WHO International Biological Reference Preparations Held and Distributed by the WHO International Laboratories for Biological Standards PREPARATION STANDARD MATERIAL HELD AT CODE WHO/BS DOCUMENT

http://whqlibdoc.who.int/hq/2007/WHO_BS_07.2073_eng.pdf http://whqlibdoc.who.int/hq/2007/WHO_BS_07.2073_eng.pdf Amphotericin B, Lyophilized, 944 IU / mg. Approximately 100 mg 2nd International Standard, 2007 EDQM ISA_29078 07.2073 http://whqlibdoc.who.int/hq/2007/WHO_BS_07.2073_eng.pdf http://whqlibdoc.who.int/hq/2007/WHO_BS_07.2073_eng.pdf of Amphotericin B.

Bacitracin, Lyophilized, Approximately 100 mg of zinc 2nd International Standard, 1964 Antibiotic EDQM 62/003 64.681 (74 IU / mg).

http://apps.who.int/iris/bitstream/10665/137469/1/WHO_BS_2014.2236_eng.pdf http://apps.who.int/iris/bitstream/10665/137469/1/WHO_BS_2014.2236_eng.pdf Bleomycin Complex A2/B2, Lyophilized, 12 500 IU/vial 2nd International Standard, 2014 Antibiotic EDQM ISA_46290 2014.2236 http://apps.who.int/iris/bitstream/10665/137469/1/WHO_BS_2014.2236_eng.pdf http://apps.who.int/iris/bitstream/10665/137469/1/WHO_BS_2014.2236_eng.pdf

Bleomycin complex A2/B2, Lyophilized, 8,910 IU / ampoule. 1st International Reference Antibiotic EDQM 78/547 80.1276 Preparation, 1980

Colistin, Lyophilized, 20,500 IU / mg. Approximately 75 mg of 1st International Standard, 1968 Antibiotic EDQM 65/062 68.923 sulfate.

Colistin methane sulfonate, Lyophilized, 12,700 IU / mg. 1st International Reference Antibiotic EDQM 66/254 68.924 Approximately 75 mg of colistin methane sulfonate. Preparation, 1968

http://whqlibdoc.who.int/hq/2011/WHO_BS_2011.2176_eng.pdf http://whqlibdoc.who.int/hq/2011/WHO_BS_2011.2176_eng.pdf Dihydrostreptomycin, Lyophilized, 19,425 IU/vial. 3rd International Standard, 2011 Antibiotic EDQM ISA_42688 2011.2176 http://whqlibdoc.who.int/hq/2011/WHO_BS_2011.2176_eng.pdf http://whqlibdoc.who.int/hq/2011/WHO_BS_2011.2176_eng.pdf

Erythromycin, Lyophilized, 920 IU / mg. Approximately 75 mg of 2nd International Standard, 1978 Antibiotic EDQM 76/538 78.1228 erythromycin A base.

Gentamicin, Lyophilized, 31,020 IU / ampoule. 2nd International Standard, 1995 Antibiotic EDQM 92/670 95.1811

Gramicidin, Lyophilized, 1,070 IU / mg. Approximately 100 mg of 2nd International Standard, 2008 Antibiotic EDQM ISA_28168 08.2100 Gramicidin.

WHO-BS-2017.2323-eng.pdf WHO-BS-2017.2323-eng.pdf WHO-BS-2017.2323-eng.pdf WHO-BS-2017.2323-eng.pdf

Kanamycin, Lyophilized, 10,345 IU / ampoule. 1st International Standard, 1986 Antibiotic EDQM 83/521 86.1515

http://www.who.int/iris/bitstream/10665/96550/1/WHO_BS_2012.2202_eng.pdf http://www.who.int/iris/bitstream/10665/96550/1/WHO_BS_2012.2202_eng.pdf , Lyophilized, Anti-microbiological activity of 19 050 IU / 3rd International Standard, 2012 Antibiotic EDQM ISA/011 2012.2202 http://www.who.int/iris/bitstream/10665/96550/1/WHO_BS_2012.2202_eng.pdf http://www.who.int/iris/bitstream/10665/96550/1/WHO_BS_2012.2202_eng.pdf vial

