GHS/USC FACULTY CURRICULUM VITAE

Name: Bruce A Lessey, Ph.D., M.D.

Office Address: University Medical Group Phone: 864-455-1600 Department of Obstetrics & Gynecology Fax: 864-455-3095 890 W. Faris Road, Suite 470 Greenville, SC 29605

Education:

Franklin & Marshall College 1969-73 B.A. English University of Delaware 1973-76 B.A. Biology Colorado State University 1976-78 M.S. Zoology Colorado State University 1978-80 Ph.D. Zoology Univ. of Colorado School of Med 1980-84 MD Medicine

Residencies or Post-Doctoral: Residency, Duke University Medical Center, Durham, NC 1984-88 Fellowship, OBGYN, REI, Hospital of the University of Pennsylvania, Philadelphia, PA 1988-1989

Specialty/Board Certification: Reproductive Endocrinology & Infertility 04/94-present

Licensure: South Carolina 23592 North Carolina 29614

Military Service: None

Faculty Appointments:

1976 Teaching Assistant Colorado State University 1977-79 Graduate Research Asst. Colorado State University 1989-93 Assistant Professor Univ. of Pennsylvania School of Med. OB/GYN 1993-95 Assistant Professor Univ. NC at Chapel Hill OB/GYN 1995-00 Associate Professor Univ. NC at Chapel Hill OB/GYN 1989-93 Attending Physician Hospital of the Univ. of Pennsylvania OB/GYN 1993-03 Attending Physician Univ. NC at Chapel Hill OB/GYN 2000-03 Professor Univ. NC at Chapel Hill OB/GYN 2001-03 Professor Univ. NC at Chapel Hill Pathology and Lab. Med. 2003-present Attending Physician GHS University Medical Group REI 2004-present Adjunct Professor Pathology Committee, USC School of Medicine OB/GYN 2007-present Adjunct Professor Pathology & Laboratory Medicine at USC 2011-present Adjunct Professor Dept. Public Health Sciences, Clemson University 2012-present Clinical Professor Dept. Biomedical Sciences, USC School of Medicine Greenville

Administrative Appointments:

2003-2011 Director GHS Department of OBGYN REI 2009-present Lab Director Dept of OB/GYN 2007-2011 Vice Chair, Research Dept. of OBGYN

1 Hospital Appointments/Privileges:

1989-93 Inactive - Hospital of the University of Pennsylvania 1993-03 Inactive - University of North Carolina at Chapel Hill

2003-present Attending Physician Department of Obstetrics and Gynecology Division of Reproductive Endocrinology and Infertility Greenville Health System, University Medical Group, Greenville, SC

Membership in professional/scientific societies: National and International Societies:

1984-present Alpha Omega Alpha Honor Medical Society 2010-present American Association for the Advancement of Science 1987-present American Board of Obstetrics and Gynecology 1992–present American College of Obstetricians & Gynecologists, Fellow 2011–present American Institute of Ultrasound Medicine 1984–present American Society for Reproductive Medicine 2004-present Androgen Excess and Polycystic Ovary Syndrome Society 1983-present The Endocrine Society 2015–present Society for Reproductive Investigation 1987-present Society for the Study of Reproduction 2005-present World Endometriosis Society 2004-present The Endometriosis Association 2014-present European Society of Human Reproduction and Embryology (ESHRE)

Local and Regional Societies:

Alpha Omega Alpha Honor Medical Society – Founding Member, USC SOM Greenville Chapter South Carolina Medical Society The F. Bayard Carter Society The Robert A. Ross Society Sigma Xi, University of North Carolina Chapter South Carolina OB/GYN Society Greenville County Medical Society

National, Regional and Local Committees:

2015-2016 Chairman Endometriosis Special Interest Group ASRM 2014-present Chairman Appointments and Promotions Committee USC SOM - Greenville 2013 Chairman NIH Special Emphasis Panel 201310 ZHD1 DSR-L (50) 2013 Member Student Evaluation and Promotions Committee USC SOM - Greenville 2013-present Chairman Abstract Review Committee EndoSIG ASRM 2012-present Member Translational Research Subcommittee SSR 2012 Chairman NIH U54 Contraception Review Panel ZHD1 DRG-H(53) 2012-present Member Search Committee for the Associate Dean for Research And Graduate Studies USC SOM 2011-present Vice Chairman Endometriosis Special Interest Group ASRM 2011-present Member Nominations Committee Soc Gynecol Invest 2008-present Member Physician Advisory Council GHS 2008-present Member Appointment and Promotions Committee GHS 2008 Member Distinguished Research Award Selection USC SOM 2008 Member Chairman Search Committee OB/GYN GHS 2006-present Member Clinical Research Committee OB/GYN GHS 2004-present Member Crest Selection and Steering Committee ASRM 2002 Member Abstract Review Committee ASRM 2002 Committee Chair Clinical Outreach Committee SSR

2 2001 Member Abstract Review Committee ASRM 2001 Chairman Clinical Outreach Committee SSR 1999 Committee Chair Clinical Outreach Committee SSR 1998 Member General Clinical Research Center Chairman Search 1997 Member Society of Reproductive Endocrinologists Nominating Committee ASRM 1995 Member Prize Poster Committee, Annual Meeting ASRM 1995 Member General Clinical Research Center Review Committee UNC

Editorial Positions:

2016 Reviewer, The Journal of Clinical Endocrinology & Metabolism 2016 Reviewer, BJOG: An International Journal of Obstetrics & Gynaecology 2016 Reviewer, Reproductive Sciences 2015 Reviewer, Journal of Obstetrics and Gynaecology 2015-2016 Reviewer, GHS Journal, Greenville Health System 2009-present Board of Reviewing Editors, Biology of Reproduction 2010 Ad hoc Reviewer ICER NICHD, NIH 2005 Reviewer – Special Emphasis Panel ZRG1 F06 NRSA Applications, NIH 2004–2007 Associate Editor, Human Reproduction 2000- Reviewer, National Science Foundation 2000- Ad hoc Reviewer, International Journal of Cancer 2000, 1997, 1996 Reviewer, Abstract Committee, SGI Annual Meeting 1997-2001 Editorial Board, Biology of Reproduction 1999-2002 Editorial Board, Journal of Reproductive Immunology 1995-2000 Reviewer, Reproductive Endocrine Study Section, NIH, Bethesda, MD 1999-2000 Reviewer, Well Being Foundation 1997 Reviewer, Abstract Committee, SSR Annual Meeting 1996 Reviewer, Abstract Committee, ASRM Annual Meeting Committee 1996- Ad hoc Reviewer, Endocrinology and J Clin Endocrinol Metab 1994- Ad hoc Reviewer, Obstetrics and Gynecology 1994- Reviewer, Journal of the Society for Gynecologic Investigation 1991- Ad hoc Reviewer, Fertility and Sterility

Intramural Grants/amount of awards:

2016-2018 Pfizer, Duavee IIR, “Hormone replacement after hysterectomy for endometriosis – An open label randomized comparison of conjugated equine estrogen (CEE) with CEE plus bazodoxiphene (Duavee)” 2011-2016 NIH R01-067721-01A1, B Lessey, Co-PI with Dr. Steven Young UNC; $3,500,000 in direct costs (funded 7/11) 2000-2003 NIH OD99-008 - Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) G. Orringer, PI; BA Lessey Program Director $2.5 Million 1997-09 NIH-U54, SCCPIR Dr. Frank French PI, Project Leader with Dr Steven Young / $600,000/year 1997-98 Schering AG - “Characterization of New Markers of Uterine Receptivity” / 80K in direct costs 1996-00 NIH U01 HD34824-01 - “Endometrial Integrins as Markers of Uterine Receptivity” / 409K in direct costs 1992-95 NIH R01 HD30476 - Endometriosis, Integrins and Infertility / 400K in direct costs 1992-97 NIH R29 HD29448 - Endometrial Integrins: A role in Uterine Receptivity / 262K in direct costs 1990-91 Biomedical Research Support Grant, University of Pennsylvania, Division of Research Resources, NIH 1989-90 American Cancer Center 1989-90 University of Pennsylvania Research Foundation 1986-87 Josiah C. Trent Foundation

3 Patents:

SIRT 1 Expression in Eutopic Endometrium as a Marker for Endometriosis and Subfertility US Patent: Provisional Patent Application filed on March 31, 2018 Inventors, Bruce A. Lessey, Steven L Young, and Jae-Wook Jeong BCL6 expression in eutopic endometrium as a marker for endometriosis and subfertility Publication number: WO2015143228 A1; Publication Date: Sep 24, 2015 Inventors: Steven L. Young, Bruce A. Lessey Leukocyte MicroRNAS for Use in Diagnosis and Treatment of Endometriosis Publication number: US 20150267257 A1; Publication date: Sep 24, 2015 Inventors: Mitzi Nagarkatti, Juhua Zhou, Bruce A. Lessey, Prakash Nagarkatti

Co-Principal Investigator:

2015-18 “Hormone Replacement After Hysterectomy for endometriosis” Pfizer Principal Investigator: Bruce A. Lessey, MD, PhD 2015-16 “Expanded Genetic Testing for Thrombophilias in Women with Recurrent Pregnancy Loss” Principal Investigator: Paul B. Miller, MD 2015 “BCL-6 in Endometrial Scratching before IVF” NIH Principal Investigator: Bruce A. Lessey, MD, PhD 1999-00 ACOG/Solvay Pharmaceuticals Research Award in Menopause: “Telomerase Expression and Regulation in Premenopausal and Post-menopausal Endometrium and Endometriosis”. Principal Investigator: Christopher D. Williams, MD 1999-00 “The Role of Age and Gonadal Dysgenesis on the Endometrium”. Principal Investigator: Christopher D. Williams, MD 1999-00 “Preeclampsia and Regulation of Placental Apoptosis”. Principal Investigator: Alexander D. Allaire. MD, MSPH 1998-99 ACOG/Cytyc Research Award for the Prevention of Cervical Cancer: “Telomerase and Cervical Cancer Risk” Principal Investigator: John F. Boggess, MD 1998-99 ACOG/Parke Davis Research Award to Advance the Management of Women’s Health Care: “Angiogenesis in the Female Reproductive Tract” Principal Investigator: Michael J. Murray, MD 1997-98 ACOG/Tambrands Clinical Research Fellowship Program in Menstrual Health “Polycystic Ovarian Syndrome (PCOS): A Mode To Study the Effects of Androgens on the Human Endometrium” Principal Investigator: Laurie P. Lovely 1997-01 NIH U54 HD35041 - “Molecular Regulation in Reproduction Principal Investigator: Frank S. French “Endometrial Integrins and Uterine Receptivity” / 669K in direct costs (shared with UNC) 1996-97 Society for Gynecologic Investigation - Mead Johnson Bristol-Myers Squibb Research Grant Principal Investigator: Steven L. Young 1996-97 NIH STTR Phase I/Adeza Biomedical Corporation, Small business sub-awarded grant “Uterine Receptivity Defects Testing Using Beta 3 Integrin” Principal Investigator: Nalini N. Murdter 1995-96 ACOG/Mead Johnson Bristol-Myer Squibb, Clinical Research Fellowship “Integrin Expression in Human Stromal Cells: A Model of Implantation and Endometrial Receptivity Principal Investigator: Lynda J. Wolf 1994-95 ACOG/Ciba Pharmaceutical Company - Fellowship for Research in Endometriosis of the Post-Menopausal Woman "Integrin Expression in Cultured Human Endometrial Epithelium: An In Vitro Study Characterizing Markers of Uterine Receptivity", Principal Investigator: Stephen Somkuti

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Clinical Studies:

2016 EP-002, “A Prospective Sample Collection Study in Patients with Pelvic Pain Undergoing Laparoscopy for Biomarker Identification in Endometriosis” Myriad Sponsored Study Protocol 2014 BAY 100-2670/15792, "A randomized, double-blind, double-dummy, parallel-group, multi-center Phase IIb study to assess the efficacy and safety of different doses of BAY 1002670 0.25 mg, 0.5 mg, 1 mg, 2 mg, or 4 mg per day orally versus active comparator (Miranova) and placebo in women with endometriosis over a 12-week treatment epoch." Initiated June, 2014 2011 9MZ-02-09MZ10-01; Abbott Sponsored Study Protocol. Completed 6/22/11 2011 M12-674 Abbott Sponsored Study Protocol “A Phase I, Open label study of the effects of Elagolix on ovarian activity, ovulation and ovarian reserve in adult premenopausal females – Initiated July, 2011 2011 Raloxifene vs. Clomiphene Citrate for Ovulation Induction and Pregnancy in PCOS Women, Departmental funding

Awards, Honors, Membership in Honorary Societies:

2016 ASRM Star Award 2015 Alpha Omega Alpha Honor Medical Society – Founding Member, USC SOM Greenville Chapter 1984 Alpha Omega Alpha Honor Medical Society 2015 Best Doctors in America 2015 2015 ASRM Star Award 2014 Best Poster, ASRM - 2nd place 2013 2013 ASRM Star Award 2013 Best Doctors in America 2013 SGI New Investigator Poster Award (Emily Evans-Hoeker) 2012 2012 ASRM Star Award 2012 Department OBGYN CREOG Teaching Award June 2012 2011 Excellence in REI Mentorship, Society for Reproductive Endocrinology and Infertility, ASRM Annual Meeting 2005-2012 Best Doctors in America Award (selected by peers) 2011 Best Poster, Society Gynecologic Investigation, Miami, FL (Joshi) 2009 Donald F. Richardson Prize Paper Award, ACOG, Chicago, IL (Sharai Amaya) 2008 Best Clinical Research Paper 1st prize Carolina Women’s Health Research Forum (Lauren Nelson) 2008 1st prize at ACOG District IV (Sharai Amaya) 2008 1st prize at SCOBGYN Society (Sharai Amaya) 2008 GHS Outstanding Resident Research Project, Easley Symposium (Sharai Amaya) 2007 Thomas A. and Shirley W. Roe Foundation Award for “Best paper by a practicing physician” 2007 GHS Outstanding Faculty Research Award 2007 1st Prize at SC OBGyn Society (Nancy Collins) 2007 2nd Prize at SC OBGyn Society (Brent Parnell) 2007 Best Clinical Sciences Prize Carolina Women’s Health Research Forum (Alberto Palomino) 2007 1st Prize Presentation Easley Symposium, Best Project (Nancy Collins) 2006-07 America’s Top Obstetricians and Gynecologists Award, Consumers Research Counsel of America, America’s Top Obstetricians and Gynecologists 2006 Citation Classics in Fertility and Sterility 1975-2004, Fertility and Sterility 2006 2005 Donald F. Richardson Prize Paper Award, ACOG, Washington, DC (Shannon McLaughlin) 2005 Prize Presentation SC OBGYN Society, 2nd Place (Brandi Alt) 2004 ACOG Junior Fellows Finalist Award, San Francisco, CA 2004 South Carolina OBGYN Resident Presentation Award, 2nd Place, Charleston, SC 2004 Donald F. Richardson Prize Paper Award, ACOG, San Francisco, CA (William Merritt) 2003 Best Doctors Award, Junior Fellows Presentation Award, First Place ACOG District IV meeting, Savannah, GA 2002 SREI Fellowship Research Prize Paper Award 2001 Life Member, National Registry of Who's Who 2000 Good Housekeeping: The Best Doctors for Women Distinguished Alumnus Award, Department of Biology, University of Delaware 1996 President’s Presenter Award (Lingwen Yuan, PhD), SGI Annual Meeting, Philadelphia, PA 1991 Berlex Foundation Scholar Award

5 1989 American Fertility Society-Ortho Distinguished Fellowship in Reproduction 1989 President's Award, Society of Gynecologic Surgeons 1986-88 Carter Society Research Award, Duke University Medical Center - District IV Research Award 1984 Colorado Obstetrical & Gynecological Award 1983-84 Joseph & Regina Glaser Research Award, University of Colorado 1983 Alpha Omega Alpha 1982 Student Honors and Research Committee Award, University of Colorado School of Medicine 1981-82 ARCS Foundation Scholarship for Medical Research 1980 Cited for Academic Excellence, University of Colorado School of Medicine

Academic Committee Activities (past 5 years):

2015-present Research Committee, Department of OBGYN, Greenville Health System 2009-present Physician Advisory Council, Greenville Hospital System University Medical Center 2007-present Academy of Distinguished Educators, Greenville Hospital System University Medical Center

Major Teaching Responsibilities:

2003- Present 3rd Year Medical School Curriculum (every 8 weeks) with lectures on Menopause and on Endometriosis 2003-Present 4th Year Medical School Curriculum and Elective 2003-Present Resident lectures (menopause, PCOS, steroid receptors, endometriosis, cardiovascular disease in women)

Undergraduate Medical Education:

2008- Present Clemson research elective for 3rd or 4th year bioscience students Ryanne Dodds Ashley Graham Greta Bushnell Anna Moorhead Katherine Amalfitano Nicholas Tallman Callie Vogler Carter Williams Ashley Aikens Hilary McGrath Tori Wilson

Graduate Medical Education:

Postdoctoral Research Fellows: Abiodun Ilesanmi, M.D. Lagos, Nigeria Arthur Castelbaum, M.D. University of Pennsylvania Lei Ying, M.D. Stony Brook, SUNY Steve Somkuti, Ph.D., M.D. Duke University Medical Center Lynda J. Wolf, M.D. University of Michigan Medical Center Steven L. Young, Ph.D., M.D. Yale University Lingwen Yuan, Ph.D. Hershey Medical Center Laurie P. Lovely, M.D. Emory University School of Medicine Yaoting Gui, Ph.D. Ton & JI Medical University, Wuhan, China K B C Appa Rao Deemed University, Indian Veterinary Research Institute, Izatnagar, India Michael J. Murray University of Oregon School of Medicine Christopher Williams University of Virginia School of Medicine Rebecca Usadi Duke University School of Medicine Wilder A. Palomino Santiago, Chile Ricardo Savaris Port Alegra, Brazil

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BIRCWH Scholars: Kim Boggess, M.D. University of Washington School of Medicine Kimberly A. Brownley, Ph.D. University of North Carolina Elizabeth Claire Dees, M.D. Duke University Medical Center Katherine E. Hartmann M.D., Ph.D. Johns Hopkins University School of Medicine Department of Epidemiology, University of North Carolina Angela D.M. Kashuba Pharm.D. State University of New York at Buffalo, Amherst, NY Ruth A. Lininger, M.D. M.P.H University of North Carolina, School of Medicine and School of Public Health

Graduate Students: Julia T. Arnold “Human Endometrial Stromal Cells Regulate Epithelial Cell Growth and Function In Vitro”. The University of North Carolina, 1998

Major Clinical Interests and Responsibilities: 2003- 2011 Director, Reproductive Endocrinology Division 2005 to 2010: Donor Egg Program Director

Major interests are in the areas of infertility, endometriosis, implantation disorders, polycystic ovary syndrome, especially related to endometrium and steroid receptor biology. Involved in clinical research involving recurrent pregnancy loss and surgical interventions that relate to endometriosis, infertility and chronic pelvic pain. Participate in IVF-ET program every 4th week as attending.

