Int.J.Curr.Microbiol.App.Sci (2018) Special Issue-7: 5125-5126

International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Special Issue-7 pp. 5125-5126 Journal homepage: http://www.ijcmas.com

Case Study

Therapeutic Management of Concurrent Infection of Theileriosis and Amphistomiasis in a Cow

Swati Sahay1* and S. Kashi2

1Department of Veterinary Medicine,Ranchi,Veterinary college,Kanke,Ranchi-6, India 2Department of Husbandary, Jharkhand *Corresponding author

ABSTRACT

A cross bred cow was presented with a history of pyrexia, , K e yw or ds progressive weakness and fall in yield. On the basis of clinical

Theileria, examination and hematology, the case was diagnosed as mixed infection of Amphistomiasis, Primaquin theileriosis and amphistomiasis. The animal responded to therapy of primaquin, oxytetracycline and oxyclozanide.

Introduction

Tropical theileriosis, a tick born haemo- 1987). However the drug is expensive and protozoan caused by Theileria there are limitations regarding it’s annulata is one of the devastating disease availability for widespread use under rural affecting and buffaloes (Hasnapour et conditions. Under these circumstances, a al. 2008). It is estimated that 250 million combined therapy using tetracycline, cattle in countries like India, Iran and china antimalarials and antipyretics may be are at a risk of this disease casing serious employed to develop and economic economic concern through morbidity, sustainable treatment protocol for treatment mortality and production losses. The disease of theileriosis in both urban and rural areas. is characterized by high , lymph node The present paper puts on record of a mixed enlargement, anaemia, petechiae of infection of thicleria and amphistomiasis membrane and varying degree of jaundice. along with its successful management with primaquin, oxytetracyline and oxyclozanide. Drugs such as tetracycline, halofuginone, primaquin, paravaquone and buparvaquone Case history and observations (Butalex) have been used for the treatment of clinical theileriosis. Buparvaquone is the A four year old cross bred cow was most effective and safe drug with an overall presented to the Teaching Veterinary cure rate of 92% as reported against 1800 Clinical complex, RVC, Kanke, Ranchi with field cases of theileriosis caused by a history of fever, anorexia, weakness, Theileria annulata and T. parva, (McHardy, diarrhea and fall in milk yield. On clinical

5125

Int.J.Curr.Microbiol.App.Sci (2018) Special Issue-7: 5125-5126 examination, animal showed signs of fever, dipropionate and primaquine diphosphate general debility, respiratory distress, pale has been found effective in reducing T. conjuncitival membrane and enlarged orientalis parasitaemia in cattle. The prescapular lymph node. Hematological combined therapy of oxytetracycline, exam revealed Total RBC (1.20 primaquin phosphate and oxyclozanide million/cmm), Total WBC 6000/cmm), Hb resulted in recovery of the animal after two (5g%), PCV (17%), DLC (Neutrophil-74%, weeks. Lymphocyte-19%, Ecsinophil-1% and Monocyte 2%). The blood smear showed In conclusion, A case of mixed infection of blue coloured schizont in lymphocytes. theileriosis and amphistomasis and its Fecal exam revealed amphistome infection successful treatment with primaquin (+++). On the basis of history, clinical signs phosphate was reported and lab findings the condition was diagnosed as mixed infection of theileriosis References and amphistomiasis. Zhang, Z.H. (1980). The study of bovine Treatment and Discussion theileriosis. Yinchuon China Ningxia People’s Publishin House. The animal was treated with oxytetracycline Zhang, Z.H. (1987) Elimination of the LA 15mg/kg bwt IM, 3inj at 48 – 72 hrs gametocyte of Theileria annulata of interval along with Primaquine @ cattle by Primaquin phosphate. 0.75mg/kg/b.wt (Malarid DT) 10 tab OD for Veterinary Parasitology 23: 11 – 21 10 days. Amphistomiasis was treated with Stewart NP., de Vos AJ., and Shiels I. oxyclozanide @ 15 mg/kg b.wt for 3 days. (1990) Elimination of Theileria buffeli Supportive treatment was given in form on from cattle by concurrent treatment Inj Ferritas 10 ml IM alternate/day (5 with primaquin phosphate and injections) @ 0.5 mg/kg b. wt I.M and Inj halofugione lactate. Trop Anim Health Belamyl 10 ml I.M O.D for 3 days. Prod., 5: 22(2): 109 – 15. Hasanpour, A., Moghaddam G.A., and A. Primaquine phosphate is one of the several 8 namatollahi. (2008) Biochemical, – aminoquinoline antimalarial drug which hematological and electro- eliminates the erythrocytic stage of Theileria cardiagraphic changes in buffaloes annulata and has been used with success in naturally infected with Theileria control of thieleriosis in China (Zhang, annulata. Korean J. Parasitology 1980, 1987). Malarid DT (26.5 mg 46(4): 223-227. primaquine equivalent to 15 mg primaquin Mc Hardy, N., (1987) Experimental therapy base) Concurrent use of two treatments of of theileriosis. J. South Afr. Vet. Halofuginone Lactate and six of Primaquin Assoc., 50: 321 – 322. phosphate at the dose rate of 1 mg and 2 Razmi, GR., Hossint, M and Aslani., M.R. mg/kg b.wt respectively was fruitful in (2003) Identification of tick vectors of eliminating Theileria buffeli infection ovine theileriosis in an endemic region (Stewart et al., 1990). Imidocarb of Iran. Vet. Parasitol., 116: 1 – 6.

5126