http://www.who.int/iris/bitstream/10665/96578/1/WHO_BS_2012.2201_eng.pdf http://www.who.int/iris/bitstream/10665/96578/1/WHO_BS_2012.2201_eng.pdf Neomycin B, Lyophilized, Anti-microbiological activity of 17 640 IU 2nd International Standard, 2012 Antibiotic EDQM ISA/46104 2012.2201 http://www.who.int/iris/bitstream/10665/96578/1/WHO_BS_2012.2201_eng.pdf http://www.who.int/iris/bitstream/10665/96578/1/WHO_BS_2012.2201_eng.pdf / vial

Netilmicin, Lyophilized, 4,810 IU / ampoule. 1st International Standard, 1989 Antibiotic EDQM 83/577 89.1628

http://whqlibdoc.who.int/hq/2007/WHO_BS_07.2072_eng.pdf http://whqlibdoc.who.int/hq/2007/WHO_BS_07.2072_eng.pdf Nystatin, Lyophilized, 5710 IU / mg. Approximately 100 mg of 3rd International Standard, 2007 Antibiotic EDQM ISA_29384 07.2072 http://whqlibdoc.who.int/hq/2007/WHO_BS_07.2072_eng.pdf http://whqlibdoc.who.int/hq/2007/WHO_BS_07.2072_eng.pdf Nystatin

Polymyxin B, , 8,403 IU / mg. Approximately 75 mg of purified 2nd International Standard, 1969 Antibiotic EDQM 67/301 69.990 B sulfate.

Rifamycin SV, Lyophilized, 887 IU / mg. Approximately 100 mg of 1st International Reference Antibiotic EDQM 66/231 67.885 Rifamycin SV. Preparation, 1967 30 March 2018 This Catalogue is available at the following WHO Web site address: http://www.who.int/bloodproducts/ref_materials/ Page 1 of 2 ANTIBIOTICS PREPARATION STANDARD MATERIAL HELD AT CODE WHO/BS DOCUMENT

Sisomicin, Lyophilized, 35,200 IU / ampoule. 1st International Standard, 1984 Antibiotic EDQM 80/543 84.1434

Spiramycin, Lyophilized, 3,200 IU / mg. Approximately 50 mg. 1st International Reference Antibiotic EDQM 62/008 64.692 Preparation, 1964

Streptomycin, Lyophilized, 78,500 IU / ampoule. 3rd International Standard, 1980 Antibiotic EDQM 76/539 80.1273

http://apps.who.int/iris/bitstream/10665/204483/1/WHO_BS_2015.2277_eng.pdf http://apps.who.int/iris/bitstream/10665/204483/1/WHO_BS_2015.2277_eng.pdf Streptomycin, Lyophilized., 76 000 IU/vial 4th International Standard, 2015 Antibiotic EDQM ISA55821 2015.2277 http://apps.who.int/iris/bitstream/10665/204483/1/WHO_BS_2015.2277_eng.pdf http://apps.who.int/iris/bitstream/10665/204483/1/WHO_BS_2015.2277_eng.pdf

Teicoplanin, Lyophilized, 51,550 IU / ampoule. 1st International Standard, 1990 Antibiotic EDQM 90/704 90.1642

Tobramycin, Lyophilized, 9,800 IU / ampoule. 2nd International Standard, 1985 Antibiotic EDQM 82/510 85.1504

http://whqlibdoc.who.int/hq/2010/WHO_BS_10.2151_eng.pdf http://whqlibdoc.who.int/hq/2010/WHO_BS_10.2151_eng.pdf , Lyophilized, 109,700 IU per vial 2nd International Standard, 2010 Antibiotic EDQM ISA 39036 10.2151 http://whqlibdoc.who.int/hq/2010/WHO_BS_10.2151_eng.pdf http://whqlibdoc.who.int/hq/2010/WHO_BS_10.2151_eng.pdf

30 March 2018 This Catalogue is available at the following WHO Web site address: http://www.who.int/bloodproducts/ref_materials/ Page 2 of 2