Lectures/Presentations: Invited lectures and presentations:

2016 Optimizing Endometrial Receptivity, Chair - Interactive Symposium, American Society for Reproductive Medicine Annual Meeting, Salt Lake City, UT October 15 – 19, 2016

PCOS – Overview and Genetic Risks, StartART, Las Vegas, NV August 4 – 5, 2016

Endometriosis – Update on Diagnosis and Treatment, StartART, Las Vegas, NV August 4 – 5, 2016

Endometriosis and Progesterone Resistance, Resident & Fellow Research Day Guest Lecturer, Wake Forest University School of Medicine, Winston-Salem NC, June 6, 2016

2015 Misconceptions for the Diagnosis and Treatment of Endometriosis, Department of OB-GYN Grand Rounds Lecturer, Greenville Health System, Greenville, SC, November 20, 2015

Advances in Endometriosis, Grand Rounds Guest Lecturer, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil, December 3, 2015

Polycystic Ovary Syndrome: Clinical Implications, Resident/Student Guest Lecturer, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, December 2, 2015

Endometriosis in the Infertile Patient, Interactive Session, ASRM 2015, Baltimore, MD October 19, 2015

Misconceptions in Endometriosis: Diagnosis and Treatments, Grand Rounds Guest Lecturer, OB-GYN Series, UNC, Chapel Hill, NC, October 7, 2015

Optimal Management of PCOS, StartART, Las Vegas, NV August 6 – 7, 2015

Endometriosis: Misconceptions & Treatment Strategies, StartART, Las Vegas, NV August 6 – 7, 2015

Estrogen Dominance and Progesterone Resistance in Endometriosis and Infertility, Women’s Health Advisory Board, Session IV: Endometrial Actions of TSECs/ER Ligands, Clearwater, FL, April 26-28, 2015

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2014 Long-Term Management of Endometriosis, Improved and Individualized Approaches, Honolulu, HI October 20, 2014

Optimal Management of PCOS. START ART, Session IV - ART Innovations & Interventions, Las Vegas, NV 8/7/14

Endometriosis: Misconceptions & Treatment Strategies. START ART, Session IV – ART Innovations & Interventions, Las Vegas, NV 8/7/14

Root Causes and Consequences of Endometriosis and Progesterone Resistance. Society for the Study of Reproduction, Session E. Humans/Nonhuman Primate Models 2 (SGI Exchange), Grand Rapids, MI 7/21/14

Endometriosis: An Inflammatory Condition Causing Infertility and Pain, Hospital de Clínicas de Porto Alegre, Dept OBGYN, Porto Alegra, Brazil, 5/5/14

Endometriosis, Inflammation and Progesterone Resistance. Triangle Consortium of Reproductive Biology, 2014 NIEHS, Research Triangle, NC

Infertility, Inflammation and Progesterone Resistance, Center for Reproductive Medicine at Baylor College of Medicine, Houston, Texas, April 14, 2014

2013 Endometriosis: What every doctor should know. OBGYN Grand Rounds, Department of Obstetrics and Gynecology, Greenville, SC 12/13/13

Pathophysiology of Endometriosis-related Infertility, American Society for Reproductive Medicine, Boston, MA 10/13/13

Medical Management of Endometriosis and Infertility, American Society for Reproductive Medicine, Boston, MA 10/13/13

Is Endometriosis One or Several Diseases? American Society for Reproductive Medicine, Boston, MA 10/13/13

The Endometrium in Health and Disease, Texas Tech University Health Sciences Center, Odessa, TX, 9/11/13

Endometriosis? What Every Doctor Should Know, Texas Tech University Health Sciences Center, Odessa, TX, 9/11/13

Pathophysiology of Endometriosis, 4th Nordic Congress on Endometriosis, Turku, Finland, 5/24/13

Unexplained Infertility and Pregnancy Loss as a Continuum of Endometrial Dysfunction, SGI 60th Annual Scientific Meeting, NICHD Satellite Meeting, Orlando, FL, 3/20/13

Infertility and Progesterone Resistance, SGI 60th Annual Scientific Meeting, Endometrial Satellite Symposium, Orlando, FL, 3/20/13

2012 Endometriosis, Progesterone Resistance and Inflammation: A Preventable Cause of IVF Failure, Melbourne, Australia, 11/29/12

Endometriosis, Infertility and Progesterone Resistance: Ontogeny and Resolution, Australian Health and Medical Research Congress, Society of Reproductive Biology Endometriosis Symposium, Adelaide, Australia, 11/26/12

Endometrial Receptivity and Infertility: Beyond Integrins, Philadelphia Area Reproductive Endocrine Society, Philadelphia, PA 9/20/12

Biomarkers and Endometrial Receptivity: What’s New in 2012, CFAS, Ottawa, Canada 9/8/12

Endometriosis, Pain and Infertility: New Insights into an Old Disease, Dept OBGYN, Queens University, Kingston, ON Canada 9/6/12

Endometriosis: Pain and Infertility, Southern Obstetric and Gynecologic Seminar, Asheville, NC 7/20/12

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Infertility Work-Up for the Generalist, Southern Obstetric and Gynecologic Seminar, Asheville, NC 7/20/12

Endometriosis, ACOOG, Tucson, AZ, 3/11-15/12

2011 Endometrial Receptivity and Endometriosis - ESHRE Campus 2011, Rome, Italy, 10/28-29/11

A New Paradigm for Understanding Pain and Infertility in Women with Mild Endometriosis, Pelvic Pain and Sterility: New Frontiers for the Treatments of Endometriosis, Biorama Institute, Ara Pacis Museum, Rome, Italy, 10/28/11

New Directions in Pain and Infertility in Minimal and Mild Endometriosis, Grand Rapids, MI 4/13/11

2010 Clinical Translation: IVF, Endometriosis and Pregnancy Outcomes; The Maternal Embryo Interface ESHRE Valencia, Spain 12/2-3/2010

Cardiovascular Disease in Women; Grand Rounds, Dept. OBGYN, Greenville Hospital System 11/19/10

Natural Progesterone Resistance: Evidence from Full Thickness Normal and Abnormal Endometrium; Gordon Research Conference on Reproductive Tract Biology, Andover, NH, 8/16-20/10

Endometriosis: What Should the OBGYN Know Today – Presented to Medical Center of Central Georgia, Macon, GA 6/10

Implantation Physiology: Understanding the Key to Success, New England Fertility Society meeting, Newport RI 5/1

In Vitro Fertilization, ART and PGD, Greenwood Genetic Center Graduate Course, Greenville SC, 1/10

2009 Assessment and Regulation of Endometrial Receptivity,’ 15th World Congress on IVF, Geneva, Switzerland

Endometriosis and Infertility: Diagnosis and Management, Grand Rounds, Greenville Hospital System, 10/2009

Molecular Regulation of Implantation: Why Progesterone is So Important, Baylor College of Medicine, Houston, TX

Understanding Infertility and Defects in Implantation in the Age of Genomics, Louis L. Friedman Lecture in Reproductive Endocrinology, Obstetrics, Gynecology & Women’s Health: 38th Annual Autumn Seminar, University of Minnesota, Minneapolis, MN

Carolina Woman’s Health Research Forum, Russell House, Univ. of South Carolina, Columbia, SC

Tissue Bank, Roundtable Discussion, ASRM, Washington, DC

Anovulation, IR, and the Endometrium: A Focus on Current or Future Implantation and Pregnancy Loss, Polycystic Ovary Syndrome (PCOS) and Insulin Resistance: Strategies for Treating and Healing” Conference, Asheville, NC

2006 New Insights into Uterine Receptivity: Embryo Implantation, ACOG District IV Mtg. - Palm Beach, FL Improving Implantation: Choosing the Right Embryo and Ensuring a Receptive Endometrium, ASRM Annual Mtg, New Orleans, LA

PCOS: A Model for Endometrial Dysfunction Endometrial Physiology & Pathology, Serono Symposia, San Francisco, CA Uterine Receptivity & Implantation: Making Sense of it All, Grand Rounds, Wayne State University, Detroit, MI

2005 Markers of Endometrial Receptivity, University of Cincinnati Dept. of OBGYN, Cleveland, OH

Non-traditional Markers of Endometrial Receptivity: Are they Ready for the Clinic?, Serono Symposia, Miami, Florida

Estrogen Receptors and Defects in Uterine Receptivity, UMASS Medical School, Department of Physiology

Estrogen Receptors and Uterine Receptivity, A Symposium Honoring the Retirement of Robert Brenner, Portland, OR

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Biomarkers of Uterine Receptivity: Where Have We Come From and Where are We Going?, SC OB/GYN Society Annual Mtg.Charleston, SC

Valeo Medical Symposium – Moving from Discovery to Validation with a Noninvasive Diagnostic for Endometriosis, IX World Congress on Endometriosis, Maastricht, Netherlands

Markers in Endometriosis: New Perspectives and Directions, Cyr61 expression in normal and abnormal endometrium, ACOG District IV Mtg., Cabos, San Lucas, Mexico

2004 Endometrium and Implantation, Cleveland OBGYN Society Meeting, Cleveland, OH

Endometrial Receptivity and Implantation: An Interface between Science and Clinical Medicine, Distinguished Lecture Series, Clemson University

Estrogen receptors and Endometrial Receptivity, University of Pennsylvania, Philadelphia, PA

Endometrial Function and Implantation, Hartford Hospital, Dept. OBGYN, Grand Rounds, Hartford, CT

2003 Polycystic Ovarian Syndrome and Uterine Receptivity Defects, SCCPRR Directors Mtg., NICHD, NIH, Bethesda, MD

Embryo-Endometrial Interactions & Infertility, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Endometriosis and the Endometrium: Much Left to Learn, Society for the Study of Reproduction, Annual Mtg., Cincinnati, OH

Endometrial Receptivity and Implantation, Canadian Fertility and Andrology Society, Victoria, British Columbia

Endometrial Responsiveness to Ovarian Steroids: A Moving Target, Reproduction 2003, NICHD, NIH Symposium, Bethesda, MD

2002 Sex Steroids and Endometrial Receptivity, Keynote Speaker; 4th Annual Northwest Reproductive Sciences Symposium, Oregon National Primate Center, Portland, OR

Two pathways of progesterone action on the endometrium, 2nd International Symposium on Progestins, Progesterone receptor Modulators and Progesterone Antagonists, Siena, Italy

2001 Osteopontin and αvβ3 Integrin: Biomarkers to study the regulation of uterine receptivity. Department of Pathology, University of NC

Insulin Resistance, Polycystic Ovarian Syndrome and Poor Reproductive Outcome are related to Defects in Endometrial Receptivity? Department of OBGYN, Grand Rounds, University of Colorado Health Science Center

Osteopontin and its Integrin Receptor are Co-expressed but Differentially Regulated in Human Endometrium, University of Colorado Health Science Center, Endocrine Division Research Conference, Denver CO

Expression of genes relevant to implantation in women with endometriosis and infertility, Endometriosis: Emerging Research and Intervention Strategies, NIH Workshop, Cell Adhesion Molecules and Implantation, 2nd International Workshop on Human Implantation, Madrid, Spain

New Insights on Integrins and Implantation, 6th International Conference on the Extracellular Matrix of the Female Reproductive Tract, Bethesda, MD

Uterine Fibroids: Environmental and Hormonal Factors, NIEHS Leadership Retreat, Wake Forest University, Wake Forest, NC

Insights on a Successful Career, University of Delaware Commencement Address, Department of Biology, University of Delaware, Newark, DE

Embryo Implantation: Choosing a Research Career that will last a Lifetime, David G. Hall Symposium, Department of

10 Obstetrics and Gynecology, University of Missouri-Columbia School of Medicine, Columbia, MO Endometrial Receptivity, Frontiers in Reproduction, Marine Biological Laboratory, Woods Hole, MA

Endometrial Receptivity: Differential Expression of Glycoproteins on the Surface Epithelium in Fertile and Infertile Women, ASRM/SREI Exchange Session, Emerging Concepts in Embryo Implantation, ESHRE, Switzerland

2000 Endometrial Receptivity, Organon Experts in Reproductive Medicine Meeting, St. Thomas, USVI , Does Polycystic Ovarian Syndrome Cause a Deficit in Uterine Receptivity?, University of Virginia Department of Medicine and Cell Biology, Charlottesville, VA

Endometrial 3 Integrin Subunit Gene Expression Is Mediated by SP1 slide presentation, 47th Annual SGI Mtg., Chicago, IL

Markers of Endometrial Receptivity, International Symposium on ART and the Human Blastocyst, Dana Point, CA

Uterine Receptivity and Non-Receptivity, Investigative Pathology Seminar, Department of Pathology, Vanderbilt University, Nashville, TN

XVI FIGO World Congress of Gynecology and Obstetrics. Speaker on Uterine Receptivity – Implantation, Washington, DC

Endometrial receptivity in IVF, Roundtable Conference sponsored by Organon, Lisbon, Portugal

Recent Advances in Infertility, Wake AHEC, Maria Parham Hospital, NC

International Symposium on Cell and Molecular Biology of Endometrium in Health and Disease, Oxford-Kobe Seminar, Kobe, Japan

1999 Blastocyst Development and Early Implantation Workshop, University of Lund/Trolleholm Castle, Sweden Endometrium: Endocrine Target & Paracrine Tissue, Speaker Session – Chair, The ENDO ´99 81st Annual Meeting, San Diego, CA

The Effect of Hydrosalpinges on Uterine Receptivity, Main Program, Annual Mtg. of the ESHRE, Tours, France

1998 Infertility Endometrial Markers of Uterine Receptivity Defects in Implantation, Triangle Area Endometriosis Association Support Group, Research Triangle Park, NC

Integrins as Markers of Uterine Receptivity, Piedmont OB/GYN Society Meeting, Piedmont SC

Role of Endometrial Integrins In Placental Invasion, Celebrating 20 Years of ART: From Cells and Techniques to Molecules and Innovation, MEC, Chicago, IL

Endometrial Integrins as a Diagnostic Tool for Infertility, International Symposium on Reproductive Medicine, ASRM-ESHRE- IVI, Madrid, Spain

Markers of Uterine Receptivity and Occult Defects in the Window of Implantation, Frontiers In Reproduction Research Symposium, NICHD, Woods Hole, MA

Integrins - What Do They Tell Us About Hydrosalpinx, Endometriosis, and Unexplained Infertility?, 11th Annual In Vitro Fertilization and Embryo Transfer, Santa Barbara, CA

New Concepts on Implantation, 20 Years from ART to Start: Current Concepts for Nurses in Reproductive Medicine, Buena Vista, FL

GnRHa Treatment for Infertility and Endometriosis, OB/GYN Grand Rounds, University of Texas Medical Center, Galveston, TX and University of Texas Health Science Center, San Antonio, TX

Markers of Uterine Receptivity: New Insights into Implantation Defects, Endocrine Noon Conference, University of Texas Medical Center, Galveston, TX

11 Estudio de las integrinas como metodo diagnostico en infertilidad, Simposio Internacional: Implantacion Embrionaria y Aboroto Recurente, Red lationamericana de Reproduccion Asistida y Sociedad, Argentina

1997 Integrins as Mediators of Cell Signaling in the Female Reproductive Tract, Keynote speaker: Physiology of Reproduction Mini Symposium, Department of Animal Sciences, Texas A&M, College Station, Texas

Cell Adhesion Molecules in Implantation, Scripps Research Institute, La Jolla, CA

Molecular Basis of Implantation and its Clinical Perspectives, 70th ICCR Conference, Special Invited Lecture, The Population Council, New York, NY

Regulation of Implantation: Insights through the Study of Integrins, Wyeth Ayerst, Women’s Health Research Institute, Philadelphia, PA

Diagnosis and Treatment of Infertility Due to Endometriosis and Integrins, Management of the Patient with Endometriosis or Uterine Fibroids, Medical Education Collaborative, Boston, MA

Integrins and Uterine Receptivity: Clinical Correlates, The Richard K. Miller Lecture, University of Rochester, Department of Ob-Gyn, Rochester, NY

Integrins in Reproduction, Paracrine Mechanisms Symposium, The Ares-Serno Foundation, Seville, Spain

Integrins and the Implantation Window, 4th Bourn Hall Meeting, The Ares-Serno Foundation, Cambridge, England

Hormonal and Paracrine Effectors of Endometrial Integrin Expression: Implications for the Window of Implantation, Society for the Study of Reproduction Thirtieth Annual Mtg., Portland, Oregon

Rol de las Integrinas en la Implantacion Embrionaria, and Esterilidad de Causa No Precisida. La Importancia de la Evaluacion Molecular del Endometrio, Avances En Reproduccion Humana, Universidad de Chile, Santiago, Chile s.a.

