professor Andrew Horne, Professor of Gynaecology and Reproductive Sciences, University of Edinburgh, Edinburgh

Session I: Free communications (oral presentations) Chairs: Professor Fiona Denison and Professor Siobhan Quenby

Quantifying the Placental Glycocalyx with Lectin Histochemistry 10.10am Colin Down, Clinical Research Fellow Obstetrics and Gynaecology, University Hospitals Bristol NHS Foundation Trust/ University of Bristol Evidence for rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) to increase the risk of developing superimposed pre-eclampsia in pregnant 10.25am patients with established hypertension and chronic kidney disease Julia Zöllner, ST5 NIHR ACF Obstetrics and Gynaecology, St George’s University Hospital NHS Foundation Trust Neuroimaging reveals that in endometriosis, neuropathic pain is associated with provoked brainstem activity in an area with no 10.40am resting connectivity Lydia Coxon, DPhil student, Nuffield Department of Women’s and Reproductive Health, University of Oxford The impact of morbid obesity and weight loss on the immune microenvironment of the endometrium 10.55am Anie Naqvi, 5th Year Medical Student, University of Manchester/ Manchester University Foundation Trust

Programme – Thursday 27 February

Session II: Training Chairs: Dr Stephanie Worton and Dr Katie Morris

11.10am MRC training opportunities Professor Moira Whyte, Head of College of Medicine and Veterinary Medicine, University of Edinburgh

11.30am Training as a scientist Dr David MacIntyre, Reader in Reproductive Systems Medicine, Imperial College London

11.45am Training as a clinical academic Dr Jenny Myers, Clinical Senior Lecturer, University of Manchester

12.00pm Panel Discussion

Session III: Workshops

12.15pm Main Hall  Workshop A: Getting started in … clinical trials Professor Lucy Chappell and Professor Siobhan Quenby

Room: 201  Workshop B: Getting started in … grant writing Professor Fiona Denison and Professor Krina Zondervan

Room: 204  Workshop C: Getting started in … writing guidelines Professor Andrew Horne and Ms Eva Gonzales

Room: 205  Workshop D: Getting started in … finding research posts Dr Jenny Myers and Dr David MacIntyre

3rd Floor Foyer 1.00pm LUNCH WITH POSTER VIEWING AND JUDGING Programme – Thursday 27 February

Main Hall Session IV: Free communications (oral presentations) Chairs: Dr Jenny Myers and Professor Manu Vatish

The effect of a six-week dietary supplement of omega-3 fatty acids and vitamin D on in vitro human embryo development: The 2.00pm PREPARE*’ double blinded randomized controlled trial Alexandra Kermack, NIHR Clinical Lecturer, University of Southampton Uterine gland secretions direct trophoblast stem cell differentiation 2.15pm Isabella Smith, Medical Student, St Mary's Hospital, Manchester/University of Manchester Making BUMP work: Intervention development in a large randomised controlled trial of blood pressure self-monitoring in pregnancy 2.30pm Hannah Wilson, Senior Research Midwife/ Coordinating Midwife for the BUMP Trial, Department of Women and Children's Health, King's College London/ Nuffield Department of Primary Care Health Sciences Use of light-sheet fluorescence microscopy for high resolution 3D 2.45pm imaging of placental volumes Georgia Mappa, PhD Student, University of Leeds

Session V: Genomics Workshop Chairs: Professor Krina Zondervan and Professor Peter Braude

3.00pm The genomics taskforce at RCOG Professor Peter Braude, Emeritus Professor of Obstetrics and Gynaecology, King's College London

3.10pm The 100,000-genome project and endometrial cancer Dr David Church, Cancer Research UK Advanced Clinician Scientist and Honorary Consultant in Medical Oncology, Oxford University Hospitals Foundation NHS Trust

3.30pm Genome editing Dr Helen O’Neill, Lecturer in Reproductive and Molecular Genetics, University College London

3.50pm Interactive panel discussion

3rd Floor Foyer 4.15pm REFRESHMENTS AND POSTER VIEWING

Programme – Thursday 27 February

Main Hall Session VI: Trainee Driven Research and Academic Prize Giving Ceremony Chairs: Professor Andrew Horne and Professor Lucy Chappell

4.45pm 5 years of the UK audit and research collaborative in obstetrics and gynaecology Dr Michael Rimmer, ECAT – MRC Clinical Research Fellow, MRC Centre for Reproductive Health, University of Edinburgh; and Chair of UK Audit and Research Collaborative in Obstetrics & Gynaecology

5.00pm RCOG prize giving

5.10pm Presentations from prize winners Dr Caroline Ovadia Dr Narthana Ilenkovan Miss Chlóe Cuthbert Miss Amanda Leow

3rd Floor Foyer 5.30pm DRINKS RECEPTION ‘Speed dating’ for mentoring and informal networking during the drinks reception to offer an opportunity to speak with senior academics.

