PHKB Antibody Cat. No.: 23-353

PHKB Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids IMMUNOGEN: 854-1093 of human PHKB (NP_000284.1).

TESTED APPLICATIONS: WB

APPLICATIONS: WB: ,1:500 - 1:2000

POSITIVE CONTROL: 1) HepG2

2) SW620

3) Jurkat

4) BT-474

PREDICTED MOLECULAR Observed: 125kDa WEIGHT:

Properties

PURIFICATION: Affinity purification

CLONALITY: Polyclonal

September 25, 2021 1 https://www.prosci-inc.com/phkb-antibody-23-353.html ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: PHKB

phosphorylase b regulatory subunit beta, beta-subunit, ALTERNATE NAMES: phosphorylase kinase subunit beta, phosphorylase kinase, beta

GENE ID: 5257

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different . The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this , which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and BACKGROUND: can be encoded by three different genes. The gamma subunits contain the of the , whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on 14 and 20, respectively.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 25, 2021 2 https://www.prosci-inc.com/phkb-antibody-23-353.html