Implantation and Cell Adhesion Molecules, First International Conference on Experimental and Clinical Reproductive Immunobiology, Charlottesville, VA

Integrins and Uterine Receptivity, Molecular and Cellular Aspects of Preimplantation Processes, Serono Foundation, Newport Beach, CA

Integrins as Markers of Uterine Receptivity - Implications for Infertility and Assisted Reproductive Technology, Grand Rounds, Eastern Virginia Medical School, Norfolk, VA

Diagnosis and Treatment of Infertility Due to Endometriosis, Medical Education Collaborative, New Orleans, LA

The Challenges of Finding a Suitable Marker of Uterine Receptivity Toward Embryo Implantation, P.A.R.S., Philadelphia, PA

Markers of Uterine Receptivity: Past, Present, and Future, Grand Rounds Allegheny Women’s Hospital, Philadelphia, PA

1996 Integrins, Cadherins, and Immunoglobulins, Moderator, Society of Gynecologic Investigation, Philadelphia, Pennsylvania (3/96)

Endometriosis, Lenox Hill Hospital, New York, NY Grand Rounds, University of Louisville, Louisville, Kentucky

Integrins: Markers of Uterine Receptivity Defects in Endometriosis, Grand Rounds, University of Missouri, Columbia, Missouri

Integrins and the Detection of Occult Defects in Uterine Receptivity, Conference on Human Uterine Receptivity for Blastocyst Implantation, National Institutes of Health, Bethesda, Maryland

Endocrine and Paracrine Regulation of Uterine Receptivity: Lessons Learned from the Study of Endometrial Integrins, Symposium on Cellular Endocrinology, W. Alton Jones Cell Science Center, Inc., Lake Placid, New York

12 Hormonal Regulation of Uterine Receptivity: Lessons From Endometrial Integrins Research, Conference: “Reproduction et Endometre”, Organon Laboratories, Paris, France

Occult Defects: Lessons Learned from Integrin Research, International Conference on The Uterus: Endometrium and Myometrium, NYU School of Medicine, Department of OB/GYN, New York, New York

Assisted Reproduction and its Effect on Endometrial Receptivity, Carter Society Mtg., Baltimore, Maryland

Regulation of Endometrial Integrins: Implications for the Diagnosis and Treatment of Endometriosis, World Congress on Endometriosis, Yokohama, Japan

1995 lntegrins and Implantation, Grand Rounds, Stony Brook Health Sciences Center, Stony Brook, NY

Minimal Endometriosis and It Impact on Fertility-New Insights Using Markers of Endometrial Receptivity, Endometriosis 2000 Conference, National Institutes of Health, Bethesda, MD

Integrin Expression in Human Endometrium in Fertile and Infertile Women, Sixth International Congress of Reproductive Immunology, Washington, D.C.

Integrins as Markers of Endometrial Receptivity, Grand Rounds, Carolinas Medical Center, Charlotte, NC

Clinical Significance of Integrin Cell Adhesion Molecules as Markers of Endometrial Receptivity" Schering Foundation, Berlin, Germany

1994 Endometrial Integrins and Embryonic Implantation, SCRIPPS Research Institute, La Jolla, CA

Endometriosis and Unexplained Infertility, North Carolina OB/GYN Society Mtg., Pinehurst, NC

Integrins and Infertility, Alternatives to Hysterectomy--Bench to Bedside Mtg., NICHHD, Bethesda, MD

Integrins as Markers of Endometrial Receptivity, Round Table Discussion, FC/HT-Research, Schering AG, Berlin, Germany

Post-Fertilization to Implantation - Integrin Biology, Institute of Medicine, National Academy of Sciences, Workshop on Contraceptive Research and Development and the Frontiers of Contemporary Science, Washington, DC

1993 Integrins and Uterine Receptivity: Implications for Fertility and Infertility, The Society of the Study of Reproduction Workshop: Uterine Biology/Implantation, Ft. Collins, CO

Endometrial Integrins: A Role in Fertility and Infertility, Grand Rounds at Indiana University, Indianapolis, IN

1992 Endometrial Integrins and Uterine Receptivity, The Berlex Foundation Annual Awards Dinner, San Antonio, TX

Integrins in Normal and Abnormal Endometrium, Carter Society Annual Meeting, Charleston, SC

1991 Menopause: Insights onto Management, Symposia sponsored by the University of Pennsylvania, Philadelphia PA

Submitted presentations:

Taylor HS, Giudice LC, Lessey BA, Abrao M, Kotarski J, Williams LA, Rowan JP, Chwalisz K, Duan WR, Schwefel B, Thomas JW, Jain RI. Elagolix, an oral gonadotropin-releasing hormone antagonist, for the management of endometriosis-associated pain: safety and efficacy results from two double-blind, randomized, placebo-controlled studies. (P-440) American Society for Reproductive Medicine 2016 Annual Meeting, Salt Lake City, UT, October 15 – 19, 2016

Diamond MP, Simon J, Lessey BA, Taylor HS, Rowan JP, Chwalisz K, Schwefel B, Thomas JW, Jain RH, Williams LA. The Effect of Elagolix On The Endometrium: Safety Results From Two Randomized, Placebo-Controlled Studies in Women With Endometriosis- Associated Pain. (O-232) American Society for Reproductive Medicine 2016 Annual Meeting, Salt Lake City, UT, October 15 – 19, 2016

13 Hoff HS, Yuan L, Lessey BA, Young SL. Complex Differential Expression Of Colony Stimulating Factor (Csf) Ligands And Receptors In The Human Endometrium. (0-25) American Society for Reproductive Medicine 2016 Annual Meeting, Salt Lake City, UT, October 15 – 19, 2016

Fox CW, Young SL, Jeong J, Palomino WA, Lessey BA. BCL6 and Sirt1 Expression in Unexplained Infertility Versus Unexplained, Recurrent Pregnancy Loss. (P-299) American Society for Reproductive Medicine 2016 Annual Meeting, Salt Lake City, UT, October 15 – 19, 2016

Surrey E, Giudice LC, Lessey BA, Taylor HS, Williams LA, Rowan JP, Chwalisz K, Schwefel B, Thomas JW, Jain RI. Use of Elagolix For The Management of Endometriosis-Associated Pain: Secondary Efficacy Results From Two Randomized, Placebo-Controlled Studies. (P-434) American Society for Reproductive Medicine 2016 Annual Meeting, Salt Lake City, UT, October 15 – 19, 2016

Savaris, R, da Silva, DM, Gross, L., Lessey, BA. The Use of Resveratrol For Pain In Endometriosis – A Randomized Clinical Trial. 32nd Annual Meeting of ESHRE, Helsinki, Finland, 3 July – 6 July, 2016

Young, SL, Jeong, JW, Schammel, DP, Lessey, BA. Endometrial B-cell lymphoma 6 (BCL6) and Sirtuin 1 (SIRT1) Immunostaining are prognostic factors for implantation failure in the setting of ART. 32nd Annual Meeting of ESHRE, Helsinki, Finland, 3 July – 6 July, 2016

Lessey, BA, Jung-Yoon Yoo, Tae Hoon Kim, Asgerally T. Fazleabas, Steven L. Young, Jae-Wook Jeong. Over-expression of endometrial SIRT1/BCL6 and progesterone resistance in women with endometriosis and infertility. LB Fri-08 98th Endocrine Society Meeting, Boston MA, March 30-April 1, 2016.

Hoff, H, Jung-Yoon Y, Jeong JW, Yuan L, Lessey, BA, Young SL. Expression of the Endometrial Indian Hedgehog (IHH) Mediator Gli1 is Suppressed by BCL6. (O-079) Society for Reproductive Investigation 63rd Annual Scientific Meeting, Montreal, QC, Canada, March 13– 16, 2016

Strug M, Su R, Lessey BA, Young S, Jeong JW, Fazleabas, A. The Notch Family Transcription Factor RBP-Jĸ is Reduced in Recurrent Pregnancy Loss (RPL) and Mediates Postpartum Endometrial Repair. (O-119) Society for Reproductive Investigation 63rd Annual Scientific Meeting, Montreal, QC, Canada, March 13– 16, 2016

Ahn SH, Khalaj KK, Young SL, Lessey BA, Tayade D, Koti M. Unique Expression of Immune-Related Genes in Women with Endometriosis. (T-232) Society for Reproductive Investigation 63rdAnnual Scientific Meeting, Montreal, QC, Canada, March 13– 16, 2016

Joshi N, Strakova A, Yoo JY, Lessey BA, Young S, Jeong JW, Fazleabas A. Altered Hippo Signaling Pathway in Baboon and Women with Endometriosis. (S-192) Society for Reproductive Investigation 63rdAnnual Scientific Meeting, Montreal, QC, Canada, March 13– 16, 2016

Monsanto SP, Miller J, Ahn SH, Young SL, Lessey BA, Tayade C. Evaluation of IL-33 in the Pathogenesis of Endometriosis. (S-224) Society for Reproductive Investigation 63rdAnnual Scientific Meeting, Montreal, QC, Canada, March 13– 16, 2016

Slizewski D, Crowe R, Young SL, Lessey, BA. Endometriosis is a Common Denominator in Unexplained Pregnancy Loss and Infertilty Based on BCL6 Testing. ASRM, Baltimore, MD, October 21, 2015

Joshi N, Sharma P, Bond S, Jeong J, Young S, Lessey B, Fazleabas AT.The TranscriptionalRepressor BCL6 is a Diagnostic Biomarker for Endometriosis and Related Infertility. Society of Endometrium and Uterine Disorders Congress 2015, Endometriosis Research Session. Paris, France, May 9, 2015

Lessey, BA, Jeong, J, Yoo, J, Fazleabas, A, Young, S. Silent Mating Type Information Regulation 1 (Sirtuin-1; SIRT1) is Over-expressed in Eutopic Endometrium of Endometriosis, Society for Reproductive Investigation 62nd Annual Meeting, San Francisco, CA March 25 – 28, 2015

Miller PB, O’Donnell LM, Likes CE, Forstein DA, Roudebush WE, Lessey BA. Short-term Benefits of Endometrial Biopsy are Similar to Diagnostic Laparoscopy for Unexplained Infertility. Society for Reproductive Investigation 62nd Annual Meeting, San Francisco, CA March 25 – 28, 2015

Likes CE, Crowe RC, Lessey BA, Forstein DA, Miller PB, Roudebush WE. Increased Rate of Oocyte Loss in PCOS Patients Correspondence to Diminished Fecundity Compared to Non-PCOS Patients. Society for Reproductive Investigation 62nd Annual Meeting,

14 San Francisco, CA March 25 – 28, 2015

Young SL, Evans-Hoecker EA, Jeong J, Yoo Y, Savaris R, Lessey, BA. B-Cell Lymphoma Protein 6 (BCL-6): A Novel Diagnostic Marker for Endometriosis. American Society for Reproductive Medicine 2014 Annual Meeting, Honolulu, Hawaii. Oral Session: Endometriosis I, October 20, 2014

Gentry AL, Evans-Hoecker E, Lessey BA, Yuan L, Young SL. Does the Endometrium Synthesize Progesterone? American Society for Reproductive Medicine 2014 Annual Meeting, Honolulu, Hawaii. Poster Session: Endometrium, October 22, 2014

AT, Young SL, Tayade C. Protein Inhibitor of Activated Stat-3 (PIAS-3) is Down-Regulated in Eutopic Endometrium of Infertile Women with Endometriosis by Stromal-Derived CXCL10 (IP-10). American Society for Reproductive Medicine 2014 Annual Meeting, Honolulu, Hawaii. Poster Session: Endometrium, October 22, 2014

Roudebush WE, Williams SE, Forstein DA, Lessey BA, Likes CE, Miller PB. Predicting Implantation Potential Using Morphometric Analysis of Blastocycsts and Calculating for PHI to Determine a Reference Point. American Society for Reproductive Medicine 2014 Annual Meeting, Honolulu, Hawaii. Poster Session: Art – Clinical, October 22, 2014

Lessey BA, Jeong JW, Yoo JY, Langenheim JF, Fazleabas A. Down Regulation of microRNA(miR)-451 and Increased Expression of YWHAZ Contributes to the Pathophysiology of Endometriosis in Both Women and Baboons. Society for the Study of Reproduction 2014, Grand Rapids, Michigan July 19 – July 23, 2014

Ah Ji Yeon, Ahn Jong, Fazleabas A, Jeong J, Kim T, Kim Y, Lessey, B, Lim J, Yoo J, Young S. Dysregulation of cAMP-Response Element-Binding 3-like protein 1 (CREB3L1) in Eutopic Endometrium of Women with Endometriosis. Society for the Study of Reproduction 2014, Grand Rapids, Michigan July 19 – July 23, 2014

Tayade C, Ahn SH, Edwards A, Reifel C, Young SL, Lessey BA. Interleukin17A Expression in the Plasma and Endometriotic Tissue from Women with Endometriosis, 12th World Congress on Endometriosis, Sau Paulo, Brazil April 30 – May 3, 2014

Fazleabas AT, Lessey BA, Savaris R, Young, SL, The Origins of Progesterone Resistance in Endometriosis: Silencing of Progesterone Action at Menstruation, 12th World Congress on Endometriosis, Sau Paulo, Brazil April 30 – May 3, 2014

Fazleabas A, Su R-W, Jeong J-W, Lim JM, Young SL, Lessey BA. Decrease in Notch 1 Contributes to Impaired Decidualization Associated with Endometriosis. 12th World Congress on Endometriosis, Sau Paulo, Brazil April 30 – May 3, 2014

Young, SL, Mese TB, Canno GO, Langenheim J, and Lessey BA. Receptor Switching in Endometriosis May Convert Anti-Inflammatory Signaling Into Pro-Inflammatory Signaling. 61st Annual Meeting of the Society for Gynecologic Investigation, Florence, Italy, March 26-29, 2014

Crawford NM, Mesen TB, Yuan L, Lessey BA, Milne G, Canno GO, Young SL. Lipoxin A4 and Resolvin D1 Production by an Endometrial Epithelial Cell Line. 61st Annual Meeting of the Society for Gynecologic Investigation, Florence, Italy, March 26-29, 2014

Lessey BA, Langenheim J, Young SL. Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Expression is Increased in Eutopic Endometrium of Women with Endometriosis. 61st Annual Meeting of the Society for Gynecologic Investigation, Florence, Italy, March 26-29, 2014

Young SL, Mesen T, Canny GO, Lessey BA; Lipoxin A4: Pro-versus anti-inflammatory response to Lipoxin A4 may depend on receptor switching in endometriosis. 61st Annual Meeting of the Society for Gynecologic Investigation, Florence, Italy, March 26-29, 2014

Crawford NM, Mesen TB, Lingwen Y, Lessey BA, Milne GL, Canny GO, Young SL. Endometrial Epithelial Cell Production of Lipoxin A4 and Resolving D1.Triangle Consortium of Reproductive Biology, Research Triangle, NC

Evans-Hoeker, E., Lessey, BA; Differential Expression of Zinc Finger Proteins 36 (ZFP36s) Family and Leukemia Inhibitory Factor (LIF) in Human Endometrial Epithelium and Stroma. American Society for Reproductive Medicine Conference, Boston, MA, 10/16/13

BA Lessey, SL Young, C Tayade, JY Yoo, J Jeong, AT Fazleabas; Inflammatory and Angiogenic Reponses are Altered in Decidualized Endometrial Stroma from Women with Endometriosis, American Society for Reproductive Medicine Conference, Boston, MA, 10/14/13

15

TB Mesen, BA Lessey, GO Canny, L Yuan, AT Fazleabas, SL Young; Marked Stimulation of the Lipoxin A4 Synthesis Pathway During Endometrial Stromal Decidualization in Women With and Without Endometriosis Suggest a Role in Early Pregnancy, American Society for Reproductive Medicine Conference, Boston, MA, 10/16/13

D.A. Forstein, H. McGrath, L. Street, P.B. Miller, C.E. Likes, BA Lessey; Luteal phase support in explained and unexplained recurrent pregnancy loss – American Society for Reproductive Medicine 69th Annual Meeting, Boston, MA, October 12 – 17, 2013

Xilong Li, Rainer B Lanz, JaeWood Jeong, Steven L Young, BA Lessey, Wilder A Palomino, Sophia Tsai, Francesco J DeMayo; COUP-TFII regulates human endometrial stroma genes involved in inflammation – American Society for Reproductive Medicine 69th Annual Meeting, Boston, MA, October 12 – 17, 2013

SJ Oh, JH Shin, TH Kim, HS Lee, JY Yoo, RR Broaddus, MM Taketo, JP Lydon, RE Leach, BA Lessey, AT Fazleabas, JM Lim, JW Jeong; Beta-catenin Activation Contributes to Pathogenesis of Adenomyosis Through Epitherial-Mesenchymal Transition – Society for the Study of Reproduction 46th Annual Meeting, Montreal, Canada, July 22-26, 2013

MK Adur, AG Braundmeier-Fleming, SL Young, BA Lessey, RA Nowak; Alteration in Endometrial Expression of T Cells Indicates a Pro- Inflammatory Milieu in the Eutopic Endometrium of Women with Endometriosis-Related Infertility - Society for the Study of Reproduction 46th Annual Meeting, Montreal, Canada, July 22-26, 2013

Niraj Joshi, Ren-Wei Sui, Plavita Sharma, Samantha Bond, BA Lessey, Asgi Fazleabas; Increased Expression of microRNA-29c (miR- 29c) May Contribute to Endometriosis Induced Progesterone Reisistance in Baboon Eutopic Endometrium (EUE) – Society for the Study of Reproduction 46th Annual Meeting, Montreal, Canada, July 22-26, 2013

Daniel D Carson, Neeraja Dharmaraj, Patricia J Chapela, Micaela Morgado, Shannon M Hawkins, BA Lessey, Steven L Young; A Comparative Study of the Transmembrae Mucins, MUC1, MUC4 and MUC16 in Endometria of Normal Women and Women with Endometriosis – Society for the Study of Reproduction 46th Annual Meeting, Montreal, Canada, July 22-26, 2013

M Morgado, N Dharmaraj, P Chapela, SM Hawkins, BA Lessey, SL Young, DD Carson; MUC1, MUC4 and MUC16 Expression in Endometria of Normal Women and Women with Endometriosis – Texas Forum for Reproductive Sciences, Houston, TX, April, 2013