7.00pm CLOSE Programme – Friday 28 February

Main Hall 8.15am Blair Bell Research Society Annual General Meeting

2nd Floor Foyer 8.45am REGISTRATION AND REFRESHMENTS

Session VII: Parallel Sessions – Pitch Your Posters Delegates can choose one of the two sessions

Obstetrics Gynaecology Room: Main Hall Room: 201 Dr Nigel Simpson Professor Emma Crosbie Chair(s) Professor Steve Charnock-Jones Professor Dharani Hapangama Seasonal variations in treatment Perceptions of Menstrual Hygiene requirements and neonatal outcomes Education in Southwest Uganda 9.15am in gestational diabetes Lucy Ryder, Medical Student, University of Rachel Fox, Fifth Year Medical Student, Sheffield University of Cambridge Characterisation of a distinct T Determining the Molecular Profile of Regulatory cell phenotype in peri- Low Grade Serous Ovarian Carcinoma implantation endometrium (LGSOC) 9.20am Elizabeth O’Donnell, ST3 Obstetrics and Narthana Ilenkovan, NIHR Academic Clinical Gynaecology, St Mary's Hospital/University Fellow and ST2 in Obstetrics and of Oxford Gynaecology, Department of Oncology and Metabolism, University of Sheffield Increased activation of the placental Diagnosis, Management and unfolded protein response is Prophylaxis of Chronic Lower Urinary associated with reduced maternal Tract Symptoms (LUTS) in Women: Is 9.25am circulating PlGF there room for improvement? Lucy Higgins, NIHR Academic Clinical Melanie Norton, Clinical Fellow, Lecturer, University of Manchester Urogynaecology, Whittington Hospital The assessment of microRNA expression in pregnancies classified as A mixed methods exploration of the a pregnancy of unknown location delays to diagnosis of endometriosis in (PUL) the United Kingdom; a triphasic study 9.30am Christopher Kyriacou, Clinical Research Babu Karavadra, ST2 Obstetrics & Fellow, Tommy's National Centre for Gynaecology, Norfolk and Norwich Miscarriage Research, Imperial College University Hospital London Timing of antenatal steroids in The Early Detection of vulval CAncer women presenting with suspected Through vulval self-Examination preeclampsia and the role of PlGF in (EDuCATE) study: What women and 9.35am targeting their use clinicians think Paula Busuulwa, Clinical Fellow, Guy's and Vanitha Sivalingam, NIHR Clinical Lecturer in St Thomas' Hospital Gynaecological Oncology, University of Manchester Placental taurine uptake promotes a cell survival response to oxidative stress 9.40am Nina El-Ahwany, MRes Student, Maternal and Fetal Health Research Centre, St Mary’s Hospital, Manchester Programme – Friday 28 February

Session VII: Parallel Sessions – Hot Topics Delegates can choose one of the two sessions

Hot topics in research 1 Hot topics in research II Main Hall Room: 201 Dr Nigel Simpson Professor Emma Crosbie and Professor Dharani Chair(s) Professor Steve Charnock-Jones Hapangama Thyroid dysfunction in ART and early Developing prediction models in pregnancy: are we over treating? maternity care Dr Rima Dhillon-Smith, Clinical Lecturer in 10.00am Dr John Allotey, Senior Research Fellow, Early Pregnancy and Reproductive Medicine, Queen Mary University of London Birmingham Women’s and Children’s NHS Foundation Trust

10.20am Discussion Discussion

A collaborative approach to The long road to Mitochondrial improving antenatal care in Nepal Replacement Therapy Dr Abi Merriel, NIHR Academic Clinical Dr Yuko Takeda, Research Associate, 10.30am Lecturer in Obstetrics and Gynaecology, Newcastle Fertility Centre, Newcastle upon North Bristol NHS Trust / University of Tyne Hospitals NHS Foundation Trust Bristol

10.50am Discussion Discussion

3rd Floor Foyer 11.00am REFRESHMENTS

Main Hall Session VIII: Current issues in Women’s Health Chairs: Ms Charlotte Williams and Professor Louise Kenny

11.30am The Role of Mesh in Urogynaecology: Current Issues Dr Sohier El-Neil, Consultant In Urogynaecology and Uro-neurology, University College London

12.00pm Where has the placental microbiome gone? Professor Steve Charnock-Jones, Professor of Reproductive Biology, The Rosie Hospital, University of Cambridge

3rd Floor Foyer 12.30pm LUNCH WITH POSTER VIEWING AND JUDGING Programme – Friday 28 February

Main Hall Session IX: Free communications (oral presentations) Chairs: Dr Neil Ryan and Professor Arri Coomarasamy

tRNA halves: a striking new discovery in preeclampsia 1.30pm William Cooke, Academic Clinical Fellow Obstetrics & Gynaecology, University of Oxford Placental expression of estrogen related receptor γ (ERRγ) is hypoxia-sensitive and is altered in pregnancies complicated by fetal 1.45pm growth restriction Zhiyong Zou, PhD Student, University of Manchester, Faculty of Biology, Medicine and Health, St Mary’s hospital Enhancing classification of endometrial hyperplasia: A strategy for the earlier diagnosis of endometrial cancer 2.00pm Peter Sanderson, Subspecialty Trainee in Gynaecological Oncology, University of Edinburgh Does the symptom of bladder pain influence the urodynamic diagnosis? 2.15pm Alka Bhide, Subspecialty Trainee in Urogynaecology, Department of Urogynaecology, Imperial College NHS Trust

Session X: Prize lecture Chair: Professor Lucy Chappell

2.30pm William Blair Bell Memorial Lecture ‘Global maternal multimorbidity: thrive or survive?’ Dr Mary McCauley, Centre for Maternal and Newborn Health, Liverpool School of Tropical Medicine

3rd Floor Foyer 3.10pm REFRESHMENTS and POSTER VIEWING

Main Hall Session XI: Keynote lecture Chair: Dr Katy Vincent

3.40pm ‘It worked in the lab – does it work in clinical practice’? Professor Arri Coomarasamy, Professor of Gynaecology, Birmingham Women’s Hospital

4.20pm Presentation of Winners of Blair Bell Research Society Competition

4.30pm CLOSE: Professor Andrew Horne and Professor Lucy Chappell