Misale et al., Supplementary Figure 5

A B 4 5 7 3 - 4 1 - H 2 3 - H 1 3 7 - H 1 7 9 2 - H 2 0 3 - H 2 1

P - 6 2 C a l u - 1 H C H O L U 9 A N C I N C I N C I N C I N C I S W Primary Target Drug Name ...... AKT GSK690693 MK-2206 ALK LDK378 / PF6463922 ALK5 (TGFBR1) SB52334 ALK, EGFR AP26113 ALK, MET AMPK pathway Phenformin Anti-metabolite Pemetrexed ATM KU-60019 ATR VE-822 Aurora A Alisertib, MLN8237 Aurora B AZD1152 Aurora, FLT3 VX680 Bax activator BAM7 BCL-2 ABT-263 Bcr-Abl, c-, PDGFR Bcr-Abl, SRC BET I-BET151 BRAF GW5074 PLX4032 BTK AVL-292 BTK, HER4 PCI-32765 CDK Dinaciclib Flavopiridol CDK1 RO-3306 CDK4/6 PD-0332991 CHK1 SCH900776 C CHK1,2 AZD7762 Drug ID Drug Name 640 CK2 CX-4945; Silmitasertib DAG Kinase R59022 113 BYL719 DNAPK KU57788 107 R406 EGFR EKB-569 282 EKB-569 596 AVL-292 EGFR, HER2 BIBW2992 5 51 Dasatinib EGFRm CO1686 77 TKI-258 Endothelin A R Zibotentan, ZD4054 81 BGJ398 EphB4 NVP-BHG712 125 BEZ235 ERK VX-11e 155 FAK PF-562271 326 GSK690693 TAE-226 370 AZD8055 Farnesyl Transferase Tipifarnib 424 MK-2206 FGFR BGJ398 491 SKI-606, FGFR, ABL, RTK Ponatinib 496 FGFR, VEGFR, PDG.. TKI-258 38 Saracatinib FLT3 AC220 119 Lapatinib FLT3, JAK2,TrkA, RET CEP-701/Lestaurtinib 127 GSK269962A g-secretase LY450139, Semagacestat 156 AZD6482 GSK3beta CHIR-99021 185 OSI-906 HDAC LBH589, Panobinostat 368 BIBW2992 SAHA, MK-0683 373 GDC0941 HDAC8 PCI-34051 385 ABT-263 Hsp70 Elesclomol 431 Alisertib, MLN8237 Hsp90 17-AAG 493 AG-013736 NVP-AUY922 32 VX680 STA-9090 75 RAF265 IAP LCL161 76 AEW541 TL32711-015 (Birinapant) 249 XL-184 IGF1R AEW541 546 FTY-720 OSI-906 566 SGI-1776 IKK2 BMS-345541 593 AP26113 JAK1,2, TYK2 INCB-18424 601 JNK-IN-8 JAK3 Tofacitinib, CP-690550 98 AZD1152 JNK JNK-IN-8 99 AZD6474/Zactima KIT 141 PCI-32765 PKC412 153 PKC412 MATE Pyrimethamine 154 CHIR-99021 MDM2 Nutlin 196 Phenformin MEK1/2 359 Gefitinib MET, VEGFR XL-184 417 AZD2281 mTOR 418 AZD7762 mTORC AZD8055 422 Elesclomol NAE MLN4924 425 PD-0332991 NAMPT FK-866, Daporinad 498 KU57788 p38, JNK2 BIRB 0796 523 GW843682X p70 S6KA PF-4708671 543 CX-4945; Silmitasertib PAK IPA-3 591 LDK378 PARP1/2 AZD2281 595 I-BET151 PI3K class 1 GDC0941 598 TAE-226 PI3K, MTORC BEZ235 602 Temsirolimus PI3Ka BYL719 60 BI-2536 PI3Kb AZD6482 105 MLN4924 PI3Kd IC-87114 128 PCI-34051 PI3Kg AS605240 194 NVP-AUY922 PIM CX-6258 203 BMS-345541 PIM1 SGI-1776 204 Tipifarnib PLK 1,2,3 BI-2536 246 Nutlin PLK1 GW843682X 254 AC220 Porcupine - Wnt LGK974 304 SB52334 Pro-Caspase PAC-1 430 Trametinib Proteasome Carfilzomib 537 SCH900776 RAF, KIT, VEGFR 597 CO1686 RAF, VEGFR2 RAF265/ CHIR-265 605 681640 ROCK GSK269962A 37 Crizotinib RSK, AURKB, PIM3 SL0101-1 175 PAC-1 RTK ABT-869 177 GSK650394 S1P FTY-720, Fingolimod 183 Dinaciclib SGK GSK650394 210 PLX4032 SMO GDC-0449 268 YM155 Sphingosine Kinase PF-543 292 Masitinib SRC Saracatinib 419 17-AAG SKI-606, Bosutinib 428 Pemetrexed Survivin YM155 438 LBH589, Panobinostat SYK R406 440 TL32711-015 (Birinap.. Tankyrase XAV939 495 GW 441756 TNFa Lenalidomide 522 RO-3306 TRKA GW 441756 538 KU-60019 VEGFR AG-013736 594 VE-822 Sunitinib, Sutent 603 CX-6258 VEGFR, EGFR, RET AZD6474/Zactima 21 R59022 WEE1, CHK1 681640 30 Sorafenib 71 Pyrimethamine 112 XAV939 158 PF-562271 224 AS605240 232 Carfilzomib 262 VX-11e 295 NVP-BHG712 432 Flavopiridol 518 BIRB 0796 528 PF-4708671 535 SAHA, MK-0683 545 FK-866, Daporinad 552 BAM7 592 Lorlatinib 600 Tofacitinib 0 2 4 6 8 10 Distinct count of Cell ID