E Evans-Hoeker, L Yuan, BA Lessey, SL Young; B Cell Lymphoma Protein 6 (BCL-6), Suppressor of Cytokine Signaling 2 (SOCS2) and their Potential Role in Endometriosis – 60th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL, March 19-23, 2013

DC Sridharan, DD Taylor, BA Lessey, C Gercel-Taylor; Characterization of Ovarian Antibody Reactivity with Cellular and Exosomal Antigens in Patients with Endometriosis – 60th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL, March 19-23, 2013

BA Lessey, JY Yoo, JW Jeong, S Gill, L Yuan, SL Young, AT Fazleabas; Suppressor of Cytokine Signaling (SOCS) Expression in Normal and Abnormal Endometrium – 60th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL, March 19-23, 2013

TB Mesen, BA Lessey, GO Canny, L Yuan, DD Taylor, SL Young; Lipoxin A4 (LXA4) Synthesis Pathway is Cycle Regulated in Human Endometrium and Dysregulated in Women with Endometriosis – 60th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL, March 19-23, 2013

BA Lessey, M Nagarkatti, J Zhou, SL Young, MK Adur, RA Nowak; Peripheral and Local Cytokines including IL-8, IL-9 and IL-17 are Elevated in Endometriosis: An In Vivo and In Vitro Analysis Before and After Surgery Suggests a Mechanism for Endometrial Dysfunction – ASRM 68th Annual Meeting, San Diego, CA, October 20-24, 2012

BA Lessey, KJ Holoch, J Franasiak, L Yuan, MA Fritz, SL Young; Prospective assessment of mid-secretory endometrial LIF and β3 integrin expression as a predictor of pregnancy outcome and endometriosis in unexplained infertility – 28th Annual Meeting of ESHRE, Istanbul, Turkey, July 1-4, 2012

N Joshi, R Su, BA Lessey, A Fazleabas; Decreased Expression of miR-451 Alters YWHAZ (14.3.3ζ) in the Eutopic (EUE) and Ectopic Endometrium (EcE) in a Baboon Model of Endometriosis – 59th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA, March 21-24, 2012

16 A Fazleabas, N Joshi, M Gadisetti, J Chen, S Ho, BA Lessey; Epigenetic Modifications in the Eutopic Endometrium (EUE) of Women with Endometriosis and Infertility – 59th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA, March 21-24, 2012

JF Franasiak, BA Lessey, L Yuan, MA Fritz, SL Young; Endometrial CXCL13 Expression is Cycle Related and Aberrant in Endometriosis – 59th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA, March 21-24, 2012

J Franasiak, BA Lessey, L Yuan, K Holoch, MA Fritz, SL Young; Endometrial LIF Expression Correlates with β3 Integrin Expression in Endometriosis – Triangle Consortium for Reproductive Biology, Chapel Hill, NC, March 3, 2012

L Street, K Holoch, L Nelson, K Amalfitano, A Graham, D Forstein, HL Higdon, III, BA Lessey; Luteal Phase hCG Improves Pregnancy Outcomes but not Pregnancy Rates in Unexplained Recurrent Pregnancy Loss – Society of Maternal Fetal Medicine, Dallas, TX, February 9, 2012

KJ Holoch, A Moorhead, PB Miller, HL Higdon, III, CE Likes, III, BA Lessey; Endometriosis in Women with Polycystic Ovary Syndrome (PCOS) and its Role in Poor Reproductive Outcomes - ASRM, Orlando, FL, October 15-19, 2011

BG Patel, G Bushnell, HL Higdon, III, PB Miller, DA Forstein, BA Lessey; Letrozole Use in Frozen Embryo Transfer (FET) Cycles: Clinical Pregnancy Outcomes in Patients with and without Endometriosis - ASRM, Orlando, FL, October 15-19, 2011

M Adur, A Braundmeier-Fleming, A Fazleabas, B Lessey, R Nowak; Involvement of T-Regulatory Cells and Basigin in the Endometrial Inflammatory Pathway in Endometriosis Related Infertility in Humans, October 2011

B Lessey, G Bushnell, S Miller, T Price; Focal Peritoneal Dysfunction and Endometriosis: A New Theory for Pelvic Pain – WCE 2011, Montpellier, France, September 4-7, 2011

B Lessey, S Young, J Jeong, F De Mayo, N Joshi, A Fazleabas; Resistance to Progesterone Occurs Naturally in the Endometrial Zona Basalis, but Pathologically in Endometriosis: A Molecular Study Involving Coup-TFII and FKBP52 – WCE 2011, Montpellier, France, September 4-7, 2011 B Lessey, G Bushnell, S Miller, T Price; Intraoperative Methylene Blue Dye Staining Detects Peritoneal Defects Associated with Endometriosis and Pelvic Pain – ESHRE, Stockholm, Sweden, July 3-6, 2011 A Germeyer, L Nelson, A Graham, J Jauckus, T Strowitzki, B Lessey; Endometrial Alpha v Beta 3 Integrin Profile Reflects Endometrial Receptivity Defects in Women with Unexplained Recurrent Spontaneous Abortions – ESHRE, Stockholm, Sweden, July 3-6, 2011 S Young, B Lessey, U Balthazar, R Zaino, J Jin, J Sherwin, M Fritz; Defining the Relationship between Progesterone Dose, Endometrial Histology and Gene Expression Using an In Vivo Luteal Phase Defect Model – 58th Annual Meeting of the Society for Gynecologic Investigation, Miami Beach, FL, March 16-19, 2011 N Joshi, Y Afshar, S Young, B Lessey, A Fazleabas; The Expression of the Immunophilin FK506 Binding Protein52 (FKBP52) and the Integrin αvβ3 Is Positively Correlated with Pregnancy in Women with Unexplained Infertility and Endometriosis – 58th Annual Meeting of the Society for Gynecologic Investigation, Miami Beach, FL, March 16-19, 2011 B Lessey, D Forstein, P Miller, M Egbuniwe, R Dodds; Laparoscopic Surgery Improves Outcome and Diagnostic Accuracy in Unexplained Infertility – ASRM, Denver, CO, October 23-27, 2010 E McAdory, D Forstein, H Higdon, III, P Miller, B Lessey, W Boone; Effects of Depot Leuprolide Acetate on Oocyte Harvest in Patients with Endometriosis – ASRM, Denver, CO, October 23-27, 2010 S Young, U Balthazar, J Sherwin, R Zaino, B Lessey, M Fritz; Progesterone Concentration Requirements for Normal Mid-Secretory Endometrial Structure and Function – ASRM, Denver, CO, October 23-27, 2010

W Palomino, S Young, D Barros, P Kohen, L Devoto, B Lessey, The αvβ3 Integrin Associates with Complement Regulatory Protein Decay Accelerating Factor (DAF/CD55) and Osteopontin (OPN) in Endometrial Cells During the Window of Implantation – ASRM, Denver, CO, October 23-27, 2010 C Korch, M Spillman, A Bradford, B Jacobsen, T Jackson, S Murphy, B Helfrich, B Lessey; The Women´s Cancer Cell Genotype Atlas (Wccga): Dna Authentication Of Endometrial Cancer, Ovarian Cancer, And Breast Cancer Cell Lines - 13th Biennial Meeting of the International Gynecological Cancer Society (IGCS) Prague, October 23-26, 2010 EP Guedes Neto, GS Moraes, RA Cristovam, HE Corleta, BA Lessey, RF Savaris; Prospective, Randomized Double Blind Comparison between Raloxifene and Clomiphene Citrate for Ovulation Induction in Polycystic Ovary Syndrome – ESHRE, Rome, Italy, June 27-30, 2010

17 SC Amaya, C Jacobson, A Houwing, BA Lessey: Dietary Impact on Endometriosis: A Closer Look at the Active Ingredients of Red Wine and Soy – 5/2-6/09 American College of Obstetricians and Gynecologists Chicago, Il. Donald F. Richardson Award lecture. Lewis, TF, Lessey, BA; Methylene Blue as an Aid for Diagnosing Endometriosis at Laparoscopy: A Case Report – AAGL 3rd International Congress on Minimally Invasive Gynecology-AGES XIX Annual Scientific Meeting, Brisbane, Australia, May 21-23, 2009 Wise JD, Jacobsen C, Houwing A, Fru KN, Buzzell D, Young SL, Lessey BA, Hestermann EV: Aryl Hydrocarbon Receptor Activity is Associated with Endometriosis and Progesterone Insensitivity 03/09 SGI, Glasgow, Scotland Reproductive Sciences 2009;16: 283A. Lessey BA, Hays S, Young SL, Jeong JW, DeMayo FJ, Palomino WA. Progesterone Signaling in Full Thickness Human Endometrium Throughout the Cycle. SGI, 03/09 Glasgow, Scotland. Reproductive Sciences 2009;16 (3 Suppl): 368A Plante BJ, Yuan L, Yang X, Lessey BA, Froung SL. Human Endometrial GPER Signaling and Protein Expression Suggest Physiological Function. 03/21 SGI, Glasgow, Scotland. Reproductive Sciences 2009;16 (3 Suppl):374A Lessey BA, Young SL, Larson SF, DeMayo FJ, Jeong J, Savaris RF, Giudice LC: Characterization of Mig-6 Expression in Normal and PCOS Endometrium Suggests a Mechanism for Endometrial Hyperplasia and Cancer”, 3/26-29/08 SGI Annual Meeting, San Diego, CA Reproductive Sciences 2008; 15: 3A-57A Lessey BA, Parnell BA, Forstein DA, Miller PB, Higdon III HL, Boone WR: Integrin Testing to improve Success Rates in IVF: A Role for GnRHa and Letrozole as Treatment Options for Women with Implantation Failure – 11/08-12/2008 American Society for Reproductive Medicine, San Francisco, CA Piante BJ, Yuan L, Lessey BA, Fritz MA, Young SL: In Vivo and In Vitro Evidence for ER Regulation of G Protein-Coupled Estrogen Receptor (GPER) Expression in normal women and those with Endometriosis – 11/08-12/2008 American Society for Reproductive Medicine, San Francisco, CA Burney RO, Hamilton AE, Bo KC, Nezhat CR, Lessey BA, LC Guiudice: Microrna Expression Profiling of Eutopic Endometrium from Women with Versus Without Moderate-Severe Endometriosis – 11/08-12/08 American Society for Reproductive Medicine, San Francisco, CA Fassbender A, D’Hooge T, Mihalyi A, Kyama CM, Simsa P, Lessey BA, Leuven L, Belguim: The Relationship between C3A-DES-ARG and Endometriosis – 11/08-12/2008 American Society for Reproductive Medicine, San Francisco, CA Amaya SC, Houwing A, Jacobson C, Lessey BA: Dietary Impact on Endometriosis: A Closer Look at the Active Ingredients of Red Wine and Soy - 10/3-4/2008, Carolina Women’s Health, Columbia, SC Nelson LE, Forstein DA, Higdon HL, Lessey BA: Treatment of Unexplained Recurrent Pregnancy Loss with HCG Support - 10/3-4/2008, Carolina Women’s Health, Columbia, SC Savaris R, Groll JM, Young SL, Jeong JW, DeMayo FJ, Giudice LC, Lessey, BA “Insulin and Progesterone Resistance in PCOS Endometrium: a Microarray Analysis in Clomiphene Citrate-treated and Artificial Menstrual Cycles” 10/3-4/2008, Carolina Women’s Health, Columbia, SC Holoch K, Forstein DA, Miller PB, Higdon HL, Lessey BA: Endometriosts in Women with Polycystic Ovary Syndrome (POCS) 10/08, Carolina Women’s Health, Columbia, SC Lessey BA, Holoch K, Forstein DA, Miller PB, Higdon III HL: Endometriosis in Women with Polycystic Ovary Syndrome (PCOS) 11/086th Annual Meeting of the Androgen Excess and PCOS Society, San Francisco, CA Amaya S, Lessey BA, Jacobsen C, Houwing A, Dietary Impact on Endometrosis: A Closer Look at the Active Ingredients of Red Wine and Soy. ACOG District IV, 2008, 7/23/08. Savaris, R, Groll JM, Young SL, Jeong JW, DeMayo FJ, Giudic, LC, Lessey BA “Insulin and Progesterone Resistance in PCOS Endometrium: a Microarray Analysis in Clomiphene Citrate-treated and Artificial Menstrual Cycles” ESHRE 24th Annual Meeting 2008 Barcelona, Spain. O-003 Plante BJ, Yuan L, Lessey BA: Regulation and Signaling of the Membrane Estrogen Receptor, GPR30 in Human Endometrial Cells (Reproductive Sciences 55th Annual Meeting, March 26-29, 2008, San Diego, CA, Volume 15 #2.) Young SL, Usadi R, Lessey BA, Groll J, Fritz M: Low Luteal Progesterone Levels Do Not Alter Midsecretory Endometrial Gene Expression or Histology, (Reproductive Sciences 55th Annual Meeting, March 26-29, 2008, San Diego, CA, Vol. 15 #2) Palomino WA, Likes CE, Mo B, Forstein DA, Miller P., Lessey BA, Progesterone Resistance in Endometriosos: Examiniation of L- Selectin Ligand in Eutopic and Ectopic Endometrium Using In Vivo and In Vitro Models. 63RD Annual Mtg American Society for Reproductive Medicine, Washington, DC. 10/07. Fertility and Sterility, Vol. 88, Sup. 1, September 2007.

18 Burney RO, Talbi S, Hamilton AE, Chi Vo K, Nygaard M, Nezhat CN, Lessey BA, Giudice LC. Molecular Profiling of the Endometrium Reveals Progesterone Resistance in Endometriosis. 53rd Annual Meeting of the SGI, Reno, NV, 3/14/07. Supplement to Reproductive Sciences, Formerly Journal of the Society for the Gynecologic Investigation, Vol. 14, Number 1 01/07. Young SL, Scotchie JG, Palomino, WA, Lessey BA, Expression, Regulation, and Possible function of the Alternative Estrogen Receptor, GPR30, in Human Endometrial Cells. 53rd Annual Meeting of the SGI, Reno, NV, 3/14/07. Supplement to Reproductive Sciences, Formerly Journal of the Society for Gynecologic Investigation, Vol. 14, Number 1 (Supplement) January 2007. Lessey BA, Palomino WA, Hucks MA, Mo B, Miller PB, Forstein DA, Univ. Medical Group, Greenville, SC. Measurement of Activated Complement Subunit C3: A Prospective controlled Evaluation of a New Test for Infertility and Implantation Failure. Fertility and Sterility Sept. 2006, Vol. 86, Sup. 2, P470. Collins NH, Lessey EC, Fowler L, Palomino WA, Houwing AM, Lessey BA, Univ. Medical Group, Greenville, SC: Univ. of North Carolina, Chapel Hill, NC, Herbal Therapy For Endometriosis: Prunella Vulgaris (Self Heal) Reduces the Size and Number Endometriotic Xenografts in Immunodeficient RAG-2/GAMMA (C) Knockout Mice. 62nd Annual Mtg of the American Society for Reproductive Medicine, New Orleans, LA, 10/06. Fertility and Sterility Sept. 2006, Vol. 86, Sup. 2, P-374. Talbi S, Hamilton AE, Nezhat C, Lessey BA, Guidice LC, Gene Expression Profiling of Eutopic Endometrium From Women With Severe Endometriosis. 53rd Annual Meeting of the SGI, Reno, NV, 3/14/07. Fertility and Sterility Sept. 2006, Vol. 86, Sup. 2, P-369. MacLaughlan SD, Mo B, Palomino A, Lessey BA CYR61 Expression in Normal and Abnormal Endometrium: A Marker of Estrogenic Activity ACOG, Annual meeting, Washington, DC, 5/06. Donald F. Richardson Award lecture. Organ EL, Yearman GR, Osteen KG, Lessey BA, McGuinness DH Serum diagnosis of endometriosis using autoantibodies against Thomsen-Friedenreich antigen bearing proteins. IX World Congress on Endometriosis, Maastricht, Netherlands, 2005. E.J Obstet Gynecol 123: S61, 135. Igarashi TI, Bruner-Tran KB, Yearman GY, Eisenburg EE, Edwards DE, Lessey BA, Liang SL, Ayabe TA, Tsutsumi OT, Taketani YTl, Osteen KO Decreased expression of progesterone receptor B isoform in the endometrium from patients with endometriosis. IX World Congress on Endometriosis, Maastricht, Netherlands, 2005. E.J Obstet Gynecol 123: S4, O1.5. MacLaughlan SD, Mo B, Palomino A, Lessey BA CYR61 Expression in Normal and Abnormal Endometrium: A Marker of Estrogenic Activity ACOG, District IV Annual meeting, Cabos, San Lucas, 10/05. Merritt WM, Mo ., Lessey EC, Hansen M, Lessey BA. Dectection and characterization of isolated androgen receptor expression in the human endometrial cell line, HEC1-B. ACOG Annual Mtg; Prize Paper for Junior Fellows, San Francisco, CA 5/2005 Merritt WM, Mo B, Lessey EC, Hansen M, Lessey BA. Dectection and characterization of isolated androgen receptor expression in the human endometrial cell line, HEC1-B. Am. College OBGYN, District IV, Savannah, GA, 2004 Lessey EC, Mo B, Yu X and Lessey BA. The Chinese Herb, Prunella Vulgaris, Exhibits Anti-estrogenic Activity and Inhibits Proliferation of the Endometrial Cancer Cell Line, ECC-1. Soc. Gynecol. Invest. Annual Mtg, March, 2004, Los Angeles, CA. Mo B, Hansen MA, Lessey BA Regulation of Steroid Receptor Isoforms in a Well-Differentiated Endometrial Cancer Line, ECC-1. SSR 37th Annual Meeting, Vancouver, British Columbia, Canada, August 2004 Abstract: LES-1078-173742. Lininger RA, Ding X., Livasy CA, Sciarrotta J, Perou CM, Lessey BA. Differential expression of cytokeratins 13 and 18 in Type 1 versus Type 2 endometrial carcinomas using tissue microarrays. United States and Canada Academy of Pathology Annual Meeting. Washington, D.C. March 22-28, 2003. Abst. 122, pg 82. Zaino R, Novotney D, Ireland K, Meyer W, Fritz MA, Lessey BA, Murray, M. Dating the endometrial biopsy: A re-evaluation. United States and Canada Academy of Pathology Annual Meeting. Washington, D.C. March 22-28, 2003. Pg. 36. Kao LC, Tulac S, Imani B, Yang JP, Lessey BA, L.C. Giudice Expression Profile Comparisons in Eutopic Endometrium between women with and without Endometriosis. VIIIth World Congress on Endometriosis, San Diego, CA, 2/2002 (Prize poster). Groll JA, Brown AL, Apparao KBC, Gregory CW, Wilson EM, Lessey BA Overexpression of P160 steroid receptor coactivators (SRCs) in endometrial cancer. Fertility and Sterility - September 2003 Vol. 80, Issue (Supplement 3), Page 4) Usadi RS, Lessey BA, Kowalik, AI, Meyer WR, Fritz MA The effects of low luteal phase progesterone concentrations on the histologic and functional characteristics of the endometrium. J. Soc. Gynecol. Invest. (Supp). 10:386A. Abst. #888. Tulac S, Nayak N, Lessey B, Giudice L.C. Identification and characterization of a canonical Wnt signaling pathway in normal human endometrium. J. Soc. Gynecol. Invest. (Supp). 10:185A. Abst. #286.

