ACTL7A Antibody Cat. No.: 55-197

ACTL7A Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY:

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Monkey

This ACTL7A antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 41-67 amino acids from the N-terminal region of human ACTL7A.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 49 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

September 25, 2021 1 https://www.prosci-inc.com/actl7a-antibody-55-197.html CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: ACTL7A

ALTERNATE NAMES: -like protein 7A, Actin-like-7-alpha, ACTL7A

ACCESSION NO.: Q9Y615

PROTEIN GI NO.: 27923725

GENE ID: 10881

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

ACTL7A is a member of a family of actin-related (ARPs) which share significant sequence identity to conventional . Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. ACTL7A (ACTL7A), and related , ACTL7B, are intronless, BACKGROUND: and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.

REFERENCES: 1) Aberg, K., et al. Hum. Biol. 80(2):99-123(2008)

2) Humphray, S.J., et al. Nature 429(6990):369-374(2004)

3) Garvalov, B.K., et al. J. Biol. 161(1):33-39(2003)

4) Coutts, A.S., et al. J. Cell. Sci. 116 (PT 5), 897-906 (2003) :

ANTIBODIES FOR RESEARCH USE ONLY.

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