19 Groll, J.A., Marshall, J.C., Evans, W.S., Giudice, L.C., Lessey, BA Endometrial gene profiling in women with polycystic ovarian syndrome compared to normal women. J. Soc. Gynecol. Invest. (Supp). 10:178A. Abst. #266. Young SL, Lessey BA, Lyddon TD and Misfeldt ML. Toll-like receptor expression in human endometrium. J Soc Gynecol Invest (Supp) 2002; 9:74A-Abst. 27. Vendrov AE, Apparao KBC, Lininger RA, Young SL and Lessey BA. Human endometrial adenocarcinoma cell lines, ECC-1 and Ishikawa, exhibit a luminal vs. glandular phenotype, respectively. J Soc Gynecol Invest (Supp) 2002; 9:326a-abst. 805. Lessey BA, Gregory CW, Wilson EM, Apparao KBC, Lininger RA, Kowalik A, Meyer WR and Fritz MA. Steroid receptor coactivator (p160) expression throughout the menstrual cycle in normal and abnormal endometrium. J Soc Gynecol Invest (Supp) 2002; 9:263-abst 609. Lessey BA, Apparao KBC, Young SL, Lininger RA, Usadi RS, Groll J and Fritz MA. Endometrial estrogen receptor- increased in women with defects in uterine receptivity: A unifying concept for implantation failure? J Soc Gynecol Invest (Supp) 2002; 9:493-Abst. 496. Usadi R, Bagnal R, Murray MJ, Meyer WR, Fritz MA, Lessey BA Distribution of Pinopods in the Secretory Phase: A Prospective, Randomized Assessment in Healthy, Fertile Women. O-102, S39. ASRM Annual Meeting, Orlando, FL 10/2001. Lessey BA, Appa Rao KBC, Chambers AF, Usadi R, Madden V, Bagnell R. Osteopontin normally localized to the apical surface of receptive endoemtrium, is lacking in women with endometriosis and aberrant avß3 integrin expression. O-160, S60, ASRM Annual Meeting, Orlando, FL 10/2001. Kao,LC, Yang J, Lessey BA, Giudice LC. Discovery of candidate genes for human uterine receptivity by GeneChip® Microarray Expression Profiling. O-159, S59. ASRM Annual Meeting, Orlando, FL 10/2001. Gargiulo AR, Wang ZC, Lessey BA, Xiao L, Politch J, Hill J. 2001 Differential expression of integrin genes in septal and parietal endometrium of women with recurrent pregnancy loss. ASRM Annual Meeting, Orlando, O-155, S58. FL 10/2001. Kao LC, Yang J, Lessey BA, Giudice LC. 2001 Gene expression profiles in human endometrium during the implantation window from subjects with endometriosis, using GENECHIP® microarray technology. Endocrine Society Annual Mtg, Denver, CO. Williams CD, Lessey BA, Meyer WR, Kowalik AI, Usadi RS, Fritz MA. 2001 Influence of Age On Histologic And Functional Characteristics Of Endometrial Response To Programmed Sequential Hormonal Replacement With Estradiol (E2) And Progesterone (P). SGI Annual Meeting, Toronto poster presentation. Appa Rao KBC, Chambers AF, Lessey BA. 2001 Progesterone receptor isoform-B modulates the expression of osteopontin in human endometrial epithelium during the window of implantation. SGI Annual Meeting, Toronto, oral presentation. Appa Rao KBC, Lovely L, Gui Yaoting, Lessey BA. Overexpression of endometrial androgen receptors in women with polycystic ovarian syndrome: An underlying cause for poor reproductive function? SSR, Madison, WI 7/00, #512 poster presentation. Sharpe-Timms KL, Cox KE, Bidisha R, Lessey BA, Localization of matrix metalloproteinase (MMP) enzymes, MMP-2 and MMP-3, to luminal endometrial epithelia by interaction with avß3 and V5 integrins during the window of implantation. SSR, Madison, WI 7/00, #447 slide presentation. Murray M, Lessey BA, Soy phytoestrogens decrease the estrogenic activity of estradiol in an in vitro bioassay using a human endometrial cell line. Pacific Coast Reproductive Society, 4/00, oral presentation. Yuan L, Bray PF, Lessey BA. Endometrial 3 integrin subunit gene expression is mediated by SP1. Annual SGI Meeting, Chicago, 3/00, #23. Young SL, Lessey BA, Murray MJ, Nagamani M, Nowicki B. Regulation and function of human endometrial decay accelerating factor (DAF). SGI Annual Meeting, Chicago 3/00, #47. Williams CD, Boggess JF, LaMarque LR, Meyer WR, Murray MJ, Lessey BA. Dynamic expression of endometrial telomerase in the luteal phase. SGI Annual Meeting, Chicago 3/00 #628. Appa Rao KBC, Illera MJ, Truong PR, Zhang J, Lessey BA. Expression and distribution of osteopontin and its integrin receptor, avß3 in the rabbit endometrium during the peri-implantation period. SGI Annual Meeting, 3/00 Chicago #50. Allaire AD, D’Andrea N, McMahon MJ, Lessey BA. Cervical stromal apoptosis during labor. Annual SGI Meeting, 3/00 Chicago #300. Boggess JF, Lamarque LR, Morrissey TP, Roayaei JA, Lessey BA, Telomerase expression in exfoliated cervical cells correlates with known cervical cancer risk factors. Society of Gynecologic Oncologists 200 Annual Meeting, San Diego, CA, 2/00, poster presentation.

20 Vaidya EL, Lessey BA, Illera MJ, Gui YT. Endometriosis and endometrial receptivity in a rabbit model. UNC Student Research Day 1/00. Yuan L, Bray PF, Lessey BA. Human 3 integrin gene expression is mediated by SP1. Triangle Consortium for Reproductive Biology, NCSU, 1/00 #55. Appa Rao KBC, Lovely L, Gui YT, Lessey BA. Over expression of endometrial androgen receptors in women with polycystic ovarian syndrome: an underlying cause of poor reproductive function? Triangle Consortium for Reproductive Biology, NCSU, 1/00 #28. Klinman HJ, Van Deerlin PG, Lessey BA, Feinberg RF. ß3 integrin and MAG mucin in luteal phase glandular endometrium: a comparative marker study. ASRM, Toronto, Canada. 9/99, oral presentation. McAdams D, Truong P, Lovely L, Lessey BA. Randomized prospective comparison of hCG versus progesterone to prevent apoptosis in late luteal phase endometrium. 46th Annual Meeting of the Society of Gynecologic Investigation. 3/99, poster presentation. Illera M, Gui Y, Mohammand A, Lessey BA. Perturbation of Implantation Rate by Neutralization of the avß3 Vitronectin Receptor in Rabbits. 46th Annual SGI Meeting. 3/99. Lessey BA, Gui Y, Yuan L, Zhang J. Comparison of Endometrial avß3 Integrin Expression with Other Markers of Uterine Receptivity, LIF and HOXA-10. 46th Annual SGI Meeting. 3/99. Gui Y, Yuan L, Zhang J, Lessey BA. HOXA-10 is Regulated in the Endometrium During the Menstrual Cycle in Women. 46th Annual SGI Meeting. 3/99. Gui Y, Yuan L, Zhang J, Mulholland J, Lessey BA. Is Heparin-binding EGF a Stromal Factor that Regulates Uterine Receptivity? 46th Annual SGI Meeting. 3/99. Tabibzadeh S, Shea W, Lessey BA, Satyaswaroop PG. Aberrant expression of ebaf in endometria of patients with infertility. IFFS/ASRM. 3/98. Abstract#P/874 Saraf M, Ferrer K, Lessey BA, Fazleabas AT. Regulation of Cyclins E and D1 and the P21 WAF1/CIP1 Inhibitor in the Human Uterus During the Menstrual Cycle and Early Pregnancy. IFFS/ASRM. 3/98. Abstract #0/181. Gui Y, Murray MJ, Truong PR, Edgell CJ, Lessey BA. EA hy926 cells are an excellent model to study the role of integrins and growth factors in angiogenesis. IFFS/ASRM. 3/98. Abstract #P/516. Tabidzadeh S, Lessey BA, Satyaswaroop PG. Aberrant expression of TGF-ß4 in infertile endometria. IFFS/ARSM. 3/98. Abstract #P/874. Lessey BA, Implantation and cell adhesion molecules. Journal of Reproductive Immunology. 8/97. Abstract #5/1. Lessey BA, Young SL, Guarino dA, Yuan L. Critical events in the establishment of uterine receptivity may depend on the down- regulation of the endometrial progesterone receptor. Triangle Consortium for Reproduction Biology. 1/25/97. Abstract #30. Wolf LJ, Novotny DB, Lessey BA and Fritz MA. Effect of Experimental Variations on Endometrial Thickness on Histologic Maturation and Epithelial Integrin Expression in Implantation Phase Endometrium in Normal Women. 1997 Society for Gynecologic Investigation. Abstract number 431. Lovely, LP, Odom, LD, Fritz, MA, Meyer, WR, Harris, JE, Lessey, BA. Correlation of v3, Serum Progesterone and Endometrial Thickness with Histologic Dating: Implications for Identification of Uterine Receptivity Defects. Society for Gynecologic Investigation. 1997. Abstract number 384. Arnold, JT, Lessey, BA, Kaufman, DG. Effect of Extracellular Matrix on Endometrial Stromal Cell Regulation of Epithelial Cell Functioning. American Association for Cancer Research. 1997. Abstract number 1725. Boggess, J, Watson, J, Lessey, BA, VanLe, L, Fowler, WC, Haskill, S. Inverse Relationship Between Alpha-2 Integrin Expression and Tumorigenicity: Immortilization of Human Granulosa Cells and Comparison with Normal and Tumorigenic Cells. American Association of Cancer Research. 1997. Abstract number 13371. Rodriguez, GC, Walmer, D, Lessey, BA, Cline, M, Krigman, H, Hughes, CL. The Effect of Contraceptive Progestins on the Ovarian Epithelium: Cancer Prevention Through Apoptosis. Society for Gynecological Investigation. 1997. Abstract number 4. Boggess J, Gould N, Lessey BA, Van Le L. Integrin Expression Analysis Suggests that Granulosa Cell Tumors are Epithelial Neoplasms. Society for Gynecological Investigation. 1997. Abstract number 578. Illera, MJ, Das, SK, Dey, SK, Yuan L, Stewart C, Cullinan E, Lessey BA. The avß3 Vitronectin Receptor in the Mouse Uterus: A Potential Role During Implantation. Society for Gynecological Investigation. 1996. Abstract number 216.

21 Lessey BA, Castelbaum AJ, Somkuti SG, Harris J, Sun J, Young SL. Differences in Treatment Outcome in a Subset of Women with Infertility and Minimal or Mild Endometriosis and Abberrant avß3 Expression. Society for Gynecologic Investigation. 1996. Wolf, LJ, Novotny DB, Lessey BA, Fritz MA. Influence of Variations in Endometrial Thickness on Subsequent Secretory Development and Epithelial Integrin Expression in the Implantation Phase Endometrium. Society for Gynecologic Investigation, Boston, 1996. Lessey BA, Castelbaum AJ, Somkuti SG, Harris J, Sun SL, Young, SL, Wolf L. Improvement in Pregnancy Rates with GnRH Agonist in Women with Infertility, Minimal or Mild Endometriosis and Aberrant avß3 Expression . American Society for Reproductive Medicine, 52nd Annual Meeting, Nov. 2-7, 1996, Boston. Abstract 0-165, pg S82. Meyer, WR, Novotny, DB, Wolf, LJ, Somkuti, SG, Lessey, BA, Fritz, MA. Effects of Controlled Overian Hyperstimulation on Endometrial Maturation in Oocyte Donors. SGI, Philadelphia, Pennsylvania, 3/96, Abstract number 183. Yuan L, Bray PF, Young SL, Lessey BA. Estrogen, Progesterone and EGF action on the human 3 integrin promoter: implications for the establishment of endometrial receptivity. SGI, Philadelphia, Pennsylvania, 3/96, Plenary Slide Session, Abstract # 0-4 (presentation). Wolf LJ, Novontny DB, Meyer WR, Lessey BA, Fritz MA. Dyssynchronous Glandular/Stromal Endometrial Maturation: Prevalence in Normally Cycling Proven or Presumed Fertile Women. SGI, Philadelphia, Pennsylvania, 3/96, Abstract number 269. Ruman J and Lessey BA. Integrins as markers of uterine receptivity in a mouse model. Fax. UNC Student Medical Journal 10:76, 1995. Lessey BA, Castelbaum AJ, Bellardo L, Shell K, Sun JH, Somkuti SO. Defective Endometrial Receptivity: An Under-Appreciated Cause of Idiopathic Recurrent Pregnancy Loss. ASRM, Seattle, Washington, 10/95, Abstract #595 (presentation). Illera MJ, Rumen J, Yuan LW, Lessey BA. Peritoneal Fluid from Infertile Women with Endometriosis and Aberrant Endometrial Integrin Expression Blocks Embryo Implantation in a Mouse Model. Endocrine Society, Washington, DC, 6/95. Abstract #P2-98 (poster). Krasnow JS, Guzick DS, Fraus G, Lessey BA, Berga St. Comparison of Transdermal vs Oral Estradiol Therapy on Endometrial Receptivity. SGI, Chicago, IL, 3/95. Abstract #P294, p. 363. Somkuti SO, Yowell CW, Lessey BA. Epidermal Growth Factor and Human Uterine Receptivity: Regulation of the avß3 Integrin Vitronectin Receptor. SGI, Chicago, IL: 3/95. Abstract #0120, p. 196. Grosskinsky CM, Yowell CW, Sun J, Parise LV, Lessey BA. Modulation of Integrin Expression in Endometrial Stromal Cells In Vitro. SGI, Chicago, IL, 3/95. Abstract #0123, p. 198. Castelbaum AJ, Sun J, Shell K, Fritz M, Freedman MF, Lessey BA. Decreased avß3 Integrin Expression Identifies Abnormal Endometrial Phenotype in Luteal Phase Deficiency (LPD). SGI, Chicago, IL, 3/95. Abstract #P285, p. 359 Sayegh R, Awwad J, Maxwell C, Isaacson K, Lessey BA, Schiff I. Alpha 2 Macroglobulin (A2M) Production by Human Endometrium. The American Fertility Society, San Antonio, TX, II/94. Abstract Program #149, p. 573. Castelbaum AJ, Riben M, Howarth J, Tureck R, Lessey BA. Minimal Endometriosis Impairs Endometrial avß3 Integrin Expression and Cycle Fecundity Compared to Tubal Factor Patients in an IVF Program. The American Fertility Society, San Antonio, TX, 1 1/94. Poster Session #007, p. 589. Somkuti SO, Yowell CM, Lessey BA. Effect of Oral Contraceptive Pills on Markers of Uterine Receptivity, The American Fertility Society, San Antonio, TX, l 1/94. Abstract O-139, p. 568. Lessey BA, Castelbaum AJ, Guzick D, Sun J, Fritz M. The use of Integrins as Markers of Uterine Receptivity to Date the Endometrial Biopsy, The American Fertility Society, San Antonio, TX, II/94. Abstract 0-077, p. 538. Lessey BA, Castelbaum AJ, Riben M, Howarth J, Tureck R, Meyer YR. Effect of Hydrosalpinges on Markers of Uterine Receptivity and Success in IVF, The American Fertility Society, San Antonio, TX, Il/94. Abstract 0-091, p. 545. Ying L, Castelbaum Afl, Yowell CW, Somkuti S, Lessey BA. Characterization of integrin subunits in a hormone-responsive endometrial carcinoma cell line. The Endocrine Society 76th Annual Meeting, Anaheim CA, June 15-18, 1994., Abstract #197, p. 250. Castelbaum AJ, Sawin SW, Lessey BA. Endometrial integrin expression of diethylstilbestrol exposed compared to normal women. Society for Gynecologic Investigation, Chicago, March 22-25, 1994. Abstract 017. Page 95. Lessey BA, Ling L, Castelbaum AJ. Endometrial integrins and the window of implantation. Society for Gynecologic Investigation, Chicago, March 22-25, 1994. Abstract 02. Page 87.

22 Castelbaum A, Wheeler J, Mastroianni L, Coutifaris C, Lessey BA. Timing of the endometrial biopsy may affect the incidence of out of phase (OOP) endometrium: Two biopsies in a single menstrual cycle. 49th Annual Meeting of the American Fertility Society, Montreal, October 9-14, 1993, AFS Abstract O-042, p. 520. Olt G, Lessey BA, Hung Y-C. Ovarian cancer cell adhesion proteins and integrins. Connective Tissue Research 28:232, 1993. Lessey BA, Berchuck A, Kohler M, Yeh I-T, Albelda SM, Buck CA. Distribution of integrin adhesion molecules in normal and neoplastic human endometrium. Connective Tissue Research 28:235, 1993. Coutifaris, C. and Lessey, BA. Co-expression of endometrial osteopontin and its receptor, the ( receptivity to embryo implantation. Society for Gynecologic Investigation, Toronto, 4/93. S-135. Page 136. Lessey BA and Castelbaum A. Characterization of the ( patients with unexplained infertility: A prospective controlled study. Society for Gynecologic Investigation, Toronto, 4/93. Abstract #168. Page 152. Coukas G, Lessey BA, Coutifaris C. Human trophoblast implantation: A role for the Bs integrin subunit in trophoblast attachment and migration. 4Sth Annual Meeting of the American Fertility Society, New Orleans, LA. 10/92 Lessey BA. Integrin cell adhesion molecules: Immunohistochemical evaluation of endometrial integrin receptor subunits and extracellular matrix components in endometriosis. 48th Annual Meeting of the American Fertility Society, New Orleans, LA. 10/92. Lessey BA, Coutifaris C, Coukas G, and CA Buck. Uterine receptivity and the ( vitronectin receptor: Is this integrin the embryo attachment receptor in the human endometrium? Endocrinology of Embryo-Endometrial Interactions. Satellite Symposium of the Ninth International Congress of Endocrinology (N.I.C.E. 92), Bordeaux, France. 9/92. Abstract #66. Lessey BA, Ilesanmi AO. Characterization of a functional progesterone receptor in a human endometrial cancer cell line. Society of Gynecologic Invest. San Antonio, TX, March, 1992. Hasty LA, Lessey BA, Pruksanononda K, Lambris J, Lyttle, CR. The hormonal regulation of complement components throughout the menstrual cycle. Society of Gynecologic Invest. San Antonio, TX, March, 1992. Lessey BA, Damjanovich L, Albelda SM, Buck CA, Coutifaris C. Distribution of integrin adhesion molecules in the human uterus throughout the menstrual cycle. Society of Gynecologic Investigation, 1991. San Antonio, TX. Abstract #401. Lessey BA, Castelbaum A, Ilesanmi A, Yeh I. Immunohistochemical diagnosis of luteal phase deficiency: Comparison between Endometrial Progesterone Receptor Distribution and TAG-72. The Endocrine Society, Washington C.C., 1991. Abstract #1670. Lessey BA, Pindzola A. Expression of TAG-72 in normal and ectopic endometrium. American Fertility Society, Washington D.C., ID/90, Abstract #115. Hasty LA, Lessey BA, Lyttle CR. Hormonal regulation of complement C3 production by the human endometrium. First Conference on the Primate Endometrium, Mt. Sinai Hospital, New York, 5/90, Abstract #l. Lessey BA, Coutifaris C, Blasco L, Tureck R, Sondheimer S, Mastroianni L, Jr. Subsequent reproductive performance in women who successfully achieved a pregnancy through in vitro fertilization/embryo transfer. American Fertility Society, 1 l/89, San Francisco. Abstract #P-1 19. Lessey BA, Flowers J, Greene G, Konrath J, Killam A, McCarty KS. Immunohistochemical localization of estrogen and progesterone receptors in the cycling and gravid human uterus. Int Acad Pathology Abstract. Presented at Annual Meeting, Chicago, Il, 1987. Gorell TA, Lessey BA. Progesterone mediated inhibition of nuclear estrogen receptor binding in the beagle uterus. Physiologist 25:216, 1982. Wahawisan R, Lessey BA, Sawyer HR, Gorell TA. Progesterone regulation of canine uterine and oviductal 17ß-hydroxysteroid dehydrogenase. Endocrinology, 1981. Lessey BA, Gorell TA. Progesterone receptors in the uterus and oviduct of the beagle. American Zoologist 19:1979 Lessey BA, Gorell TA. Estrogen receptors in the beagle: In vitro measurement and partial characterization. American Zoologist l 8:1978. Groll JM, Usadi RS, Lessey BA, Lininger R, Young SL, Fritz MA. Endometrial Development and Function in Experimentally Induced Luteal Phase Deficiency. Fertil Steril In Press.

Alternative Media:

2013 Video discussion of methylene blue dye for detection of endometriosis, https://www.youtube.com/watch?v=5EncV3vSiEc

23 2008 Groll JM, Lessey BA: Implantation - The Global Library of Women's Medicine Gynecology and Obstetrics CD-ROM Volume 5 Chapter 47 pp 35 2008 Kelley’s Story – Web-based video presentation on the use of biomarkers of uterine receptivity to help women with recurrent pregnancy loss. 2007 Endometriosis: Video infomercial regarding surgical and medical services at REI in the Greenville Hospital System

Extramural Professional Activities: 2016 Chairman Endometriosis Special Interest Group, ASRM 2016 Abstract Committee Chair, Endometriosis Special Interest Group, ASRM 2016 2015 – present Scientific Advisory Board Abbvie Pharmaceutical Company 2014 – present Scientific Advisory Board Pfizer Pharmaceutical Company 2016 Research Advisory Board Member, Queens University Group for University Research on the Reproductive and Developmental Origins of Health, Disability and Disease 2015 Abstract Moderator, Session: Endometriosis, ASRM 2015, Baltimore, MD 2014 Program Chair, Long-Term Management of Endometriosis, Improved and Individualized Approaches, ASRM 2014, Honolulu, HI 2014 Abstract Committee Vice-Chair, Endometriosis Special Interest Group, ASRM 2014 1997 - 2011 U54 Endometrial Focus Group, as part of the Specialized Cooperative Centers Program in Reproduction and Infertility Research

Publications: Peer Reviewed Journal Articles:

Ahn SH, Khalaj K, Young SL, Lessey BA, Koti M, Tayade C. Immune-inflammation gene signatures in endometriosis patients. Fertil Steril. 2016 Jul 27. pii: S0015-0282(16)61408-5. doi: 10.1016/j.fertnstert.2016.07.005. PMID: 27475412

Fox C, Morin S, Jeong JW, Scott RT Jr, Lessey BA. Local and systemic factors and implantation: what is the evidence? Fertil Steril. 2016 Apr;105(4):873-84. doi: 10.1016/j.fertnstert.2016.02.018. Epub 2016 Mar 3.

Fox C, Fru K, Lessey BA. Yolk Sac Diameter in Multiple Gestations. GHS Proc. May 2016; 1 (1): 47-48.

Strug MR, Su R, Young JE, Dodds WG, Shavell VI, Díaz-Gimeno P, Ruíz-Alonso M, Simón C, Lessey BA, Leach RE, Fazleabas AT. Intrauterine human chorionic gonadotropin infu.sion in oocyte donors promotes endometrial synchrony and induction of early decidual markers for stromal survival: a randomized clinical trial. Hum Reprod. 2016 Apr 26. pii: dew080. PMID: 27122490.

Evans-Hoeker E, Lessey BA, Jeong JW, Savaris RF, Palomino WA, Yuan L, Schammel DP, and Young SL. Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis. Reprod Sci. 2016 May 24. PMID: 27222232.

Yoo JY, Jeong JW, Fazleabas AT, Tayade C, Young SL, Lessey BA. Protein Inhibitor of Activated STAT3 (PIAS3) is Down-Regulated in Eutopic Endometrium of Women with Endometriosis. Biol Reprod. 2016 May 25. pii: biolreprod.115.137158. PMID: 27226311.

Miller PB, Savaris RF, Forstein DA, Likes CE, Nichols C, Cooper LJ, Lessey BA. Laparoscopic surgery improves pregnancy outcomes in women with suspected endometriosis with or without pathological confirmation. Clin Exp Obstet Gynecol. 2016;43(1):31-6. PubMed PMID: 27048014.

Ahn JI, Yoo JY, Kim TH, Kim YI, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Ahn JY, Lim JM, Jeong JW. cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis. Curr Mol Med. 2016;16(3):276-87. PubMed PMID: 26917262.

Monsanto SP, Edwards AK, Zhou J, Nagarkatti P, Nagarkatti M, Young SL, Lessey BA, Tayade C. Surgical removal of endometriotic lesions alters local and systemicproinflammatory cytokines in endometriosis patients. Fertil Steril. 2016 Apr;105(4):968-977.e5. doi: 10.1016/j.fertnstert.2015.11.047. Epub 2015 Dec 14. PubMed PMID: 26698677

24

Kim TH, Yoo JY, Wang Z, Lydon JP, Khatri S, Hawkins SM, Leach RE, Fazleabas AT, Young SL, Lessey BA, Ku BJ, Jeong JW. ARID1A Is Essential for Endometrial Function during Early Pregnancy. PLoS Genet. 2015 Sep 17;11(9):e1005537. doi: 10.1371/ journal.pgen.1005537. eCollection 2015 Sep. PMID: 26378916

Joshi NR, Su RW, Chandramouli GV, Khoo SK, Jeong JW, Young SL, Lessey BA, Fazleabas AT. Altered expression of microRNA-451 in eutopic endometrium of baboons (Papio anubis) with endometriosis. Hum Reprod. 2015 Sep 14. pii: dev229. PMID: 26370665

Hood BL, Liu B, Alkhas A, Shoji Y, Challa R, Wang G, Ferguson S, Oliver J, Mitchell D, Bateman NW, Zahn CM, Hamilton CA, Payson M, Lessey B, Fazleabas AT, Maxwell GL, Conrads TP, Risinger JI. Proteomics of the human endometrial glandular epithelium and stroma from the proliferative and secretory phases of the menstrual cycle. Biol Reprod. 2015 Apr;92(4):106. doi: 10.1095/biolreprod.114.127217. Epub 2015 Feb 18

Kim BG, Yoo JY, Kim TH, Shin JH, Langenheim JF, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Jeong JW. Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis. Hum Reprod. 2015 May;30(5):1069-78. doi: 10.1093/humrep/dev050. Epub 2015 Mar 6. PMID: 25750101

Lessey BA, Young SL. Homeostasis imbalance in the endometrium of women with implantation defects: the role of estrogen and progesterone. Semin Reprod Med. 2014 Sep;32(5):365-75. doi: 10.1055/s-0034-1376355. Epub 2014 Jun 24. PMID: 24959818

Szwarc MM, Kommagani R, Lessey BA, Lydon JP. The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction. Biol Reprod. 2014 Nov;91(5):122. doi: 10.1095/biolreprod.114.125021. PMID: 25297546

Ahn SH, Edwards AK, Singh SS, Young SL, Lessey BA, Tayade C. IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors. J Immunol. 2015 Aug 10. pii: 1501138. PubMed PMID: 26259585.

Chapela PJ, Broaddus R, Hawkins SM, Lessey BA, Carson DD. Cytokine Stimulation of MUC4 Expression in Human Female Reproductive Tissue Carcinoma Cell Lines and Endometrial Cancer. J Cell Biochem. 2015 Apr 29. doi: 10.1002/jcb.25213. PMID:25923310

Hood BL, Liu B, Alkhas A, Shoji Y, Challa R, Wang G, Ferguson S, Oliver J, Mitchell D, Bateman NW, Zahn CM, Hamilton CA, Payson M, Lessey B, Fazleabas AT, Maxwell GL, Conrads TP, Risinger JI. Proteomics of the human endometrial glandular epithelium and stroma from the proliferative and secretory phases of the menstrual cycle. Biol Reprod. 2015 Apr;92(4):106. doi: 10.1095/biolreprod.114.127217. Epub 2015 Feb 18. PubMed

Kim BG, Yoo JY, Kim TH, Shin JH, Langenheim JF, Ferguson Lessey BA, Savaris RF, Ali S, Brophy S, Tomazic-Allen S, Chwalisz K. Diagnostic accuracy of urinary cytokeratin 19 fragment for endometriosis. Reprod Sci. 2015 May;22(5):551-5. doi: 10.1177/1933719114553064. Epub 2014 Oct 8. PubMed PMID: 25296695; PubMed Central PMCID: PMC4519762.

Franasiak JM, Burns KA, Slayden O, Yuan L, Fritz MA, Korach KS, Lessey BA, Young SL. Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and Rhesus macaques with endometriosis. Reprod Sci. 2015 Apr;22(4):442- 51. doi: 10.1177/1933719114542011. Epub 2014 Jul 16. PubMed PMID: 25031316.

Miller PB, Savaris RF, Forstein DA, Likes CE, Nichols C, Cooper LJ, Lessey BA. Laparoscopic surgery improves pregnancy outcomes in women with suspected endometriosis with or without pathological confirmation. Clin. Exp. Obst. & Gyn. ISSN: 0390-6663

Su R, Strug MR, Joshi NR, Jeong J, Miele L, Lessey BA, Young SL, Fazleabas AT. Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization. J Clin Endocrinol Metab. 2014 Dec 29:jc20143720. [Epub ahead of print] PubMed PMID: 25546156.

Savaris RF, Nichols C, Lessey BA. Endometriosis and the enigmatic question of progression. Journal of Endometriosis 2014; 6(3): 121- 126 – published online 9/10/14 11:14:23 AM DOI: 10.5301/je.5000191

Lessey BA, Young SL. Homeostasis imbalance in the endometrium of women with implantation defects: the role of estrogen and progesterone. Semin Reprod Med. 2014 Sep;32(5):365-75. doi: 10.1055/s-0034-1376355. Epub 2014 Jun 24. PubMed PMID: 24959818.

25 Yoo JY, Shin H, Kim TH, Choi WS, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Ha UH, Jeong JW. CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. PloS One, 2014 Jun 23;9(6):e100481. doi: 10.1371/journal.pone.0100481. eCollection 2014. PubMed PMID: 24955763; PubMed Central PMCID: PMC4067330.

Germeyer A, Savaris RF, Jauckus J, Lessey BA. Endometrial beta3 integrin profile reflects endometrial receptivity defects in women with unexplained recurrent pregnancy loss. Reprod Biol Endocrinol. 2014 Jun 20;12(1):53.doi:10.1186/1477-7827-12-53. PubMed PMID: 24950982; PubMed Central PMCID: PMC4074841.

Dharmaraj N, Chapela PJ, Morgado M, Hawkins SM, Lessey BA, Young SL, Carson DD. Expression of the transmembrane mucins MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis. Hum Reprod.2014 Jun 17.pii: deu146. [Epub ahead of print] PubMed PMID: 24939955.

Holoch KJ, Savaris RF, Forstein DA, Miller PB, Higdon HL, Jr., Likes CE, Lessey BA. Co-existence of Polycystic Ovary Syndrome and Endometriosis in Women with Infertility, J Endometriosis 2014; 6(2): 79-83 – published online 5/9/14 10:08:20 AM, DOI: 10.5301/je.5000181

Jason M Franasiak JM, Burns KA, Slayden O, Yuan L-W, Fritz, MA, Korac KS, Lessey BA, Young SL. Endometrial CXCL13 Expression is Cycle Regulated in Humans and Aberrantly Expressed in Humans and Rhesus Macaques with Endometriosis. Reprod Sci, 2014, in press.

Giuliani E, Parkin KL, Lessey BA, Young SL, Fazleabas AT. Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis. Am J Reprod Immunol. 2014 May 8. doi: 10.1111/aji.12259. [Epub ahead of print] PubMed PMID: 24807109.

Franasiak JM, Holoch KJ, Yuan L, Schammel DP, Young SL, Lessey BA. Prospective assessment of mid-secretory endometrial leukemia inhibitor factor expression versus v3 testing in women with unexplained infertility. Fertil Steril. 2014 Mar 29. pii: S0015-0282(14)00180-0. doi: 10.1016/j.fertnstert.2014.02.027. PubMed PMID: 24690239.

Amaya SC, Savaris RF, Filipovic CJ, Wise JD, Hestermann E, Young SL, Lessey BA. Resveratrol and Endometrium: A Closer Look at an Active Ingredient of Red Wine Using In Vivo and In Vitro Models. Reprod Sci. 2014 Mar 6. PubMed PMID: 24604232.

Signe Altmae, Francisco J. Esteban, Anneli Stavreus-Evers, Carlos Simón, Linda Giudice, Bruce A. Lessey, Jose A. Horcajadas, Nick S. Macklon, Thomas D’Hooghe, Cristina Campoy, Bart C. Fauser, Lois A. Salamonsen, Andres Salumets. Guidelines for the design, analysis and interpretation of “omics” data: focus on human endometrium. Hum Reprod Update Vol.20, No.1 pp. 12-28, 2014

Fugrich DG, Lessey BA, Savaris RE. Comparison of HSCORE assessment of endometrial beta3 integrin subunit expression with digital HSCORE using computerized image analysis (ImageJ). Anal Quant Cytol Histol. 2013 Aug;35(4):210-6. PubMed PMID: 24341124

Oh SJ, Shin JH, Kim TH, Lee HS, Yoo JY, Ahn JY, Broaddus RR, Taketo MM, Lydon, JP, Leach RE, Lessey BA, Fazleabas AT, Lim JM, Jeong JW. B-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition. J Pthol. 2013 Oct; 231(2):210-22. doi: 10.1002/path.4224. PubMed PMID: 23784889.

Li X, Large MJ, Creighton CJ, Lanz, RB Jeong JW, Young SL, Lessey BA, Palomino WA, Tsai SY, Demayo FJ. COUP-TFII Regulates Human Endometrial Stromal Genes Involved in Inflammation. Mol Endocrinol. 2013 Oct 31. [Epub ahead of print] PubMed PIMI: 24176914.

Canny, GO, Lessey, BA, The Role of Lipoxin A4 in Endometrial Biology and Endometriosis. Mucosal Immunology, (13 March 2013) doi:10.1038, mi.2013.9

Lessey, BA, Higdon, HL, Miller, SE, Price, TA. Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity. J Vis Exp, 2012 Dec 21; 70.

26 Korch C, Spillman MA, Jackson TA, Jacobsen BM, Murphy SK, Lessey BA, Jordan VC, Bradford AP. DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination. Gynecol Oncol. 2012 Jun 16. [Epub ahead of print] PubMed PMID: 22710073.

Plante BJ, Lessey BA, Taylor RN, Wang W, Bagchi MK, Yuan L, Scotchie J, Fritz MA, Young SL. G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and Abnormal Endometrium. Reprod Sci. 2012 Jul;19(7):684-93.Epub 2012 Feb 28. PubMed PMID: 22378861.

Paul B. Miller, MD, Brent Parnell, MD, Greta Bushnell, Nicholas Tallman, David A. Forstein, DO, H. Lee Higdon, III, PhD Jo Kitawaki, MD, PhD, Bruce A. Lessey, MD, PhD, Endometrial Receptivity Defects During In Vitro Fertilization Cycles with and without Letrozole. Hum Reprod, In Press 2011 de Paula Guedes Neto E, Savaris RF, von Eye Corleta H, Silva de Moraes G, do Amaral Cristovam R, Lessey BA. Prospective, randomized comparison between raloxifene and clomiphene citrate for ovulation induction in polycystic ovary syndrome. Fertil Steril. September 2011 Savaris RF, Groll JM, Young SL, DeMayo FJ, Jeong JW, Hamilton AE, Giudice LC, Lessey BA. Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. J Clin EndocrinolMetab. 2011 Jun;96(6):1737-46. Epub 2011 Mar 16. PubMed PMID: 21411543 Brosens JJ, Hodgetts A, Feroze-Zaidi F, Sherwin JR, Fusi L, Salker MS, Higham J, Rose GL, Kajihara T, Young SL, Lessey BA, Henriet P, Langford PR, Fazleabas AT: Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis. Mol Hum Reprod. 2010 Apr;16(4):273-85. Epub 2009 Dec 14.PMID: 20008415 Groll JM, Usadi RS, Lessey BA, Lininger R, Young SL, Fritz MA. Effects of variations in serum estradiol concentrations on secretory endometrial development and function in experimentally induced cycles in normal women. Fertil Steril. 2009 Dec;92(6):2058-61. Burney RO, Hamilton AE, Aghajanova L, Vo KC, Nezhat CN, Lessey BA, Giudice LC. MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis. Mol Hum Reprod. 2009 Oct;15(10):625-31. Fassbender A, D'Hooghe T, Mihalyi A, Kyama C, Simsa P, Lessey BA. Plasma C3a-des-Arg levels in women with and without endometriosis. Am J Reprod Immunol. 2009 Sep;62(3). Scotchie JG, Fritz MA, Mocanu M, Lessey BA, Young SL. Proteomic analysis of the luteal endometrial secretome. Reprod Sci. 2009 Sep;16(9):883-93. Collins NH, Lessey EC, DuSell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing AM, Lessey BA. Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. Biol Reprod. 2009 Feb;80(2):375-83. Epub 2008 Oct 15. Erratum in: Biol Reprod. 2009 Jun;80(6):1306. Jeong JW, Lee HS, Lee KY, White LD, Broaddus RR, Zhang YW, Vande Woude GF, Giudice LC, Young SL, Lessey BA, Tsai SY, Lydon JP, DeMayo FJ. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8677-82. Jeonga JW, Leeb HS, Leea KY, Whitec LD, Broaddusd RR, Zhange YW, Vande Woudee GF, Giudicef LC, Young SL, Lessey BA, Tsaia SY, Lydona JP, and DeMayoa FJ. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease Proc Natl Acad Sci USA 05/09; 106(21): 8677–8682. Usadi RS, Groll JM, Lessey BA, Lininger RA, Zaino RJ, Fritz MA, Young SL. Endometrial development and function in experimentally induced luteal phase deficiency. J Clin Endocrinol Metab. 2008 Oct;93(10):4058-64. Savaris RF, Hamilton AE, Lessey BA, Giudice LC. Endometrial gene expression in early pregnancy: lessons from human ectopic pregnancy. Reprod Sci. 2008 Oct;15(8):797-816. Fassbender A, D'Hooghe T, Mihalyi A, Kyama C, Simsa P, Lessey BA, Plasma C3a-des-Arg levels in women with and without endometriosis. Fertil Steril 2008, 07.240

27 Collins NH, Lessey EC, DuSell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing AM, Lessey BA. Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. Biol Reprod 2009 Feb;80(2):375-83. Epub 2008 Oct 15 Sugihara K, Kabir-Salmani M, Byrne J, Wolf DP, Lessey BA, Iwashita M, Aoki D, Nakayama J, Fukuda MN. Induction of trophinin in human endometrial surface epithelia by CGbeta and IL-1beta. FEBS Lett. 2008 Jan 23;582(2):197-202. Usadi, RS, Groll, JM, Lessey, BA, Lininger R, Zaino R., Fritz, MA, Young, SL. Endometrial Development and Function in Experimentally-Induced Luteal Phase Deficiency. J Clin Endocrinol Metab 2008 Oct 93(10):4058-64. Epub 2008 Jul 22 Savaris, Ricardo, Hamilton, Amy, Lessey, BA, Giudice, Linda, Endometrial Gene Expression in Early Pregnancy: Lessons From Human Ectopic Pregnancy: Repro Scien Vo. doi: 10.177/1933719108317585. Bai, Suxia, Grossman, Gail, Yuan, Lingwen, Lessey BA, French, Frank S., Young, Steven L., Wilson, Elizabeth, Hormone Control and Androgen Receptor Coregulator Mage-11 in Human Endometrium During the Window of Receptivity to Embryo Implantation. Mol Hum Reprod 2008 14:107-16. Bohler HC., Gercel-Taylor C, Lessey BA, Taylor D, Endometriosis Markers: Immunologic Alterations as Diagnostic Indicators for Endometriosis: Repro Scien 2007 Vol. 14 No. 6, 595-604. Burney RO, Talbi S, Hamilton AE, Vo KC, Nyegaard M, Nezhat CR, Lessey BA, Guidice LC, Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis: Endocrinol. 2007 Aug; 148(8):3814-26. Epub 2007 May 18. MacLaughlin SD, Palomino WA, Bilan MO, Lewis TD, Lininger RA, Lessey, BA, Endometrial Expression of Cyr61, A Marker of Estrogenic Activity in Normal and Abnormal Endometrium, Obstel Gynecol, 2007 110:146-54. Braundmeier AG, Fazleabas AT, Lessey BA, Guo H, Toole BP, Nowak RA, Extracellular matrix metalloproteinase inducer regulates metalloproteinases in human uterine endometrium. J Clin Endocrinol Metab 2006 June;91(6):2358-65. Mo B, Vendrov WA, Palomino WA, DuPont BR, Appara, KBC, Lessey BA CC-1 Cells: A Well-Differentiated Steroid-Responsive Endometrial Cell Line with characteristics of Luminal Epithelium. 2006 Sept; Biol Reprod 75(3):387-94, Epub 2006, May 17. Carson DC, Julian J, Lessey BA, Prakobphol A, Fisher, S.J. MUCI Is a Scaffold for Selectin Ligands in the Human Uterus. Front in Bioscien 2006 11, 2903-2909. Lessey BA, Palomino WA, Apparao, KBC, Young SL, Lininger RA Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reprod Bio & Endocrinol. 2006, 4(Suppl 1):S9. Talbi ., Hamilton AE, V, KC, Tulac S, Overgaard MT, Dosiou C, Le Shay N, Nezhat CN, Kempson R, Lessey BA, Nayak NR, Giudice LC. Molecular phenotyping of human endometrium distinquishes menstrual cycle phases and underlying biological processes in normo- ovulatory women. Endocrinology. 2006 Mar;147(3):1097-121. Epub2005 Nov. 23. Miller PB, Forstein DA, Usadi RS, Lessey BA, Higdon III HL, Boone WR Assisted Reproductive Technology (ART) in the Upstate: Reducing the Risks of Multiple Births. J S C Med Assoc. 2005 Dec;101(11):373-7. Igarashi TM, Bruner-Tran KL, Yearma, GR, Lessey BA, Edwards EP, Eisenberg E, Osteen KG. Reduced Expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,9- tetrachlorodibenzo-p-dioxin. Fertil Steril 2005. 84:67-74. Lovely LP, Fazleabas AT, Fritz MA, Lessey BA Prevention of Endometrial Apoptosis: Randomized Prospective Comparison of hCG versus Progesterone Treatment in the Luteal Phase. J Clin Endocrinol Metab 2005, 90:2351-6. Murray M, Meyer WR, Zaino RJ, Lessey BA, Novotny DB, Ireland K, Zeng D, Fritz MA. A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril, 2004. 81(5): p. 1333-43. Haendler, B., Yamanouchi H, Lessey, BA, Chwalisz K, Hess-Stumpp, H. Cycle-dependent endometrial expression and hormonal regulation of the fibulin-1 gene. Molec Reprod Dev 2004, 68:279-287. Apparao, KBC, Illera MJ, Beyler SA, Olson GE, Osteen KG, Corjay MH, Kim Boggess K, Lessey BA Regulated expression of osteopontin in the peri-implantation rabbit uterus. Biol Reprod, 2003. 68 1484–1490

28 Illera MJ, Lorenzo PL, Yao-Ting G, Beyler SA, Apparao KC, Lessey BA A role for alphavbeta3 integrin during implantation in the rabbit model. Biol Reprod, 2003. 68(3): 766-71. Sagoskin AW, Lessey BA, Mottla GL, Richter KS, Chetkowski RJ, Chang AS, Levy MJ, Stillman RJ. Salpingectomy or proximal tubal occlusion of unilateral hydrosalpinx increases the potential for spontaneous pregnancy. Hum Reprod, 2003. 18(12): 2634-7. Tulac S, Nayak NR, Kao LC, van Waes M, Huang, Lobo JS, Germeyer A, Lessey BA, Taylor RN, Suchanek E and Giudice LC Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometrium. J Clin Endocrinol Metab, 2003. 88: 3860-3866. Murray MJ, Meyer WR, Lessey BA, Oi RH, DeWire RE, Fritz MA. Soy protein isolate with isoflavones does not prevent estradiol-induced Endometrial hyperplasia in postmenopausal women: A pilot study. J N A Menopause Soc 2003, 10:456-464. Kao LC, Germeyer A, Tulac S, Lobo S, Yang JP, Taylor RN, Osteen K, Lessey BA, Giudice LC. Expression Profiling Of Endometrium From Women With Endometriosis Reveals Candidate Genes For Disease-Based Implantation Failure And Infertility. Endocrinology, 2003; 144(7):2870-81. Usadi RS, Murray MJ, Bagnell RC, Fritz MA, Kowalik AI, Meyer WR, Lessey BA. Temporal and morphologic characteristics of pinopod expression across the secretory phase of the endometrial cycle in normally cycling women with proven fertility. Fert Steril 2003 79:970-4. Apparao KBC, Illera MJ, Beyler SA, Olson GE, Osteen KG, Corjay MH, Boggess K, Lessey BA. Regulated expression of osteopontin in the prei-implantation rabbit uterus. Biol Reprod 2003, 68:1484-90. Illera MJ, Lorenzo PL, Gui YT, Beyler SA, Apparao KBC, Lessey BA. A role for ανβ3 during implantation in the rabbit model. Biol Reprod 2003. 68:766-771. Lessey BA, Two pathways of progesterone action in the human endometrium: implications for implantation and contraception. Steroids, 2003. 68(10-13): p. 809-15. Khorram O, Lessey BA. Alterations in expression of endometrial endothelial nitric oxide synthase and alpha(v)beta(3) integrin in women with endometriosis. Fertil Steril 2002; 78(4):860-4. Carson DD, Lagow E, Thathiah A, Al-Shami R, Farach-Carson MC, Vernon M, Yuan L, Fritz MA, Lessey BA. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod 2002 8(9):871-9. Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A, Osteen K, Taylor RN, Lessey BA, Giudice LC. Global gene profiling in human endometrium during the window of implantation. Endocrinology 2002 143(6):2119-38. Lessey BA, Gui Y, Apparao KB, Young SL, Mulholland J. Regulated expression of heparin-binding EGF-like growth factor (HB-EGF) in the human endometrium: a potential paracrine role during implantation. Mol Reprod Dev 2002 62(4):446-55. Gregory CW, Wilson EM, Apparao KB, Lininger RA, Meyer WR, Kowalik A, Fritz MA, Lessey BA. Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium. J Clin Endocrinol Metab 2002;87(6):2960-6. Young SL, Murray MJ, Nagamani M, Nowicki BJ, Lessey BA: Luteal expression of human endometrial decay accellerating factor (DAF): Evidence for regulation by Heparin-binding Epidermal Growth Factor (HB-EGF) J Clin Endocrinol Metab 2002;87:1368-75. Arnold JT, Lessey BA, Seppälä MT, Kaufman DG. Effect of normal endometrial stroma on growth and differentiation in Ishikawa endometrial adenocarcinoma cells. Cancer Res 2002, 62:79-88. Apparao KBC, Lovely LP, Gui Y. Lessey BA Elevated Endometrial Androgen Receptor Expression in Women with Polycystic Ovarian Syndrome (PCOS). Biol Reprod 2002; 66(2):297-304. Damario MA, Lesnick TG, Lessey BA, Kowalik, A., Mandelin E, Seppälä M, Rosenwaks Z. Endometrial markers of uterine receptivity utilizing the donor oocyte model. Hum Reprod, 2001, 16:1893-1899. Arnold JT, Kaufman DG, Seppälä M, Lessey BA. Endometrial stromal cells regulate epithelial cell growth in vitro: A new co-cultural model. Hum Reprod, 2001 16:836-845.

29 Williams CD, Boggess JF, LaMarque R. Meyer WR, Murray MJ, Fritz, MA, Lessey BA. A prospective, randomized study of endometrial telomerase during the menstrual cycle. J Clin Endcrinol Metab 2001, 86: 3912-3917. Apparao KBC, Chambers AF, Murray MJ, Fritz MA, Meyer WR, Lessey BA. Osteopontin and its receptor ανβ3 integrin are co- expressed in the human endometrium during the menstrual cycle but regulated differentially. J Clin Endocrinol Metab 2001, 86:4991- 5000. Lovely LP, Appa-Rao KBC, Gui Y and Lessey BA. Characterization of the androgen receptor in a well-differentiated endometrial adenocarcinoma cell line (Ishikawa). J Steroid Biochem Mol Biol ,2000 74 (4)235-41. Allaire AD, D'Andrea N, Truong P, McMahon MJ, Lessey BA. Cervical stroma apoptosis in pregnancy. Obstet Gynecol 2001; 97(3):399- 403. Illera MJ, Cullinan E, Gui Y, Yuan L, Beyler SA, Lessey BA. Blockade of the alpha(v)beta(3) integrin adversely affects implantation in the mouse. Biol Reprod 2000;62(5):1285-90 Illera MJ, Yuan L, Stewart CL, Cullinan E and Lessey BA Effect of peritoneal fluid from women with endometriosis on implantation in the mouse model. Fertil Steril, 2000 74:41-48 Lessey BA Medical management of endometriosis and infertility. Fertil Steril. 73:1089-96, 2000. Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstet Gynecol 2000; 96(2):271-6. Tabibzadeh S, Mason JM, Shea W, Cai Y, Murray MJ, Lessey BA. Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility. J Clin Endocrinol Metab 2000; 85(7):2526-36. Lessey BA, Castelbaum AJ, Wolf L, Greene W, Paulson M, Meyer WR, Fritz MA. Use of integrins to date the endometrium. Fertil Steril 2000;73(4):779-87. Gui Y, Zhang J, Yuan L, Lessey BA. Regulation of HOXA-10 and its expression in normal and abnormal endometrium. Mol Hum Reprod 1999;5(9):866-73. Murray MJ, Zhang J, Lessey BA. Expression of alpha6 and beta4 integrin subunits throughout the menstrual cycle: no correlation with uterine receptivity. Fertil Steril 1999;72(3):522-6. Harrington DJ, Lessey, BA, Rai V, Bergqvist A, Kennedy S, Barlow DH, Mardon HJ. Tenascin is differentially expressed in endometrium and endometriosis. J. Pathol, 1999 187(2):242-8. Meyer WR, Novotny DB, Fritz MA, Beyler SA, Wolf LJ, Lessey BA. The Effect of Exogenous Gonadotropins on Endometrial Maturation in Oocyte Donors. Fertil Steril, 1999;71(1):109-14. Tabibzadeh S, Lessey,BA, Satyaswaroop,PG. Temporal and site-specific expression of TGF-ß4 in human endometrium: Expression of TGF-ß4 in endometrium. Mol Hum Reprod, 1998; 4 (6) 595-602. Rodriguez GC, Walmer D, Cline M, Krigman H, Lessey BA, Whitaker R, Dodge R, Hughe, Cl. Effect of Contraceptive Progestins on the Ovarian Epithelium: Cancer Prevention Through Apoptosis? J Soc Gynecol Invest, 1998 5:271-276. Somkuti SG, Yuan L, Fritz MA, Lessey BA. Epidermal Growth Factor and Sex Steroids Dynamically Regulate a Marker of Endometrial Receptivity in Ishikawa Cells. J Clin Endcrinol Metab, 1997; 82: 2192-97. Meyer WR, Castelbaum AJ, Somkuti S, Sagoskin AW, Doyle M, Harris JE, Lessey BA. Hydrosalpinges Adversely Affect Markers of Endometrial Receptivity. Hum Reprod, 1997; 12:1393-98. Fazleabas A, Bell S, Fleming S, Sun J, Lessey BA. Distribution of Integrins and the Extracellular Matrix Proteins in the Baboon Endometrium During the Menstrual Cycle and Early Pregnancy. Biol Reprod 1997 56:348-356. Castelbaum AJ, Ying L, Somkuti SG, Sun J, Ilesanmi AO, Lessey, BA. Characterization of Integrin Expression in a Well Differentiated Endometrial Adenocarcinoma Cell Line (Ishikawa). J Clin Endocrinol Metab 1997 82:136-142. Lessey BA, Ilesanmi AO, Castelbaum AJ, Yuan L, Somkuti SG, Chwalisz K, Satyaswaroop, PG. Characterization of a Functional Progesterone Receptor in a Well-Differentiated Endometrial Adenocarcinoma Cell Line (Ishikawa). J Steroid Biochem Mol Biol, 1996 59:31-39.

30 Cullinan EB, Abbondanzo SJ, Anderson PA, Pollard JW, Lessey BA, Stewart CL. Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggest a potential autocrine/paracrine function in regulating embryo implantation. Proc Natl Acad Sci USA, 1996 93:3115-3120. Lessey BA, Yeh I-t, Castelbaum AJ, Fritz MA, Ilesanmi AO, Korzeniowski P, Sun J, Chwalisz. Endometrial Progesterone Receptors and Markers of Uterine Receptivity in the Window of Implantation. Fertil Steril 1996 65:477-483. Lessey BA, Ilesanmi AO, Lessey MA, Riben M, Harris JE and Chawlisz K. Luminal and glandular endometrial epithelium express integrins differentially throughout the menstrual cycle: Implications for implantation, contraception, and infertility. Am J Reprod Immunol, 1996 35: 195-204. Grosskinsky CM, Yowell CW, Sun J, Parise L, Lessey BA. Modulation of integrin expression in endometrial stromal cells in vitro. J Clin Endocrinol Metab 1996 81: 2047-2054. Somkuti SG, Yowell CW, Lessey BA. The effect of oral contraceptive pills on markers of endometrial receptivity. Fertil Steril 1996 65:484-488. Krasnow JS, Lessey BA, Nuns G, Hall LN, Guzick DS, Berga S. Comparison of transdermal versus oral estradiol on endometrial receptivity. Fertil Steril1995 65:332-336. Castelbaum AJ, Sawin SW, Bellardo LJ, Lessey BA. Endometrial integrin expression in women exposed to diethylstilbestrol in utero. Fertil Steril 1995 63:1217-1221. Lessey BA, Albelda S, Buck CA, Castelbaum AJ, Yeh I, Kohler M, Berchuck A. Distribution of Integrin Cell Adhesion Molecules in Endometrial Cancer. Am J Pathol 1995 146:717-726. Sayegh R, Awwad JT, Maxwell C, Lessey BA, Isaacson K. Alpha-2 macroglobulin (A2M) production by the human endometrium. J Clin Endocrinol Metab 80:1021-1026, 1995 Lessey BA, Castelbaum AJ, Sawin SW, Sun J. Integrins as markers of uterine receptivity in women with primary unexplained infertility. Fertil Steril 1995 63:535-542. Wittmaack FM, Blasco L, Mastroianni L, Kreger DO, Tureck RW, Lessey BA. Effect of follicular size on oocyte retrieval, fertilization, cleavage, and embryo quality in vitro fertilization cycles: A six year data collection. Fertil Steril 1994 62:1205-1210. Lessey BA, Castelbaum AJ, Buck CA, Sawin SW, Schinnar R, Bilker W, Strom BL. Aberrant integrin expression in the endometrium of women with endometriosis. J Clin Endocrinol Metab 79:643-649, 1994 Lessey BA, Castelbaum AJ, Buck CA, Ying L, Yowell CW, Sun J. Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril 1994 62:497-506. Hasty LA, Lambris JD, Lessey BA, Pruksananonda K, Lyttle CR. Hormonal regulation of complement components and receptors throughout the menstrual cycle. Am J Obstet Gynecol 1994 170:168-175. Castelbaum AJ, Wheeler J, Coutifaris C, Mastroianni L and Lessey BA. Timing of the endometrial biopsy may be critical for the accurate diagnosis of luteal phase deficiency. Fertil Steril 1994 61:443-447. Lessey BA and J. Ander Pindzola. Tumor associated glycoprotein, TAG-72 in endometriotic implants. J Clin Endocrinol Metab 1993 76:1075-1079. Lessey BA, Damjanovich L, Coutifaris C, Castelbaum A, Albelda SM, Buck CA. Integrin adhesion molecules in the human endometrium: Correlation with the normal and abnormal menstrual cycle. J Clin Invest 1992 90:188-195. Metzger DA, Lessey BA, Soper, JT, McCarty, KS, Haney AF. Hormone-resistant endometriosis following total abdominal hysterectomy and bilateral salpingo-oophorectomy: Correlation with histology and steroid receptor content. Obstet Gynecol 1991 78:946-950. Soisson AP, Berchuck A, Lessey BA, Soper JT, Clarke-Pearson DC, McCarty KS, Jr., Bast RC, Jr. Immunohistochemical expression of TAG-72 in normal and malignant endometrium: Correlation of antigen expression with estrogen and progesterone receptor levels. Am J Obstet Gynecol 1989 161:1258-1263.

31 Lessey BA, Metzger DA, Haney AF, McCarty Jr. KS, Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: Comparison with normal endometrium during the menstrual cycle and the effect of medical therapy. Fertil Steril 1989 51:409-415. Lessey BA, Killam AP, Metzger DA, Haney AF, and McCarty KS, Jr. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab 1988 67:334-340. Lessey BA, Alexander S, Horwitz KB. The subunit structure of human breast cancer progesterone receptor: Characterization by chromatography and photoaffinity labeling. Endocrinology 1983 112:1267-74. Horwitz KB, Mockus MB, Lessey BA. Variant T47D human breast cancer cells with high progesterone receptor levels despite estrogen and anti-estrogen resistance. Cell 1982 28:633-642. Mockus MB, Lessey BA, Bower MA, Horwitz KB. Estrogen-insensitive progesterone receptors in a human breast cancer cell line: Characterization of receptors and a ligand exchange assay. Endocrinology 1982 110:1564-71. Lessey BA, Wahawisan R, Gorell TA. Hormonal regulation of cytoplasmic estrogen and progesterone receptors in the beagle uterus and oviduct. Mol Cell Endocrinol 1981 21:171-80. Lessey BA, Gorell TA. Nuclear progesterone receptors in the beagle uterus. J Steroid Biochem 1981 15:585-91. Lessey BA, Gorell TA. Analysis of progesterone receptors in the beagle uterus and oviduct. J Steroid Biochem 1980 13:1173-80. Lessey BA, Gorell TA. A cytoplasmic estradiol receptor in the immature beagle uterus. J Steroid Biochem 1980 13:211-7.

Chapters in Scholarly Books and Monographs: Non Peer Reviewed:

Fox C, Morin S, Jeong JW, Scott RT Jr, Lessey BA. Local and systemic factors and implantation: what is the evidence? Fertil Steril. 2016 Apr;105(4):873-84. doi: 10.1016/j.fertnstert.2016.02.018. Epub 2016 Mar 3. Review. PubMed PMID: 26945096

Szwarc MM, Kommagani R, Lessey BA, Lydon JP. The p160/Steriod Receptor Coactivator Family: Potent Arbiters of Uterine Physiology and Dysfunction. Biol Reprod. 2014 Oct 8. pii: biolreprod.114.125021. PMID: 25297546 Lessey, BA. Endometrial Assessment: A Clinical Guide. Womens Health (Lond Engl). 2013 Sep; 9(5):415-7. doi: 10.2217/whe.13.43. PubMed PMID: 24007244. Lessey, BA, Lebovic, DL, Taylor, RN. Eutopic Endometrium in Women with Endometriosis: Ground Zero for the Study of Implantation Defects. Semin Reprod Med 2013; 31:109-124. Lessey, BA, The pathologists are free to go, or are they? Fertil Steril 2012 Dec 13 Lessey BA and Young SL. Chapter 23: Pathophysiology of Infertility in Endometriosis. Pg 240-254. Endometriosis Science and Practice, Eds Giudice LC, Evers JLH, Healy DL, 1st Edition. Blackwell Publishing, Ltd, Oxford, UK. 2012. Lessey BA, Assessement of endometrial receptivity, Fertility and Sterility, September 2011 Patel, BG.and Lessey BA. Clinical assessment and management of the Endometrium in recurrent pregnancy loss, Seminars in Reproductive Medicine, in press, 2011 Holoch KJ, Lessey BA. Endometriosis and infertility. Clin Obstet Gynecol. 2010Jun;53(2):429-38. PubMed PMID: 20436320. Lessey BA. Fine tuning of endometrial function by estrogen and progesterone through microRNAs. Biol Reprod. 2010 Apr;82(4):653-5. Epub 2010 Feb 3. PMID: 20130265. Young SL, Lessey BA. Progesterone function in human endometrium: clinical perspectives. Semin Reprod Med. 2010 Jan;28(1):5-16. Epub 2010 Jan 26. Review. PMID: 20104424. Holoch KJ, Lessey BA. Clinical assessment of the endometrium. Early Pregnancy 2010 Eds Farquharson RG, Stephenson MD. Cambridge Press, Cambridge England, Chapter 18, pp 171-98. Strauss III JF and Lessey BA. Chapter 9: The Structure, Function and Evaluation of the Female Reproductive Tract. Pg 191-233. Yen & Jaffe’s Reproductive Endocrinology, 6th Edition. Eds: Strauss, J.F., III and Barbieri, Elsevier, Inc. 2009 6th Edition.

32 Giudice LC, and Lessey BA, Chapter 45: The Endometrium of Polycystic Ovary Syndrome. Pg. 683-690. In The Endometrium. Eds Aplin, JDu Giudice LC, Fazleabas, A. 2nd Edition. Taylor and Francis Publishers, New York NY. 2008. Lessey BA, and Glasser S. Chapter 20: Endometrial Receptivity. Pg 305-318. In The Endometrium. Eds Aplin, J.D.u, Giudice, L.C., Fazleabas, A, 2nd Edition. Taylor and Francis Publishers, New York, NY. 2008. Giudice LC, Talbi S, Hamilton A, and Lessey BA, Chapter 14:The Endometrial Transcriptome. In The Endometrium. Pg 193-222. Eds Aplin, J. D., Giudice, L.C. Fazleabas, A., 2nd Edition. Taylor and Francis Publishers, New York, NY. 2008. Donaghay MS, and Lessey BA - Uterine Receptivity: Alternations Associated with Benign Gynecological Disease. Seminars in Reproductive Medicine, Thieme Inc 2007 25:461-475. Lessey BA, Chetkowski RJ, Detecting differences in endometrial maturation? Fertil Steril. 2005 Feb;83(2):519; author reply 519-20. Strauss III JF and Lessey BA The Structure, Function and Evaluation of the Female Reproductive Tract. Yen & Jaffe’s Reproductive Endocrinology, 5th Edition. Eds: Strauss, J.F., III and Barbieri, R.L. Elsevier, Inc. 2004, Chap. 9, pp 255-305. Lessey BA Endometrial responsiveness to steroid hormones: A moving target. J. Soc. Gynecol. Invest. 2004. 11: 61-62. Seppala M and Lessey BA Determination of endometrial status and the implantation window. Essential IVF: Basic Research and Clinical Applications. Eds Van Blerkom J, Gregory L. Kluwer Academic Publishers, Boston, MA. 2004. Chap. 21, pp 577-609. Lessey BA, Vendrov, A.E., Yuan, L. Endometrial cancer cells as models to study uterine receptivity. Cell and Molecular Biology of Endometrial Carcinoma. Eds Kuramoto H, and Nishida, M. Springer, Tokyo, Japan. 9: 267-279, 2003. Lessey BA The Endometrium Chapter. The Endometrium. Eds. Glasser SR, Aplin JD, Giudice, LC, and Tabibzadeh S. 1st. Edition. Taylor and Francis Publishers, New York, NY. 2002. Lessey BA Uterine markers and embryo implantation. Advances in Infertility Treatment. Ed: M. Filicori. Monduzzi Editore, Bologna, Italy. 225-243. 2002. Lessey BA and Castelbaum, A.J. Integrins and implantation in the human. Rev. Endocrine and Metab Disorders, 3:107-117, 2002. Lessey BA Implantation defects in women with endometriosis. Ann N Y Acad Sci. 955:265-80; discussion 293-5, 396-406, 2002. Lessey BA The use of biomarkers for the assessment of uterine receptivity. Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives. Eds: Gardner, D.K., Weissman, A, Howles, C.M., and Shoham, Z. Martin Dunitz, London. Chapter 29, 353- 366, 2001. Lessey BA Biomarkers and the Assessment of Uterine Receptivity. ART and the Human Blastocyst. Eds: Gardner D.K., and Lane, M. Serono Symposia, Springer-Verlag, New York, NY. Ch. 17: 210-226, 2001. Carson DD, Bagchi I, Dey SK, Enders AC, Fazleabas AT, Lessey BA, Yoshinaga K. Embryo implantation. Dev Biol. 223:217-37, 2000. Lessey BA Endometrial Receptivity and the window of implantation. Bailliere’s Clinical Obstetrics and Gynecology, 14:775-788, 2000. Lessey BA and Lovely LP. Implantation. Handbook of the Assisted Reproduction Laboratory. Eds Keel, BA, May, J.V., De Jonge, C.J. CRC Press, Boca Raton, FL. Ch. 3; 33-76, 2000. Lessey BA. The role of the endometrium during embryo implantation. Hum Reprod. 2000 Suppl 6:39-50, 2000. Fritz MA and Lessey BA Defective Luteal Phase. Estrogens and Progestogens in Clinical Practice. Eds: Fraser, I.S., Jensen, R.P.S., Lobo, RA, Whitehead MI. Elsevier, 1999. Murray MJ and Lessey BA Embryo implantation and tumor metastasis: Common pathways of invasion and angiogenesis. Semin Reprod Endocrinology, 17,275-290, 1999. Tabibzadeh S, Shea W, Lessey BA, Broome, J. From endometrial receptivity to Infertility. Seminar Reprod Endocrinol 17:197-203, 1999. Castelbaum AJ, Freedman MF, Platia MP, Lessey BA. Therapy of endometriosis--avoidance of confounders! Fertil Steril, 69:360-1, 1998. Lessey BA Arnold JT. Paracrine signaling in the endometrium: Integrins and the establishment of uterine receptivity. Journal of Reproductive Immunology, 39, pp 105-116, 1998. Lessey BA Embryo quality and endometrial receptivity: lessons learned from the ART experience. J Assist Reprod Genet. 15:173-6, 1998. Lessey BA Endometrial integrins and the establishment of uterine receptivity. Human Reproduction, vol. 13, pp 247-258, 1998.

33 Castelbaum AJ, Freedman MF, Platia MP, Lessey BA. Therapy of Endometriosis - Avoidance of Confounders. Letters-to-the-editor, Fertility and Sterility, vol. 69, number 2: 360-361, 1998. Lessey BA, Castelbaum AJ. Integrins and endometriosis: fact or artefact? Hum Reprod. 13:3578-80, 1998. Lessey BA, Integrins and the Endometrium: New Markers of Uterine Receptivity. The Uterus Endometrrium and Myometrium, Annals of the New York Academy of Sciences, vol. 828, pp 111-122, 1997. Meyer WR, Lessey BA, Castelbaum AJ. Hydrosalpinx and Altered Uterine Receptivity. Letters-to-the-editor, Fertility and Sterility, vol. 68, number 5: 944, 1997. Lessey BA and Young SL. Integrins and other cell adhesion molecules in endometrium and endometriosis. Seminars in Reproductive Endocrinology. David Adamson (ed). Thieme Press. New York, vol.15, number 3: 291-299, 1997. Lessey BA, Sun J and Harris JE. Endometriosis and infertility: insights using integrins as markers of uterine receptivity. H. Minaguchi and O. Sugimoto (eds.), Proceedings of the 5th World Congress on Endometriosis. Endometriosis Today: advances in research and practice. Parthenon Publishing, 1997. Lessey BA and Young SL. Integrins in Endometrium and Endometriosis. Diamond and Osteen (eds.), Endometrium and Endometriosis. Eds, Diamond M.P. and Osteen, K.G. Blackwell Science. Oxford, England. 1997Chapter 16:p121-130. Lessey BA, Castlebaum AJ, Somkuti SG, Yuan L, Chwalisz K. Clinical significance of integrin cell adhesion molecules as markers of endometrial receptivity. Beier H, Chwalisz K (eds.), The Endometrium as a Target for Contraception. Berlin: Schering Press. 10:p193- 222, 1996. Lessey BA. Integrins and the implantation site. Jauniaux E, Barnea E, Edwards RE (eds.), Embryonic Medicine and Therapy. Oxford: Oxford University Press. in press, 1996. Castelbaum AJ, Lessey BA. Corpus luteum defect--"alloyed gold standard". Fertil Steril. Feb;63:427-8, 1995. Lessey BA. The changing pattern of integrin expression in human endometrium throughout the menstrual cycle and in early pregnancy. Leucocyte Typing V. White Cell Differentiation Antigens. Vol. 2. Oxford Press. AS6.17:p 1644-1646, 1995. Lessey BA. Integrins and reproduction revisited. Eur J Obstet Gynecol Reprod Biol. 62:264-5, 1995 Lessey BA. Endometrial Integrins. The Endocrinologist. 5:214-221, 1995. Lessey BA. Castelbaum AJ. Integrins in the endometrium of women with endometriosis. Brit. J. Obstet. Gynecol. (Correspondence) 102:347-348, 1995. Lessey BA. Castelbaum AJ. Integrins in the Endometrium, Reproductive Medicine Review, Edward Arnold Pub Ltd. 4:43-58, 1995. Somkuti S, Appenzeller M, Lessey BA. Advances in the Assessment of Endometrial Function, Infertility and Reproductive Medicine Clinics of North America, W. B. Saunders Co., vol. 6, number 2:303-328, 1995. Castelbaum AJ, Lessey BA. Insights into the Evaluation of the Luteal Phase, Infertility and Reproductive Medicine Clinics of North America, WB Saunders Co., vol. 6, number 1:199-213, 1995. Lessey BA. The use of integrins for the assessment of uterine receptivity. Fertil Steril, 61:812-814. Lessey BA. Editor's: corner: The use of integrins for the assessment of uterine receptivity. Fertil Steril 61:812-814, 1994. Ilesanmi AG, Hawkins DA, and Lessey BA. Immunohistochemical markers of uterine receptivity in the human endometrium. Micro Res Tech 25:208-222, 1993. Lessey BA. Integrins and assisted reproduction. Assisted Reproduction Reviews 3:56-62, 1993. Dunton CJ, Lessey BA, Mikuta JJ. Steroid receptors in gynecologic malignancies. Postgraduate Obstetrics & Gynecology 9:1, 1989.

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